WO2022228806A1 - Biphasic cosmetic composition and application thereof - Google Patents
Biphasic cosmetic composition and application thereof Download PDFInfo
- Publication number
- WO2022228806A1 WO2022228806A1 PCT/EP2022/058147 EP2022058147W WO2022228806A1 WO 2022228806 A1 WO2022228806 A1 WO 2022228806A1 EP 2022058147 W EP2022058147 W EP 2022058147W WO 2022228806 A1 WO2022228806 A1 WO 2022228806A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cosmetic composition
- sulfate
- sodium
- laureth
- ppg
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 163
- 239000002537 cosmetic Substances 0.000 title claims abstract description 117
- 230000002051 biphasic effect Effects 0.000 title claims abstract description 115
- 239000012071 phase Substances 0.000 claims abstract description 51
- 239000004480 active ingredient Substances 0.000 claims abstract description 30
- 239000008346 aqueous phase Substances 0.000 claims abstract description 22
- 239000000839 emulsion Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims abstract description 5
- 238000012384 transportation and delivery Methods 0.000 claims abstract description 5
- -1 oxypropylene group Chemical group 0.000 claims description 100
- 150000002191 fatty alcohols Chemical class 0.000 claims description 70
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 59
- 229920006395 saturated elastomer Polymers 0.000 claims description 46
- 239000003921 oil Substances 0.000 claims description 40
- 235000019198 oils Nutrition 0.000 claims description 39
- 239000000306 component Substances 0.000 claims description 36
- 239000003945 anionic surfactant Substances 0.000 claims description 34
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 30
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 claims description 26
- 239000011734 sodium Substances 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 25
- 229910052708 sodium Inorganic materials 0.000 claims description 24
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 21
- 239000000194 fatty acid Substances 0.000 claims description 21
- 229930195729 fatty acid Natural products 0.000 claims description 21
- 150000002170 ethers Chemical class 0.000 claims description 20
- 229940083542 sodium Drugs 0.000 claims description 16
- 239000004094 surface-active agent Substances 0.000 claims description 16
- 239000002280 amphoteric surfactant Substances 0.000 claims description 15
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical class CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 15
- 150000004665 fatty acids Chemical class 0.000 claims description 15
- 150000002430 hydrocarbons Chemical class 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 14
- 229910052700 potassium Inorganic materials 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 13
- 125000006353 oxyethylene group Chemical group 0.000 claims description 13
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 12
- 229940073669 ceteareth 20 Drugs 0.000 claims description 12
- 229940073642 ceteareth-30 Drugs 0.000 claims description 12
- GTABBGRXERZUAH-UHFFFAOYSA-N hexadecan-1-ol;2-methyloxirane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCCCCCCO GTABBGRXERZUAH-UHFFFAOYSA-N 0.000 claims description 12
- 239000011591 potassium Substances 0.000 claims description 12
- 229920002545 silicone oil Polymers 0.000 claims description 11
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 10
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 10
- 229930195733 hydrocarbon Natural products 0.000 claims description 10
- 229940080728 steareth-30 Drugs 0.000 claims description 9
- XMVBHZBLHNOQON-UHFFFAOYSA-N 2-butyl-1-octanol Chemical compound CCCCCCC(CO)CCCC XMVBHZBLHNOQON-UHFFFAOYSA-N 0.000 claims description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 8
- 150000001298 alcohols Chemical class 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 6
- 229940056318 ceteth-20 Drugs 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 229940100459 steareth-20 Drugs 0.000 claims description 6
- 229940024606 amino acid Drugs 0.000 claims description 5
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 5
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 4
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 claims description 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 4
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 claims description 4
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 4
- 239000004215 Carbon black (E152) Chemical class 0.000 claims description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 4
- 229940112261 ceteareth-2 Drugs 0.000 claims description 4
- 229960000541 cetyl alcohol Drugs 0.000 claims description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 4
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 4
- 229940079886 disodium lauryl sulfosuccinate Drugs 0.000 claims description 4
- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 claims description 4
- 239000008240 homogeneous mixture Substances 0.000 claims description 4
- BOUCRWJEKAGKKG-UHFFFAOYSA-N n-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide Chemical compound CCN(CC)CC1=CC(NC(C)=O)=CC=C1O BOUCRWJEKAGKKG-UHFFFAOYSA-N 0.000 claims description 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 4
- 229940055577 oleyl alcohol Drugs 0.000 claims description 4
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 229940012831 stearyl alcohol Drugs 0.000 claims description 4
- AZLWQVJVINEILY-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCOCCOCCO AZLWQVJVINEILY-UHFFFAOYSA-N 0.000 claims description 3
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 3
- 239000010775 animal oil Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 3
- 229940081620 ceteth-2 Drugs 0.000 claims description 3
- 125000005456 glyceride group Chemical group 0.000 claims description 3
- 229940031726 laureth-10 Drugs 0.000 claims description 3
- 229940100491 laureth-2 Drugs 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
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- QNYWMNCOJRYQJB-UHFFFAOYSA-N 2-methyloxirane;1-octadecoxyoctadecane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC QNYWMNCOJRYQJB-UHFFFAOYSA-N 0.000 claims description 2
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 2
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 2
- FMBMJZOGMAKBLM-UHFFFAOYSA-N azane;sulfo dodecanoate Chemical compound [NH4+].CCCCCCCCCCCC(=O)OS([O-])(=O)=O FMBMJZOGMAKBLM-UHFFFAOYSA-N 0.000 claims description 2
- MKHVZQXYWACUQC-UHFFFAOYSA-N bis(2-hydroxyethyl)azanium;dodecyl sulfate Chemical compound OCCNCCO.CCCCCCCCCCCCOS(O)(=O)=O MKHVZQXYWACUQC-UHFFFAOYSA-N 0.000 claims description 2
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- ZPRZNBBBOYYGJI-UHFFFAOYSA-L disodium;2-[1-[2-(carboxylatomethoxy)ethyl]-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCOCC([O-])=O)CC([O-])=O ZPRZNBBBOYYGJI-UHFFFAOYSA-L 0.000 claims description 2
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 229940094506 lauryl betaine Drugs 0.000 claims description 2
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- KKXWPVVBVWBKBL-UHFFFAOYSA-N n,n-diethylethanamine;dodecyl hydrogen sulfate Chemical compound CC[NH+](CC)CC.CCCCCCCCCCCCOS([O-])(=O)=O KKXWPVVBVWBKBL-UHFFFAOYSA-N 0.000 claims description 2
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 claims description 2
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- 239000011718 vitamin C Substances 0.000 description 1
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- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
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- 239000011712 vitamin K Substances 0.000 description 1
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Classifications
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- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
Definitions
- the present invention relates to a biphasic cosmetic composition, wherein two separate phases are present as an emulsion phase and a clear aqueous phase.
