WO2024030956A3 - Cd39-specific binding agents and methods of using the same - Google Patents
Cd39-specific binding agents and methods of using the same Download PDFInfo
- Publication number
- WO2024030956A3 WO2024030956A3 PCT/US2023/071512 US2023071512W WO2024030956A3 WO 2024030956 A3 WO2024030956 A3 WO 2024030956A3 US 2023071512 W US2023071512 W US 2023071512W WO 2024030956 A3 WO2024030956 A3 WO 2024030956A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- binding agents
- methods
- same
- specific binding
- antibodies
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 title abstract 2
- 101150117736 Entpd1 gene Proteins 0.000 title 1
- 230000009870 specific binding Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 abstract 1
- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Binding agents (e.g., antibodies or antibody binding fragments thereof) that specifically bind to CD39 expressed on CD8+ T regulatory cells, and their use in the treatment of diseases or disorders, such as an inflammatory disease or an autoimmune disease, are provided.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202263370353P | 2022-08-03 | 2022-08-03 | |
US63/370,353 | 2022-08-03 | ||
US202263380879P | 2022-10-25 | 2022-10-25 | |
US63/380,879 | 2022-10-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2024030956A2 WO2024030956A2 (en) | 2024-02-08 |
WO2024030956A3 true WO2024030956A3 (en) | 2024-04-11 |
Family
ID=87800863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2023/071512 WO2024030956A2 (en) | 2022-08-03 | 2023-08-02 | Cd39-specific binding agents and methods of using the same |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2024030956A2 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2737907A2 (en) * | 2007-05-07 | 2014-06-04 | MedImmune, LLC | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
WO2016120789A1 (en) * | 2015-01-28 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Agonistic icos binding proteins |
WO2019027935A1 (en) * | 2017-07-31 | 2019-02-07 | Tizona Therapeutics | Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies |
WO2021037037A1 (en) * | 2019-08-27 | 2021-03-04 | Elpiscience (Suzhou) Biopharma, Ltd. | Novel anti-cd39 antibodies |
WO2021209356A1 (en) * | 2020-04-14 | 2021-10-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
JPS63501765A (en) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | Antibody gene module assembly, antibodies produced thereby, and uses |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
DE69233254T2 (en) | 1991-06-14 | 2004-09-16 | Genentech, Inc., South San Francisco | Humanized Heregulin antibody |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
US6080560A (en) | 1994-07-25 | 2000-06-27 | Monsanto Company | Method for producing antibodies in plant cells |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
DE19742706B4 (en) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | lipocalin muteins |
EP1068241B1 (en) | 1998-04-02 | 2007-10-10 | Genentech, Inc. | Antibody variants and fragments thereof |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
US20030167531A1 (en) | 1998-07-10 | 2003-09-04 | Russell Douglas A. | Expression and purification of bioactive, authentic polypeptides from plants |
US6512162B2 (en) | 1998-07-10 | 2003-01-28 | Calgene Llc | Expression of eukaryotic peptides in plant plastids |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
BR0014945A (en) | 1999-10-21 | 2004-08-31 | Monsanto Co | Posttranslational modification of recombinant proteins produced in plants |
NZ521540A (en) | 2000-04-11 | 2004-09-24 | Genentech Inc | Multivalent antibodies and uses therefor |
JP5291279B2 (en) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | A collection of repetitive proteins containing repetitive modules |
HU227217B1 (en) | 2002-12-16 | 2010-11-29 | Genentech Inc | Immunoglobulin variants and uses thereof |
AU2004242846A1 (en) | 2003-05-31 | 2004-12-09 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders |
AU2003275958A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
AU2004283299B2 (en) | 2003-10-22 | 2009-06-18 | Alder Biopharmaceuticals, Inc. | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
SI1691833T1 (en) | 2003-11-28 | 2010-06-30 | Micromet Ag | Compositions comprising polypeptides |
US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
NZ549872A (en) | 2004-04-13 | 2009-09-25 | Hoffmann La Roche | Anti-P-selectin antibodies |
TWI380996B (en) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | Anti-ox40l antibodies |
NZ612578A (en) | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
ES2616316T3 (en) | 2005-10-11 | 2017-06-12 | Amgen Research (Munich) Gmbh | Compositions comprising specific antibodies for different species and uses thereof |
WO2008027236A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Multispecific antibodies |
WO2008119567A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific cd3-epsilon binding domain |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
EP2235064B1 (en) | 2008-01-07 | 2015-11-25 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
EP2238170B1 (en) | 2008-01-31 | 2016-11-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
DK2654789T3 (en) | 2010-12-22 | 2018-09-03 | Orega Biotech | ANTIBODIES AGAINST HUMAN CD39 AND USE THEREOF |
PT2691417T (en) | 2011-03-29 | 2018-10-31 | Roche Glycart Ag | Antibody fc variants |
ES2659764T3 (en) | 2011-08-23 | 2018-03-19 | Roche Glycart Ag | Bispecific T-cell activating antigen binding molecules |
PL3430397T3 (en) | 2016-03-14 | 2022-04-04 | Biogen International Neuroscience Gmbh | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins |
AU2018314257A1 (en) | 2017-08-11 | 2020-02-13 | Research Development Foundation | Engineered antibody Fc variants for enhanced serum half life |
