WO2020199605A1 - Parathyroid gland recognition device and system - Google Patents
Parathyroid gland recognition device and system Download PDFInfo
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- WO2020199605A1 WO2020199605A1 PCT/CN2019/119012 CN2019119012W WO2020199605A1 WO 2020199605 A1 WO2020199605 A1 WO 2020199605A1 CN 2019119012 W CN2019119012 W CN 2019119012W WO 2020199605 A1 WO2020199605 A1 WO 2020199605A1
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- light source
- autofluorescence
- parathyroid
- light
- excitation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4227—Evaluating particular parts, e.g. particular organs endocrine glands, i.e. thyroid, adrenals, hypothalamic, pituitary
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
Definitions
- the invention relates to a device and a system for identifying parathyroid glands, and belongs to the technical field of biological tissue detection and identification.
- hypoparathyroidism is an important complication of thyroidectomy. It has been reported that after total thyroidectomy, the incidence of temporary hypoparathyroidism is 20% to 60%, and the incidence of permanent hypoparathyroidism is 1% to 7%. Therefore, the incidence of parathyroid glands during surgery Effective preservation is particularly important. Accurate identification of parathyroid glands during surgery is a prerequisite for effective parathyroid gland preservation.
- parathyroid glands have the following characteristics: 1) tiny: the size is about a few millimeters, which is extremely difficult to detect with the naked eye; 2) difficult to distinguish: difficult to distinguish from normal tissues such as fat granules; 3) variable number: thyroid The number of parathyroid glands is generally 3-5. According to literature reports, about 48% to 62% of Chinese have 4; 4) Unfixed location: The location of parathyroid glands varies from person to person; 5) It can be planted within a specific time.
- Intraoperative visual recognition visual recognition by naked eyes or with the help of endoscopy;
- Dyeing recognition Mark the parathyroid glands with methylene blue (MB), nano carbon, and indocyanine green (ICG), and then identify them with the help of cavity mirrors and optical instruments.
- MB methylene blue
- ICG indocyanine green
- parathyroid glands have autofluorescence properties in the near infrared region. When it is illuminated with a wavelength of 785nm, the parathyroid glands can produce near-infrared autofluorescence with a wavelength of 820nm.
- Ladurner et al. reported that by exposing the parathyroid glands and surrounding tissues to near-infrared light of 690-770nm, the parathyroid tissues will show near-infrared autofluorescence.
- the recognition penetration depth is about 2mm, and the recognition in the operation requires the help of the doctor's superb peeling technique to be applied. Therefore, one of the technical problems to be solved by the present invention is to increase the recognition penetration depth of the device.
- the Chinese invention patent with application publication number CN107361744A provides a parathyroid gland identification device and method, which uses a light source laser diode with a power of milliwatts (between 80-100mW, paragraphs 0062, 0080 of the specification).
- the power of the light source in the prior art is in the milliwatt level, and its shortcoming is that the probe is at the micron level (about 50-500 microns), and its emitted identification spot area is small (the spot area and the parathyroid gland) The size is equivalent), similar to a point light source.
- Autofluorescence recognition of parathyroid glands needs to compare the intensities of several types of autofluorescence such as parathyroid, thyroid and other tissues (such as muscle and fat). Because the recognition spot in the prior art is too small (or even smaller than the recognition spot) The area of the parathyroid gland) is often unable to be identified by the comparison of the fluorescence intensity of the font.
- the area of the identification spot in the prior art is too small compared with the entire surgical field. Therefore, it is difficult to identify the parathyroid gland in the device of the prior art. Therefore, the second technical problem to be solved by the present invention is: under the premise of not burning the exposed tissues of the human body, a surface light source is used to realize large-scale and large-area recognition, improve the recognition accuracy, and shorten the recognition time.
- the third problem to be solved by the present invention is to provide a spectroscopic imager, which can quickly scan and recognize the excised human tissue, and if it is found that the parathyroid gland has been miscut, it can be identified and located in time and retrieved for planting.
- the fourth problem to be solved by the present invention is: by identifying the blood supply of the parathyroid glands, it is judged whether the parathyroid glands are temporary or permanent hypoparathyroidism. If the blood supply of the parathyroid glands in the body is disconnected, the operation Before closing the mouth, replant the parathyroid glands.
- One of the objectives of the present invention is to provide a parathyroid gland recognition system, which aims to quickly and accurately identify the parathyroid glands through the cooperation of multiple recognition devices, and to minimize the incidence of permanent hypoparathyroidism.
- the second object of the present invention is to provide a parathyroid gland recognition device, which is used in each link of surgery, and has a large recognition range, fast speed and accuracy.
- the third purpose of the present invention is to identify and locate the parathyroid glands that may be mistakenly cut within the time when the parathyroid glands can be planted, and plant them in time to reduce the incidence of permanent hypoparathyroidism to less than 1%.
- a parathyroid gland recognition device comprising
- Autofluorescence excitation device used to generate 650-810nm excitation light, irradiate human tissues, and make parathyroid glands produce autofluorescence;
- Autofluorescence acquisition and processing device collects parathyroid autofluorescence, and processes it into identifiable information
- the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, so as to avoid interference with the identification of the parathyroid gland.
- the fluorescence characteristics of the parathyroid glands 1) The wavelength of the excitation light is between 650-810nm to excite the parathyroid glands to produce fluorescence; 2) The intensity of the excitation light must reach the threshold to excite the parathyroid glands Fluorescence is produced; 3) The autofluorescence is very weak and will inevitably be affected by the stray light of the excitation light source itself and cannot be identified.
- the prior art recognition device is not provided with an excitation light filter device, which is an important factor that makes the prior art solution difficult to form a commercial device that can be used for surgery.
- the light power per unit area of the excitation light is 20-150000 mw/cm 2 .
- the light power per unit area of the excitation light is 20-100 mW/cm 2 , and the spot area formed by the excitation light is 50-200 cm 2 . This condition is particularly suitable for handheld identification devices.
- the light power per unit area of the excitation light is 100-15000 mW/cm 2 , and the spot area formed by the excitation light is 0.1-1 cm 2 . This condition is particularly suitable for laser probe type identification devices.
- the maximum value of the excitation light intensity should be lower than the maximum threshold that can cause discomfort or burns to the exposed tissue of the patient, and less than the minimum threshold that can excite the parathyroid glands to produce autofluorescence.
- the applicant has shown through more than 500 clinical trials that the present invention selects a small range of light power per unit area (20-15000mw/cm 2 ). After selecting this range, it can clearly and sharply display/identify the parathyroid glands, with the greatest possible reduction Probability of clinical misjudgment.
- the light source is one or a combination of any of a laser, an LED, a xenon lamp, and a halogen lamp.
- a laser an LED
- a xenon lamp a xenon lamp
- a halogen lamp a laser that can be integrated to form a light source
- the light source is one or more lasers, and the power of the single laser is W class (watt class).
- the laser is a structured light laser (VCSEL), which can achieve a single power of watts, making the equipment more convenient and miniaturized.
- VCSEL structured light laser
- Another outstanding advantage of the structured light laser is that the spot is uniform.
- the first type of identification device is a first type of identification device
- the first type of identification device of the present invention is to provide a parathyroid gland identification device, which is used during surgery to directly illuminate the wound surface.
- the light spot generated by the light source basically covers the entire wound surface.
- the first type identification device can identify most of the parathyroid glands. gland.
- a parathyroid gland recognition device comprising
- the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;
- Autofluorescence acquisition and processing device which collects parathyroid autofluorescence and processes it into identifiable information
- a light filtering device the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, and avoiding interference with the identification of the parathyroid gland;
- the autofluorescence acquisition and processing device is an infrared camera, which images the wound surface, and the bright spot is the parathyroid gland; the area of the excitation light spot basically covers the surgical wound surface.
- “basic coverage” means that the spot area is equivalent to or larger than the surgical wound area.
- the first solution of the autofluorescence excitation device is to include a built-in independent light source which is formed by arranging a plurality of lasers.
- the infrared camera includes a lens, and a plurality of lasers and the lens are basically arranged on the same plane.
- the plurality of lasers are arranged in a ring, a concentric circle, or a square arrangement. It should be considered that the arrangement that enables independent light sources to emit uniform light intensity falls within the protection scope of the present invention.
- a heat dissipation device can be provided according to the prior art.
- the second solution of the autofluorescence excitation device is to include an external light source, which is directly or indirectly connected to a single quartz optical fiber, and the other end of the quartz optical fiber is connected to a lens, so that the point-like light becomes the surface-like light.
- the external light source can be one laser or multiple lasers coupled.
- the autofluorescence excitation device includes an external light source
- the external light source includes multiple lasers
- each laser is directly or indirectly connected to multiple quartz optical fibers
- the other ends of the multiple optical fibers are bundled or connected to a lens.
- the autofluorescence excitation device includes an external light source, and the external light source is directly or indirectly connected to a plastic optical fiber, and the plastic optical fiber has a diameter greater than 2 mm.
- the application scenario of the above scheme is: the first type of identification device is to directly irradiate the wound.
- Another light source setting method of the first type of identification device is to illuminate from the back of the wound.
- the specific plan is:
- the autofluorescence excitation device includes a circular light source to illuminate the back of the wound. This solution can also form a surface light source in the visual field.
- the autofluorescence excitation device includes a mobile light source to illuminate the back of the wound.
- the second type of identification device is the second type of identification device.
- the second type of identification device of the present invention is: when the first type of device fails to detect four parathyroid glands, it uses close-range irradiation or probes to further identify the parathyroid glands.
- the penetration distance of the excitation light of the second type of identification device is several times that of the first type of device.
- the specific technical scheme adopted by the second type of identification device is:
- a parathyroid gland recognition device comprising
- the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;
- Autofluorescence acquisition and processing device which collects parathyroid autofluorescence and processes it into identifiable information
- a light filtering device the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, and avoiding interference with the identification of the parathyroid gland;
- the autofluorescence excitation device includes a light source
- the laser probe also includes a laser probe.
- the laser probe is equipped with optical fibers.
- One of the optical fibers is connected to a light source, called a luminescent fiber.
- the light power per unit area of the excitation light is 100-15000 mw/cm 2 , and the light spot formed by the excitation light The area is 0.1-1cm 2 .
- the maximum burial depth of parathyroid glands is 6mm. It has been verified that the above-mentioned solution of the present invention is characterized by a detection depth of up to 6mm, which is sufficient to meet the surgical requirements. At the same time, the detection depth is the number of the prior art. Times.
- the autofluorescence collection and processing device includes an external camera to illuminate the wound, collect the parathyroid autofluorescence, and process it into recognizable image information.
- the autofluorescence collection and processing device further includes a spectrum analysis device, and the laser probe is provided with two optical fibers, one of which is connected to the light source, called a light-emitting fiber, and the other is connected to a spectrum analysis device, called For daylighting fiber.
- the spectrum analysis device is one of a spectrometer, a photomultiplier tube or an APD photodetector; the spectrum analysis device transmits back autofluorescence through a light collecting fiber and analyzes the wavelength and intensity value of the special spectrum of the parathyroid gland to determine The location of the parathyroid glands.
- the autofluorescence collection and processing device also includes an alarm device, when the spectral analysis device determines the position of the parathyroid gland, an alarm message is issued to remind the doctor.
- the laser probe includes a hand-held part, and the hand-held part also includes a camera, and the camera is connected to an image display device, such as a computer, a mobile phone, and other image display devices.
- the solution is to miniaturize the external camera and install it on the laser probe.
- the autofluorescence collection and processing device includes a laser generating mechanism, a transmission mechanism and a laser probe
- the laser generating device includes several lasers, a power supply module for powering the lasers, a control module for controlling the power supply module, and The first wireless module, the control module is wirelessly connected to the laser probe through the first communication module, the laser generating mechanism is connected to the laser probe through a transmission mechanism;
- the transmission mechanism includes an optical fiber, one end of the optical fiber is connected to the laser, and the other end Connected to the laser probe;
- the laser probe includes a collimator, a control panel, and a second communication module, the collimator is connected to the transmission mechanism, the second communication module is wirelessly connected to the first communication module, the control panel Wirelessly connect with the control module through the second communication module;
- a filter is also provided between the laser and the optical fiber;
- the wavelength emitted by the laser is 785nm and the power is 1.5W;
- the number of the lasers is 4;
- the optical fiber is pmma plastic optical fiber.
- a parathyroid gland recognition device comprising
- the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;
- Autofluorescence acquisition and processing device which collects parathyroid autofluorescence and processes it into identifiable information
- a light filtering device the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, and avoiding interference with the identification of the parathyroid gland;
- the light power per unit area of the excitation light is 100-15000 mW/cm 2
- the spot area formed by the excitation light is 0.1-1 cm 2 .
- the autofluorescence excitation device, the autofluorescence acquisition and processing device, and the filter device are integrated in the housing, wherein the autofluorescence acquisition and processing device includes a camera, the camera includes a lens, and the lens is integrated with the autofluorescence excitation device.
- the autofluorescence excitation device includes a built-in light source
- the built-in light source includes multiple lasers
- the multiple lasers are integrated with a lens.
- the hand-held detection device can be set as an external light source.
- the first solution is: the autofluorescence excitation device includes an external light source, the external light source is directly or indirectly connected to a single quartz optical fiber, and the other end of the quartz optical fiber is connected The lens turns the spot light into a surface light.
- the external light source can be one laser or multiple lasers coupled.
- the autofluorescence excitation device includes an external light source, the external light source includes multiple lasers, and each laser is directly or indirectly connected to multiple quartz optical fibers, and the other ends of the multiple optical fibers are bundled or connected Lens.
- the third solution is that the autofluorescence excitation device includes an external light source, and the external light source is directly or indirectly connected to a plastic optical fiber, the diameter of the plastic optical fiber is greater than 2 mm.
- a parathyroid gland recognition device comprising a housing, the front end of the housing is a detection end, the back end is a gripping end, the detection end is provided with an infrared fluorescence excitation mechanism for stimulating autofluorescence of the human body, and the housing is provided with A light source collection mechanism and a circuit board for collecting autofluorescence of the human body and generating an image.
- the light source collection mechanism includes a camera arranged inside the housing and a lens arranged at the detection end and connected to the camera.
- the circuit board is connected to the infrared fluorescence excitation mechanism and The light source collection mechanism is connected by wires.
- the circuit board includes a control module, a communication module, and a power supply module. The modules are connected by wires.
- the control module is used to control the infrared fluorescence excitation mechanism, the light source collection mechanism and each module. ;
- the communication module is connected to a computer through a wireless signal, and is used to transmit the image generated by the light source collection mechanism to the computer, and is used to control the light source collection mechanism through the computer;
- the power module is used to supply power to the infrared fluorescence excitation mechanism, the light source collection mechanism, and each module; preferably, the infrared fluorescence excitation mechanism includes a lamp panel arranged at the front end of the housing, and a lens through hole is provided in the middle of the lamp panel , The front end of the lamp panel is provided with a focusing lens in parallel, and a number of infrared emission tubes are arranged on the surface of the lamp panel between the focusing lens and the lamp panel around the lens through hole;
- the lens is arranged in the lens through hole
- the camera includes a photosensitive element, a filter mechanism is provided in front of the photosensitive element, and the filter mechanism includes a gear wheel, a motor gear, and a motor.
- the center of the gear wheel is provided with a rotating shaft, the gear wheel and the motor gear Mutual meshing, the motor gear shaft is connected with the motor output shaft, the motor drives the motor gear to rotate, thereby driving the meshing gear wheel to rotate along the rotating shaft.
- the gear wheel is provided with several filter through holes around the rotating shaft, and the turntable rotates to the corresponding In the position, the through hole of the filter is aligned with the position of the photosensitive element, and there is a filter in the through hole of the filter;
- the material of the lamp panel is aluminum
- the infrared emitting tubes are arranged in a circular array, and the number is 20-100;
- control module is a single-chip microcomputer
- the filter has two through holes, and the two filter through holes are respectively provided with a filter A with a light transmission band of 810-1000 nm and a filter B with a light transmission band of 700-1000 nm;
- the cut-off depths of filter A and filter B are both OD4-OD6;
- an adjustment switch is provided on the housing, the adjustment switch is connected to the circuit board through a line, the grip end is provided with an ergonomic grip, and a battery compartment is arranged inside the grip, and the battery compartment passes through the circuit Connect with the power supply module.
- the third type of identification device is the third type of identification device.
- the application scenario of the third type of identification device of the present invention is to check whether the parathyroid gland is damaged after thyroidectomy.
- the fluorescent drug methylene blue or ICG
- the fluorescence emitted by the methylene blue or ICG is detected by a laser probe or a handheld identification device to determine whether the drug has entered the parathyroid gland, that is, the blood of the parathyroid gland. Whether it was injured during the operation.
- the structure of this type of identification device is basically the same as that of the handheld identification device.
- the clinical significance of the third type of identification device is: for the parathyroid glands with good blood supply, they will definitely survive, and the doctor can safely close the wound; for the parathyroid glands with poor blood supply, transplantation can be considered, which is planted in the blood supply. Good location to keep it alive.
- the fourth type of identification device is the fourth type of identification device.
- the parathyroid glands were inevitably cut by mistake during the operation.
- the parathyroid glands can be retrieved and planted during the planting period.
- the fourth type of identification device of the present invention is called "area imaging fluorescence spectrum analyzer" or “matrix fluorescence spectrum analyzer”. It is different from the traditional point-type fluorescence spectrum analyzer and is changed from the traditional one-dimensional analysis. For two-dimensional analysis, the recognition speed of specimens is significantly improved to adapt to the short time window of parathyroid implantation (usually within 15 minutes).
