AR005791A1 - MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN OR - Google Patents
MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN ORInfo
- Publication number
- AR005791A1 AR005791A1 ARP970100542A ARP970100542A AR005791A1 AR 005791 A1 AR005791 A1 AR 005791A1 AR P970100542 A ARP970100542 A AR P970100542A AR P970100542 A ARP970100542 A AR P970100542A AR 005791 A1 AR005791 A1 AR 005791A1
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- growth hormone
- antibody
- cells transformed
- expression plasmid
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Proteínas de hormonas del crecimiento humano mutantes que exhiben una mayor afinidad por el receptor de la hormona de crecimiento pero una menor actividadhormonal, secuencias de bases que codifican la misma. Las proteínas e acuerdo a la invención,co n sus mayores afinidades por el receptor de la hormona decrecimiento, pueden inhibir el enlace de la hormona de crecimiento a su receptor, manteniendo un bajo nivel de actividad hormonal, pudiendo así seraplicadas como medicamento para eltra tamiento de la acromegalia y el gigantismo. Se describen también un plásmido de expresión, un producto generadoa través de la expresión de células transformadas por dicho plásmido, un anticuerpo mutante y un medicamento para eltrata miento del gigantismo oacromegalia.Mutant human growth hormone proteins that exhibit higher affinity for the growth hormone receptor but lower hormonal activity, base sequences that encode it. The proteins according to the invention, with their greater affinities for the receptor of the decreasing hormone, can inhibit the binding of the growth hormone to its receptor, maintaining a low level of hormonal activity, thus being able to be applied as a treatment medication. of acromegaly and gigantism. An expression plasmid, a product generated through the expression of cells transformed by said plasmid, a mutant antibody and a drug for the treatment of gigantism or acromegaly are also described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5094096 | 1996-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005791A1 true AR005791A1 (en) | 1999-07-14 |
Family
ID=51929379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100542A AR005791A1 (en) | 1996-02-13 | 1997-02-12 | MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN OR |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR005791A1 (en) |
-
1997
- 1997-02-12 AR ARP970100542A patent/AR005791A1/en unknown
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