AR003970A1 - NEW ANTAGONIST COMPOUNDS FOR ENDOTHELINE RECEPTORS, PROCEDURE FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, AND PROCEDURE FOR PREPARING THESE PHARMACEUTICAL COMPOSITIONS. - Google Patents
NEW ANTAGONIST COMPOUNDS FOR ENDOTHELINE RECEPTORS, PROCEDURE FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, AND PROCEDURE FOR PREPARING THESE PHARMACEUTICAL COMPOSITIONS.Info
- Publication number
- AR003970A1 AR003970A1 ARP960103764A AR10376496A AR003970A1 AR 003970 A1 AR003970 A1 AR 003970A1 AR P960103764 A ARP960103764 A AR P960103764A AR 10376496 A AR10376496 A AR 10376496A AR 003970 A1 AR003970 A1 AR 003970A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparing
- procedure
- pharmaceutical compositions
- unsubstituted
- antagonist compounds
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento se refiere a nuevos compuestos antagonistas de receptores de endotelina de fórmula (I), en la que: -Y-Z- representa -NR7-CO, -NaC(OR7)- ó-N=CR8-; R1 representa Ar; R2 representa COOR6, CN, 1H-tetrazol-5-ilo ó CONHSO2Ar; R3, R4,R5, independientemente, representan R6, OR6, S(O)mR6, Hal,NO2, NR6R6, NHCOR6, NHSO2R6, OCOR6, COOR6 ó CN; R6 y R6 independientemente representan H, alquilo de 1 a 6 átomos de carbono, bencilo o fenilo; R1representa (CH2)nAr; R representa Ar ó OA; Ar es un fenilo no sustituido o sustituido una, dos o tres veces con R9, R10 ó R11 o un naftilo no sustituido oun grupo (II) no sustituido o sustituido una o dos veces en el fenilo con R7 ó R10 o un grupo (III) no sustituido o sustituido una odos veces en el ciclohexadienilo con R4 o R10; R9, R10, R11 independientemente, representan R6, OR6, Hal, CF3, OCF1, OCHF2, OCH2F, NO2, NR6R6, NHCOR6, CN, NHSO2R6, COOR6, COR6,CONHSO2Ar, O(CH2)nR2, O(CH2)nOR6 ó S(O)mR6; E representa CH2, S ú O; prepresenta carbonilo ó [C(R6R6)]n; Hal representa F, Cl, Br ó I; X representaO ó S; m es 0, 1 ó 2; n es 1 ó 2.The invention relates to new endothelin receptor antagonist compounds of formula (I), in which: -Y-Z- represents -NR7-CO, -NaC (OR7) - or-N = CR8-; R1 represents Ar; R2 represents COOR6, CN, 1H-tetrazol-5-yl or CONHSO2Ar; R3, R4, R5, independently, represent R6, OR6, S (O) mR6, Hal, NO2, NR6R6, NHCOR6, NHSO2R6, OCOR6, COOR6 or CN; R6 and R6 independently represent H, alkyl of 1 to 6 carbon atoms, benzyl or phenyl; R1 represents (CH2) nAr; R represents Ar or OA; Ar is a phenyl unsubstituted or substituted one, two or three times with R9, R10 or R11 or an unsubstituted naphthyl or a group (II) unsubstituted or substituted one or two times in the phenyl with R7 or R10 or a group (III ) unsubstituted or substituted one or two times in the cyclohexadienyl with R4 or R10; R9, R10, R11 independently represent R6, OR6, Hal, CF3, OCF1, OCHF2, OCH2F, NO2, NR6R6, NHCOR6, CN, NHSO2R6, COOR6, COR6, CONHSO2Ar, O (CH2) nR2, O (CH2) nOR6 or S (O) mR6; E represents CH2, S or O; carbonyl or [C (R6R6)] n; Hal represents F, Cl, Br or I; X represents O or S; m is 0, 1 or 2; n is 1 or 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19527668 | 1995-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003970A1 true AR003970A1 (en) | 1998-09-30 |
Family
ID=51983095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103764A AR003970A1 (en) | 1995-07-28 | 1996-07-26 | NEW ANTAGONIST COMPOUNDS FOR ENDOTHELINE RECEPTORS, PROCEDURE FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, AND PROCEDURE FOR PREPARING THESE PHARMACEUTICAL COMPOSITIONS. |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR003970A1 (en) |
-
1996
- 1996-07-26 AR ARP960103764A patent/AR003970A1/en unknown
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