CN116584880A - Optical multi-mode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe - Google Patents
Optical multi-mode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe Download PDFInfo
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- CN116584880A CN116584880A CN202310606905.2A CN202310606905A CN116584880A CN 116584880 A CN116584880 A CN 116584880A CN 202310606905 A CN202310606905 A CN 202310606905A CN 116584880 A CN116584880 A CN 116584880A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
Abstract
The invention provides an optical multi-mode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe. The optical multi-mode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe comprises a shell, a spectrum module, an ultrasonic module and a plurality of channels, wherein one end of the shell is provided with the spectrum module, the other end of the shell is provided with the plurality of channels extending to the inside, the side surface of the shell is concave, and the ultrasonic module is arranged; part of the channels are respectively connected with the spectrum module and the ultrasonic module, and the other part of the channels extend to the concave part of the side face of the shell and are internally provided with a first optical fiber and a second optical fiber or a biopsy needle. The optical multimode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe solves the problem of the optical multimode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe.
Description
Technical Field
The invention relates to the field of endoscopic probes, in particular to an optical multi-mode-based integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumors.
Background
Digestive system cancer is a major public health problem worldwide. Gastric cancer, colon cancer, rectal cancer, liver cancer, pancreatic cancer and esophageal cancer are highly prevalent, and are one of the main causes of cancer-related death in men and women in developed countries and developing countries. Traditional surgery, radiation therapy and chemotherapy are important means for treatment of digestive tract tumors, however, patients may have problems such as treatment failure, cancer recurrence and low postoperative quality of life after traditional treatment. Therefore, new therapeutic techniques are urgently needed in clinical practice to make up for the deficiencies of the conventional therapeutic techniques.
As a local targeting minimally invasive therapy for treating tumors, which is emerging in recent years, photodynamic therapy can provide patients with gentle, functional retention, safety, repeatability and effective treatment options due to the characteristics of safety, high efficiency, accuracy and the like. Photodynamic therapy is to irradiate a tissue with a laser of a specific wavelength to excite the photosensitizing agent absorbed by the tissue, and the excited photosensitizing agent in turn transfers energy to molecular oxygen in the surrounding tissue to generate active oxygen (a substantial part of which is singlet oxygen with strong activity), which undergoes an oxidation reaction with neighboring biological macromolecules to produce a cytotoxic effect, thereby killing tumor cells.
Although photodynamic therapy has shown good therapeutic effects on digestive tract malignant tumors in basic and clinical studies, it still has a great disadvantage in practical use. Good photosensitizer tumor accumulation, higher tumor oxygen partial pressure and sufficient intensity of illumination are three essential key elements for successful photodynamic therapy. However, in clinical application, a doctor usually determines the time required for tumor accumulation after photosensitizer injection through experience, and inserts an optical fiber for irradiation treatment after tumor positioning through an optical or ultrasonic endoscope, so that the three elements are not monitored, and the uncertainty of the treatment effect is caused. Furthermore, because the wall of the digestive tract is relatively thin, in the absence of monitoring and feedback control, photodynamic therapy may cause tissue necrosis throughout the wall thickness of the intestine at the treatment site. Finally, because the treatment parameters cannot be obtained in real time, the quantitative effect relation model in photodynamic therapy is difficult to establish, and the development of the photodynamic therapy regulation and control theory is restricted.
However, current digestive endoscopes are mostly based on ultrasound and wide-field optical imaging, both of which cannot effectively monitor critical parameters in the above-mentioned photodynamic. The wide-field optical endoscope is common digestive tract endoscopic equipment in clinic at present, and can perform high-definition real-time imaging on the surface of a digestive tract, so that a focus is rapidly positioned according to the characteristics of an optical image, but the detection result lacks depth information, and molecular functional imaging cannot be performed on photosensitizer and oxygen content. Ultrasound imaging exploits the difference in ultrasound reflectance of tumor tissue versus normal tissue, which can acquire complete structural information of the tumor and its surrounding tissue, but also does not have molecular functional imaging capabilities. Other conventional medical imaging methods such as positron emission tomography, computed tomography, magnetic resonance imaging, and the like are also very deficient in terms of photosensitizer and oxygen content imaging. Currently, there are only a few methods of using wide field fluorescence imaging to measure the photosensitizer content of tissue surfaces in photodynamic therapy. The oxygen content in the tissue is generally measured by a single-point measurement method such as a polarographic oxygen electrode, but the method cannot obtain accurate oxygen distribution in the whole tissue.