-
2023
- 2023-08-02 WO PCT/US2023/071512 patent/WO2024030956A2/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2737907A2 (en) * | 2007-05-07 | 2014-06-04 | MedImmune, LLC | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
WO2016120789A1 (en) * | 2015-01-28 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Agonistic icos binding proteins |
WO2019027935A1 (en) * | 2017-07-31 | 2019-02-07 | Tizona Therapeutics | Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies |
WO2021037037A1 (en) * | 2019-08-27 | 2021-03-04 | Elpiscience (Suzhou) Biopharma, Ltd. | Novel anti-cd39 antibodies |
WO2021209356A1 (en) * | 2020-04-14 | 2021-10-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
Non-Patent Citations (8)
Title |
---|
CINZIA SOLINAS ET AL: "The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy", ESMO OPEN, vol. 5, no. 1, 1 January 2020 (2020-01-01), pages e000544, XP055735963, DOI: 10.1136/esmoopen-2019-000544 * |
HU DAN ET AL: "CD8+ Tregs kill pathogenic cells to avert autoimmunity", TRENDS IN IMMUNOLOGY, vol. 43, no. 6, 1 June 2022 (2022-06-01), GB, pages 415 - 416, XP093112296, ISSN: 1471-4906, Retrieved from the Internet <URL:https://www.cell.com/trends/immunology/pdf/S1471-4906(22)00092-8.pdf> DOI: 10.1016/j.it.2022.04.006 * |
IVAN PERROT ET AL: "Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies", CELL REPORTS, vol. 27, no. 8, 1 May 2019 (2019-05-01), US, pages 2411 - 2425.e9, XP055610275, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.04.091 * |
LI JING ET AL: "KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19", SCIENCE, vol. 376, no. 6590, 15 April 2022 (2022-04-15), US, XP093112109, ISSN: 0036-8075, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995031/pdf/science.abi9591.pdf> DOI: 10.1126/science.abi9591 * |
SIMPSON TYLER R ET AL: "Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)", CURRENT OPINION IN IMMUNOLOGY, vol. 22, no. 3, 1 June 2010 (2010-06-01), GB, pages 326 - 332, XP093112300, ISSN: 0952-7915, Retrieved from the Internet <URL:https://pdf.sciencedirectassets.com/272032/1-s2.0-S0952791510X00048/1-s2.0-S0952791510000026/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEOX//////////wEaCXVzLWVhc3QtMSJHMEUCIEcy1LN4tWYuGxXwwgfynwykhNLiYCb3VIRO+NYA1xHcAiEAoSl96oP6sTHWLTpkRYR9tFfvr0xDv1jn1hny2PXfF0cqsgUIXhAFGgwwNTkwMDM1NDY4NjUiDI0Q7> DOI: 10.1016/j.coi.2010.01.001 * |
TIMPERI ELEONORA ET AL: "CD39 Regulation and Functions in T Cells", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 15, 28 July 2021 (2021-07-28), Basel, CH, pages 8068, XP093112249, ISSN: 1422-0067, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348030/pdf/ijms-22-08068.pdf> DOI: 10.3390/ijms22158068 * |
VIEYRA-LOBATO MARTHA R. ET AL: "Description of CD8 + Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer", JOURNAL OF IMMUNOLOGY RESEARCH, vol. 2018, 5 August 2018 (2018-08-05), US, pages 1 - 16, XP093112250, ISSN: 2314-8861, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098849/pdf/JIR2018-3758713.pdf> DOI: 10.1155/2018/3758713 * |
ZHANG ZHENQING ET AL.: "Abstract 5528: A highly potent anti-CD39 biparatopic antibody and bispecific for cancer therapy | Cancer Research | American Association for Cancer Research", CANCER RESEARCH, 15 June 2022 (2022-06-15), XP093108860, Retrieved from the Internet <URL:https://aacrjournals.org/cancerres/article/82/12_Supplement/5528/700582/Abstract-5528-A-highly-potent-anti-CD39> * |
Also Published As
Publication number | Publication date |
---|---|
WO2024030956A2 (en) | 2024-02-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1603949B8 (en) | Antibodies against human il-21 receptor and uses therefor | |
MY146664A (en) | Antibodies against human il-22 and uses therefor | |
WO2007100643A3 (en) | Methods of using antibodies against human il-22 | |
WO2019178269A3 (en) | Antibodies that bind cd39 and uses thereof | |
IL173477A (en) | Multispecific antibody comprising binding arms which bind to two different antigens on the same target cell and its use in the preparation of a pharmaceutical composition | |
WO2006077471A3 (en) | Combining therapies targeting multiple toll-like receptors and use thereof | |
NO20073063L (en) | Monoclonal antibody to NKG2A | |
WO2007126439A3 (en) | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r | |
WO2005110474A3 (en) | HUMANIZED FcϜRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF | |
MX2010003574A (en) | Il-23 antibodies. | |
AU2018282094A1 (en) | Antibodies that specifically bind PD-1 and methods of use | |
WO2006003179A3 (en) | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use | |
WO2007084775A3 (en) | Compositions and methods for modulation of suppressor t cell activation | |
WO2011094259A3 (en) | Cd127 binding proteins | |
WO2021055253A3 (en) | Anti-tnfr2 antibodies and methods of use | |
WO2005120557A3 (en) | Inhibition of macrophage-stimulating protein receptor (ron) | |
WO2022081718A8 (en) | Anti-c-c chemokine receptor 8 (ccr8) antibodies and methods of use thereof | |
WO2016173605A8 (en) | Ultra-potent neutralization of cytokines by multispecific antibodies and uses thereof | |
WO2020089396A3 (en) | Composition and methods of treating inflammatory and autoimmune diseases | |
MX2021011040A (en) | Antibodies targeting c5ar. | |
WO2021263167A3 (en) | Il-10 muteins and fusion proteins thereof | |
MY149448A (en) | Interleukin-21 receptor binding proteins | |
WO2021087368A3 (en) | Anti-cd45 antibodies and conjugates thereof | |
WO2024030956A3 (en) | Cd39-specific binding agents and methods of using the same | |
WO2020185796A9 (en) | High avidity wt1 t cell receptors and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 23761376 Country of ref document: EP Kind code of ref document: A2 |