WO2021031355A1 - Method and apparatus for measuring pressure and ratio in wave-free period, and system and storage medium - Google Patents

Abstract

A method and apparatus for measuring pressure and ratio in a wave-free period, and a system and a storage medium. The method for measuring instantaneous coronary average pressure in a wave-free period comprises: collecting a real-time blood pressure value of a patient (S01); determining a wave-free period of the coronary artery of the patient (S02); and extracting the blood pressure value of the wave-free period according to the determined wave-free period of the coronary artery of the patient, and calculating the instantaneous coronary average pressure at the same moment as the blood pressure value according to the blood pressure value (S03). According to the method for measuring the instantaneous coronary average pressure in the wave-free period, the wave-free period can be determined and the real-time blood pressure value in the wave-free period of the patent can be collected clinically or in other ways without depending on an electrocardiogram only by means of the invasive pressure waveform, that is, the instantaneous coronary average pressure at the same moment as the blood pressure value can be obtained, the problem that the instantaneous coronary average pressure in the wave-free period can be measured only with the electrocardiogram in the prior art is solved, the measurement is simpler, and the accuracy is high.

Description

Method, device, system and storage medium for measuring pressure and ratio during non-waveform period Technical field

The present invention relates to the technical field of coronary artery medicine, and in particular to a method, a device, a coronary artery analysis system and a computer storage medium for measuring the pressure during the non-waveform period and the instantaneous non-waveform ratio.

Background technique

In recent years, due to the introduction of a new pressure-based index iFR for detecting the degree of coronary artery stenosis, the development of the field of coronary physiology has been promoted; by the distal pressure value obtained during the non-wave phase of the diastole, iFR measures the coronary The physiological effects of arterial stenosis on distal coronary arteries.

Real-time iFR pressure measurement combined with percutaneous coronary intervention (PCI) or coronary artery analysis system treatment heralds a new paradigm for functional disease assessment, using physiology to prove and guide the best coronary intervention therapy.

The ADVISE study found that during a certain period of time during the diastole (called wave-free period), the myocardium is in a state of maximum diastole, the effect of squeezing the blood vessels disappears, and the microvascular resistance in the coronary artery is relatively stable and the lowest It is similar to the average resistance achieved during coronary congestion made by vasodilators such as adenosine, achieving maximum blood perfusion.

In the prior art, it is necessary to use the ECG waveform and the pressure waveform curve to locate the waveform-free period. It can be seen that the electrocardiogram is a prerequisite for locating the waveform-free period in the prior art; however, when performing coronary artery functional measurements, it may not be possible to match the electrocardiogram with the pressure waveform due to the model of the equipment, which makes the two cannot be used together , Resulting in the inability to accurately locate the no-wave period, resulting in the inability to calculate the instantaneous average pressure of the no-wave period.

Summary of the invention

The present invention provides a method, device, coronary artery analysis system and computer storage medium for measuring the instantaneous average coronary pressure and the instantaneous non-waveform ratio in the non-waveform period, so as to solve the problem that the prior art cannot accurately locate the non-waveform period when the electrocardiogram is lacking. , The problem of not being able to calculate the instantaneous average pressure during the no-wave period.

In order to achieve the above objective, in the first aspect, the present application provides a method for measuring the instantaneous coronary artery average pressure during the non-waveform period, including:

Collect the patient's real-time blood pressure value;

Determine the non-wave phase of the patient's coronary artery;

According to the determined non-waveform period of the coronary artery of the patient, the blood pressure value of the non-waveform period is extracted, and the instantaneous average coronary pressure at the same time as the blood pressure value is calculated based on the blood pressure value.

Optionally, in the above-mentioned method for measuring the instantaneous coronary artery average pressure in the non-waveform period, the method for determining the non-waveform period of the patient's coronary artery includes: the invasive pressure waveform in one cardiac cycle, located in the diastolic phase. The invasive pressure waveform after trace to before the systole is the non-wave phase of the patient's coronary artery.

Optionally, in the above-mentioned method for measuring the instantaneous average coronary blood pressure in the waveform-free period, the collecting the real-time blood pressure value of the patient includes: collecting the real-time diastolic blood pressure of the patient.

Optionally, in the above-mentioned method for measuring the instantaneous coronary artery pressure in the non-waveform period, according to the blood pressure value, the formula for calculating the instantaneous coronary artery pressure at the same time as the blood pressure value is:

P _w =P _d +K;

Among them, P _w represents the instantaneous average coronary blood pressure during the non-waveform period, P _d represents the real-time diastolic blood pressure during the non-waveform period, and K is a constant between 5 and 20.