- the specific technical scheme adopted by the fourth type of identification device is:
- a parathyroid gland recognition device comprising
- the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;
- Autofluorescence acquisition and processing device which collects parathyroid autofluorescence and processes it into identifiable information
- the autofluorescence excitation device includes a light source, and the light source is an LED light source, a semiconductor point laser, a laser or a vcsel uniform field intensity laser;
- the light filtering device is a narrow band filter with a wavelength of 785 nm, and the light filtering device is used to filter the residual light or interference light of the light source;
- the light power per unit area of the excitation light is 20-150000 mw/cm 2 .
- the autofluorescence collection and processing device includes a photoelectric conversion device, and the photoelectric conversion device is a spectrometer, a photomultiplier tube, or an APD photodetector.
- the photoelectric conversion device is set to one; when this solution is used, the surface scanning mode of the photoelectric conversion device is adopted to identify the parathyroid glands that may be miscut, which takes a long time;
- the photoelectric conversion devices are arranged in a row; the scanning speed of this solution is relatively fast;
- the photoelectric conversion devices are arranged in horizontal rows and vertical rows to form a panel. This method has shorter scanning time and higher cost.
- the autofluorescence collection and processing device includes multiple sets of the same cameras, and filters with different wavelengths are arranged in front of each camera lens, and the wavelengths of the filters are 900 ⁇ 10nm, 830 ⁇ 10nm, 670 ⁇ 10nm.
- the fourth type of identification device also includes a tray, the trustee is transparent on both sides, the specimen is clamped in it, and the thickness of the specimen is within 4 mm. In this way, the thickness of the tissue covered by the parathyroid glands does not exceed 1 mm, so that the detection device of the present invention can fully detect. In this solution, both the photoelectric conversion device and the tray can be moved to complete scanning.
- the fourth type of identification device also includes a dark box. All the components of the above-mentioned fourth type identification device are arranged in a dark box.
- a parathyroid gland recognition device includes a dark box, and the dark box includes:
- the light source mechanism is used to provide a light source for exciting the fluorescence of the sample, and the light source mechanism includes a number of light sources of different wavelengths;
- An imaging mechanism for collecting images of autofluorescence excited by the sample, and the infrared camera can switch the wavelength band of the received light
- the light source mechanism and the imaging mechanism cooperate with each other, and further include a computer, a display screen, and a power supply.
- the computer is located outside the sample chamber.
- the computer is connected to the light source mechanism and the imaging mechanism respectively.
- the display screen is connected to the computer. Connect with light source mechanism, imaging mechanism, computer and display screen;
- the light source mechanism includes a light source turntable, a light source through hole and a plurality of LEDs.
- the LEDs are evenly distributed on a concentric circle of the light source turntable.
- the light source through hole is aligned with one LED. Rotating the light source turntable can switch to the light source through hole.
- the diameter of the light source through hole matches the diameter of the LED; the light source turntable is controlled by the computer;
- the number of the LEDs is 9;
- the emission wavelengths of the LED are 660nm, 680nm, 700nm, 720nm, 740nm, 760nm, 780nm, 800nm, 808nm respectively;
- the imaging mechanism includes an imaging turntable, an imaging through hole, and a number of fluorescent cameras.
- the fluorescent cameras are evenly distributed on a concentric circle of the imaging turntable.
- the imaging through hole is aligned with a fluorescent camera. Rotating the imaging turntable can switch between Fluorescence camera with the imaging through holes aligned, the diameter of the imaging through hole matches the lens size of the fluorescence camera;
- the imaging turntable is controlled by the computer
- the number of the fluorescence cameras is 8;
- the receiving light bands of the fluorescence camera are 685-715nm, 705-735nm, 725-755nm, 745-775nm, 765-795nm, 785-815nm, 805-835nm, 825-855nm, respectively;
- the light source mechanism and the imaging mechanism are arranged at the top of the detection dark box, the sample tray is arranged at the bottom of the detection dark box, and the position of the sample tray corresponds to the position of the imaging mechanism;
- the sample tray is made of light-absorbing material, and the light-absorbing material can absorb light in the 660-808nm band;
- the fluorescence image collected by the imaging mechanism is transferred to the computer, and then transferred to the display screen for display after being processed by the computer.
- the present invention has the following beneficial effects:
- the invention has a good recognition effect. Therefore, for patients with secondary hyperparathyroidism, procedures need to remove the parathyroid glands.
- the invention can identify and remove secondary hyperparathyroidism that is difficult for doctors to find.
- Figure 1 is a spectral analysis diagram of parathyroid glands and surrounding tissues
- Figure 2 is a spectral analysis chart (bar graph) of the parathyroid glands and surrounding tissues
- Figure 3 is a spectrum diagram of the laser light source
- Figure 4 A block diagram of the structure of the first type of identification device
- Figure 5 is a schematic diagram of the structure of a backlight light source
- Fig. 6 is a schematic structural diagram of a movable backlight light source
- Fig. 7 is a comparison diagram of the light source of the present invention and the background art
- Figure 8 is a schematic diagram of the structure of the laser probe
- Figure 9 is a schematic diagram of a large-diameter plastic optical fiber laser probe structure
- Figure 10 is a schematic diagram of the structure of a handheld light source (multiple fibers);
- FIG 11 is a schematic diagram of the structure of a handheld light source (an optical fiber);
- Figure 12 is a schematic diagram of the structure of the spectrometer (single-sided photoreceptor);
- Figure 13 is a schematic diagram of the structure of the spectrometer (double-sided photoreceptor);
- FIG. 14 Schematic diagram of the structure of the tray
- Figure 15 is a schematic diagram of the structure of the optoelectronic device (camera solution).
- Figure 16-1, Figure 16-2, Figure 16-3 are schematic diagrams of the structure of the optoelectronic device (spectrometer, PDA and photomultiplier tube scheme);
- Figure 17 is a schematic diagram of the structure of the optoelectronic device (galvanometer mechanism).
- Figure 18 is a real-time intraoperative photo of the product of the present invention during clinical trials
- Figure 19 is a photograph of a parathyroid gland that was mistakenly cut in the excised tissue during the clinical trial of the product of the present invention.
