AP54A - Insecticidal cyclopropyl-substituted di (aryl) compounds. - Google Patents

Abstract

Compounds of the formula in which ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; z is oxygen, sulphur, or menthylene and ar' is 2-methyl [1,1'-biphenyl]-3-y1, 3-phenoxy phenyl, 4-fluoro-3-phenoxyphenyl, or 6-phenoxy-2-pyridyl exhibit pyrethroid-like insecticidal and acaricidal activity and are relatively harmless to aquatic fauna.

Description

INSECTICIDAL CYCLOPROPYL-SUBSTITUTED DI(ARYL) COMPOUNDS

This invention relates to novel pyrethroid-like insecticides which effectively control infestations of 5 undesirable insects and acarids and simultaneously display remarkably low toxicity to fish. Synthetic pyrethroids have been the focus of intensive research activity for more than a decade. The pioneering work of Elliott, as described in U.S. 4,024,163, established 10 that synthetic pyrethroids could be synthesized with sufficient stability to light to be commercially attractive. The vast majority of these new pyrethroids are esters of substituted cyclopropanecarboxylic acids similar to those described by Elliott. Initially, cora15 pounds having the aforementioned structure were thought to‘be required for insecticidal activity; however, considerable effort has been successfully directed toward defining compounds which are nominally described as pyrethroids based upon similarities in molecular geom2q etry and insecticidal activity. In some of these compounds only the ester linkage has been retained; in others the substituted cyclopropane ring has been retained; and in yet others neither the substituted cyclopropane ring nor the ester linkage has been 25 retained. Τυ the current invention an unsubs'·, jtuted cyclopropi ne group is incorporated into pyrethre. Zu-'J j > e compounds. These novel compounds lack the subst ituted cyclopropanecarboxylic acid moiety typical of the compounds described by Elliott and those who followed him.

₃θ Further, <bene compounds display pyrethroid-like insecticidal activity while possessing remarkably jow toxicity to fish in comparison with the notorious »

toxicity to fish exhibited by cyclopropanecarboxyiates.

United States Patent 4,397,864 discloses a class of ₃₅ pyrethroid-like compounds having the following subgeneric formula:

BAD ORIGINAL $

-2CH

I

Ar-C-

wherein

Ar is optionally substituted phenyl, * optionally substituted naphthyl, or 1,3-benzodioxol-5-yl;

R is lower alkyl;

Y is O or S;

Z is 0, S, or a carbonyl or methylene group;

R' is H, F, lower alkyl, or lower alkoxy; and n is 1-5.

These compounds are alleged to have high insecticidal activity and low toxicity to fish.

United States Patent*4,073,812 covers a closely related series of compounds having the generic formula;

r.

(R) wherein

R is halogen, lower alkyl, or lower alkoxy; m is 1 or 2;

. R¹ is branched chain alkyl of 3-6 carbon atoms;

R² is hydrogen or alkynyl of 2-4 carbon atoms; R³ is fluorine; and · n is 0 or 1.

-3In all examples R¹ is isopropyl. All compounds are asserted to be insecticidal, some more than others, but there is no indication or assertion about the degree of toxicity to fish.

United States Patent 4,562,213 covers another similar series of compounds of the formula:

wherein

R¹ is hydrogen, halogen, or methyl?

R² is hydrogen or fluorine? ’

W is CH or N? ¹

A is oxygen, methylehe, or imino? I

X and Y are both methyl or taken together form an optionally substituted cyclopropane ¹ ring?

R³ and R⁴ may be the same or different and are hydrogen, halogen, lower alkyl, lower alkoxy, lower fluoroalkoxy, or taken together form a methylenedioxy bridge.

In all cases where A is oxygen, X and Y are taken together to form a cyclopropane ring or a substituted cyclopropane ring. These compounds are asserted to be insecticidal and acaricidal without any assertion

3Q relating to fish toxicity.

. United Kingdom patent application GB 2 120 664A , discloses a class of aromatic-substituted alkane derivaf ' tives having the following generic formula: ¹

AP 0 0 0 0 5 4

I

-4R¹

Ar-C-CH₂CH₂R³

R² wherein

Ar stands for a substituted or unsubstituted phenyl or naphthyl group;

rL stands for a methyl, ethyl, or isopropyl group and

R² stands for a hydrogen atom or a methyl group or R¹ and R² taken together with the carbon to which they are attached represent a substituted or unsubstituted cycloalkyl group; and

R³ stands for the residue of an alcohol, R³OH, commonly found in natural or synthetic pyrethroids.

Examples of substituted or unsubstituted cycloalkyl groups named or exemplified by taking R¹ and R² together with the carbon to which they are attached are cyclopropyl, 2,2-dichlorocyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. These compounds are Asserted to be highly insecticidal and acaricidal and to have low toxicity to mammals and fish.

Belgian patent 902147 discloses a class of compounds having the following generic formula:

R¹

Ar-C-CR³=CR⁴CHDR_B

I

R²

I

-510 wherein

Ar represents a substituted or unsubstituted phenyl or naphthyl group;

R¹ and R² taken together with the carbon atom to which they are attached represent a substituted or unsubstituted cycloalkyl group of 3-6 carbon atoms? .:

R³ and R⁴, which may be the same or different, are hydrogen, halogen, or C^-Cg alkyl;

Rg represents the residue of an alcohol, RgCHDOH, which provides significant insecticidal activity when esterified with IE,cis-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylic acid; and

D is hydrogen or cyano.

The compounds of this invention may be described as 2-(optionally substituted aryl)-2-cyclopropylethyl substituted-benzyl ethers and thioethers and 1-(optionally substituted aryl)-l-cyclopropyl-4-(substituted aryl)butanes. These compounds contain an asymmetric carbon atom; the invention thus includes individual'stereoisomers as well as racemic and non-racemic mixtures of enantiomers of the instant compounds.

This invention also encompasses insecticidal compositions containing the pyrethroid ethers, thioethers, and butanes and their use for controlling insects. The compounds of this invention are effective for control of a wide variety of insects and acarids and may be expected to be useful in any situation for which pyrethroid insecticides are indicated. The compounds of this invention find particular utility in applications where there is a possibility of significant contamination of streams, rivers, and lakes by insecticidal material.- Their low toxicity to fish will obviate concern about potential ecological problems associated

AP 0 0 0 0 5 4 t· * J

-6with the use of pyrethroids in environments where such contamination is possible.

The 2-(optionally substituted aryl)-2-cyclopropylethyl substituted-benzyl ethers, thioethers, and the 1(optionally substituted aryl)-l-cyclopropyl-4-(substituted aryl)butanes have the general formula:

Ar-CH-CH₂-Z-CH₂-Ar * in which Ar is a substituted or unsubstituted phenyl, naphthyl, or thienyl. A substituted Ar may have one or two, not necessarily identical, substituents. Preferably Ar is phenyl and is monosubstituted at the

4-position. Preferred substituents include, but are not limited to, (Cj-g)alkyl, halo, (0^.4)haloalkyl, (C1-4)alkoxy, (C1..4) haloalkoxy. Halo included fluoro, chloro, and bromo. The term alkyl includes straight and branched chain alkyl groups having 1-6 carbon atoms, preferably 1-4 carbon atoms. The terms haloalkyl and haloalkoxy include alkyl and alkoxy groups in which one or more hydrogen atoms have been replaced by fluorine, chlorine, or bromine atoms including all combinations thereof. Further, the substituent may have the structure -A-(CRiR^)_n-A- where Rl and r2 are independently, hydrogen, halogen, or (Ci_₂)alkyl/ n is 1 or 2, and each A, which may be 0, S, or CH₂, is bonded to a carbon atom of the aromatic ring, the carbons to which the A groups are, attached being adjacent to each other in the ring. Illustrative of this mode of substitution are compounds in which Ar is 1,3-benzodioxolyl, 2,2-difluoro-1,3benzodioxolyl, or 2,3-dihydro-2,2-dimethylb4nzofuranyl.

-7Typical Ar groups include:

phenyl, fluorophenyl, chlorophenyl, bromophenyl, preferably, 4-chlorophenyl;

methylphenyl, ethylphenyl, propylphenyl, isopropyl5 phenyl, butylphenyl, isobutylphenyl, sec-butylphenyl, tert-butylphenyl, preferably methylphenyl;

methoxyphenyl, ethoxyphenyl, propoxyphenyl, isopropoxyphenyl, butoxyphenyl, isobutoxyphenyl, sec-butoxyphenyl, or tert-butoxyphenyl, preferably methoxyphenyl or ethoxyphenyl;

fluoromethylphenyl, chloromethylphenyl, trifluoromethylphenyl , difluoromethylphenyl, fluoroethylphenyl, chloroethylphenyl, preferably trifluoromethylphenyl;

difluoromethoxyphenyl, trifluoromethoxyphenyl,

2-fluoroethoxyphenyl, 1,1,2,2-tetrafluoroethoxyphenyl,

2-bromo-l-l,2,2-tetrafluoroethoxyphenyl, preferably tri fluoromethoxyphenyl or difluoromethoxyphenyl;

1,3-benzodioxol-5-yl, 2,2-difluoro-1,3-benzodioxol5-yl, naphthyl, thienyl, 2,3-dihydro-2,2-dimethylbenzo2q furan-5-yl, 2,2,3,3-tetrafluorobenzofuran-5-yi, and 2,3-dihydro-2,2-dimethylbenzofuran-7-yl;

Z is oxygen, sulfur, or methylene;

Ar* is 2-methyl[1,1’-biphenyl]-3-yl, 3-phenoxyphenyl, 4-fluoro-3-phenoxyphenyl, and 6-phenoxy-2₂₅ pyridyl, preferably 4-fluoro-3-phenoxyphenyl. Substitution of the phenyl, pyridyl, or phenoxy moieties with l

halogen or lower alkyl is within the scope of this invention.

The ether and thioether compounds of this invention jq are prepared by reacting an appropriate 2,2-disubstituted ethanol or thioethanol with sodium hydride, thus preparing the corresponding sodium ethoxide. The ethoxide or thioethoxide can, in turn, be reacted with an appropriately substituted benzyl halide to prepare the insecticidal ether*or thioether. Example 1

-8describes the reaction of 2-cyclopropyl-2-(4-chlorophenyl)ethanol with sodium hydride in tetrahydrofuran and the reaction of the resulting sodium salt with (4fluoro-3-phenoxyphenyl)methyl chloride to prepare (4fluoro-3-phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl ether, Compound 16 of Table 1.

Numerous references describe the preparation of the substituted halides or preparation of the corresponding alcohols from which the halides may be prepared by conventional methods. The halides may be selected from chlorides, bromides, or iodides. Other leaving groups that may be readily displaced by a substituted ethoxide or thioethoxide may be substituted for the halogen atom of the benzyl halide. Examples of such leaving groups include, but are not limited to, methanesulfonate, trifluoromethanesulfonate, and p-toluenesulfonate.

The alcohol intermediates may be prepared from the aryl cyclopropyl ketones by conventional methods. In Example 1 the 4-chlorophenyl cyclopropyl ketone is reacted with sodium hydride and methyl triphehylphosphonium bromide to prepare 1-(4-chlorophenyl)-1cyclopropylethene. Hydroboration of this olefin with bis(3-methyl-2-butyl)borane, followed by treatment with aqueous sodium hydroxide and hydrogen peroxide completes the synthesis of the ethanol from which the ether may be prepared as described above.

The substituted ethanol may be converted to the corresponding ethanethiol by reacting triphenylphosphine with diisopropyl azodicarboxylate and then reacting the resulting intermediate with the substituted ethanol. Quenching this reaction with thiolacetic acif produces the thiolacetate. Reduction of the thiolacetate produces the substituted thiol from which the thioether can be prepared by the same method described above for the ethers. Example 2 details the synthesis of {4-fluoro-3J

-910 phenoxy)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl thioether, Compound 21 of Table 1 by this method.

Separation of the optical isomers can be effected by first preparing the 2,2-disubstituted acetic acid. One method for this preparation is to react the aryl cyclopropyl ketone with the anion prepared from 2-trimethylsilyl-1,3-dithiane and p-butyllithium. The Resulting 2[ (aryl)cyclopropylmethylene]-1,3-dithiane may then be reacted with mercury (II) chloride, water, and methanol, producing methyl 2-aryl-2-cyclopropylacetate. Hydrolysis of the acetate to the acid and preparation of the acid chloride may be followed by reaction with (S)-4-(1methylethyl)-2-oxazolidinone, previously prepared by reacting (S)-2-amino-3-methyl-l-butanol with phosgene. The two diastereomers of N-(2-aryl-2-cyclopropylacetyl)4- (1-methylethyl) -2-oxazolidinone may then be separated chromatographically. Reduction of the individual diastereomers of the oxazolidinone with lithium aluminum hydride produces the (S) or (R)-2-aryl-2-cyclopropylethanols, each substantially free of the oth^r antipode. In Example 3 details are provided for this method of preparing the two stereoisomers of (4-f luoroi-3-phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl ether, Compounds 17 and 18 of Table 1.

The saturated, hydrocarbon compounds of this invention are prepared by reacting a substituted-phenyl cyclopropyl ketone with vinylmagnesium bromide to prepare the corresponding 1-(substituted phenyl)-1-cyclopropyl-2-propen-l-ol. Oxidation of this unsaturated alcohol yields 3-(substituted phenyl)-3-cyclopropylpropenal. The reaction of triphenylphosphine and a substituted-benzyl bromide yields the corresponding substituted benzyltriphenylphosphonium bromide which, in turn, can be reacted with the 3-(substituted‘phenyl)-3cyclopropylpropenal in the presence of n-but^llithium to

AP 0 0 0 0 5 4

-10yield a 1-(substituted phenyl)-l-cyclopropyl-4-(substituted phenyl)butadiene. Hydrogenation of this butadiene produces the saturated insecticidal compounds of Formula I. Example 4 details the synthesis of l-(4-chlorophenyl)-l-cyclopropyl-4-(3-phenoxyphenyl)butane,

Compound 88 of Table 1, by this method.

Alternatively, the saturated, hydrocarbon compounds may be synthesized by reacting an appropriately substituted benzaldehyde with ethoxycarbonylmethyl^netriphenylphosphorane, producing the corresponding ethyl 3-(substituted aryl)acrylate. Reduction of this ester with lithium aluminum hydride yields the corresponding 3-(substituted aryl)propanol. Reaction of this alcohol with phosphorous tribromide yields the propyl bromide which, in turn, is reacted with triphenylphosphine, ‘ . I producing the corresponding 3-(substituted aryl)propyltriphenylphosphonium bromide. The intermediate 1-(substituted phenyl)-l-cyclopropyl-4-(substituted aryl)-lbutene is prepared by reaction of the phosphonium bromide with the appropriate substituted-phenyl cyclopropyl ketone in the presence of n-butyllithium.

