WO2022255962A1 - A system and method for optimizing nerve stimulation parameters based on changes in the voice of a patient - Google Patents

A system and method for optimizing nerve stimulation parameters based on changes in the voice of a patient Download PDF

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Publication number
WO2022255962A1
WO2022255962A1 PCT/TR2021/050858 TR2021050858W WO2022255962A1 WO 2022255962 A1 WO2022255962 A1 WO 2022255962A1 TR 2021050858 W TR2021050858 W TR 2021050858W WO 2022255962 A1 WO2022255962 A1 WO 2022255962A1
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WO
WIPO (PCT)
Prior art keywords
patient
voice
stimulation
control unit
main control
Prior art date
Application number
PCT/TR2021/050858
Other languages
French (fr)
Inventor
Ali Veysel OZDEN
Ali Can ERK
Original Assignee
Vagustim Saglik Teknolojileri Anonim Sirketi
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Publication date
Priority claimed from TR2021/008961 external-priority patent/TR2021008961A1/en
Application filed by Vagustim Saglik Teknolojileri Anonim Sirketi filed Critical Vagustim Saglik Teknolojileri Anonim Sirketi
Publication of WO2022255962A1 publication Critical patent/WO2022255962A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02405—Determining heart rate variability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4803—Speech analysis specially adapted for diagnostic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • G—PHYSICS
    • G10—MUSICAL INSTRUMENTS; ACOUSTICS
    • G10L—SPEECH ANALYSIS OR SYNTHESIS; SPEECH RECOGNITION; SPEECH OR VOICE PROCESSING; SPEECH OR AUDIO CODING OR DECODING
    • G10L25/00—Speech or voice analysis techniques not restricted to a single one of groups G10L15/00 - G10L21/00
    • G10L25/48—Speech or voice analysis techniques not restricted to a single one of groups G10L15/00 - G10L21/00 specially adapted for particular use
    • G10L25/51—Speech or voice analysis techniques not restricted to a single one of groups G10L15/00 - G10L21/00 specially adapted for particular use for comparison or discrimination
    • G10L25/66—Speech or voice analysis techniques not restricted to a single one of groups G10L15/00 - G10L21/00 specially adapted for particular use for comparison or discrimination for extracting parameters related to health condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0204—Acoustic sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment

Definitions

  • the present invention relates to a system and method for optimizing the electrical signals administered to the nerves of a patient for treating diseases and/or illnesses based on the changes occurring in the voice of a patient.
  • the entirety of the vital functions of the human body is controlled by a system called the autonomic nervous system.
  • all functions of organs that cannot be controlled voluntarily are regulated by the autonomic nervous system.
  • the activities of the autonomic nervous system vary, thereby getting involved in adjusting the human body to the changes occurring in indoor and outdoor environments.
  • Disruptions observed in the varying activities of the autonomic nervous system cause an impairment in the adaptability of the human body to variables of the internal and external environment, thereby resulting in autonomic dysfunction and illnesses associated therewith. Nerve activation through stimulation is utilized as the treatment of observed illnesses and diseases.
  • Nerves may be stimulated by conveying electrical signals to several different nerves from various sections. Different nerves may be stimulated from different parts thereof by sending a signal with different electrical characteristics for the treatment of various illnesses. In contrast therewith, the effects produced by electrical signals administered for the identical treatment also vary depending on different patients. To put it differently, each signal, despite having the same parameters, does not produce the same effect on every patient. Therefore, performing the stimulation process through electrical signals that are both suitable and personalized for a patient in order to achieve a more effective treatment improves the efficiency of the treatment.
  • the inventive method and system allow for recording the voice of a patient prior to the administration of the respective treatment, comparing it to the voice recording of the patient after the nerves thereof are stimulated, and for optimizing the stimulation parameters based on changes between two voice recordings, thereby offering more effective treatment.
  • the object of the present invention is to develop a system and method wherein the electrical signal parameters to be used for stimulating nerves for therapeutic purposes are optimized according to the patient.
  • Another object of the present invention is to develop a system and method wherein the electrical signal parameters used for stimulation are optimized based on the voice changes of the patient.
  • Yet another object of the present invention is to develop a system and method, wherein the electrical signal parameters used for stimulation are optimized in line with the differences observed between the patient's voice recording prior to stimulation and the voice recording after stimulation.
  • the present invention relates to a system and method for optimizing the electrical signals administered to the nerves of a patient for treating diseases and/or illnesses based on the changes occurring in the voice of a patient.
  • the present invention particularly relates to a system and method wherein a patient's voice is recorded and subjected to a comparison before and after stimulating the nerves of the patient with electrical signals for the treatment of diseases and/or illnesses, and the stimulation parameters are optimized based on the changes observed between two voice recordings.
  • the inventive system in the most basic form thereof, comprises at least one stimulator for generating the electrical current that will be used for stimulating nerves, at least one electrode that allows for transmitting the electrical current generated by said stimulator to nerves, and at least one voice recording unit that allows for recording the voice of the patient.
  • the parameters of the electrical current to be transferred to the respective nerve by means of an electrode may be adjusted according to the disease desired to be treated and to the patient who will be administered a treatment. Electrical signal parameters that would benefit each patient may differ from one another. Therefore, knowing what electrical signal parameter produces what sort of results in what kind of patient is crucial.
  • the changes induced by the stimulation of nerves in the patient based on the changes occurring in the voice of the patient are determined by taking advantage of the innervation of the structures in the larynx (throat) that are involved in voice production by the nerves, and by the vagus nerve in particular.
  • a patient's voice is recorded by means of at least one voice recording unit in the inventive system before the nerves of the patient are stimulated, the patient's voice is recorded once again subsequent to the stimulation of respective nerves, two voice recordings are compared, thereby gathering information regarding the efficiency of the stimulation based on the changes in the voice of the patient and electrical signal parameters are optimized in order to achieve a more effective stimulation.
  • the voice recording unit that allows for recording the voice of the patient is a smart device, preferably, a smartphone.
  • the voice recording of the patient prior to stimulation and the voice recording of the patient after stimulation are compared in terms of the fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or the phonation index of the voice.
  • voice recordings of the patient both before and after stimulation, as well as the differences between said voice recordings are recorded along with the patient's other subjective and/or objective data.
  • said subjective data is the data gathered from symptom questionnaires.
  • the objective data includes biological data of the patient such as pulse, heart rate variation, blood pressure, etc.
  • said data is stored on a database, preferably, on a database that is open to online access.
  • Another preferred embodiment of the present invention comprises at least one main control unit in which the data received from the voice recording unit are recorded and/or said voice recordings are compared to one another.
  • the parameters of the electrical signal to be transmitted to electrodes by means of the stimulator based on the comparison carried out between the voice recording before stimulation and the voice recording after stimulation in terms of the fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or phonation index of the voice, preferably, the pulse width and/or duration and/or waveform and/or frequency of the signal may either be changed automatically by means of the main control unit or manually by the operator.
  • the connection between the main control unit and the stimulator is a wireless connection. Therefore, the main control unit and the stimulator are capable of communicating wirelessly with one another.
  • the voice recording unit is located on the main control unit.
  • said main control unit is a smart device capable of communicating with the stimulator and comprises at least one microphone.
  • a preferred embodiment of the present invention comprises two or more than two electrodes that allow for transmitting the electrical current to the nerve that will be stimulated.
  • the stimulation process is performed such that it is invasive, semi-invasive, or non-invasive. More specifically, electrodes and/or stimulator are positioned in an invasive, or semi-invasive, or non-invasive manner.
  • the stimulated nerve is the vagus nerve, and the electrode or electrodes are positioned so as to stimulate the vagus nerve.
  • the stimulated nerve is the auricular vagus nerve.
  • the inventive method comprises the process steps of;
  • the patient's voice is recorded for a duration of 3-10 seconds prior to stimulation.
  • the inventive system and method allow for revising the electrical signal parameters used for stimulating the nerves of the patient based on the changes between the voice of the patient before and after stimulation, thereby providing more effective treatment.