- the present invention also re lates to a process for applying the biphasic cosmetic composition comprising cosmetically active ingredients, and to the use of the biphasic cosmetic composition as a delivery system for cos metically active ingredients.
- biphasic cosmetic compositions that is to say comprising two immisci ble phases which are distinct from one another at rest, and which are capable of forming a mac- roscopically homogeneous mixture when the composition is shook, one of the phases then be ing dispersed in the other phase, generally in the form of fine droplets or microdroplets.
- these compositions comprise an aqueous phase and an oily phase as two separate phases.
- a biphasic cosmetic composition that can simultaneously de liver aqueous-based and oil-based ingredients to skin with a very soft and fresh sensory, which can provide not only cleansing effect but also moisturizing and smoothing skin care effect.
- the composition additionally has a unique and appealing appear ance to attract the consumer’s attention.
- Such a composition should deliver the components of each phase in a way that retains the benefits of each with reduced amounts of oily components.
- Such a cosmetic composition that contains reduced amounts of surfactant that might have unintended deleterious effects on the skin and bioaccumulation prob lems.
- One object of the present invention lies in providing a biphasic cosmetic composition, wherein two separate phases are present as an emulsion phase and a clear aqueous phase.
- two phases are mixed to form a temporary uniform emulsion, then applied to skin with a very soft and fresh sensory.
- the clear-cut separation surface of two phases will recover after a settling time period within 8 hours, preferably within 6 hours.
- the object of the present invention can be achieved by a biphasic cosmetic composition com prising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group con sisting of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, and preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition.
- a biphasic cosmetic composition comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or un saturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consist ing of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, and at least one oil component, wherein the oil component comprises hydrocarbons and hydro carbon derivatives, glycerides, ethers, esters, carbonates, fatty alcohols, fatty acids, fatty acid esters, fatty alcohol ethers, vegetable oils, animal oils, silicone oils, mineral oils (paraffin oils) and combinations thereof, and preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composi
- a biphasic cosmetic composition comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or un saturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consist ing of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, and at least one fatty alcohol having from 6 to 22 carbon atoms, and preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition.
- a biphasic cosmetic composition comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or un saturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consist ing of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, and fatty alcohol having from 6 to 22 carbon atoms, and preferably the fatty alcohol polyoxy alkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition, and the weight ratio of the fatty alcohol polyoxyalkylene ethers to fatty alcohols is 1 : 10 to 10:1.
- a biphasic cosmetic composition comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or un saturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consisting of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, and at least one surfactant selected from a group consisting of anionic surfactant and amphoter ic surfactant, and preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition, and the anionic surfactant or amphoteric surfactant is present in an amount of from 0.001 to 5 wt%, based on the total weight of the biphasic cosmetic composition.
- a biphasic cosmetic composition comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or un saturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consist- ing of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, fatty alcohol having from 6 to 22 carbon atoms, and at least one surfactant selected from a group consisting of anionic surfactant and amphoteric surfactant, and preferably the fatty alco hol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition, the weight ratio of the fatty alcohol polyoxy alkylene ethers to fatty alcohols is 1:10 to 10:1, and the anionic surfactant or
- the present invention provides a biphasic cosmetic composition, comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’)nH, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or un saturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consist ing of oxyethylene group and oxypropylene group and combination thereof, and n is 2 to 30, wherein two separate phases are present as an emulsion phase and a clear aqueous phase, and preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition.
- the biphasic cosmetic composition according to the present invention comprises fatty alcohol polyoxyalkylene ether and fatty alcohol having from 6 to 22 carbon at oms, wherein preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition, and the weight ratio of the fatty alcohol polyoxyalkylene ethers to fatty alcohols is 1:10 to 10:1.
- the biphasic cosmetic composition according to the present invention comprises fatty alcohol polyoxyalkylene ether and at least one surfactant selected from a group consisting of anionic surfactant and amphoteric surfactant, wherein preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition, and the anionic surfactant or amphoteric surfac tant is present in an amount of from 0.001 to 5 wt%, based on the total weight of the biphasic cosmetic composition.
- the biphasic cosmetic composition according to the present invention comprises fatty alcohol polyoxyalkylene ether, fatty alcohol having from 6 to 22 carbon atoms, and at least one surfactant selected from a group consisting of anionic surfactant and amphoteric surfactant, wherein preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic compo sition, the weight ratio of the fatty alcohol polyoxyalkylene ethers to fatty alcohols is 1:10 to 10:1, and the anionic surfactant or amphoteric surfactant is present in an amount of from 0.001 to 5 wt%, based on the total weight of the biphasic cosmetic composition.
- the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic compo sition
- the present invention provides a process for preparing the biphasic cosmet ic composition according to the invention, comprising mixing the components of the biphasic cosmetic composition.
- the present invention provides the biphasic cosmetic composition comprising cosmetically active ingredients which are stably present in the composition.
- the present invention provides the use of the biphasic cosmetic composition according to the invention as a delivery system for cosmetically active ingredients.
- the present invention provides a process for applying the biphasic cosmetic composition comprising cosmetically active ingredients according to the invention, comprising shaking the composition to form a macroscopically homogeneous mixture and applying the mix ture to skin.
- the biphasic cosmetic composition according to the present invention comprises two separate phases as an emulsion phase and a substantially clear or clear aque ous phase, wherein the emulsion phase floats above the aqueous phase at rest and a clear-cut separation surface of two phases is formed.
- the biphasic cosmetic composition according to the present invention is shook, two phases are mixed to form a temporary uniform emulsion, and the clear-cut separation surface of two phases will recover after a settling time period within 8 hours, preferably within 6 hours.
- the biphasic cosmetic composition according to the present invention can simultaneously deliver aqueous-based and oil-based ingredients to skin with a very soft and fresh sensory.
- the biphasic cosmetic composition according to the present inven tion can deliver the components of each phase in a way that retains the benefits of each with reduced amounts of oily components.
- the biphasic cosmetic composition according to the pre sent invention contains reduced amounts of surfactant that might have unintended deleterious effects on the skin and bioaccumulation problems.
- Figure 1 shows a photo of the biphasic cosmetic composition of the inventive Example 1 at rest, comprising an emulsion phase and a clear aqueous phase, wherein the emulsion phase floats above the clear aqueous phase at rest and a clear-cut separation surface of two phases is formed.
- Figure 2 shows a photo of the composition of the comparative Example 1 at rest, wherein the water-oil phase separation occurs, and floccule appears at the aqueous phase.
- Figure 3 shows a photo of the composition of the comparative Example 2 at rest, wherein water and oil separate without forming a biphasic cosmetic composition comprising an emulsion phase and a clear aqueous phase.
