AP291A - Use of a guanine derivative in the treatment of viral infections. - Google Patents
Use of a guanine derivative in the treatment of viral infections. Download PDFInfo
- Publication number
- AP291A AP291A APAP/P/1991/000290A AP9100290A AP291A AP 291 A AP291 A AP 291A AP 9100290 A AP9100290 A AP 9100290A AP 291 A AP291 A AP 291A
- Authority
- AP
- ARIPO
- Prior art keywords
- formula
- compound
- use according
- hiv
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Use of a guanine derivative or a prodrug thereof in the treatment of viral infections.
Description
PHARxMACEUT I CAL TREATMENT
This invention relates to a method of treatment of HIV-1 infection in humans and animals, and to the use of compounds in the preparation of a medicament for use in the treatment of such infection.
EP-A-141927 (Beecham Group p.l.c.) discloses penciclovir, the compound of formula (A):
and salts, phosphate esters and acyl derivatives thereof, as antiviral agents. The sodium salt hydrate of penciclovir is disclosed in EP-A-216459 (Beecham Group p.l.c.).
Penciclovir and its antiviral activity is also disclosed in Abstract P.V11-5 p.193 of 'Abstracts of 14th Int. Congress of Microbiology', Manchester, England 7-13 September 1986 (Boyd et. al.).
Pro-drugs of the compound of formula (A) are of formula (B)
NH.
HO-CH2-CH-CH -OH (B)
B3016 , j «ι MA
-2and salts and derivatives thereof as defined under formula (A); wherein X is C1_g alkoxy, NH2 or hydrogen. The compounds of formula (B) wherein X is C^_g alkoxy or NH2 are disclosed in EP-A-141927 and the compounds of formula (B) wherein X is hydrogen, disclosed in EP-A-182024 (Beecham Group p.l.c.) are preferred prodrugs. A particularly preferred example of a compound of formula (B) is that wherein X is hydrogen and wherein the two OH groups are in the form of the acetyl derivative, described in Example 2 of EP-A-182024, hereinafter referred to as famciclovir.
The compounds of formulae (A) and (B) and salts and derivatives thereof have been described as useful in the treatment of infections caused by herpesviruses, such as herpes simplex type 1, herpes simplex type 2, varicella-zoster and Epstein-Barr viruses.
It has now been discovered that these compounds have potential activity against the human immunodeficiency virus (HIV-l), in patients also infected with herpesviruses, and are therefore of potential use in the treatment of HIV infections in such patients.
This discovery is related to the ability of the triphosphate derivative of penciclovir to inhibit the RNA-directed DNA polymerase (reverse transcriptase) activity of human immunodeficiency virus type 1 (HIV-l). The reverse transcriptase of HIV-l is a virus-encoded enzyme essential for the conversion of genomic RNA into proviral ds-DNA, and is therefore an excellent molecular target for antiviral chemotherapy.
The ability of HIV to enter cells previously infected with herpesviruses is known (for example, B-lymphocytes infected with EBV1). The presence of both herpes and human immunodeficiency viruses in the same cell has particular consequences.
AP 0 0 0 2 9 1
B3016
-31. Penciclovir would be phosphorylated by herpes virus-encoded thymidine kinase leading to a high level of penciclovir triphosphate . The triphosphate formed is not only an inhibitor of herpes DNA polymerase, but this work indicates that it also inhibits HIV reverse transcriptase.
2. HIV replication may be enhanced by herpesvirus transactivating factors. A product of HSV, ICP-4 (infected-cell protein) can increase the initiation of HIV transcription.
3. Double infection of herpesviruses and HIV may result in phenotypic mixing and the production of 'pseudotype' HIV
-j particles bearing herpesvirus envelope glycoproteins . The packaging of HIV genomic RNA with HSV capsid proteins is also believed to occur. Either situation may lead to the infection by HIV of CD4-negative, herpesvirus-permissible cells, previously not susceptible to entry of this virus. This may also result in doubly-infected cells.
Accordingly, the present invention provides a method of treatment of HIV-1 infections in mammals, including humans, which mammals are infected with herpesviruses, which method comprises the administration to the mammal in need of such treatment, an effective amount of a compound of formula (A):
ho-ch2-ch-ch2-oh (A) i υ κι A A
B3016
-4or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing.
The term 'acyl derivative' is used herein to include any derivative of the compounds of formula (A) in which one or more acyl groups are present. Such derivatives are included as pro-drugs of the compounds of formula (A) in addition to those derivatives which are per se biologically active.
Examples of pro-drugs, pharmaceutically acceptable salts and derivatives are as described in the aforementioned European Patent references, the subject matter of which are incorporated herein by reference.
