WO2023051075A1

WO2023051075A1 - Continuous blood-glucose correction method and apparatus, and electronic device

Info

Publication number: WO2023051075A1
Application number: PCT/CN2022/113237
Authority: WO
Inventors: 刘煜; 王新建
Original assignee: 苏州睿感医疗科技有限公司
Priority date: 2021-09-29
Filing date: 2022-08-18
Publication date: 2023-04-06
Also published as: CN115877009A

Abstract

The present application relates to the field of medical science and technology. Provided are a continuous blood-glucose correction method and apparatus, and an electronic device. The continuous blood-glucose correction method comprises: firstly, according to a set correction period, respectively collecting a transient output current and a steady-state output current of a sensor; then, determining a sensitivity coefficient of the sensor according to a current value and change characteristics of the transient output current; and finally, correcting the steady-state output current according to the sensitivity coefficient, and determining a blood-glucose value on the basis of the corrected steady-state output current. Therefore, the automatic correction of blood glucose can be realized, thereby improving the efficiency of continuous blood-glucose correction.

Description

Continuous blood sugar correction method, device and electronic equipment

This application claims priority to a Chinese patent application filed with the China Patent Office on September 29, 2021, with application number 202111148201.2, and titled "Continuous Blood Glucose Correction Method, Apparatus, and Electronic Equipment," the entire contents of which are hereby incorporated by reference Applying.

technical field

The present application relates to the field of medical science and technology, in particular to a continuous blood sugar correction method, device and electronic equipment.

Background technique

The continuous glucose monitoring system (Continuous Glucose Monitoring, CGM) contacts the glucose in the interstitial fluid through the subcutaneous sensor. When the voltage applied to the sensor reaches a predetermined level, it will cause the glucose redox reaction, and then convert the chemical signal into an electrical signal. signal, generating a sense current. According to the correlation between the interstitial fluid glucose level and the blood glucose level, the detection current can be further converted into a blood glucose value.

However, the detection accuracy of CGM will be affected by the performance of the sensor, and the performance of the sensor will continue to decay with the prolongation of use time. Therefore, it is necessary to regularly correct the blood glucose detection results of the CGM, so as to ensure the detection accuracy of the CGM in the case of sensor performance degradation. The current commonly used correction method is to regularly collect blood from the patient for testing, and then input the detected blood glucose value into the CGM as a correction value. However, this method is very painful and difficult to achieve high-frequency correction; moreover, it requires manual blood sampling and manual input of correction values into CGM, which is inconvenient to operate.

Contents of the invention

The embodiments of the present application provide a method, device and electronic equipment for continuous blood sugar correction, which can realize automatic blood sugar correction and improve the efficiency of continuous blood sugar correction.

In the first aspect, the embodiment of the present application provides a continuous blood sugar correction method, including: respectively collecting the transient output current and the steady-state output current of the sensor according to the set correction period; according to the current value of the transient output current and Change characteristics, determine the sensitivity coefficient of the sensor; correct the steady-state output current according to the sensitivity coefficient, and determine the blood sugar level based on the corrected steady-state output current.

In one possible implementation manner, the transient output current is output when a transient voltage is applied to the sensor, and the steady-state output current is output when a steady-state voltage is applied to the sensor; wherein, the The voltage value of the transient voltage changes with time and the voltage waveform of the transient voltage includes any one or more of the following combinations: square wave; pulse wave; triangular wave; step wave; trapezoidal wave; linear wave; white noise wave; sine wave.

In one possible implementation manner, correcting the steady-state output current according to the sensitivity coefficient includes: correcting the original comprehensive state parameter of the sensor according to the sensitivity coefficient; using the corrected comprehensive state parameter A correction is made to the steady state output current of the sensor.

In one possible implementation manner, correcting the original comprehensive state parameters of the sensor according to the sensitivity coefficient includes: detecting the human body temperature in the current test environment; determining the state correction according to the human body temperature and the sensitivity coefficient value; the original comprehensive state parameter of the sensor is corrected by using the state correction value.