Catalytic hydrogenation with Raney nickel completes the synthesis. By this method 1-(4-chlorophenylJ-l-cyclopropyl-4- (3-phenoxyphenyl)butane, Compound 88 of Table 1, was synthesized as described in Example 7.

Certain substituted-phenyl cyclopropyl ketones, e.g., 4-chlorophenyl cyclopropyl ketone, are·commercially available. Others can be synthesized by starting with an appropriately substituted benzoic acid which can t

be converted to the acid chloride by the usual methods, e.g., by reaction with oxalyl chloride. Reaction of the acid chloride with N-methoxy-N-methylamine hydrochloride yields the corresponding substituted N-methoxy-N-methylbenzamide. The desired substituted-phenyl cyclopropyl ketone is then obtained by reacting the benzdmide with — 11 — cyclopropylmagnesium bromide. Example 5, Steps A-C, representative of this method, provide details for the synthesis of cyclopropyl (4-trifluoromethylphenyl) ketone.

Alternatively, the substituted-phenyl cyclopropyl ketones may be prepared by reacting cyclopropanecarboxylic acid chloride with an appropriately substituted-phenyl compound in the presence of a FriedelCrafts catalyst, e.g., aluminum chloride. In Example 6,

Step A, cyclopropanecarboxylic acid chloride is reacted with ethoxybenzene in the presence of aluminum chloride, yielding cyclopropyl (4-ethoxyphenyl) ketone.

The intermediate butadienes of the formula:

Ar-C=CH-CH=CH-Ar' wherein Ar and Ar* are defined as above are themselves insecticidal and acaricidal. Table 2 lists these compounds.

Also, the intermediate butenes of the formula:

AP 0 0 0 0 5 4

Ar-C=CH-CH₂“CH₂-Ar' wherein Ar and Ar* are defined as above are insecticidal and acaricidal. Table 3 lists these compounds. These . olefins may exist in two configurations, the E and Z isomers. In the E isomer the cyclopropyl group and the -CH₂CH₂Ar* moiety are in a cis configuration in relation

-12to the double bond and in the Z isomer these same moieties are situated in a trans configuration. In one instance an example of a Z isomer, Compound B13, was separated by rotating disk thin layer chromatography from a mixture of E and Z isomers. This enriched the residue, Compound B12, in the E isomer relative to the z isomer. Comparisons of the insecticidal data for these compounds indicate that E isomers are significantly more active than the Z isomers.

The following examples provide additional details of the synthetic methods used to prepare the insecticidal ethers, thioethers, and hydrocarbons of this invention. Tables 1, 2, and 3 list these compounds. The compound numbers shown in each example are those assigned in these tables.

k

Example 1

Synthesis of (4-fluoro-3-phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl ether [Compound 16]

Step A Synthesis of 1-Cyclopropyl-1-(4-chlorophenyl)ethene as an intermediate

Under a nitrogen atmosphere, a stirred suspension of 1.6 grams (0.063 mole) of 97% sodium hydride in 50 mL of dimethyl sulfoxide was heated at 80°C for 90 minutes.

The reaction mixture was cooled to ambient temperature, and 20.8 grams (0.056 mole) of methyl triphenylphosphonium bromide was added portionwise. Upon completion of addition, an additional 20 mL of dimethylsulfoxide was added to the reaction mixture which was then stirred at ambient temperature for 30 minutes and then at 60°C for 3 0 minutes. The reaction mixture was cooled to ambient temperature, and 10.2 gram^(0.056 mole) of cyclopropyl (4-dhlorophenyl) ketone was added

-13portionwise during a 15 minute period. Upon completion of addition, an additional 20 mL of dimethylsulfoxide was added, and the reaction mixture was stirred at ambient temperature for 18 hours. The reaction mixture was stirred with 100 mL of water which caused the precipitation of the by-product triphenylphosphine oxide. The aqueous layer and the precipitate were extracted with five 100 mL portions of hexane. The combined extracts were washed first with 80 mL of 1:1 dimethyl10 sulfoxide:water and then with 80 mL of an aqueous, saturated sodium chloride solution. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated, yielding 10.9 grams of residual oil. A 1.2 gram sample from a previous run of this reaction was combined with the product of the reaction, and the 12.1 gram sample was distilled under reduced pressure, yielding 8.2 grams of 1-cyclopropyl-l-(4chlorophenyl)ethene; b.p. 100-105°C/34 mm. The nmr and ir spectra were consistent with the proposed structure.

Step B Synthesis of 2-cyclopropyl-2-(4-chlorophenyl)ethanol as an intermediate

Under a nitrogen atmosphere, a stirred solution of 3.5 grams (0.019 mole) of 1-cyclopropyl-l-(4-chloro25 phenyl)ethene in 10 mL of distilled tetrahydrofuran was cooled to 0°C, and 29.5 mL (0.020 mole) of 0.68 M bis(3methyl-2-butyl)borane in tetrahydrofuran was added via syringe during a 10 minute period. Upon completion of addition, the reaction mixture was stirred at 0°C for

1.3 hours, at ambient temperature for 2.5 hours, and at

60°C for 0.75 hour. The reaction mixture was cooled to 0°C, and 17 mL of methanol, 8.8 mL of aqueous 10% sodium hydroxide solution, and 8.0 mL of aqueous 30% hydrogen

J peroxide solution were sequentially added. Upon complete tion of addition, the reaction mixture was stirred at

AP 0 0 0 0 5 4

-14ambient temperature for 18 hours. The reaction mixture was heated at 60°C for 30 minutes and then was cooled, after which 30 mL of an aqueous solution saturated with potassium carbonate was added. The aqueous layer was separated and extracted with three 30 mL portions of diethyl ether. The organic materials were combined and washed with 30 mL of an aqueous, saturated potassium carbonate solution. The organic layer was dried with magnesium sulfate/potassium carbonate and filtered. The filtrate was concentrated under reduced pressure, yielding 3.8 grams of 2-cyclopropyl-2-(4-chlorophenyl)ethanol. The nmr and ir spectra were consistent with the proposed structure.

Step C Synthesis of (4-fluoro-3-phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl ether

A stirred suspension of 0.1 gram (0.0044 mole) of sodium hydride in 5 mL of tetrahydrofuran was cooled to 0°C, and a solution of 0.8 gram (0.0041 mole), of 2cyclopropyl-2-(4-chlorophenyl)ethanol in 2.5 mL of tetrahydrofuran was added via syringe during a two minute period. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature where it stirred for 30 minutes and then was heated to 55°C where it stirred for 1.5 hours. The reaction mixture was cooled to ambient temperature, and a solution of 1.0 gram (0.0043 mole) of (4-fluoro-3-phenoxyphenyl)methyl chloride in 2.5 mL of tetrahydrofuran was added via syringe. Upon completion of addition, the reaction mixture stirred at ambient temperature for 20 hours and then was warmed to 60°C where it stirred for 30 minutes. The reaction mixture was cooled, and 15 mL of water was added. The aqueous layer was removed and extracted with three 25 mL portions of hexanes. The organic I materials were combined and dried with magnesium sulfate. The

-15mixture was filtered, and the filtrate was concentrated under reduced pressure to a residual oil. The oil was purified by rotating disk thin layer chromatography using 5-10% ethyl acetate in hexanes for elution. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.65 gram of (4-fluoro3-phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl ether. The nmr and the ir spectra were consistent with the proposed structure.

Example 2

Synthesis of (4-fluoro-3-phenoxyphenyl)methyl

2-cyclopropyl-2-(4-chlorophenyl)ethyl thioether [Compound 21)

Step A Synthesis of 2-cyclopropyl-2-(4-chlgrophenyl)ethyl thiolacetate as an intermediate

A stirred solution of 11.7 grams (0.045 mole) of triphenylphosphine in 75 mL of dry tetrahydrofuran was ₀ cooled to 0°C, and 9.0 grams (0.045 mole) of diisopropyl azodicarboxylate was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature where it stirred for 30 minutes. Successively, 4.4 grams (0.022 mole) of 2-cyclopropyl-25 (4-chlorophenyl)ethanol (prepared in Example 1, Step B) and 3.4 grams (0.045 mole) of thiolacetic acid were then added. The exothermic reaction caused the reaction mixture temperature to rise to 39°C. After cooling to ambient temperature the reaction mixture was stirred for

16 hours. The reaction mixture was then concentrated under reduced pressure to a residual oil. The oil was . subjected to chromatography on silica gel using methylene chloride:heptane (1:4) as eluant. The appropriate fractions were combined and concentrated under reduced pressure, yielding 4.6 grams of 2-cyclopropyl-2-(4-16chlorophenyl)ethyl thiolacetate as an oil. The nmr and the ir spectra were consistent with the proposed structure.

Step B Synthesis of 2-cyclopropyl-2-(4-chlorophenyl)ethanethiol as an intermediate

I

Under a nitrogen atmosphere a mixture of 1.2 grams (0.032 mole) of lithium ^luminum hydride in dry tetrahydrofuran was stirred, and a solution of 4.1 grams (0.016 mole) of 2-cyclopropyl-2-(4-chlorophenyl) ethyl thiolacetate in 3 mL of tetrahydrofuran was added dropwise. Upon completion of addition, the reaction mixture was stirred at ambient temperature for 16 hours. Water was then carefully added dropwise to destroy excess lithium aluminum hydride. After the hydride was destroyed, 50 mL of additional water was added. The reaction mixture was extracted with several portions of diethyl ether. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, yielding 3.4 grams of 2-cyclopropyl-2-(4-chlorophenyl) ethanethiol. The nmr and the ir spectra were consistent with the proposed structure.

Procedures analogous to Steps A and B are reported in Tetrahedron Letters. Vol. 22, No. 33, p 3119-3122, 1981.

Step C Synthesis of (4-fluoro-3-phenoxyphenyl) methyl

2-cyclopropyl-2- (4-chlorophenyl) ethyl thioether

This compound was prepared in a manner analogous to that of Example 1, Step C, using 1.0 gram (0.0046 mole) .of 2-cyclopropyl-2-(4-chlorophenyl) ethanethiol, 0.97 gram (0.0041 mole) of (4-fluoro-3-phenoxyphenyl)methyl chloride, and 0.22 gram (0.0055 mole) of sodium hydride in 12 mL of dry tetrahydrofuran. The yield of (4>

) ^;

-17fluoro-3-phenoxypheny1)methyl 2-cyclopropyl-2-(4-chlorophenyl)ethyl thioether was 1.2 grams as an oil. The nmr and the ir spectra were consistent with the proposed structure.

Example 3

Synthesis of the stereoisomers (A) and (B) of (4-fluoro-3-phenoxypheny1) methyl 2-cyclopropy12-(4-chlorophenyl}ethyl ether [Compounds 17 and 18, respectively]

Step A Synthesis of 2-[(4-chlorophenyl)cyclopropylmethylene] -1,3-dithiane as an intermediate

A solution of 16.0 grams (0.083 mole) of 2-trimethylsilyl-1,3-dithiane in 80 mL of tetrahydrofuran was cooled to 0°C, and 39 mL (0.083 mole) of n-butyllithium (2.1 M in hexane) was added. The reaction mixture was stirred for 15 minutes, and 15.0 gra%s (0.083 mole) of

2o cyclopropyl (4-chlorophenyl) ketone in 40 mL of tetrahydrofuran was added via syringe during a five minute period. Upon completion of addition, the reaction mixture was. stirred at 0°C for 15 minutes and then was allowed to warm for 30 minutes. The reaction mixture was stirred with 100 mL of an aqueous solution saturated with sodium chloride, and then the two phases were separated. The aqueous phase was extracted with one portion of diethyl ether. The ether extract was combined with the organic phase, and this mixture was dried ₃₀ with magnesium sulfate and filtered through a pad of silica gel. The filtrate was concentrated under reduced .pressure, yielding 24.0 grams of 2-[(4-chlorophenyl)cyclopropylmethylene]-l,3-dithiane as a solid, m.p. 91-95°C. The nmr spectrum was consistent %ith the proposed structure. ' - \

AP 0 0 0 0 5 4

-18St ip B Synthesis of methyl 2-cyclopropy1-2-(4-chlorophenyl)acetate as an intermediate

A mixture of 10.0 grams (0.036 mole) of 2-[(4chlorophenyl)cyclopropylmethylene]-1,3-dithiape, 24.0 grams (0.086 mole) of mercury (II) chloride, and 5 mL of water in 50 mL of methanol was stirred at ambient temperature for 18 hours. The reaction mixture ias heated at reflux for one hour, cooled, and then was diluted with diethyl ether. The mixture was filtered through diatomaceous earth and then was dried with magnesium sulfate. The mixture was filtered through silica gel, and the filtrate vas concentrated under reduced pressure, yielding 5.9 grams of methyl 2-cyclopropyl-2-(4chlorophenyl)acetate as an oil. The nmr spectrum was consistent with the proposed structure. The reaction was run again to produce an additional 7.1 grams of the acetate.

Step C Synthesis of 2-cyclopropyl-2-(4-chlotophenyl)acetid acid as an intermediate

A mixture *f 13.0 grams (0.058 mole) of methyl 2cyclopropyl-2-(4-chlorophenyl)acetate and 5.0 grams of an aqueous, 5G% sodium hydroxide solution in 50 mL of methanol was itirred at ambient temperature for 18 hours. The reaction mixture was diluted with 150 mL of water, and tie solution was decanted from a solid residue. Th£ liquid portion was washed witH three portions of diethyl ether. The combined ether washes were, in turn, washed with an aqueous, dilute sodium hydroxide solution. The combined aqueous layers were mhde acidic by the slow addition of aqueous, 10% hydrochloric acid. .The acidified mixture was extracted with five portions of methylene chloride. The combined extracts were dried with sod inm sulfate and filtered. The filtrate was concentrAted under reduced pressure, yielding.7.4 grams

-19of 2-cyclopropyl-2-(4-chlorophenyl)acetic acid as a solid, m.p. 95-96°C

Step D Synthesis of (S)-4-(1-methylethyl)-2-oxazol5 idinone as an intermediate

A mixture of 9.4 grams (0.091 mole) of (S)-2-amino3-methyl-l-butanol, 36 grams (0.0546 mole) of 85% potassium hydroxide, 175 mL of toluene, and 240 mL of water was stirred rapidly as 140 mL (0.273 mole) of a toluene

IQ solution containing 20% phosgene was added dropwise during a 15 minute period. Upon completion of addition, the resulting hot solution was stirred an additional 30 minutes. The reaction mixture was cooled, and the organic and aqueous layers were separated. The organic layer was washed with water and dried with magnesium sulfate. The mixture wa0 filtered, and the filtrate was concentrated under reduced pressure, yielding 15.0 grams of (S)-4-(1-methylethyl)-2-oxazolidinone as a solid. Recrystallization from cyclohexane yielded purer com20 pound, m.p. 71.5-72.5°C.