- the present invention provides a biphasic cosmetic composition, comprising fatty alcohol polyoxyalkylene ether of the formula R-0-(R’) n H, wherein R is saturated or unsatu rated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain, R’ is selected from a group consisting of oxy- ethylene group and oxypropylene group and combination thereof, preferably oxyethylene group, and n is 2 to 30, wherein two separate phases are present as an emulsion phase and a clear aqueous phase, and preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic composition.
- R is saturated or unsatu rated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain
- the fatty alcohol polyoxyalkylene ether is of the formula R-0-(R’) n H, wherein R is saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain or a mixture of saturated or unsaturated, linear or branched Cs to C22 hydrocarbon chain, preferably saturated or unsaturated, linear or branched C10 to C20 hydrocarbon chain or a mix ture of saturated or unsaturated, linear or branched C10 to C20 hydrocarbon chain, more prefera bly saturated or unsaturated, linear or branched C12 to Cis hydrocarbon chain or a mixture of saturated or unsaturated, linear or branched C12 to Cis hydrocarbon chain, R’ is selected from a group consisting of oxyethylene group and oxypropylene group and combination thereof, pref erably oxyethylene group, and n is 2 to 30, preferably 10 to 30, more preferably 15 to 30.
- Nonlimiting examples of the fatty alcohol polyoxyalkylene ethers include the fatty alcohol poly oxyethylene ethers, which are selected from a group consisting of the ceteareth series such as ceteareth-2 to ceteareth-30, preferably ceteareth-10, ceteareth-20 or ceteareth-30, more prefer ably ceteareth-20 or ceteareth-30; the ceteth series, such as ceteth-2 to ceteth-30, preferably ceteth-10, ceteth-20 or ceteth-30, more preferably ceteth-20 or ceteth-30; the steareth series, steareth-2 to steareth-30, preferably steareth- 10, steareth-20 or steareth-30, more preferably steareth-20 or steareth-30; and the laureth series such as laureth-2 to laureth-30, preferably laureth-10, laureth-20 or laureth-30, more preferably laureth-20 or laureth-30; the fatty alcohol polyoxypropylene
- the fatty alcohol polyoxyalkylene ethers include the fatty alcohol polyoxyethylene ethers, which are selected from a group consisting of the ceteareth series such as ceteareth-2 to ceteareth-30, preferably ceteareth-10, ceteareth-20 or ceteareth-30, more preferably ceteareth-20 or ceteareth-30; the ceteth series, such as ceteth-2 to ceteth-30, prefer ably ceteth-10, ceteth-20 or ceteth-30, more preferably ceteth-20 or ceteth-30; the steareth se ries, steareth-2 to steareth-30, preferably steareth-10, steareth-20 or steareth-30, more prefera bly steareth-20 or steareth-30; and the laureth series such as laureth-2 to laureth-30, preferably laureth-10, laureth-20 or laureth-30, more preferably laureth-20 or laureth-30.
- the ceteareth series such
- the fatty alcohol polyoxyalkylene ethers include the fatty alco hol polyoxyethylene ethers, which are selected from a group consisting of the ceteareth series such as ceteareth-2 to ceteareth-30, preferably ceteareth- 10, ceteareth-20 or ceteareth-30, more preferably ceteareth-20 or ceteareth-30 (for example Eumulgin ® B2 (commercially availa ble from BASF), and Eumulgin ® B3 (commercially available from BASF)).
- ceteareth series such as ceteareth-2 to ceteareth-30, preferably ceteareth- 10, ceteareth-20 or ceteareth-30, more preferably ceteareth-20 or ceteareth-30
- Eumulgin ® B2 commercially availa ble from BASF
- Eumulgin ® B3 commercially available from BASF
- the fatty alcohol polyoxyalkylene ethers may be present in an amount of from 0.001 to 1.0 wt%, for example 0.005 to 0.2 wt%, preferably from 0.01 to 0.15 wt%, more preferably from 0.03 to 0.1 wt%, based on the total weight of the biphasic cosmetic composition.
- the biphasic cosmetic compositions according to the invention comprise oil components in the emulsion phase.
- the oil components may comprise hydrocarbons and hydrocarbon derivatives, glycerides, ethers, esters, carbonates, fatty alcohols, fatty acids, fatty acid esters, fatty alcohol ethers, vegetable oils, animal oils, silicone oils, mineral oils (paraffin oils) and combinations thereof.
- the oil components of the biphasic cosmetic composition according to the invention are advan tageously selected from a group consisting of lecithins and fatty acid triglycerides, namely the triglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarbox- ylic acids of chain length from 8 to 24, in particular 12 to 18 carbon atoms.
- the fatty acid triglyc erides can, for example, advantageously be selected from a group consisting of synthetic, sem isynthetic and natural oils, such as, for example, olive oil, sunflower oil, soya oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheatgerm oil, grapeseed oil, safflower oil, evening primrose oil, macadamia nut oil and the like.
- synthetic, sem isynthetic and natural oils such as, for example, olive oil, sunflower oil, soya oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheatgerm oil, grapeseed oil, safflower oil, evening primrose oil, macadamia nut oil and the like.
- Further polar oil components can be selected from a group consisting of esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids of chain length from 3 to 30 carbon atoms with saturated and/or unsaturated, branched and/or unbranched alcohols of chain length from 3 to 30 carbon atoms, and also from a group consisting of esters of aromatic carboxylic acids with saturated and/or unsaturated, branched and/or unbranched alcohols of chain length from 3 to 30 carbon atoms.
- ester oils can then advantageously be selected from a group consisting of isopro pyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, dicaprylyl carbonate (for example Cetiol ® CC (com suddenly available from BASF)) and cocoglycerides (Myri)
- one or more oil components can advantageously be selected from a group con sisting of branched and unbranched hydrocarbons, such as Cio to Cis alkane, preferably un decane or tridecane or combination thereof (for example Cetiol ® Ultimate (commercially availa ble from BASF)), dialkyl ethers, such as dicaprylyl ether (for example Cetiol ® OE (commercially available from BASF)).
- branched and unbranched hydrocarbons such as Cio to Cis alkane, preferably un decane or tridecane or combination thereof (for example Cetiol ® Ultimate (commercially availa ble from BASF)
- dialkyl ethers such as dicaprylyl ether (for example Cetiol ® OE (commercially available from BASF)).
- one or more oil components can advantageously be selected from a group consist ing of fatty acid of 12 to 20 carbon atoms, preferably 14 to 18 carbon atoms, for example lauric acid, palmitic acid, myristic acid or stearic acid, preferably palmitic acid (for example EDENOR ® C16-98 MY BD (commercially available from Emery)).
