WO2020221265A1 - Noninvasive human blood component concentration monitoring method and apparatus - Google Patents
Noninvasive human blood component concentration monitoring method and apparatus Download PDFInfo
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- WO2020221265A1 WO2020221265A1 PCT/CN2020/087618 CN2020087618W WO2020221265A1 WO 2020221265 A1 WO2020221265 A1 WO 2020221265A1 CN 2020087618 W CN2020087618 W CN 2020087618W WO 2020221265 A1 WO2020221265 A1 WO 2020221265A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
Definitions
- the invention belongs to the technical field of blood component concentration detection, and in particular relates to a method and equipment for non-invasive human blood component concentration monitoring.
- the invention aims to provide a simple and fast non-invasive monitoring method and equipment for the concentration of human blood components.
- the present invention provides the following technical solutions:
- the first method a method for monitoring the concentration of blood components in a non-invasive capillary artery, which sequentially includes the following steps:
- step (1) Repeat step (1) until the incident of n+1+m beams of different wavelengths of incident light is completed, and obtain the light intensity of n+1+m beams of incident light of different wavelengths through human organs at the peaks and valleys of the pulse;
- I ⁇ k,max , I ⁇ k,min are the light intensity of incident light with a wavelength of ⁇ k through human organs at the peak and trough of the pulse , respectively;
- ⁇ l is the blood thickness of the capillary blood flow entering the test light path between the peaks and troughs of the pulse;
- C i is the component concentration of component i in finger capillary blood, where i is 1 ⁇ n;
- ⁇ i, ⁇ k are the extinction coefficients of component i to incident light of wavelength ⁇ k , which are constants;
- Equation 1 concentration of n capillary blood components in Equation 1 and the thickness of blood entering the test light path between the capillary blood flow and the pulse wave peak and trough of the incident light.
- step (6) Compare whether the concentration of the n capillary blood components obtained in step (4) is within the normal range, if not, an alarm is issued.
- the method for displaying the concentration of n capillary blood components on the display screen is as follows: display the concentration of human blood components on the horizontal axis and the vertical axis; after step (6), return to step (1) for capillary artery Continuous monitoring of blood component concentration.
- the human organs include fingers, toes, and ears.
- the second type non-invasive monitoring method of human blood component concentration, including the following steps in sequence:
- T1 shoot incident light with a wavelength of ⁇ to the human organ, and collect the light intensity I ⁇ (t) of the incident light passing through the human organ at a certain time t;
- l(t) is the blood thickness of the human organ on the test light path at time t;
- C i is the component concentration of component i in human blood, with n components, where i is 1 ⁇ n;
- ⁇ i, ⁇ is the extinction coefficient of component i to incident light of wavelength ⁇ , which is a constant;
- D ⁇ (t) is the value of the logarithm of the light intensity of the components other than blood passing through the human organ on the test light path at time t; assume that D ⁇ (t) is a basically constant amount in a short time;
- step (T2) Repeat step (T1) quickly until the incident of n+1+m beams of incident light of different wavelengths is completed, the wavelength is ⁇ k, and the light intensity I ⁇ k of n+1+m beams of incident light of different wavelengths through human organs is obtained.
