AR001661A1 - A procedure to prepare racemic 1- (r, s) - (2-pyridyl) -2-cyclohexylethylamine a procedure to separate (+) - s-sigma (-) - r-1- (2-pyridyl) -2-cyclohexylethylamine from the racemic mixture procedure to prepare a leukotriene biosynthesis inhibitor using these separate enantiomers and a procedure to prepare (+) - or (-) - 3-bromocampho-8-sulfonic acid used in the separation of the enantiomers - Google Patents

A procedure to prepare racemic 1- (r, s) - (2-pyridyl) -2-cyclohexylethylamine a procedure to separate (+) - s-sigma (-) - r-1- (2-pyridyl) -2-cyclohexylethylamine from the racemic mixture procedure to prepare a leukotriene biosynthesis inhibitor using these separate enantiomers and a procedure to prepare (+) - or (-) - 3-bromocampho-8-sulfonic acid used in the separation of the enantiomers

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Publication number
AR001661A1
AR001661A1 AR33621796A AR33621796A AR001661A1 AR 001661 A1 AR001661 A1 AR 001661A1 AR 33621796 A AR33621796 A AR 33621796A AR 33621796 A AR33621796 A AR 33621796A AR 001661 A1 AR001661 A1 AR 001661A1
Authority
AR
Argentina
Prior art keywords
procedure
prepare
cyclohexylethylamine
pyridyl
enantiomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AR33621796A
Other languages
Spanish (es)
Inventor
Karl Georg Grozinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Priority to AR33621796A priority Critical patent/AR001661A1/en
Publication of AR001661A1 publication Critical patent/AR001661A1/en
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Abstract

Esta invención se refiere a la preparación de 1-(piridil)-2-ciclohexiletilamina racémica y enantiómera y, en particular, a laseparación (+) - (S)- ó (-)-(R)-1-(2-piridil)-2-ciclohexiletilamina a partir de una mezcla racémica de 1-(R,S)-(2-piridil)-2-ciclohexiletilamina. De acuerdocon esta invención, la separación de una mezcla racémica de 1-(piridil)-2- ciclohexiletilamina se lleva a cabo utilizando ácido 3-bromocanfo-8-sulfónico(BCSA). Esta invención se refiere también a un procedimiento para preparar una mezcla racémica de 1-(piridil)-2-ciclohexiletilamina y BCSA libre a partir demateriales de partida fácilmente disponibles.This invention relates to the preparation of racemic and enantiomeric 1- (pyridyl) -2-cyclohexylethylamine and, in particular, to the separation (+) - (S) - or (-) - (R) -1- (2-pyridyl ) -2-cyclohexylethylamine from a racemic mixture of 1- (R, S) - (2-pyridyl) -2-cyclohexylethylamine. According to this invention, the separation of a racemic mixture of 1- (pyridyl) -2-cyclohexylethylamine is carried out using 3-bromocampho-8-sulfonic acid (BCSA). This invention also relates to a process for preparing a racemic mixture of 1- (pyridyl) -2-cyclohexylethylamine and free BCSA from readily available starting materials.

AR33621796A 1996-04-19 1996-04-19 A procedure to prepare racemic 1- (r, s) - (2-pyridyl) -2-cyclohexylethylamine a procedure to separate (+) - s-sigma (-) - r-1- (2-pyridyl) -2-cyclohexylethylamine from the racemic mixture procedure to prepare a leukotriene biosynthesis inhibitor using these separate enantiomers and a procedure to prepare (+) - or (-) - 3-bromocampho-8-sulfonic acid used in the separation of the enantiomers Pending AR001661A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AR33621796A AR001661A1 (en) 1996-04-19 1996-04-19 A procedure to prepare racemic 1- (r, s) - (2-pyridyl) -2-cyclohexylethylamine a procedure to separate (+) - s-sigma (-) - r-1- (2-pyridyl) -2-cyclohexylethylamine from the racemic mixture procedure to prepare a leukotriene biosynthesis inhibitor using these separate enantiomers and a procedure to prepare (+) - or (-) - 3-bromocampho-8-sulfonic acid used in the separation of the enantiomers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR33621796A AR001661A1 (en) 1996-04-19 1996-04-19 A procedure to prepare racemic 1- (r, s) - (2-pyridyl) -2-cyclohexylethylamine a procedure to separate (+) - s-sigma (-) - r-1- (2-pyridyl) -2-cyclohexylethylamine from the racemic mixture procedure to prepare a leukotriene biosynthesis inhibitor using these separate enantiomers and a procedure to prepare (+) - or (-) - 3-bromocampho-8-sulfonic acid used in the separation of the enantiomers

Publications (1)

Publication Number Publication Date
AR001661A1 true AR001661A1 (en) 1997-11-26

Family

ID=37027983

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33621796A Pending AR001661A1 (en) 1996-04-19 1996-04-19 A procedure to prepare racemic 1- (r, s) - (2-pyridyl) -2-cyclohexylethylamine a procedure to separate (+) - s-sigma (-) - r-1- (2-pyridyl) -2-cyclohexylethylamine from the racemic mixture procedure to prepare a leukotriene biosynthesis inhibitor using these separate enantiomers and a procedure to prepare (+) - or (-) - 3-bromocampho-8-sulfonic acid used in the separation of the enantiomers

Country Status (1)

Country Link
AR (1) AR001661A1 (en)

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