The photoacoustic imaging uses nanosecond pulse light as an excitation source, and images by detecting ultrasonic signals excited by tissue-specific light absorption, so that the limit of high-resolution optical imaging depth is broken through, and the photoacoustic imaging device has high tissue specificity of pure optical imaging and high penetration depth of ultrasonic imaging. Researchers propose a photoacoustic life imaging technology based on photosensitizer triplet state difference to eliminate strong background signal interference from blood and the like, realize specific dynamic imaging of photosensitizers and tissue oxygen, and obtain distribution of tissue oxygen partial pressure through triplet state life imaging of photosensitizers, so that clinical monitoring of photoacoustic life imaging on photodynamic therapy is possible.
Photoacoustic imaging requires a combination of endoscopic techniques to achieve detection of tumors within the digestive tract due to the relatively insufficient penetration depth of light in the human body. Currently, the mainstream photoacoustic endoscopic imaging generally adopts a laser/ultrasonic coaxial structure, the photoacoustic endoscope is simple and compact in structure, the probe is small in size, and a single high-performance ultrasonic transducer is adopted for high-quality imaging. However, such systems are mostly built based on highly repetitive single wavelength lasers of tens of kilohertz, but pulse energies typically less than 0.3 millijoules do not represent the high penetration advantage of photoacoustic imaging well. Photoacoustic endoscopic probes based on small medical ultrasound arrays are usually retrofitted with fiber optic bundles attached to both sides of such probes. However, existing photoacoustic endoscopes of this type are generally large in volume (typically about 2.5cm in diameter) and are generally limited to few studies such as rectal endoscopy and prostate cancer detection in humans or large animals.
Disclosure of Invention
The invention provides an integrated endoscopic probe based on optical multi-mode digestive tract tumor photodynamic diagnosis and treatment, which aims to solve the problems that the existing photoacoustic imaging equipment cannot embody the high penetration advantage of photoacoustic imaging or has larger volume.
An integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumor based on optical multi-mode comprises a shell, a spectrum module, an ultrasonic module and a plurality of channels, wherein one end of the shell is provided with the spectrum module, the other end of the shell is provided with the plurality of channels extending to the inside, the side surface of the shell is concave, and the ultrasonic module is arranged; part of the channels are respectively connected with the spectrum module and the ultrasonic module, and the other part of the channels extend to the concave part of the side face of the shell and are internally provided with a first optical fiber and a second optical fiber or a biopsy needle.
In a preferred embodiment of the optical multi-mode digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe provided by the invention, the shell is bullet-shaped, one end is pointed and provided with the spectrum module, and the other end is plane and provided with the channel. The diameter of the shell is 12.7mm, the length of the shell is 25mm, and the size of the spectrum module is 2mm x 0.5mm.
In a preferred embodiment of the optical multi-mode digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe provided by the invention, the side surface of the shell is provided with an arc-shaped recess, and the ultrasonic module is arranged along the arc-shaped inner wall of the recess.
The ultrasonic module is an ultrasonic array, the number of array units is 96, the center frequency is 10MHz, and the radius of the ultrasonic array is 10mm.
In a preferred embodiment of the integrated endoscopic probe for optical multi-mode tumor photodynamic diagnosis and treatment of digestive tract provided by the invention, the integrated endoscopic probe comprises five channels, wherein two channels are respectively connected with the spectrum module and the ultrasonic module, and the other three channels extend to the concave part of the side surface of the shell, wherein two channels respectively extend to two sides of the ultrasonic module, are respectively provided with the first optical fibers in the inner parts of the channels, and the other channels respectively extend to the upper parts of the ultrasonic module, and are internally provided with the second optical fibers or the biopsy needle.
The first optical fiber is a chamfer optical fiber, and the second optical fiber is an optical coherence tomography optical fiber or a light focusing photoacoustic endoscopic optical fiber.
In a preferred embodiment of the integrated endoscopic probe based on optical multi-mode digestive tract tumor photodynamic diagnosis and treatment, the first optical fiber transmits laser and makes the laser reflected at the top end of the optical fiber and laterally irradiate to a target body, and the ultrasonic module emits ultrasonic waves and irradiates to the target body; the ultrasonic module receives the photoacoustic signal.
The spectrum module is integrated with a micro spectrometer formed by a free-form super surface for spectrum recovery and real-time spectrum imaging. The second optical fiber transmits laser and enables the laser to be reflected at the top end of the optical fiber and to be irradiated to the target body laterally; the second optical fiber is incorporated into an optical coherence tomography system, or into a light focusing photoacoustic endoscopic system.