- fatty acid 12 to 20 carbon atoms, preferably 14 to 18 carbon atoms, for example lauric acid, palmitic acid, myristic acid or stearic acid, preferably palmitic acid (for example EDENOR ® C16-98 MY BD (commercially available from Emery)).
- the oil component can also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components apart from the silicone oil or the silicone oils.
- Low molecular weight silicones or silicone oils are generally defined by the following general formula
- Silicon atoms may be substituted by identical or different alkyl radicals and/or aryl radicals, which are shown here in general terms by the radicals Ri to R4.
- the number of different radicals is not necessarily limited to up to 4. m can here assume values from 2 to 200 000.
- Cyclic silicones to be used advantageously according to the invention are generally defined by the following general formula: where the silicon atoms may be substituted by identical or different alkyl radicals and/or aryl radicals, which are shown here in general terms by the radicals Ri to R4.
- the number of different radicals is not necessarily limited to up to 4.
- n can here assume values from 3/2 to 20. Fractional values for n take into consideration that odd numbers of siloxyl groups may be present in the cycle.
- Phenyltrimethicone is advantageously selected as silicone oil.
- silicone oils for example dimethicone, hexamethylcyclotrisiloxane, phenyldimethicone, cyclomethicone (for example dec- amethylcyclopentasiloxane, cyclopentasiloxanecyclohexasiloxane), hexamethylcyclotrisiloxane, polydimethylsiloxane, poly(methylphenylsiloxane), cetyldimethicone, behenoxydimethicone, are also to be used advantageously within the context of the present invention. Mixtures of cyclome thicone and isotridecyl isononanoate, and also those of cyclomethicone and 2-ethylhexyl isos tearate are also advantageous.
- silicone oils of similar constitution to that of the abovementioned compounds whose organic side chains are derivatized, for example polyeth- oxylated and/or polypropoxylated.
- silicone oils include, for example, polysiloxane polyalkyl-polyether copolymers, such as, for example, cetyl-dimethicone copolyol.
- the oil components are selected from a group consisting of esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids of chain length from 3 to 30 carbon atoms with saturated and/or unsaturated, branched and/or un branched alcohols of chain length from 3 to 30 carbon atoms, and also from a group consisting of esters of aromatic carboxylic acids with saturated and/or unsaturated, branched and/or un branched alcohols of chain length from 3 to 30 carbon atoms, preferably from a group consist ing of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stea rate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate
- the oil components may be present in an amount of from 1 to 20 wt%, preferably from 2 to 18 wt%, more preferably from 3 to 16 wt%, further more preferably from 3 to 12 wt%, based on the total weight of the biphasic cosmetic composition.
- the biphasic cosmetic composition according to the present invention comprises fatty alcohol having from 6 to 22 carbon atoms.
- Suitable fatty alcohols for use in the biphasic cosmetic composition herein are selected from a group consisting of saturated or unsaturated, branched or unbranched alcohols having from 6 to 22, preferably from 10 to 20, more preferably from 12 to 18 carbon atoms, such as Guerbet al cohols, including 2-butyloctanol (commercially available, for example, as lsofol ® 12 (Condea)), 2- hexyldecanol (commercially available, for example as lsofol ® 16 (Condea)), mixtures of 2- butyloctanol and 2-hexyldecanol (commercially available, for example, as lsofol ® 14 (Condea)), cetyl alcohol, stearyl alcohol, cetearyl alcohol (for example Lanette ® O (commercially available from BASF)), oleyl alcohol, octyldodecanol (for example Eutanol ® G (commercially available from
- the weight ratio of the fatty alcohol polyoxyalkylene ethers to fatty alcohols is 1 :10 to 10:1, preferably 1 :8 to 5:1, more preferably 1 : 5 to 1:1.
- the biphasic cosmetic compositions according to the invention comprise the fatty alcohol polyoxyalkylene ether and at least one surfactant selected from a group con sisting of anionic surfactant and amphoteric surfactant.
- the biphasic cosmetic composition according to the present invention comprises fatty alcohol polyoxyalkylene ether, fatty alcohol having from 6 to 22 carbon atoms, and at least one surfactant selected from a group consisting of anionic surfactant and amphoteric surfactant, wherein preferably the fatty alcohol polyoxyalkylene ether is present in an amount of from 0.001 to 1.0 wt%, based on the total weight of the biphasic cosmetic compo sition.
- composition of the present invention may comprise any anionic surfactants which are commonly used in cosmetic composition.
- anionic surfactants include sulfate anionic surfactants, aminoacid anionic surfactants, sulfosuccinate anionic surfactants and sulfonated fatty acid and/or disalt anionic surfactants.
- Non-limiting examples of suitable sulfate anionic surfactants include ammonium lauryl sulfate, ammonium laureth sulfate, triethylamine lauryl sulfate, triethylamine laureth sulfate, monoeth- anolamine lauryl sulfate, monoethanolamine laureth sulfate, diethanolamine lauryl sulfate, di ethanolamine laureth sulfate, triethanolamine lauryl sulfate, triethanolamine laureth sulfate, lau- ric monoglyceride sodium sulfate, sodium lauryl sulfate, sodium laureth sulfate, potassium lauryl sulfate, potassium laureth sulfate, ammonium cocoyl sulfate, ammonium lauroyl sulfate, sodium cocoyl sulfate, sodium lauroyl sulfate, potassium coco
- Non-limiting examples of suitable aminoacid anionic surfactants include acyl glutamate salts, acyl taurate salts, acyl glycinate salts, acyl alaninate salts, acyl sarcosinate salts and acyl as partate salts.
- the salts include alkali metal salts such as sodium salt (Na) and po tassium salt (K); alkaline earth metal salts, such as calcium (Ca) and magnesium (Mg) salts; triethanolamine salts (TEA); an ammonium salt; and so on. More preferred are, for example, potassium salts, sodium salts, triethanolamine salts and ammonium salts, in particular sodium salts.
- the acyl glutamate salts include cocoyl glutamate, lauroyl glutamate, myristoyl glu tamate, palmitoyl glutamate, stearoyl glutamate, hydrogenated tallow acyl glutamate, olive oil acyl glutamate and octanoyl glutamate, for example, sodium cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium palmitoyl glutamate, sodium stearoyl glutamate, disodium cocoyl glutamate, disodium stearoyl glutamate, potassium cocoyl glutamate, potassi um lauroyl glutamate, and potassium myristoyl glutamate, more preferably sodium cocoyl glu tamate and sodium stearoyl glutamate (for example Plantapon ® Amino SCG-L (commercially available from BASF), Plantapon ® Amino SLG-P (I NCI :
- the acyl taurate salts include cocoyl taurates, cocoyl methyl taurates, lauric taurates, lauroyl methyl taurates, stearoyl methyl taurates, myristoyl methyl taurates, palmitoyl methyl taurates, oleoyl methyl taurates, hexanoyl methyl taurates, and lauroyl methyl beta-alanine tau rates.
- Particularly preferred are, for example, cocoyl taurates, cocoyl methyl taurate, lauric acid taurates, lauroyl taurates and lauroyl methyl taurates.
- sodium tau rine cocoyl methyl taurate for example NEOSCOAP CDT-30 (CR), NEOSCOAPCDT-30- SF(CR), NEOSCOAP CDT-30-SF, NEOSCOAP CN-30(CR), and NEOSCOAP CN-30-SF (commercially available from Toho Chemical Industry)
- the acyl glycinate salts include cocoyl glycinate, palmitoyl glycinate, octanoyl glycinate and undecylenoyl glycinate. Even more preferred are, for example, cocoyl glycinate. Particularly preferred are, for example, potassium cocoyl glycinate (Plantapon ® Amino KG-L and Plantapon ® Amino KG-P, commercially available from BASF) and sodium cocoyl glycinate, more preferably sodium cocoyl glycinate.
- the acyl alaninate salts include cocoyl alaninate, cocoyl methyl alaninate, lauroyl methyl alaninate, and myristoyl methyl alaninate. Even more preferred are, for example, cocoyl alaninate, cocoyl methyl alaninate and lauroyl methyl alaninate. Particularly preferred are, for example, sodium cocoyl alaninate, TEA cocoyl alaninate, sodium cocoyl methyl alaninate, sodi um lauroyl methyl alaninate and TEA lauroyl methyl alaninate, more preferably sodium cocoyl alaninate.
- the acyl sarcosinate salts include cocoyl sarcosinate, lauroyl sarcosinate, myristoyl sarcosinate, palmitoyl sarcosinate, and oleoyl sarcosinate. Particularly preferred are, for exam ple, cocoyl sarcosinate and lauroyl sarcosinate.
- potassium cocoyl sarcosinate sodium cocoyl sarcosinate, TEA cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium lauroyl sarcosinate and TEA lauroyl sarcosinate, more preferably sodium cocoyl sarcosinate.
- the acyl aspartate salts include palmitoyl aspartate, myristyl aspartate, lauryl aspar tate, and lauroyl aspartate. Even more preferred are, for example, lauryl aspartate and lauroyl aspartate. Particularly preferred are potassium lauryl aspartate, sodium lauryl aspartate, TEA lauryl aspartate and sodium lauroyl aspartate, more preferably sodium lauroyl aspartate.
- Non-limiting examples of suitable sulfosuccinate anionic surfactants include dioctyl sodium sul- fosuccinate, disodium laureth sulfosuccinate, disodium lauryl sulfosuccinate, disodium cetearyl sulfosuccinate, disodium undecyleneamido MEA sulfosuccinate and disodium PEG-5 lauryl cit rate sulfosuccinate, preferably disodium lauryl sulfosuccinate and disodium cetearyl sulfosuc cinate, more preferably disodium cetearyl sulfosuccinate (for example Eumulgin ® Prisma (com conciseally available from BASF)).
- suitable sulfosuccinate anionic surfactants include dioctyl sodium sul- fosuccinate, disodium laureth sulfosuccinate, disodium lauryl
- Non-limiting examples of suitable sulfonated fatty acid and/or disalt anionic surfactants are compounds of the formula (1)
- R° is saturated, linear Cs to Cie hydrocarbon chain, preferably saturated, linear Cio to C M hydrocarbon chain.
- M 1 and M 2 are Na.
- the sulfonated fatty acid and/or disalt anionic surfactant is disodium 2- sulfolaurate (for example Texapon ® SFA (commercially available from BASF)).
- the anionic surfactants may be present in an amount of from 0.001 to 5 wt%, preferably from 0.005 to 1 wt%, further preferably from 0.006 to 0.5 wt%, more preferably from 0.01 to 0.1 wt%, most preferably from 0.04 to 0.1 wt%, based on the total weight of the biphasic cosmetic com position.
- Non-limiting examples of suitable amphoteric surfactants include sodium acyl amphoacetate, disodium acyl amphodipropionate, disodium alkyl amphodiacetate, sodium acyl amphohydroxy- propylsulfonate, disodium acyl amphodiacetate, sodium acyl amphopropionate, and N-coconut fatty acid amidoethyl N-hydroxyethylglycinate sodium salts.
- Further advantageous amphoteric surfactants are N-alkylamino acids, for example aminoprop- ylalkylglutamide, alkylaminopropionic acid, sodium alkylimidodipropionate and lauroamphocar- boxyglycinate.
- Suitable amphoteric surfactants are also, for example, alkylbetaines, alkylamidopropylbetaines, alkylsulfobetaines, alkyl glycinates, alkylcarboxyglycinates, alkyl amphoacetates or -propionates, alkyl amphodiacetates or -dipropionates, preferably cocodimethylsulfopropylbetaine, laurylbeta- ine, cocamidopropyl betaine or sodium cocamphopropionate, more preferably cocamidopropyl betaine (for example Dehyton ® PK 45 (commercially available from BASF), Dehyton ® KE-AS (commercially available from BASF), Dehyton ® K/I5 (commercially available from BASF), Dehy ton ® DC-AS, Dehyton ® ML, TEGO ® Betain P 50 C (commercially available from Evonik), TEGO ® Betain
- amphoteric surfactants may be present in an amount of from 0.001 to 5 wt%, preferably from 0.005 to 1 wt%, further preferably from 0.006 to 0.5 wt%, more preferably from 0.01 to 0.1 wt%, most preferably from 0.04 to 0.1 wt%, based on the total weight of the biphasic cosmetic composition.
- the biphasic cosmetic compositions according to the invention further comprise the following other ingredients.
- Suitable humectants for the biphasic cosmetic compositions according to the invention are eth- oxylated or non-ethoxylated mono-alcohols, diols or polyols with a low number of carbon atoms or their ethers (e.g.
- ethanol isopropanol, 1,2-dipropanediol, propyleneglycol, glyerin, ethylene glycol, ethylene glycol monoethylether, ethylene glycol monobutylether (butyl glycol), propylene glycol monomethylether, propylene glycol monoethylether, propylene glycol monobutylether, diethylene glycol monomethylether; diethylene glycol monoethylether, diethylene glycol mono butylether and similar products).
- the polyols that come into consideration for that purpose have preferably from 2 to 15 carbon atoms and at least two hydroxy groups.
- the polyols may also contain further functional groups, especially amino groups, and/or may be modified with nitro gen.