In one possible implementation manner, using the corrected comprehensive state parameter to correct the steady-state output current of the sensor includes: determining the change between the corrected comprehensive state parameter and the original comprehensive state parameter rate; according to the rate of change and the parameter value of the corrected comprehensive state parameter, it is determined that the sensor is in an attenuation state, and the steady state output current of the sensor is corrected by using the corrected comprehensive state parameter.

In one possible implementation manner, determining that the sensor is in an attenuation state according to the rate of change and the parameter value of the corrected comprehensive state parameter includes: the rate of change is in the first threshold interval, and the corrected If the final comprehensive state parameter is less than the second threshold interval, the sensor is in an attenuation state.

In the second aspect, the embodiment of the present application provides a continuous blood sugar correction device, including: a collection module, used to collect the transient output current and steady-state output current of the sensor according to the set correction period; The current value and change characteristics of the transient output current determine the sensitivity coefficient of the sensor; the execution module is used to correct the steady-state output current according to the sensitivity coefficient, and based on the corrected steady-state output current Determine blood sugar levels.

In a third aspect, an embodiment of the present application provides an electronic device, including: at least one processor; and at least one memory communicated with the processor, wherein: the memory stores a program executable by the processor Instructions, the processor invokes the program instructions to execute the method as described in the first aspect.

In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, where the computer-readable storage medium stores computer instructions, and the computer instructions cause the computer to execute the method as described in the first aspect.

In the above technical solution, firstly, the transient output current and the steady output current of the sensor can be respectively collected according to the set calibration cycle. Then, the sensitivity coefficient of the sensor can be determined according to the current value and variation characteristics of the transient output current. Finally, the steady-state output current can be corrected according to the sensitivity coefficient, and the blood glucose level can be determined based on the corrected steady-state output current. Thereby, the automatic correction of blood sugar can be realized, and the efficiency of continuous blood sugar correction can be improved.

Description of drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the accompanying drawings that need to be used in the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present application. Those of ordinary skill in the art can also obtain other drawings based on these drawings without any creative effort.

Fig. 1 is a flow chart of a continuous blood sugar correction method provided by the embodiment of the present application;

Fig. 2 is a voltage schematic diagram of a continuous blood sugar correction method provided by the embodiment of the present application;

FIG. 3 is a schematic current diagram of a continuous blood sugar correction method provided in an embodiment of the present application;

FIG. 4 is a curve diagram of a comprehensive sensor state parameter change provided by the embodiment of the present application;

Fig. 5 is a schematic structural diagram of a continuous blood sugar correction device provided by an embodiment of the present application;

FIG. 6 is a schematic structural diagram of an electronic device provided by an embodiment of the present application.

Detailed ways

In order to better understand the technical solutions of the present application, the embodiments of the present application will be described in detail below in conjunction with the accompanying drawings.

It should be clear that the described embodiments are only some of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present application.

Terms used in the embodiments of the present application are only for the purpose of describing specific embodiments, and are not intended to limit the present application. The singular forms "a", "said" and "the" used in the embodiments of this application and the appended claims are also intended to include plural forms unless the context clearly indicates otherwise.

An embodiment of the present application may provide a continuous blood sugar correction device, and the continuous blood sugar correction device may be used to implement the continuous blood sugar correction method provided in the embodiment of the present application. The continuous blood glucose correction device may be any continuous blood glucose monitoring device, which is not limited in this application.

Figure 1 is a flow chart of a continuous blood sugar correction method provided in the embodiment of the present application. As shown in Figure 1, the above continuous blood sugar correction method may include:

Step 101 , respectively collect the transient output current and the steady output current of the sensor according to the set calibration period.

A continuous blood glucose monitoring device generally includes three main components, namely a sensor, a transmitter, and a receiver. Among them, the sensor is usually placed under the skin, in contact with glucose in the interstitial fluid. After the continuous blood glucose monitoring device is powered on, a preset voltage can be applied to the sensor, which can cause the redox reaction of glucose in the interstitial fluid, and then generate an electrical signal. Further, the generated electrical signal can be received by the transmitter, and the electrical signal can be sent to the receiver through bluetooth communication or other means. Based on the principle of algorithm, the receiver can convert the received electrical signal into blood glucose level for display.