Step E Synthesis of (S)-N-[2-(4-chlorophenyl)-2-cyclopropylacetyl]-4-(1-methylethyl)-2-oxazolidinone and separation of its diastereomers (A) and (B) for use as intermediates

A solution of 3.3 grams (0.016 mole) of 2-cyclopropyl-2-(4-chlorophenyl)acetic acid (prepared in Step C), 1.36 mL (0.016 mole) of oxalyl chloride, and two drops of Ν,Ν-dimethylformamide in 70 mL of diethyl ether ₃₀ was stirred at 0°C for one hour. The reaction mixture was then allowed to warm to ambient temperature where it stirred for one hour.

In a separate reaction vessel a stirred solution of 2.0 grams (0.016 mole) of (S)-4-(1-methylethyl)-2oxazolidinone in 50 mL of tetrahydrofuran was cooled to

AP 0 0 0 0 5 4

-20-73°C, and 6.25 mL (0.016 mole) of Q-butyllithium (2.5 molar in hexane) was added dropwise. Upon completion of addition, the reaction mixture was stirred for 30 minutes, and then the 2-cyclopropyl-2-(4-chlorophenyl)acetyl chloride, prepared above, was added dropwise during several minutes. Upon completion of addition, the reaction mixture was stirred for an additional 30 minutes and then was poured into water. The,organic layer was separated and washed with one portion of aqueous sodium bicarbonate. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residual oil. The oil was subjected to chromatography on silica gel using hexane:diethyl ether (3:1) as eluant. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.85 gram of diastereomer (A) and 0.8 gram of diastereomer (B) of (S)-N-(2L(4-chlorophenyl) -2-cyclopropylacetyl]-4- (1-methylethyJ.) -2-oxazolidinone. Upon standing, diastereomer (A) crystallized to a solid, m.p. 61-64°C. ¹

Step F Synthesis of stereoisomer (A) of 2-cyclopropyl2-(4-chlorophenyl)ethanol as an intermediate

A stirred suspension of 0.31 gram (0.008 mole) of lithium aluminum hydride in 5 mL of tetrahydrofuran was cooled to 0°C, and 0.85 gram (0.0026 mole) of diastereomer (A) of (S)-N-[2-(4-chlorophenyl)-2-cyclopropylacetyl ]-4-(1-methylethyl)-2-oxazolidinone was added. Upon completion of addition, the reaction mixture was stirred for 4 5 minutes, and then 15 ^lmL of hexane was added to the reaction mixture. This was followed by the careful addition of 0.3 mL of water, 0.3 mL of aqueous 15% sodium hydroxide, and 0.9 riiL of water. The reaction mixture was stirred with magnesium sulfate and filtered through a pad of silica gel. The filtrate

-21was concentrated under reduced pressure to a residual oil. The oil was subjected to chromatography on silica gel using diethyl ether:hexane (1:1) as eluant. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.4 gram of stereoisomer (A) of 2-cyclopropyl-2-(4-chlorophenyl)ethanol as an oil.

Step G Synthesis of stereoisomer (A) of (4-fluoro-3phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chloro10 phenyl)ethyl ether

Under a nitrogen atmosphere a suspension of 0.06 gram (0.0024 mole) of 97% sodium hydride in 2.2 mL of dimethyl formamide was stirred, and a solution of 0.40 gram (0.002 mole) of stereoisomer (A) of 2-cyclopropyl15 2-.(4-chlorophenyl) ethyl ethanol in 1.0 mL of dimethylformamide was slowly added. Upon completion of addition, the reaction mixture was stirred for 1.5 hours, and then a solution of 0.46 gram (0.0019 mole) of (4fluoro-3-phenoxyphenyl)methyl chloride in 1.0 mL of dimethylformamide was added. Upon completion of addition, the reaction mixture was stirred for one hour, and then 2-3 mL of water was added. The mixture was poured into 75 mL of aqueous, 10% hydrochloric acid'and then was extracted with two 50 mL portions of hexane. The combined hexane layers were washed with 25 mL of a saturated, aqueous solution of sodium chloride. The organic layer was dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residual oil. The oil was subjected to rotating disk thin layer chromatography on silica gel using diethyl ether: hexane (19:1) as eluant. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.55 gram of stereoisomer (A) of (4fluoro-3-phenoxyphenyl.)methyl 2-cyclopropyl-2-(4-chloro35 phenyl)ethyl ether as an; oil. The nmr spectrum was consistent with the proposed structure. (α]£⁵=^( + ) 22.19°

-2210

Step H Synthesis of stereoisomer (B) of 2-cyclopropyl

2-(4-chlorophenyl)ethanol as an intermediate

This compound was prepared in a manner analogous to that of Step F, using 0.80 gram (0.0025 mole) of diastereomer (B) of (S) -N-(2-(4-chlorophenyl) -2-cyclopropylacetyl]-4-(1-methylethyl)-2-oxazolidinone (prepared in Example 3, Step E) and 0.30 gram (0.008 mole) of lithium aluminum hydride in 15 mL of tetrahydrofuran. The yield of stereoisomer (B) of 2-cyclopropyl-2-(4chlorophenyl)ethanol was 0.4 5 gram as an oil'.

Step I Synthesis of stereoisomer (B) of (4-fluoro-3phenoxyphenyl)methyl 2-cyclopropyl-2-(4-chlorophenyl)

This compound was prepared in a manner analogous to t

that of Step G, using 0.40 gram (0.0020 mole) of stereoisomer (B) of 2-cyclopropyl-2-(4-rchlorophenyl)ethanol (prepared in Step H), 0.*46 gram (0.0019 mole) of (4fluoro-3-phenoxyphenyl)methyl chloride, and' b. 06 gram (0.0024 mole) of sodium hydride in 4.2 mL of*dimethylformamide. The yield of stereoisomer (B) of, (4-fluoro3-phenoxypheny 1) methyl 2-cyclopropyl-2- (4-chjioropheny 1) ethyl ether was 0.56 gram as an oil. The nmr spectrum was consistent with the proposed structure. .

[q]25= ₍_) 20.64°

Example 4

Synthesis of 1-(4-chlorophenyl)-1-cyclbpropyl 4- (3-phenoxypheny1) butane [Compound 88] ^:

Step A Synthesis of 1-(4-chlorophenyl)-1-cyclopropyl2-propen-l-ol as an intermediate

A 1.0 M solution of yinylmagnesium bromide in tetra hydrofuran (110 mL, 0.11 mole) was stirred, and a solu* ·* tion of 18.1 grams (0.1 mole) of commercially available

-234-chlorophenyl cyclopropyl ketone in 50 mL of dry tetrahydrofuran was added dropwise during a one hour period. The exothermic reaction caused the reaction mixture to warm to 45°C. Upon completion of addition, the reaction mixture was stirred for two hours as it cooled to ambient temperature. The reaction was quenched with the addition of 50 mL of a saturated, aqueous solution of ammonium chloride. The mixture was extracted with two 50 mL portions of diethyl ether. The combined extracts were dried with potassium carbonate and filtered. The filtrate was concentrated under reduced pressure, yielding 20.0 grams of 1-(4-chlorophenyl)-l-cyclopropyl-2propen-l-ol.

Step B Synthesis of 3-(4-chlorophenyl)-3-cyclopropylt propenal as an intermediate To a stirred solution of 40.3 grams (0.192 mole) of pyridinium chlorochromate in 210 mL of methylene chloride was added a solution of 20.0 grams (0.096fmole) of

2o 1-(4-chlorophenyl)-l-cyclopropyl-2-propen-l-ol in 25 mL of methylene chloride in one portion. Upon completion of addition, the reaction mixture was stirred for two hours. A supernatent layer was decanted from a residue, and the residue was extracted with diethyl ether. The supernatent layer was combined with the ethfer extracts, and the combination was washed with two 100 mL portions of an aqueous 5% sodium hydroxide solution, 100 mL of an aqueous 5% hydrochloric acid solution, and then with 50 mL of an aqueous solution saturated with sodium bicar₃₀ bonate. The organic layer was dried with sodium sulfate and. filtered. The filtrate was concentrated under _%reduced pressure to a residue. The residue was subjected to column chromatography on silica gel'. Elution was accomplished using 5% diethyl ether in hekane. The appropriate fractions were combined and concentrated

-24under reduced pressure, yielding 6.8 grains of 3-(4chlorophenyl)-3-cyclopropylpropenal.

Step C Synthesis of 3-phenoxyphenylmethyltriphenyl5 phosphonium chloride as an intermediate

A stirred solution of 5.0 grams (0.0228 mole) of 3phenoxyphenylraethyl chloride and 5.6 grams (O'.0217 mole) of triphenyl phosphine in 50 mL of dry toluene was heated at reflux for 8 hours. The reaction mixture was cooled and filtered to collect a solid. The solid was washed with pentane and dried, yielding 4.6 grams of 3phenoxyphenylmethyltriphenylphosphonium chloride. The nmr spectrum was consistent with the proposed structure.

Step D Synthesis of 1-(4-chlorophenyl)-1-cyclopropyl4-(3-phenoxyphenyl)-1,3-butadiene (Compound A5) as an intermediate

A stirred solution of 4.4 mL (0.011 mole): of flbutyllithium (2.5 molar in hexane) in 100 mL'of dry tetrahydrofuran was cooled to -78°C, and 4.6 grams (0.01 mole) of 3-phenoxyphenylmethyltriphenylphosphonium chloride was quickly added. Upon completion ’of addition, the reaction mixture was stirred at -78°C for one hour and then was allowed to warm to -20°C where it stirred for one hour. The reaction mixture was cooled to -78°C, and 2.1 grams <0.01 mole) of 3-(4-chlorophenyl)-3-cyclopropylpro^enal (prepared in Step B) in 10 mL of tetrahydrofuran was added during a 15 minute period. Upon completion of addition, the reaction mixture was allowed to warm to ambient ten.peratdre where it stirred for two hours. The reaction was quenched with the addition of 15 mL of aqueous 10% hydrochloric acid solution. The mixture was extracted with didthyl ether. The combined extracts were dried with sodium sulfate and filtered. The filtrat’e was concentrated under reduced

-25pressure to a residue. The residue was subjected to column chromatography on silica gel. Elution was accomplished using 5% diethyl ether in hexane. The appropriate fractions were combined and concentrated under reduced pressure, yielding 3.2 grams of l-(4-chlorophenyl) -l-cyclopropyl-4-(3-phenoxyphenyl) -1,3-butadiene.

Step E Synthesis of 1-(4-chlorophenyl)-1-cyclopropyl4-(3-phenoxyphenyl)butane (Compound 88)

1q A mixture of 2.3 grams (0.006 mole) of l-(4-chlorophenyl) -l-cyclopropyl-4-(3-phenoxyphenyl) -1,3-butadiene, 2.3 grams (0.002 mole) of 10% palladium on carbon, 0.25 gram (0.0002 mole) of tris(triphenylphosphine)rhodium (I) chloride, and 25 mL of benzene in 100 mL of ethanol was hydrogenated at 40°C using a Parr hydrogdnator.

k

Upon completion of the uptake of the theoretical amount of hydrogen (two hours) , the reaction mixturd was cooled and filtered. The filtrate was concentrated ’under reduced pressure to a residue. The residue was taken up

2q in hexane and filtered. The filtrate was dfied with sodium sulfate and filtered again. The filtrate was concentrated under reduced pressure to a residue. The residue was subjected to rotating disk thin layer chromatography. Elution was accomplished using 20% toluene in hexane. The appropriate fractions were combined and concentrated under reduced pressure, yielding

I ,

0.52 gram of 1-(4-chlorophenyl) -l-cyclopropyl-4-(3phenoxyphenyl)butane as an oil. The nmr spectrum was consistent with the proposed structure.

• I

Example 5 , Synthesis of 1-cyclopropyl-l-(4-trifluorometliylphenyl)4- (4-f luoro-3-phenoxyphenyl) butan4 [Compound 99] « i )

(

-26Step A Synthesis of 4-trifluororaethylbenzoyl chloride as an intermediate

A stirred solution of 20.0 grams (0.105 mole) of 4trifluoromethylbenzoic acid and four drops of dimethylformamide in 300 mL of methylene chloride was cooled to 0-l0°C, and 14.7 grams (0.116 mole) of oxalyl chloride was added. Upon completion of addition, the' reaction mixture was allowed to warm to ambient temperature where it stirred for 18 hours? The reaction mixture was then concentrated under reduced pressure, yielding 21.9 grams of 4-trifluoromethylbenzoyl chloride as a semi-solid.