- Typical examples are as follows: glycerol, alkylene glycols, for example ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and also polyethylene gly cols having an average molecular weight of from 100 to 1000 Dalton (for example Pluracare ® E 400 (commercially available from BASF)); technical oligoglycerol mixtures having an intrinsic degree of condensation of from 1.5 to 10, for example technical diglycerol mixtures having a diglycerol content of from 40 to 50 wt%; methylol compounds, such as, especially, trime- thylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol; lower alkyl-glucosides, especially those having from 1 to 8 carbon atoms in the alkyl radical, for ex ample methyl and butyl glucoside; sugar alcohols having from 5 to 12 carbon atoms
- the humectant may be present in an amount of from 0.01 to 30 wt%, preferably from 0.1 to 15 wt%, more preferably from 1 to 5 wt%, based on the total weight of the biphasic cosmetic com position.
- Suitable chelating agents for the biphasic cosmetic compositions according to the invention may be selected from the group consisting of ethylenediamine tetraacetic acid (EDTA), dipotassium EDTA, disodium EDTA, tetrasodium EDTA, diammonium EDTA, calcium disodium EDTA, TEA- EDTA, tripotassium EDTA, trisodium EDTA, hydroxy ethyl ethylenediamine triacetic acid (HEDTA), trisodium HEDTA, and combinations thereof.
- the chelating agent comprises disodium EDTA (for example Edeta ® BD (commercially available from BASF)).
- the chelating agents may be present in an amount of from 0.001 to 1 wt%, preferably from 0.01 to 1.0 wt%, more preferably from 0.05 to 0.5 wt%, based on the total weight of the biphasic cosmetic composition.
- Suitable thickeners for the biphasic cosmetic compositions according to the invention are poly saccharides, preferably xanthan gum (for example Rheocare ® XGN (commercially available from BASF)), guar gum, agar, alginates or tyloses, cellulose derivatives, for example hydroxy- alkylcellulose, wherein alkyl is a CrC4-alkyl, particularly hydroxyethyl-cellulose, preferably the NatrosolTM trademarks, especially preferably NatrosolTM 250 (CAS-Nr.
- xanthan gum for example Rheocare ® XGN (commercially available from BASF)
- guar gum agar
- alginates or tyloses cellulose derivatives
- cellulose derivatives for example hydroxy- alkylcellulose, wherein alkyl is a CrC4-alkyl, particularly hydroxyethyl-cellulose, preferably the NatrosolTM trademarks, especially preferably NatrosolTM 250 (CAS-N
- Suitable thickeners are also polyacrylates, crosslinked polyacrylic acids and derivatives thereof, such as Tinovis ® CD, and Rheocare ® TTA (commercially available from BASF), Carbopol ® (commercially available from Lubrizol), Ultrez ® (commercially available from Lubrizol), Luvigel ® EM (commercially available from BASF), Cosmedia ® SP (commercially available from BASF), Tinovis ® GTC UP (commercially available from BASF), Capigel ® 98 (commercially available from Seppic), Synthalene ® (commercially available from Sigma), the Aculyn ® grades from Rohm and Haas, such as Aculyn ® 22 (copolymer of acrylates and methacrylic acid ethoxylates with stearyl radical (20 ethylene oxide (EO) units)) and Aculyn ® 28 (copolymer of acrylates and methacrylic acid ethoxylates with behenyl radical (25 EO units)
- Suitable thickeners are furthermore, for example, aerosol grades (hydrophilic silicas), poly acrylamides, polyvinyl alcohol and polyvinylpyrrolidone, ethoxylated fatty acid glycerides, esters of fatty acids with polyols, such as, for example, pentaerythritol or trimethylolpropane, fatty al cohol ethoxylates with a narrowed homolog distribution or alkyl oligoglucosides, and also elec trolytes such as sodium chloride and ammonium chloride.
- the thickeners may be present in a conventional amount in the art and depending on their types. The person skilled in the art will be able to select the appropriate thickener and amount for the present invention.
- the thickeners may be present in an amount of from 0.01 to 3 wt%, preferably from 0.02 to 2.0 wt%, more preferably from 0.04 to 1.5 wt%, based on the total weight of the biphasic cosmetic composition.
- Biphasic cosmetic compositions according to the invention can advantageously comprise one or more preservatives.
- Advantageous preservatives within the context of the present invention are, for example, for maldehyde donors (such as, for example, DM DM hydantoin, which is commercially available, for example, under the trade name Glydant ® (commercially available from Lonza)), iodopropyl bu- tylcarbamates (for example Glycacil-L ® , Glycacil-S ® (commercially available from Lonza), Deka- ben ® LMB (commercially available from Jan Dekker)), parabens (p-hydroxybenzoic acid alkyl esters, such as, for example, methyl, ethyl, propyl and/or butylparaben), dehydroacetic acid (Euxyl ® K 702 (commercially available from Schulke & Mayr), phenoxyethanol, ethanol, benzoic acid, or combination thereof. So-called preservation aids, such as, for example, octoxyglycerol
- preservatives or preservation aids customary in cosmetics such as di- bromodicyanobutane (2-bromo-2-bromomethylglutarodinitrile), phenoxyethanol, 3-iodo-2- propynyl butylcarbamate, 2-bromo-2-nitropropane-1,3-diol, imidazolidinylurea, 5-chloro-2- methyl-4-isothiazolin-3-one, 2-chloroacetamide, benzyl alcohol, salicylic acid and salicylates.
- the preservatives may be present in an amount of from 0.01 to 5 wt%, preferably from 0.1 to 2 wt%, more preferably from 0.2 to 1 wt%, based on the total weight of the biphasic cosmetic composition.
- the biphasic cosmetic compositions according to the invention can comprise per fume oils.
- Perfume oils which may be mentioned are, for example, mixtures of natural and syn thetic fragrances. Natural fragrances are extracts from flowers (lily, lavender, rose, jasmine, neroli, Ylang-Ylang), stems and leaves (geranium, patchouli, petit grain), fruits (anis, coriander, caraway, juniper), fruit peels (bergamot, lemon, orange), roots (mace, angelica, celery, carda mom, costus, iris, calmus), woods (pinewood, sandalwood, guaiac wood, cedarwood, rose wood), herbs and grasses (tarragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, dwarf-pine), resins and balsams (galbanum, elemi, benzoe, myrrh, olibanum, opoponax).
- Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alco hol and hydrocarbon type. Fragrance compounds of the ester type are, for example, benzyl ace tate, phenoxyethyl isobutyrate, 4-tert-butyl cyclohexyl acetate, linalyl acetate, dimethylbenzyl- carbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethylmethyl phenyl- glycinate, allyl cyclohexylpropionate, styrallyl propionate and benzyl salicylate.
- the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonat
- the ketones include, for example, the ionones, cc- isomethylions and methyl cedryl ketone
- the alcohols include anethol, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terioneol
- the hydrocarbons include primarily the terpenes and balsams.