Compared with the prior art, the optical multi-mode digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe provided by the invention has the advantage that compared with the traditional endoscopic probe, the size is greatly reduced. Ultrasound imaging and photoacoustic imaging can be achieved, and high-speed photosensitizer concentration and tissue oxygen partial pressure imaging can be provided. The system has the functions of measuring related parameters of tissue layering, microvascular morphology and blood flow velocity, and has the capability of imaging a large-range spectrum in the cavity of the digestive tract in real time. The method can guide tumor positioning and tissue biopsy in deep tissues and accurate projection of photodynamic therapy light, and realizes cross-scale and cross-mode complete characterization of the photodynamic therapy of digestive tract tumors.
Drawings
FIG. 1 is a schematic structural view of an integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumors based on optical multi-mode;
FIG. 2 is a front view of an integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumors based on optical multi-modality;
FIG. 3 is a graph of simulated reconstruction results of an arcuate ultrasound array for point targets at different locations;
fig. 4 is a graph of lateral resolution of an arcuate ultrasound array at different depths.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention.
Referring to fig. 1 and fig. 2, the optical multi-mode digestive tract tumor photodynamic diagnosis and treatment integrated endoscope probe provided by the invention is a structural schematic diagram and a front view respectively.
The optical multimode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe comprises a shell 1, a spectrum module 2, an ultrasonic module 3 and five channels.
The shell 1 is bullet-shaped, has a diameter of 12.7mm and a length of 25mm. One end of the housing 1 is a tip and is provided with a spectrum module 2, and the size of the spectrum module 2 is 2mm x 0.5mm. The side of the shell 1 is provided with an arc-shaped recess, and an ultrasonic module 3 is arranged in the recess along the arc-shaped inner wall of the recess. The other end of the housing 1 is planar and provided with a channel.
Wherein two channels are respectively connected with the spectrum module 2 and the ultrasonic module 3, and provide power supply and data transmission functions. The other three channels extend to the concave part of the side surface of the shell 1, two of the three channels extend to two sides of the ultrasonic module 3 respectively, the inside of the ultrasonic module is provided with a first optical fiber 4 respectively, the other channel extends to the upper side of the ultrasonic module 3, and the inside of the ultrasonic module is provided with a second optical fiber 5.
The first optical fiber 4 is a chamfer optical fiber. Multimode angled optical fibers in both channels are used to transmit laser light into the lumen of the alimentary tract. The multimode chamfer optical fibers extend out from two channels positioned on two sides of the ultrasonic module 3, laser is directly reflected at the top end of the optical fibers, and focus positions are laterally irradiated.
Referring to fig. 3 and fig. 4, respectively, in the integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumor based on optical multi-mode provided by the invention, an ultrasonic module 3 is a simulation reconstruction result diagram of an arc-shaped ultrasonic array on point targets at different positions when ultrasonic imaging and photoacoustic imaging are performed; and a lateral resolution profile at different depths. As can be seen, the resolution of the array in this region is in the range of 150 μm to 300 μm, with high resolution.
The ultrasonic module 3 is an ultrasonic array, the number of array units is 96, the central frequency is 10MHz, and the radius of the ultrasonic array is 10mm. When ultrasonic imaging is carried out, firstly, ultrasonic waves are emitted by the ultrasonic array, after the ultrasonic waves are reflected by the target body, the ultrasonic waves are received by the ultrasonic array, and finally, image reconstruction is carried out by an ultrasonic reconstruction algorithm.
And performing photoacoustic imaging, namely irradiating laser onto a target body through a first optical fiber 4, receiving generated ultrasonic waves through an ultrasonic array, and finally performing image reconstruction through a photoacoustic reconstruction algorithm. The morphological structure of the tissue can be detected by ultrasonic imaging, and parameters such as blood oxygen and physiological functions of the deep tissue can be monitored in real time by a multi-wavelength photoacoustic imaging technology. High specificity photoacoustic lifetime imaging can provide high speed imaging of photosensitizer concentration with tissue oxygen partial pressure.
The second optical fiber 5 is an optical coherence tomography fiber and is incorporated into an optical coherence tomography system. The optical coherence tomography system mainly comprises a pulse laser, an ultrasonic excitation device, an optical fiber device and an ultrasonic motor miniature probe. Optical coherence tomography has the function of measuring tissue stratification, microvascular morphology and blood flow velocity related parameters.
The spectrum module 2 at the front end of the probe performs high-definition optics and hyperspectral imaging. The hyperspectral imaging is a method based on computational spectroscopy, uses a free-shaped hypersurface to perform spectrum sensing, can integrate a micro spectrometer formed by the free-shaped hypersurface in a limited area on a large scale, and realizes high-precision spectrum recovery and real-time spectrum imaging through a deep neural network acceleration algorithm. Hyperspectral imaging has the capability of imaging a large-range spectrum in the digestive tract cavity in real time.
These modalities can be used with ultrasound imaging to guide tumor localization in deep tissues, tissue biopsies, and precise projection of photodynamic therapy light. The probe integrates high-definition wide-field optical modes, high-spectrum modes and other modes, and realizes the integration with optical coherence tomography/light focusing photoacoustic endoscopic multi-mode endoscopic probes and other methods through surgical instrument channels and other methods, so that the cross-scale and cross-mode complete characterization of digestive tract tumor photodynamic therapy is realized.
These modalities can be used with ultrasound imaging to guide tumor localization in deep tissues, tissue biopsies, and precise projection of photodynamic therapy light. The probe integrates high-definition wide-field optical modes, high-spectrum modes and other modes, and realizes the integration with optical coherence tomography/light focusing photoacoustic endoscopic multi-mode endoscopic probes and other methods through surgical instrument channels and other methods, so that the cross-scale and cross-mode complete characterization of digestive tract tumor photodynamic therapy is realized.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes or direct or indirect application in other related arts are included in the scope of the present invention.
Claims (10)
1. An integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumor based on optical multi-mode is characterized in that: the ultrasonic device comprises a shell, a spectrum module, an ultrasonic module and a plurality of channels, wherein one end of the shell is provided with the spectrum module, the other end of the shell is provided with the channels extending to the inside, the side surface of the shell is concave, and the ultrasonic module is arranged; part of the channels are respectively connected with the spectrum module and the ultrasonic module, and the other part of the channels extend to the concave part of the side face of the shell and are internally provided with a first optical fiber and a second optical fiber or a biopsy needle.
2. The integrated optical multi-mode digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 1, wherein: the shell is warhead-shaped, one end is pointed and provided with the spectrum module, and the other end is plane and provided with the channel.
3. The integrated optical multi-modal-based digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 2, wherein: the diameter of the shell is 12.7mm, the length of the shell is 25mm, and the size of the spectrum module is 2mm x 0.5mm.
4. The integrated optical multi-modal-based digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 2, wherein: the side of shell is provided with the sunken of arc to be equipped with along sunken arc inner wall therein the ultrasonic module.
5. The integrated optical multi-mode digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 4, wherein: the ultrasonic module is an ultrasonic array, the number of array units is 96, the center frequency is 10MHz, and the radius of the ultrasonic array is 10mm.
6. The integrated optical multi-modal-based digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 2, wherein: the ultrasonic detection device comprises five channels, wherein two channels are respectively connected with the spectrum module and the ultrasonic module, the other three channels extend to the concave parts of the side face of the shell, two channels respectively extend to two sides of the ultrasonic module, the first optical fibers are respectively arranged in the channels, the other channels respectively extend to the upper part of the ultrasonic module, and the second optical fibers or the biopsy needle are respectively arranged in the channels.
7. The integrated optical multi-mode digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 6, wherein: the first optical fiber is a chamfer optical fiber, and the second optical fiber is an optical coherence tomography optical fiber or a light focusing photoacoustic endoscopic optical fiber.
8. The optical multi-mode-based integrated endoscopic probe for photodynamic diagnosis and treatment of digestive tract tumors according to claim 1-6 and Tan Yi, wherein the optical multi-mode-based integrated endoscopic probe is characterized in that: the first optical fiber transmits laser and enables the laser to be reflected at the top end of the optical fiber and to be irradiated to the target body in a lateral direction, and the ultrasonic module emits ultrasonic waves and irradiates to the target body; the ultrasonic module receives the photoacoustic signal.
9. The integrated optical multi-mode digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 8, wherein: the spectrum module is integrated with a micro spectrometer formed by a free-form super surface for spectrum recovery and real-time spectrum imaging.
10. The integrated optical multi-modal-based digestive tract tumor photodynamic diagnosis and treatment endoscopic probe according to claim 9, wherein: the second optical fiber transmits laser and enables the laser to be reflected at the top end of the optical fiber and to be irradiated to the target body laterally; the second optical fiber is incorporated into an optical coherence tomography system, or into a light focusing photoacoustic endoscopic system.
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| CN202310606905.2A CN116584880A (en) | 2023-05-26 | 2023-05-26 | Optical multi-mode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe |
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| CN202310606905.2A CN116584880A (en) | 2023-05-26 | 2023-05-26 | Optical multi-mode-based digestive tract tumor photodynamic diagnosis and treatment integrated endoscopic probe |
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