The reaction was repeated. ¹

Step B Synthesis of N-methoxy-N-methyl-4-trifluoromethylbenzamide as an intermediate

To a stirred suspension of 19.9 grams (0.204 mole) of N-methoxy-N-methylamine hydrochloride in 500 mL of methylene chloride was added 39.3 grams (0.3&8 mole) of triethylamine. Upon completion of addition,* the reaction mixture was stirred for ten minutes, ahcl a solution of 38.4 grams (0.185 mole) of 4-trifluoromethylbenzoyl chloride in 25 mL of methylene chloride was added dropwise. Upon completion Of addition, the reaction mixture was stirred at ambient temperature for 18 hours. The reaction mixture was then stirred vigorously with 300 mL of water. The aqueous layer was separated fpom the organic layer and washed with three portions of methylene chloride. The washes were combined with the organic layer, and the combination was dried with magnesium sulfate. The mixture was filtered, and the filtrate was concentrated under reduced pressure, yielding 42.5 grams » of N-methoxy-N-methyl-4-trifluoromethylbenzaiiide as an oil. The nmr spectrum was consistent with tke proposed structure. · ·

-, i <

i

-27Step C Synthesis of cyclopropyl (4-trifluoromethylphenyl) ketone as an intermediate

Under a nitrogen atmosphere a vigorously stirred solution of 42.5 grams (0.182 mole) of N-methoxy-N5 methyl-4-trifluoromethylbenzamide in 250 mL of dry tetrahydrofuran was cooled to 0-10°C, and 41’. 7 grams (0.0287 mole) of freshly prepared cyclopropyimagnesium bromide in 170 mL of tetrahydrofuran was add^d rapidly dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature where it stirred for 60 hours. The reaction mixture was then concentrated under reduced pressure to a residue. The residue was taken up in water and extracted with four portions of methylene chloride. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was passed through a pad of silica §el and was concentrated under reduced pressure yielding, 34.6 grams of cyclopropyl (4-trifluoromethylphenyl) ketone. The nmr spectrum was consistent with the proposed structure.

o

Step D Synthesis of 1-cyclopropyl-l-(4-trifluoromethylphenyl) -2-propen-l-ol as an intermediate

This compound was prepared in a manner afialogous to that of Example 4, Step A, using 10.0 grams (0.05 mole) ₅ of cyclopropyl (4-trifluoromethylphenyl) ketone and 50 mL (0.05 mole) of vinylmagnesium bromide (1.0 M in tetrahydrofuran) and 25 mL of tetrahydrofuran. The yield of 1-cyclopropyl-l-(4-trifluoromethylphenyl)-2propen-l-ol was 11.6 grams. The nmr spectrum was con0 sistent with the proposed structure.

, Step E Synthesis of 3-cyclopropyl-3-(4-trifluoromethylphenyl)propenal as an intermediate

This compound was prepared in a manner cthalogous to . that of Example 4, Step B, using 11.1 grams f0.046 mole) f

f ftp n 0 0 0 5 4

-28of 1-cyclopropyl-l-(4-trifluoromethylphenyl)-2-propen-lol and 19.7 grams (0.091 mole) of pyridinium chlorochromate in 100 mL of methylene chloride. The yield of 3-cyclopropyl-3- (4-trif luoromethylphenyl) propenal was 5.5 grams j

Step F Synthesis of 4-fluoro-3-phenoxyphenylmethanol

Ϊ as an intermediate ‘

To a stirred suspension of 1.4 grams (0.0375 mole) of lithium aluminum hydride in 50 mL of anhydrous diethyl ether was added dropwise during a one hour period a solution of 21.6 grams (0.1 mole) of 4-fluoro3-phenoxybenzaldehyde in 50 mL of anhydrous diethyl ether. Upon completion of addition, the reaction mixture was heated at reflux for 1.0 hour. The ,reaction k * mixture was cooled to 15°C, and 1.4 mL of water was cautiously added dropwise. Upon completion of addition, the reaction mixture was again cooled to 15°0, and 1.4 mL of an aqueous, 15% sodium hydroxide solution was added dropwise, followed by an additional 4.2 mL of water. The mixture was filtered through diatomaceous earth, and the filtrate was concentrated under reduced pressure, yielding 19.5 grams of 4-fluoro-3-phenoxyphenylmethanol as an oil.

Step G Synthesis of 4-fluoro-3-phenoxyphenylmethyl chloride as an intermediate

To a stirred solution of 12.6 grams (0.105 mole) of thionyl chloride and a catalytic amount of pyridine in 25 mL of toluene was added dropwise during a 45 minute period a solution of 19.5 grams (0.88 mole) of 4-fluoro, 3-phenoxyphenylmethanol ^prepared in Step F) fin 30 mL of toluene. The reaction mixture temperature was maintained at 25-35°C throughout the addition. Upon completion of addition, the reaction mixture was warmed to .{ *

t

-2945°C where it stirred for one hour. The reaction mixture was cooled and then was concentrated under reduced pressure, yielding 23.5 grams of semi-solid. The semisolid was combined with 114.2 grains of identical semi5 solid obtained from a large run of the present reaction. The 136.6 grams of semi-solid was distilled under reduced pressure. The appropriate fractions were combined, yielding 100.3 grams of 4-fluoro-3-phenoxyphenylmethyl chloride, b.p. 98-105°C/0.03-0.13 mm Hg.

Step H Synthesis of (4-fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride as an intermediate

This compound was prepared in a manner analogous to 15 that of Example 4, Step C, using 11.8 grams (0.05 mole) of 4-fluoro-3-phenoxyphenylmethyl chloride and 13.1 grams (0.05 mole) of triphenylphosphine in ldo mL of tetrahydrofuran. The yield of (4-fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride was 15.0

2q grams.

Step I Synthesis of l-cyclopropyl-l-(4-trifluoromethylphenyl)-4-(4-fluoro-3-phenoxy^henyl)-1,3butadiene (Compound A13) as an intermediate

This compound was prepared in a manner analogous to that of Example 4, Step D, using 1.7 grams (0.0069 mole) of 3-cyclopropyl-3-(4-trifluoromethylphenyl)propenal (prepared in Step E of the present example), 3.4 grams (0.0069 mole) of (4-fluoiro-3-phenoxyphenyl)methyltri₃₀ phenylphosphonium chloride (prepared in Step H of the present example), and 2.8 mL (0.0069 mole) of n-butyl. lithium (2.5 molar in hexane) in 69 mL of dry tetrahydrofuran. The yield of 1-cyclopropyl-l-(4-trifluorol methylphenyl)-4-(4-fluoro-3-phenoxyphenyl)-1J 3-butadiene ₃₅ was 1.8 grams. The nmr spectrum was consistent with the proposed structure.

AP 0 0 0 0 5 A

-30Step J Synthesis of 1-cyclopropyl-l-(4-trifluoromethylphenyl)-4-(4-fluoro-3-phenoxyphenyl)butane (Compound 99)

This compound was prepared in a manner analogous to that of Example 4, Step E, by the hydrogenation of 0.98 gram (0.0023 mole) of l-cyclopropyl-l-(4-trifluoromethylphenyl)-4-(4-fluoro-3-phenoxyphenyl)-1J 3-butadiene in the presence of 0.2 gram (0.00023 mole) o^-Raney nickel in 50 mL of ethanol. The yield of 1-cyclopropyl1-(4-trifluoromethylphenyl) -4-(4-fluoro-3-phenoxyphenyl)butane was 0.65 gram as an oil. The nmr spectrum was consistent with the proposed structure.

Example 6 ' . Synthesis of 1-cyclopropyl-l-(4-ethoxyphenyl)4- (3-phenoxyphenyl)butane i [Compound 104] f

Step A Synthesis of cyclopropyl (4-ethoxyji0enyl) ketone as an intermediate v

Under an argon atmosphere a stirred suspension of 36.7 grams (0.275 mole) of aluminum chloride·in 225 mL of carbon disulfide was cooled to 0°C, and 2^.7 mL (0.25 mole) of cyclopropanecarboxylic acid chloridd was added dropwise during a 15 minute period. During the addition and for 30 minutes after’ its completion the reaction mixture temperature was maintained at 0-15°C. Then 34.8 mL of ethoxybenzene was added dropwise during a one hour period. The reaction mixture temperature wa£ maintained at 5-10°C during this addition. Upon completion of addition, the reaction mixture was allowed to warm to a

* ambient temperature as it stirred for one hoir. Petroleum ether, 250 mL, was added to the reaction mixture, and the suspension was stirred for ten minu^s. The

Ί

I

-31solid was collected by filtration and washed with petroleum ether. The solid was returned to the reaction vessel and, with stirring, was cooled to 0-10°C while 50 mL of water was added dropwise during a 30 minute period. Upon completion of addition, the mixture was stirred until the evolution of hydrogen chloride ceased. An additional 250 mL of water was then added,'and the mixture was stirred at ambient temperature fojr 30 minutes. It was then warmed to 80°C where it stirred for an additional 30 minutes. The mixture was cooled, and a solid was collected by filtration. The solid was dissolved in methylene chloride, and the solution was dried with sodium sulfate. The mixture was filtered, and the filtrate was concentrated under reduced pressure to.a residual solid. The solid was recrystallized from heptane, yielding, in two crops, 44.0 grams of cyclo1 propyl (4-ethoxyphenyl) ketone, m.p. 67-70°C.? The nmr spectrum was consistent with the proposed structure.

!“

I

2Q Step B Synthesis of 1-cyclopropyl-l-(4-ethoxyphenyl)2-propen-l-ol as an intermediate

This compound was prepared in a manner analogous to

I that of Example 4, Step A, using 5.7 grams (0>03 mole) of cyclopropyl (4-ethoxyphenyl) ketone and 33 mL (0.033 mole) of vinylmagnesium bromide (1.0 M in tetrahydrofuran) in 30 mL of dry tetrahydrofuran. The yield of lcyclopropyl-1-(4-ethoxyphenyl)-2-propen-l-ol was 6.5 grams as an oil.

ί

Step C Synthesis of 3-cyclopropyl-3-(4-ethoxyphenyl) AP 0 0 0 0 5 4 propenal as an intermediate

This compound was prepared in a manner analogous to that of Example 4, Step B, using 6.5 grams (0.029 mole)

I

-32mL of methylene chloride. The yield of 3-cyclopropyl-3(4-ethoxyphenyl)propenal was 4.2 grams as an oil.

Step D Synthesis of l-cyclopropyl-l-(4-ethoxyphenyl)4-(3-phenoxyphenyl)-1,3-butadiene (Compound A15) as an intermediate

This compound was prepared in a manner analogous to that of Example 4, Step D, using 4.2 grams (0.019 mole) of 3-cyclopropyl-3-(4-ethoxyphenyl)propenal, 9.1 grams (0.019 mole) of 3-phenoxyphenylmethyltriphenylphosphonium bromide (prepared as in Example 4, Step H), and 7.5 mL (0.019 mole) of n-butyllithium (2.5 M in tetrahydrofuran) in 100 mL of dry tetrahydrofuran. The yield of 1-cyclopropyl-l-(4-ethoxyphenyl)-4-(3-phenoxyphenyl)-1,3-butadiene was 2.5 grams.

Step E Synthesis of l-cyclopropyl-l-(4-ethoxyphenyl)4-(3-phenoxyphenyl)butane (Compound 104)

This compound was prepared in a manner analogous to that of Example 4, Step E, by the hydrogenation of 1.5 grams (0.0039 mole) of 1-cyclopropyl-l-(4-ethoxyphenyl) 4-(3-phenoxyphenyl)-1,3-butadiene in the presence of 0.34 gram of Raney nickel in 70 mL of ethanol. The yield of 1-cyclopropyl-l-(4-ethoxyphenyl)-4-(3-phenoxyphenyl ) butane was 1.2 grams as an oil. The nmr spectrum was consistent with the proposed structure.

Example 7

Synthesis of 1-(4-chlorophenyl)-1-cyclopropyl4 - (3-phenoxyphenyl) butane [Compound 88]

Step A Synthesis of ethyl 3-(3-phenoxyphenyl)acrylate

To a stirred solution of 23.4 g (0.188 mole) of 3phenoxybenzaldehyde in 175 mL of 1,4-dioxane was added

I ' T

-3345.2 grans (0.130 mole) of ethoxycarbonylmethylenetriphenylphosphorane in one portion. The reaction was allowed to stir at ambient temperature overnight. The solvent was evaporated under reduced pressure, leaving a residue which was dissolved in ethyl acetate. Approximately 30 grams of silica gel was mixed with this solution. This solvent was evaporated under reduced pressure, and the silica gel was placed in a sintered glass filter. The silica gel was eluted with 1000 mL of heptane/ethyl acetate (3:1). The solvent was evaporated under reduced pressure, leaving an oil. This oil was dissolved in 150 mL of heptane/ethyl acetate (9:1), treated with 15 grams of silica gel, and filtered. The filtrate was evaporated under reduced pressure, leaving

26.7 grams of ethyl 3-(3-phenoxyphenyl)acrylate as an oil. The nmr spectrum was consistent with the proposed structure.

t

Step B Synthesis of 3-(3-phenoxyphenyl)propanol

2o ^{To a} stirred mixture of 7.4 grams (0.196 mole) of lithium aluminum hydride in 300 mL of dry diethyl ether under a nitrogen atmosphere was added 26.2 grams (0.098 mole) of ethyl 3-(3-phenoxyphenyl)acrylate in 300 mL of dry diethyl ether. The addition required 90 minutes to complete, and the reaction mixture was stirred overnight at ambient temperature. It was then cooled in an ice/ water bath, and sequentially 14 mL of water', 14 mL of a 15% aqueous solution of sodium hydroxide, and 42 mL of water were all added dropwise. This mixture was fil,₀ tered, and the filtrate was dried over anhydrous sodium sulfate. After being filtered, the solvent was evap• orated under reduced pressure, leaving 21.9 grams of 3(3-phenoxyphenyl)propanol as an oil. The nmr spectrum was consistent with the proposed structure.

AP 0 0 0 0 5 4

-34Step C Synthesis of 3-(3-phenoxyphenyl)propyl bromide

To a mixture of 21.0 grams (0.092 mole) of 3-(3phenoxyphenyl)propanol and 1 mL of pyridine which had been cooled to 0°C was added dropwise during a 20 minute period 8.27 grams (0.031 mole) of phosphorus tribromide. This mixture was stirred at 0°C for 90 minutes and then at ambient temperature overnight. The reaction mixture was then diluted with 200 mL of diethyl ether, and the solution was washed successively twice with 50 mL of water, four times with 25 mL of a saturated, aqueous solution of sodium bicarbonate, once with 50 mL of water, and once with an aqueous solution of sodium chloride. After being dried over anhydrous sodium sulfate and filtered, the solvent was evaporated under reduced pressure, leaving 18.9 grams of 3-(3-phenoxyphenyl) propyl bromide as an oil. The nmr spectrum was consistent with the proposed structure.

Step D Synthesis of 3-(3-phenoxyphenylJpropyltri2Q phenylphosphonium bromide

Under nitrogen a mixture of 2.9 grams (0.01 mole) of

3-(3-phenoxyphenyl)propyl bromide and 2.9 grams (0.01 mole) of triphenylphosphine in 25 mL of acetonitrile was heated at reflux overnight. The solvent was evaporated ₂₅ under reduced pressure. Toluene was added to the residue, and this mixture was heated at reflux for 90 minutes during which a solid formed. Filtration yielded 4.2 grams of 3-(3-phenoxyphenyl)propyltriphenylphosphonium bromide, m.p. 198-200°C.