- fragrance oils which are mostly used as aroma components, are also suitable as perfume oils, for example sage oil, chamomile oil, oil of cloves, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, labolanum oil and lavandin oil.
- the perfume oils may be present in the biphasic cosmetic composition in a conventional amount.
- the biphasic cosmetic composition of the invention should be cosmetically or dermatologically acceptable, i.e. , it should contain a non-toxic physiologically acceptable medi um and should be able to be applied to the skin.
- the expres sion "cosmetically acceptable" means a composition of pleasant appearance, odor, feel and/or taste.
- the present invention provides a process for preparing the biphasic cosmet ic composition according to the invention, comprising mixing the components of the biphasic cosmetic composition.
- the biphasic cosmetic composition according to the invention is prepared by combining pre mixed components of oily phase and aqueous phase other than fatty alcohol polyoxyalkylene ethers and surfactants (if used) in a predetermined ratio and then adding fatty alcohol polyoxy alkylene ethers and surfactants (if used), to form a biphasic composition.
- the com ponents of the biphasic cosmetic composition are added, together or in sequence, with agitation to facilitate segregation of each ingredient into the appropriate phase.
- the present invention provides a biphasic cosmetic composition comprising cosmetically active ingredients which are stably present in the composition.
- active ingredients of varying solubility can be homogeneously incorpo rated into the biphasic cosmetic compositions according to the invention.
- the active ingredients can advantageously be selected from a group of NO synthase inhibitors, particularly if the biphasic cosmetic compositions according to the invention are to serve for the treatment and prophylaxis of the symptoms of intrinsic and/or ex trinsic aging and also for the treatment and prophylaxis of the harmful effects of ultraviolet radia tion on the skin.
- a preferred NO synthase inhibitor is nitroarginine.
- the active ingredients are advantageously selected from a group consisting of cat- echins and bile acid esters of catechins and aqueous or organic extracts from plants or parts of plants which have a content of catechins or bile acid esters of catechins, such as, for example, the leaves of the plant family Theaceae, in particular of the species Camellia sinensis (green tea).
- Their typical ingredients for example polyphenols or catechins, caffeine, vitamins, sugars, minerals, amino acids, lipids are particularly advantageous.
- Catechins are a group of compounds which are to be regarded as hydrogenated flavones or anthocyanidins and are derivatives of "catechins” (catechol, 3,3',4',5,7-flavanpentaol, 2-(3,4- dihydroxyphenyl)chroman-3,5,7-triol).
- Catatechin ((2R,3R)-3,3',4',5,7-flavanpentaol) is also an advantageous active ingredient within the context of the present invention.
- plant extracts with a content of catechins in particular extracts of green tea, such as, for example, extracts from leaves of the plants of the Camellia spec species, very particularly of the tea varieties Camellia sinenis, C. assamica, C. taliensis and C. inawadiensis and hybrids of these with, for example, Camellia japonica.
- Preferred active ingredients are also polyphenols and catechins from a group consisting of (-) catechin, (+)-catechin, (-)-catechin gallate, (-)-gallocatechin gallate, (+)-epicatechin, (-)- epicatechin, (-)-epicatechin gallate, (-)-epigallocatechin, (-)-epigallocatechin gallate.
- Flavone and its derivatives are also advantageous ac tive ingredients within the context of the present invention.
- active ingredients are sericoside, pyridoxol, vitamin K, biotin and aroma sub stances, bisabolol (bisabolol rac. (commercially available from BASF)), tocopherol (Covi-ox ® T- 50 C (commercially available from BASF)), retinyl palmitate (Vitamin A-Palmitate Care (com briefly available from BASF)), retinol (Retinol 50 C (commercially available from BASF)), Schizandra Chinensis Fruit Extract (Sqisandryl ® LS 9905 (commercially available from BASF)).
- the active ingredients can also very advantageously be selected from a group of hydrophilic active ingredients, in particular from the following group: a-hydroxy acids, such as lactic acid or salicylic acid and salts thereof, such as, for example, Na- lactate, Ca-lactate, TEA-lactate, urea, allantoin, serine, sorbitol, milk proteins, panthenol, chi- tosan, glycerin and glyceryl glucoside (for example Hydagen ® Aquaporin (commercially availa ble from BASF)) or combination thereof.
- a-hydroxy acids such as lactic acid or salicylic acid and salts thereof, such as, for example, Na- lactate, Ca-lactate, TEA-lactate, urea, allantoin, serine, sorbitol, milk proteins, panthenol, chi- tosan, glycerin and glyceryl glucoside (for example Hydagen ® Aqua
- the list of specified active ingredients and active ingredient combinations which can be used in the biphasic cosmetic compositions according to the invention is not of course intended to be limiting.
- the active ingredients can be used individually or in any combinations with one another.
- the active ingredients may be present in the biphasic composition of the present invention in a conventional amount in the art depending on their types. The person skilled in the art will be able to select the appropriate active ingredients and amounts for the present invention.
- compositions of the present invention may further comprise one or more benefit agents that can provide a positive and/or beneficial effect to the substrate being cared, e.g. to the skin.
- benefit agents that can provide a positive and/or beneficial effect to the substrate being cared, e.g. to the skin.
- the skilled person in the art is able to select according to general knowledge in the art of formulating cosmetic compositions, and the vast literature there-related, appropriate such optional ingredi ents for application purposes.
- the composition of the present invention further comprises one or more benefit agents, such as emollients, moisturizers, conditioners, skin conditioners, such as vita mins or their derivatives, such as vitamin B complex, including thiamine, nicotinic acid, biotin, pantothenic acid, choline, riboflavin, vitamin B6, vitamin B12, pyridoxine, inositol, carnitine, vit amins A, C, D, E, K and their derivatives, such as vitamin A palmitate, and pro-vitamins, e.g., panthenol (pro vitamin B5), panthenol triacetate and mixtures thereof; antioxidants; free-radical scavengers; abrasives, natural or synthetic; dyes; hair coloring agents; bleaching agents; hair bleaching agents; UV absorbers, such as benzophenone, bornelone, PABA (Para Amino Ben zoic Acid), butyl PABA, c
- vitamin A analogs such as esters of vitamin A, including vitamin A palmitate, retinoids, retinols, and retinoic acid, corticosteroids such as hydrocortisone, clobetasone, butyr ate, clobetasol propionate; antiperspirants or deodorants, such as aluminum chlorohydrates, aluminum zirconium chlorohydrates; immunomodulators; nourishing agents; depilating agents, such as calcium thioglycolate, magnesium thioglycolate, potassium thioglycolate, strontium thi- oglycolate; agents for combating hair loss; reducing agents for permanent-waving; reflectants, such as mica, alumina, calcium silicate, glycol dioleate, glycol distearate, silica, sodium magne sium fluorosilicate; essential oils and fragrances.