In the embodiment of the present application, during each operation of the blood glucose monitoring device, when voltage is applied to the sensor, it may include two stages, namely, a transient voltage stage and a steady state voltage stage. The duration of the two phases may be the same, for example, it may be 140 seconds.

Wherein, the voltage applied in the transient voltage stage is a variable voltage, and its voltage value changes with time. Exemplarily, the voltage waveform of the transient voltage can be a square wave, a pulse wave, a triangular wave, a step wave, a trapezoidal wave, a linear wave, Any one or a combination of white noise, sine wave, etc.

Correspondingly, the voltage applied in the steady-state voltage stage is a steady voltage, and its voltage value is equal to the preset voltage value required by the glucose oxidation (reduction) reaction. Therefore, during the steady-state voltage phase, the redox reaction of glucose in the interstitial fluid is mainly initiated. In an actual implementation process, the preset voltage value may generally be 0.3-0.6V.

For ease of understanding, Figure 2 shows a possible implementation of applying voltage to the sensor. As shown in Figure 2, the triangular wave voltage in the figure corresponds to the transient process, and the 0.5V constant voltage corresponds to the steady-state process. V _tn-2 and V _tn are respectively a peak voltage value and a valley voltage value before entering the steady-state process, and the values in the figure are 0.7V and 0.2V respectively. It should be noted that FIG. 2 is only an exemplary implementation manner, and is not intended to limit the embodiment of the present application.

Based on the above description, the embodiment of the present application can collect the output currents of the transient voltage stage and the steady state voltage stage respectively, that is, the transient output current and the steady state output current according to the set correction cycle. It can be understood that the transient output current is the current value generated by the oxidation-reduction reaction in the transient voltage stage, and the steady-state output current is the current value generated by the redox reaction in the steady-state voltage stage. Wherein, the period length of the set calibration period can be set according to actual needs, for example, it can be 5 minutes.

For ease of understanding, Figure 3 shows a possible schematic diagram of the output current. The output current shown in Figure 3 corresponds to the applied voltage in Figure 2. As shown in Figure 3, I _s represents the steady-state output current, Itn _-2 represents the transient output current corresponding to the above-mentioned peak voltage value V _tn-2 , and _Itn represents the transient output current corresponding to the above-mentioned valley voltage value V _tn .

Step 102: Determine the sensitivity coefficient of the sensor according to the current value and variation characteristics of the transient output current.

During the normal use of the sensor, due to the influence of various factors (aging of sensor components, fluctuations in the human body environment, and attenuation of reaction enzymes, etc.), the sensitivity and performance of the sensor will be attenuated to varying degrees with the prolongation of use time. Based on the attenuation of sensor sensitivity and performance, the above-mentioned transient output current and steady-state output current will also fluctuate with the prolongation of the use time of the sensor, thereby affecting the detection accuracy of blood glucose.

Based on the above description, the embodiment of the present application can learn the current value and variation characteristics of the transient output current, and obtain the corresponding relationship between the current value and variation characteristics of the transient output current and the sensitivity coefficient of the sensor. Therefore, the sensitivity coefficient of the sensor can be determined according to the current value and variation characteristics of the transient output current.

Step 103, correcting the steady-state output current according to the sensitivity coefficient, and determining the blood glucose level based on the corrected steady-state output current.

In the embodiment of the present application, firstly, the original comprehensive state parameters of the sensor may be corrected according to the sensitivity coefficient.

Considering the influence of the human body temperature on the monitoring accuracy, the embodiment of the present application can detect the human body temperature in the current test environment through a temperature sensor. Then, the state correction value can be determined according to the body temperature and the sensitivity coefficient.

After the state correction value is determined, the original comprehensive state parameters of the sensor can be corrected by using the state correction value, so as to obtain the comprehensive state parameters of the sensor in the current test environment.

Wherein, the original comprehensive state parameter refers to the comprehensive state parameter before the execution of the current continuous blood glucose correction operation. In particular, when the current continuous blood glucose correction operation is the first continuous blood glucose correction operation, the original comprehensive state parameter is equal to the standard value of the input sensor when the device leaves the factory.