Optionally, in the above-mentioned method for measuring the instantaneous coronary artery average pressure in the non-waveform period, the K is a constant of 10-12.

Optionally, in the above-mentioned method for measuring the instantaneous average coronary blood pressure during the waveform-free period, the collecting the patient's real-time blood pressure value includes: collecting the patient's real-time diastolic blood pressure and real-time systolic blood pressure.

Optionally, in the above-mentioned method for measuring the instantaneous coronary artery average pressure in the non-waveform period, according to the blood pressure value, the formula for calculating the instantaneous coronary artery average pressure at the same time as the blood pressure value is:

P _w =P _d +(P _s -P _d )/n;

Among them, P _w represents the instantaneous average coronary blood pressure during the non-waveform period, P _d represents the real-time diastolic blood pressure during the non-waveform period, and P _s represents the patient's real-time systolic blood pressure during the non-waveform period, and n is a constant from 3 to 10.

Optionally, in the above-mentioned method for measuring the instantaneous average coronary blood pressure in the non-waveform period, the n is a constant of 6-8.

Optionally, in the above-mentioned method for measuring the instantaneous coronary artery average pressure in the non-waveform period, according to the blood pressure value, the formula for calculating the instantaneous coronary artery average pressure at the same time as the blood pressure value is:

P _m =(2×P _d +P _s )/3;

P _w =a×P _m ;

Among them, P _w represents the instantaneous average coronary pressure in the _{no-wave period, P m} represents the real-time average arterial pressure in the _{no-wave period, P d} represents the real-time diastolic blood pressure in the no-wave period, P _s represents the real-time systolic pressure in the no-wave period, a It is a constant between 0.5 and 1.5.

Optionally, in the above-mentioned method for measuring the instantaneous average coronary pressure in the non-waveform period, the a is a constant between 0.8 and 0.9.

In the second aspect, this application provides a method for measuring the instantaneous non-waveform ratio, including:

The above-mentioned method of measuring the instantaneous average coronary pressure during the non-waveform period;

According to the method of measuring the instantaneous coronary artery pressure in the non-waveform period, calculate the instantaneous coronary artery average pressure Pd _{w at the} distal end of the stenotic lesion in the non-waveform period and the instantaneous aortic average pressure Pa _{w in the} non-waveform period;

The mean coronary artery pressure on the instantaneous and average the instantaneous pressure Pd _w aorta Pa _w, calculated instantaneous waveform ratio iFR.

Optionally, in the foregoing method of measuring the instantaneous non-waveform ratio, if the non-waveform period is calculated to obtain N Pd _w and Pa _{w respectively} , then calculate the average value of the N instantaneous coronary artery average pressures Pd _w

And the average value of N instantaneous mean aortic pressure Pa _w

Based on average

with

Calculate the instantaneous non-waveform ratio iFR, the specific formula is:

In a third aspect, the present application provides a device for measuring the instantaneous coronary artery average pressure in the waveformless period, including: a waveformless identification unit, a blood pressure acquisition unit, and an instantaneous coronary artery average pressure measuring unit. Both the identification unit and the blood pressure acquisition unit are connected to the instantaneous coronary artery average pressure measurement unit;

The non-waveform identification unit is used to determine the non-waveform period of the patient's coronary artery;

The blood pressure collection unit is used to collect the blood pressure value of the patient;

The instantaneous coronary artery average pressure measuring unit is used to extract the blood pressure value of the non-waveform period in the blood pressure acquisition unit according to the determined non-waveform period of the coronary artery of the patient, and calculate the instantaneous value at the same time as the blood pressure value. Mean coronary artery pressure.

Optionally, in the above-mentioned apparatus for measuring instantaneous coronary artery average pressure in a waveform-free period, the blood pressure acquisition unit is a diastolic blood pressure acquisition module; the diastolic blood pressure acquisition module is used to acquire the patient's real-time diastolic blood pressure, and the instantaneous coronary artery The average pressure measurement unit _{calculates according to the formula P w} =P _d +K to obtain the instantaneous average coronary pressure P _w , where P _d represents the real-time diastolic blood pressure during the no-waveform period, and K is a constant between 5 and 20; or

The blood pressure acquisition unit includes a diastolic blood pressure acquisition module and a systolic blood pressure acquisition module. Both the diastolic blood pressure acquisition module and the systolic blood pressure acquisition module are connected to the instantaneous coronary artery average pressure measurement unit; the diastolic blood pressure acquisition module is used for The real-time diastolic blood pressure of the patient is collected, and the systolic blood pressure acquisition module is used to collect the real-time systolic blood pressure of the patient; the instantaneous coronary artery average pressure measuring unit calculates the instantaneous coronary artery average pressure P _w according to the following two formulas:

①P _w ＝P _d +(P _s -P _d )/n;

Among them, P _d represents the real-time diastolic blood pressure in the non-waveform period, P _s represents the patient's real-time systolic blood pressure in the non-waveform period, and n is a constant from 3 to 10;

②P _m =(2×P _d +P _s )/3;

P _w =a×P _m ;

Among them, P _d represents the real-time diastolic blood pressure in the no-wave period, P _s represents the real-time systolic pressure of the patient in the no-wave period, P _m represents the real-time average arterial pressure in the no-wave period, and a is a constant between 0.5 and 1.5.

In a fourth aspect, the present application provides a coronary artery analysis system, including: the above-mentioned device for measuring the instantaneous coronary artery average pressure in the non-waveform period.

In a fifth aspect, the present application provides a computer storage medium, and when the computer program is executed by a processor, the method for measuring the instantaneous average coronary blood pressure in the non-waveform period is realized.

The beneficial effects brought about by the solutions provided by the embodiments of the application include at least:

The present application provides a method for measuring the average pressure of coronary artery in the non-waveform period, without the need of electrocardiogram, only the invasive pressure waveform can be used to determine the non-waveform period, and the patient's real-time blood pressure value in the non-waveform period collected from clinical or other means; According to the determined non-waveform period of the patient’s coronary arteries, extract the blood pressure value in the non-waveform period, and calculate the instantaneous coronary artery average pressure in the non-waveform period at the same time as the blood pressure value based on the blood pressure value to solve the problem. There is a problem in the technology that the electrocardiogram must be relied on to measure the instantaneous average coronary pressure during the non-waveform period. The measurement is simpler and more accurate.

Description of the drawings

The drawings described here are used to provide a further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments and descriptions of the present invention are used to explain the present invention, and do not constitute an improper limitation of the present invention. In the attached picture:

FIG. 1 is a flowchart of a method for measuring instantaneous coronary artery average pressure in a waveform-free period of the present application;

Fig. 2 is a flow chart of the method for measuring instantaneous non-waveform ratio of the present application;

FIG. 3 is a structural block diagram of an embodiment of an apparatus for measuring instantaneous coronary artery average pressure in a waveform-free period according to the present application;

4 is a structural block diagram of another embodiment of an apparatus for measuring instantaneous coronary artery average pressure in a non-waveform period according to the present application;

Figure 5 is an invasive pressure waveform diagram;

The reference signs are described below:

No waveform identification unit 100, blood pressure acquisition unit 200, diastolic blood pressure acquisition module 210, systolic blood pressure acquisition module 220, and instantaneous coronary artery average pressure measurement unit 300.

detailed description

In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described clearly and completely below in conjunction with specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

Hereinafter, a number of embodiments of the present invention will be disclosed in the form of drawings. For clear description, many practical details will be described in the following description. However, it should be understood that these practical details should not be used to limit the present invention. In other words, in some embodiments of the present invention, these practical details are unnecessary. In addition, in order to simplify the drawings, some conventionally used structures and components will be shown in simple schematic ways in the drawings.

As shown in Fig. 1, the present application provides a method for measuring the instantaneous coronary artery average pressure during the non-waveform period, which includes:

S01, collecting the patient's real-time blood pressure value;

S02, determine the non-waveform period of the patient's coronary artery;

S03: Extract the blood pressure value in the non-waveform period according to the determined non-waveform period of the coronary artery of the patient, and calculate the instantaneous average coronary pressure at the same time as the blood pressure value based on the blood pressure value.

The present application provides a method for measuring the average pressure of coronary artery in the non-waveform period, without the need of electrocardiogram, only the invasive pressure waveform can be used to determine the non-waveform period, and the patient's real-time blood pressure value in the non-waveform period collected from clinical or other means; According to the determined non-waveform period of the patient’s coronary arteries, extract the blood pressure value in the non-waveform period, and calculate the instantaneous coronary artery average pressure in the non-waveform period at the same time as the blood pressure value based on the blood pressure value to solve the problem. There is a problem in the technology that the electrocardiogram must be relied on to measure the instantaneous average coronary pressure during the non-waveform period. The measurement is simpler and more accurate.