- K 1,2,...,n+1+m; m ⁇ 0;
- logI ⁇ 1 (t) ( ⁇ 1, ⁇ 1 C 1 + ⁇ 2, ⁇ 1 C 2 +...+ ⁇ n, ⁇ 1 C n )l(t)+D ⁇ 1 (t)
- logI ⁇ 2 (t) ( ⁇ 1, ⁇ 2 C 1 + ⁇ 2, ⁇ 2 C 2 +...+ ⁇ n, ⁇ 2 C n )l(t)+D ⁇ 2 (t)
- logI ⁇ n (t) ( ⁇ 1, ⁇ n C 1 + ⁇ 2, ⁇ n C 2 +...+ ⁇ n, ⁇ n C n )l(t)+D ⁇ n (t)
- logI ⁇ k (t) ( ⁇ 1, ⁇ k C 1 + ⁇ 2, ⁇ k C 2 +...+ ⁇ n, ⁇ k C n )l(t)+D ⁇ k (t)
- logI ⁇ n+1+m (t) ( ⁇ 1, ⁇ n+1+m C 1 + ⁇ 2, ⁇ n+1+m C 2 +...+ ⁇ n, ⁇ n+1+m C n )l( t)+D ⁇ n+1+m (t);
- the joint equations A has n+1+m equations, and there are n+1 unknowns, that is, l(t) and n Ci; since m ⁇ 0, the joint equations A can be solved by solving the joint equation A to obtain n individuals Blood component concentration Ci;
- step (T5) Display the concentration of n human blood components obtained in step (T4) on the display screen;
- the method of displaying the concentration of human blood components on the screen is as follows: display the concentration of human blood components on the horizontal axis and the vertical axis; after step (T6), return to step (T1) for human blood components Continuous monitoring of concentration.
- the solution in the step (T4) adopts the least square calculation method or neural network calculation method of pulse wave information.
- the human organs include fingers, toes, ears, and combinations thereof.
- the invention also discloses a monitoring device using the above monitoring method, which includes a light collection unit, a signal processing unit, a display unit, a wireless transmission unit and a user terminal.
- the light collection unit includes a multi-wavelength light source, a light intensity sensor, and a light source and The human organ containing cavity between the light intensity sensor.
- the light intensity sensor transmits the received light signal to the signal processing unit.
- the signal processing unit transmits the concentration signal of the human blood component to the display unit for display. At the same time, the signal processing unit will The concentration signal of human blood components is transmitted to the user terminal through the wireless transmission unit, and the user terminal can be a mobile phone or a computer.
- the human blood multi-component concentration such as blood oxygen, blood sugar, cholesterol, blood lipids, etc.
- the test method has high accuracy and can be realized Monitoring function.
- the device of the present invention can realize the monitoring of human blood component concentration, is convenient to use, convenient to carry, and has high monitoring accuracy.
- Figure 1 is a schematic diagram of the change of light intensity after incident light passes through human organs
- Figure 2 is a schematic diagram of a non-invasive human blood component concentration monitoring device
- Figure 3 is a schematic diagram of the structure of a non-invasive human blood component concentration monitoring device
- Figure 4 is a schematic diagram of the structure of a multi-wavelength light source
- Figure 5 is a schematic diagram of the light intensity sensor structure.
- the invention discloses a non-invasive monitoring method for the concentration of human blood components, which specifically includes the following steps:
- T1 shoot incident light with a wavelength of ⁇ to the human organ, and collect the light intensity I ⁇ (t) of the incident light passing through the human organ at a certain time t;
- l(t) is the blood thickness of the human organ on the test light path at time t;
- C i is the component concentration of component i in the human blood of the finger, with n components, where i is 1 ⁇ n;
- ⁇ i, ⁇ is the extinction coefficient of component i to incident light of wavelength ⁇ , which is a constant;
- D ⁇ (t) is the value of the logarithm of the light intensity of components other than blood (such as skin, tissue) passing through human organs on the test light path at time t; assume a short period of time (such as within a pulse cycle) , D ⁇ (t) is a basically constant quantity;
- step (T2) Repeat step (T1) quickly, until the incident light of n+1+m beams of different wavelengths is completed, the wavelength is ⁇ k, and the light intensity I ⁇ k of n+1+m beams of incident light of different wavelengths through human organs is obtained.