Then, the corrected comprehensive state parameters can be used to correct the steady-state output current of the sensor, and the blood glucose level can be determined based on the corrected steady-state output current.

In the embodiment of the present application, the rate of change between the revised comprehensive state parameter and the original comprehensive state parameter may be determined.

Further, after determining that the sensor is in an attenuation state according to the rate of change and the parameter value of the corrected comprehensive state parameter, the steady-state output current of the sensor can be corrected by using the corrected comprehensive state parameter.

Specifically, if the rate of change is within the first threshold interval and the corrected comprehensive state parameter is smaller than the second threshold interval, it is determined that the sensor is in an attenuation state.

Wherein, the values of the above-mentioned first threshold interval and the second threshold interval can be determined according to the change curve of the comprehensive state parameter K of the sensor under standard conditions.

For ease of understanding, FIG. 4 shows a schematic diagram of the change curve of the comprehensive state parameter K of the continuous blood glucose sensor under different conditions. Among them, the predicted value of K is the change curve of K under standard conditions. The predicted value K may be a change curve of the sensor at different stages within a service life (for example, 15 days) obtained through testing in a standard laboratory environment before the sensor leaves the factory. This change curve can be used as a standard value input sensor.

After it is determined that the sensor is in an attenuation state, the steady-state output current of the sensor, that is, the current generated by the redox reaction of glucose, can be corrected by using the corrected comprehensive state parameters. Specifically, the steady-state output current may be divided by the above-mentioned corrected comprehensive state parameter to obtain the corrected steady-state output current. A blood glucose value can then be determined based on the corrected steady state output current.

Further, if the above-mentioned change rate is in the first threshold interval and the corrected comprehensive state parameter is in the second threshold interval, at this time, it can be determined that the sensor is in a normal state. Then, the blood glucose level can be determined directly based on the steady state output current.

If the above-mentioned change rate is less than the first threshold interval and the corrected comprehensive state parameter is less than the second threshold interval, at this time, it can be considered that the sensor is damaged or has reached the maximum service life, and it can be determined that the sensor is in a state to be replaced.

Further, the embodiment of the present application may also provide a user reminder function, which is used to feed back the execution information of continuous blood sugar correction to the user. Exemplarily, a voice or text prompt can be issued to the user when the continuous blood glucose correction starts and/or ends. Further, when it is determined that the sensor is in an attenuation state and the correction operation is performed, the user may be prompted to complete the correction operation. When it is determined that the sensor is in a normal state, it may prompt that the current state is normal. When it is determined that the sensor is in a state to be replaced, the user may be prompted to replace the sensor in time. Therefore, the user can know the current operation execution status in time, which improves the user experience.

In the above technical solution, firstly, the transient output current and the steady output current of the sensor can be respectively collected according to the set calibration cycle. Then, the sensitivity coefficient of the sensor can be determined according to the current value and variation characteristics of the transient output current. Finally, the steady-state output current can be corrected according to the sensitivity coefficient, and the blood glucose level can be determined based on the corrected steady-state output current. Thereby, the automatic correction of blood sugar can be realized, and the efficiency of continuous blood sugar correction can be improved. Moreover, the continuous blood sugar correction method provided by the present application does not need to collect fingertip blood, does not cause pain to the user, and effectively improves the user experience.

Fig. 5 is a schematic structural diagram of a continuous blood sugar correction device provided by an embodiment of the present application. As shown in FIG. 5 , the above-mentioned continuous blood sugar correction device may include: a collection module 41 , a determination module 42 and an execution module 43 .

The acquisition module 41 is configured to respectively acquire the transient output current and the steady output current of the sensor according to the set calibration cycle.

The determination module 42 is configured to determine the sensitivity coefficient of the sensor according to the current value and variation characteristics of the transient output current.

The execution module 43 is configured to correct the steady-state output current according to the sensitivity coefficient, and determine the blood glucose level based on the corrected steady-state output current.

In a specific implementation, the above-mentioned device also includes: a power supply module 44, the transient output current is output when the power supply module 44 applies a transient voltage to the sensor, and the steady-state output current is when the power supply module 44 applies a steady-state voltage to the sensor Output; wherein, the voltage value of the transient voltage changes with time and the voltage waveform includes any one or a combination of the following: square wave; pulse wave; triangular wave; step wave; trapezoidal wave; linear wave; white noise wave; sine wave.

In a specific implementation manner, the execution module 43 is specifically configured to correct the original comprehensive state parameters of the sensor according to the sensitivity coefficient; use the corrected comprehensive state parameters to correct the steady-state output current of the sensor.

In a specific implementation, the above-mentioned device also includes: a temperature detection module 45 for detecting the temperature of the human body in the current test environment; the execution module 43 is specifically used for determining the state correction value according to the human body temperature and the sensitivity coefficient; using the state correction Correct the original comprehensive state parameters of the sensor.

In a specific implementation, the execution module 43 is specifically used to: determine the rate of change between the corrected comprehensive state parameter and the original comprehensive state parameter; State, using the corrected comprehensive state parameters to correct the steady-state output current of the sensor.

In a specific implementation manner, if the rate of change is in the first threshold interval and the corrected comprehensive state parameter is smaller than the second threshold interval, then the execution module 43 determines that the sensor is in an attenuation state.

In the embodiment of the present application, firstly, the acquisition module 41 can respectively acquire the transient output current and the steady output current of the sensor according to the set calibration period. Then, the determination module 42 can determine the sensitivity coefficient of the sensor according to the current value and variation characteristics of the transient output current. Finally, the execution module 43 can correct the steady-state output current according to the sensitivity coefficient, and determine the blood glucose level based on the corrected steady-state output current. Thereby, the automatic correction of blood sugar can be realized, and the efficiency of continuous blood sugar correction can be improved.

FIG. 6 is a schematic structural diagram of an electronic device provided by an embodiment of the present application. As shown in Figure 6, the above-mentioned electronic device may include at least one processor; and at least one memory connected in communication with the above-mentioned processor, wherein: the memory stores program instructions executable by the processor, and the above-mentioned processor calls the above-mentioned program instructions to be able to Execute the continuous blood sugar correction method provided in the embodiment of the present application.

Wherein, the above-mentioned electronic device may be a continuous blood glucose monitoring device, and this embodiment does not limit the specific form of the above-mentioned electronic device.

FIG. 6 shows a block diagram of an exemplary electronic device suitable for implementing embodiments of the present application. The electronic device shown in FIG. 6 is only an example, and should not limit the functions and scope of use of the embodiment of the present application.

As shown in Figure 6, the electronic device takes the form of a general-purpose computing device. The components of the electronic device may include, but are not limited to: one or more processors 410, a memory 430, and a communication bus 440 connecting different system components (including the memory 430 and the processor 410).

Communication bus 440 represents one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or a local bus using any of a variety of bus structures. For example, these architectures include but are not limited to Industry Standard Architecture (Industry Standard Architecture; hereinafter referred to as: ISA) bus, Micro Channel Architecture (Micro Channel Architecture; hereinafter referred to as: MAC) bus, enhanced ISA bus, video electronics Standards Association (Video Electronics Standards Association; hereinafter referred to as: VESA) local bus and Peripheral Component Interconnection (hereinafter referred to as: PCI) bus.

Electronic devices typically include a variety of computer system readable media. These media can be any available media that can be accessed by the electronic device and include both volatile and nonvolatile media, removable and non-removable media.

The memory 430 may include a computer system-readable medium in the form of a volatile memory, such as a random access memory (Random Access Memory; RAM for short) and/or a cache memory. The electronic device may further include other removable/non-removable, volatile/nonvolatile computer system storage media. Although not shown in FIG. 6, a disk drive for reading and writing to a removable nonvolatile disk (such as a "floppy disk") may be provided, as well as a disk drive for a removable nonvolatile disk (such as a CD-ROM (Compact Disc Read Only Memory; hereinafter referred to as: CD-ROM), Digital Video Disc Read Only Memory (hereinafter referred to as: DVD-ROM) or other optical media). In these cases, each drive may be connected to communication bus 440 through one or more data media interfaces. The memory 430 may include at least one program product having a set (for example, at least one) of program modules configured to perform the functions of the various embodiments of the present application.

A program/utility having a set (at least one) of program modules may be stored in memory 430, such program modules including - but not limited to - an operating system, one or more application programs, other program modules, and program data , each or some combination of these examples may include implementations of network environments. The program modules generally perform the functions and/or methods in the embodiments described herein.

The electronic device can also communicate with one or more external devices (e.g., keyboards, pointing devices, displays, etc.), and with one or more devices that enable a user to interact with the electronic device, and/or communicate with one or more Any device (eg, network card, modem, etc.) capable of communicating with one or more other computing devices communicates. Such communication may occur through communication interface 420 . Moreover, the electronic device can also communicate with one or more networks (such as a local area network (Local Area Network; hereinafter referred to as: LAN), a wide area network (Wide Area Network; hereinafter referred to as: WAN) and/or or a public network, such as the Internet), the above-mentioned network adapter can communicate with other modules of the electronic device through the communication bus 440 . It should be understood that although not shown in FIG. 6, other hardware and/or software modules may be used in conjunction with the electronic device, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, disk arrays (Redundant Arrays of Independent Drives; hereinafter referred to as: RAID) system, tape drive and data backup storage system, etc.

The processor 410 executes various functional applications and data processing by running the programs stored in the memory 430, for example, realizing the continuous blood sugar correction method provided by the embodiment of the present application.

The embodiment of the present application further provides a computer-readable storage medium, wherein the computer-readable storage medium stores computer instructions, and the computer instructions cause the computer to execute the continuous blood sugar correction method provided in the embodiment of the present application.

Any combination of one or more computer-readable storage media may be used for the above-mentioned computer-readable storage medium. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A computer readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination thereof. More specific examples (non-exhaustive list) of computer-readable storage media include: electrical connections with one or more conductors, portable computer disks, hard disks, Random Access Memory (RAM), Read Only Memory (Read Only Memory) ; Hereinafter referred to as: ROM), Erasable Programmable Read Only Memory (Erasable Programmable Read Only Memory; hereinafter referred to as: EPROM) or flash memory, optical fiber, portable compact disk read-only memory (CD-ROM), optical storage device, magnetic memory components, or any suitable combination of the above. In this document, a computer-readable storage medium may be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

A computer readable signal medium may include a data signal carrying computer readable program code in baseband or as part of a carrier wave. Such propagated data signals may take many forms, including - but not limited to - electromagnetic signals, optical signals, or any suitable combination of the foregoing. A computer-readable signal medium may also be any computer-readable medium other than a computer-readable storage medium, which can send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, apparatus, or device. .

Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including - but not limited to - wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.

In the description of this specification, descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" mean that specific features described in connection with the embodiment or example , structure, material or characteristic is included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the described specific features, structures, materials or characteristics may be combined in any suitable manner in any one or more embodiments or examples. In addition, those skilled in the art can combine and combine different embodiments or examples and features of different embodiments or examples described in this specification without conflicting with each other.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present application, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

Any process or method descriptions in flowcharts or otherwise described herein may be understood to represent a module, segment or portion of code comprising one or more executable instructions for implementing custom logical functions or steps of a process , and the scope of preferred embodiments of the present application includes additional implementations in which functions may be performed out of the order shown or discussed, including in substantially simultaneous fashion or in reverse order depending on the functions involved, which shall It should be understood by those skilled in the art to which the embodiments of the present application belong.

In the several embodiments provided in this application, it should be understood that the disclosed systems, devices and methods may be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the division of the units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined Or it can be integrated into another system, or some features can be ignored, or not implemented. In another point, the mutual coupling or direct coupling or communication connection shown or discussed may be through some interfaces, and the indirect coupling or communication connection of devices or units may be in electrical, mechanical or other forms.

In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, each unit may exist separately physically, or two or more units may be integrated into one unit. The above-mentioned integrated units can be implemented in the form of hardware, or in the form of hardware plus software functional units.

The above is only a preferred embodiment of the application, and is not intended to limit the application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the application should be included in the application. within the scope of protection.