Abstract

The present invention relates to a system and method for optimizing the electrical signals administered to the nerves of a patient for treating diseases and/or illnesses based on the changes occurring in the voice of a patient. The present invention particularly relates to a system and method wherein a patient's voice is recorded and subjected to a comparison before and after stimulating the nerves of the patient with electrical signals for the treatment of diseases and/or illnesses, and the stimulation parameters are optimized based on the changes observed between two voice recordings.

Description

A SYSTEM AND METHOD FOR OPTIMIZING NERVE STIMULATION PARAMETERS BASED ON
CHANGES IN THE VOICE OF A PATIENT
Technical Field of the Invention
The present invention relates to a system and method for optimizing the electrical signals administered to the nerves of a patient for treating diseases and/or illnesses based on the changes occurring in the voice of a patient.
State of the Art
The entirety of the vital functions of the human body is controlled by a system called the autonomic nervous system. Worded differently, all functions of organs that cannot be controlled voluntarily are regulated by the autonomic nervous system. In daily life, the activities of the autonomic nervous system vary, thereby getting involved in adjusting the human body to the changes occurring in indoor and outdoor environments. Disruptions observed in the varying activities of the autonomic nervous system cause an impairment in the adaptability of the human body to variables of the internal and external environment, thereby resulting in autonomic dysfunction and illnesses associated therewith. Nerve activation through stimulation is utilized as the treatment of observed illnesses and diseases.
Nerves may be stimulated by conveying electrical signals to several different nerves from various sections. Different nerves may be stimulated from different parts thereof by sending a signal with different electrical characteristics for the treatment of various illnesses. In contrast therewith, the effects produced by electrical signals administered for the identical treatment also vary depending on different patients. To put it differently, each signal, despite having the same parameters, does not produce the same effect on every patient. Therefore, performing the stimulation process through electrical signals that are both suitable and personalized for a patient in order to achieve a more effective treatment improves the efficiency of the treatment.
The inventive method and system allow for recording the voice of a patient prior to the administration of the respective treatment, comparing it to the voice recording of the patient after the nerves thereof are stimulated, and for optimizing the stimulation parameters based on changes between two voice recordings, thereby offering more effective treatment. Objects of the Invention
The object of the present invention is to develop a system and method wherein the electrical signal parameters to be used for stimulating nerves for therapeutic purposes are optimized according to the patient.
Another object of the present invention is to develop a system and method wherein the electrical signal parameters used for stimulation are optimized based on the voice changes of the patient.
Yet another object of the present invention is to develop a system and method, wherein the electrical signal parameters used for stimulation are optimized in line with the differences observed between the patient's voice recording prior to stimulation and the voice recording after stimulation.
Detailed Description of the Invention
The present invention relates to a system and method for optimizing the electrical signals administered to the nerves of a patient for treating diseases and/or illnesses based on the changes occurring in the voice of a patient. The present invention particularly relates to a system and method wherein a patient's voice is recorded and subjected to a comparison before and after stimulating the nerves of the patient with electrical signals for the treatment of diseases and/or illnesses, and the stimulation parameters are optimized based on the changes observed between two voice recordings.
The inventive system, in the most basic form thereof, comprises at least one stimulator for generating the electrical current that will be used for stimulating nerves, at least one electrode that allows for transmitting the electrical current generated by said stimulator to nerves, and at least one voice recording unit that allows for recording the voice of the patient.
The parameters of the electrical current to be transferred to the respective nerve by means of an electrode may be adjusted according to the disease desired to be treated and to the patient who will be administered a treatment. Electrical signal parameters that would benefit each patient may differ from one another. Therefore, knowing what electrical signal parameter produces what sort of results in what kind of patient is crucial. In the inventive system, the changes induced by the stimulation of nerves in the patient based on the changes occurring in the voice of the patient are determined by taking advantage of the innervation of the structures in the larynx (throat) that are involved in voice production by the nerves, and by the vagus nerve in particular. To that end, a patient's voice is recorded by means of at least one voice recording unit in the inventive system before the nerves of the patient are stimulated, the patient's voice is recorded once again subsequent to the stimulation of respective nerves, two voice recordings are compared, thereby gathering information regarding the efficiency of the stimulation based on the changes in the voice of the patient and electrical signal parameters are optimized in order to achieve a more effective stimulation.
In a preferred embodiment of the present invention, the voice recording unit that allows for recording the voice of the patient is a smart device, preferably, a smartphone.
In a preferred embodiment of the present invention, the voice recording of the patient prior to stimulation and the voice recording of the patient after stimulation are compared in terms of the fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or the phonation index of the voice.
In a preferred embodiment of the present invention, voice recordings of the patient both before and after stimulation, as well as the differences between said voice recordings, are recorded along with the patient's other subjective and/or objective data. In a preferred embodiment of the present invention, said subjective data is the data gathered from symptom questionnaires. In another preferred embodiment of the present invention, the objective data includes biological data of the patient such as pulse, heart rate variation, blood pressure, etc. In a preferred embodiment of the present invention, said data is stored on a database, preferably, on a database that is open to online access.
Another preferred embodiment of the present invention comprises at least one main control unit in which the data received from the voice recording unit are recorded and/or said voice recordings are compared to one another.
The parameters of the electrical signal to be transmitted to electrodes by means of the stimulator based on the comparison carried out between the voice recording before stimulation and the voice recording after stimulation in terms of the fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or phonation index of the voice, preferably, the pulse width and/or duration and/or waveform and/or frequency of the signal may either be changed automatically by means of the main control unit or manually by the operator. In a preferred embodiment of the present invention, the connection between the main control unit and the stimulator is a wireless connection. Therefore, the main control unit and the stimulator are capable of communicating wirelessly with one another.
In a preferred embodiment of the present invention, the voice recording unit is located on the main control unit. In another preferred embodiment of the present invention, said main control unit is a smart device capable of communicating with the stimulator and comprises at least one microphone.
A preferred embodiment of the present invention comprises two or more than two electrodes that allow for transmitting the electrical current to the nerve that will be stimulated.
In a preferred embodiment of the present invention, the stimulation process is performed such that it is invasive, semi-invasive, or non-invasive. More specifically, electrodes and/or stimulator are positioned in an invasive, or semi-invasive, or non-invasive manner.
In a preferred embodiment of the present invention, the stimulated nerve is the vagus nerve, and the electrode or electrodes are positioned so as to stimulate the vagus nerve. In a preferred embodiment of the present invention, the stimulated nerve is the auricular vagus nerve.
The inventive method comprises the process steps of;
• recording patient's voice by means of the voice recording unit,
• stimulating patient's nerve,
• recording patient's voice after stimulation,
• comparing the voice recording recorded before stimulation and the voice recording recorded after stimulation and determining the differences therebetween,
• revising electrical signal parameters administered to nerves for stimulation in line with the differences.
In the inventive method, the patient's voice is recorded for a duration of 3-10 seconds prior to stimulation.
The inventive system and method allow for revising the electrical signal parameters used for stimulating the nerves of the patient based on the changes between the voice of the patient before and after stimulation, thereby providing more effective treatment.

Claims

1. A system for treating diseases and/or illnesses by electrically stimulating the nerve of the patient, characterized in that, it comprises; at least one stimulator that generates the electrical current to be used for stimulating the respective nerve of a patient; at least one electrode that allows for transmitting the electrical current generated by the stimulator to the nerve of the patient; and at least one voice recording unit that enables recording the patient's voice for establishing the differences in voice recordings to be used in determining the electrical signal parameters to be transmitted to the patient.
2. A system according to Claim 1, characterized in that, said stimulator allows for adjusting the electrical current parameters to be transmitted to nerves by means of the electrodes.
3. A system according to any one of the preceding claims, characterized in that, said voice recording unit allows for recording the voice of the patient both before and after the stimulation of the nerves of the patient.
4. A system according to any one of the preceding claims, characterized in that, said voice recording unit is a smart device.
5. A system according to Claim 4, characterized in that, said voice recording device is a smartphone.
6. A system according to any one of the preceding claims, characterized in that, it comprises at least one main control unit in which the patient's voice is recorded both before and after stimulation for detecting the changes induced by the stimulation in the patient's voice based on the determination of the changes in patient's voice before and after the stimulation of patient's nerves, and/or in which the changes between voices are detected.
7. A system according to Claim 6, characterized in that, said main control unit is a control unit which records the fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or phonation index of the voice both before and after stimulation.
8. A system according to Claim 6 or Claim 7, characterized in that, said main control unit is a control unit by which voice recordings before and after stimulation are compared in terms of the fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or phonation index.
9. A system according to Claim 6 or Claim 7, characterized in that, said main control unit is a main control unit which records the voice of the patient before and after stimulation along with the patient's other subjective and/or objective data.
10. A system according to Claim 9, characterized in that, said subjective data includes the data obtained from symptom questionnaires.
11. A system according to Claim 9, characterized in that, said objective data is the physiological data that belongs to the patient.
12. A system according to Claim 11, characterized in that, said physiological data includes the patient's pulse and/or heart rate variations and/or blood pressure.
13. A system according to any one of Claims 9-12, characterized in that, said voice recordings and the data are stored on a database that is open to online access.
14. A system according to any one of Claims 9-13, characterized in that, said main control unit allows for changing the electrical signal parameters, which will be transmitted to electrodes by means of the stimulator, based on the changes between the patient's voice before and after stimulation.
15. A system according to Claim 14, characterized in that, said main control unit allows for changing the pulse width and/or duration and/or waveform and/or frequency of the electrical signal, which will be transmitted to electrodes by means of the stimulator, based on the changes in between the voice of the patient before and after stimulation.
16. A system according to Claim 15, characterized in that, said main control unit enables changing the electrical signal parameters automatically according to changes in the patient's voice and/or allows an operator to change the electrical signal parameters manually.
17. A system according to any one of Claims 6-16, characterized in that, said voice recording unit is located on the main control unit.
18. A system according to any one of Claims 6-17, characterized in that, said main control unit is a smart device capable of establishing a connection with the stimulator.
19. A system according to any one of Claims 6-18, characterized in that, said main control unit is capable of wirelessly communicating with the stimulator.
20. A system according to any one of Claims 1-2 or Claims 6-19, characterized in that, said stimulator is capable of wirelessly communicating with the main control unit.
21. A system according to any one of the preceding claims, characterized in that, it comprises two or more than two electrodes that allow for transmitting the electrical current to the nerve to be stimulated.
22. A system according to any one of the preceding claims, characterized in that, said electrodes and/or stimulator are positioned in an invasive or semi-invasive, or non-invasive manner on the patient.
23. A system according to any one of the preceding claims, characterized in that, the nerve that is stimulated is the vagus nerve, and the electrode or electrodes are positioned to stimulate the vagus nerve.
24. A system according to Claim 23, characterized in that, the nerve that is stimulated is the auricular vagus nerve, and the electrode or electrodes are positioned to stimulate the auricular vagus nerve.
25. A system according to any one of Claims 6-18 or 23-24, characterized in that, said main control unit is a main control unit which determines the changes induced by the stimulation of nerves in the patient based on the changes occurring in the voice of the patient by taking advantage of the innervation of the structures in the larynx that are involved in voice production by the nerves, and by the vagus nerve in particular, and optimizes the electrical signal parameters.
26. A method for treating diseases and/or illnesses by electrically stimulating the respective nerve of the patient, characterized in that, it comprises the process steps of;
• recording patient's voice by means of the voice recording unit prior to stimulation,
• stimulating patient's nerve, • recording patient's voice after stimulation,
• comparing the voice recording recorded before stimulation and the voice recording recorded after stimulation and determining the differences therebetween,
• revising electrical signal parameters administered to nerves for stimulation in line with the differences.
27. A method according to Claim 26, characterized in that, voice recordings before and after stimulation are compared in terms of fundamental frequency and/or jitter rate and/or shimmer rate and/or noise harmonic rate and/or phonation index of the voice.
28. A method according to Claim 26 or Claim 27, characterized in that, the voice recording of the patient is recorded by means of at least one voice recording unit.
29. A method according to any one of Claims 26-28, characterized in that, patient's voice recording before the stimulation and the voice recording after the stimulation are compared to one another by means of the main control unit.
30. A method according to Claim 29, characterized in that, patient's voice recordings before and after stimulation are compared to one another in order to determine the changes induced by the stimulation of the nerves of the patient based on the changes in the patient's voice by taking advantage of the innervation of the structures in the larynx that are involved in voice production by the nerves, and by the vagus nerve in particular.
31. A method according to any one of Claims 26-30, characterized in that, the electrical signals are transmitted to electrodes by means of the stimulator in order to stimulate the nerves.
32. A method according to any one of Claims 26-31, characterized in that, the electrical signals transmitted by means of the stimulator for the stimulation of nerves are administered to the nerves by means of electrodes.
33. A method according to Claim 32, characterized in that, the electrical signal transmitted to electrodes by means of the stimulator is administered to the vagus nerve by means of electrodes.
34. A method according to Claim 33, characterized in that, the electrical signal transmitted to electrodes by means of the stimulator is administered to the auricular vagus nerve by means of electrodes.
35. A method according to any one of Claims 26-33, characterized in that, patient's voice recordings both before and after stimulation are recorded along with the patient's subjective and/or objective data.
36. A method according to Claim 35, characterized in that, said subjective data includes the data obtained from symptom questionnaires.
37. A method according to Claim 35, characterized in that, said objective data is the physiological data that belongs to the patient.
38. A method according to Claim 37, characterized in that, said physiological data includes the patient's pulse and/or heart rate variations and/or blood pressure.
39. A method according to any one of Claims 35-38, characterized in that, said data is stored on a database.
40. A method according to Claim 39, characterized in that, said data is stored on a database that is open to online access.
41. A method according to Claim 31, characterized in that, the pulse width and/or duration and/or waveform and/or frequency of the electrical signals transmitted to electrodes for being administered to patient's nerves are revised according to the changes observed in voice recordings before and after stimulation.
42. A method according to Claim 41, characterized in that, electrical signal parameters transmitted to electrodes for being administered to the patient's nerves are revised automatically by the main control unit and/or manually by an operator based on the changes observed in voice recordings before and after stimulation.
43. A method according to any one of Claims 29-31, characterized in that, said main control unit is wirelessly connected to the stimulator.
44. A method according to any one of Claims 26-43, characterized in that, the patient's voice is recorded for a duration of 3-10 seconds before the stimulation.
PCT/TR2021/050858 2021-05-31 2021-08-25 A system and method for optimizing nerve stimulation parameters based on changes in the voice of a patient WO2022255962A1 (en)

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WO2018071630A1 (en) * 2016-10-12 2018-04-19 Elwha Llc Multi-factor control of ear stimulation
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US20190351230A1 (en) * 2014-06-13 2019-11-21 Neuvana, Llc Transcutaneous electrostimulator and methods for electric stimulation
WO2018071630A1 (en) * 2016-10-12 2018-04-19 Elwha Llc Multi-factor control of ear stimulation
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