- Figure 20 is a schematic structural diagram of an embodiment of an autofluorescence collection and processing device
- Figure 21 is a schematic diagram of a handheld parathyroid recognition device
- Figure 22 is a cross-sectional view of the lamp panel of a handheld parathyroid recognition device
- Figure 23 is a side view of the structure of the filter device of the handheld parathyroid recognition device.
- FIG. 24 is a top view of the structure of the filter device of the handheld parathyroid recognition device.
- 1 is the characteristic spectrum of parathyroid gland autofluorescence
- 2 is the characteristic spectrum of thyroid autofluorescence
- 3 is the characteristic spectrum of muscle autofluorescence
- 4 is the characteristic spectrum of fat autofluorescence
- 5 is tracheal autofluorescence Characteristic spectrum.
- the peak intensity of parathyroid autofluorescence is the highest at 822 nm, while other tissues are lower. That is, only after detecting the autofluorescence of various human tissues can parathyroid be formed on the image. The bright spots of the glands or the comparison of spectral analysis can confirm the position of the parathyroid glands.
- the parathyroid glands can be clearly and sharply displayed/identified when the optical power per unit area of the excitation light is in the range of 20-15000 mw/cm 2 , which may reduce the probability of clinical misjudgment.
- Figure 3 is the spectrum 6 of a laser light source with a wavelength of 785nm. It can be seen from Figure 3 that even with a laser light source, there is still afterglow or interference light with a wavelength greater than 785nm. If the interference light is not eliminated, the parathyroid cannot be identified. gland.
- FIG. 4 is a structural block diagram of the device of the present invention.
- the autofluorescence excitation device generates excitation light, which is filtered by the filter device to remove interference light, and then forms a light spot to irradiate human tissues to cause the parathyroid glands to produce autofluorescence.
- Autofluorescence collection and processing The device collects parathyroid autofluorescence and processes it into identifiable information.
- Fig. 5 is a schematic diagram of the structure of a backlight light source, which is used in the first-type identification device.
- Multiple light sources 7 are integrated on a ring-shaped panel 8. When applied, a surface light source is formed on the surgical field on the back of the surgical opening.
- Fig. 6 is a schematic structural diagram of a movable backlight light source.
- the light source 7 is arranged on a movable body 9 to scan the back of the wound to form a surface light source on the surgical field.
- Fig. 7 is a comparison diagram of the light source of the present invention and the background art. Specifically, the technical scheme of the Chinese invention patent with application publication number CN107361744A is compared with the present invention. 11 is the surgical wound, and 10 is the identification spot of the background technical scheme, which is similar to A point light source, 12 is the identification spot of the present invention, which is a surface light source.
- Figure 8 is a schematic diagram of the structure of the laser probe, in which the external light source 17 is connected to a light-emitting fiber 19-1, and the other end of the light-emitting fiber 19-1 is connected to a lens 20 for illuminating the wound surface. It also includes a lighting fiber 19-2 and a lighting fiber One end of 19-2 is connected to the lens 20, and the other end is connected to a spectrum analysis device to assist in the identification of parathyroid glands.
- the solution also includes a hand-held part.
- the hand-held part includes a housing 14.
- the light-incoming fiber 19-1 and the lighting fiber 19-2 are fixed on the housing. Generally, they are detachably connected to facilitate fiber replacement.
- the housing 14 is also equipped with a camera. 16. The image formed by the camera 16 is transmitted to the monitor 13, and the parathyroid gland is identified according to the bright light spot.
- a control panel 15 is also provided on the housing 14.
- Fig. 9 is a schematic diagram of the structure of a large-diameter plastic optical fiber laser probe. It is basically the same as the solution in Fig. 8 except that the light input fiber 19-1 is a large-diameter plastic optical fiber. At this time, the optical fiber can form a surface light source and the lens 20 is omitted.
- Figure 10 is a schematic diagram of the structure of a handheld light source, including an external light source 21.
- the light source 21 integrates several lasers, each laser is connected to an optical fiber, and none of the optical fibers are connected to a lens 22, and several lenses 22 and camera lenses 24 Integrated on the panel 23.
- FIG. 11 is a schematic diagram of the structure of a handheld light source.
- the external light source 21 integrates several lasers. These lasers are coupled together and connected to the lens 22 through an optical fiber.
- the lens 22 and the camera lens 24 are integrated on the panel 23.
- Figure 12 is a schematic diagram of the structure of the spectrometer, including a dark box 25, on which is provided a photoelectric conversion device 27 (or a group of rows or horizontal rows and longitudinal rows) photoelectric conversion device 27, the dark box 25 is provided with a tray 26, the tray Place the excised human tissue to be identified in 26.
- a photoelectric conversion device 27 or a group of rows or horizontal rows and longitudinal rows
- the scheme of Fig. 13 is basically the same as that of Fig. 12, except that two photoelectric conversion devices 27 are provided on the upper and lower sides of the dark box 25 to perform up and down recognition at the same time, and the recognition speed is faster.
- Fig. 14 is a schematic diagram of the structure of the tray.
- the tray 28 includes two upper and lower transparent panels, which hold the excised human tissue to be identified in the middle.
- Fig. 15 is an optoelectronic device adopting a camera solution. Multiple cameras 29 and light sources 30 are set together, and filters of different wavelengths are set in front of each camera lens. Each camera 29 can only image autofluorescence with a specific wavelength. Multiple images are superimposed together to identify the location of the parathyroid gland.
- Figures 16-1, 16-2, and 16-3 are schematic diagrams of the structure of the photoelectric conversion device.
- the photoelectric conversion device can be one of a spectrometer, a PDA, and a photomultiplier tube.
- Figure 16-1 is a line-up solution.
- Figure 16-2 is a horizontal arrangement and vertical arrangement, and
- Figure 16-3 is a photoelectric conversion device arrangement.
- FIG. 17 is a schematic diagram of the structure of the photoelectric conversion device of the galvanometer mechanism, which includes an external light source 32 illuminating the cut tissue, and a galvanometer 33 is arranged under the photoelectric conversion device 31.
- Fig. 18 is a real-time exploration diagram during clinical use. Using the sample handheld identification device of the present invention, two bright spots are identified at the surgical opening, and the bright spot is the parathyroid gland.
- Figure 19 is a parathyroid gland that has been miscut in the excised tissue.
- FIG 20 is a schematic structural diagram of an embodiment of an autofluorescence collection and processing device.
- the peak of the fluorescence generated by the parathyroid gland is about 820nm.
- the excitation effect of light in the 780-790nm band is the most significant.
- the laser 5 used is 785nm, the power is 1.5W, and the laser 1-5 is connected with the power module 1-4 for power supply.
- the control modules 1-3 are respectively connected to the laser 1-5 and the power module 1-4.
- the output current of the power module 1-4 can be controlled by commanding the control module 1-3.
- Connected to the control module 1-3 is provided with a first communication module 1-2, through which the first communication module 1-2 can be wirelessly connected to control the control module 1-3.
- the output end of the laser 1-5 is connected to the optical fiber 1-8, and the generated 785mm laser light is transmitted through the optical fiber.
- the output end of the laser 1-5 is connected to the coupler 1-7 to couple the emitted laser light , Incoming fiber 1-8.
- the traditional quartz fiber has a hard texture and a small diameter. A single fiber cannot transmit high-power lasers. At the same time, it is prone to loss when it is bent. Therefore, the core diameter is large, the texture is soft, the connection is easy, the weight is light, and the transmission bandwidth is large.
- PMMA plastic optical fiber for laser transmission many experiments show that it can reach a transmission efficiency of more than 99%.
- the output end of the laser 1-5 is also provided with a filter 1-6, the pass wavelength of the filter 1-6 is 785nm, and the filter 1-6 is used to filter some stray light generated by the laser 1-5 , Only allow the effective band of 785nm to enter the optical fiber 1-8 for transmission, improving accuracy.
- the other end of the optical fiber 1-8 is connected with a laser probe
- the laser probe includes the probe body 1-9
- the probe body 1-9 is equipped with a collimator 1-10
- one end of the optical fiber 1-8 is inserted into the collimator 1-10 , Transform the transmitted laser light into a parallel beam through the collimator 1-10, and irradiate it to form a light spot, which is applied to the diseased area.
- the surface of the probe body 9 is equipped with a control panel 1-12.
- the control panel 1-12 integrates the functions of physical input and command signal conversion.
- the second communication module 1-11 and the second communication module 1 are connected to the control panel 1-12. -11 is set inside the probe body 1-9, and connects to the control panel 1-12 through the probe body 1-9.
- the second communication module 1-11 is wirelessly connected with the first communication module 1-2, and can wirelessly transmit the command signal input from the control panel 1-12 to the control module 1-3 for control.
- the laser When in use, turn on the power module 1-4, and the laser 1-5 will work to produce 785nm laser.
- the laser passes through the filter 1-6, couples through the coupler 1-7 and enters the optical fiber 1-8 for transmission to the laser probe.
- the probe emits a 785nm laser, and the laser probe is aimed at the diseased area to form a light spot in the diseased area.
- the parathyroid glands in the diseased area are excited by the laser to generate fluorescence, and the generated fluorescence is received and imaged by the fluorescence detection device.
- the command input from the operation control panel 1-12 is converted into a command signal.
- the command signal is wirelessly transmitted to the first communication module 1-2 through the second communication module 1-11, and the control module 1-12 receives the command , Control the power supply module 1-4 to increase the output current, and the output light intensity of the laser 1-5 will increase; otherwise, the output light intensity of the laser 1-5 can be reduced.
- the excitation light used by the ordinary fluorescence detection device can only reach the depth of 3-4mm under the skin.
- the maximum light intensity of this application can penetrate the depth of 4cm under the skin, which can excite the parathyroid glands hidden in other tissues, and cooperate with the fluorescence detection device Can obtain clearer detection results.
- Figure 21-24 is a handheld parathyroid recognition device, including housing 2-10, the front end of housing 2-10 is the detection end, the back end is the gripping end, and the detection end of the housing 2-10 is equipped with infrared
- a light source collection mechanism and a circuit board 2-8 are installed inside the housing 2-10.
- the circuit board 2-8 includes a control module, a communication module and a power supply module. The circuit board is connected with the infrared fluorescence excitation mechanism and the light source collection mechanism.
- the infrared fluorescence excitation mechanism is composed of condenser lens 2-3, lamp panel 2-4, infrared emission tube A 2-2, infrared emission tube B 2-15, infrared emission tube A 2-2 can emit 785nm infrared light, which can be used In conventional parathyroid surgery, the infrared emission tube B 2-15 can emit 665nm infrared light, which can be applied to the surgical detection of other tissues such as thyroid; the lamp panel 2-4 is installed at the front end of the housing and the center of the lamp panel 2-4 A lens through hole 2-12 is opened at the position.
- the condenser lens 2-3 has the same shape and size as the lamp panel 2-4, and is located on the outermost side of the device, parallel to the lamp panel 2-4 and concentric with the lamp panel 2-4. There is a gap between the optical lens 2-3 and the lamp panel 2-4.
- the infrared emitting tube A 2-2 and the infrared emitting tube B 2-15 are arranged in a circular array and installed on the lamp panel 2-4 close to the focusing lens 2-3.
- the circular array arrangement can ensure the uniform intensity of the formed spot;
- the lamp panel 2-4 uses aluminum with good thermal conductivity as the material, when the infrared emission tube A 2-2, the infrared emission tube B 2-15 A large amount of heat is generated during work, and the heat can be quickly dissipated through the aluminum lamp panel 2-4; all the infrared emitting tubes A 2-2 are bundled into a power supply line A 2-5, and the power supply line A 2-5 is energized All infrared emission tubes A 2-2 are lit, infrared emission tubes B 2-15 are bundled into power supply line B 2-6, and power supply line B 2-6 will light up when power supply line B 2-6 is powered on, and power supply line A 2 -5 and power supply line B 2-6 are connected to circuit board 2-8, and the control module in circuit board 2-8 controls power supply line A2-5 to be energized or power supply line B 2-6 to be energized, power supply line A 2- 5 and the power supply line B 2-6 are powered by the power
- the adjustment switches 2-7 can include a switch button for the overall switch of the device, an illumination button for switching bands, and a focusing button for controlling the focal length of the lens. After pressing the corresponding button, the control module on the circuit board 2-8 receives instructions and sends corresponding control instructions to each module.
- the total number of infrared emitting tubes can be selected from 30 to 60, of which infrared emitting tubes A 2-2 are the same as infrared emitting tubes B 2-15, according to infrared emitting tube A 2-2-infrared emitting tube B 2-15-infrared emitting tube A 2-2-Infrared emission tubes B
- the arrangement of 2-15 is arranged in a cross, uniformly distributed in a circular matrix on the surface of the lamp panel 2-4. According to the number of infrared emission tubes used, 2 or 3 rings can be used.
- the intensity of the spot formed by the illuminated area is uniform, there will be no local light intensity difference; when the infrared emission tube emits infrared light, through the outer condenser lens 2-3, all the light is concentrated to the detection area, due to the infrared emission tube The distribution is uniform, and the light intensity in the detection area is uniform.
- the light source collection mechanism is composed of a lens 2-1 and a camera 2-13.
- the lens 2-1 is set in the lens through hole 2-14 in the center of the lamp panel 2-4, and the bottom of the lamp panel 2-4 is provided with a lens holder to connect the lens 2- 1 Fixed, the lens 2-1 is used to collect the autofluorescence light signal emitted by the tissue in the detection area after being excited by infrared light.
- the lens 2-1 passes through the lens through hole 2-14 and is connected to the camera 2-13.
- the received autofluorescence light signal is transmitted to the camera 2-13, which is received by the photosensitive element 2-11 in the camera 2-13 and generates an image.
- the camera 2-13 adopts a high-sensitivity fluorescent camera, which can control the wavelength of the light that needs to be received.
- the filter mechanism 2-12 is composed of a gear wheel 2-16, a rotating shaft 2-17, a motor gear 2-19, and a motor 2-18.
- Shaft 2-17 is located at the center of the gear wheel 2-16.
- Motor gear 2-19 is installed on the output shaft of motor 2-18.
- Motor 2-18 uses a 6mm diameter micro motor.
- Gear wheel 2-16 and motor gear 2-19 mesh with each other. When the motor 2-17 rotates, the motor gear 2-19 on the output shaft rotates, driving the gear wheel 2-16 to rotate around the rotating shaft 2-17; there are two gear wheels on the gear wheel 2-16.
- the filter through holes 2-22, and the two filter through holes 2-22 are respectively equipped with filter A 2-20 and filter B 2-21.
- the filter can filter the light of the ineffective band. Only allow light of effective autofluorescence wavelength to pass through to reduce detection noise. Since the wavelength of autofluorescence is usually greater than the wavelength of about 30nm of the excitation light, the transmission band of filter A 2-20 can be selected as 810-1000nm.
- the transmission band of filter B 2-21 can be selected to be 700-1000nm, used to match infrared emission tube B 2-15, filter A 2-20 and filter B 2-21 uses a filter with a cut-off depth of OD5 or OD6; the filter mechanism is set in front of the photosensitive element in the camera 2-13, and one end of the rotating shaft 2-17 is installed on the bottom of the camera 2-13, and the other end is installed
- the lens holder at the bottom of the lamp panel 2-4 adjust the gear wheel 2-16 to align the filter through hole 2-22 with the photosensitive element to ensure that the inner filter A 20 or filter B 21 is aligned with the photosensitive element.
- the motor 18 is fixedly installed on the base.
- the motor 2-18 When the motor 2-18 rotates, it can drive the gear wheel 2-16 to rotate, so that the positions of the two filter through holes 2-22 are interchanged, and the filter switch is completed to match different Infrared emission tube; the motor 2-18 is connected to the circuit board 2-8 through a circuit, and the rotation control is performed by the control module on the circuit board 2-8, and the power module supplies power to the motor 2-18.
- the light source collection mechanism is connected to the circuit board 2-8.
- the control module on the circuit board 2-8 realizes the control of the camera 2-13, the lens 2-1 and the internal filter mechanism.
- the power module supplies power to the camera 2-13.
- the control module can control the focal length of the lens 2-1; the communication module on the circuit board 2-8 is connected to the computer through wireless signals, when the camera 2-13 auto-fluoresces the tissue collected by the lens 2-1 through the photosensitive element 2 -11 After the image is generated, the obtained image is transmitted to the computer through the communication module and displayed on the computer screen.
- the doctor can directly watch the autofluorescence image of the detection area presented on the screen for diagnosis; at the same time, the doctor can perform the diagnosis on the computer Operation, instructions are transmitted to the control module through the communication module, and the focal length and angle of view of the lens 2-1 can also be set and adjusted.
- the grip 2-9 of the housing 2-24 is provided with a grip 2-9.
- the grip 2-9 is ergonomically designed to facilitate grasping and detection.
- the grip 2-9 is provided with a battery compartment, which is connected to the circuit board through the circuit 2-8 connection to supply power to the power module on the circuit board 2-8.
- the device When using this device for detection, grasp the handle 2-9, select the area to be detected, aim the detection end at the detection area, click the switch of the adjustment button 2-7, the device is turned on; select the 785nm range of the illumination button, and the adjustment button 2-7 generates the adjustment signal.
- the control module on the circuit board 2-8 After the control module on the circuit board 2-8 receives the adjustment signal, it generates an adjustment instruction.
- the control power module supplies power to the power supply line A, and the infrared emission tube A lights up and emits 785nm light. After being converged by the outer focusing lens 2-3, it irradiates the selected detection area to excite the fluorescent substance in the tissue of the detection area to generate autofluorescence.
- the control module generates an adjustment command, and the motor 2-16 runs after receiving the adjustment command.
