AR009733A1 - NEW BISINDOLILMALEIMIDAS, SALTS OF THE SAME, PROCESSES FOR THEIR PREPARATION, USE OF SUCH COMPOUNDS TO PREPARE MEDICINES, PHARMACEUTICAL COMPOSITION AND INTERMEDIARY COMPOUNDS. - Google Patents

NEW BISINDOLILMALEIMIDAS, SALTS OF THE SAME, PROCESSES FOR THEIR PREPARATION, USE OF SUCH COMPOUNDS TO PREPARE MEDICINES, PHARMACEUTICAL COMPOSITION AND INTERMEDIARY COMPOUNDS.

Info

Publication number
AR009733A1
AR009733A1 ARP970104133A ARP970104133A AR009733A1 AR 009733 A1 AR009733 A1 AR 009733A1 AR P970104133 A ARP970104133 A AR P970104133A AR P970104133 A ARP970104133 A AR P970104133A AR 009733 A1 AR009733 A1 AR 009733A1
Authority
AR
Argentina
Prior art keywords
compounds
preparation
new
amino
hydrogen
Prior art date
Application number
ARP970104133A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR009733A1 publication Critical patent/AR009733A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se relaciona con nuevas bisindolilmaleimidas que comprenden la formula (I), en donde X es hidrogeno o metilo; R es un grupo de formula (II), en donde: nes 0 o 1; R2 es hidrogeno; R4 es hidrogeno, hidroxi, azida, amino, N-((C1-C5) alquil)amino, o N,N-di((C1-C5)alquil)amino; o R2 y R4 pueden formar juntos unenlace, cuando n es 1; R6 puede ser hidrogeno, hidroxi, azida, amino, o N,N-di ((C1-C5)alquil)amino; y R7 es hidrogeno, hidroximetilo, (C1-C5)alcoximetilo,azidometilo, aminometilo, N,N-di((C1-C5)alquil)aminometilo, y sales farmacéuticamente aceptables del mismo, proceso para su preparacion,intermediarios para los mismos, uso de dichos compuestos para preparar medicamentos, y composiciones farmacéuticas que los comprenden.It is related to new bisindolylmaleimides that comprise formula (I), where X is hydrogen or methyl; R is a group of formula (II), where: nes 0 or 1; R2 is hydrogen; R4 is hydrogen, hydroxy, azide, amino, N - ((C1-C5) alkyl) amino, or N, N-di ((C1-C5) alkyl) amino; or R2 and R4 can together form a bond, when n is 1; R6 can be hydrogen, hydroxy, azide, amino, or N, N-di ((C1-C5) alkyl) amino; and R7 is hydrogen, hydroxymethyl, (C1-C5) alkoxymethyl, azidomethyl, aminomethyl, N, N-di ((C1-C5) alkyl) aminomethyl, and pharmaceutically acceptable salts thereof, process for their preparation, intermediates therefor, use of said compounds to prepare medications, and pharmaceutical compositions comprising them.

ARP970104133A 1996-09-10 1997-09-10 NEW BISINDOLILMALEIMIDAS, SALTS OF THE SAME, PROCESSES FOR THEIR PREPARATION, USE OF SUCH COMPOUNDS TO PREPARE MEDICINES, PHARMACEUTICAL COMPOSITION AND INTERMEDIARY COMPOUNDS. AR009733A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603284A SE9603284D0 (en) 1996-09-10 1996-09-10 New compounds

Publications (1)

Publication Number Publication Date
AR009733A1 true AR009733A1 (en) 2000-05-03

Family

ID=20403829

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104133A AR009733A1 (en) 1996-09-10 1997-09-10 NEW BISINDOLILMALEIMIDAS, SALTS OF THE SAME, PROCESSES FOR THEIR PREPARATION, USE OF SUCH COMPOUNDS TO PREPARE MEDICINES, PHARMACEUTICAL COMPOSITION AND INTERMEDIARY COMPOUNDS.

Country Status (5)

Country Link
AR (1) AR009733A1 (en)
AU (1) AU4143297A (en)
SE (1) SE9603284D0 (en)
WO (1) WO1998011105A1 (en)
ZA (1) ZA977808B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005042002A2 (en) * 2003-10-30 2005-05-12 Entelos, Inc. Treatment of rhematoid arthritis with flip antagonists
JP2007532506A (en) * 2004-04-08 2007-11-15 ノバルティス アクチエンゲゼルシャフト Protein kinase C inhibitors for the treatment of autoimmune diseases and rejection
CN108264503A (en) * 2018-02-13 2018-07-10 东华大学 A kind of preparation method of 3- Indolylmaleimide compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (en) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituted pyrroles, their use for producing a drug, and the drug on their base
DE4005969A1 (en) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh NEW TRISUBSTITUTED PYRROLE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors

Also Published As

Publication number Publication date
SE9603284D0 (en) 1996-09-10
AU4143297A (en) 1998-04-02
ZA977808B (en) 1998-03-10
WO1998011105A1 (en) 1998-03-19

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