AR004507A1 - A TROVAFLOXACIN PROPHARMAC, A PROCEDURE TO TREAT A BACTERIAL INFECTION IN A MAMMAL THROUGH THE SAME, A PARAPREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND IT - Google Patents
A TROVAFLOXACIN PROPHARMAC, A PROCEDURE TO TREAT A BACTERIAL INFECTION IN A MAMMAL THROUGH THE SAME, A PARAPREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND ITInfo
- Publication number
- AR004507A1 AR004507A1 ARP960104085A AR10408596A AR004507A1 AR 004507 A1 AR004507 A1 AR 004507A1 AR P960104085 A ARP960104085 A AR P960104085A AR 10408596 A AR10408596 A AR 10408596A AR 004507 A1 AR004507 A1 AR 004507A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- mammal
- trovafloxacin
- pharmaceutical composition
- bacterial infection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a un profármaco de trovafloxacina que tiene la fórmula (I) que se selecciona entre su polimorfo PII y el monohidratoPIIM y el pseudomorfo PIIPS del mismo y un procedimiento para su preparación. Se describen elp olimorofo PII y el monohidrato PII.M y pseudomorfo PIIPS delmismo. La invención se refiere además a un procecimiento para tratar una infección bacteriana en un mamífero que comprende administrar a dicho mamíferouna cantidad eficaz de dichopro fármaco, y a una composición farmacéutica para el tratamiento de infecciones bacterianas en mamíferos que comprende unacantidad eficaz de dicho profármaco en un vehículo farmacéuticamente aceptable.The present invention relates to a trovafloxacin prodrug having the formula (I) which is selected from its polymorph PII and the monohydrate PIIM and the pseudomorph PIIPS thereof and a process for its preparation. The p olimorofo PII and the monohydrate PII.M and pseudomorph PIIPS thereof are described. The invention further relates to a process for treating a bacterial infection in a mammal that comprises administering to said mammal an effective amount of said prodrug, and to a pharmaceutical composition for the treatment of bacterial infections in mammals that comprises an effective amount of said prodrug in a vehicle. pharmaceutically acceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US510995P | 1995-08-29 | 1995-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004507A1 true AR004507A1 (en) | 1998-12-16 |
Family
ID=21714229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104085A AR004507A1 (en) | 1995-08-29 | 1996-08-23 | A TROVAFLOXACIN PROPHARMAC, A PROCEDURE TO TREAT A BACTERIAL INFECTION IN A MAMMAL THROUGH THE SAME, A PARAPREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND IT |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6080756A (en) |
| EP (1) | EP0847400B1 (en) |
| JP (1) | JPH11509188A (en) |
| KR (1) | KR100274736B1 (en) |
| CN (1) | CN1193977A (en) |
| AP (1) | AP639A (en) |
| AR (1) | AR004507A1 (en) |
| AT (1) | ATE208790T1 (en) |
| AU (1) | AU696414B2 (en) |
| BR (1) | BR9610283A (en) |
| CA (1) | CA2230303C (en) |
| CO (1) | CO4480740A1 (en) |
| CZ (1) | CZ291524B6 (en) |
| DE (1) | DE69617027T2 (en) |
| DK (1) | DK0847400T3 (en) |
| DZ (1) | DZ2088A1 (en) |
| ES (1) | ES2164892T3 (en) |
| GT (1) | GT199600061A (en) |
| HR (1) | HRP960396A2 (en) |
| HU (1) | HUP9900226A3 (en) |
| IL (1) | IL122652A (en) |
| MA (1) | MA23965A1 (en) |
| NO (1) | NO309039B1 (en) |
| NZ (1) | NZ310542A (en) |
| OA (1) | OA10670A (en) |
| PL (1) | PL185709B1 (en) |
| PT (1) | PT847400E (en) |
| RU (1) | RU2151152C1 (en) |
| SK (1) | SK283354B6 (en) |
| TN (1) | TNSN96110A1 (en) |
| TR (1) | TR199800340T1 (en) |
| UA (1) | UA48982C2 (en) |
| WO (1) | WO1997008191A1 (en) |
| YU (1) | YU48296A (en) |
| ZA (1) | ZA967281B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN1998000106A (en) * | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | PARENTERAL COMPOSITIONS OF ALATROFLAXACINO |
| US6239141B1 (en) * | 1999-06-04 | 2001-05-29 | Pfizer Inc. | Trovafloxacin oral suspensions |
| CN105510497A (en) * | 2015-11-30 | 2016-04-20 | 精晶药业股份有限公司 | Quantitative detection method of L-alanyl-L-alanine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
-
1996
- 1996-07-05 IL IL12265296A patent/IL122652A/en not_active IP Right Cessation
- 1996-07-05 TR TR1998/00340T patent/TR199800340T1/en unknown
- 1996-07-05 SK SK237-98A patent/SK283354B6/en unknown
- 1996-07-05 AT AT96918806T patent/ATE208790T1/en not_active IP Right Cessation
- 1996-07-05 CA CA002230303A patent/CA2230303C/en not_active Expired - Fee Related
- 1996-07-05 CN CN96196577A patent/CN1193977A/en active Pending
- 1996-07-05 CZ CZ1998552A patent/CZ291524B6/en not_active IP Right Cessation
- 1996-07-05 PT PT96918806T patent/PT847400E/en unknown