Example 1:

Step S01 includes: collecting the patient's real-time diastolic blood pressure;

Step S02 includes: the invasive pressure waveform within one cardiac cycle, and the invasive pressure waveform located after the diastolic fluctuation to before the systolic fluctuation is the non-waveform phase of the patient's coronary artery;

Step S03 includes: extracting the real-time diastolic blood pressure in the non-waveform period in S02 according to the non-waveform period of the patient's coronary artery determined in S01, and calculate the instantaneous average coronary pressure of the non-waveform period at the same time as the diastolic pressure according to the real-time diastolic blood pressure. The formula is:

P _w =P _d +K;

Wherein, P _w represents the instantaneous phase waveform without coronary artery mean pressure, P _d represents the waveform of the non-real-time diastolic blood pressure, K is a constant of 5 to 20; preferably, K is a constant 10 to 12.

Example 2:

Step S01 includes: collecting real-time diastolic blood pressure and real-time systolic blood pressure of the patient;

Step S02 includes: the invasive pressure waveform in a cardiac cycle, and the invasive pressure waveform located after the diastolic notch to before the systole is the non-wave phase of the patient's coronary artery;

Step S03 includes: according to the blood pressure value, the formula for calculating the instantaneous coronary artery average pressure in the non-waveform period at the same time as the blood pressure value is:

P _w =P _d +(P _s -P _d )/n;

Wherein, P _w represents the instantaneous average coronary pressure in the _{non-waveform period, P d} represents the real-time diastolic blood pressure in the non-waveform period, and P _s represents the patient's real-time systolic blood pressure during the non-waveform period, and n is a constant between 3 and 10; preferably, n It is a constant from 6 to 8.

Example 3:

Step S01 includes: collecting the patient's real-time blood pressure value includes: collecting the patient's real-time diastolic blood pressure and real-time systolic blood pressure;

Step S02 includes: the invasive pressure waveform in one cardiac cycle, and the invasive pressure waveform located after the diastolic dicrotic notch as shown in Fig. 5 from point C to point D before the systolic fluctuation is the non-waveform of the patient’s coronary artery period;

Step S03 includes: according to the blood pressure value, the formula for calculating the instantaneous coronary artery average pressure in the non-waveform period at the same time as the blood pressure value is:

P _m =(2×P _d +P _s )/3;

P _w =a×P _m ;

Among them, P _w represents the instantaneous average coronary pressure in the _{no-wave period, P m} represents the real-time average arterial pressure in the _{no-wave period, P d} represents the real-time diastolic blood pressure in the no-wave period, P _s represents the real-time systolic pressure in the no-wave period, a It is a constant between 0.5 and 1.5. Preferably, a is a constant of 0.8 to 0.9.

The following is a detailed description of this application in combination with specific implementation data:

_{This application extracts the diastolic pressure P d} , the systolic pressure P _{s and the P w} value measured by the guide wire from the clinic in the absence of waveform, as well as the mean arterial pressure P _m obtained by calculation, as well as the examples 1 and 2 _{P w} calculated from Example 3 is shown in Table 1, where K in Example 1 is 10, n in Example 2 is 6, and a in Example 3 is 0.9:

Table I

_{As can be seen from the above table, the instantaneous average coronary artery pressure P w} in the non-waveform period calculated in Example 1, Example 2 and Example 3 is basically the same as _{the P w} measured by the guide wire.

_{(1) Compare the P w} measured in Example 1 with the guide wire, and the difference is 1.4, 0.6, 0.2, 2.7, 0.1, 4.1, 1.2, 0.3 in order from small to large, and compare from the difference It can be seen that only two values exceed 2, remove the maximum value of 4.1 and the minimum value of 0.1 to calculate the average value of the difference, and the average value of the difference is 1.06. Therefore, the P _w measured in Example 1 is compared with the actual measured value of the guide wire. P _{w is} extremely close, and half of the total data obtained from the difference comparison is only about 0.5, which has high accuracy and high stability.

_{(2) Compare the P w} measured in Example 2 with the guide wire, in the order of from small to large, the difference is 1.2, 0.4, 1.0, 0.5, 2.7, 2.4, 3.1, 1.4, and compare from the difference It can be seen that only two values exceed 2, remove the maximum value of 3.1 and the minimum value of 0.4 to calculate the average value of the difference, and the average value of the difference is 1.53. Therefore, the P _w measured in Example 2 is compared with the actual measured value of the guide wire. P _{w is} extremely similar, and the calculated difference is relatively concentrated, with high stability and high accuracy, but the accuracy and stability of Example 2 are slightly lower than those of Example 1.

_{(3) Compare the P w} measured in Example 3 with the guide wire, in order from small to large, the difference is 6.6, 3.1, 0.1, 1.6, 6.1, 1.7, 6.1, 2.8, and compare from the difference It can be seen that removing the maximum value of 6.6 and the minimum value of 0.1 to calculate the average value of the difference, the average value of the difference is 3.56, so the P _{w measured in Example 3 is close to the actual P w} measured by the guide wire, but the calculated value The result is not as stable as Example 1 and Example 2, and the accuracy is high, but the accuracy of Example 3 is lower than that of Example 2.

_{In summary, the P w} measured in Example 1, Example 2 and Example 3 is compared with the real P _w measured by the guide wire, the results are very similar, the accuracy is high, and the stability is high. When the electrocardiogram and the pressure waveform are matched, when the two cannot be used together, it is impossible to accurately locate the non-waveform period, resulting in the problem that the instantaneous average pressure of the non-waveform period cannot be calculated; and the order of accuracy is: Example 1> Example 2 >Example 3; the order of stability is: Example 1>Example 2>Example 3.

As shown in Figure 2, this application provides a method for measuring the instantaneous non-waveform ratio, including:

S11, the above-mentioned method for measuring the instantaneous average coronary pressure during the non-waveform period;

S12: According to the method of measuring the instantaneous coronary artery pressure in the non-waveform period, calculate the instantaneous coronary artery average pressure Pd _{w at the} distal end of the stenotic lesion in the non-waveform period and the instantaneous aortic average pressure Pa _{w in the} non-waveform period;

S13: Calculate the instantaneous non-waveform ratio iFR according to the instantaneous average coronary pressure Pd _w and the instantaneous average aortic pressure Pa _w.

In an embodiment of the present application, S13 also includes: if N Pd _w and Pa _w are calculated separately during the no waveform period, then the average value of the N instantaneous coronary artery average pressure Pd _{w is calculated}

And the average value of N instantaneous mean aortic pressure Pa _w

Based on average

with

Calculate the instantaneous non-waveform ratio iFR, the specific formula is:

The following is a detailed description of iFR calculation data in combination with specific implementation data:

As shown in Figure 5, the invasive pressure waveform A represents the real-time change curve of the _{mean aortic pressure Pa w , the invasive pressure waveform B represents the real-time change curve of the coronary mean pressure Pd w} , and the straight line M is the distant stenosis lesion in the no-wave phase. The average value of N instantaneous coronary artery pressure Pd _{w at the end}

The ordinate of the point is the vertical line; therefore, the intersection point a of the straight line M and the invasive pressure waveform A is the average value of the pressure at the distal end of the stenotic lesion during the non-waveform period

The intersection point b of the straight line M and the invasive pressure waveform B is the average aortic pressure during the non-waveform period, that is, the average pressure at the proximal end of the stenotic lesion

Intersection a

Intersection b

iFR=82.5/89.7=0.92.

In summary, this application does not require an electrocardiogram. The wave-free period can be determined by the invasive pressure waveform, and then the iFR value can be obtained through the measurement of diastolic and systolic blood pressure. The measurement is simpler and due to the instantaneous average pressure in the wave-free period The measurement accuracy of iFR is high, so the measurement accuracy of iFR is high.

As shown in FIG. 3, the present application provides a device for measuring the instantaneous coronary artery average pressure in the non-waveform period, including: a waveformless identification unit 100, a blood pressure acquisition unit 200, and an instantaneous coronary artery average pressure measuring unit 300 The non-waveform identification unit 100 and the blood pressure acquisition unit 200 are both connected to the instantaneous coronary artery average pressure measurement unit 300; the non-waveform identification unit 100 is used to determine the non-waveform period of the patient’s coronary artery; the blood pressure acquisition unit 200 is used to collect the patient’s blood pressure value ; The instantaneous coronary artery average pressure measuring unit 300 is used to extract the blood pressure value of the waveformless period in the blood pressure acquisition unit 200 according to the determined non-waveform period of the patient’s coronary artery, and calculate the instantaneous coronary artery in the waveformless period at the same time as the blood pressure value. Mean pulse pressure.

In an embodiment of the present application, the blood pressure acquisition unit 200 is the diastolic blood pressure acquisition module 210 shown in FIG. 4; the diastolic blood pressure acquisition module 210 is used to acquire the patient's real-time diastolic blood pressure, and the instantaneous coronary artery average pressure measurement unit 300 is based on the formula P _w = P _d + K is calculated to obtain the instantaneous average coronary pressure P _w , where P _d represents the real-time diastolic blood pressure during the non-waveform period, and K is a constant between 5 and 20.

As shown in FIG. 4, in an embodiment of the present application, the blood pressure acquisition unit 200 includes a diastolic blood pressure acquisition module 210 and a systolic blood pressure acquisition module 220. The diastolic blood pressure acquisition module 210 and the systolic blood pressure acquisition module 220 are both related to the instantaneous coronary average pressure measurement. The unit 300 is connected; the diastolic blood pressure collection module 210 is used to collect the patient's real-time diastolic blood pressure, and the systolic blood pressure collection module 220 is used to collect the patient's real-time systolic blood pressure; the instantaneous coronary average pressure measurement unit 300 calculates the instantaneous coronary average according to the following two formulas Press P _w :

①P _w ＝P _d +(P _s -P _d )/n;

Among them, P _d represents the real-time diastolic blood pressure in the non-waveform period, P _s represents the patient's real-time systolic blood pressure in the non-waveform period, and n is a constant from 3 to 10;

②P _m =(2×P _d +P _s )/3;

P _w =a×P _m ;

Among them, P _d represents the real-time diastolic blood pressure in the no-wave period, P _s represents the real-time systolic pressure of the patient in the no-wave period, P _m represents the real-time average arterial pressure in the no-wave period, and a is a constant between 0.5 and 1.5.

The present application provides a coronary artery analysis system, including: the above-mentioned device for measuring the instantaneous coronary artery average pressure in the non-waveform period.

The present application provides a computer storage medium, and when a computer program is executed by a processor, the method for measuring the instantaneous average coronary blood pressure in the non-waveform period is realized.

Those skilled in the art know that various aspects of the present invention can be implemented as a system, a method, or a computer program product. Therefore, various aspects of the present invention can be specifically implemented in the following forms, namely: complete hardware implementation, complete software implementation (including firmware, resident software, microcode, etc.), or a combination of hardware and software implementations, Here can be collectively referred to as "circuit", "module" or "system". In addition, in some embodiments, various aspects of the present invention may also be implemented in the form of a computer program product in one or more computer-readable media, and the computer-readable medium contains computer-readable program code. The implementation of the method and/or system of the embodiments of the present invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.

For example, hardware for performing selected tasks according to an embodiment of the present invention may be implemented as a chip or a circuit. As software, selected tasks according to embodiments of the present invention can be implemented as a plurality of software instructions executed by a computer using any suitable operating system. In an exemplary embodiment of the present invention, one or more tasks according to the exemplary embodiment of the method and/or system as described herein are performed by a data processor, such as a computing platform for executing multiple instructions. Optionally, the data processor includes a volatile memory for storing instructions and/or data and/or a non-volatile memory for storing instructions and/or data, for example, a magnetic hard disk and/or Move the media. Optionally, a network connection is also provided. Optionally, a display and/or user input device such as a keyboard or mouse is also provided.

Any combination of one or more computer readable can be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium may be, for example, but not limited to, an electric, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the above. More specific examples (non-exhaustive list) of computer-readable storage media would include the following:

Electrical connection with one or more wires, portable computer disk, hard disk, random access memory (RAM), read only memory (ROM), erasable programmable read only memory (EPROM or flash memory), optical fiber, portable compact disk Read only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination of the above. In this document, the computer-readable storage medium can be any tangible medium that contains or stores a program, and the program can be used by or in combination with an instruction execution system, apparatus, or device.

The computer-readable signal medium may include a data signal propagated in baseband or as a part of a carrier wave, and computer-readable program code is carried therein. This propagated data signal can take many forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the foregoing. The computer-readable signal medium may also be any computer-readable medium other than the computer-readable storage medium. The computer-readable medium can send, propagate or transmit the program for use by or in combination with the instruction execution system, apparatus, or device .

The program code contained on the computer-readable medium can be transmitted by any suitable medium, including (but not limited to) wireless, wired, optical cable, RF, etc., or any suitable combination of the above.

For example, any combination of one or more programming languages can be used to write computer program codes for performing operations for various aspects of the present invention, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional process programming languages, such as "C" programming language or similar programming language. The program code can be executed entirely on the user's computer, partly on the user's computer, executed as an independent software package, partly on the user's computer and partly executed on a remote computer, or entirely executed on the remote computer or server. In the case of a remote computer, the remote computer can be connected to the user's computer through any kind of network including a local area network (LAN) or a wide area network (WAN), or it can be connected to an external computer (for example, using an Internet service provider to pass Internet connection).

It should be understood that each block of the flowcharts and/or block diagrams and combinations of blocks in the flowcharts and/or block diagrams can be implemented by computer program instructions. These computer program instructions can be provided to the processors of general-purpose computers, special-purpose computers, or other programmable data processing devices to produce a machine that makes these computer program instructions when executed by the processors of the computer or other programmable data processing devices , A device that implements the functions/actions specified in one or more blocks in the flowchart and/or block diagram is produced.

It is also possible to store these computer program instructions in a computer-readable medium. These instructions make computers, other programmable data processing devices, or other devices work in a specific manner, so that the instructions stored in the computer-readable medium generate An article of manufacture that implements instructions for the functions/actions specified in one or more blocks in the flowchart and/or block diagram.

Computer program instructions can also be loaded onto a computer (for example, a coronary artery analysis system) or other programmable data processing equipment to cause a series of operation steps to be performed on the computer, other programmable data processing equipment or other equipment to produce a computer-implemented process , Causing instructions executed on a computer, other programmable device, or other equipment to provide a process for implementing the functions/actions specified in the flowchart and/or one or more block diagrams.

The above specific examples of the present invention further describe the purpose, technical solutions and beneficial effects of the present invention in further detail. It should be understood that the above are only specific embodiments of the present invention and are not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (16)

1. A method for measuring the instantaneous average coronary blood pressure in the non-waveform period, which is characterized in that it comprises:

   Collect the patient's real-time blood pressure value;

   Determine the non-wave phase of the patient's coronary artery;

   According to the determined non-waveform period of the patient's coronary artery, the blood pressure value of the non-waveform period is extracted, and the instantaneous coronary artery average pressure at the same time as the blood pressure value is calculated based on the blood pressure value.
2. The method for measuring the instantaneous mean coronary artery pressure in the non-waveform period according to claim 1, wherein the method for determining the non-waveform period of the coronary arteries of a patient comprises:

   The invasive pressure waveform in a cardiac cycle, and the invasive pressure waveform located after the diastolic notch to before the systole in the diastolic phase is the non-wave phase of the patient's coronary artery.
3. The method for measuring the instantaneous average coronary pressure in the waveform-free period according to claim 1 or 2, wherein the collecting the patient's real-time blood pressure value comprises: collecting the patient's real-time diastolic blood pressure.
4. The method for measuring instantaneous coronary artery average pressure in a waveformless period according to claim 3, wherein the formula for calculating the instantaneous coronary artery average pressure at the same time as the blood pressure value according to the blood pressure value is :

   P _w =P _d +K;

   Among them, P _w represents the instantaneous average coronary blood pressure during the non-waveform period, P _d represents the real-time diastolic blood pressure during the non-waveform period, and K is a constant between 5 and 20.
5. The method for measuring the instantaneous average coronary pressure in the non-waveform period according to claim 4, wherein the K is a constant of 10-12.
6. The method for measuring the instantaneous average coronary blood pressure in the waveform-free period according to claim 1 or 2, wherein the collecting the patient's real-time blood pressure value comprises: collecting the patient's real-time diastolic blood pressure and real-time systolic blood pressure.
7. The method for measuring instantaneous coronary artery average pressure in a waveformless period according to claim 6, wherein the formula for calculating the instantaneous coronary artery average pressure at the same time as the blood pressure value according to the blood pressure value is :

   P _w =P _d +(P _s -P _d )/n;

   Among them, P _w represents the instantaneous average coronary blood pressure during the non-waveform period, P _d represents the real-time diastolic blood pressure during the non-waveform period, and P _s represents the patient's real-time systolic blood pressure during the non-waveform period, and n is a constant from 3 to 10.
8. 8. The method for measuring the instantaneous average coronary artery pressure in the non-waveform period according to claim 7, wherein the n is a constant of 6-8.
9. The method for measuring instantaneous coronary artery average pressure in a waveformless period according to claim 6, wherein the formula for calculating the instantaneous coronary artery average pressure at the same time as the blood pressure value according to the blood pressure value is :

   P _m =(2×P _d +P _s )/3;