Step E Synthesis of 1-(4-chlorophenyl)-1-cyclopropyl. 4-(3-phenoxyphenyl)-1-butene (Compound B7)

Under an argon atmosphere a slurry of 4.2 grams (0.0076 mole) of 3-phenoxyphenyl)propyltriphenylphosphonium bromide in 75 mL of freshly distilled tetraJD ¹ hydrofuran was cooled to 0°C with stirring. To this

-35mixture was added 5.4 mL (0.0079 mole ) of a 1.55 M solution of n-butyllithium in hexanes in 0.5 mL portions using a syringe during a 20 minute period. An additional 2.0 mL (0.0031 mole) of the n-butyllithium solu5 tion was then added slowly, causing a red solution to form. This solution was allowed to warm to ambient temperature at which it was stirred for 60 minutes.

This solution was again cooled to 0°C, and 1.3 grams (0.0072 mole) 4-chlorophenyl cyclopropyl ketgne in 5 mL q of tetrahydrofuran was added portionwise using a syringe. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature. A precipitate formed. After two hours the reaction mixture was filtered. To the filtrate was added 1 mL of

- water with stirring to decompose any residual n-butyllithium. The filtrate was dried over anhydrous sodium sulfate and was filtered. The filtrate was evaporated under reduced pressure, leaving a mixture of.a solid and an oil as the residue. To this residue was added θ heptane/ethyl acetate (1:2) with stirring. A solid was removed by filtration, and the filtrate was doncentrated under reduced pressure. 'Additional solid was removed by filtration from the concentrated solution. The filtrate was placed on a column of silica gel, eluting with 500 ₅ mL of heptane/ ethyl acetate (9:1). The appropriate fractions were combined, and the solvent was evaporated under reduced pressure, yielding 1.2 grams of 1-(4chlorophenyl)-l-cyclopropyl-4-(3-phenoxyphenyl)-1-butene as an oil. The nmr spectrum was consistent with the proposed structure.

Analysis for C25H23CIO Calc'd: C 80.09; H 6.18;

Found: C 80.15; H 5.98.

APO00054

-36Step F Synthesis of 1-(4-chlorophenyl)-1-cyclopropyl4-(3-phenoxyphenyl)butane (Compound 33)

This compound was prepared in a manner analogous to that of Example 4, Step E, by hydrogenation of 1.0 gram (0.0027 mole) of 1-(4-chlorophenyl)-l-cyclopropyl-4-(3phenoxyphenyl)-1-butene in the presence of 0.35 gram of

J

Raney nickel in 75 mL of ethanol. This procedure yielded 0.8 gram of l-(4-chlorophenyl)-l-cyclopropyl-4(3-phenoxyphenyl)butane as an a oil. The nmr| spectrum was consistent with the proposed structure.

In accordance with the composition aspect of the invention, the compounds are generally not applied full strength but are typically applied as formulations which may be applied as such or further diluted for applicak tion. Typical formulations include compositions of the active ingredient in combination with one or more agriculturally acceptable adjuvants, carriers or ^diluents, preferably with a surface active agent, and Optionally with other active ingredients. Suitable formulations include solid compositions such as dusts, wettable powders, and granules or liquid compositions such as solutions, dispersions, suspensions, and emulsifiable concentrates, the choice varying with the type of pest and environmental factors present at the particular locus of infestation.

A typical formulation may vary widely in concentration of active ingredient and other ingredients depending upon the particular agent used, the additives and carriers used, other active ingredients, the desired mode of application, and numerous other factors well known to those skilled in formulating compositions for use in agriculture. V

With due consideration, to these factors, |;he active ingredient of a typical formulation may, for 'example,

-37comprise 0.01 percent to 1 percent by weight up to about 95 percent by weight, preferably 1 percent up to 90 or 95 percent by weight, of the formulation. Agriculturally acceptable carriers, diluents, adjuvants, sur5 face active agents, and optionally other suitable active ingredients comprise the balance of the formulation.

Thus a typical formulation may contain from Q.01 to 95 (preferably 1 to 95) percent by weight active ingredient, from 0 to 30 percent by weight surface active agent, and from 5 to 99.99 (preferably 5 to 99) percent by weight of an inert agriculturally acceptable carrier or diluent.

Provided below is a general description of exemplary types of formulations which may be employed for applica15 tion of the compounds of the present invention.

I

SOLID OR DRY FORMULATIONS

Dry formulations are fixtures of a liquid, or solid active ingredient with a solid carrier to form a particulate product comprising discrete solid particles of

2o various sizes. Solid or dry compositions may take the form of dusts, wettable powders and granules having average particle sizes varying from about 5 microns to about 5000 microns. These compositions employ solid or dry carriers and/or diluents which may be selected from one or more of the following:

1. Attapulgite Clay: Characterized as hydrated aluminum-magnesium silicate, with or without free water, and possessing sorptive capacity of at least 35% w/w.

2. Kaolin or Kaolinite Clay: Characterized as 2Q hydrated aluminum silicate, and including the species dickite, nakrite, and hailoysite, and further character. ized by having low values for cation exchange capacity.

3. Montmorillonite: Characterized as hydrous aluminum silicate derived by natural modification of mica and pyrophyllite, and further sub-divided into swelling (sodium form) and non-swelling (calcium form).

AP 0 0 0 0 5 4 . -384. Pyrophyllite (Talc): Characterized as hydrous magnesium or aluminum silicate and having neutral to basic pH, and further characterized by low to moderate sorptive capacity.

5. Diatomite: Class of opaline silica skeletal remains of aquatic species which includes diatomaceous earth, tripolite, kieselguhr, and fossil flour, characterized by high (85-93%) silica content, and having high absorptive and low adsorptive capacity.

6. Silica: Diverse origin materials characterized by very high (98-100%) silica content and high (75-100%) sorptive capacity (synthetic), or low sorptive capacity, such as sand.

7. Botanicals: Any material of plant origin capable of being processed into particles of the desired size, including nut shell flours, wood and cellulose flours, corncobs, and the like. *

8. Calcium Carbonate

Dust formulations are finely divided solid compositions of active ingredient in admixture with a solid carrier. In most cases dust formulations have an average particle size of less than about 50 microns, typically 5 to 40 microns, an active ingredient content of 1 to 30 percent by weight, and from 70 to 99 percent by weight of one or more of the solid diluents or carriers described above. Since dust formulations are generally applied as such or mixed with other' solids for application, they generally do not require a surface active agent or other adjuvants. The following exemplify typical dust formulations:

1% Dust % W/W

Active Ingredient 1.0 '

Finely Divided Silica 99.0

100.0 ¹

I

10% Dust	% W/W
Active Ingredient	10.0
Kaolin	90.0
	100.0
30% Dust
Active Ingredient	30.0
MontmorilIonite	30.0
Talc	40.0

100.0

Wettable powders are finely divided solid compositions which disperse readily in water or other liquid vehicles. The wettable powder may be applied as a dry dust or as a dispersion in water or other liquid. Thus, wettable powders are essentially a dust or powder formulation containing a surface active agent in addition to the active ingredient and solid carrier normally employed in dusts.

A wettable powder may thus typically contain from 1 to 95 percent by weight active ingredient, from 1 to 15 percent surface active agent, and from 4 to 98 percent by weight of one or more of the inert solid or dry carriers or diluents described above.

Suitable surface active agents may be selected from the following:

1. Salts or esters of sulfated or sulfonated fatty acids.

2. Salts or esters of ethylene oxide condensates of sulfated or sulfonated fatty acids.

3. Salts or amine derivatives of various resin and fatty acids including, but not restricted to, palmitic and myristic acids, tall oils, and taurine.

4. Salts of alkylarylsulfonates including alkylnaphthalenesulfonates and dialkylnaphthalenesulfonates.

5. Ethylene oxide condensates of mixed fatty and resin acids.

AP 0 0 0 0 5 A

-406. Ethylene oxide condensates of linear or branched chain glycols, secondary alcohols, or alkylaryl alcohols.

7. Mixed ethylene oxide and propylene oxide condensates of linear and branched chain glycols.

8. Salts of sulfonated naphthalene-formaldehyde condensates. *

9. Salts of carboxylated poly-electrolytes.

10. Salts of polymerized alkylnaphthalenesulfonic acids. i

11. Salts of lignin sulfonates.

12. Fatty alcohol polyglycol ethers.

13. Materials of classes 1, 2, 5, 6, 7 above when sorbed onto a sorptive, water compatible carrier.

, 14. Inorganic salts such as tripolyphosphate and hexametaphosphate.

15. Salts and esters of orthophosphoric acid.

16. Fatty acid esters of sorbitan. ,

17. Ethylene oxide condensates with fatty acid esters of sorbitan. '

18. Alkylated alkene mono- and polyhydrid alcohols.

19. Sulfonated castor oil. ,

20. Ethylene oxide condensate with lanolin.

21. Coconut alkanolaroides.

I

22. Sulfated sperm oil. ¹

23. Salts of linear alkyl sulfonates.

24. Tall oil ethoxylates.

The following are typical wettable powder^:

1% Powder % W/W

Active	Ingredient	1.0*
Sodium	lignosulfonate	7.5
Sodium	laurylsulfate	1.5
Talc		96.0
Total		100.01 ’j

-415% Powder

	Active Ingredient	5.0
	Sodium lignosulfonate	1.5
	Sodium alkylnaphthylene	1.5
5	sulfonate
	Attaclay	--5¾ t-Q
	Total	100.0
10	25% Powder Active Ingredient	25.0
	Sodium lignosulfonate	1.5
	Sodium laurylsulfate	1.5
	MontmorilIonite	72.0
	Total	100.0
15	90% Powder Active Ingredient ----	90.0
	Sodium dibutylnaphthalene- sulfonate ?	0.5
20	Sodium lignosulfonate	3.5
	Kaolin clay	6.0
	Total	100.0

Granules are solid or dry compositions of active ingredient deposited on or in a large particle.

Granules usually have an average particle size in the range of 150 to 5000 microns, typically 425 to 850 microns. Granular formulations generally contain from 1 to 50 percent by weight of active ingredient, from 1 to 15 percent by weight of one or more of the surface active agents described above, and from 50 to 98 percent by weight of one or more of the inert solid or dry _%carriers of diluents described above.

Granular formulation^ may be of several types. Impregnated granules are those in which the active ingredient is applied,'normally as a solution, to large

-42particles of an absorbent diluent or carrier such as attapulgite or kaolin clay, corncobs or expanded mica. Surface coated granules are granules produced by adhering an active ingredient in finely divided form on the surface of a generally non-absorbent particle or by %

applying a solution of active ingredient to the surface » of such a carrier. The carrier or core may be water soluble, such as prilled fertilizer or urea, or insoluble, such as sand, marble chips, corncobs, or coarse talc, as described above. Particularly useful are granules wherein a wettable powder is adhered as a surface coating to a sand or other insoluble particle, so that the wettable powder may be dispersed on contact of the granule with moisture. Granules may also be produced by agglomeration of dusts or powders, by compact , tion, by extrusion through a die, or by use of a granulation disk. ⁴

The following are typical granular formulations:

1% Granule % W/W

Active Ingredient 1.0

Attapulgite 99.0 ·

Total 100.0

5% Granule ^{1 :}

Active Ingredient 5.0 ¹

Attapulgite 95.0

Total 100.0 ^!

The granules above may be prepared by dissolving the active ingredient in a volatile solvent such as methylene chloride, coating large particles of attapulgite clay with the solution, then allowing the solvent to .evaporate.

As indicated above, granules may also be ^dhered to a nonabsorbent core material. The following are typical formulations:

5% Sand-Core Granule		% w/w
75% Powder Base		6.64
Active compound	75.0
Sodium alkylnaphthalene-
sulfonate	1.0
Sodium lignosulfonate	4.0
Barden clay	20.0	1
Dilute Polyvinylacetate		1.79
Silica (425-850)		91.61-
Total		100.00
47.5% Sand-Core Granule		% w/w
95% Powder Base		50.0
Active compound	95.0
Sodium alkylnaphthalene-		-
sulfonate	1.0
Sodium lignosulfonate	4.0
Dilute Polyvinylacetate		2.0,
adherent		4
Silica (425-850)		48.00
Total		100.00

AP 0 0 0 0 5 4

The foregoing sand-core granules may be prepared by incorporating the active' compound into the base, then adhering the base to sand, utilizing an adhesive such as polyvinylacetate to assure adhesion.

LIQUID AND SEMI-LIQUID FORMULATIONS

Liquid formulations are those which contain the active ingredient dissolved or dispersed in one or more inert liquid carriers or diluents, containing from 0.01 to about 95% active ingredient. Carriers suitable for use in liquid formulations may be selected from the following:

1. Water.

2. Aliphatic petroleum solvents including kerosene, light refined mineral oils, and diesel^oils.

i

-4410

3. Aromatic petroleum solvents including coal tar fractions yielding xylene, toluene, and benzene; light, medium, and heavy aromatic naphthas; and alkylated mixed naphthenics.

4. Alcohols such as ethanol and isopropyl alcohol.

5. Alkyl ethers of glycols. ,

6. Esters including dibutyl phthalate, di-2-ethylhexyl phthalate, and ethyl acetate.

7. Ketones including cyclohexanone, methyl isobutyl ketone, acetone, diacetone, and isophorone.

8. Chlorinated hydrocarbons including ethylene dichloride, methylene chloride, chlorobenzene, chlorinated toluene, and chlorinated xylene.

9. Vegetable oils including cottonseed, soybean, pine, sesame, and palm oils.

10. Aqueous solutions of natural origin such as liquors obtained in processing natural sugar products, and fermentation broths. '*

Solutions are liquid compositions containing from about 0.01 to 95 percent by weight active ingredient and from 1 to 99.99 percent by weight of one or more of the inert liquid diluents or' carriers described above.

These may be applied as such or further diluted for application.

Suspensions or dispersions (also sometimes called flowable formulations) are liquid formulations containing from 0.01 to 95 percent by weight active ingredient and from 1 to 99.99 percent by weight of an inert liquid diluent or carrier, in which the active ingredient is wholly or partially insoluble in the diluent or carrier at the concentration level employed. Suspension or , dispersion is frequently facilitated by incorporating from 1 to 30 percent by weight of one or more surface active agents described-above, alone or together with a i

-45thickener or suspending agent. Like solutions, dispersions may be used as such or further diluted with a liquid carrier for application.

