CN105232193A - Pulmonary artery stent - Google Patents
Pulmonary artery stent Download PDFInfo
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- CN105232193A CN105232193A CN201510520649.0A CN201510520649A CN105232193A CN 105232193 A CN105232193 A CN 105232193A CN 201510520649 A CN201510520649 A CN 201510520649A CN 105232193 A CN105232193 A CN 105232193A
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- coating
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- lung arterial
- arterial support
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Abstract
The invention discloses a pulmonary artery stent. The stent is a cylindrical barrel consisting of a screen mesh, threads of the screen mesh are composite threads, bodies of the composite threads are made of plastic degradable materials, and a coating coats the body of each composite thread; and each coating is divided into a bottom layer and an outer layer, each bottom layer is a compact and non-degradable metal coating, and each outer layer is a polymer layer. The bodies of the composite threads have good plasticity, and can be subjected to post-dilatation repeatedly, so that the stent can adapt to an anatomical structure of a pulmonary artery, the coatings stop the bodies of the composite threads from being in contact with blood, and the degradation velocity of the stent can be reduced greatly. After the stent is subjected to post-dilation repeatedly and is dilated to a certain limitation degree, the coatings of the surface of the stent have cracks and injury, then the bodies of the composite threads are in contact with the blood of a patient, and the bodies of the composite threads can be degraded gradually.
Description
Technical field
The invention belongs to medical instruments field, relate to arterial bracket technology specifically, the lung arterial support that particularly a kind of degradation speed is controlled.
Background technology
Stenosis of pulmonary artery is a kind of common disease in congenital heart disease field, and Therapeutic Method comprises surgical operation and interventional therapy, wherein surgical operation therapy stenosis of pulmonary artery because of its wound large, mortality rate is high and limited.Interventional therapy comprises balloon angioplasty and Stent, wherein its half patient's blood vessel bore of balloon dilatation can improve, but its restenosis incidence rate is high, and endovascular stent implantation can significantly improve success rate, restenosis rate is low and patient suffering is less, has become the method for first-selected treatment stenosis of pulmonary artery.
Because stenosis of pulmonary artery patient age is little, and also increase gradually with patient age increase pulmonary artery size, and when growing up, blood vessel size is stablized.Therefore desirable lung arterial support require its can after expand, and expansible diameter range meets the requirement of each age group individual with pulmonary size, requires that support can be degraded after patient grows up simultaneously.But, special lung arterial support is had no at home and abroad at present clinical, all use and substitute support, as the support etc. using indication to be aortic stenosis or biliary tract stenosis, because of aorta or biliary tract different from Pulmonic anatomical structure, so class substitutes support cannot adapt to Pulmonic anatomical structure completely, and substitute support all adopt traditional non-degradable material, for permanent implanted, therefore in the urgent need to a kind of special degradable lung arterial support.
In addition, its subject matter existed of current degradable support is that degradation rate is too fast, and degradation rate is uncontrollable, as namely magnesium alloy blood vessel rack starts degraded after the implantation, namely degradable implantation about 3 months.And lung arterial support to require after stenter to implant that the time of survival is longer, at least should be several years even more than ten years, be applicable to pulmonary artery anatomical structure completely in the urgent need to one therefore at present, and the lung arterial support that degradation rate is controlled.
Summary of the invention
The object of this invention is to provide a kind of support being used for the treatment of stenosis of pulmonary artery, after this stenter to implant can after expand, outside the Pulmonic anatomical structure of deconditioning, when after patient grows up, blood vessel size is stablized, support can start degraded, to reduce the incidence rate of concurrent inflammation and thrombosis as far as possible.
The invention provides a kind of lung arterial support, described support is the cylindrical tube be made up of silk screen, and the silk forming described silk screen is composite filament, and the body of described composite filament is plastic degradation material, the outside applying coating of described body; Wherein, described coating is divided into bottom and skin, and bottom is fine and close nondegradable metal coating, and skin is polymeric layer.
The body of composite filament adopts degradation material, and has good plasticity, can complete and repeatedly expand afterwards, adapt to Pulmonic anatomical structure.