   P _w =a×P _m ;

   Among them, P _w represents the instantaneous average coronary pressure in the _{no-wave period, P m} represents the real-time average arterial pressure in the _{no-wave period, P d} represents the real-time diastolic blood pressure in the no-wave period, P _s represents the real-time systolic pressure in the no-wave period, a It is a constant between 0.5 and 1.5.
10. The method for measuring the instantaneous average coronary artery pressure in the non-waveform period according to claim 9, wherein said a is a constant between 0.8 and 0.9.
11. A method for measuring instantaneous non-waveform ratio, characterized in that it includes:

    The method for measuring the instantaneous average coronary artery pressure in the non-waveform period according to any one of claims 1 to 10;

    According to the method of measuring the instantaneous coronary artery pressure in the non-waveform period, calculate the instantaneous coronary artery average pressure Pd _{w at the} distal end of the stenotic lesion in the non-waveform period and the instantaneous aortic average pressure Pa _{w in the} non-waveform period;

    The mean coronary artery pressure on the instantaneous and average the instantaneous pressure Pd _w aorta Pa _w, calculated instantaneous waveform ratio iFR.
12. The method for measuring the instantaneous non-waveform ratio according to claim 11, wherein if the non-waveform period is calculated to obtain N Pd _w and Pa _{w respectively} , then the average value of the N instantaneous coronary artery average pressures Pd _{w is calculated}

    

    And the average value of N instantaneous mean aortic pressure Pa _w

    

    Based on average

    

    with

    

    Calculate the instantaneous non-waveform ratio iFR, the specific formula is:

    
13. An apparatus for measuring instantaneous coronary artery average pressure in a waveformless period according to any one of claims 1 to 10, characterized in that it comprises: a waveformless identification unit, a blood pressure acquisition unit and an instantaneous coronary artery average pressure measuring unit , The non-waveform identification unit and the blood pressure acquisition unit are both connected to the instantaneous coronary artery average pressure measurement unit;

    The non-waveform identification unit is used to determine the non-waveform period of the patient's coronary artery;

    The blood pressure collection unit is used to collect the blood pressure value of the patient;

    The instantaneous coronary artery average pressure measuring unit is used to extract the blood pressure value of the non-waveform period in the blood pressure acquisition unit according to the determined non-waveform period of the coronary artery of the patient, and calculate the non-waveform period at the same time as the blood pressure value. The instantaneous mean coronary pressure during the waveform period.
14. The device for measuring instantaneous coronary artery average pressure in a waveform-free period according to claim 13, wherein the blood pressure acquisition unit is a diastolic blood pressure acquisition module; the diastolic blood pressure acquisition module is used to acquire the patient's real-time diastolic blood pressure, The instantaneous coronary artery average pressure measuring unit _{calculates according to the formula P w} =P _d +K to obtain the instantaneous coronary artery average pressure P _w , where P _d represents the real-time diastolic blood pressure during the waveform-free period, and K is a constant of 5-20; or

    The blood pressure acquisition unit includes a diastolic blood pressure acquisition module and a systolic blood pressure acquisition module. Both the diastolic blood pressure acquisition module and the systolic blood pressure acquisition module are connected to the instantaneous coronary artery average pressure measurement unit; the diastolic blood pressure acquisition module is used for The real-time diastolic blood pressure of the patient is collected, and the systolic blood pressure acquisition module is used to collect the real-time systolic blood pressure of the patient; the instantaneous coronary artery average pressure measuring unit calculates the instantaneous coronary artery average pressure P _w according to the following two formulas:

    ①P _w ＝P _d +(P _s -P _d )/n;

    Among them, P _d represents the real-time diastolic blood pressure in the non-waveform period, P _s represents the patient's real-time systolic blood pressure in the non-waveform period, and n is a constant from 3 to 10;

    ②P _m =(2×P _d +P _s )/3;

    P _w =a×P _m ;

    Among them, P _d represents the real-time diastolic blood pressure in the no-wave period, P _s represents the real-time systolic pressure of the patient in the no-wave period, P _m represents the real-time average arterial pressure in the no-wave period, and a is a constant between 0.5 and 1.5.
15. A coronary artery analysis system, characterized by comprising: the device for measuring instantaneous coronary artery average pressure in a waveformless period according to claim 13 or 14.
16. A computer storage medium, characterized in that, when a computer program is executed by a processor, the method for measuring instantaneous coronary artery average pressure in a waveformless period is implemented according to any one of claims 1 to 10.

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