AR005791A1 - MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN OR - Google Patents

MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN OR

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Publication number
AR005791A1
AR005791A1 ARP970100542A ARP970100542A AR005791A1 AR 005791 A1 AR005791 A1 AR 005791A1 AR P970100542 A ARP970100542 A AR P970100542A AR P970100542 A ARP970100542 A AR P970100542A AR 005791 A1 AR005791 A1 AR 005791A1
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AR
Argentina
Prior art keywords
protein
growth hormone
antibody
cells transformed
expression plasmid
Prior art date
Application number
ARP970100542A
Other languages
Spanish (es)
Original Assignee
Japan Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Chem Res filed Critical Japan Chem Res
Publication of AR005791A1 publication Critical patent/AR005791A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Proteínas de hormonas del crecimiento humano mutantes que exhiben una mayor afinidad por el receptor de la hormona de crecimiento pero una menor actividadhormonal, secuencias de bases que codifican la misma. Las proteínas e acuerdo a la invención,co n sus mayores afinidades por el receptor de la hormona decrecimiento, pueden inhibir el enlace de la hormona de crecimiento a su receptor, manteniendo un bajo nivel de actividad hormonal, pudiendo así seraplicadas como medicamento para eltra tamiento de la acromegalia y el gigantismo. Se describen también un plásmido de expresión, un producto generadoa través de la expresión de células transformadas por dicho plásmido, un anticuerpo mutante y un medicamento para eltrata miento del gigantismo oacromegalia.Mutant human growth hormone proteins that exhibit higher affinity for the growth hormone receptor but lower hormonal activity, base sequences that encode it. The proteins according to the invention, with their greater affinities for the receptor of the decreasing hormone, can inhibit the binding of the growth hormone to its receptor, maintaining a low level of hormonal activity, thus being able to be applied as a treatment medication. of acromegaly and gigantism. An expression plasmid, a product generated through the expression of cells transformed by said plasmid, a mutant antibody and a drug for the treatment of gigantism or acromegaly are also described.

ARP970100542A 1996-02-13 1997-02-12 MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN OR AR005791A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5094096 1996-02-13

Publications (1)

Publication Number Publication Date
AR005791A1 true AR005791A1 (en) 1999-07-14

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100542A AR005791A1 (en) 1996-02-13 1997-02-12 MUTANT HUMAN GROWTH HORMONE PROTEIN; DESOXIRRIBO-NUCLEOTIDO THAT CODES IT; PEPTIDE OF SUCH PROTEIN; EXPRESSION PLASMID OF DESOXYRIBONUCLEOTIDE; PRODUCT GENERATED BY THE CELLS TRANSFORMED BY THE PREVIOUS; ANTIBODY AND MEDICINAL PRODUCT CONTAINING PROTEIN OR

Country Status (1)

Country Link
AR (1) AR005791A1 (en)

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