Coating intercepts body and the contacting blood of composite filament, and can greatly delay scaffold degradation speed, stent-expansion, to certain extreme degree, can cause the crackle of face coat, damage, and the bulk material of composite filament and contacting blood can be degraded gradually.
Preferably, the bulk material of composite filament can be at least one of the materials such as magnesium alloy, polylactic acid (PLLA), polyglycolic acid (PGA), poly (glycolide-lactide) (PLGA), polycaprolactone (PCL).
Preferably, the body of described composite filament is prepared from by cut, braiding or 3 dimension printing techniques.
Preferably, the bottom of described coating is gold or ferrum.
Preferably, described coating skin is polylactic acid (PLLA), polyglycolic acid (PGA), poly (glycolide-lactide) (PLGA), polyvinyl alcohol (PVA), at least one in the materials such as polycaprolactone (PCL).
Preferably, described bottom is applied on the body by plating or electrostatic spraying.
Preferably, the skin of described coating is coated on described bottom by least one in magnetron sputtering method, spin-coating method, electrostatic spray, ultrasonic spraying process or infusion process.
Preferably, the skin of described coating contains antithrombotic reagent and/or promotes the somatomedin of endothelialization.
Preferably, described silk screen is the net of corrugated silk formation from beginning to end, thus forms described cylindrical tube.
Preferably, to be multiple corrugated silk along the axis direction of described cylindrical tube be arranged in order described silk screen is interconnected and the net formed from beginning to end separately, thus form described cylindrical tube.
When support to complete repeatedly expansion and after stent-expansion to certain extreme degree, crackle, damage appear in the face coat of the composite filament of support, cause bulk material and the contacting blood of composite filament, the body of composite filament can be degraded gradually.
Accompanying drawing explanation
Fig. 1 is the body of the composite filament of lung arterial support in the embodiment of the present invention and the structural representation of coating.
Fig. 2 is the deployed configuration schematic diagram of the cylindrical tube of lung arterial support of the present invention.
Detailed description of the invention
For making object of the present invention, technical scheme and advantage clearly understand, referring to accompanying drawing, the present invention is described in more detail.
Lung arterial support in the present invention is the cylindrical tube be made up of silk screen, and the silk forming described silk screen is composite filament, and the body of described composite filament is plastic degradation material, the outside applying coating of described body; Wherein, described coating is divided into bottom and skin, and bottom is fine and close nondegradable metal coating, and skin is polymeric layer.Be illustrated in figure 1 the cross section of the silk that support uses, the body 10 of composite filament adopts degradation material, such as, can be at least one of the materials such as magnesium alloy, polylactic acid (PLLA), polyglycolic acid (PGA), poly (glycolide-lactide) (PLGA), polycaprolactone (PCL).At body outer surface applying coating.The coating of body 10 outer surface of composite filament is divided into bottom 201 and outer 202.Bottom 201 is fine and close nondegradable metal coating, such as, and the materials such as gold or ferrum; Outer 202 is polymeric layer, such as, at least one in the materials such as polylactic acid (PLLA), polyglycolic acid (PGA), poly (glycolide-lactide) (PLGA), polyethylene alkyd (PVA), polycaprolactone (PCL).Coating intercepts body 10 and the contacting blood of composite filament, greatly can delay the degradation speed of the body 10 of composite filament.Stent-expansion, to certain extreme degree, can cause the crackle of face coat, damage, and the bulk material of composite filament and contacting blood can be degraded gradually.
The body of composite filament adopts degradation material, and has good plasticity, can complete and repeatedly expand afterwards, adapt to Pulmonic anatomical structure.
The body of described composite filament can be formed netted by the various known mode that obtains, such as, be prepared from by cut, braiding or 3 dimension printing techniques.
Described bottom can be applied on the body by plating or electrostatic spraying.
Then, the skin of described coating can be coated on described bottom by least one in magnetron sputtering method, spin-coating method, electrostatic spray, ultrasonic spraying process or infusion process.
The skin of described coating can containing antithrombotic reagent and/or the somatomedin promoting endothelialization.
Described silk screen is the net of corrugated silk formation from beginning to end, thus forms described cylindrical tube.