- 1996-07-05 RU RU98103462/04A patent/RU2151152C1/en not_active IP Right Cessation
- 1996-07-05 US US09/011,370 patent/US6080756A/en not_active Expired - Fee Related
- 1996-07-05 UA UA98021016A patent/UA48982C2/en unknown
- 1996-07-05 NZ NZ310542A patent/NZ310542A/en unknown
- 1996-07-05 AU AU61351/96A patent/AU696414B2/en not_active Ceased
- 1996-07-05 DE DE69617027T patent/DE69617027T2/en not_active Expired - Fee Related
- 1996-07-05 DK DK96918806T patent/DK0847400T3/en active
- 1996-07-05 PL PL96325203A patent/PL185709B1/en unknown
- 1996-07-05 KR KR1019980701467A patent/KR100274736B1/en not_active IP Right Cessation
- 1996-07-05 WO PCT/IB1996/000653 patent/WO1997008191A1/en active IP Right Grant
- 1996-07-05 HU HU9900226A patent/HUP9900226A3/en unknown
- 1996-07-05 ES ES96918806T patent/ES2164892T3/en not_active Expired - Lifetime
- 1996-07-05 JP JP9504021A patent/JPH11509188A/en active Pending
- 1996-07-05 BR BR9610283A patent/BR9610283A/en not_active Application Discontinuation
- 1996-07-05 EP EP96918806A patent/EP0847400B1/en not_active Expired - Lifetime
- 1996-08-09 GT GT199600061A patent/GT199600061A/en unknown
- 1996-08-23 AR ARP960104085A patent/AR004507A1/en unknown
- 1996-08-28 DZ DZ960132A patent/DZ2088A1/en active
- 1996-08-28 ZA ZA9607281A patent/ZA967281B/en unknown
- 1996-08-28 MA MA24343A patent/MA23965A1/en unknown
- 1996-08-28 TN TNTNSN96110A patent/TNSN96110A1/en unknown
- 1996-08-28 YU YU48296A patent/YU48296A/en unknown
- 1996-08-29 CO CO96046150A patent/CO4480740A1/en unknown
- 1996-08-29 HR HR60/005,109A patent/HRP960396A2/en not_active Application Discontinuation
- 1996-08-29 AP APAP/P/1996/000854A patent/AP639A/en active
-
1998
- 1998-02-27 NO NO980863A patent/NO309039B1/en unknown
- 1998-02-27 OA OA9800027A patent/OA10670A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA04012965A (en) | Viral inhibitors. | |
| EA199901014A1 (en) | C-4 "-SUBLISHED MACROLIDE DERIVATIVES | |
| BG101118A (en) | Therapeutical compounds | |
| UY26635A1 (en) | SYNERGIC METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | |
| AR035927A1 (en) | LACTAMA COMPOUND (N) - ((S) -2-HIDROXI-3-METHYLBUTIRILE) -1- (L-ALANINIL) - (S) -1-AMINO-3-METHYL-4,5,6,7-TETRAHYDRO -2H-3-BENZAZEPIN-2-ONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE FOR THE INHIBITION OF THE B-AMYLOID PEPTIDE RELEASE AND / OR ITS SYNTHESIS THAT USES IT AND ITS USE FOR THE FABR | |
| RU95106362A (en) | Lipopeptide derivatives, process for preparation thereof, pharmaceutical composition containing said derivatives, and process for preparation of said composition | |
| GT199900208A (en) | CARBAMATO AND CARBAZATO CETÒLID ANTIBIOTICS. | |
| MY119375A (en) | Treatment of tinnitus using neuroprotective agents | |
| EA200400701A1 (en) | 13-MEMBER AZALIDES AND THEIR APPLICATION AS ANTIBIOTIC AGENTS | |
| LU88684I2 (en) | Amphotericin b lipid complex and their pharmaceutically acceptable derivatives (abelcet) | |
| ES2174921T3 (en) | HIV PROTEASE INHIBITORS. | |
| BR0002577A (en) | Oral suspensions of trovafloxacin | |
| ATE457177T1 (en) | COMBINATION THERAPY FOR THE TREATMENT OF RESPIRATORY DISEASES USING ANTIBODIES AND ANTI-INFLAMMATORY ACTIVES | |
| RU94036745A (en) | Galantamine derivatives and pharmaceutical composition | |
| EA200200995A1 (en) | APPLICATION OF AZALIDE ANTIBIOTIC COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF BACTERIAL OR PROTOSOIC INFECTIONS IN MAMMALS | |
| BR9712141A (en) | Application of 1-hyphroxy-2-pyridones to treat skin infections. | |
| AR004507A1 (en) | A TROVAFLOXACIN PROPHARMAC, A PROCEDURE TO TREAT A BACTERIAL INFECTION IN A MAMMAL THROUGH THE SAME, A PARAPREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND IT | |
| MX9805441A (en) | Therapeutic compounds. | |
| KR970704436A (en) | TERPENOIDIC DERIVATIVES (SARCODICTYINS) USEFUL AS ANTITUMOR AGENTS USEFUL AS ANTI-TUMORS | |
| EA200001029A1 (en) | HYGROMYCIN DERIVATIVES | |
| HUP0203050A2 (en) | Treating endometriosis or infertility, or improving fertility | |
| AR002191A1 (en) | ORAL PHARMACEUTICAL COMPOSITION OF PIPERIDINOALCANOL COMPOUNDS IN THE FORM OF SOLUTION, PROCEDURE FOR ITS PREPARATION | |
| MX9705916A (en) | Combination therapy for hiv infection using the hiv protease inhibitor indinavir adn the reverse transcriptase inhibitor 3tc, optionally together with azt, ddi or ddc. | |
| Glavin et al. | Evidence of “cross-stressor”-induced adaptive gastric cytoprotection | |
| DE69124380D1 (en) | METHOD AND COMPOSITIONS FOR THE TREATMENT BY T-CELL-MEDIATED DISEASES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |