FR2749662A1 - ROBOTIZED LABORATORY OF SAMPLES ANALYSIS - Google Patents

Abstract

The invention discloses a robotized laboratory for product sample analysis of products, comprising a plurality of analysers, characterised in that it further comprises premises (1) divided into two adjacent zones, called robot zone (2) and operator lock chamber (3). The robot zone (2), comprising a rotoid industrial robot (5) with six working axles, communicates with the operator lock chamber (3) by means of bi-directional conveyors (9) transporting sample containers. The invention is useful in control or research laboratories in pharmaceutical, oil, chemical, petrochemical industries and in medical analysis laboratories.

Description

TECHNICAL AREA
The present invention relates to a robotic laboratory for analyzing samples which, in particular, ensures total traceability of the analysis by constant monitoring of the samples being analyzed. It finds its application in control and research laboratories of the pharmaceutical, petroleum, chemical, petrochemical industries in medical analysis laboratories, and in general in all laboratories in which numerous and repetitive analyzes must be carried out.

STATE OF THE PRIOR ART
In many control and research laboratories, there must be repetitive and numerous analyzes.

 To this end, some laboratories are equipped with workstations which carry out a limited number of operations. To carry out a complete analysis, several control stations must be used. In the document ANALYTICAL CHEMISTRY Vol 62 n01, January 1, 1990 pages 29A to 34A (Send in the robots A.R. Newman) laboratory equipment is described, which includes seven workstations. Vials of samples identified by bar codes are moved by elevators and conveyors between the areas where workstations performing specialized tasks are installed. At the various workstations, pneumatically controlled arms and devices perform the functions dedicated to them. Each arm or device performs a specific task, which increases the precision of the operation.

 The workstations are equipped with microcomputers connected to a central computer which centralizes the information and communicates with a database in which the preparation information is collected.

 The laboratory thus described uses the same principles as those used for the production of automated assembly lines, such as those in the automotive industry, in which the assembled object is moved by conveyors between a series of robots which perform basic tasks, for example, welding, drilling, painting.

 Such a laboratory is complex and expensive because of the high cost of workstations, each of which requires its own robot and conveyors.

 Another automated analysis laboratory is described in document WO 93/15407. According to this document, the elementary analysis operations are carried out by known devices assembled according to the specific rules and adapted to the analyzes to be carried out. All these devices interact with at least one robot, under the control of a computer, equipped with a suitable program to which they are connected by means of suitable interfaces.

 The laboratories described in these documents do not allow automatic monitoring of samples since their arrival in the laboratory and during handling by robots. It is therefore not possible to provide posteriori proof of the good progress of the analyzes, and that confusion between samples has not been made.

 The robots used in the automated laboratories described above have only five degrees of freedom, which limits their ability to position an object in space; moreover, they are not designed to operate continuously 24 hours a day. There is no provision for easy maintenance or decontamination when dangerous products have been handled.

 For safety reasons, an operator must not be able to approach the robot (s) during their operation. Given the risks of mechanical shock and of projection of dangerous products, the solution generally adopted to limit these risks consists in cutting the energy supply to the motors of the robots.

This solution is not very effective because it intervenes after the possible collision.

 On the other hand, the automatic distribution of a sample, in each of the containers of a support, requires knowing the exact position of at least one container in space, which is not possible with known laboratories. .

 In these same laboratories, there are distributors of test tubes and filters, but these devices do not allow the automatic distribution of other accessories such as micro-flasks provided with septum, cups or syringes, which are essential for the complete automation of an analysis.

Known laboratories are equipped with stations for checking the dimensions of capsules and tablets of the mechanical type, comprising - a fixed jaw and a movable jaw - a motor for moving the movable jaw - means for measuring the jaw spacing
The sample whose dimensions are to be determined is placed between the jaws. The movable jaw is moved until it comes into contact with the sample to be measured which abuts on the fixed jaw.

 In this position, the jaw spacing measurement means deliver an electrical signal representative of the size of the sample. With this device, only one measurement is made at a time; if you want to know two dimensions, you have to repeat the operation.