The following illustrate suspensions suitable for use in the present invention:

25% Oil Suspension: % w/w ;

Active ingredient 25.0 polyoxyethylene sorbitol hexaoleate 5.0 v aliphatic hydrocarbon oil Total

70.0

100.0

1% Aqueous Suspension: % W/W

Active ingredient l.o

Polyacrylic acid thickener 0.3

Sodium alkylnaphthalenesulfonate 1.0

Sodium lignosulfonate 4.0

Polyvinyl alcohol suspending agent 1.0

Water 92.7

Total 100.0

20% Aqueous Suspension:

Active ingredient 20.0

Polyacrylic acid thickener 0.3

Sodium alkylnaphthalenesulfonate 1.0

Sodium lignosulfonate 4.0

Polyvinyl alcohol suspending agent 1.0

Water 73.7

Total 100.0

40% Aqueous Suspension:

Active ingredient

Polyacrylic acid thickener Dodecylphenol polyethylene glycol ether Disodium phosphate

40.0

0.3

0.5

1.0

-46Monosodium phosphate Polyvinyl alcohol Water

0.5

1.0

56.7

Total

100.0

Emulsifiable concentrates (EC’s) are homogeneous liquid compositions, containing the active ingredient dissolved in a liquid carrier. Commonly used liquid carriers include xylene, heavy aromatic naphthas, isophorone, and other nonvolatile or slightly volatile organic solvents. For application these concentrates are dispersed in water, or other liquid vehicle, forming an emulsion, and are normally applied as a spray to the area to be treated. The concentration of the essential active ingredient in EC's may vary according to the manner in which the composition is to be applied, but, l

in general, is in the range of 0.01 to 95 percent by weight of active ingredient. Also included in the composition are from 1 to 30 percent by weight surface active agent and from 4 to 97.99 percent of one or more of the inert liquid carriers described above. The following are typical EC compositions:

1% Emulsifiable Concentrate % W/W

Active Ingredient 1.0

Anionic calcium dodecylbenzenesulfonate 4.2

Nonionic polyethoxylated nonylphenol (Mol. Wt. 450-500) 0.4 ’

Nonionic polyethoxylated nonylphenol (Mol. Wt. 1400-1600) 1.1

Nonionic paste of 100% poly- ' alkylene glycol ether 0.4 , Xylene 92.9 ·

Total

100.0

-475% Emulsifiable Concentrate

Active Ingredient

Anionic calcium dodecylbenzenesulfonate

Nonionic polyethoxylated nonylphenol (Mol. Wt. 450-500)

Nonionic polyethoxylated nonylphenol (Mol. Wt. 1450-1600)

Nonionic paste of 100% poly10 alkylene glycol ether

Xylene

Total

10% Emulsifiable Concentrate 15 Active Ingredient

Blend of alkylnaphthalenesulfonate and polyoxyethylene ethers

Xylene

Total

50% Emulsifiable Concentrate

Active Ingredient

Blend of alkylnaphthalenesulfonate and polyoxyethylene ethers

Epoxidized soybean oil

Xylene

Total

75% Emulsifiable Concentrate 3Q Active Ingredient

Blend of alkylnaphthalenesulfonate and polyoxyethylene ethers

Xylene

Total

5.0

4.2

0.4

1.1

0.4

88,9

100.0 % W/W

10.0

4.0'

86.0

100.0

50.0

6.0

1.0

43.0

100.0

75.0

4.0

21.0

100.0

-48Other useful formulations include simple solutions of the active ingredient in a relatively non-volatile solvent such as corn oil, kerosene, propylene glycol, or other organic solvents. This type of formulation is particularly useful for ultra low volume application.

The concentration of the active ingredient in use dilution is normally in the range of about 2% to about 0.1%. Many variations of spraying, dusting, and controlled or slow release compositions in the a^t may be used by substituting or adding a compound of this invention into compositions known or apparent to the art.

These compositions may be formulated and applied with other suitable active ingredients, including nematicides, insecticides, acaricides, fungicides, plant regulators, herbicides, fertilizers, etc.

In applying the foregoing chemicals, an effective insect controlling amount of active ingredient must be applied, sometimes referred to herein as an insecticidal amount. While the application rate will vary widely depending on the choice of compound, the formulation and mode of application, the plant species being protected and the planting density,· a suitable use rate may be in the range of 0.10 to 0.50 kg per hectare, preferably 0.25 to about 1.5 kg/hectare.

The compounds of this invention may be applied by incorporating or applying a formulation thereof to a food source for the insects to be controlled, i.e. the locus where control is required, including application to the above ground portions of plants on which the insects feed, to the soil in which plants are or are about to be planted in order to provide control of soilborne insects, or in a bait-type formulation¹for application to'surfaces on which insects normally do not feed. When applying the compounds to the soil, the compounds may be broaddast broadly over the planted area

-49or the area to be planted or by limiting the application to a small area or band in the root zone where plants are or are to be planted. When either method of soil application is used, sufficient compound must be applied to provide an insect controlling concentration of the l

compound in the soil in the root zone. For the present a suitable concentration is about 0.2 to about 50 parts by weight of compound per million parts of s<jil.

The insecticidal activity of the pyrethroid-like compound of this invention was evaluated as follows: Foliar Evaluation

The compound was tested by foliar application at various concentrations in aqueous solutions containing 10% acetone and 0.25% octyl phenoxypolyethoxy ethanol.

Th,e evaluation utilized Mexican bean beetle (Epilachna varivestis), southern armyworm fSpodoptera eridania), pea aphid (Acyrthosiphon pisum), cabbage loop^r (Trichoplusia ni). beet armyworm (Spodoptera Jexigua). and twospotted spider mite (Tetranvchus urticae).

For all insects except pea aphid, pinto 'bean (Phaseolus vulgaris) plants were placed on a revolving turntable in a hood, and the test solutions were applied with a sprayer. The test solutions were applied to the upper and lower surfaces of the plant leaves to runoff.

The plants were then allowed to dry and were severed at the base of the stem before being placed in cups. Ten individuals of the appropriate insect species were placed in each cup and the cup covered. Mortality was read 48 hours later.

₃q Fava bean was substituted for pinto bean in the case of pea aphid, and the treated, potted plants were placed • in cups infested with ten individuals and covered. Mortality was read 48 hours later. '

Acaricidal tests were performed using the following ₃₅ procedure: Leaves infesied with adult twospqtted spider

AP 0 0 0 0 5 A

-50mites (Tetranychus urticae) were removed from culture plants and cut into segments containing 50-75 female mites. Each segment was placed on the upper leaf surface of a whole pinto bean plant. After the mites had migrated to the under surfaces of the leaves, ithe leaf segments used to infest were removed, and each plant was sprayed with test chemical as described above. After the plants had dried, the entire plant and po£ were placed in metal trays in a hood, a supply of water in the tray keeping the plants turgid. After 48 hours the living and dead mites were counted, and percent mortality was calculated.

The results of these tests are shown in Table 4.

Soil Evaluation • A stock solution of the test compound was prepared by dissolving 9.6 mg in 10 mL of acetone and'diluting with 90 mL of acetone/watfer (1:9). The addition of 5 mL of this stock solution to* 30 grams of air-dried, clay loam soil in a three ounce plastic cup provided a concentration of 16 ppm of the test compound in the soil. Serial dilution of the stock solution was used to provide concentrations of the test compound in soil of 8,

4, 2, 1, 0.5, and 0.25 ppm. In all cases 5 mL of a solution having the required concentration was added to 30 grams of soil. The treated soil was allov/ed to stand uncovered in a hood for 0.5 hour to evaporate the acetone. Before infesting the soil with southern corn rootworm larvae (Diabrotica undecimpunctata howardi Barber) the soil was mixed thoroughly, and two threeday-old corn sprouts were'planted in it. Ter early third-stage (9-10 days old) southern corn rootworm *larvae were placed in the^cup which was covered with a plastic bag. After storage at 74-78°F for 48 hours, the mortality of the larvae, was determined by removing the

-51cup from the plastic bag, removing the cover, and placing the cup in a modified Berlese polyethylene funnel fitted with an 18-mesh screen. The funnels were placed over containers of an aqueous detergent solution.

Incandescent lights (100 watts) were placed 36 cm above the soil samples. The heat from these lights slowly dried the soil causing larvae that had not been affected by the test compound to emerge from the soil and drop into the detergent solution. The percent mortality was ₀ determined in this manner for each concentration.

Results of these tests are reported in Table 5.

Fish Toxicity i

The toxicity towards fish was determined in a 48 hour static bioassay using the bluegill sunfish (Lepomis maCrochirus). Three fish ranging in size frota 1 to 2 inches were placed in a 0.95 liter jar containing the specified concentration of the compound. Two,¹ replicates

I were used for each concentration. After 48 hburs the percent kill was determined. Concentrations of chemiθ cals used were 6.3 ppm, 3.1 ppm, and occasionally 1.7 ppm. Compound 16, the compound of Example 1 and a preferred compound of this invention, exhibited 83% kill at 6.3 ppm. Another preferred compound, Compound 24, killed only 50% of the fish at the same concentration.

₅ By way of comparison, cypermethrin, a conventional pyrethroid insecticide used widely for crop protection, displays 100% kill at a concentration of 0.01,ppm.

The remarkably low toxicity towards fish of the pyrethroid-like compounds is certainly unexpected, and this factor, in combination with the demonstrated insecticidal activity, should make them appropriate compounds for control of insect infestations in aquatic . . · * environments, such as rice paddies.

AP 0 0 0 0 5 A

I

-52TABLE 1 - TABLE OF ETHERS, THIOETHERS, AND BUTANE DERIVATIVES

Ar-CH-CH₂-Z-CH₂-Ar'

Cmpd

No .	Ar	Z	Ar' :
1	phenyl	0	2-methyl[1,1'-biphenyl]- 3-yl
2	phenyl	0	3-phenoxyphenyl
3	phenyl	0	4 - fluoro - 3 -phenoxyphenyl
4	4 - fluorophenyl	0	2-methyl[1,1'-biphenyl]- 3-yl
5	4 - fluorophenyl	0	3 -phenoxyphenyl
6	4 - fluorophenyl	0	4-fluoro-3-phenoxyphenyl
k 7	2-chlorophenyl	0	2-methyl[1,1’ --biphenyl] -3-yl
8	2-chlorophenyl	0	3-phenoxyphenyl
9	2-chlorophenyl	0	4 - fluoro-3 -phenoxyphenyl
10	3-chlorophenyl	0	2-methyl[l,l'rbiphenyl]-3-yl
11	3-chlorophenyl	0	3-phenoxyphenyl
12	3-chlorophenyl	0	4 - fluoro - 3 -phenoxyphe ny1
13	4-chlorophenyl	0	2-methyl[1,1'-biphenyl]-3-yl
14	4 - chlorophenyl	0	3 -phenoxyphenyl
15	4-chlorophenyl	0	3 -phenoxyphenyl (Stereoisomer B)a
16	4-chlorophenyl	0	1 4-fluoro-3-phenoxyphenyl
17	4-chlorophenyl	0	4 - fluoro - 3 -phenoxyphenyl (Stereoisomer A)b
18	4-chlorophenyl	0	4 - fluoro- 3 -phenoxyphenyl (Srereoispmer B)c
19 .	4 - chlorophenyl	s	2-methyl[1,1'- biphenyl]-3-yl
20	4-chlorophenyl	S	3-phenoxyphenyl
21	4-chlorophenyl	S	4-fluoro-3-phenoxyphenyl
22	4-bromophenyl	0	2-methyl[1,1‘rbiphenyl]-3-yl
23	4-broraophenyl ’	0	3 -phenoxyphenyl

BAD

-53Table 1 (continued)

Cmpd No .	Ar	Z	Ar'
24	4-bromophenyl	0	4-fluoro-3-phenoxyphenyl
25	4-methylphenyl	0	2-methyl[1,1'-biphenyl]- 3-yl
26	4-methylphenyl	0	3-phenoxyphenyl
27	4-methylphenyl	0	4 - fluoro - 3 -phenoxyphenyl
28	3-ethylphenyl	0	2-methyl[1,11-biphenyl]- 3-yl
29	3-ethylphenyl	0	3-phenoxyphenyl
30	3-ethylphenyl	0	4-fluoro-3-phenoxyphenyl
31	4-ethylphenyl	0	2-methyl[1,1'-biphenyl]- 3-y1
32	4-ethylphenyl	0	3-phenoxyphenyl
33	4-ethylphenyl	0	4-fluoro-3-phenoxyphenyl
34	4-i-butylphenyl	0	2-methyl[l,1'-biphenyl]-3-yl
35	4-£-butylpheny1	0	3 -phenoxyphenyl
36	4-t-butylphenyl	0	4- fluoro- 3-phenoxyphenyl
37	4-trifluoromethylphenyl	0	2-methyl[1,1'-biphenyl]-3-yl
38	4-trifluoromethylphenyl	0	3-phenoxyphenyl
39	4-trifluoromethylphenyl	0	4 - fluoro - 3 -phenoxyphenyl
40	4- me thoxyphe ny1	0	2 -me thyl [ 1,1,' -biphenyl j -3-yl
41	4-methoxyphenyl	0	3-phenoxyphenyl
42	4-methoxyphenyl	0	4 - fluoro - 3 - phenoxyphenyl
43	4 -e thoxypheny1	0	2-methyl[1,1'-biphenyl]-3-yl
44	4-ethoxyphenyl	0	3 -phenoxyphenyl
45	4-ethoxyphenyl	0	4-fluoro-3-phenoxyphenyl
46	4-difluoromethoxyphenyl	0	2-me thyl[1,1'-biphenyl]-3-yl
47	4-difluoromethoxyphenyl	0	3 -phenoxyphenyl
48	4-difluoromethoxyphenyl	0	4-fluoro-3-phenoxyphenyl
49	4- trifluoromethoxypher.yl	0	2-me thyl[1,1’-biphenyl[-3-yl
50	4-trifluoromethoxyphenyl	0	3-phenoxyphenyl
51	4 -trifluoromethoxyphenyl	0	4-fluoro-3-phenoxyphenyl
52	4-(2-fluoroe thoxy ) phenyl	0	2-methyl[1,1'-biphenyl J-3-yl
53	4- (2-fluoroe thoxy )phJnyl	0	3 -phenoxyphenyl
54.	4-(2- fluoroethoxy)phdnyl	0	4-fluoro- 3 -phenoxyphenyl
55	4-trifluororae thylthiophenyl	0	2-methyl[1,1”-biphenyl]-3-yl
56	4-tri fluoromethyl thiophenyl	0	3-phenoxyphenyl

AP 0 0 0 0 5 4

BAD ORIGINAL

-54Cmpd

No .

Table 1 (continued)

Ar

Z

Ar'

57	4 -trifluoromethylthiophenyl	0	4- fluoro-3-phenoxyphenyl
58	4-trifluoromethylsulfinylphenyl	0	2-methyl[1,1'-biphenyl]- 3-y1
59	4-trifluoromethylsulfinylphenyl	0	3 -phenoxyphenyl
60	4-trifluoromethylsulfinylphenyl	0	4-fluoro - 3 -phenoxyphenyl
61	4 -trifluoromethylsulfonylphenyl	0	2-methyl[1,1'-biphenyl)- 3-yl
62	4-trifluoromethylsulfonylphenyl	0	3-phenoxyphenyl
63	4-trifluoromethylsulfonylphenyl	0	4 - fluoro - 3 -phenoxyphenyl
64	1,3-benzodioxol- 5-yl	0	2-methyl[1,1'-biphenyl]- 3-yl
65	1,3-benzodioxol-5-yl	0	3-phenoxyphenyl
66	1,3-benzodioxol- 5-yl	0	4-fluoro -3-phenoxyphenyl
67	2,2-difluoro-1,3-benzo - dioxol-5-yl	0	2-methyl[1,1'-biphenyl]- 3-yl
68	2,2-difluoro-1,3-benzo- I dioxol-5-yl	0	3-phenoxyphenyl
69	2.2-difluoro-l,3-benzo- dioxol-5-yl	0	4-fluoro-3-phenoxyphenyl
70	3 -chlo ro-4 - n ethoxyphenyl	0	2-methyl[ 1,1 ''-biphenyl] -3-yl
71	2,3-dihydro-2,2-dimethyl- benzofuran-5-yl	0	2-methyl[1,1t-bipheny1]-3-yl
72	2,3 - dihydro - 2,2-dimethylbenzofuran-5-yl	0	3 -phenoxyphenyl
73	2,3-dihydro-2,2-diraethyl- benzofuran-5-yl	0	4-fluoro-3-phenoxyphenyl
74	2,2,3,3-tetrafluoro- benzofuran-5-yl	0	2-methyl[1,1*-biphenyl]-3-yl
75	2,2,3 ,tetrafluoro- benzofuran-5-yl	0	3-phenoxyphenyl
76	2,2,3,3-tetrafluord-— . benzofuran-5-yl	0	4- fluoro - 3-phenoxyphenyl
77	2-thienyl · J	0	2-methyl[l,l| -biphenyl)-3-yl
78	2 - thienyl	0	3 -phenoxyphenyl
79	2-thienyl	0	4 - fluoro - 3 - pjtenoxypheny 1
80	4-chlorophenyl	0	6 -phenoxy-2-pyridyl

Cmpd No .	Table 1 (continued)
Ar	• » Z Ar'
81	4 - e thoxyphenyl	0 6-phenoxy-2-pyridyl
82	2-chlorophenyl	CH2 3-phenoxyphenyl
83	2-chlorophenyl	CH2 4-fluoro-3-phenoxyphenyl
84	3 -chlorophenyl	CH2 2-methyl(1,1f-biphenyl]-3-yl
85	3-chlorophenyl	CH2 3-phenoxyphenyl
86	3 - chlorophenyl	CH2 4-fluoro-3-phenoxyphenyl
87	4-chlorophenyl	CH2 2-methyl(1,1'-biphenyl]-3-y1
88	4-chlorophenyl	CH2 3-phenoxyphenyl
89	4-chlorophenyl	CH2 4-fluoro-3-phenoxyphenyl
90	4 - chlorophenyl	CH2 6-phenoxy-2-pyridyl
91	4-bromophenyl	CH2 2-methyl[1,1'-biphenyl]-3-yl
92	4-bromophenyl	CH2 3-phenoxyphenyl
93	4-bromophenyl	CH2 4-fluoro-3-phenoxyphenyl
94	4-methylphenyl	CH2 2-methyl[1,1'-biphenyl]-3-yl
95	4 - me thylpheny1	CH2 3-phenoxyphenyl
96	4-methylphenyl	CH2 4-fluoro-3-p1ienoxyphenyl
97	4-trifluoromethylphenyl	CH2 2-methyl (1,1'-biphenyl]-3-yl
98	4 -trifluoromethylphenyl	CH2 3-phenoxyphenyl
99	4 -tri fluorome thylpheny1	CH£ 4-fluoro-3-phenoxyphenyl
100	4-methoxyphenyl	CH2 2-methyl[1,1'-biphenyl]-3-yl
101	4-methoxyphenyl	CH2 3-phenoxyphenyl
102	4-methoxyphenyl	CH2 4-fluoro-3-phenoxyphenyl
103	4 - e thoxyphenyl	CH2 2-methyl]1,1'-biphenyl]-3-yl
104	4 - e thoxyphenyl	CH2 3-phenoxyphenyl
105	4 -e thoxyphenyl	CH2 4-fluoro-3-phenoxyphenyl
106	4-difluoromethoxyphenyl	CH2 2-methyl{1,P-biphenyl]-3-yl
107.	4 - di fluoromethoxyphenyl	CH2 3-phenoxyphenyl
108	4-difluoromethoxyphenyl	CH2 4-fluoro-3-£|ienoxyphenyl
109	4-trifluoromethoxyphenyl	CH2 2-methyl[1,1'-biphenyl]-3-yl
110	4 -trifluoromethoxyphenyl	CH2 3-phenoxyphenyl
111	4 -trifluoromethoxyphenyl	CH2 4-fluoro-3-phenoxyphenyl
112	4-(2-fluoroethoxy)phenyl	CH2 2-methyl[1,1'-biphenyl]-3-yl
113	4-(2-fluoroethoxy)phenyl	CH2 3-phenoxyphenyl

AP 0 0 0 0 5 4

BAD ORIGINAL

-56Table

Cmpd
No .	Ar
114	4-(2-fluoroethoxy)phenyl
115	1,3-benzodioxol- 5-yl
116	1,3-benzodioxol-5-yl
117	1,3-benzodioxol-5-yl
118	2,2 - di fluoro -1,3-benzo - dioxol-5-yl
119	2 , 2-difluoro -1,3-benzo- dioxo1- 5-yl
120	2,2-difluoro-1,3-benzodioxol - 5 -yl
121	4 - trifluoromethylthiophenyl
122*	4-trifluoromethylthiophenyl
123	4-trifluoromethylthiophenyl
124	2,3 -dihydro - 2,2 -dime thyl- benzofuran-5-yl
125	2,3 -dihydro- 2,2 -dime thyl- benzofuran-5-yl
126	2.3 - dihydro - 2,2 - dimethyl benzofuran-5-yl
127	2,2,3,3-te trafluoro- benzofuran-5-yl
128	2,2,3,3-tetrafluoro- benzofuran-5-yl
129	2,2,3,3-tetraf luoro-’ benzofuran-5-yl
130	2-thienyl
131 ·	2 -1 h i e ny1
132	4 - ethoxyphenyl
a.	[o]g5-(-)26.20° in CHC13
b.	[a]g5-(+)22.19° in CHC13
c.	{a]g5-(-)20.64° in CHC13

(continued)

Ar ·

CH2 4-fluoro-3-phenoxypheny1 CH2 2-methyl[1,1'-biphenyl]-3-yl CH2 3-phenoxypheny1

CH2 4-fluoro-3-phenoxypheny1 CH2 2-methyl[1,1'-biphenyl]-3-yl

CH2 3-phenoxyohenyl

CH2 4-fluoro-3-phenoxypheny1

CH2 2-methyl[1,1'-biphenyl]-3-yl CH2 3-phenoxypheny1 CH2 ,4-fluoro-3-phenoxyphenyl CH2 2-methyl[l,l'-biphenyl]-3-yl •'

CH2 3 -phenoxypheny1

CH2 4-fluoro-3-phenoxyphenyl

CH2 2-methyl (1,1'-biphenyl]-3-yl

CH2 3-phenoxyphenyl

CH2 4-fluoro-3-phenoxyphenyl

CH2 3-phenoxyphenyl

CH2 4-fluoro-3-phenoxypheny1

CH2 6-phenoxy-2-pyridyl

	TABLE 2 - INSECTICIDAL AND 1-CYCLOPROPYL-1,3	ACARICIDAL 1,4-DlARYL- -BUTADIENE DERIVATIVES
	Y Ar-C-CH-CH-	CH-Ar'
Cmpd No.	Ar	Ar'
Al	3-chlorophenyl	2-methyl[1,1'-biphenyl) -3-yl
A2	3 - chlorophenyl	3 -phenoxyphenyl
A3	3 - chlorophenyl	4 - fluoro - 3 -phenoxyphenyl
A4	4 - chlorophenyl	2-methyl[1,1'-biphenyl]-3-yl
A5	4-chlorophenyl	3 -phenoxyphenyl
A6	4-chlorophenyl	4-fluoro-3-phenoxyphenyl
A7	4 - chlorophenyl	6 -phenoxy-2 -pyridyl
A8	4-methylpheny1	2-methyl[1,1*-biphenyl J-3-yl
A9	4-methylphenyl	3-phenoxyphenyl
A10	4-methylpheny1	4- fluoro- 3-phenoxyphenyl
All	4-trifluoromethylphenyl	2-methyl[1,1'-biphenyl]-3-yl
A12	4-trifluoromethylphenyl	3 -phenoxyphenyl
A13	4 -trifluoromethylphenyl	4-fluoro-3-phenoxyphenyl
A14	4-ethoxyphenyl	2-methyl[l,1'-biphenyl]-3-yl
A15	4-ethoxyphenyl	3 -phenoxyphenyl
A16	4-ethoxyphenyl	4 - fluoro- 3 -phenoxyphenyl
A17	4-trifluoromethoxyphenyl	2-methyl[1,1'-biphenyl]- 3-yl
A18	4-trifluoromethoxyphenyl	3 -phenoxyphenyl
A19	4-trifluoromethoxyphenyl	4 - fluoro- 3 -phenoxyphenyl
A20	1,3-benzodioxol-5-yl	2-methyl[l,1'-biphenyl]-3-yl
A21	1,3-benzodioxol-5-yl	3 -phenoxyphenyl
A22	1,3-benzodioxol-5-yl	4 - fluoro - 3 -phenoxyphenyl
A23	2,3-dihydro-2,2-dimethyl- benzofuran-5-yl	2-methyl[1,1'-biphenyl]-3-yl r
A24	2,3-dihydro - 2,2-dimethyl- benzofuran- 5 -'yl	3-phenoxyphenyl

AP 0 0 0 0 5 4

BAD ORIGINAL

I

	Table 2 -	(continued)
CmDd No .	Ar	Ar’
A25	2,3-dihydro-2,2 - dimethyl- benzofuran-5-yl	4- fluoro-3-pher.oxyphenyl
A26	2-thienyl '	2-methyl[l,1-biphenyl]-3-yl
A27	2 - thienyl	3 -phenoxyphenyl
A28	2-thienyl	4- fluoro - 3 -phenoxyphenyl

i

-59TABLE 3 - INSECTICIDAL AND ACARICIDAL 1,4-DlARYLCYCLOPROPYL-1-BUTENE DERIVATIVES

V

Ar-C-CH-CH₂-CH₂-Ar'

Cmpd No	Ar	Ar'
Bl	phenyl	4 -f1uoro- 3-phepoxyphenyl
B2	4 - fluorophenyl	3-phenoxyphenyl
B3	4-fluorophenyl	4-fluoro-3-phenoxyphenyl
B4	2-chlorophenyl	2-methyl[1,1'-biphenyl}- 3 -yl
B5	2-chlorophenyl	3 -phenoxyphenyl
B6	2-chlorophenyl	4- fluoro - 3 -phenoxyphenyl
B7	4-chlorophenyl	3-phenoxyphenyl
-B8	4-chlorophenyl	4 - fluoro - 3 - phienoxypheny 1
B9	4-bromophenyl	3-phenoxyphenyl
BIO	4-ethylphenyl	2-methyl[1,1'-biphenyl J-3-yl
Bll	4-ethylphenyl .	4- fluoro-3-phenoxyphenyl
*B12	4-methoxyphenyl	3-phenoxyphenyl
**B13	4-methoxyphenyl	3 -phenoxyphenyl
B14	4 - difluorome thoxyphenyl	2-methyl[1,1'-biphenyl J -3-yl
B15	4-difluororaethoxyphenyl	3-phenoxyphenyl
B16	4-difluorome thoxyphenyl	4- fluoro - 3 -phenoxyphenyl
BI7	4-(2-fluoroethoxy)phenyl	3-phenoxyphenyl
B18	4- (2-fluoroethoxy)phenyl	4 - fluoro- 3 -phenoxypheny1
B19	4 - trifluoromethylthiophenyl	2-methyl[1,1'-biphenyl]- 3-yl
B20	4-trifluoromethylthiophenyl	3 -phenoxyphenyl
B21	4-trifluoromethylthiophenyl	4- fluoro -3-phenoxyphenyl
B22	2,2-difluoro-1,3-benzo- dioxol- 5-yl	2-methyl[1,1'-biphenyl J -3-yl
B23	2,2-difluoro-1,3-benzo- dioxol-5-yl	3-phenoxyphenyl.
B24	2,2-difluoro-1,3-benzo- dioxol-5-yl	4 - fluoro- 3-pheiftoxypheny1

BAD ORIGINAL

I

-60Table 3 (continued)

Cmpd No, _Ar

B25 2,2,3,3-tetrafluorobenzofuran-5-yl

B26 2,2,3,3-tetrafluorobenzofuran-5-yl

B27 2,2,3,3-tetrafluorobenzofuran-5-yl * Mixture of 57% Z isomer and 43% E analysis (area %) ** Mixture of 86% Z isomer and 14% E analysis (area %)

Ar'

2-me thyl[1,1'-biphenylj- 3-yl

-phenoxyphenyl

- fluoro - 3 - pherloxypheny 1 t* isomer by gas chromatographic isomer by gas chromatographic feAD

	TABLE 4	- FOLIAR	INSECTICIDAL	TEST	RESULTS
Cmpd No.	Rate iP-P.mL	BAW	MBB	% SAW	Kill TSM	CL	PA
1	500				9		0
	100	45	0			20
2	500			23			5
	100	95	95			55
3	500				20		25
	100	100	100			85
4	1000						15
	250		85			85
5	500						70
	250		100			95
6	1000						60
	250		100			100
10	1000		35		29	95	50
11	1000		100		55	100	100
12	1000		100		100	100	90
13	1000		100	100	100		100
	100	90				50
14 '	1000		100	100	90a		100
	100	100				95
15	1000		100			100	90

AP Ο Ο Ο Ο 5 4

Table 4 (continued)

Cmpd No.	Rate	% Kill
l&prcl	BAW	MBB	SAW	tsm	CL	PA
16	1000		100	100	100		100
	100	100				100
17	500				38		100
	100		75	95
	50	90				95
18	500				83		100
	100		100	100
	50	100				100
1*3	1000				11
	500		45
	250					100	20
20	500				12
	250		95			100	75
21	500				15
	250		100			100	90
22	1000	100	80		60		70
	500					95
23	1000	100	100		77		100
	500					100
24	1000	100	100		100		80
	500					100

-63Table 4 (continued)

Cmpd	Rate	% Kill
No.	lepM	BAW	MBB	SAW	TSM	CL	PA
25	1000		100		0		35
	500	100				100
26	1000		100		0		45
	500	100				100
27	1000		100		40		35
	500	100				100
34	500						25
	100	35	70		16	10
35	500				99a		90
	100	55	100			0
36	500				100		60
	100	55	100			45
37	1000		100		100	100	100
38	1000		100		100	100	100
39	1000		100		100	95	90
40	1000	100	100		40		80
	500					75
41	1000		100	100	0		100
	500	95 ·				85

AP 0 0 0 0 5 4

Table 4 (continued)

Cmpd No.	Rate (PPral	BAW	% Kill
MBB	SAW	TSM	CL	PA
42	1000		75	100	0		100
	500	100				100
43	500	100	100		0	100	0
44	500	100	100		0	100	60
45	1000				100
	500	100	100			100	90
46	1000		80		100	95	90
47	1000		70		100	100	100
48	1000		95		100	100	100
49	1000		100		100	100	100
50	1000		100		100	100	100
51	1000		100		100	100	100
52	1000						0
	250		75			85

1000 55

250 . 100

100

-65Table 4 (continued)

Cmpd No.	Rate	% Kill	PA
	BAW	MBB	SAW TSM	CL
54	1000					65
	250		90		100
55	1000		100	100	100	75
56	1000		100	100	100	95
57	1000		100	100	100	90
58	1000		75	100	100	0
59 *	1000		100	100	100	90
60	1000		100	100	100	80
61	1000		60	94	100	0
62	1000		100	100	80	80
63	1000		100	100	100	95
64	500			23
	250		85		100	80
65	500			1
	250		90		100	70
66	250		100	11	100	65
70	500	100	80	1	40	0
77	500	•		14		0
	100	0	0		0

AP 0 0 0 0 5 4

	Table 4 (continued)
Cmpd	Rate			% Kill
No.	(PPm).	BAW	MBB	SAW TSM	CL	PA
78	500			11		0
	100	20	0		0
79	500			10		0
	100	45	15		0
80	1000		95	96	100	100
84	1000		95	21	90	65
85	1000		100	14	100	95
8 6	1000		80	92	100	85
8?	1000		100	97	100	90
88	1000		100	100	100	80
89	1000		100	100	100	100
94	1000		100	63	100	35
95	1000		100	50	100	55
96	1000		100	100	100	40
97	1000		100	99	100	100
98	1000		100	100	100	100
99	1000		100	100	100	100

Cmpd No.	Rate lEpml	Table BAW	4 (continued) %	Kill
MBB	SAW	TSM	CL	PA
103	1000		95		100	85	95
104	1000		100		89	100	60
105	1000		100		100	100	95
109	1000		100		100	100	80
110	1000		100		100	100	100
111	1000		100		100	100	100
A4	1000		63a		0	5	0
A6	1000		68a		0	25	0
A8	1000		0		0	0	0
A9	1000		0		0	0	0
A10	1000		0		0	30	0
All	1000		68a		0	88a	0
A12	1000		78a		0	68a	0
A13	1000		95a		0	100a	0
A15 «	1000		55		0	60	0
B7	1000	•	90 .		0		0

500

-68Table 4 (continued)

Cmpd Ho . B3	Rate	% Kill	PA 100
Ippml 1000 500	BAW 95	MBB 100	SAW TSM 0	CL 100
B9	1000		65	0		0
	500	100			35
B12	500	100	100	0	20	30
B13	1000		65	0	0	0

a. Average of two tests

BAW = beet armyworm

MBB = Mexican bean beetle SAW = southern armyworm TSM = twospotted spider mite

CL = cabbage looper PA = pea aphid

-69TABLE 5 - SOIL INSECTICIDAL TEST RESULTS

Cmpd.	Rate
No.	(tnm)
13	Ϊ6
14	2
16	16
22	16
26	16
27	16
40	16
41	16
42	16
48	15
57	15
80	15
85	15
88	*5
89	15
94	15
95	15
96	15
99	15
103	15
105	15
110	15
B7	15
B8	15
B9	15

Initial % Kill SCR

75^a

100

100

Ab

A

A

A

A

A

A

A .a. = Average of two tests.

b. = A = active = >75% kill f

SCR = southern corn rootworm

-70- («··,

Claims (7)

1. Claims: ;

   1. A compound characterized by the formula

   Y

   Ar-CH-CH₂-Z-CH2-Ar· in which Ar is a substituted or unsubstituted phenyl or thienyl; Z is oxygen, sulfur, or methylene; and Ar' is a substituted or unsubstituted phenoxyphenyl, 2-methyl[ 1, 1'-biphenyl]-3-yl, or 6-phenoxy-2-pyridyl.
2. 2. a compound of claim 1 characterized in that Ar' is 3-phenoxyphenyl, 4-fluoro-3-phenoxyphenyl, 2-methyl[ 1,1'-biphenyl]-3-yl, or 6-phenoxy-2-pyridyl.
3. 3. A compound of claim 2 characterized in that Ar is selected from phenyl/ (C^_g)alkylphenyl, halophenyl, (C^_4)haloalkylphenyl, (C^_₄)alkoxyphenyl, ) haloalkoxyphenyl, and 1,3-benzodioxol-5-yl.
4. 4. A compound of claim 3 characterized in that Ar' is 3-phenoxyphenyl; Z is oxygen; and Ar is selected from phenyl, 4-fluorophenyl, 3-chlorophenyl, 4-chlorophenyl,

   4-bromophenyl, 4-raethylphenyl, 4-t-butylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl, 4-ethoxyphenyl, 4(2-fluoroethoxy)phenyl, 4-difluoromethoxyphenyl, 4-trifluoromethoxyphenyl and 1,3-benzodioxol-5-yl.

   5. A compound of claim 4 characterized in that Ar is 4-chlorophenyl for which [ 1» in chloroform is negative 6. A compound of claim 4 characterized in that Ar is 4-trifluoromethylphenyl. 7. A compound of claim 4 characterized in that Ar is 4-trifluoromethoxyphenyl. 8. A compound of claim 3 characterized in that Ar is 4-fluoro-3-phenoxyphenyl; Z is oxygen; and Ar is

   selected from 4-fluordphenyl, 3-chlorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-methylphenyl, 4-t-butylphenyl,

   -714-tri f luorometjiylpheryl, 4-methoxyphenyl, 4-ethoxyphenyl, 4 - (2 - fluoroethoxy)phenyl, 4-diflucrcmethcxyphenyl, 4--.r: fiucrcnethoxyphenyl, and 1,3-benzcdioxol-5yi.
5. 9. A compound of claim £ is 4-chlorophenyl.
6. 10. A compound of claim S ?ai^⁵ in chloroform is negative, is 4-trifiucrcnethylphenyl.

   1-. A -nnnr-d nf rlA’

   characterized in that Ar characterized in that characterized in that Ar cha racteri zed in that Ar .in : ch^iaccei i. - hr ,enyl. characterized in that Ar ’ ; Z is oxygen; and Ar is ’henyl, 3-chlcr cchenyl, 4- methyiphenyl, 4-t -butyl-

   phenyl, 4-trifluorcmethylphenyl, 4-methoxyphenyl, 4ethoxyphenyi, 4-(2-fiucroethoxy)phenyl, 4-difiuorometnax-chenvl, 4-trifluoromethoxvoheny1, and 1,3-tenzcdicxcl-5-yi.

   15. A compound of claim 14 characterized in that Ar is 4-trifiucrcmethcxyphenyl.

   15. A compound of claim 3 characterized in that Ar :nyl; 3 is sulfur; and Ar' ;s selected frtm :cmpcuna of claim 15 characterized m that ^-4« — < 4 -Z S'* * i
7. 11. A ccnccund of claim 3 •ized in that is cxyger., ar.c A:

   BAD ORIGINAL

   -7219. A compound of claim 3 characterized in that Ar' is selected from 3-phenoxyphenyl, 4-fluorc-3-phencxyphen.yl, and 2-methyl[1,1'-biphenyl]-3-yl; Z is methylene; and Ar is selected from 3-chlorochenyl, 4-chloro5 phenyl, 4-methylphenyl, 4-ethoxyphenyl, and 4-trifluoromet.hoxyphenyl.

   20. A compound of claim 19 characterized in that Ar¹ is 3-phenoxyphenyl and Ar is 4-chlorcphenyl.

   21. A compound of claim 19 charaonerized in that j Ar ’ is 3-phencxychenyl and Ar is 4-trifluoreneohylo y/ 23. A compound of claim 19 characterized in that Ar'¹ is 4-f luorc-3-pher.oxyphenyl and Ar is 4-trifluoromethylphenyl.

   24. A compound of claim 19 characterized in that Ar' is 4-fluoro-3-phencxyphenyl and Ar is 4-triflucrcAr' is 2-methyi'1,1’-biphenyl’-3-yl and Ar is 4-trif luorcmet'nyiphenyl.

   26. A compound characterized by the formula;

   in whirr. Ar is a substituted or unsubstituted phenyl ;r thienyl and Ar' is a substituted or unsubstituted phe.ncxyphenyl, 2-methyl)1,1'-biphenyl]-3-yl, or 6-pheroxy-2in.

   C0^G

   -7327. A compound of claim 2S characterized in that Ar' is selected from 3-phenoxyphenyl and 4-fluoro-3phencxypr.enyl and Ar is selected from 4-chlorophenyl, 4bromophenyl, and 4-methoxyphenyl.

   28. A compound of claim 27 characterized in that Ar' is 4-fluoro-3-phenoxyphenyl and Ar is 4-chloropheny1.

   29. A compound characterized by the formula:

   in which Ar is a substituted or unsubstituted phenyl cr thienyl and Ar' is a substituted or unsubstituted phencxypho.nyl, 2-methyl;1,1'-biphenyl]-3-yl, or 6-phenoxy-2ί“. 7 ’ V- - 4 · 30. A compound of claim 25 characterized in that Ar' is selected from 3-phenoxyphenyl, 4-fluoro-3-phencxyphe.ty 1, and 2-methyl'1,1'-biphenyl]-3-yl and Ar is selectee from 4-chicrcph.enyl, 4-methylpr.enyl, 4-triflucrcnethyiphenyl, and 4-ethoxyphenyl.

   31. An insecticidal cr acaricidal composition characterized by an insecticidally or acaricidally effective amount cf a compound of claim 1 in admixture with -.-.a cr more compatible agricultural carriers, iziuonts. adjuvants, cr ccmplemendary pesticides.

   32. An insecticidal composition characterized by an insecticidally effective amount of a compound cf claim 2-5 in admixture with one or mere compatible agricultural carriers, diluents, adjuvants, or comp 1 eme.ntary insecticidally effec 29 in admixture with

   V S 0 0 0 OdV dal compositi.m. zh ar a itemized by an ive am.cu.nt cf a czmpzund of claim one or more compatible agricultural

   BAD ORIGINAL carriers, diluents, adjuvants, or complementary pesticides.

   34. A method of controlling insects and acarids characterized by applying to the locus where control is desired an insecticidally or acaricidally effective amount of a compound of claim 1.

   35. A method of controlling insects characterized by applying to the locus where control is desired an insecticidally effective amount cf a compound of claim

   A precess for preparing a ccmpcund cf the

   Ar-C:-;-2H₂-C-CH₂-Ar' in which Ar is a substituted cr un.substituted phenyl group and Ar' is a substituted or unsubstituted phenexyphenyl, 2-methyl;1,1'-biphenyl]-3-yl, cr 6-phencxy-2pyricyl group, characterized in that a ccmpcund of the formula

   Έ--Χ wherein X is a leaving'group capable of by ethoxide tons.

   beir.g .sc_ace :

   cP

   Ir

   75* 73. λ process for preparing a compound of the formula

   V ·

   Ar-CH-CH₂-S-CH₂Ar' in which Ar is a substituted or unsubstituted phenyl group and Ar' is a substituted or unsubstituted phenoxyphenyl, 2-methyl[1,1'-biphenyl)-3-yl, or 6-phenoxy-2pyridyl group, characterized in that a compound of the formula

   Ar-CH-c;-: - -s ~ is reacted with a compound of the formula

   Ar'-CH₂-X wherein X is a leaving group capable of being displaced ty thioechoxide ions.

   27. A process for preparing a compound of the formula Ϋ :o : . . j

   BAD ORIGINAL is reacted with a compound of the formula &'-ch₂.p(^J> )3j +C1Λ process for preparing a compound of the o r~ .. i a pyridyl group, characterised in that a compound of the f o r?- j 1 a

   H-CH

   H-A

   A proecus f or of ciic

   Luted -or unsucstituoed pher.cxyhenyl]-3-yl, or e-phenoxy-2Ar-C

   -77is reacted with a compound of the formula f7r'-CH₂CH2CH2‘P(^^)^l⁺Br-.

   42. A process for preparing a compound of the formula

   '.........V .....

   10 Ar-CH-CH₂CH₂CH₂-Ar' in which Ar is a substituted or unsubstituted phenyl group and Ar' is a substituted or unsubstituted phenoxyphenyl, 2-methy1[1,1'-biphenyl]-3-yl, or 6-phenoxy-215 pyridyl group, characterized in that a compound of the formula

   V

   Ar-C=0HCH₂CH₂-Ar' is hydrogenated.

   AP 0 0 0 0 5 4