Adapt to the demand of different length, described silk screen for multiple corrugated silk is arranged in order along the axis direction of described cylindrical tube and be interconnected and from beginning to end separately and net that is that formed, thus can form described cylindrical tube.Such waveform silk screen, is conducive to after support is inserted human body, carries out repeatedly larger expansion, namely expands afterwards, to adapt to patient the increasing of tremulous pulse with age.Certainly, silk screen is not limited to corrugated silk screen, any shape that can have larger degrees of expansion in rear expansion can, the silk screen etc. of such as fold shape.
When support to complete repeatedly expansion and after stent-expansion to certain extreme degree, crackle, damage appear in the face coat of the composite filament of support, cause bulk material and the contacting blood of composite filament, the body of composite filament can be degraded gradually.
Fig. 2 is the schematic diagram after cutting off along the axis direction of the cylinder of support, and axis direction is horizontal direction.The cylindrical shape that silk by Fig. 2 docks formation is up and down support of the present invention.After inserting human body, sacculus can be used to expand, and along with the growth of patient age, can repeatedly expand, to adapt to the growth of patient's tremulous pulse.This is the known approaches of those skilled in the art, repeats no more.
Embodiment
See Fig. 1 and Fig. 2, in the present embodiment, lung arterial support is the cylindrical tube be made up of silk screen, the silk forming described silk screen is composite filament, wherein the body 10 of composite filament adopts magnesium base alloy, at the body 10 outer surface coating bottom 201 of composite filament, this primer selects gold, and at coating bottom 201 outer surface coating skin 202, this cladding material selects polylactic acid (PLLA).
In the present embodiment, the silk screen of the body 10 of composite filament adopts laser cutting parameter preparation, and the shape of described silk screen is that multiple corrugated silk is arranged in order from left to right, and they are interconnected each other by silk, and each waveform silk is from beginning to end and define cylindrical tube.
Claims (10)
1. a lung arterial support, described support is the cylindrical tube be made up of silk screen, it is characterized in that, the silk forming described silk screen is composite filament, and the body of described composite filament is plastic degradation material, the outside applying coating of described body;
Wherein, described coating is divided into bottom and skin, and bottom is fine and close nondegradable metal coating, and skin is polymeric layer.
2. lung arterial support as claimed in claim 1, it is characterized in that, the bulk material of composite filament is at least one of magnesium alloy, polylactic acid, polyglycolic acid, poly (glycolide-lactide), polycaprolactone material.
3. lung arterial support as claimed in claim 1, is characterized in that, the body of described composite filament is prepared from by cut, braiding or 3 dimension printing techniques.
4. lung arterial support as claimed in claim 1, is characterized in that, the bottom of described coating is gold or ferrum.
5. lung arterial support as claimed in claim 1, it is characterized in that, the skin of described coating is polylactic acid, polyglycolic acid, polyvinyl alcohol, poly (glycolide-lactide), at least one in polycaprolactone material.
6. lung arterial support as claimed in claim 1, is characterized in that, described bottom is applied on the body by plating or electrostatic spraying.
7. lung arterial support as claimed in claim 1, it is characterized in that, the skin of described coating is coated on described bottom by least one in magnetron sputtering method, spin-coating method, electrostatic spray, ultrasonic spraying process or infusion process.
8. lung arterial support as claimed in claim 1, is characterized in that, the skin of described coating contains antithrombotic reagent and/or promotes the somatomedin of endothelialization.
9. lung arterial support as claimed in claim 1, it is characterized in that, described silk screen is the net of corrugated silk formation from beginning to end, thus forms described cylindrical tube.
10. lung arterial support as claimed in claim 1, is characterized in that, to be multiple corrugated silk along the axis direction of described cylindrical tube be arranged in order described silk screen is interconnected and the net formed from beginning to end separately, thus form described cylindrical tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510520649.0A CN105232193A (en) | 2015-08-19 | 2015-08-19 | Pulmonary artery stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510520649.0A CN105232193A (en) | 2015-08-19 | 2015-08-19 | Pulmonary artery stent |
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| CN105232193A true CN105232193A (en) | 2016-01-13 |
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| CN201510520649.0A Pending CN105232193A (en) | 2015-08-19 | 2015-08-19 | Pulmonary artery stent |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106880430A (en) * | 2017-03-07 | 2017-06-23 | 北京迈迪顶峰医疗科技有限公司 | A kind of lung arterial support |
| CN107820416A (en) * | 2017-08-17 | 2018-03-20 | 鼎科医疗技术（苏州）有限公司 | Degradable metal support and its manufacture method |
| CN110025414A (en) * | 2019-04-16 | 2019-07-19 | 吉林大学中日联谊医院 | A kind of braided blood vessel stent and preparation method thereof |
| CN112402080A (en) * | 2020-11-13 | 2021-02-26 | 东南大学 | Full-coated degradable carotid artery stent and preparation method thereof |
| CN114748705A (en) * | 2022-05-12 | 2022-07-15 | 南京浩衍鼎业科技技术有限公司 | Polymer stent plated with metal film and preparation method thereof |
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| WO2003009777A2 (en) * | 2001-07-26 | 2003-02-06 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| CN100998897A (en) * | 2006-12-27 | 2007-07-18 | 天津大学 | Absorbale magnesium alloy stent possessing double controllable relieasing coating layer and its preparation method |
| CN201006050Y (en) * | 2006-10-18 | 2008-01-16 | 北京乐普医疗器械有限公司 | Biological degradable macromolecular medicament-carrying covering cardiovascular bracket |
| CN101214396A (en) * | 2008-01-03 | 2008-07-09 | 乐普（北京）医疗器械股份有限公司 | Controlled degradation magnesium alloy coating bracket and preparation thereof |
| CN101257860A (en) * | 2005-04-05 | 2008-09-03 | 万能医药公司 | Degradable implantable medical devices |
| US20110172763A1 (en) * | 2008-09-29 | 2011-07-14 | Robert Ndondo-Lay | Matrix Coated Stent |
| CN102908675A (en) * | 2012-10-29 | 2013-02-06 | 东南大学 | Absorbable suture nail for anastomat |
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2015
- 2015-08-19 CN CN201510520649.0A patent/CN105232193A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003009777A2 (en) * | 2001-07-26 | 2003-02-06 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
| CN101257860A (en) * | 2005-04-05 | 2008-09-03 | 万能医药公司 | Degradable implantable medical devices |
| CN201006050Y (en) * | 2006-10-18 | 2008-01-16 | 北京乐普医疗器械有限公司 | Biological degradable macromolecular medicament-carrying covering cardiovascular bracket |
| CN100998897A (en) * | 2006-12-27 | 2007-07-18 | 天津大学 | Absorbale magnesium alloy stent possessing double controllable relieasing coating layer and its preparation method |
| CN101214396A (en) * | 2008-01-03 | 2008-07-09 | 乐普（北京）医疗器械股份有限公司 | Controlled degradation magnesium alloy coating bracket and preparation thereof |
| US20110172763A1 (en) * | 2008-09-29 | 2011-07-14 | Robert Ndondo-Lay | Matrix Coated Stent |
| CN102908675A (en) * | 2012-10-29 | 2013-02-06 | 东南大学 | Absorbable suture nail for anastomat |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106880430A (en) * | 2017-03-07 | 2017-06-23 | 北京迈迪顶峰医疗科技有限公司 | A kind of lung arterial support |
| CN106880430B (en) * | 2017-03-07 | 2019-05-24 | 北京迈迪顶峰医疗科技有限公司 | A kind of lung arterial support |
| CN107820416A (en) * | 2017-08-17 | 2018-03-20 | 鼎科医疗技术（苏州）有限公司 | Degradable metal support and its manufacture method |
| CN110025414A (en) * | 2019-04-16 | 2019-07-19 | 吉林大学中日联谊医院 | A kind of braided blood vessel stent and preparation method thereof |
| CN110025414B (en) * | 2019-04-16 | 2021-07-20 | 吉林大学中日联谊医院 | Braided vascular stent and preparation method thereof |
| CN112402080A (en) * | 2020-11-13 | 2021-02-26 | 东南大学 | Full-coated degradable carotid artery stent and preparation method thereof |
| CN114748705A (en) * | 2022-05-12 | 2022-07-15 | 南京浩衍鼎业科技技术有限公司 | Polymer stent plated with metal film and preparation method thereof |
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Application publication date: 20160113 |