WO2022120807A1

WO2022120807A1 - Immune system regulation method and ultrasonic immunotherapy device

Info

Publication number: WO2022120807A1
Application number: PCT/CN2020/135773
Authority: WO
Inventors: 郑海荣; 周慧; 牛丽丽; 孟龙; 夏向向; 庞娜
Original assignee: 深圳先进技术研究院
Priority date: 2020-12-11
Filing date: 2020-12-11
Publication date: 2022-06-16

Abstract

An immune system regulation method and an ultrasonic immunotherapy device. The immune system regulation method comprises the steps of generating ultrasonic waves of specific parameters, transmitting same to a target human body tissue and organ, performing activation or suppression, etc. Also provided is a device structure for implementing immune system regulation. For different immune nervous systems, specific ultrasonic waves are generated and directed onto the nerve nuclei of a target nervous system to stimulate a central or peripheral system, so as to produce an activation or suppression immune effect, thereby achieving the purpose of immunotherapy of diseases.

Description

A kind of immune system regulation method and ultrasonic immunotherapy device

technical field

The invention belongs to the technical field of immunotherapy devices, and in particular relates to an immune system regulation method and an ultrasonic immunotherapy device.

Background technique

"Cancer immunotherapy" was named the best scientific breakthrough by major academic journals in 2013, and two scientists who proposed tumor immunotherapy were also awarded the 2018 Nobel Prize in Physiology or Medicine. Immunotherapy is to treat the disease by improving or suppressing the patient's own immune system.

The current immunotherapy method is drug treatment. For example, two tumor immunotherapy methods (immune checkpoint blockade therapy and chimeric antigen receptor T cell therapy) have been studied in many reports. point inhibitors, receptors) to achieve the recognition and attack of cancer cells by immune cells. The drugs used in these treatment methods not only have a long development cycle and high cost, but also bring huge economic burdens to patients during the treatment process.

Ultrasound focused therapy is a brand-new treatment method, and there have been reports of the application of this technology in some disease treatment fields. However, there is no report on the mature application of ultrasonic technology to regulate the immune system and achieve the purpose of pre-treatment of diseases such as cancer.

SUMMARY OF THE INVENTION

In order to overcome the above-mentioned defects of the prior art, the present invention proposes an immune system regulation method and an ultrasonic immunotherapy device by developing and improving the existing ultrasonic imaging system and combining with the theory of immunotherapy, which can be put into use quickly and have low manufacturing cost. , the cost of treatment for patients is also greatly reduced.

Specifically through the following technical solutions:

An immune system regulation method for regulating the immune system, the immune system regulation method comprising:

S01: According to the purpose of immune system regulation, adjust ultrasonic parameters to generate and emit ultrasonic waves;

S02: According to the position and area of the target point, directional adjustment of the transmission direction of the ultrasonic wave;

S03: Focus and conduct the ultrasonic wave to the target point.

Specifically, the purpose of the immune regulation is to activate the immune effect or suppress the immune effect.

Specifically, the target location is the brain or an immune organ.

Specifically, in step S03, a coupling agent or deionized water is used for conduction.

An ultrasonic immunotherapy device, comprising:

Ultrasonic electronic phased array module is used to generate specific electrical pulse signals to adjust ultrasonic parameters according to the purpose of immune system regulation;

an ultrasonic surface array generator, used for generating and transmitting ultrasonic waves according to the ultrasonic parameters set by the ultrasonic electronic phased array module;

The guiding and fixing module is used for fixing the ultrasonic area array generator, so as to guide and focus the ultrasonic wave on the target point.

Further, the ultrasonic immunotherapy device further includes a data processing unit, which is used for activating or inhibiting the target point according to the parameters of the analysis of the specific pulse waveform, and sending out according to the activation or inhibition. Waveform adjustment instructions are sent to the ultrasonic phased array module to adjust the parameters of a specific pulse waveform.

Specifically, the ultrasonic electronic phased array module includes:

A signal transmitting circuit is used to generate an electrical pulse signal with a specific pulse waveform;

a power amplifying circuit, electrically connected to the signal transmitting circuit, for power amplifying the electrical pulse signal of the specific pulse waveform;

an electronic phase control circuit, electrically connected to the data processing unit, the signal transmitting circuit and the power amplifying circuit, for processing the electrical pulse signal after power amplification to have a preset depth and a preset number of Focusing the electrical pulse signal in the focal area, and controlling the signal transmitting circuit to adjust the parameters of the specific pulse waveform;

An impedance matching circuit, electrically connected with the ultrasonic area array generator and the electronic phase control circuit, is used for impedance matching with the ultrasonic area array generator, triggering the ultrasonic area array generator to convert the electrical pulse signal Convert to ultrasound with preset focus range and preset frequency range.

Specifically, the ultrasonic area array generator includes a backing block, a piezoelectric element, a matching layer, and an acoustic lens that are connected in sequence, and is electrically connected to the ultrasonic electronic phased array module through a cable; the piezoelectric element The number is multiple and forms an array.

Specifically, the guiding and fixing module includes a fixing bracket, a collimator, a water bladder and a circulating water module.

The present invention provides an immune system regulation method, which can generate specific ultrasonic waves for different immune tissues or organs and guide them to the target of the target nervous system, stimulate the central or peripheral system, and activate or suppress the immune effect to achieve immunotherapy. the purpose of the disease.

Description of drawings

In order to illustrate the technical solutions in the embodiments of the present application more clearly, the following briefly introduces the drawings that are used in the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort.

1 is a flow chart of a method for regulating an immune system provided by an embodiment of the present application;

2 is a schematic structural diagram of an ultrasonic immunotherapy device provided by an embodiment of the application;

Fig. 3 is another schematic diagram of the ultrasonic immunotherapy device provided by the embodiment of the application;

FIG. 4 is a schematic structural diagram of an ultrasonic electronic phased array module of an ultrasonic immunotherapy device provided by an embodiment of the present application.

FIG. 5 is a schematic structural diagram of an ultrasonic area array generator of an ultrasonic immunotherapy device provided by an embodiment of the present application.

Reference number:

1- Ultrasonic electronic phased array module, 2- Ultrasonic area array generator, 3- Guide fixed module, 4- Data processing unit, 101- Signal transmitting circuit, 102- Power amplifier circuit, 103- Electronic phased circuit, 104- Impedance matching circuit, 201-backing block, 202-piezoelectric element, 203-matching layer, 204-acoustic lens.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

This embodiment of the present application provides an immune system regulation method, which can emit specific ultrasonic waves to target functional areas of the central nervous system or peripheral nerves, and activate/inhibit the nervous system (central/peripheral) through non-invasive low-energy ultrasonic waves to achieve immunotherapy. Purpose,

The immune system regulation method includes:

S01: According to the purpose of regulating the immune system, adjust ultrasonic parameters to generate and emit ultrasonic waves.

Specifically, the purpose of the immune regulation is to activate the immune effect or suppress the immune effect. The target nervous system location is the brain or immune organs.

S02: According to the position and area of the target point, directional adjustment of the transmission direction of the ultrasonic wave is performed.

In the application, the ultrasonic focusing position is adjusted according to the position change information of the target target, so that the adjusted ultrasonic focusing position is the same as the target target. Further, ultrasonic waves can be used to direct the focused position to generate ultrasonic focal spots for ultrasonic stimulation and treatment.

S03: Focus and conduct the ultrasonic wave to the target point.

In the application, the error caused by the movement of the focus focal region can be corrected in real time during the ultrasonic stimulation control process. Through dynamic adjustment, the ultrasonic sound field can reach the target point, and the target point can be ultrasonically stimulated, so as to ensure that the point to be stimulated is obtained in real time. And precise ultrasound stimulation to achieve adaptive ultrasound stimulation. Specifically, in step S03, a coupling agent or deionized water may be used for conduction.

This embodiment also provides an ultrasonic immunotherapy device, which is used to realize the above-mentioned regulation method.

As shown in Figure 2, the ultrasonic immunotherapy device includes:

The ultrasonic electronic phased array module 1 is used to generate specific electrical pulse signals to adjust ultrasonic parameters according to the purpose of regulating the immune system;

The ultrasonic surface array generator 2 is used for generating and transmitting ultrasonic waves according to the ultrasonic parameters set by the ultrasonic electronic phased array module 1;

The guiding and fixing module 3 is used for fixing the ultrasonic area array generator 2, so as to guide and focus the ultrasonic waves on the target point.

Further, the ultrasonic immunotherapy device also includes a data processing unit 4, and the data processing unit 4 is used for activating and inhibiting the target point according to the parameters of analyzing the specific pulse waveform, and according to the activation and inhibition. The function is to issue a waveform adjustment command to the ultrasonic phased array module 1 to adjust the parameters of a specific pulse waveform.

The ultrasonic electronic phased array module 1 is realized based on ultrasonic phased array technology. For example, the ultrasonic phased array module may include, but is not limited to, a signal transmission circuit, a power amplifier circuit, an electronic phase control circuit, an impedance matching circuit, and the like. Specifically, the ultrasonic electronic phased array module includes:

a signal transmitting circuit 101 for generating an electrical pulse signal with a specific pulse waveform;

a power amplifying circuit 102, electrically connected to the signal transmitting circuit 101, for power amplifying the electrical pulse signal of the specific pulse waveform;

The electronic phase control circuit 103 is electrically connected to the data processing unit 4, the signal transmitting circuit 101 and the power amplifying circuit 102, and is used for processing the electrical pulse signal after power amplification to have a preset depth and a preset number of electric pulse signals focusing on the focal domain, and controlling the signal transmitting circuit to adjust the parameters of the specific pulse waveform;

The impedance matching circuit 104 is electrically connected with the ultrasonic area array generator 2 and the electronic phased circuit 103, and is used for impedance matching with the ultrasonic area array generator 2, triggering the ultrasonic area array generator 2 to The electrical pulse signal is converted into ultrasonic waves with a preset focus range and a preset frequency range.

In application, the preset focus range can be set according to the area of the specific functional area of the brain that requires intervention and treatment. The preset focus range is less than or equal to the area of the specific functional area that requires intervention and treatment. The preset frequency range can be set within a frequency range that can produce excitatory or inhibitory effects on specific functional areas that require intervention and treatment, but does not cause harm to specific functional areas.

In applications, parameters of a particular electrical pulse signal include pulse strength, pulse frequency, pulse repetition frequency, pulse amplitude, pulse width (or pulse length), pulse duration, and duty cycle (or pulse interval). The initial value of the parameter of the specific electrical pulse signal can be set according to the excitatory and inhibitory effects of the specific electrical pulse signal with different parameters on the specific functional area of the target nervous system.

In application, the preset depth can be set according to the depth of the specific functional area in the target nervous system that needs to be stimulated. The preset depth is equal to the depth of the specific functional area that requires stimulus modulation.

In application, the preset number can be set according to the number of specific functional areas in the target nervous system that need to be stimulated. The preset number is less than or equal to the number of specific functional areas that need to be stimulated and regulated. When the preset number is equal to the number of specific functional areas that need to be stimulated and regulated, the ultrasonic wave converted from the electrical pulse signal can be located in each specific functional area. A focal area is formed at the focal point, so as to achieve simultaneous stimulation and regulation of all specific functional areas; when the preset number is less than the number of specific functional areas that need to be stimulated and modulated, the ultrasonic waves can be respectively in the preset number of specific functional areas. A focusing focal area is formed at the position of each specific functional area, so as to realize the simultaneous stimulation and regulation of a preset number of specific functional areas. After completing the stimulation and regulation of a preset number of specific functional areas, the ultrasound can be focused to a preset number of In this way, batch stimulation regulation of all specific functional areas can be realized.

Specifically, the ultrasonic area array generator includes a backing block 201, a piezoelectric element 202, a matching layer 203, and an acoustic lens 204 connected in sequence, and is electrically connected to the ultrasonic electronic phased array module 1 through a cable; The piezoelectric elements 202 are plural in number and form an array.

Specifically, the guiding and fixing module 3 is used to adjust the parameter information of the ultrasonic wave according to the position and area of the target point, so as to change the transmission direction of the ultrasonic wave and conduct directional transmission, and project the focused ultrasonic focal spot of the ultrasonic wave on the target point. .

Specifically, the guiding and fixing module 3 may include a fixing bracket, a collimator, a water bladder and a circulating water module.

The guiding and fixing module 3 can correct the error caused by the movement of the focus focal region in real time during the ultrasonic stimulation regulation process, and through dynamic adjustment, the ultrasonic sound field can reach the target target point, and the target target point can be ultrasonically stimulated, so as to ensure the point to be stimulated. Get real-time and precise ultrasound stimulation to achieve adaptive ultrasound stimulation.

The present invention proposes an immune system regulation method, aiming at different immune nervous systems, generating specific ultrasonic waves and guiding them to the target point, stimulating the central or peripheral system, activating or inhibiting the immune effect, and achieving the purpose of immunotherapy of diseases.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection of the present invention. within the range.

Claims

An immune system regulation method for regulating the immune system, characterized in that the immune system regulation method comprises:

S01: According to the purpose of immune system regulation, adjust ultrasonic parameters to generate and emit ultrasonic waves;

S02: According to the position and area of the target point, directional adjustment of the transmission direction of the ultrasonic wave;

S03: Focus and conduct the ultrasonic wave to the target point.
The immune system regulation method according to claim 1, wherein the purpose of the immune regulation is to activate immune effect or inhibit immune effect.
The immune system regulation method according to claim 1, wherein the target location is the brain or an immune organ.
The immune system regulation method according to claim 1, wherein in step S03, a coupling agent or deionized water is used for conduction.
An ultrasonic immunotherapy device for implementing the immune system regulation method according to any one of claims 1 to 4, characterized by comprising:

Ultrasonic electronic phased array module is used to generate specific electrical pulse signals to adjust ultrasonic parameters according to the purpose of immune system regulation;

an ultrasonic surface array generator, used for generating and transmitting ultrasonic waves according to the ultrasonic parameters set by the ultrasonic electronic phased array module;

The guiding and fixing module is used for fixing the ultrasonic area array generator, so as to guide and focus the ultrasonic wave on the target point.
The ultrasonic immunotherapy device according to claim 5, characterized in that, the ultrasonic immunotherapy device further comprises a data processing unit, and the data processing unit is used for stimulating the target point according to a parameter of analyzing a specific pulse waveform and inhibition, and send waveform adjustment instructions to the ultrasonic phased array module according to the stimulation and inhibition, so as to adjust the parameters of a specific pulse waveform.
The ultrasonic immunotherapy device according to claim 6, wherein the ultrasonic electronic phased array module comprises:

A signal transmitting circuit, which is used to generate an electrical pulse signal with a specific pulse waveform;

a power amplifying circuit, electrically connected to the signal transmitting circuit, for power amplifying the electrical pulse signal of the specific pulse waveform;

an electronic phase control circuit, electrically connected to the data processing unit, the signal transmitting circuit and the power amplifying circuit, for processing the electrical pulse signal after power amplification to have a preset depth and a preset number of Focusing the electrical pulse signal in the focal domain, and controlling the signal transmitting circuit to adjust the parameters of the specific pulse waveform;

An impedance matching circuit, electrically connected with the ultrasonic area array generator and the electronic phase control circuit, is used for impedance matching with the ultrasonic area array generator, triggering the ultrasonic area array generator to convert the electrical pulse signal Convert to ultrasound with preset focus range and preset frequency range.
The ultrasonic immunotherapy device according to claim 5, wherein the ultrasonic area array generator comprises a backing block, a piezoelectric element, a matching layer, and an acoustic lens connected in sequence, and is connected with the ultrasonic wave through a cable. The electronic phased array module is electrically connected.
The ultrasonic immunotherapy device according to claim 8, wherein the piezoelectric elements are plural in number and form an array.
The ultrasonic immunotherapy device according to claim 5, wherein the guiding and fixing module comprises a fixing bracket, a collimator, a water bag and a circulating water module.