- vitamin A analogs such as esters of vitamin A, including vitamin A palmitate, retinoids, retino
- the pH of the compositions of the invention can be conventionally adjusted to for example from 4.0 to 7.0, preferably from 4.5 to 6.5, more preferably from 5.0 to 6.0.
- the present invention provides the use of the biphasic cosmetic composition according to the invention as a delivery system for cosmetically active ingredients.
- At least one of the oily phase and aqueous phase contains an active ingredient that is cosmetically active on the skin.
- active ingredients it should be understood that suitable active ingredients as well as their amount in the composition are the same as those described hereinabove.
- the present invention provides a process for applying the biphasic cosmetic composition comprising cosmetically active ingredients according to the invention, comprising shaking the composition to form a macroscopically homogeneous mixture and applying the mix ture to skin.
- the biphasic cosmetic composition according to the present invention can simultaneously deliver aqueous-based and oil-based ingredients to skin with a very soft and fresh sensory.
- the biphasic cosmetic composition according to the present invention can deliver the components of each phase in a way that retains the benefits of each with reduced amounts of oily components.
- the biphasic cosmetic composition according to the present invention con tains reduced amounts of surfactant that might have unintended deleterious effects on the skin and bioaccumulation problems. Examples
- Biphasic cosmetic compositions are prepared as follows and the weight percentages of the ma terials are shown in Tables below. 1. Under agitation, adding the components of oily phase to the components of aqueous phase at a temperature of 75 to 80°C, then homogenizing for several minutes to form a uniform solu tion.
- the transparency of the aqueous phase of the biphasic cosmetic composition can be verified visually.
- Phase A includes the components of aquous phase
- Phase B includes the components of oily phase
- Phase C includes fatty alcohol polyoxyalkylene ethers and surfactants
- Phase D includes active in gredients.
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020237036726A KR20240001697A (en) | 2021-04-28 | 2022-03-28 | Biphasic cosmetic compositions and their applications |
JP2023565865A JP2024515225A (en) | 2021-04-28 | 2022-03-28 | Two-phase cosmetic composition and its uses |
CN202280031997.XA CN117769408A (en) | 2021-04-28 | 2022-03-28 | Dual-phase cosmetic composition and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CNPCT/CN2021/090607 | 2021-04-28 | ||
CN2021090607 | 2021-04-28 |
Publications (1)
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WO2022228806A1 true WO2022228806A1 (en) | 2022-11-03 |
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PCT/EP2022/058147 WO2022228806A1 (en) | 2021-04-28 | 2022-03-28 | Biphasic cosmetic composition and application thereof |
Country Status (4)
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JP (1) | JP2024515225A (en) |
KR (1) | KR20240001697A (en) |
CN (1) | CN117769408A (en) |
WO (1) | WO2022228806A1 (en) |
Citations (6)
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---|---|---|---|---|
EP0370856B2 (en) * | 1988-11-09 | 1995-08-30 | L'oreal | Eye make-up remover with two distinct phases |
DE10318526A1 (en) | 2003-04-24 | 2004-11-11 | Beiersdorf Ag | High fat cleaning emulsion |
US20070155637A1 (en) * | 2005-04-13 | 2007-07-05 | Smith Edward D Iii | Structured multi-phased personal cleansing composition comprising branched anionic surfactants |
EP1708678B1 (en) * | 2004-07-02 | 2009-04-15 | Natura Cosméticos S.A. | Cosmetic composition comprising a lipid fraction from vegetal source and anticrystallizing agent |
US20150190317A1 (en) * | 2012-07-16 | 2015-07-09 | L'oreal | Two-phase composition containing an alkylpolyglucoside and an ester with a melting point of less than 10°c |
FR3060332A1 (en) * | 2016-12-16 | 2018-06-22 | L'oreal | CONDITIONING MULTIPHASIC COMPOSITION WITH SHAMPOO EFFECT |
-
2022
- 2022-03-28 WO PCT/EP2022/058147 patent/WO2022228806A1/en active Application Filing
- 2022-03-28 KR KR1020237036726A patent/KR20240001697A/en unknown
- 2022-03-28 JP JP2023565865A patent/JP2024515225A/en active Pending
- 2022-03-28 CN CN202280031997.XA patent/CN117769408A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0370856B2 (en) * | 1988-11-09 | 1995-08-30 | L'oreal | Eye make-up remover with two distinct phases |
DE10318526A1 (en) | 2003-04-24 | 2004-11-11 | Beiersdorf Ag | High fat cleaning emulsion |
EP1708678B1 (en) * | 2004-07-02 | 2009-04-15 | Natura Cosméticos S.A. | Cosmetic composition comprising a lipid fraction from vegetal source and anticrystallizing agent |
US20070155637A1 (en) * | 2005-04-13 | 2007-07-05 | Smith Edward D Iii | Structured multi-phased personal cleansing composition comprising branched anionic surfactants |
US20150190317A1 (en) * | 2012-07-16 | 2015-07-09 | L'oreal | Two-phase composition containing an alkylpolyglucoside and an ester with a melting point of less than 10°c |
FR3060332A1 (en) * | 2016-12-16 | 2018-06-22 | L'oreal | CONDITIONING MULTIPHASIC COMPOSITION WITH SHAMPOO EFFECT |
Non-Patent Citations (5)
Title |
---|
DATABASE GNPD [online] MINTEL; 1 February 2011 (2011-02-01), ANONYMOUS: "Scented Moisturiser with Ruby Jelly", XP055847744, retrieved from https://www.gnpd.com/sinatra/recordpage/1482192/ Database accession no. 1482192 * |
DATABASE GNPD [online] MINTEL; 11 December 2008 (2008-12-11), ANONYMOUS: "Biphasic Body Lotion", XP055847749, retrieved from https://www.gnpd.com/sinatra/recordpage/1017431/ Database accession no. 1017431 * |
DATABASE GNPD [online] MINTEL; 27 October 2008 (2008-10-27), ANONYMOUS: "Biphase Body Oil", XP002804406, retrieved from https://www.gnpd.com/sinatra/recordpage/992732/ Database accession no. 992732 * |
DATABASE GNPD [online] MINTEL; 7 July 2015 (2015-07-07), ANONYMOUS: "Moisturising Biphasic Cream", XP055847745, retrieved from https://www.gnpd.com/sinatra/recordpage/3287777/ Database accession no. 3287777 * |
KARL-HEINZ SCHRADER: "Fundamentals and Formulations of Cosmetics", VERLAG HUTHIG, article "Grundlagen und Rezepturen der Kosmetika", pages: 319 - 355 |
Also Published As
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JP2024515225A (en) | 2024-04-05 |
KR20240001697A (en) | 2024-01-03 |
CN117769408A (en) | 2024-03-26 |
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