- K 1,2,...,n+1+m; m ⁇ 0;
- logI ⁇ 1 (t) ( ⁇ 1, ⁇ 1 C 1 + ⁇ 2, ⁇ 1 C 2 +...+ ⁇ n, ⁇ 1 C n )l(t)+D ⁇ 1 (t)
- logI ⁇ 2 (t) ( ⁇ 1, ⁇ 2 C 1 + ⁇ 2, ⁇ 2 C 2 +...+ ⁇ n, ⁇ 2 C n )l(t)+D ⁇ 2 (t)
- logI ⁇ n (t) ( ⁇ 1, ⁇ n C 1 + ⁇ 2, ⁇ n C 2 +...+ ⁇ n, ⁇ n C n )l(t)+D ⁇ n (t)
- logI ⁇ k (t) ( ⁇ 1, ⁇ k C 1 + ⁇ 2, ⁇ k C 2 +...+ ⁇ n, ⁇ k C n )l(t)+D ⁇ k (t)
- the joint equation system A has n+1+m equations and n+1 unknowns (n Ci, and l(t)). Therefore, as long as m ⁇ 0, the joint equations A can be solved to obtain n blood component concentrations Ci.
- the blood component concentration can be a value within a short period of time (or moment), or it can be an average value during a certain test period.
- step (T5) Display the concentration of n human blood components obtained in step (T4) on the display screen.
- the horizontal axis is the time and the vertical axis is the human blood component concentration.
- Embodiment 1 Using the least squares calculation method of pulse wave information, the joint equation group A is used to solve the embodiment of blood component concentration.
- the concentration of blood components can be obtained by the following least squares calculation method:
- I ⁇ k,max , I ⁇ k,min are the light intensity of incident light with a wavelength of ⁇ k through human organs at the peak and trough of the pulse , respectively;
- ⁇ l is the thickness of human blood entering the test light path between the peaks and troughs of the pulse
- the method of obtaining the extinction coefficient corresponding to human blood components is:
- step (2) (3 The data obtained in step (2) that can be expressed by formula A is processed into pulse period data, and substituted into formula 1, to obtain joint equations 2;
- I ⁇ k,max,j , I ⁇ k,min,j in the joint equation set 2 are the light intensity of incident light with a wavelength of ⁇ k through the human organ J at the peak and trough of the pulse , respectively,
- C i,j is the concentration of blood component i in the J-th human organ, and ⁇ lj is the blood thickness of the human blood flow into the test light path between the pulse wave peaks and troughs for the J-th human organ;
- step (1 the number of human blood components with different concentrations or the number of simulated human organs is at least the same as the number of human blood components that need to be obtained.
- step (1 the known concentration of human blood components is n+M human body organs or human body simulated organs.
- Human body organs in human blood include human body simulated organs.
- the known concentration of the human blood components in step (1 is in the human blood of multiple humans or multiple human simulated organs.
- this monitoring method includes the following steps in sequence:
- human organs include fingers, toes, and ears, and any one of fingers, toes, and ears may be selected.
- the human organs are fingers.
- the human organ in this embodiment may be a simulated human organ.
- V2 Quickly repeat step (V1) until the incident of n+1+m beams of incident light of different wavelengths is completed, and the light intensity of n+1+m beams of incident light of different wavelengths through human organs is obtained; where n is the same as the need to monitor
- the number of human blood components is related to the number of human blood components.
- the human blood components are blood sugar, cholesterol, and blood lipids, there are 3 human blood components that need to be monitored, n is 3 and m ⁇ 0.
- V4 The least squares calculation method is used to fit the component concentration C i of the component i in the finger human blood in the joint equation set 1 and the blood thickness of the human blood flow entering the test light path between the pulse peak and trough of the incident light, where , I is 1 ⁇ n.
- step (V5) Display the concentration of n human blood components obtained in step (V4) on the display screen.
- step (V4) can also be the continuous display of the concentration of n human blood components over a period of time.
- the realization method is: display the concentration of human blood components on the horizontal axis and the vertical axis.
- step (V6) return to step (V1) to continuously monitor the concentration of human blood components.
- the method for obtaining the extinction coefficient corresponding to the human blood component is:
- (U1 uses the existing standard blood drawing method to obtain the concentration of human blood components in human organs.
- the number of human organs is at least the same as the number of human blood components for which the concentration needs to be obtained.
- the existing invasive methods need to be used to obtain the concentration of blood glucose, cholesterol, and blood lipid of at least three human organs.
- the number of human organs is represented by 3+M, where M ⁇ 0.
- human organs include human body simulated organs.
- I ⁇ k, max, j, I ⁇ k, min, j are wavelength ⁇ k incident light intensity when the pulse peaks and troughs human organ through J, C i, j is the J-th individual
- concentration of the blood component i of the body organ or the simulated organ of the human body, ⁇ lj is the thickness of the blood flowing into the test light path between the pulse wave peak and the wave trough of the human blood flow for the J-th human organ.
- Embodiment 2 The following is an embodiment of solving the concentration of blood components through the neural network calculation method for the joint equation group A.
- F i (I ⁇ k (td), W) is the arithmetic function of the neural network, which represents a calculation method by adding a calculation weight table W to the input data I ⁇ k (td).
- Different neural networks (such as linear or nonlinear, single-layer or multi-layer, etc.) have different calculation methods.
- I ⁇ k (td) is the light intensity test data of n+1+m wavelengths collected in a time period t1 ⁇ t1+ ⁇ t of a fixed time interval ⁇ t and transmitted through a certain human organ.
- the total number is q (related to the time interval ⁇ t of collecting data and the rate of collecting data, and also related to the size of n, m).
- These data are the input data of neural computing network A;
- W is the coefficient or weight for calculating the input data I ⁇ k,j (td), and the total number is r.
- the r weights W in the neural network calculation model A can be obtained through the following training process:
- average i,j ((F i,j (I ⁇ k (td),W)-C i,j (t)) 2 ) is the actual concentration of n blood components tested in all ⁇ human organs
- the test value is the mean square error of the calculated value obtained by the neural network calculation model. argmin W, ⁇ t represents r W coefficients, and the selection of the time interval ⁇ t makes the above mean square error minimum.
- the method of the present invention realizes dynamic non-invasive monitoring of the concentration of human blood components, and can accurately obtain
- the user can use the instrument to compare the concentration of blood sugar, cholesterol, blood lipids, etc.
- the monitoring of related concentrations has important positive significance for the prevention of related diseases.
- the neural network algorithm uses the information at all times of the pulse wave to obtain the blood component concentration. Through the neural network algorithm, it is easy to process massive data, obtain useful information, and make the processed results more accurate. It is also possible to distinguish the difference in blood components between veins and arteries through neural network algorithms.
- Embodiment 3 The present invention also discloses a monitoring device using the above non-invasive human blood component concentration monitoring method, as shown in FIG. 2, including a light collection unit, a signal processing unit, a display unit, a wireless transmission unit and a user terminal.
- the light collection unit includes a multi-wavelength light source 3, one or more light intensity sensors 1, and a human organ accommodating cavity arranged between the light source and the light intensity sensor.
- the human organ accommodating cavity is used to accommodate human organs.
- the human organ is the finger 2.
- the multi-wavelength light source 3 is turned on sequentially, and the light intensity sensor 1 sequentially receives the light signals transmitted through the human organs, and transmits the received light signals to the signal processing unit, which transmits the concentration signals of human blood components to the display unit To display.
- the signal processing unit transmits the concentration signal of human blood components to the user terminal through the wireless transmission unit.
- the multi-wavelength light source 3 is at least a 3-wavelength light source, and one or more light intensity sensors 1.
- it is a 7-wavelength light source and a light intensity sensor.
- the opposite surfaces of the light source 3 and the light intensity sensor 1 are provided with a condenser lens 4 to facilitate the light transmittance of the light source to the sensor and improve the detection accuracy.
- the user terminal includes a mobile phone and a computer, and the user can select a mobile phone or a computer to view the concentration of human blood components.
- the multi-wavelength light source When in use, put human organs such as fingers, toes or ears between the multi-wavelength light source and the light intensity sensor.
- the multi-wavelength light source emits light signals in sequence, and the emitted light signals pass through the human organs such as fingers, toes or ears in sequence. Received by the light intensity sensor.
- the light intensity sensor converts it into light intensity, and transmits the light intensity to the signal processing unit.
- the signal processing unit processes and analyzes the received light intensity signal to calculate the concentration of human blood components.
- human blood components include blood sugar, cholesterol, and blood lipids.
- the signal processing unit transmits the obtained human blood component concentration to the display unit for display.
- the signal processing unit transmits the concentration signal of human blood components to the user terminal through the wireless transmission unit, and the user can view it through the user terminal.
- the device of the present invention can easily realize the non-invasive detection of the concentration of human blood multi-components, has little harm to the human body, has fast detection speed, high detection accuracy, and is convenient to carry.
- Embodiment 4 The present invention also discloses a method for monitoring the concentration of blood components in the non-invasive capillary arteries.
- the steps of this method are the same as those of the method in Embodiment 1. Both pulse peaks and troughs are used by the least square method. To obtain the concentration of blood components from the light intensity information of the point, you only need to modify the "human body” to "capillary artery", and the rest will not be repeated here.
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Abstract
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Claims (9)
- 无创毛细动脉血液组分浓度的监测方法,其特征在于:依次包括如下步骤:A method for monitoring the concentration of blood components in a non-invasive capillary artery is characterized in that it sequentially includes the following steps:(1)将入射光射向人体器官,分别采集入射光在脉搏波峰和波谷时透过人体器官的光强;(1) Shoot incident light to human organs, and collect the light intensity of the incident light passing through the human organs when the pulse wave peaks and troughs;(2)重复步骤(1),直至完成n+1+m束不同波长的入射光的入射,得到n+1+m束不同波长入射光在脉搏波峰和波谷时透过人体器官的光强;(2) Repeat step (1) until the incident of n+1+m beams of different wavelengths of incident light is completed, and obtain the light intensity of n+1+m beams of incident light of different wavelengths through human organs at the peaks and valleys of the pulse;(3)将步骤(2)得到的数据带入公式1,得到联合方程组1;(3) Bring the data obtained in step (2) into formula 1 to obtain joint equation set 1;其中,I λk,max,I λk,min分别为波长为λ k的入射光在脉搏波峰和波谷时透过人体器官 的光强; Among them, I λk,max , I λk,min are the light intensity of incident light with a wavelength of λ k through human organs at the peak and trough of the pulse , respectively;Δl为毛细动脉血流在脉搏的波峰和波谷间进入测试光路的血液厚度;Δl is the blood thickness of the capillary blood flow entering the test light path between the peaks and troughs of the pulse;C i为手指毛细动脉血液内组分i的成分浓度,其中,i为1~n; C i is the component concentration of component i in finger capillary blood, where i is 1~n;ε i,λk为组分i对波长为λ k的入射光的消光系数,其为常数; ε i, λk are the extinction coefficients of component i to incident light of wavelength λ k , which are constants;(4)用最小二乘法拟合得到方程组1中的n个毛细动脉血液组分的浓度与毛细动脉血流在入射光的脉搏波峰和波谷间进入测试光路的血液厚度。(4) Use the least squares method to fit the concentration of n capillary blood components in Equation 1 and the thickness of blood entering the test light path between the capillary blood flow and the pulse wave peak and trough of the incident light.(5)将步骤(4)中获取的n个毛细动脉血液组分浓度在显示屏上进行显示;(5) Display the concentration of n capillary blood components obtained in step (4) on the display screen;(6)比对步骤(4)中获取的n个毛细动脉血液组分浓度是否在正常范围内,如否,则报警。(6) Compare whether the concentration of the n capillary blood components obtained in step (4) is within the normal range, if not, an alarm is issued.
- 如权利要求1所述的无创毛细动脉血液组分浓度的监测方法,其特征在于:n个毛细动脉血液组分浓度在显示屏上进行显示的方法为:以横轴为时间,纵轴为人体血液组分浓度进行显示;在步骤(6)之后,返回步骤(1)进行毛细动脉血液组分浓度的连续监测。The method of non-invasive capillary blood component concentration monitoring according to claim 1, wherein the method for displaying the concentration of n capillary blood components on the display screen is: taking the horizontal axis as time and the vertical axis as human body The blood component concentration is displayed; after step (6), return to step (1) for continuous monitoring of the capillary blood component concentration.
- 如权利要求2所述的无创毛细动脉血液组分浓度的监测方法,其特征在于:所述人体器官包括手指、脚趾、耳朵。The method for monitoring the concentration of non-invasive capillary blood components according to claim 2, wherein the human organs include fingers, toes, and ears.
- 无创人体血液组分浓度的监测方法,其特征在于:依次包括如下步骤:The non-invasive monitoring method of human blood component concentration is characterized in that it includes the following steps in sequence:(T1)、将某一波长为λ的入射光射向人体器官,采集某一时刻t时入射光透过人体器官的光强Iλ(t);(T1), shoot incident light with a wavelength of λ to the human organ, and collect the light intensity Iλ(t) of the incident light passing through the human organ at a certain time t;log I λ(t)=(ε 1,λC 1+ε 2,λC 2+...+ε n,λC n)l(t)+D λ(t) 公式A log I λ (t)=(ε 1,λ C 1 +ε 2,λ C 2 +...+ε n,λ C n )l(t)+D λ (t) Formula A其中,l(t)为时刻t时在测试光路上的人体器官的血液厚度;Among them, l(t) is the blood thickness of the human organ on the test light path at time t;C i为人体血液内组分i的成分浓度,设有n个组分,其中,i为1~n; C i is the component concentration of component i in human blood, with n components, where i is 1~n;ε i,λ为组分i对波长为λ的入射光的消光系数,其为常数; ε i,λ is the extinction coefficient of component i to incident light of wavelength λ, which is a constant;Dλ(t)为时刻t时透过测试光路上的人体器官的血液以外组分的光强的取 对数后的值;假定一个短时间内Dλ(t)是基本不变的量;Dλ(t) is the value of the logarithm of the light intensity of components other than blood passing through the human organ on the test light path at time t; assume that Dλ(t) is a basically constant amount in a short time;(T2)、快速重复步骤(T1),直至完成n+1+m束不同波长的入射光的入射,波长为λk,得到n+1+m束不同波长入射光透过人体器官的光强Iλk,k=1,2,…,n+1+m;m≥0;(T2). Repeat step (T1) quickly, until the incident light of n+1+m beams of different wavelengths is completed, the wavelength is λk, and the light intensity Iλk of n+1+m beams of incident light of different wavelengths through human organs is obtained. , K=1,2,...,n+1+m; m≥0;(T3)、重复步骤(T1)和(T2),得到一段时间的透过人体器官的光强,用以下联合方程组A表示这一段时间的光强:(T3) Repeat steps (T1) and (T2) to obtain the light intensity passing through human organs for a period of time. Use the following joint equation A to express the light intensity during this period of time:log I λ1(t)=(ε 1,λ1C 1+ε 2,λ1C 2+...+ε n,λ1C n)l(t)+D λ1(t) log I λ1 (t)=(ε 1,λ1 C 1 +ε 2,λ1 C 2 +...+ε n,λ1 C n )l(t)+D λ1 (t)log I λ2(t)=(ε 1,λ2C 1+ε 2,λ2C 2+...+ε n,λ2C n)l(t)+D λ2(t) log I λ2 (t)=(ε 1,λ2 C 1 +ε 2,λ2 C 2 +...+ε n,λ2 C n )l(t)+D λ2 (t)……log I λn(t)=(ε 1,λnC 1+ε 2,λnC 2+...+ε n,λnC n)l(t)+D λn(t) log I λn (t)=(ε 1,λn C 1 +ε 2,λn C 2 +...+ε n,λn C n )l(t)+D λn (t)……log I λk(t)=(ε 1,λkC 1+ε 2,λkC 2+...+ε n,λkC n)l(t)+D λk(t) log I λk (t)=(ε 1,λk C 1 +ε 2,λk C 2 +...+ε n,λk C n )l(t)+D λk (t)……log I λn+1+m(t)=(ε 1,λn+1+mC 1+ε 2,λn+1+mC 2+...+ε n,λn+1+mC n)l(t)+D λn+1+m(t)(T4)联合方程组A有n+1+m个方程,有n+1个未知数,即l(t)与n个Ci;由于m≥0,则通过求解联合方程组A即得n个人体血液成分浓度Ci; log I λn+1+m (t)=(ε 1,λn+1+m C 1 +ε 2,λn+1+m C 2 +...+ε n,λn+1+m C n )l (t)+D λn+1+m (t)(T4) The joint equations A has n+1+m equations and n+1 unknowns, namely l(t) and n Ci; because m≥0 , Then by solving the joint equations A, the concentration of n individual blood components Ci is obtained;(T5)将步骤(T4)中获取的n个人体血液组分浓度在显示屏上进行显示;(T5) Display the concentration of n human blood components obtained in step (T4) on the display screen;(T6)比对步骤(T4)中获取的n个人体血液组分浓度是否在正常范围内,如否,则报警。(T6) Whether the concentration of n human blood components obtained in the comparison step (T4) is within the normal range, if not, an alarm is issued.
- 如权利要求4所述的无创人体血液组分浓度的监测方法,其特征在于:n个人体血液组分浓度在显示屏上进行显示的方法为:以横轴为时间,纵轴为人体血液组分浓度进行显示;步骤(T6)之后,返回步骤(T1)进行人体血液组分浓度的连续监测。The method for monitoring the concentration of non-invasive human blood components according to claim 4, wherein the method for displaying the concentration of human blood components on the display screen is: taking the horizontal axis as the time and the vertical axis as the human blood group After the step (T6), return to step (T1) for continuous monitoring of the concentration of human blood components.
- 如权利要求5所述的无创人体血液组分浓度的监测方法,其特征在于:所述的步骤(T4)中的求解采用的是脉搏波信息的最小二乘计算法。The method for monitoring the concentration of non-invasive human blood components according to claim 5, wherein the solution in the step (T4) adopts the least square calculation method of pulse wave information.
- 如权利要求5所述的无创人体血液组分浓度的监测方法,其特征在于:所述的步骤(T4)中的求解采用的是神经网络计算法。The method for monitoring the concentration of non-invasive human blood components according to claim 5, characterized in that the solution in the step (T4) adopts a neural network calculation method.
- 如权利要求4-7任意一项所述的无创人体血液组分浓度的监测方法,其特征在于:人体器官包括手指、脚趾、耳朵以及它们的组合。The method for monitoring the concentration of non-invasive human blood components according to any one of claims 4-7, wherein the human organs include fingers, toes, ears, and combinations thereof.
- 利用权利要求1或4所述的监测方法的监测设备,其特征在于:包括光采集单元,信号处理单元、显示单元、无线传输单元以及用户端,光采集单元包括多波长光源、光强传感器以及设置于光源和光强传感器之间的人体器官容纳腔,光强传感器将接收到的光信号传输到信号处理单元,信号处理单元将人体血液组分的浓度信号传输到显示单元进行显示,同时,信号处理单元将人体血液组分的浓度信号通过无线传输单元传输到用户端。The monitoring device using the monitoring method of claim 1 or 4, characterized in that it comprises a light collection unit, a signal processing unit, a display unit, a wireless transmission unit and a user terminal, and the light collection unit comprises a multi-wavelength light source, a light intensity sensor, and The human organ accommodating cavity is arranged between the light source and the light intensity sensor. The light intensity sensor transmits the received light signal to the signal processing unit. The signal processing unit transmits the human blood component concentration signal to the display unit for display. At the same time, The signal processing unit transmits the concentration signal of the human blood component to the user terminal through the wireless transmission unit.
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