WO2023137297A3 - 5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo inhibitors and uses thereof - Google Patents

5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo inhibitors and uses thereof Download PDF

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Publication number
WO2023137297A3
WO2023137297A3 PCT/US2023/060437 US2023060437W WO2023137297A3 WO 2023137297 A3 WO2023137297 A3 WO 2023137297A3 US 2023060437 W US2023060437 W US 2023060437W WO 2023137297 A3 WO2023137297 A3 WO 2023137297A3
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WO
WIPO (PCT)
Prior art keywords
thieno
pyrrole
dihydro
sumo
inhibitors
Prior art date
Application number
PCT/US2023/060437
Other languages
French (fr)
Other versions
WO2023137297A2 (en
Inventor
Tom Nguyen
Mary Walton
Original Assignee
Suvalent Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Suvalent Therapeutics, Inc. filed Critical Suvalent Therapeutics, Inc.
Publication of WO2023137297A2 publication Critical patent/WO2023137297A2/en
Publication of WO2023137297A3 publication Critical patent/WO2023137297A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to compounds and compositions capable of acting as inhibitors of small ubiquitin-like modifier (SUMO) family of proteins. The compounds and compositions may be used in the treatment of cancer. There are disclosed, inter alia, methods of inhibiting an El enzyme, and compounds useful for inhibiting an El enzyme.
PCT/US2023/060437 2022-01-11 2023-01-11 5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo inhibitors and uses thereof WO2023137297A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263298372P 2022-01-11 2022-01-11
US63/298,372 2022-01-11

Publications (2)

Publication Number Publication Date
WO2023137297A2 WO2023137297A2 (en) 2023-07-20
WO2023137297A3 true WO2023137297A3 (en) 2023-08-24

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ID=87279678

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Application Number Title Priority Date Filing Date
PCT/US2023/060437 WO2023137297A2 (en) 2022-01-11 2023-01-11 5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo inhibitors and uses thereof

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WO (1) WO2023137297A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040385A1 (en) * 1997-03-07 1998-09-17 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
WO2016106029A1 (en) * 2014-12-22 2016-06-30 Eli Lilly And Company Thieno[2,3-c]pyrrol-4-one derivatives as erk inhibitors
WO2020191151A1 (en) * 2019-03-19 2020-09-24 Oncovalent Therapeutics Inc. Sumo inhibitor compounds and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040385A1 (en) * 1997-03-07 1998-09-17 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
WO2016106029A1 (en) * 2014-12-22 2016-06-30 Eli Lilly And Company Thieno[2,3-c]pyrrol-4-one derivatives as erk inhibitors
WO2020191151A1 (en) * 2019-03-19 2020-09-24 Oncovalent Therapeutics Inc. Sumo inhibitor compounds and uses thereof

Also Published As

Publication number Publication date
WO2023137297A2 (en) 2023-07-20

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