A particular pro-drug of interest is 9-(4-acetoxy-3acetcxymethylbut-l-yl)-2-aminopurine, known as famciclovir.
The compound of formula (A) may also be in one of the forms disclosed in EP-A-216459 (Beecham Group p.l.c.).
The compound of formula (A), pro-drugs, salts and derivatives may be prepared as described in the aforementioned European Patent references.
The compound, in particular, famciclovir, may be administered by the oral route to humans and may be compounded in the form of syrup, tablets or capsule. When in the form of a tablet, any pharmaceutical carrier suitable for formulating such solid compositions may be used, for example magnesium stearate, starch, lactose, glucose, rice, flour and chalk. The compound may also be in the form of an ingestible capsule, for example of gelatin, to contain the compound, or in the form of a syrup, a solution or a suspension. Suitable liquid pharmaceutical carriers include ethyl alcohol, glycerine, saline and water to which flavouring or colouring agents may be added to form syrups.
AP 0 0 0 2 9 1
B3016
-5For parenteral administration, fluid unit dose forms are prepared containing the compound and a sterile vehicle. The compound depending on the vehicle and the concentration, can be either suspended or dissolved. Parenteral solutions are normally prepared by dissolving the compound in a vehicle and filter sterilising before filling into a suitable vial or ampoule and sealing. Advantageously, adjuvants such as a local anaesthetic, preservatives and buffering agents are also dissolved in the vehicle. To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum.
Parenteral suspensions are prepared in substantially the same manner except that the compound is suspended in the vehicle instead of being dissolved and sterilised by exposure to ethylene oxide before suspending in the sterile vehicle. Advantageously, a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the compound of the invention.
Preferred parenteral formulations include agueous formulations using sterile water or normal saline, at a pK of around 7.4 or greater, in particular, containing penciclovir sodium salt hydrate.
As is common practice, the compositions will usually be accompanied by written or printed directions for use in the medical treatment concerned.
An amount effective to treat the virus infection depends on the nature and severity of the infection and the weight of the mammal.
A suitable dosage unit might contain from 50mg to lg of active ingredient, for example 100 to SOOmg. Such doses may be administered 1 to 4 times a day or more usually 2 or 3 times a day. The effective dose of compound will, in
B3016 / ή υ (,
-6general, be in the range of from 0.2 to 40mg per kilogram of body weight per day or, more usually, 10 to 20 mg/kg per day .
The present invention also provides the use of a compound of formula (A) or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing, in the preparation of a medicament for use in the treatment of HIV-1 infections in mammals, including humans, which mammals are infected with herpesviruses. Such treatment may be carried out in the manner as hereinbefore described.
The present invention further provides a pharmaceutical composition for use in the treatment of HIV-1 infections in mammals, including humans, which mammals are infected with herpesviruses, which comprises an effective amount of a compound of formula (A) or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing, and a pharmaceutically acceptable carrier. Such compositions may be prepared in the manner as hereinafter described.
The compound of formula (A) and its prodrugs show a synergistic antiviral effect in conjunction with interferons; and treatment using combination products comprising these two components for sequential or concomitant administration, by the same or different routes, are therefore within the ambit of the present invention.
Such products are described in EP-A-271270 (Beecham Group p.1.c.).
It will be appreciated that the treatment of herpesvirus infected patients may include prophylaxis of herpesvirus episode attacks (suppressive treatment). In patients with
AP Ο Ο Ο 2 9 1
B3016
-7HSV infection only, suppressive treatment would probably only be given to those patients with frequent recurrences. In contrast, the aforementioned finding in relation to HIV 1, indicates the need for continuous suppressive treatment with penciclovir to all HIV-l infected patients with herpesvirus recurrences, particularly HSV-1, HSV-2 and VZV recurrences, even though these recurrences may be infrequent.
io The following biochemical data illustrate the invention.
B3016
-8BIOCHEMICAL DATA
Materials and Methods
Chemicals [3H]dGTP (16.3 Ci/mmol) was purchased from Amersham International, Aylesbury, U.K. Template primer Poly (rC) . p(dG) 12-I8 rC:dG ratio) and
2',3'-dideoxyguanosine-5-triphosphate (ddGTP) were obtained from Pharmacia Ltd., Milton Keynes, U.K. Penciclovir triphosphate (PCV-TP) was prepared in the laboratories of SmithKline Beecham Pharmaceuticals, Great Burgh, United Kingdom.