Claims

A continuous blood sugar correction method, characterized by comprising:

According to the set calibration period, the transient output current and steady output current of the sensor are respectively collected;

determining the sensitivity coefficient of the sensor according to the current value and variation characteristics of the transient output current;

The steady-state output current is corrected according to the sensitivity coefficient, and the blood glucose level is determined based on the corrected steady-state output current.
The method according to claim 1, wherein the transient output current is output when a transient voltage is applied to the sensor, and the steady-state output current is output when a steady-state voltage is applied to the sensor ;

Wherein, the voltage value of the transient voltage changes with time and the voltage waveform of the transient voltage includes any one or more of the following combinations: square wave; pulse wave; triangular wave; step wave; trapezoidal wave; linear wave ; white noise wave; sine wave.
The method according to claim 1, wherein correcting the steady-state output current according to the sensitivity coefficient comprises:

Correcting the original comprehensive state parameter of the sensor according to the sensitivity coefficient;

The steady-state output current of the sensor is corrected by using the corrected comprehensive state parameters.
The method according to claim 3, characterized in that, modifying the original comprehensive state parameters of the sensor according to the sensitivity coefficient includes:

Detect the human body temperature in the current test environment;

determining a state correction value according to the human body temperature and the sensitivity coefficient;

The original comprehensive state parameter of the sensor is corrected by using the state correction value.
The method according to claim 4, wherein the correction of the steady-state output current of the sensor is performed using the corrected comprehensive state parameters, including:

determining the rate of change between the revised integrated state parameter and the original integrated state parameter;

According to the change rate and the parameter value of the corrected comprehensive state parameter, it is determined that the sensor is in an attenuation state, and the steady state output current of the sensor is corrected by using the corrected comprehensive state parameter.
The method according to claim 5, wherein determining that the sensor is in an attenuation state according to the rate of change and the parameter value of the corrected comprehensive state parameter comprises:

If the rate of change is in the first threshold interval and the corrected comprehensive state parameter is smaller than the second threshold interval, then the sensor is in an attenuation state.
A continuous blood sugar correction device, characterized in that it comprises:

The collection module is used to separately collect the transient output current and steady-state output current of the sensor according to the set calibration cycle;

A determination module, configured to determine the sensitivity coefficient of the sensor according to the current value and variation characteristics of the transient output current;

An execution module, configured to correct the steady-state output current according to the sensitivity coefficient, and determine the blood glucose level based on the corrected steady-state output current.
The device according to claim 7, wherein the device further comprises:

A power module, the transient output current is output when the power module applies a transient voltage to the sensor, and the steady-state output current is output when the power module applies a steady-state voltage to the sensor;

Wherein, the voltage value of the transient voltage changes with time and the voltage waveform of the transient voltage includes any one or more of the following combinations: square wave; pulse wave; triangular wave; step wave; trapezoidal wave; linear wave ; white noise wave; sine wave.
The device according to claim 7, wherein the execution module is specifically used for:

Correcting the original comprehensive state parameter of the sensor according to the sensitivity coefficient;

The steady-state output current of the sensor is corrected by using the corrected comprehensive state parameters.
The device according to claim 9, wherein the device further comprises:

The temperature detection module is used to detect the human body temperature in the current test environment;

The execution module is specifically configured to determine a state correction value according to the human body temperature and the sensitivity coefficient; and use the state correction value to correct the original comprehensive state parameters of the sensor.
The device according to claim 10, wherein the execution module is specifically used for:

determining the rate of change between the revised integrated state parameter and the original integrated state parameter;

According to the change rate and the parameter value of the corrected comprehensive state parameter, it is determined that the sensor is in an attenuation state, and the steady state output current of the sensor is corrected by using the corrected comprehensive state parameter.
The device according to claim 11, wherein the rate of change is in a first threshold interval and the corrected comprehensive state parameter is smaller than a second threshold interval, then the execution module determines that the sensor is in an attenuation state .
An electronic device, characterized in that it comprises:

at least one processor; and at least one memory communicatively coupled to the processor, wherein:

The memory stores program instructions executable by the processor, and the processor can execute the method according to any one of claims 1 to 6 by calling the program instructions.
A computer-readable storage medium, characterized in that the computer-readable storage medium stores computer instructions, and the computer instructions cause the computer to execute the method according to any one of claims 1 to 6.