This device is ill-suited for measuring the dimensions of oblong tablets, because one is never sure of the position of the sample between the jaws. It is also ill-suited for measuring the dimensions of fragile samples. In the known automated laboratories, the robots are provided with grippers with 2 or 3 fingers which are badly adapted to the grip of objects of various forms.

 Another drawback of known automated laboratories is that they do not have a station for distributing an automated liquid sample. To distribute a liquid sample contained in a first container, in other containers whose opening is provided with septum, one solution consists in using an intermediate reservoir provided with a hollow needle which makes it possible to perforate the septum.

The containers being simply placed on a portion, after perforation the containers remain suspended on the needle by pinching effect of the septum, which requires a manual operation. The syringe used as an intermediate reservoir has a piston controlled by a linear motor. This device is complex and, due to the moving parts, it is subject to wear by friction.

STATEMENT OF THE INVENTION
The present invention relates to a robotic laboratory for analyzing samples in liquid, solid or pulverulent form, efficient, suitable for continuous operation 24 hours a day in complete safety ensuring the traceability of operations.

 This laboratory comprising a plurality of analyzers is characterized in that it further comprises a room separated into two contiguous non-communicating zones for an operating operator, one of said zones being called "robotic zone" and the other "operator sas ", the robotic zone comprising at least one rotary industrial robot with at least five working axes, mounted on a horizontal displacement rail giving it an additional working axis, provided with means of displacement on said rail and with an industrial gripper with its end and connected to a control system, a robot work plan placed below the robot supporting the analyzers, the operator airlock comprising a work plan for the operating operator, two-way container transfer conveyors containing the samples, between the robotic area and the operator airlock.

According to another characteristic of the invention, the robot displacement rail has a length greater than the length of the robot work surface so as to allow the robot to access two maintenance zones located beyond the ends of said work plane.
According to another characteristic, the laboratory also includes self-test means for the repeatability of the positioning of the robot in space along its working axes.

 According to a particular embodiment, the robot repeatability self-test means comprise at least one fixed device chosen from micro-contacts, proximity sensors, laser detectors suitably distributed in space and mobile means for activating said devices. , carried by the robot gripper.

 According to another characteristic, the laboratory further comprises at least one rack of sample containers, mounted on supports, comprising circular locations for said supports, said racks and said supports being provided with means for angular positioning of each support in a location. .

According to a particular embodiment, the angular positioning means comprise an effect sensor
Hall fixed to the rack and a magnet secured to the support.

 According to a particular embodiment, the angular positioning means comprise a video camera, image processing means and means for angular location of each container in each location.

 According to a particular embodiment, the laboratory further comprises an automatic distributor of cylindrical syringes provided with eccentric tips, comprising a support block with recesses of shape adapted to housing the ends of the syringes and tips, a movable tray provided with means of displacement and a position detector.

 According to another characteristic, the laboratory further comprises an accessory distributor comprising two vertical parallel flanges, superimposed, inclined plates, arranged in Z integral with the flanges, flaps articulated around the upper edge of each plate, mounted on a rotating horizontal base. with two stable positions offset by 900 provided with means of rotation and immobilization in the two stable positions, the lower plate being provided with a vertical rim for stopping the accessories allowing the said accessories to be taken up by the robot at a location unique.

 According to another characteristic, the laboratory also includes a dimensional control station for a sample comprising a working block comprising two coaxial conical holes with vertical axis, respectively upper and lower, a horizontal slot separating the two conical holes, a drawer movable in the slot closing the lower part of the upper conical hole provided with means of displacement in a horizontal plane, a sample transfer cup, a movable cup holder mounted on a horizontal slide, placed below the work block provided in its part upper of a counterbore of the bucket centered in the axis of the conical holes and comprising means of horizontal displacement, a video camera placed above the work block in the axis of the conical holes and electronic means for processing images.

 According to another characteristic, the laboratory comprises a universal gripping adapter consisting of a cylindrical-conical block comprising a cylindrical groove provided with two flat receiving sectors of the industrial gripper of the robot.

 According to a particular embodiment, the universal gripping adapter further comprises a glass vial stopper fixed at the end of its conical part.

 According to a particular embodiment, the universal gripping adapter further comprises an axial cylindrical recess intended to receive a cannula.

 According to a particular embodiment, the universal gripping adapter further comprises two opposite axial frustoconical recesses for mounting a tip adapted to the shape and size of a tablet or capsule.

 According to another characteristic, the laboratory comprises at least one liquid distribution station comprising a fixed frame, at least one tube of liquid to be distributed, at least two receiving bottles, a mobile support of tubes and bottles, provided with means for horizontal displacement. and vertical, a syringe secured to the fixed frame provided with a vertically mounted hollow needle, connected to suction means and delivery means, a movable presser foot crossed by the needle, a return spring for the foot -of the crowbar in the position remote from the syringe, a mechanical stop.

 According to another characteristic, the laboratory includes a sample positioner comprising suitable means for gripping said sample, a video camera and image processing means.

 According to another characteristic, the laboratory includes a bottle stopper consisting of a first cylindrical block comprising a lateral groove provided with two flat sectors for receiving the industrial gripper of the robot and a second coaxial cylindrical block of diameter less than the diameter of the first block and equal to the diameter of the stopper bottle.

 According to another characteristic of the invention, the samples and the containers used by the robot being provided with identifiers, the laboratory also comprises a manual reader of said identifiers placed in the operator lock, an automatic reader of identifiers of the containers placed on the robot work plan, a supervision computer system connected to the robot control system, to the analyzers, said computer system having access to a database relating to the analysis procedures and to a database relating to the results of said analyzes.

BRIEF DESCRIPTION OF THE DRAWINGS
The invention will be better understood on reading the description below with reference to the accompanying drawings in which - Figure 1 shows a schematic plan of implantation
main elements of the laboratory, - Figure 2 shows a container rack
of samples, - Figure 3a schematically shows a dispenser
accessories in a vertical section, - Figure 3b shows an accessory distributor seen
from above, - Figure 3c shows three trays of a dispenser
accessories, - figure 3d represents the lower end of the tray
bottom of an accessory dispenser, - Figure 4a shows a control station
dimensional of samples in vertical section, - Figure 4b shows a top view of a station
of dimensional control of samples, - Figure 5a shows a universal adapter
gripping, - Figure 5b shows a universal adapter
grip for glass bottle cap, - Figure 5c shows a universal adapter
gripping for a filling cannula, - Figure 5d shows a universal adapter
gripping, - Figure 5e shows a universal adapter
gripping for ballast recuperator, - Figure 6 shows a distribution station for
liquid, - Figure 7a schematically shows a dispenser
automatic syringes; with syringes properly
placed, - Figure 7b schematically shows a dispenser
automatic syringe, with a misplaced syringe, - Figure 8 shows a bottle cap.

DETAILED DESCRIPTION OF THE INVENTION
With reference to FIG. 1, the robotic laboratory for analyzing samples of the invention comprises a room 1 separated into two contiguous zones 2 and 3 respectively called robotic zone and its operator.

 In zone 2 robotics there is an industrial robot 5, a rotoid with six working axes suspended from a rail 6 placed above a work surface 4 of the robot 5.

 The work plan 4 of the robot 5 supports analyzers 7, 11, 12 and 13 such as apparatuses for chemical analysis, apparatuses for determining physical or dimensional characters. In the airlock 3, there is a work plan 8 for the operator.

 Between the robotic zone 2 and the airlock 3 there are bidirectional conveyors 9.

 The robot 5 is, moreover, provided with means of movement on the rail 7 not shown in Figure 1, .and an industrial gripper 10 at its end. The robot 5 is connected to a control system not shown in the figures.

 The samples to be analyzed, deposited on the work plan 8 for the operator, are placed in appropriate containers then placed manually on the conveyors which convey them to the robotic zone 2 above the work plan of the robot 5. Thanks to its gripper 10 , the robot 5 picks up the sample container, distributes it in suitable containers and places it on one of the analyzers 7.

When the analysis is complete, the robot takes up the rest of the sample and places it on a conveyor 9 which brings it back into the operator airlock.

 Thanks to these provisions, the operator does not need to access the robotic zone when the robot is in operation. A locking device for the access door to this area completes the installation to avoid any risk of penetration when the robot is in operation.

A specific programmed stop procedure allows the robot 5 to complete the movement in progress before authorizing the unlocking of the access door.

 One of the characteristics of the invention is the use of a 6-axis industrial rotunda robot, mounted on a rail which allows the gripper mounted at the end of the robot to access with very high precision at any point of a zone. extended access.

 According to the invention, the rail 6 of linear movement of the robot is extended at its two ends so that the robot accesses two zones (14, 15) outside of the work surface 4 in which it is easily accessible for carrying out maintenance operations. , and / or tests and / or decontamination. A particularly efficient self-test device uses laser detectors.

This device includes - a portable laser transmitter placed on the work surface of the
robot.

- laser receivers fixed in the area
robotics connected to the control system.

 To carry out the self-tests, the robot grasps the laser transmitter by means of its gripper, places itself in the predetermined test positions along the rail and successively targets the attached laser receivers. If all the receivers sequentially receive the laser beam emitted by the transmitter carried by the robot, the test result is positive. For all cases a test report is printed.

 According to FIG. 2 representing a rack 24, containers 20 of samples are mounted on supports 21, comprising six locations 22. These supports 21 being mounted in known manner in countersinks 23 of the rack 24.

 The characteristic of the invention consists in attaching a magnet 25 to each support 21 and to a magnetic detector 26 at each counterbore 23, and in connecting the detectors 26 to a processing electronics.

 When the robot places a support 21 in a counterbore 23, it rotates it until the processing electronics detects that the magnet 25 is facing the detector 26. Thus the support 21 for the sample is angularly positioned on the rack 24. Different types of detectors can be used, in particular Hall effect sensors.

According to FIGS. 7a and 7b, the laboratory of the invention comprises - an automatic syringe distributor 85, 86, 87
cylindrical with tips 89 and 90.

- a block 91 support with recesses 92,93,94,95.

- A mobile tray 88 provided with means 96 for movement.

- a position detector 97.

 The syringes 86, 87 are positioned manually by the laboratory operator, in each location of the support 85. The support is then placed under the plate 88 which descends until it is in contact with, as the case may be, with at least one or all syringes. If all the syringes are placed correctly, the detector 97 is activated by lowering the tray. If at least one syringe is incorrectly positioned in its location, the plate 88 is stopped before the activation position of the detector 97.

The operator is alerted to this anomaly.

According to FIGS. 3a, 3b, 3c and 3d, the laboratory of the invention comprises a distributor 31 of accessories 32 comprising - two vertical flanges 33 and 34 adapted to the width of
the accessory.

- 35 stacked trays.

- flaps 36 articulated around the upper edge 37 of
each tray 35.

- a horizontal circular base 38 provided with two notches
39 and 40.

- An immobilization device 42.

-a vertical rim 43 of the lower plate.

 In addition, the dispenser comprises means of displacement in rotation not shown. The notches 39 and 40 cooperate with the immobilizing device 42 secured to the work surface on which the distributor is placed to determine two positions of the flanges 33 and 34 offset by 900. One being the loading position for accessories shown in dotted lines in Figure 3b and the other the position of attachment of the accessories by the robot.

The flaps 36 are folded down to allow the loading of each tray from the lower tray, then returned to the position perpendicular to each tray.
According to FIGS. 4a and 4b, the invention comprises a dimensional control station 45 for a sample 46 comprising - a working block 47 provided with two holes 48 and 49
concentric frustoconical with vertical axis respectively
upper and lower.

a horizontal slot 50 separating the two holes 48 and
49.

- A movable drawer 51, provided with non-moving means
represented.

- A sample transfer cup 52.

- a bucket holder 53 movable in a horizontal plane
having a counterbore 55 and provided with displacement means
not shown.

- A horizontal slide 54.

- a video camera 57 placed in the axis 56 of block 47.

- electronic image processing means not
represented.

 The robot by means of the gripper mounted at its end, deposits a sample 46, placed in a transfer cup 52, in the upper conical hole 48 of the block 47.

The drawer 51 is in the closed position of the hole 48.

 The robot deposits the transfer cup 52 on the cup holder 53, which is in the position shown in FIG. 4b.

 The sample 46 is located at the bottom of the hole 48 on the upper part of the drawer 51.

 The video camera 57 takes an image of the sample 46 and transmits it to the processing electronics which analyzes it and simultaneously determines the desired parameters length, width, barycenter. This device also makes it possible to detect samples outside dimensional tolerances.

 The bucket holder 53 is then moved so that the opening of the bucket 52 is located below the conical hole 49 and its axis coincides with the axis 56.

 The drawer 51 is moved outside the slot out of the hole 48 by action on its displacement means.

The sample, under the effect of its weight, crosses the hole 49 and falls into the cup 52.

 The bucket holder 53 is then moved to the position shown in FIG. 4b where it is accessible to the robot.

 With this procedure, the same transfer cup is always used to move a given sample.

 According to FIG. 5a, the invention comprises a universal gripping adapter 60, of which a part 61 is cylindrical and the other 62 frustoconical.

 Thanks to a cylindrical groove 63 provided with two planar sectors 68 arranged on the cylindrical part, it can be gripped by the gripper of the robot.

 This universal adapter constitutes the basic support for various accessories such as a bottle cap 64, represents FIG. 5b, a cannula 65 for filling the container represents FIG. 5c, an endpiece 66 for capsule or tablet represents FIG. 5d or a ballast recuperator 67 shown in Figure 5e.

According to another characteristic, the laboratory of the invention comprises a liquid distribution station shown in FIG. 6 which comprises - a fixed frame 70, - a support 71 movable in vertical translation and
horizontal, - at least one tube 72 containing the liquid to be distributed.

- at least two 73.74 receptor vials, provided with septa, - a syringe 75 secured to the frame 70 provided with a needle
76 digs at its lower part, - suction means 80 connected to the upper part
of the syringe 75, - delivery means 81 connected to the part
upper part of the syringe 75, - two solenoid valves, - a crowbar 78 movable vertically, - a return spring 77, - a mechanical stop 79 secured to the frame 70.

 The mobile support 71 is equipped with horizontal and vertical displacement means.

 To transfer the liquid contained in the tube 72 into the bottles 73 and 74, the movable support 71 is moved so that the needle 76 is substantially in the axis of the tube 72, then it is lifted so that the needle 76 is slightly above the bottom of the tube 72.

The suction means 80 are placed in communication with the interior of the syringe 75, by action on the solenoid valve 84, for the time necessary for filling the syringe 75.

 The support 71 is then lowered and then placed horizontally so that the needle 76 is substantially in the axis of the bottle 73, then reassembled.

 The needle 76 pierces the septum which closes the entry of the bottle 73. During the upward movement of the support 71, the presser foot 78 slides vertically on the frame 70 by compressing the spring 75.

 The delivery means 8 are placed in communication with the interior of the syringe 75 by action on the solenoid valve 83 the time necessary for filling the bottle 73. When the filling is completed, the support 71 descends. The compressed spring 77 acts on the presser foot 78, which holds the bottle against the support during the descent. The mechanical stop 79 is adjusted in a vertical position so that the end of the needle 76 is released from the septum at the end of its travel. Thus the bottle 73 does not remain suspended from the needle.

 The same operation is repeated for all the bottles to be filled.

 According to another characteristic of the invention, the laboratory comprises a sample positioner comprising - suitable gripping means, - a video camera - image processing means.

 The gripping means, in the case of samples in the form of capsules are of the suction type and are mounted at the end of the robot.

 The video camera being placed above the work surface on which the sample is located, produces an image which is analyzed by the processing means. Thus the main axis of the sample is identified and appropriate orders are given to the robot by the control system to orient the main axis of the sample along a predetermined axis.

According to another characteristic of the invention, the samples on arrival at the laboratory for analysis and the containers used by the robot being provided with identifiers, the laboratory comprises - a manual reader of the identifiers of the samples
placed on the operator's work plan, - an automatic reading of the identifiers of the
containers used by the robot placed on the plan
robot work, - a supervision computer system.

 The supervision computer system is directly linked to the robot control system and the analyzers, and has access to a database which contains all the information necessary for the automatic execution of analyzes. In this same database can be stored the results of analyzes. This database can be single or distributed, installed on the supervision computer system or on another system on the same site or on a remote site.

 The samples to be analyzed are available in the airlock in conditioned form. The samples carry an identifier, for example, a bar code stuck on their packaging. This code is entered by the operator using the manual identifier reader located in the operator lock. The identifier of the container in which the operator has the sample to be analyzed is also entered manually. The results of these entries are transmitted to the computerized management system which combines them. Then, when the robot uses a new container to transfer all or part of the sample, it identifies this container by means of an automatic reader placed on its work surface and associates its identifier with that of the sample.

 Thus the computer system has knowledge of all the containers in which the sample has passed. In addition, he is aware of all the operations to which the sample was subjected, which ensures full traceability of the analyzes.

 In addition, if a sequence is interrupted, it is possible to resume it without risk of error.

Claims (18)

1- Robotic laboratory for sample analysis under  solid, liquid or pulverulent form, comprising a  plurality of analyzers (7, 11, 12 and 13) characterized in that  that it also includes a room (1) separated in two  contiguous non-communicating zones (2 and 3) for a  operating operator, one of said zones (2 and 3)  being called robotic zone and the other operator lock,  the robotic zone (2) comprising at least one robot (5)  industrial rotolde with at least five axes of work,  mounted on a horizontal displacement rail (6)  conferring an additional axis of work, provided with  means of movement on said rail (6) and provided at its  end of an industrial gripper (10), connected to a  control system, a work plan (4) of the robot (5)  supporting the analyzers (7,11,12 and 13), the airlock (3)  operator including a work plan for the operator  operating, two-way conveyors  transfer of containers containing the samples,  between the robotic zone (2) and the operator airlock (3). 2- Laboratory according to claim 1 characterized in that  that the rail (6) for moving the robot (5) has a  length greater than the length of the worktop  robot (5) so as to allow the robot (5) to access  two maintenance zones (14 and 15) located beyond  ends of said work plane (4). 3- Laboratory according to claim 1 or 2 characterized in  which it further includes, self-test means of the  repeatability of robot positioning (5) in  space according to its axes of work. 4- Laboratory according to claim 3 characterized in that  that the self-test means include at least one  fixed device chosen from microcontacts,  proximity sensors, laser detectors  suitably distributed in space and means  mobiles for activating said devices, carried by the  gripper (10) of the robot (5). 5- Laboratory according to any one of claims 1  to 4 characterized in that it further comprises at least  a rack (24) and containers (20) for samples,  mounted on supports (21), comprising  circular slots (22) for said supports  (21), said racks (24) and said supports (21)  being provided with angular positioning means of  each support (21) in a location (22). 6- Laboratory according to claim 5 characterized in that  that the angular positioning means comprise  a Hall effect sensor (21) attached to the rack (24) and a  magnet (25) secured to the support (21). 7- Laboratory according to claim 5 characterized in that  that the angular positioning means comprise  a video camera, image processing means and  means of angular location of each container  (20) in each location (22). 8- Laboratory according to any one of claims 1  to 7 characterized in that it further comprises a  automatic syringe dispenser (85)  cylindrical with eccentric tips (89), comprising a  support block (91) with shaped recesses (92)  suitable for housing the ends of the syringes (86) and  end pieces (89), a movable plate (88) provided with means  (96) for displacement and a position detector (97). 9- Laboratory according to any one of claims 1  to 8 characterized in that it further comprises a  accessory distributor (31) comprising two  vertical parallel flanges (33 and 34), plates  (35) superimposed, inclined, arranged in Z integral with the  flanges (33 and 34), flaps (36) articulated around the  upper edge (37) of each plate (35), mounted on  a horizontal base (38) rotating in two positions  stable shifted by 900 provided with means of rotation and  means (39, 40 and 42) of immobilization in both  stable positions, the lowest plate being provided  a vertical edge (43) for stopping the accessories (32)  allowing the taking of said accessories (32) by the  robot (5) in a single location. 10- Laboratory according to any one of claims 1  to 9 characterized in that it further comprises a  dimensional control station for a sample (46)  comprising a working block (47) comprising two holes  (48 and 49) coaxial conical with vertical axis (56),  upper and lower respectively, a slot (50)  horizontal separating the two conical holes (48 and 49),  a drawer (51) movable in the slot (50) closing the  lower part of the upper conical hole (48) provided with  means of movement in a horizontal plane, a bucket  (52) sample transfer (46), a bucket holder  (53) movable mounted on a horizontal slide (54),  placed below the working block (47), provided at its  upper part of a counterbore (55) for receiving the bucket  (52) centered in the axis (56) of the holes (48 and 49)  conical and comprising displacement means  horizontal, a video camera (57) placed above the  block (47) working in the axis (56) of the holes (48 and  49) conical and electronic processing means  of images. 11- Laboratory according to any one of claims 1  to 10 characterized in that it includes an adapter  universal grip consisting of a block (60)  cylindrical-conical comprising a cylindrical groove (63)  provided with two sectors (68) reception plans  industrial robot gripper (10). 12- Laboratory according to claim 10 characterized in that  that the universal grip adapter includes  in addition to a glass bottle stopper (64) fixed to  the end of its conical part (62). 13- Laboratory according to claim 10 characterized in that  that the universal grip adapter includes  in addition to an axial cylindrical recess intended to receive  a cannula (65). 14- Laboratory according to claim 10 characterized in that  that the universal grip adapter includes  in addition to two opposite axial frustoconical recesses for  mounting a tip (66) adapted to the shape and the  size of a tablet or capsule. 15- Laboratory according to any one of claims 1  to 14 characterized in that it comprises at least one  liquid distribution station comprising a frame  (70) fixed, at least one tube (72) of liquid to be distributed,  at least two receiving bottles (73 and 74), a support  (71) movable of tubes and bottles, provided with means  horizontal and vertical displacement, a syringe (75)  integral with the fixed frame (70) provided with a needle (76)  vertically mounted hollow connected to means (80)  suction and delivery means (81), one foot  crowbar (78) movable crossed by the needle (76), a  presser foot (78) return spring (77) in the  position away from the syringe (75), a stopper (79)  mechanical. 16- Laboratory according to any one of claims 1  to 15 characterized in that it includes a positioner  of sample comprising suitable means of  gripping of said sample, a video camera and  image processing means. 17- Laboratory according to any one of claims 1  to 16 characterized in that it includes a plug  bottle consisting of a first cylindrical block (101)  comprising a lateral groove (102) provided with two  sectors (103) gripper receiving plates (10)  industrial robot (5) and a second cylindrical block  coaxial diameter smaller than the diameter of the first  block and equal to the diameter of the stopper bottle. 18- Laboratory according to any one of claims 1  to 17 characterized in that, the samples and the  containers used by the robot (5) being provided  identifiers, it also includes a reader  manual of said identifiers placed in the airlock (3)  operator, an automatic reader of container identifiers placed on the work surface (4) of the robot (5), a computer supervision system connected to the robot control system (5, to the analyzers (7,11,12 and 13 ) said computer system having access to a database relating to the analysis procedures and to a database relating to the results of said analyzes.