Reverse transcriptase Purified, E. coli expressed HIV-1 reverse transcriptase (RT) was supplied by the Protein Biochemistry Department of SmithKline 3eecham Pharmaceuticals, Upper Merion, U.S.A. The enzyme was stored and diluted in a buffer containing 50mM Tris-HCl (pH 8.0), lOmM Hepes, HOmM NaCl, 5.7mM DTT, 0.3mM EDTA, 0.06% Triton X-100, 50% glycerol.
Assay for reverse transcriptase activity The reaction mixture for the HIV-1 RT assay contained in a volume of 120μ1: 33mM Tris HCl (pH 8.0), lOOmM KC1, 3.3mM MgCl2, 3.3mM dithiothreitol, 0.2mM glutathione, 0.33mM EGTA (ethylene glycol-bis-(β-aminoethyl ether) Ν,Ν-tetra acetic acid), 0.033% Triton X-100, 1.02μΜ [3H]dGTP, 0-12.39μΜ inhibitors ddGTP, PCV-TP, 0.3 A260 units/ml Poly (rC) . p(dG)12_18 and
167ng/ml RT (equivalent to 2.85nM for an equimolar mixture of p66 and p51 polypeptides). The reaction mixtures without RT were prepared in the microwells of a 96-well plate and preincubated at 37°C before the reactions were started by the addition of 20μ1 of the enzyme solution. The plates were then incubated for 65 minutes at 37°C. The incorporation rate was linear for the uninhibited control reaction over this time period. The reactions were terminated by the addition of 40μ1 of EDTA solution (0.2M,
AP 0 0 0 2 9 1
B3016
-9pH7.0). The individual reaction mixtures were transferred to a DEAE filter mat (1205-405, LKB Wallac, Finland), prewetted with 0.3M NaCl/0.03M Na citrate, using a cell harvester (1295-001, LKB Wallac) . The filter mat was washed three times in the NaCl/Na citrate buffer and then once in 95% ethanol. Scintillation fluid (Beta Plate Scint, LKB Wallac) was added to the dried filter, and the reaction mixtures assayed for incorporation of radioactive dGMP in an LKB 1205 Beta Plate Liquid Scintillation Counter.
Results
The counts per minute obtained with the uninhibited control reaction mixture, and with a range of concentrations of ddGTP and PCV-TP, are shown in Tables 1 and 2 respectively. From the plots of % inhibition against concentration of inhibitor, approximate IC5Q values were obtained as follows :ddGTP: 25nM (R/S)PCV-TP: 4.3μΜ
Conclusion
These results indicate that the concentration of penciclovir triphosphate required to give 50% inhibition of HIV-1 reverse transcriptase is approximately 4μΜ. This level of PCV-TP should be obtained in the herpes-infected cell2.
- <> ΜΑ
Β3016
-10Table 1
Inhibition of HIV-l Reverse Transcriptase by ddG-Triphosphate
Concentration of ddGTP (nM) | Incorporation of dGMP (c.p.m.) | % Inhibition |
0 | 117892 | |
1 | 119726 | 0 |
10 | 89949 | 23.7 |
25 | 58703 | 50.2 |
50 | 35091 | 70.2 |
75 | 26132 | 77.8 |
100 | 22161 | 81.2 |
Table 2
Inhibition of HIV-l Reverse Transcriptase by
PCV-Triphosphate
Concentration | Incorporation of | % Inhibition |
of PCV-TP (μΜ) | dGMP (c.p.m.) |
0 | 88892 | |
0.124 | 85313 | 4.0 |
1.24 | 70061 | 21.2 . |
3.10 | 51866 | 41.7 |
6.19 | 32921 | 63.0 |
9.29 | 26436 | 70.3 |
12.39 | 23844 | 73.2 |
AP Ο Ο Ο 2 9 1
Β3016
-11References
1. Complement Receptor 2 Mediates Enhancement of Human Immunodeficiency virus infection in Epstein-Barr virus-carrying B cells.
Tremblay et al., J. Exp. Med. 171, 1791 (1990).
2. Mode of action of 9-(4-hydroxy-3-hydroxymethylbut1-yl)guanine (BRL 39123) against herpes simplex virus io in MRC-5 cells.
Vere Hodge and Perkins, A.A.C., 33./ 223 (1989).
3. Phenotypic mixing between human immunodeficiency virus and vesicular stomatitis virus or herpes simplex virus .
Zhu et al., J. of AIDS, 3, 215 (1990).
Claims (9)
- ClaimsUse of a compound of Formula (A) :cr a pre-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the10 foregoing; in the manufacture of a medicament for itae'-’in lίnaT8e«e—e-f HIV-l infections in mammals, which mammals are infected with herpesviruses.
- 2. A use according to 15 ccmpcund is penciclovir,
- 3. A use according to compound is the sodium s formula (A) .
- 4. A use according to is in an aqueous formula vim: : f’.-gfgcn .claim 1, - or-3 wherein the of formula (A).ar claim ’.^2 ar wherein the ilt hydrate of the compound of claim 5 wherein the medicament iοn^Adapted For parentage 125 5. A use according to claim 1, wherein the ccmpcund is a pro-drug cf the compound of formula (A), of formula (2) :SAPB7016/XΑΡ00Ό29 1 (B)
- 5 or a salt or derivative thereof, as defined in respect of formula (A) in claim 1; wherein X is Cq_g alkoxy, NH2 or hydr ogen .
- 6. A use according to claim *7 wherein the pro-drug 10 compound of formula (B) is wherein X is hydrogen, or a derivative thereof, as defined in respect of formula (A) in claim 1.
- 7. A use according to claim wherein the pro-drug 15 compound of formula (3) is famciclovir, wherein X is hydrogen and wherein the two OH groups are in the form of the acetyl derivative.
- 8. A use according to claim wherein the medicament 20 is adapted for oral administration.
- 9. A use according to claim 1^—5—uo wherein the compound administered is in a 5Cmg t: lg unit dose.25 10. Penciclovir, or a pro-drug therefor, for use in continuous suppressive treatment of HIV patients with HSV or V27 recurrences.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909015051A GB9015051D0 (en) | 1990-07-07 | 1990-07-07 | Pharmaceutical treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
AP9100290A0 AP9100290A0 (en) | 1991-07-31 |
AP291A true AP291A (en) | 1993-12-29 |
Family
ID=10678814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1991/000290A AP291A (en) | 1990-07-07 | 1991-07-05 | Use of a guanine derivative in the treatment of viral infections. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0538305B1 (en) |
JP (1) | JP2764656B2 (en) |
KR (1) | KR100196339B1 (en) |
AP (1) | AP291A (en) |
AT (1) | ATE151291T1 (en) |
AU (1) | AU647807B2 (en) |
CA (1) | CA2086756C (en) |
DE (1) | DE69125610T2 (en) |
DK (1) | DK0538305T3 (en) |
ES (1) | ES2101747T3 (en) |
GB (1) | GB9015051D0 (en) |
GR (1) | GR3023611T3 (en) |
HK (1) | HK1004527A1 (en) |
IE (1) | IE912358A1 (en) |
IL (1) | IL98749A (en) |
WO (1) | WO1992000742A1 (en) |
ZA (1) | ZA915214B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6124304A (en) * | 1993-10-05 | 2000-09-26 | Smithkline Beecham Plc | Penciclovir for the treatment of zoster associated pain |
GB9326177D0 (en) * | 1993-12-22 | 1994-02-23 | Smithkline Beecham Plc | Pharmaceuticals |
US6683084B1 (en) | 1993-11-12 | 2004-01-27 | Novartis International Pharmaceutical Ltd. | Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections |
GB9323403D0 (en) * | 1993-11-12 | 1994-01-05 | Smithkline Beecham Plc | Pharmaceuticals |
GB9323404D0 (en) * | 1993-11-12 | 1994-01-05 | Smithkline Beecham Plc | Pharmaceuticals |
UA51640C2 (en) * | 1994-12-12 | 2002-12-16 | Смітклайн Бічам Плс | Method for preventing establishment or reactivation of latent infection of herpes viruses |
US5840763A (en) * | 1994-12-12 | 1998-11-24 | Smithkline Beecham Plc | Treatment of a latent infection of herpes viruses |
GB9504497D0 (en) | 1995-03-07 | 1995-04-26 | Smithkline Beecham Plc | Pharmaceuticals |
ES2203692T3 (en) * | 1995-04-24 | 2004-04-16 | Novartis International Pharmaceutical Ltd. | USE OF (R) -PENCICLOVIR TRYPHOSPHATE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF VIRIC DISEASES. |
GB9601544D0 (en) | 1996-01-26 | 1996-03-27 | Smithkline Beecham Plc | Pharmaceuticals |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0216459A1 (en) * | 1985-07-27 | 1987-04-01 | Beecham Group Plc | 9-Substituted guanine monohydrates |
EP0271270A2 (en) * | 1986-12-02 | 1988-06-15 | Beecham Group Plc | Pharmaceutical products |
EP0306844A2 (en) * | 1987-09-11 | 1989-03-15 | Hoechst Aktiengesellschaft | Use of 6-mercaptopurines in the preparation of a pharmaceutical composition, and method for preparing this composition |
AT388500B (en) * | 1987-10-27 | 1989-06-26 | Wellcome Found | Antiviral 8-phenylxanthines |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3485225D1 (en) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | ANTIVIRAL GUANINE DERIVATIVES. |
-
1990
- 1990-07-07 GB GB909015051A patent/GB9015051D0/en active Pending
-
1991
- 1991-07-03 DE DE69125610T patent/DE69125610T2/en not_active Expired - Lifetime
- 1991-07-03 JP JP3511884A patent/JP2764656B2/en not_active Expired - Fee Related
- 1991-07-03 CA CA002086756A patent/CA2086756C/en not_active Expired - Lifetime
- 1991-07-03 DK DK91912424.8T patent/DK0538305T3/en active
- 1991-07-03 AT AT91912424T patent/ATE151291T1/en not_active IP Right Cessation
- 1991-07-03 WO PCT/GB1991/001082 patent/WO1992000742A1/en active IP Right Grant
- 1991-07-03 EP EP91912424A patent/EP0538305B1/en not_active Expired - Lifetime
- 1991-07-03 AU AU81032/91A patent/AU647807B2/en not_active Expired
- 1991-07-03 ES ES91912424T patent/ES2101747T3/en not_active Expired - Lifetime
- 1991-07-05 IE IE235891A patent/IE912358A1/en not_active IP Right Cessation
- 1991-07-05 ZA ZA915214A patent/ZA915214B/en unknown
- 1991-07-05 AP APAP/P/1991/000290A patent/AP291A/en active
- 1991-07-05 IL IL9874991A patent/IL98749A/en not_active IP Right Cessation
- 1991-07-31 KR KR1019930700034A patent/KR100196339B1/en not_active IP Right Cessation
-
1997
- 1997-05-30 GR GR970401255T patent/GR3023611T3/en unknown
-
1998
- 1998-04-28 HK HK98103626A patent/HK1004527A1/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0216459A1 (en) * | 1985-07-27 | 1987-04-01 | Beecham Group Plc | 9-Substituted guanine monohydrates |
EP0271270A2 (en) * | 1986-12-02 | 1988-06-15 | Beecham Group Plc | Pharmaceutical products |
EP0306844A2 (en) * | 1987-09-11 | 1989-03-15 | Hoechst Aktiengesellschaft | Use of 6-mercaptopurines in the preparation of a pharmaceutical composition, and method for preparing this composition |
AT388500B (en) * | 1987-10-27 | 1989-06-26 | Wellcome Found | Antiviral 8-phenylxanthines |
Also Published As
Publication number | Publication date |
---|---|
AP9100290A0 (en) | 1991-07-31 |
JP2764656B2 (en) | 1998-06-11 |
HK1004527A1 (en) | 1998-11-27 |
IL98749A (en) | 1995-03-30 |
KR100196339B1 (en) | 1999-06-15 |
ATE151291T1 (en) | 1997-04-15 |
AU8103291A (en) | 1992-02-04 |
EP0538305B1 (en) | 1997-04-09 |
JPH05507719A (en) | 1993-11-04 |
WO1992000742A1 (en) | 1992-01-23 |
GB9015051D0 (en) | 1990-08-29 |
AU647807B2 (en) | 1994-03-31 |
DK0538305T3 (en) | 1997-10-13 |
CA2086756C (en) | 2003-04-08 |
EP0538305A1 (en) | 1993-04-28 |
IE912358A1 (en) | 1992-01-15 |
ZA915214B (en) | 1992-06-24 |
CA2086756A1 (en) | 1992-01-08 |
DE69125610T2 (en) | 1997-11-20 |
ES2101747T3 (en) | 1997-07-16 |
IL98749A0 (en) | 1992-07-15 |
DE69125610D1 (en) | 1997-05-15 |
GR3023611T3 (en) | 1997-08-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20030109498A1 (en) | Antiviral agent for drug-resistant virus | |
AP291A (en) | Use of a guanine derivative in the treatment of viral infections. | |
US10463664B2 (en) | Inhibitors of HSV nucleotidyl transferases and uses therefor | |
AU628137B2 (en) | Pharmaceutical treatment | |
US5674869A (en) | Pharmaceutical treatment | |
IE921156A1 (en) | Pharmaceuticals | |
EP0728002B1 (en) | Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 7 infection | |
JP2007297412A (en) | Use of penciclovir for treatment of human herpes-virus-8 | |
US20220348546A1 (en) | Sulfur and amide tropolone inhibitors of nucleotidyl transferases and uses therefor | |
AU690159B2 (en) | Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections | |
US6683084B1 (en) | Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections |