CN105816155B - A kind of skin wound diagnosis and treatment integrated probe and its implementation - Google Patents
A kind of skin wound diagnosis and treatment integrated probe and its implementation Download PDFInfo
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- CN105816155B CN105816155B CN201610319398.4A CN201610319398A CN105816155B CN 105816155 B CN105816155 B CN 105816155B CN 201610319398 A CN201610319398 A CN 201610319398A CN 105816155 B CN105816155 B CN 105816155B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0064—Body surface scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
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Abstract
The present invention relates to a kind of skin wound diagnosis and treatment integrated probe and its implementation, including a ring-shaped LED array, carry out skin wound treatment to generate equally distributed illumination；One is set to the diagnostic probe at the center of the ring-shaped LED array, to generate ultra-short pulse laser wavelength go forward side by side row information acquisition realize skin wound diagnosis；And one be set to telescopic sleeve set on the shell of diagnostic probe, to adjust disconnected probe between the surface of a wound at a distance from；Ring-shaped LED array includes a plurality of LED light parallel with one another, the LED light is the red, green, blue three-color LED light of common-anode, the three-color LED light is connected with three groups of switches and potentiometer, respectively to control three kinds of wavelength LED light intensities of red, green, blue, the illumination to produce different wave length and intensity carries out skin wound treatment for three groups of switches and potentiometer.The present invention organically combines diagnosing and treating dual function, can be improved the validity and accuracy for the treatment of, realizes personalized precisely treatment.
Description
Technical field
The present invention relates to skin diagnosis therapy fields, more particularly to a kind of skin wound diagnosis and treatment integrated probe and in fact
Existing method.
Background technique
Skin is the important protective barrier of human body, and is the important component of body immune system, be human body area most
Big organ.Skin continuity caused by any reasons such as operation, scald, burn, incised wound is destroyed and Deletional damage, if
It is closed not in time, easily the acute and chronic infection of the generation surface of a wound and its corresponding complication, and may cause pathologic scar
Generation.Therefore, it is always that doctor and patient are closed jointly that the quick healing of skin wound and the perfect of structure and function, which are repaired,
The problem of heart.LED light has been shown to have Photobiomodulation, can accelerate the metabolism of irradiated site cell, promotes blood
Liquid circulation, accelerates tissue trauma repair process.It has been favourably utilised for treatment chronic ulcer of skin etc..LED illumination creates skin
The treatment repair in face depend on the optical parameters such as optical wavelength, flow, intensity, irradiation time, continuous wave or impulse wave and
Treatment number of times clinically, treatment interval.Different lightwave grows the difference of the penetration capacity in skin histology, and usual wavelength is longer
Penetration depth is deeper；Meanwhile the light of different wave length can be absorbed by different color bases in tissue, realize different therapeutic purposes and
Effect.For example, clinically feux rouges (630nm~700nm) can penetrate the skin histology that skin histology reaches deep layer, it is usually used in treating
Disease of sebaceous glands etc..Meanwhile the wavelength of 660nm can improve the microcirculation of the hematological system and lymphatic system of skin, stimulate cell
Interior mitochondria activity, and it can reach the lamina reticularis of dermis of skin and make to play the skin fibroblasts in corium
With stimulation generates collagen, accelerates wound repair.Blue light (400nm~470nm) penetration capacity is weaker, is usually used in treating position
In the skin lesion of epidermis, still, 470nm blue light has apparent bactericidal effect, and can promote revascularization and tissue repair.In addition,
After 595nm yellow light skin, has and accelerate blood circulation, activating cell stimulates the active effect of cell excitability, and promotes
Collagen synthesis.Multi-wavelength's LED light combination irradiation generates different therapeutic effects to skin wound, also just studied application
To promote the more preferable reparation of the surface of a wound.
Meanwhile skin wound reparation is a various kinds of cell and the complex process that cytoplasm participates in jointly.All ages and classes
The ability of its skin wound reparation of the patient of different physical conditions is not quite similar.If can be supervised in time in LED illumination therapeutic process
The state change for surveying cell and cytoplasm in skin epidermis and corium can adjust the light such as wavelength and the power for the treatment of light in time
Parameter is learned to advantageously promote the quick and perfect reparation of skin wound.Develop rapidly in recent years based on tissue it is inherent at
The nonlinear optics imaged skin mirror of the two-photon fluorescence excitation and second harmonic signal that divide can perform well in non-destructive monitoring
Skin injury reparation.Keratin in skin epidermis and hair follicle, in the flavoprotein, NAD (P) H and skin corium in cell
Elastic fibers etc. can generate self fluorescence signal, the collagen with non-centrosymmetric structure in skin corium by multiphoton excitation
Albumen etc. can generate second harmonic signal, by these in skin histology in the autofluorescence of ingredient or harmonic signal
Acquisition and imaging simultaneously can carry out lossless diagnosis and monitoring to skin histology under without additional compounds probe conditions.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of skin wound diagnosis and treatment integrated probe and its implementation, base
In nonlinear optics imaging and LED array light exposure treatment, diagnosing and treating dual function is organically combined, is realized real-time
Monitoring and in time adjustment LED light wavelength, photoradiation treatment dosage etc., improve the validity and accuracy for the treatment of, realize personalized
Precisely treatment.
The present invention is realized using following scheme: a kind of skin wound diagnosis and treatment integrated probe, including a ring-shaped LED array,
Skin wound treatment is carried out to generate equally distributed illumination；One diagnosis for being set to the center of the ring-shaped LED array is visited
Head, to generate ultra-short pulse laser wavelength go forward side by side row information acquisition realize skin wound diagnosis；And one be set to described examine
Telescopic sleeve set on the shell of disconnected probe, to adjust the diagnostic probe between the surface of a wound at a distance from；The annular LED battle array
Column include a plurality of LED light parallel with one another, and the LED light is the red, green, blue three-color LED light of common-anode, three color
LED light is connected with three groups of switches and potentiometer, and three groups of switches and potentiometer are respectively to control three kinds of wavelength of red, green, blue
LED light intensity, the illumination to produce different wave length and intensity carry out skin wound treatment.
Further, in three groups of switches and potentiometer, switch and potentiometer in every group are serially connected, and every group
Switch and potentiometer are connected with an ammeter, for measuring the driving current of LED light.
It further, further include a D.C. regulated power supply, the D.C. regulated power supply is connected with the ring-shaped LED array,
To power.
Further, the quantity of the three-color LED light in the ring-shaped LED array is no less than 8, can preferably generate uniformly
Illumination and enough luminous intensities are used for Wound treating.
Further, plural number LED light parallel with one another equidistantly lines up the ring-shaped LED array that radius is r, according to examining
The direct distance z of the light source and the illuminated surface of a wound that disconnected probe issues, calculates the radius r of ring-shaped LED array0:
The light emitting angle of each LED light is θ, and each LED light is distributed as by force lambertian distribution, then ring-shaped LED array is in space
In Illumination Distribution E meet:
Wherein, I is the intensity of illumination of each LED light, and m value depends on the light emitting region of LED light and the curvature of package lens
Relationship between the distance between center, with light emitting angle θ are as follows:
By adjusting the radius r of ring-shaped LED array, so thatWhen, then the radius is r0Annular LED
The illumination that array generates is uniform on the surface of a wound for being z with light source vertical range.
Further, the diagnosis and treatment integrated probe further includes a diagnosis and treatment integrated probe shell, the diagnosis and treatment integration
Probing shell is a cylindrical shell, and the ring-shaped LED array is set to an end face of the cylindrical shell, and the diagnosis is visited
Head and the telescopic sleeve set being set on the shell of the diagnostic probe are all set in the inside of the cylindrical shell.
Further, diagnostic probe non-linear optical endoscope probe, including doubly clad optical fiber, miniature object lens and
Tubular piezo-electric driver, the miniature object lens are connected with the tubular piezo-electric driver by the doubly clad optical fiber.
The present invention also uses following methods to realize: a kind of implementation method of skin wound diagnosis and treatment integrated probe, including with
Lower step:
Step S1: the diagnostic probe stretches out the telescopic sleeve set, issues ultrashort pulse exciting light, the ultrashort pulse
Exciting light is transferred to miniature object lens by the fibre core of the doubly clad optical fiber in the diagnostic probe and focuses on skin wound, skin wound
Face is excited the endogenous signal that generates after light excitation；
Step S2: the miniature object lens collect endogenous signal, the inner cladding through doubly clad optical fiber be transferred to detector into
Row signal acquisition and imaging, doubly clad optical fiber, which is bonded in tubular piezo-electric driver, drives optical fiber cantilever to realize to skin wound
Two-dimensional scanning；
Step S3: the diagnostic probe retracts the telescopic sleeve set, adjusts three groups of switches and potentiometer control
The intensity of the red, green, blue tricolor LED light, is combined into the light of different wave length varying strength, to realize to the different surface of a wound most
Optimization treatment.
Further, the ultra-short pulse laser wavelength is the near infrared light of 810nm, to excite skin histology endogenous
It is harmonious to collect the auto flourescence signals including auto flourescence signals and harmonic signal from cell and cytoplasm for signal
Wave signal realizes the lossless visible diagnosis to skin histology epidermis and skin corium for being imaged.
Further, in the step S3, before being treated using the three-color LED light, the diagnostic probe retraction is set
It is placed in the telescopic sleeve set on the shell of the diagnostic probe, avoids influencing being uniformly distributed for treatment light, realize to diagnosis
Probe adjustably adjusts.
Particularly, in the step S1, when being diagnosed using diagnostic probe, the diagnostic probe stretch out close to the surface of a wound into
Row can start switch mode by being arranged in body noninvasive imaging automatically, real-time diagnosis monitoring disease during treatment
The reparation situation of individual human skin wound, the parameters such as dosage of the light of adjustment treatment in time, realizes personalized accurate treatment.
Compared with prior art, the present invention has the advantage that (1) dexterously designs ring-shaped LED array, uniform light is generated
While according to the facts showing the light exposure treatment to tissues such as skins, placed using the vacancy at ring-shaped LED array center diagnostic micro-
Type probe；(2) diagnostic light is realized by external switch and treats being respectively started for light, do not interfere with each other.It simultaneously will be diagnostic
Miniature probe is mounted in an extension sleeve, with facilitate diagnosis when by diagnostic probe stretch out close to be diagnosed tissue carry out at
Picture, and diagnostic probe is retracted in treatment and is distributed without the uniform light field for influencing treatment light；(3) by adjusting tricolor LED light
Intensity is realized to for the LED light wavelength for the treatment of and the adjusting of dosage；(4) integration of diagnosing and treating can pass through setting
Automatic starting switch mode passes through diagnostic monitoring individual patient situation, the dosage of the light of adjustment treatment in time during treatment
Etc. parameters, realize personalized accurate treatment.
Detailed description of the invention
Fig. 1 is the schematic perspective view of diagnosis and treatment integrated probe in the present invention.
In figure: 11 be ring-shaped LED array, and 12 be diagnostic probe, and 13 be telescopic sleeve, and 14 is outside diagnosis and treatment integrated probes
Shell.
Fig. 2 is the front of diagnosis and treatment integrated probe and designed ring-shaped LED array light exposure treatment head knot in the present invention
Structure schematic diagram.
21 ring-shaped LED array constituted for red, green, blue three-color LED light in figure, 22 be diagnostic probe, and 23 be scalable set
Cylinder, 24 be diagnosis and treatment integrated probe shell, and 25 be D.C. regulated power supply, and 26 be switch, and 27 be potentiometer, and 28 be ammeter.
Fig. 3 is the side cross-section structure of diagnosis and treatment integrated probe in the present invention and the structural schematic diagram of built-in diagnostic probe.
31 be doubly clad optical fiber, and 32 be miniature object lens, and 33 be tubular piezo-electric driver, and 34 be the shell of diagnostic probe, and 35 be scalable
Sleeve, 36 be diagnosis and treatment integrated probe shell.
Specific embodiment
The present invention will be further described with reference to the accompanying drawings and embodiments.
The present embodiment provides a kind of skin wound diagnosis and treatment integrated probes, including a ring-shaped LED array, to generate uniformly
The illumination of distribution carries out skin wound treatment；One is set to the diagnostic probe at the center of the ring-shaped LED array, super to generate
Short-pulse laser wavelength go forward side by side row information acquisition realize skin wound diagnosis；And one be set on the shell of the diagnostic probe
Telescopic sleeve set, to adjust the diagnostic probe between the surface of a wound at a distance from；The ring-shaped LED array includes a plurality of phases
Mutually LED light in parallel, the LED light is the red, green, blue three-color LED light of common-anode, the three-color LED light and three groups of switches
It is connected with potentiometer, three groups of switches and potentiometer are respectively to control three kinds of wavelength LED light intensities of red, green, blue, to produce
The illumination for bearing different wave length and intensity carries out skin wound treatment.
In the present embodiment, as shown in Figure 1, the diagnosis and treatment integrated probe is mainly made of two parts: first is that design ring
Shape LED array 11 is for generating equally distributed illumination for Wound treating；Second is that the center location in ring-shaped LED array is placed
Diagnostic diagnostic probe 12, the diagnostic probe 12 are sleeved on a telescopic set bucket 13 and realize to diagnostic probe and wound
The adjusting of distance between the surface.
In the present embodiment, the quantity of the three-color LED light in the ring-shaped LED array is no less than 8, can preferably generate
Uniform illumination and enough luminous intensities are used for Wound treating.
In the present embodiment, as shown in Fig. 2, each LED for constituting ring-shaped LED array 21 is the red, green, blue of common-anode
Three-color LED composition, powers to it using D.C. regulated power supply 25, and controls red, green, blue using three groups of switches 26 and potentiometer 27
The luminous intensity of three kinds of primary lights, so that combination produces treatment of the illumination of different wave length and intensity for skin wound, electricity
Flow table 28 is used to measure and show the driving current of LED.It is r's that plural number LED light parallel with one another, which equidistantly lines up radius,
Ring-shaped LED array 21, parallel connection welding is on circuit boards.It is needed by practical application, the light source and quilt issued according to diagnostic probe 22
The surface of a wound directly distance z is irradiated, the radius r of ring-shaped LED array is calculated0:
The light emitting angle of each LED light is θ, and each LED light is distributed as by force lambertian distribution, then ring-shaped LED array is in space
In Illumination Distribution E meet:
Wherein, I is the intensity of illumination of each LED light, and m value depends on the light emitting region of LED light and the curvature of package lens
Relationship between the distance between center, with light emitting angle θ are as follows:
By adjusting the radius r of ring-shaped LED array, so thatWhen, then the radius is r0Annular LED
The illumination that array generates is uniform on the surface of a wound for being z with light source vertical range.
In the present embodiment, the diagnosis and treatment integrated probe further includes a diagnosis and treatment integrated probe shell, the diagnosis and treatment one
Body probing shell is a cylindrical shell, and the ring-shaped LED array is set to an end face of the cylindrical shell, described to examine
Disconnected probe and the telescopic sleeve set being set on the shell of the diagnostic probe are all set in the interior of the cylindrical shell
Portion.
In the present embodiment, as shown in figure 3, the diagnostic probe non-linear optical endoscope is popped one's head in, including double clad light
31 fine, miniature object lens 32 and tubular piezo-electric driver 33, the miniature object lens and the tubular piezo-electric driver pass through described
Doubly clad optical fiber is connected.
In the present embodiment, a kind of implementation method of skin wound diagnosis and treatment integrated probe, comprising the following steps:
Step S1: the diagnostic probe stretches out the telescopic sleeve set, issues ultrashort pulse exciting light, the ultrashort pulse
Exciting light is transferred to miniature object lens 32 by the fibre core of the doubly clad optical fiber 31 in the diagnostic probe and focuses on skin wound, skin
The skin surface of a wound is excited the endogenous signal that generates after light excitation；
Step S2: the miniature object lens 32 collect endogenous signal, and the inner cladding through doubly clad optical fiber is transferred to detector
Signal acquisition and imaging are carried out, doubly clad optical fiber, which is bonded in tubular piezo-electric driver 33, drives optical fiber cantilever to realize to skin
The two-dimensional scanning of the surface of a wound；
Step S3: the diagnostic probe retracts the telescopic sleeve set, adjusts three groups of switches and potentiometer control
The intensity of the red, green, blue tricolor LED light, is combined into the light of different wave length varying strength, to realize to the different surface of a wound most
Optimization treatment.
In the present embodiment, the ultra-short pulse laser wavelength is the near infrared light of 810nm, to excite in skin histology
Property signal in source collects the auto flourescence signals including auto flourescence signals and harmonic signal from cell and cytoplasm
With harmonic signal for being imaged, the lossless visible diagnosis to skin histology epidermis and skin corium is realized.
In the present embodiment, in the step S3, before being treated using the three-color LED light, the diagnostic probe contracting
It returns in the telescopic sleeve set 35 being set on the shell 34 of the diagnostic probe, avoids influencing being uniformly distributed for treatment light, it is real
Now diagnostic probe is adjustably adjusted.
Particularly, in the step S1, when being diagnosed using diagnostic probe, the diagnostic probe stretch out close to the surface of a wound into
Row can start switch mode by being arranged in body noninvasive imaging automatically, real-time diagnosis monitoring disease during treatment
The reparation situation of individual human skin wound, the parameters such as dosage of the light of adjustment treatment in time, realizes personalized accurate treatment.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification, is all covered by the present invention.
Claims (6)
1. a kind of skin wound diagnosis and treatment integrated probe, it is characterised in that: including a ring-shaped LED array, uniformly divide to generate
The illumination of cloth carries out skin wound treatment；One is set to the diagnostic probe at the center of the ring-shaped LED array, ultrashort to generate
Pulse laser wavelength go forward side by side row information acquisition realize skin wound diagnosis；And one be set on the shell of the diagnostic probe
Telescopic sleeve, to adjust the diagnostic probe between the surface of a wound at a distance from；The ring-shaped LED array include it is a plurality of mutually simultaneously
The LED light of connection, the LED light are the red, green, blue three-color LED light of common-anode, the three-color LED light and three groups of switches and electricity
Position device is connected, and three groups of switches and potentiometer are respectively to control three kinds of wavelength LED light intensities of red, green, blue, to produce
The illumination of different wave length and intensity carries out skin wound treatment.
2. a kind of skin wound diagnosis and treatment integrated probe according to claim 1, it is characterised in that: three groups of switches and
In potentiometer, switch and potentiometer in every group are serially connected, and every group of switch and potentiometer are connected with an ammeter, are used
To measure the driving current of LED light.
3. a kind of skin wound diagnosis and treatment integrated probe according to claim 1, it is characterised in that: further include that a direct current is steady
Voltage source, the D.C. regulated power supply is connected with the ring-shaped LED array, to power.
4. a kind of skin wound diagnosis and treatment integrated probe according to claim 1, it is characterised in that: the annular LED battle array
The quantity of three-color LED light in column is no less than 8.
5. a kind of skin wound diagnosis and treatment integrated probe according to claim 1, it is characterised in that: further include a diagnosis and treatment one
Body probing shell, the diagnosis and treatment integrated probe shell are a cylindrical shell, and the ring-shaped LED array is set to the circle
One end face of cylindrical outer cover, the diagnostic probe and the telescopic sleeve being set on the shell of the diagnostic probe are respectively provided with
In the inside of the cylindrical shell.
6. a kind of skin wound diagnosis and treatment integrated probe according to claim 1, it is characterised in that: the diagnostic probe is
Non-linear optical endoscope probe, including doubly clad optical fiber, miniature object lens and tubular piezo-electric driver, the miniature object lens with
The tubular piezo-electric driver is connected by the doubly clad optical fiber.
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| CN201610319398.4A CN105816155B (en) | 2016-05-13 | 2016-05-13 | A kind of skin wound diagnosis and treatment integrated probe and its implementation |
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| JP6859557B2 (en) * | 2018-03-22 | 2021-04-14 | ソニア・セラピューティクス株式会社 | Treatment device |
| CN109758122B (en) * | 2019-03-04 | 2021-10-01 | 上海长海医院 | Burn wound detection and recording system based on skin mirror |
| CN109752841A (en) * | 2019-03-26 | 2019-05-14 | 成都理想境界科技有限公司 | Fibre optic scanner and projection display apparatus, endoscopic apparatus |
| CN109799609B (en) * | 2019-03-26 | 2022-05-17 | 成都理想境界科技有限公司 | Optical fiber scanner and projection equipment |
| CN114010163B (en) * | 2021-12-02 | 2023-12-19 | 中国中医科学院医学实验中心 | Epidermis cell migration positioning system and method based on optical imaging |
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