AR005969A1 - PROCEDURE FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING BENZOTHIOPHENES AS AN ACTIVE AGENT, IN DOSED UNITS OR MULTIPLE DOSE FORMULATIONS - Google Patents

PROCEDURE FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING BENZOTHIOPHENES AS AN ACTIVE AGENT, IN DOSED UNITS OR MULTIPLE DOSE FORMULATIONS

Info

Publication number
AR005969A1
AR005969A1 ARP970100726A ARP970100726A AR005969A1 AR 005969 A1 AR005969 A1 AR 005969A1 AR P970100726 A ARP970100726 A AR P970100726A AR P970100726 A ARP970100726 A AR P970100726A AR 005969 A1 AR005969 A1 AR 005969A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical compositions
compositions containing
multiple dose
procedure
preparing pharmaceutical
Prior art date
Application number
ARP970100726A
Other languages
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604912.7A external-priority patent/GB9604912D0/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR005969A1 publication Critical patent/AR005969A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un procedimiento para preparar composiciones farmacéuticas que contienen benzotiofenos de fórmula (I) como agente para inhibir la osteoporosis, regularla colesterolemia y/o inhibir el cáncer estrógeno-dependiente, como formulacionesde dosis múltiple o unidades dosificadas.A process for preparing pharmaceutical compositions containing benzothiophenes of formula (I) as an agent to inhibit osteoporosis, regulate cholesterolemia and / or inhibit estrogen-dependent cancer, as multiple dose formulations or dosage units.

ARP970100726A 1996-02-22 1997-02-21 PROCEDURE FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING BENZOTHIOPHENES AS AN ACTIVE AGENT, IN DOSED UNITS OR MULTIPLE DOSE FORMULATIONS AR005969A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1204496P 1996-02-22 1996-02-22
GBGB9604912.7A GB9604912D0 (en) 1996-03-08 1996-03-08 Benzothiophenes, formulations containing same, and methods

Publications (1)

Publication Number Publication Date
AR005969A1 true AR005969A1 (en) 1999-07-21

Family

ID=26308887

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP970100726A AR005969A1 (en) 1996-02-22 1997-02-21 PROCEDURE FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING BENZOTHIOPHENES AS AN ACTIVE AGENT, IN DOSED UNITS OR MULTIPLE DOSE FORMULATIONS
ARP970100727A AR005970A1 (en) 1996-02-22 1997-02-21 BENZOTIOFEN COMPOUNDS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM AS AN ACTIVE AGENT

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP970100727A AR005970A1 (en) 1996-02-22 1997-02-21 BENZOTIOFEN COMPOUNDS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM AS AN ACTIVE AGENT

Country Status (23)

Country Link
EP (1) EP0791591B1 (en)
JP (1) JP2000505455A (en)
KR (1) KR19990087091A (en)
CN (1) CN1211921A (en)
AR (2) AR005969A1 (en)
AT (1) ATE204869T1 (en)
AU (1) AU713204B2 (en)
BR (1) BR9707657A (en)
CA (1) CA2246721A1 (en)
CO (1) CO4761064A1 (en)
CZ (1) CZ260798A3 (en)
DE (1) DE69706338T2 (en)
DK (1) DK0791591T3 (en)
EA (1) EA000767B1 (en)
ES (1) ES2162196T3 (en)
IL (1) IL125863A (en)
NO (1) NO983802D0 (en)
NZ (1) NZ331461A (en)
PL (1) PL328832A1 (en)
PT (1) PT791591E (en)
TR (1) TR199801612T2 (en)
WO (1) WO1997030709A1 (en)
YU (1) YU6797A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2304138A1 (en) * 1997-09-23 1999-04-01 Eli Lilly And Company Benzothiophenes
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6060488A (en) * 1998-09-22 2000-05-09 Eli Lilly And Company Benzothiophenes for treating estrogen deficiency
AU2002224890B2 (en) * 2000-12-05 2007-03-22 F. Hoffmann-La Roche Ag Benzofuran and benzothiophene derivatives as selective COX-2 inhibitors
JP4656939B2 (en) * 2002-07-22 2011-03-23 イーライ リリー アンド カンパニー Selective estrogen receptor modulators containing phenylsulfonyl groups
EP1782810A3 (en) * 2002-07-22 2007-05-23 Eli Lilly & Company Selective estrogen receptor modulators containing a phenylsulfonyl group
ATE541840T1 (en) 2002-09-30 2012-02-15 Gea Farmaceutisk Fabrik As RALOXIFENE-L-LACTATE OR A HEMIHYDRATE THEREOF, USES THEREOF, PHARMACEUTICAL COMPOSITIONS AND PRODUCTION METHOD
KR100693242B1 (en) * 2003-02-25 2007-03-12 일라이 릴리 앤드 캄파니 Crystalline non-solvated 1-4-2-piperidinylethoxyphenoxy-2-4-methanesulfonylphenyl-6-hydroxynaphthalene hydrochloride
WO2005073190A1 (en) * 2004-01-29 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
GR1005694B (en) * 2005-06-08 2007-10-22 Αλεξης Μιχαηλ Tissue-specific antiestrogens specific for estrogen receptor
CN111018770A (en) * 2019-12-26 2020-04-17 北京鑫开元医药科技有限公司 Preparation method of bazedoxifene oxide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0062503A1 (en) * 1981-04-03 1982-10-13 Eli Lilly And Company Benzothiophene compounds and process for preparing them
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents

Also Published As

Publication number Publication date
IL125863A0 (en) 1999-04-11
EP0791591B1 (en) 2001-08-29
AU713204B2 (en) 1999-11-25
TR199801612T2 (en) 1998-11-23
DE69706338T2 (en) 2002-06-13
WO1997030709A1 (en) 1997-08-28
BR9707657A (en) 1999-07-27
NZ331461A (en) 1999-05-28
DE69706338D1 (en) 2001-10-04
EA000767B1 (en) 2000-04-24
AR005970A1 (en) 1999-07-21
IL125863A (en) 2000-10-31
NO983802L (en) 1998-08-19
YU6797A (en) 1999-09-27
CA2246721A1 (en) 1997-08-28
ES2162196T3 (en) 2001-12-16
JP2000505455A (en) 2000-05-09
CN1211921A (en) 1999-03-24
DK0791591T3 (en) 2001-10-08
NO983802D0 (en) 1998-08-19
AU2276497A (en) 1997-09-10
CZ260798A3 (en) 1999-05-12
PL328832A1 (en) 1999-02-15
ATE204869T1 (en) 2001-09-15
KR19990087091A (en) 1999-12-15
EA199800753A1 (en) 1999-02-25
CO4761064A1 (en) 1999-04-27
EP0791591A1 (en) 1997-08-27
PT791591E (en) 2001-12-28

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