WO2023011493A1

WO2023011493A1 - Double-blind experimental apparatus, electronic device, double-blind experimental system, and storage medium

Info

Publication number: WO2023011493A1
Application number: PCT/CN2022/109773
Authority: WO
Inventors: 周国新; 唐建东; 王倩; 姚晨
Original assignee: 苏州景昱医疗器械有限公司
Priority date: 2021-08-03
Filing date: 2022-08-02
Publication date: 2023-02-09
Also published as: CN113593660A

Abstract

The present application provides a double-blind experimental apparatus, an electronic device, a double-blind experimental system, and a storage medium. The apparatus comprises: an information acquisition module acquiring grouping information of multiple experimental subjects; an execution receiving module receiving, using experimental equipment, an execution operation on a target experimental subject, the execution operation being used for indicating an identification and parameter value of an execution parameter; a group acquisition module acquiring, in response to the execution operation, the group of the target experimental subject on the basis of the grouping information of the multiple experimental subjects; a real execution module, when the group of the target experimental subject is a first group, executing a first action on the target experimental subject on the basis of the execution operation; and a simulation execution module, when the group of the target experimental subject is a second group, not executing any action on the target experimental subject, or controlling an execution mechanism to execute a second action on the target experimental subject. The present application solves the problem that experimental apparatuses used by different double-blind experiments are different and cannot be used in common with each other.

Description

Double-blind experimental device, electronic equipment, double-blind experimental system and storage medium

This application claims the priority of the Chinese patent with application number 202110887107.2 filed on August 3, 2021, which is incorporated by reference in its entirety.

technical field

The present application relates to the technical field of data processing, in particular to a double-blind experiment device, electronic equipment, a double-blind experiment system and a storage medium.

Background technique

A double-blind experiment means that neither the tester nor the testee knows the group (experimental group or control group) the testee belongs to during the experiment, and the analyst usually does not know that the data being analyzed belongs to the group (experimental group or control group). which group. This double-blind experiment aims to eliminate subjective bias and personal preference that may appear in the consciousness of experimenters and participants. In most cases, double-blind experiments require a very high degree of scientific rigor.

In the prior art, different double-blind experiments perform various actions. For example, in the electrical stimulation double-blind experiment, the stimulator stimulates the experimental group. For the control group, no electrical stimulation is performed. In the experiment, the experimental group was given drugs or health care products, and the control group was given a placebo. In the double-blind experiment of electromagnetic waves, the experimental group was irradiated with electromagnetic waves, and the control group was not irradiated with electromagnetic waves; different double-blind experiments used The experimental devices are not the same and cannot be used with each other, resulting in a waste of resources. Therefore, it is particularly important to develop an experimental device that can be used for various types of double-blind experiments for the development and verification of methods, drugs, and methods.

Contents of the invention

The purpose of this application is to provide double-blind experimental devices, electronic equipment, double-blind experimental systems and storage media, to solve the problem that the experimental devices used in different double-blind experiments are not the same and cannot be used in common with each other, resulting in the waste of resources. .

The purpose of this application adopts following technical scheme to realize:

In a first aspect, the present application provides a double-blind experimental method, the method comprising: acquiring grouping information of multiple experimental subjects, the grouping information of the experimental subjects being used to indicate that the group of the experimental subjects is the first group or the second group; using the experimental equipment to receive an execution operation on the target experiment subject, the target experiment object being one of the plurality of experiment subjects, the execution operation being used to indicate the identity and parameter value of the execution parameter; In response to the execution operation, based on the grouping information of the plurality of test subjects, the group of the target test subjects is obtained; when the group of the target test subjects is the first group, the control executive mechanism based on The execution operation executes the first action on the target test subject; when the group of the target test subject is the second group, does not perform any action on the target test subject, or controls the execution mechanism to The target subject performs a second action; wherein the first action and the second action are indistinguishable by the target subject.

The beneficial effect of this technical solution is: using the experimental equipment to receive the execution operation of the identification and parameter value of the target experiment object for indicating the execution parameter, in response to the execution operation, based on the grouping information of the plurality of experiment objects, obtain The group of the target test subject, when the target test subject is the first group, perform the first action on the target test subject, and when the target test subject is the second group, do not perform any action on the target test subject, or control The executive mechanism executes the second action on the target experiment object; thus, in a double-blind experiment device, different types of double-blind experiments can be commonly performed and resources are saved. In addition, the experimental equipment is used to receive the execution operation, so as to determine the identification and parameter value of the execution parameter, and control the execution mechanism to perform corresponding operations or not to perform operations, thereby achieving the purpose of precisely controlling the execution mechanism. include

In a possible implementation manner, the method further includes: when the group of the target subject is the first group, receiving real feedback information sent by the actuator as the target feedback information; When the group of the target experiment object is the second group, generate simulation feedback information as the target feedback information based on the identifier and parameter value of the execution parameter; and send the target feedback information to the experimental equipment. The beneficial effect of this technical solution is that: when the target experiment object is the first group, the real feedback information sent by the actuator is received as the target feedback information; The simulated feedback information is used as the target feedback information, and the target feedback information is sent to the experimental equipment, thereby realizing the blinding of the experimenters when using the interactive experimental equipment for experiments, ensuring that the experimental equipment of the interactive experimental equipment The results are scientific; the simulation feedback information is generated based on the identification and parameter values of the execution parameters, so that the generated simulation feedback information is closer to the feedback results obtained in the real experimental environment, and further enhances the blinding effect of the experimenters.

In a possible implementation manner, the sending the target feedback information to the experimental equipment includes: causing the experimental equipment to display the target feedback information in real time. The beneficial effect of the technical solution is that the target feedback information is displayed in real time, which is beneficial for the experimenters to obtain the feedback information in time, and facilitates the experimenters to adjust the parameters in time.

In a possible implementation manner, the acquiring the grouping information of the multiple experimental subjects includes: using the experimental equipment to receive a synchronization operation; in response to the synchronization operation, acquiring the information of the multiple experimental subjects from the storage device The grouping information is stored in the double-blind experimental device. The beneficial effect of this technical solution is that: in response to the received synchronous operation, the grouping information of multiple experimental objects is obtained from the storage device, which can avoid the risk of possible leakage of grouping information caused by obtaining the grouping information in advance, and at the same time, the grouping information can be obtained before the experiment starts. The synchronous operation is performed to obtain group information, which ensures the real-time performance of obtaining group information.

In a possible implementation manner, in response to the execution operation, after obtaining the group of the target experimental subject based on the grouping information of the plurality of experimental subjects, the method further includes: combining the two The grouping information of the multiple experimental subjects stored by the blind experiment device is deleted. The beneficial effect of the technical solution is that: after the group of the target subject is acquired, the group information is deleted, further avoiding the risk of the group information being leaked due to the long storage time of the group information.

In a possible implementation manner, the method further includes: using experimental equipment to receive an unblinding operation on the target subject, where the unblinding operation is normal unblinding or emergency unblinding; responding to the unblinding Operation, using the experimental equipment to display the groups of the target experimental subjects. The beneficial effect of the technical solution is that: after receiving the unblinding operation, the experiment equipment is used to display the group of the target experiment subject, so that the group of the target experiment subject can be displayed at an appropriate time.

In a possible implementation manner, the unblinding operation is normal unblinding, and in response to the unblinding operation, using the experimental equipment to display the group of the target experimental subjects includes: obtaining experimental status information , the experimental state information is used to indicate whether the double-blind experiment has been completed; when the experimental state information indicates that the double-blind experiment has not been completed, the experimental equipment is used to display the unblinding confirmation page; when the experimental equipment When receiving a confirmation unblinding operation, using the experimental equipment to display the group of the target experimental subject; the method further includes: when the experimental equipment receives a rejection unblinding operation, generating first rejection information and The first rejection information is sent to the experimental equipment, so that the experimental equipment displays the first rejection information. The beneficial effect of this technical solution is: when requesting normal unblinding, it is judged whether the double-blind experiment has been completed; when the double-blind experiment is not completed, the experimental equipment is used to display the unblinding confirmation page; , when the rejection of the unblinding operation is received, the first rejection information is generated and sent to the experimental equipment, thereby preventing normal unblinding when the experiment is not completed due to misoperation.

In a possible implementation, the unblinding operation is emergency unblinding, and in response to the unblinding operation, using the experimental equipment to display the group of the target experimental subjects includes: obtaining the experimental The identity authority information of the experimenter corresponding to the device, the identity authority information is used to indicate whether the experimenter has emergency unblinding authority; when the identity authority information indicates that the experimenter has emergency unblinding authority, use the The experimental equipment displays the group of the target experimental subject; the method further includes: when the identity authority information indicates that the experimenter does not have emergency unblinding authority, generating second rejection information and sending the second rejection information sent to the experimental equipment, so that the experimental equipment displays the second rejection information. The beneficial effect of this technical solution is: when requesting emergency unblinding, verify whether the experimenter corresponding to the experimental equipment has emergency unblinding authority; 2. Reject the information and send it to the experimental equipment; thus, verifying the emergency unblinding authority can ensure that the experimenters who have the emergency unblinding authority can perform emergency unblinding, and at the same time prevent misuse by those who do not have the emergency unblinding authority. Emergency unblinding.

In a second aspect, the present application provides a double-blind experimental device, the double-blind experimental device includes: an information acquisition module, configured to acquire grouping information of a plurality of experimental subjects, and the grouping information of the experimental subjects is used to indicate the The group of the experimental subjects is the first group or the second group; the execution receiving module is configured to use the experimental equipment to receive the execution operation on the target experimental subject, and the target experimental subject is one of the plurality of experimental subjects, The execution operation is used to indicate the identity and parameter value of the execution parameter; the group acquisition module is configured to acquire the group of the target experiment object based on the grouping information of the plurality of experiment objects in response to the execution operation; The real execution module is used to control the execution mechanism to perform the first action on the target experiment object based on the execution operation when the group of the target experiment object is the first group; the simulation execution module is used to perform the first action on the target experiment object when When the group of the target test subject is the second group, do not perform any action on the target test subject, or control the actuator to perform a second action on the target test subject; wherein, the first Motion and said second motion are indistinguishable by said target subject.

In a possible implementation manner, the double-blind experimental device further includes: a real feedback module, configured to receive real feedback information sent by an actuator when the group of the target experimental subject is the first group As the target feedback information; a simulated feedback module, configured to generate simulated feedback information as the target feedback based on the identifier and parameter value of the execution parameter when the group of the target subject is the second group Information; a feedback sending module, configured to send the target feedback information to the experimental equipment.

In a possible implementation manner, the feedback sending module further includes: a feedback display module, configured to enable the experimental equipment to display the target feedback information in real time.

In a possible implementation manner, the information acquisition module includes: a synchronization operation unit, configured to use the experimental equipment to receive a synchronization operation; a grouping information unit, configured to obtain the information from the storage device in response to the synchronization operation The grouping information of the multiple experimental subjects is stored in the double-blind experimental device.

In a possible implementation manner, the double-blind experimental device further includes: an information deletion module, configured to delete the grouping information of the plurality of experimental subjects stored in the double-blind experimental device.

In a possible implementation manner, the double-blind experimental device further includes: an unblinding receiving module, configured to use experimental equipment to receive an unblinding operation on the target experimental subject, and the unblinding operation is normal unblinding or Unblinding urgently; an information display module, configured to display the group of the target experimental subjects by using the experimental equipment in response to the unblinding operation.

In a possible implementation manner, the unblinding operation is normal unblinding, and the information display module includes: an experimental status unit, configured to obtain experimental status information, and the experimental status information is used to indicate that the double-blind experiment Whether it has been completed; the unblinding confirmation unit is used to display the unblinding confirmation page by using the experimental equipment when the experimental status information indicates that the double-blind experiment is not completed; the group display unit is used when the experimental equipment When receiving the determined unblinding operation, use the experimental equipment to display the group of the target experimental subjects; the double-blind experimental device also includes: a first rejection module, used to reject the unblinding operation when the experimental equipment receives , generating first rejection information and sending the first rejection information to the experimental device, so that the experimental device displays the first rejection information.

In a possible implementation manner, the unblinding operation is emergency unblinding, and the information display module includes: an authority acquisition unit, configured to acquire the identity authority information of the experimenter corresponding to the experimental equipment, and the identity authority The information is used to indicate whether the experimenter has emergency unblinding authority; the emergency unblinding unit is used to display the target experiment by using the experimental equipment when the identity authority information indicates that the experimenter has emergency unblinding authority. The group of objects; the double-blind experimental device also includes: a second rejection module, used to generate second rejection information and transfer the first The second rejection information is sent to the experimental equipment, so that the experimental equipment displays the second rejection information.

In a third aspect, the present application provides an electronic device, the electronic device includes a memory and a processor, the memory stores a computer program, and the processor implements the following steps when executing the computer program:

Acquiring grouping information of multiple experimental subjects, where the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group;

Using the experimental device to receive an execution operation on a target experimental subject, the target experimental subject being one of the plurality of experimental subjects, the execution operation being used to indicate the identity and parameter value of the execution parameter;

Responsive to the execution operation, based on the grouping information of the plurality of test subjects, acquire the group of the target test subjects;

When the group of the target subject is the first group, receiving the real feedback information sent by the actuator as the target feedback information;

When the group of the target subject is the second group, generating simulated feedback information as the target feedback information based on the identifier of the execution parameter and the parameter value;

sending the target feedback information to the experimental equipment, so that the experimental equipment displays the target feedback information.

In a fourth aspect, the present application provides a double-blind experimental system, which is characterized in that the double-blind experimental system includes experimental equipment, an actuator, and the electronic device provided in the third aspect of the present application.

In a possible implementation manner, the experimental equipment is that the experimental equipment is a program-controlled equipment, and the actuator is a stimulator arranged in the body of the target experimental subject; the processor is also used to When the group is the first group, control the actuator to apply electrical stimulation based on the execution operation, and receive the real feedback information sent by the actuator as the target feedback information; and when the group of the target subject is In the second group, the actuator is controlled not to apply electrical stimulation. The beneficial effect of the technical solution lies in that the double-blind experiment is carried out by using the program controller and the stimulator, and the experimenter is blinded during the interactive program-controlled electrical stimulation process.

In a possible implementation manner, the experimental equipment is a drug dispensing control equipment, and the actuator includes a manipulator and a sensor; The execution operation controls the manipulator to distribute the first type of medicine to the target subject, and receives the real feedback information sent by the sensor as the target feedback information; and when the group of the target subject is the second group , controlling the manipulator to distribute the second type of medicine to the target subject. The beneficial effect of the technical solution lies in that: the double-blind experiment is carried out by using the drug dispensing control device and the executive mechanism, and the experimenters are blinded in the interactive drug dispensing process.

In a possible implementation manner, the experimental equipment is electromagnetic wave control equipment, and the actuator includes an electromagnetic wave generating device and an electromagnetic wave detecting device; the processor is also used to , controlling the electromagnetic wave generating device to transmit electromagnetic waves to the target subject based on the execution operation, and receiving the real feedback information sent by the electromagnetic wave detection device as the target feedback information; and when the group of the target subject is the first In the second group, the electromagnetic wave generating device is controlled not to emit electromagnetic waves to the target experiment subject; wherein, when the target experiment subject is a human being, whether the electromagnetic wave is emitted cannot be distinguished by the target experiment subject. The beneficial effect of the technical solution is that: the double-blind experiment is carried out by using the electromagnetic wave control equipment and the actuator, and the experimenter is blinded during the interactive electromagnetic wave emission process.

In a fifth aspect, the present application provides a computer-readable storage medium, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the following steps are implemented:

Acquiring the grouping information of a plurality of experimental subjects, the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group; using the experimental equipment to receive the execution operation on the target experimental subject, the The target experiment object is one of the plurality of experiment objects, and the execution operation is used to indicate the identifier and parameter value of the execution parameter; in response to the execution operation, based on the grouping information of the plurality of experiment objects, obtain the the group of the target experiment object; when the group of the target experiment object is the first group, the control actuator executes the first action on the target experiment object based on the execution operation; when the target experiment object When the group of subjects is the second group, do not perform any action on the target test subject, or control the actuator to perform a second action on the target test subject; wherein, the first action and the The second movement cannot be discerned by the target subject.

Description of drawings

The application will be further described below in conjunction with the accompanying drawings and embodiments.

Fig. 1 is a schematic flow chart of a double-blind experimental method provided in the embodiment of the present application;

Fig. 2 is a partial flow diagram of another double-blind experimental method provided in the embodiment of the present application;

Fig. 3 is a partial flow diagram of another double-blind experimental method provided in the embodiment of the present application;

Fig. 4 is a schematic flow diagram of obtaining grouping information of multiple experimental subjects provided by the embodiment of the present application;

Fig. 5 is a partial flow diagram of another double-blind experimental method provided in the embodiment of the present application;

Fig. 6 is a partial flowchart of another double-blind experimental method provided in the embodiment of the present application;

Fig. 7 is a schematic flow chart of using experimental equipment to display groups of target experimental subjects provided by the embodiment of the present application;

Fig. 8 is a partial flowchart of another double-blind experimental method provided in the embodiment of the present application;

Fig. 9 is another schematic flow diagram of using experimental equipment to display groups of target experimental subjects provided by the embodiment of the present application;

Fig. 10 is a partial flowchart of another double-blind experimental method provided in the embodiment of the present application;

Figure 11 is a schematic structural view of a double-blind experimental device provided in the embodiment of the present application;

Figure 12 is a partial structural schematic diagram of another double-blind experimental device provided in the embodiment of the present application;

Fig. 13 is a partial structural schematic diagram of another double-blind experimental device provided in the embodiment of the present application;

FIG. 14 is a schematic structural diagram of an information acquisition module provided by an embodiment of the present application;

Fig. 15 is a partial structural schematic diagram of another double-blind experimental device provided in the embodiment of the present application;

Fig. 16 is a partial structural schematic diagram of another double-blind experimental device provided in the embodiment of the present application;

Fig. 17 is a schematic structural diagram of an information display module provided by an embodiment of the present application;

Figure 18 is a partial structural schematic diagram of another double-blind experimental device provided in the embodiment of the present application;

Fig. 19 is a schematic structural diagram of another information display module provided by the embodiment of the present application;

Fig. 20 is a partial structural schematic diagram of another double-blind experimental device provided in the embodiment of the present application;

Fig. 21 is a schematic structural diagram of an electronic device provided by an embodiment of the present application;

Fig. 22 is a schematic structural diagram of a double-blind experimental system provided in the embodiment of the present application;

FIG. 23 is a schematic structural diagram of a program product for implementing a double-blind experiment method provided by an embodiment of the present application.

Detailed ways

Below, the present application will be further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, on the premise of not conflicting, the various embodiments described below or the technical features can be combined arbitrarily to form a new embodiment. .

In the embodiments of the present application, "at least one" means one or more, and "multiple" means two or more. "And/or" describes the association relationship of associated objects, indicating that there may be three types of relationships, for example, A and/or B, which can mean: A exists alone, A and B exist simultaneously, and B exists alone, where A, B can be singular or plural. The character "/" generally indicates that the contextual objects are an "or" relationship. "At least one of the following" or similar expressions refer to any combination of these items, including any combination of single or plural items. For example, at least one item (piece) of a, b or c can represent: a, b, c, a and b, a and c, b and c or a and b and c, wherein a, b and c can be It can be single or multiple. It should be noted that "at least one item (item)" can also be interpreted as "one item (item) or multiple items (item)".

In the embodiments of the present application, words such as "exemplary" or "for example" are used as examples, illustrations or descriptions. Any embodiment or design described herein as "exemplary" or "for example" is not to be construed as preferred or advantageous over other embodiments or designs. Rather, the use of words such as "exemplary" or "such as" is intended to present related concepts in a concrete manner.

In the following, one of the application fields (ie, implantable devices) of the embodiments of the present application will be briefly described first.

An implantable neurostimulation system (an implantable medical system) mainly includes a stimulator implanted in the patient's body and a program-controlled device installed outside the patient's body. The existing neuromodulation technology mainly uses stereotaxic surgery to implant electrodes in specific structures (i.e., targets) in the body, and the stimulator implanted in the patient sends electrical pulses to the targets through the electrodes to regulate the corresponding neural structures and networks. Electrical activity and its function, thereby improving symptoms and relieving pain. Among them, the stimulator can be an implantable electrical nerve stimulation device, an implantable cardiac electrical stimulation system (also known as a cardiac pacemaker), an implantable drug infusion device (Implantable Drug Delivery System, referred to as IDDS) and a wire switch. any one of the connected devices. Implantable electrical nerve stimulation devices are, for example, Deep Brain Stimulation (DBS), Implantable Cortical Nerve Stimulation (CNS), Implantable Spinal Cord Stimulation , referred to as SCS), implanted sacral nerve stimulation system (Sacral Nerve Stimulation, referred to as SNS), implanted vagus nerve stimulation system (Vagus Nerve Stimulation, referred to as VNS), etc.

The stimulator can include IPG, extension wires and electrode wires. The IPG (implantable pulse generator, implantable pulse generator) is set in the patient's body, receives the program control instructions sent by the program control device, and provides controllable stimulation to the tissues in the body relying on sealed batteries and circuits. Electrical stimulation energy, through implanted extension leads and electrode leads, delivers one or two controlled, specific electrical stimuli to specific areas of tissue in the body. The extension lead is used in conjunction with the IPG as a transmission medium for the electrical stimulation signal, and transmits the electrical stimulation signal generated by the IPG to the electrode lead. Electrode leads deliver electrical stimulation to specific areas of tissue in the body through multiple electrode contacts. The stimulator is provided with one or more electrode wires on one side or both sides, and a plurality of electrode contacts are arranged on the electrode wires, and the electrode contacts can be arranged uniformly or non-uniformly in the circumferential direction of the electrode wires. As an example, the electrode contacts may be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) in the circumferential direction of the electrode wire. Electrode contacts may include stimulation electrode contacts and/or collection electrode contacts. The electrode contacts can be in the shape of, for example, a sheet, a ring, or a dot.

In some possible implementations, the stimulated body tissue may be the patient's brain tissue, and the stimulated site may be a specific part of the brain tissue. When the patient's disease type is different, the stimulated site is generally different, the number of stimulation contacts used (single source or multi-source), one or more channels (single-channel or multi-channel) specific electrical stimulation signals The application and stimulus parameter data are also different. The embodiment of the present application does not limit the applicable disease types, which may be the applicable disease types for deep brain stimulation (DBS), spinal cord stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. Among the types of disorders that DBS can be used to treat or manage include, but are not limited to: spasticity disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety disorders, Post-traumatic stress disorder, hypodepression, obsessive-compulsive disorder (OCD), conduct disorder, mood disorder, memory disorder, mental status disorder, mobility disorder (eg, essential tremor or Parkinson's disease), Huntington's disease, Al Alzheimer's disease, drug addiction, autism, or other neurological or psychiatric conditions and impairments.

In the embodiment of the present application, when the program-controlled device and the stimulator establish a program-controlled connection, the program-controlled device can be used to adjust the stimulation parameters of the stimulator (different stimulation parameters correspond to different electrical stimulation signals), and the stimulator can also be used to sense the deep brain of the patient. The bioelectric activity of the stimulator can be used to collect the electrophysiological signal, and the stimulation parameters of the electrical stimulation signal of the stimulator can be adjusted continuously through the collected electrophysiological signal.

Stimulation parameters can include at least one of the following: frequency (for example, the number of electrical stimulation pulse signals per unit time 1s, the unit is Hz), pulse width (the duration of each pulse, the unit is μs), amplitude (generally used Voltage expression, that is, the intensity of each pulse, the unit is V), timing (for example, it can be continuous or triggered), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode and cycle stimulation mode) , The upper and lower limits of the doctor's control (the range that can be adjusted by the doctor) and the upper and lower limits of the patient's control (the range that can be adjusted by the patient).

In a specific application scenario, various stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.

The program-controlled device may be a doctor-programmed device (ie, a program-controlled device used by a doctor) or a patient-programmed device (ie, a program-controlled device used by a patient). The doctor's program-controlled device can be, for example, a tablet computer, a notebook computer, a desktop computer, a mobile phone and other smart terminal devices equipped with program-controlled software. The patient program-controlled device can be, for example, smart terminal devices such as tablet computers, notebook computers, desktop computers, and mobile phones equipped with program-controlled software, and the patient program-controlled device can also be other electronic devices with program-controlled functions (such as chargers with program-controlled functions, data collection device).

The embodiment of the present application does not limit the data interaction between the doctor's program-controlled device and the stimulator. When the doctor remotely programs, the doctor's program-controlled device can perform data interaction with the stimulator through the server and the patient's program-controlled device. When the doctor performs program control with the patient face-to-face offline, the doctor's program-controlled device can interact with the stimulator through the patient's program-controlled device, and the doctor's program-controlled device can also directly interact with the stimulator.

In some optional embodiments, the patient programmable device may include a host (communicating with the server) and a slave (communicating with the stimulator), the host and slave being communicatively connected. Among them, the doctor's program-controlled equipment can exchange data with the server through the 3G/4G/5G network, the server can exchange data with the host through the 3G/4G/5G network, and the host can exchange data with the slave through the Bluetooth protocol/WIFI protocol/USB protocol. Interaction, the sub-machine can exchange data with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band, and the doctor's program-controlled equipment can directly exchange data with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band interact.

In addition to the above-mentioned application fields of implantable devices, the embodiments of the present application can also be applied to the technical fields of other medical devices or even non-medical devices. The embodiments of the present application are not limited to this, as long as it involves double-blind experiments, it can be applied, and The instructions sent by the program-controlled device to the stimulator may not be limited to program-controlled instructions.

Referring to FIG. 1 , the embodiment of the present application provides a double-blind experimental method, which includes steps S101-S105.

Step S101: Obtain grouping information of a plurality of experimental subjects, the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group.

Wherein, the manner of obtaining the grouping information of multiple experimental subjects may include obtaining from a storage device, or manually entering by a third-party staff. The grouping information of multiple experimental subjects may be text information, such as "Zhang San, the control group; Li Si, the experimental group", or table information, such as a table including the names of multiple experimental subjects and the groups they belong to. The experimental subjects can be humans or animals.

Step S102: Utilize the experimental device to receive an execution operation on a target experiment object, the target experiment object being one of the plurality of experiment objects, and the execution operation is used to indicate the identifier and parameter value of the execution parameter.

Among them, the experimental equipment may include desktop computers, notebook computers, tablet computers, mobile phones, smart wearable devices, etc. used in the double-blind experiment; the execution operation may be the operation of inputting text information on the experimental equipment, for example, "Apply a voltage of 0.1 to Zhang San. mv duration of 30s ", the execution operation can also be to select one of the multiple execution operation options provided by the experimental equipment as the operation on the target experimental object; the identification of the execution parameters is, for example: "electric stimulation", " For example, "medication", "infrared light irradiation", etc., the parameter values of the execution parameters are: "voltage 0.1mv, duration 30s", "administration of 5 grams", "infrared light irradiation 1min" and so on.

Step S103: In response to the execution operation, based on the grouping information of the plurality of experimental subjects, the group of the target experimental subjects is acquired.

Step S104: When the group of the target experiment subject is the first group, the control actuator executes a first action on the target experiment subject based on the execution operation.

Wherein, performing the first action is, for example, applying a voltage of 0.11mv to the target subject for electrical stimulation for 29s, or administering 5 grams of medicine to the target subject, or irradiating the target subject with infrared light for 59s.

Step S105: When the group of the target test subject is the second group, do not perform any action on the target test subject, or control the actuator to perform a second action on the target test subject; wherein, The first motion and the second motion are indistinguishable by the target subject.

That is, the target subject cannot distinguish between the first action and the second action.

Wherein, the second action is, for example, giving 5 grams of placebo to the target subject; wherein, the medicine or health product used by the placebo and the experimental group has the same shape, size, color, and taste, and the target subject cannot distinguish Placebos and actual medicines or supplements.

Thus, the experimental device receives an execution operation on the target experimental object indicating the identifier of the execution parameter and the parameter value, and in response to the execution operation, based on the grouping information of the plurality of experimental objects, the target experimental object is acquired When the target test subject is the first group, perform the first action on the target test subject, and when the target test subject is the second group, do not perform any action on the target test subject, or control the actuator to The target experiment subject performs the second action; thus, in a double-blind experiment device, different types of double-blind experiments can be commonly performed and resources are saved.

Continuing to refer to FIG. 1, in some possible manners, the method may further include step S101: acquiring grouping information of multiple experimental subjects, the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or second group.

Continuing to refer to FIG. 1 , in some possible manners, the step S103 may include: in response to the execution operation, based on the grouping information of the plurality of experimental subjects, acquiring a group of the target experimental subjects.

In a specific application scenario, the experimental equipment is a tablet computer used for remote program control, and the actuator is a stimulator installed in the subject’s body. A double-blind experiment is carried out to obtain the group information of Zhang San and Li Si. The group information is: "Zhang San, the control group; Li Si, the experimental group", use the tablet computer to receive electrical stimulation on Zhang San, and the execution operation instruction: "Apply electrical stimulation to Zhang San with a voltage of 0.1mv and a duration of 30s", and respond In this execution operation, Zhang San’s group was obtained as the control group, and Zhang San was not given electrical stimulation; the tablet computer was used to receive the electrical stimulation of Li Si to execute the operation. In response to the execution operation, the group of Li Si was obtained as the experimental group. Based on the above execution operation instruction, the control actuator based on the execution operation instruction "applied a voltage of 0.1mv to Li Si for a duration of 30s. "Electric Stimulation" applied electrical stimulation to Li Si, but due to errors, the actual applied voltage was 0.09mv, and the actual duration of the voltage was 31s; Wu and Zhao Liu conducted a double-blind experiment on weight-loss health products. Wang Wu was the control group, and Zhao Liu was the experimental group. At this time, the manipulator distributed placebo to Wang Wu and experimental health products to Zhao Liu. The shape, size, color, and taste of the health care products used were the same, so that Wang Wu and Zhao Liu could not distinguish the placebo from the experimental health care products. Combining the two specific application scenarios, it can be clarified that the double-blind experiment method can be generally used for different types of double-blind experiments.

Due to error or precision, in the actual execution process of the actuator, there will be deviations between the actual value of the corresponding execution parameter and the parameter value of the execution parameter indicated by the execution operation, so feedback information needs to be provided. Referring to FIG. 2 , in some possible manners, the method may further include: steps S106-S108.

Step S106: When the group of the target subject is the first group, receive the real feedback information sent by the actuator as the target feedback information.

Among them, the real feedback information is used to indicate the performance of the actuator, for example: "electrical stimulation with an applied voltage of 0.11mv" can also be the feedback information collected by the sensor or electromagnetic wave detection device installed in the actuator, such as "5 grams have been successfully administered" or "successfully irradiated with infrared light for 58s". In practical applications, due to error or precision, in the actual execution process of the actuator, there will be deviations between the actual value of the corresponding execution parameter and the parameter value of the execution parameter indicated by the execution operation. Therefore, the actuator needs to be The resulting parameters of the actual execution are fed back to the experimenter. The feedback information may include at least one of the following: text information, voice information, picture information and video information.

Step S107: When the group of the target subject is the second group, generate simulation feedback information as the target feedback information based on the identifier and parameter value of the execution parameter.

Wherein, the analog feedback information is generated based on the identification and parameter value of the execution parameter as the target feedback information, for example: the identification and parameter value of the execution parameter are: "apply electrical stimulation with a voltage of 0.1mv to Zhang San and a duration of 30s ", the generated analog feedback information is: "A voltage of 0.11mv has been successfully applied to Zhang San, and the electrical stimulation lasts for 29s", or, when the identifier and parameter value of the execution parameter are: "5g is administered to Li Si", The generated simulated feedback information is: "5g has been successfully administered to Li Si", or, when the identifier and parameter value of the execution parameter are: "Irradiate Wang Wu with infrared light for 1 minute", the generated simulated feedback information is: "has been administered Successfully irradiated Wang Wuge with infrared light for 59 seconds."

Step S108: Send the target feedback information to the experimental equipment.

Wherein, the experimental equipment displaying the target feedback information may be to generate a simulation effect image, and the simulation effect image is used to indicate the parameter value in the target feedback information, for example, it may be in the form of waveform, cloud, etc., to simulate the electrical stimulation process. The electric field strength, impedance, amplitude, range of action, and divergence effect of the electrode electric field. The waveforms, clouds, etc. vary with the changes in the electric field strength, impedance, amplitude, range of action, and divergence effect of the electrode electric field during the simulated electrical stimulation process. . When the actuator includes multiple stimulating electrodes, the simulation effect image includes images of multiple stimulating electrodes. When one of the electrodes is selected, the image corresponding to the electrode changes, for example, the image corresponding to the electrode becomes highlighted, Alternatively, a luminous effect is generated around the image corresponding to the electrode.

Therefore, when the target experiment object is the first group, the real feedback information sent by the actuator is received as the target feedback information; Describe the target feedback information, and send the target feedback information to the experimental equipment; thus, it is realized that the experimenter is blinded when using the interactive experimental equipment to conduct experiments, and the scientificity of the experimental results of the interactive experimental equipment is ensured; The simulation feedback information is generated based on the identification of the execution parameters and the parameter value, so that the generated simulation feedback information is closer to the feedback results obtained in the real experimental environment, and further enhances the blinding effect on the experimenters.

In a specific application scenario, the experimental equipment is a tablet computer used for remote program control, and the actuator is a stimulator installed in the subject’s body. A double-blind experiment is carried out to obtain the group information of Zhang San and Li Si. The group information is: "Zhang San, the control group, Li Si, the experimental group", use the tablet computer to receive the electrical stimulation operation on Zhang San, the execution operation instruction: "Apply electrical stimulation with a voltage of 0.1mv to Zhang San, and the duration is 30s", the response For this execution operation, obtain Zhang San’s group as the control group, and based on the above execution operation instructions, generate simulated feedback information “successfully applied electrical stimulation with a voltage of 0.11mv to Zhang San for a duration of 29s”, and transfer the real feedback information Send the target feedback information to the tablet computer so that the tablet computer displays the target feedback information; in another specific application scenario, the grouping information is the same as the above application scenario, and the tablet computer is used to receive the electrical stimulation of Li Si to perform the operation. Instruction: "Apply a voltage of 0.1mv to Li Si for electrical stimulation with a duration of 30s", in response to the execution operation, obtain Li Si's group as the experimental group, based on the above execution operation instruction, control the actuator based on the execution operation instruction" Apply electrical stimulation to Li Si with a voltage of 0.1mv and a duration of 30s"Apply electrical stimulation to Li Si, but due to errors, the actual applied voltage is 0.09mv, the actual duration of the voltage is 31s, and the real feedback sent by the actuator is received The information "has successfully applied electrical stimulation with a voltage of 0.09mv and a duration of 31s to Li Si", and the real feedback information is sent to the tablet computer as the target feedback information to make the tablet computer display the target feedback information; since the simulated feedback information is different from the real The feedback information is all within the error range, so the two kinds of feedback information cannot be distinguished, thus realizing the blinding of the experimenters in the interactive experimental equipment.

Referring to FIG. 3 , in some possible manners, the method may further include step S109.

Step S109: Make the experimental equipment display the target feedback information in real time.

Therefore, real-time display of target feedback information is beneficial for experimenters to obtain feedback information in a timely manner, and facilitates experimenters to adjust parameters in time.

In a specific application scenario, the experimenter performed electrical stimulation on Zhang San. Due to an operation error, the experimenter changed the input value of the 0.1mv electrical stimulation that should have been applied to 0.15mv. When the real feedback information obtained through the experimental equipment was 0.144 mv, the experimenter found an error and changed the input value to 0.1mv.

Referring to Fig. 4, in some possible manners, the step S101 may include steps S201-S202.

Step S201: Use the experimental equipment to receive a synchronous operation.

Wherein, the way for the experimental equipment to receive the synchronous operation may be to set a physical synchronous operation button on the experimental equipment, and to receive the synchronous operation in response to the physical synchronous operation button being touched; or, to set the synchronous operation option on the display screen of the experimental equipment, and respond When the sync operation option is clicked, the sync operation is received.

Step S202: In response to the synchronization operation, obtain grouping information of the plurality of experimental subjects from a storage device and store them in the double-blind experimental device.

Therefore, in response to the received synchronization operation, the grouping information of multiple experimental objects is obtained from the storage device, which can avoid the risk of group information leakage caused by obtaining the grouping information in advance, and at the same time, the synchronization operation can be performed before the experiment starts, and the grouping information can be obtained. Group information ensures the real-time performance of obtaining group information.

In a specific application scenario, the experimental equipment is a tablet computer, and the tablet computer has a "synchronization" option. Click the "synchronization" option, and the experimental equipment receives the synchronization operation. At this time, the data of multiple experimental objects is obtained from the storage device. Grouping information, because the grouping information is obtained after receiving the synchronization operation, avoiding the risk of grouping information leakage caused by obtaining the grouping information in advance. When the group information changes, it can be synchronized to update the latest group information in real time.

Referring to FIG. 5 , in some possible manners, after the step S103, the double-blind experimental method may further include a step S110.

Step S110: Delete the grouping information of the plurality of experimental subjects stored in the double-blind experimental device.

Thus, after the group of the target subject is acquired, the group information is deleted, further avoiding the risk of the group information being leaked due to the long storage time of the group information.

In a specific application scenario, when the group of the target experimental subject has been obtained according to the group information, the group information is deleted immediately, which prevents the risk of group information leakage caused by long-term storage of the group information.

Referring to FIG. 6 , in some possible manners, the double-blind experimental method may further include steps S111-S112.

Step S111: using the experimental equipment to receive an unblinding operation on the target subject, where the unblinding operation is normal unblinding or emergency unblinding.

Wherein, the way for the experimental equipment to receive the unblinding operation may be to set a physical unblinding operation button on the experimental equipment, and receive the unblinding operation in response to the physical unblinding operation button being touched; or, set the unblinding operation button on the display screen of the experimental equipment. A blinding operation option, in response to the unblinding operation option being clicked, an unblinding operation is received.

Step S112: Responding to the unblinding operation, using the experimental equipment to display the groups of the target experimental subjects.

Thus, after receiving the unblinding operation, the experimental device is used to display the group of the target experiment subject, so that the group of the target experiment subject can be displayed at an appropriate time.

In a specific application scenario, a desktop computer is used as the experimental equipment. After the experiment is completed, the experimenter operates the desktop computer and clicks the unblinding operation option on the desktop computer. The group is the control group.

Referring to FIG. 7 and FIG. 8 , in some possible manners, the unblinding operation may be normal unblinding, and the step S112 may include steps S301-S303.

Step S301: Obtain experimental status information, which is used to indicate whether the double-blind experiment has been completed.

Step S302: When the experiment status information indicates that the double-blind experiment is not completed, use the experiment device to display an unblinding confirmation page.

Step S303: When the experimental device receives the unblinding determination operation, use the experimental device to display the group of the target experimental subject.

The double-blind experimental method may also include step S113.

Step S113: When the experimental device receives the rejection of the unblinding operation, generate first rejection information and send the first rejection information to the experimental device, so that the experimental device displays the first rejection information.

Therefore, when a normal unblinding request is requested, it is judged whether the double-blind experiment has been completed. When the double-blind experiment is not completed, the experimental equipment is used to display the unblinding confirmation page. During the unblinding operation, the first rejection information is generated and sent to the experimental equipment, thereby preventing normal unblinding when the experiment is not completed due to misoperation.

In a specific application scenario, when the experiment is not completed, the experimenter clicks the unblinding operation option to request normal unblinding. At this time, according to the experimental status information, it is judged that the double-blind experiment has not been completed, and the experimental equipment of the experimenter displays the unblinding confirmation page. The unblinding confirmation page includes an option to determine whether to unblind. The experimenter finds that the experiment has not been completed and can choose not to unblind. At this time, the first rejection message is generated and sent to the experimental equipment and stored in the storage. equipment for easy recording and query.

Referring to FIG. 9 and FIG. 10 , in some possible manners, the unblinding operation may be emergency unblinding, and the step S112 may include steps S401-S402.

Step S401: Obtain the identity and authority information of the experimenter corresponding to the experimental equipment, the identity and authority information is used to indicate whether the experimenter has emergency unblinding authority.

Step S402: When the identity authority information indicates that the experimenter has emergency unblinding authority, use the experiment equipment to display the group of the target experiment subject.

The double-blind experimental method may also include step S114.

Step S114: When the identity authority information indicates that the experimenter does not have emergency unblinding authority, generate second rejection information and send the second rejection information to the experimental equipment, so that the experimental equipment displays the Describe the second rejection message.

Therefore, when requesting emergency unblinding, verify whether the experimenter corresponding to the experimental equipment has the emergency unblinding authority, and if he has the emergency unblinding authority, perform the unblinding, and if he does not have the emergency unblinding authority, generate a second rejection message and send it to To the experimental equipment; thus, the verification of the emergency unblinding authority can ensure that the experimenters who have the emergency unblinding authority can perform emergency unblinding, and at the same time prevent the emergency unblinding when the personnel do not have the emergency unblinding authority. .

In a specific application scenario, the experimenter operates the experimental equipment for emergency unblinding, and obtains the identity and authority information of the experimenter. The identity authority information indicates that the experimenter does not have the emergency unblinding authority. At this time, the unblinding is not performed, and the first 2. Rejection information and send the second rejection information to the experimental equipment, and store it in the storage device, so as to facilitate recording and query.

Referring to Fig. 11, the embodiment of the present application also provides a double-blind experimental device, its specific implementation mode is consistent with that described in the above-mentioned embodiment of the double-blind experimental method, and the technical effect achieved is consistent, and part of the content will not be repeated.

The double-blind experimental device includes: an information acquisition module 101, configured to acquire grouping information of a plurality of experimental subjects, and the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group Execution receiving module 102, configured to use experimental equipment to receive an execution operation on a target experimental subject, where the target experimental subject is one of the plurality of experimental subjects, and the execution operation is used to indicate the identity and parameter of the execution parameter Value; group acquisition module 103, used to respond to the execution operation, based on the grouping information of the plurality of experimental subjects, to acquire the group of the target experimental subject; real execution module 104, used for when the target experiment When the group of objects is the first group, the control actuator executes the first action on the target subject based on the execution operation; the simulation execution module 105 is configured to perform when the group of the target subject is the first action In the second group, do not perform any action on the target test subject, or control the actuator to perform a second action on the target test subject; wherein, the first action and the second action cannot be controlled by the target test subject. Identify the target subjects.

Referring to Fig. 12, the double-blind experimental device may also include: a real feedback module 106, configured to receive the real feedback information sent by the executive agency as the Target feedback information; a simulation feedback module 107, configured to generate simulation feedback information based on the identifier and parameter value of the execution parameter as the target feedback information when the group of the target subject is the second group; A feedback sending module 108, configured to send the target feedback information to the experimental equipment.

Referring to FIG. 13 , the double-blind experimental device may further include: a feedback display module 109, configured to enable the experimental equipment to display the target feedback information in real time.

14, in some possible ways, the information acquisition module 101 includes: a synchronization operation unit 201, configured to receive a synchronization operation using the experimental equipment; a grouping information unit 202, configured to respond to the synchronization operation, from The grouping information of the multiple experimental subjects is obtained from the storage device and stored in the double-blind experimental device.

Referring to FIG. 15 , in some possible manners, the double-blind experimental device may further include: an information deletion module 110 configured to delete the grouping information of the plurality of experimental subjects stored in the double-blind experimental device.

Referring to FIG. 16 , in some possible manners, the double-blind experimental device may further include: an unblinding receiving module 111, configured to use experimental equipment to receive an unblinding operation on the target experimental subject, and the unblinding operation is Normal unblinding or emergency unblinding; the information display module 112 is configured to respond to the unblinding operation and use the experimental equipment to display the group of the target experimental subjects.

Referring to Fig. 17 and Fig. 18, in some possible modes, the unblinding operation is normal unblinding, and the information display module 112 includes: an experiment status unit 301, configured to obtain experiment status information, the experiment status information is used To indicate whether the double-blind experiment has been completed; the unblinding confirmation unit 302 is used to display the unblinding confirmation page by using the experimental equipment when the experimental status information indicates that the double-blind experiment is not completed; the group display unit 303, configured to use the experimental equipment to display the group of the target experimental subject when the experimental equipment receives the determined unblinding operation; the double-blind experimental device may further include: a first rejection module 113, configured to When the experimental device receives the rejection of the unblinding operation, it generates first rejection information and sends the first rejection information to the experimental device, so that the experimental device displays the first rejection information.

Referring to Fig. 19 and Fig. 20, in some possible manners, the unblinding operation is emergency unblinding, and the information display module 112 includes: a permission acquisition unit 401, configured to acquire the identity of the experimenter corresponding to the experimental equipment Authority information, the identity authority information is used to indicate whether the experimenter has emergency unblinding authority; the emergency unblinding unit 402 is used to use the The experimental equipment displays the group of the target experimental subject; the double-blind experimental device may also include: a second rejection module 114, used for when the identity authority information indicates that the experimenter does not have emergency unblinding authority, generating second rejection information and sending the second rejection information to the experimental equipment, so that the experimental equipment displays the second rejection information.

Referring to FIG. 21 , the embodiment of the present application also provides an electronic device 200, which includes at least one memory 210, at least one processor 220, and a bus 230 connecting different platform systems.

Memory 210 may include readable media in the form of volatile memory, such as random access memory (RAM) 211 and/or cache memory 212 , and may further include read only memory (ROM) 213 .

Wherein, the memory 210 also stores a computer program, and the computer program can be executed by the processor 220, so that the processor 220 executes the steps of the double-blind experimental method in the embodiment of the present application. The recorded implementation modes and achieved technical effects are consistent, and some of the contents will not be repeated.

Memory 210 may also include utility 214 having at least one program module 215 including, but not limited to, an operating system, one or more application programs, other program modules, and program data, examples of each or Implementations of network environments may be included in some combination.

Correspondingly, the processor 220 can execute the above-mentioned computer program, and can execute the utility tool 214 .

Bus 230 may be representative of one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or a local bus using any of a variety of bus structures.

The electronic device 200 can also communicate with one or more external devices 240 such as keyboards, pointing devices, Bluetooth devices, etc., and can also communicate with one or more devices capable of interacting with the electronic device 200, and/or communicate with the electronic device 200 200 is capable of communicating with any device (eg, router, modem, etc.) that communicates with one or more other computing devices. Such communication may occur through input-output interface 250 . Moreover, the electronic device 200 can also communicate with one or more networks (such as a local area network (LAN), a wide area network (WAN) and/or a public network such as the Internet) through the network adapter 260 . The network adapter 260 can communicate with other modules of the electronic device 200 through the bus 230 . It should be appreciated that although not shown, other hardware and/or software modules may be used in conjunction with electronic device 200, including but not limited to: microcode, device drivers, redundant processors, external disk drive arrays, RAID systems, tape drives And data backup storage platform, etc.

Referring to FIG. 22 , the embodiment of the present application also provides a double-blind experiment system 500 , which includes an experiment device 300 , an actuator 400 and an electronic device 200 .

In some possible manners, the experimental equipment may be a program-controlled device, and the actuator is a stimulator set in the body of the target experimental subject; the processor may also be used when the group of the target experimental subject is the first When there is one group, control the actuator to apply electrical stimulation based on the execution operation, and receive the real feedback information sent by the actuator as the target feedback information; and when the group of the target subjects is the second group , controlling the actuator not to apply electrical stimulation.

Therefore, the double-blind experiment was carried out by using the program controller and the stimulator, and the experimenters were blinded during the interactive program-controlled electrical stimulation process.

In a specific application scenario, the experimenters conducted double-blind electrical stimulation experiments on Zhang San and Li Si at the same time. Zhang San was the control group and Li Si was the experimental group. Both Zhang San and Li Si were implanted with stimulators as actuators. , for Zhang San, no electrical stimulation is applied, and the processor generates analog feedback information as the target feedback information. The analog feedback information is used to indicate that "the electric stimulation with a voltage of 0.11mv and a duration of 24s is successfully applied to Zhang San", and for Li Si, Apply electrical stimulation, and the stimulator sends real feedback information to indicate "successfully applied electrical stimulation with a voltage of 0.1mv to Li Si and a duration of 25s"; the processor receives the real feedback information as Li Si's corresponding target feedback information and sends it to the experiment equipment.

In some possible manners, the experimental equipment is a drug dispensing control equipment, and the actuator includes a manipulator and a sensor; The execution operation controls the manipulator to distribute the first type of medicine to the target subject, and receives the real feedback information sent by the sensor as the target feedback information; and when the group of the target subject is the second group, controlling the manipulator to distribute the second type of medicine to the target subject.

Wherein, the sensor is, for example, a camera, a pressure sensor, and the like.

Therefore, the double-blind experiment is carried out by using the drug dispensing control equipment and the executive mechanism, and the experimenters are blinded during the interactive drug dispensing process.

In a specific application scenario, the experimenters conducted a double-blind experiment of weight loss health products on Wang Wu and Zhao Liu at the same time. Wang Wu was the control group and Zhao Liu was the experimental group. Distribute experimental health products, in which the shape, size, color, and taste of the placebo and the experimental health products are the same, so that Wang Wu and Zhao Liu cannot distinguish the placebo from the experimental health products, and the processor generates simulated feedback information as Target feedback information, the simulated feedback information is used to indicate "2 boxes of health products have been successfully distributed to Wang Wu", the sensor generates real feedback information "2 boxes of health products have been distributed to Zhao Liu" as the target feedback information; the processor receives the real feedback information As the target feedback information corresponding to Zhao Liu and sent to the experimental equipment.

In some possible manners, the experimental equipment is electromagnetic wave control equipment, and the actuator includes an electromagnetic wave generating device and an electromagnetic wave detecting device; the processor can also be used to , controlling the electromagnetic wave generating device to transmit electromagnetic waves to the target subject based on the execution operation, receiving the real feedback information sent by the electromagnetic wave detection device as the target feedback information; and when the group of the target subject is the second When grouping, the electromagnetic wave generating device is controlled not to emit electromagnetic waves to the target experiment subject; wherein, when the target experiment subject is a human being, whether the electromagnetic wave is emitted cannot be distinguished by the target experiment subject.

Therefore, the double-blind experiment is carried out by using the electromagnetic wave control equipment and the actuator, and the experimenter is blinded during the interactive electromagnetic wave emission process.

In a specific application scenario, experimenters conduct a double-blind experiment of infrared light on animal A and animal B at the same time, wherein animal A and animal B are animals of the same species; animal A is the control group, and animal B is the experimental group. , the electromagnetic wave generating device does not emit infrared rays to animal A, but emits infrared rays to animal B, and the processor generates analog feedback information as target feedback information for animal A, and the analog feedback information is used to indicate the intensity and time of infrared rays emitted to animal A. The electromagnetic wave detection device detects the intensity and time of the infrared rays emitted to the animal B, and generates real feedback information; the processor receives the real feedback information as the target feedback information of the animal B and sends it to the experimental equipment.

The embodiment of the present application also provides a computer-readable storage medium, which is used to store a computer program. When the computer program is executed, the steps of the double-blind experiment method in the embodiment of the present application are implemented. The specific implementation The method is consistent with the implementation method and the achieved technical effect described in the above-mentioned double-blind experimental method, and part of the content will not be repeated.

Fig. 23 shows the program product 600 for realizing the above-mentioned double-blind experiment method provided by this embodiment, it can adopt portable compact disc read-only memory (CD-ROM) and include program code, and can be in terminal equipment, such as personal run on the computer. However, the program product 600 of the present application is not limited thereto. In the present application, the readable storage medium may be any tangible medium containing or storing a program, and the program may be used by or in combination with an instruction execution system, device or device. Program product 600 may utilize any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. The readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or device, or any combination thereof. More specific examples (non-exhaustive list) of readable storage media include: electrical connection with one or more conductors, portable disk, hard disk, random access memory (RAM), read only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), optical storage devices, magnetic storage devices, or any suitable combination of the foregoing.

A computer readable storage medium may include a data signal carrying readable program code in baseband or as part of a carrier wave traveling as part of a data signal. Such propagated data signals may take many forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the foregoing. A readable storage medium may also be any readable medium that can transmit, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. The program code contained on the readable storage medium can be transmitted by any appropriate medium, including but not limited to wireless, cable, optical cable, RF, etc., or any suitable combination of the above. The program code for performing the operation of the present application can be written in any combination of one or more programming languages, and the programming language includes object-oriented programming languages such as Java, C++, etc., and can also include conventional procedural programming A language such as C or a similar programming language. The program code may execute entirely on the user's computing device, partly on the user's device, as a stand-alone software package, partly on the user's computing device and partly on a remote computing device, or entirely on the remote computing device or server to execute. In cases involving a remote computing device, the remote computing device may be connected to the user computing device through any kind of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computing device (e.g., using an Internet service provider). business to connect via the Internet).

This application is elaborated from the perspectives of purpose of use, performance, progress and novelty. The above description and accompanying drawings of this application are only preferred embodiments of this application, and are not intended to limit this application. Therefore, all All structures, devices, features, etc. that are similar or identical to those of the present application, that is, all equivalent replacements or modifications made according to the scope of the patent application of the present application, shall fall within the scope of protection of the patent application of the present application.

Claims

A kind of double-blind experiment device, described double-blind experiment device comprises:

An information acquisition module, configured to acquire grouping information of a plurality of experimental subjects, where the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group;

An execution receiving module, configured to use experimental equipment to receive an execution operation on a target experimental object, the target experimental object is one of the plurality of experimental objects, and the execution operation is used to indicate the identity and parameter value of the execution parameter;

a group acquisition module, configured to acquire the group of the target experimental subject based on the grouping information of the plurality of experimental subjects in response to the execution operation;

A real execution module, configured to control the actuator to perform a first action on the target experiment subject based on the execution operation when the group of the target experiment subject is the first group;

A simulation execution module, configured to not perform any action on the target test subject when the group of the target test subject is the second group, or control the actuator to perform a second action on the target test subject ;

Wherein, the first action and the second action cannot be distinguished by the target subject.
The device according to claim 1, wherein the double-blind experimental device further comprises:

A real feedback module, configured to receive real feedback information sent by an actuator as the target feedback information when the group of the target subject is the first group;

A simulated feedback module, configured to generate simulated feedback information as the target feedback information based on the identifier and parameter value of the execution parameter when the group of the target subject is the second group;

A feedback sending module, configured to send the target feedback information to the experimental equipment.
The device according to claim 2, wherein said double-blind experimental device further comprises:

A feedback display module, configured to enable the experimental equipment to display the target feedback information in real time.
The device according to claim 1, wherein the information acquisition module comprises:

a synchronous operation unit, configured to receive a synchronous operation with the experimental equipment;

A grouping information unit, configured to, in response to the synchronization operation, obtain grouping information of the plurality of experimental subjects from a storage device and store them in the double-blind experimental device.
The device according to claim 4, wherein the double-blind experimental device further comprises:

An information deletion module, configured to delete the grouping information of the plurality of experimental subjects stored in the double-blind experimental device.
The device according to claim 1, wherein the double-blind experimental device further comprises:

An unblinding receiving module, configured to use experimental equipment to receive an unblinding operation on the target subject, where the unblinding operation is normal unblinding or emergency unblinding;

An information display module, configured to use the experimental device to display the group of the target experimental subjects in response to the unblinding operation.
The device according to claim 6, wherein the unblinding operation is normal unblinding, and the information display module includes:

An experimental status unit, configured to obtain experimental status information, and the experimental status information is used to indicate whether the double-blind experiment has been completed;

An unblinding confirmation unit, configured to use the experimental equipment to display an unblinding confirmation page when the experimental status information indicates that the double-blind experiment is not completed;

A group display unit, configured to use the experimental equipment to display the group of the target experimental subject when the experimental equipment receives a definite unblinding operation;

The double-blind experimental device also includes:

The first rejection module is configured to generate first rejection information and send the first rejection information to the experimental equipment when the experimental equipment receives a rejection unblinding operation, so that the experimental equipment displays the first rejection information 1. Reject Information.
The device according to claim 6, wherein the unblinding operation is emergency unblinding, and the information display module includes:

an authority acquisition unit, configured to acquire the identity authority information of the experimenter corresponding to the experimental equipment, and the identity authority information is used to indicate whether the experimenter has emergency unblinding authority;

An emergency unblinding unit, configured to use the experimental equipment to display the group of the target experimental subject when the identity authority information indicates that the experimenter has emergency unblinding authority;

The double-blind experimental device also includes:

The second rejection module is configured to generate second rejection information and send the second rejection information to the experimental equipment when the identity authority information indicates that the experimenter does not have emergency unblinding authority, so that the The experimental device displays the second rejection information.
An electronic device, the electronic device includes a memory and a processor, the memory stores a computer program, and the processor implements the following steps when executing the computer program:

Acquiring grouping information of multiple experimental subjects, where the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group;

Using the experimental device to receive an execution operation on a target experimental subject, the target experimental subject being one of the plurality of experimental subjects, the execution operation being used to indicate the identity and parameter value of the execution parameter;

Responsive to the execution operation, based on the grouping information of the plurality of test subjects, acquire the group of the target test subjects;

When the group of the target test subject is the first group, the control actuator executes a first action on the target test subject based on the execution operation;

When the group of the target test subject is the second group, not performing any action on the target test subject, or controlling the actuator to perform a second action on the target test subject;

Wherein, the first action and the second action cannot be distinguished by the target subject.
A double-blind experimental system, the double-blind experimental system comprising experimental equipment, an executive mechanism and the electronic device according to claim 9.
The system according to claim 10, wherein the experimental equipment is a program-controlled equipment, and the actuator is a stimulator arranged in the target experimental subject;

The processor is further configured to control the executive mechanism to apply electrical stimulation based on the execution operation when the group of the target subject is the first group, and receive real feedback information sent by the actuator as target feedback. information; and when the group of the target subject is the second group, controlling the executive mechanism not to apply electrical stimulation.
The system according to claim 10, wherein the experimental device is a drug distribution control device, and the actuator includes a manipulator and a sensor;

The processor is also used to control the manipulator to distribute the first type of medicine to the target subject based on the execution operation when the group of the target subject is the first group, and receive the real feedback sent by the sensor information as target feedback information; and when the group of the target test subject is the second group, control the manipulator to distribute the second type of medicine to the target test subject.
The system according to claim 10, wherein the experimental equipment is electromagnetic wave control equipment, and the actuator includes an electromagnetic wave generating device and an electromagnetic wave detecting device;

The processor is further configured to control the electromagnetic wave generation device to emit electromagnetic waves to the target experiment subject based on the execution operation when the group of the target experiment subject is the first group, and receive the real data sent by the electromagnetic wave detection device. Feedback information as target feedback information; and when the group of the target test subject is the second group, control the electromagnetic wave generating device not to emit electromagnetic waves to the target test subject; wherein, when the target test subject is a human When , whether the electromagnetic wave is emitted or not cannot be distinguished by the target experiment subject.
A computer-readable storage medium, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the following steps are implemented:

Acquiring grouping information of a plurality of experimental subjects, where the grouping information of the experimental subjects is used to indicate that the group of the experimental subjects is the first group or the second group;

Using the experimental device to receive an execution operation on a target experimental subject, the target experimental subject being one of the plurality of experimental subjects, the execution operation being used to indicate the identifier and parameter value of the execution parameter;

Responding to the performing operation, based on the grouping information of the plurality of test subjects, the group of the target test subjects is acquired;

When the group of the target test subject is the first group, the control actuator executes a first action on the target test subject based on the execution operation;

When the group of the target test subject is the second group, not performing any action on the target test subject, or controlling the actuator to perform a second action on the target test subject;

Wherein, the first action and the second action cannot be distinguished by the target subject.