- the motor gear 2-18 drives the gear wheel 2-15 to rotate around the rotation axis 2-16 until the filter through hole 2-22 is aligned with the photosensitive element 2-11 inside the camera 2-13, so that the filter A covers the photosensitive element 2 -11;
- the autofluorescence generated by the tissue is collected by the lens 2-1, filtered by the filter mechanism 2-12 and then transmitted to the camera 2-13. Because it is excited by 785nm light, the effective autofluorescence generated by the tissue has a wavelength of about 815nm For example, the autofluorescence wavelength of the parathyroid glands in common parathyroid surgery is 820nm.
- the transmission wavelength of filter A is 810-1000nm
- the light in the wavelength band is filtered by the filter A, and the effective autofluorescence is converted by the photosensitive element 2-11 to convert the light signal into an image, and the generated image is sent to the computer via the communication module on the circuit board 2-8, and then the computer screen
- the doctor can directly watch the screen to observe the condition of the detected area; when the displayed image is not clear, the doctor can operate the computer to issue instructions.
- the instructions are transmitted to the control module through the communication module on the circuit board 2-8, and the control module
- the module adjusts the parameters such as the focal length and angle of view of the lens 2-1, and the above parameters can also be adjusted through the focal length button of the adjustment button 2-7.
- move the device directly align the infrared fluorescence excitation mechanism to the next area to be detected, repeat the above process to complete the detection, and the doctor can directly move the device to complete the detection and observation of the positive area tissue . Because the fluorescent substances in different tissues are excited by different wavelengths of light to different extents, using the 785nm band may not be suitable for excitation detection of other tissues.
- the autofluorescence band of the thyroid is 700nm, and 785nm excitation light cannot be used, in order to distinguish between thyroid and parathyroid
- the fluorescence image of the gland can be switched with this device for the excitation light band.
- the motor 2-17 runs after receiving the adjustment command, and the motor gear 2-18 drives the gear wheel 2-15 to rotate Axis 2-16 rotates to another filter through hole 2-22 aligned with the photosensitive element 2-11, so that the filter B covers the photosensitive element 2-11, and completes the filter adaptation of the 665nm excitation light, using 665nm light Repeat the above operation to complete the detection and observation of the area using 665nm light.
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Abstract
Description
Claims (50)
- 一种甲状旁腺识别装置,包括A parathyroid gland recognition device, comprising自体荧光激发装置,用于产生650-810nm的激发光,照射人体组织,使甲状旁腺产生自体荧光;和Autofluorescence excitation device, used to generate 650-810nm excitation light, irradiate human tissues, and make parathyroid glands produce autofluorescence; and自体荧光采集处理装置,采集甲状旁腺自体荧光,并处理成可识别的信息;Autofluorescence acquisition and processing device, collects parathyroid autofluorescence, and processes it into identifiable information;其特征是,还包括滤光装置,所述滤光装置透过波长为810nm,使光源的干扰光无法透过,避免干扰甲状旁腺识别。It is characterized in that it also includes a light filtering device, the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, so as to avoid interference with the identification of the parathyroid gland.
- 根据权利要求1所述的甲状旁腺识别装置,其特征是,所述激发光的单位面积的光功率为20-150000mw/cm 2。 The parathyroid recognition device according to claim 1, wherein the light power per unit area of the excitation light is 20-150000 mW/cm 2 .
- 根据权利要求1所述的甲状旁腺识别装置,其特征是,所述激发光的单位面积的光功率为20-100mw/cm 2,所述激发光形成的光斑面积为50-200cm 2。 The parathyroid recognition device according to claim 1, wherein the light power per unit area of the excitation light is 20-100 mW/cm 2 , and the spot area formed by the excitation light is 50-200 cm 2 .
- 根据权利要求1所述的甲状旁腺识别装置,其特征是,所述激发光的单位面积的光功率为100-15000mw/cm 2,所述激发光形成的光斑面积为0.1-1cm 2。 The parathyroid recognition device according to claim 1, wherein the light power per unit area of the excitation light is 100-15000 mW/cm 2 , and the spot area formed by the excitation light is 0.1-1 cm 2 .
- 根据权利要求1所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括光源,所述光源为激光器、LED、氙灯、卤素灯中的一种或任几种的组合。The parathyroid gland recognition device according to claim 1, wherein the autofluorescence excitation device comprises a light source, and the light source is one or a combination of any of a laser, an LED, a xenon lamp, and a halogen lamp.
- 根据权利要求5所述的甲状旁腺识别装置,其特征是,所述光源为一个或多个激光器,所述单个激光器的功率为W级。The parathyroid recognition device according to claim 5, wherein the light source is one or more lasers, and the power of the single laser is W class.
- 根据权利要求5或6所述的甲状旁腺识别装置,其特征是,所述激光器为结构光激光器。The parathyroid gland identification device according to claim 5 or 6, wherein the laser is a structured light laser.
- 一种甲状旁腺识别装置,包括A parathyroid gland recognition device, comprising自体荧光激发装置,产生的激发光形成激发光斑,照射人体组织,使甲状 旁腺产生自体荧光;Autofluorescence excitation device, the excitation light generated forms an excitation light spot, which irradiates human tissues and makes the parathyroid glands produce autofluorescence;自体荧光采集处理装置,采集甲状旁腺自体荧光,并处理成可识别的信息;和Autofluorescence acquisition and processing device, which collects parathyroid autofluorescence and processes it into identifiable information; and滤光装置,所述滤光装置透过波长为810nm,使光源的干扰光无法透过,避免干扰甲状旁腺识别;A light filtering device, the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, and avoiding interference with the identification of the parathyroid gland;其特征是,所述自体荧光采集处理装置为红外摄像机,对创面进行成像,亮点是甲状旁腺;所述激发光斑的面积基本覆盖手术创面。It is characterized in that the autofluorescence acquisition and processing device is an infrared camera, which images the wound surface, and the bright spot is the parathyroid gland; the area of the excitation light spot basically covers the surgical wound surface.
- 根据权利要求8所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个内置独立的光源,该独立光源由多个激光器排列而成。8. The parathyroid recognition device according to claim 8, wherein the autofluorescence excitation device comprises a built-in independent light source, and the independent light source is formed by arranging a plurality of lasers.
- 根据权利要求9所述的甲状旁腺识别装置,其特征是,所述红外摄像机包括镜头,多个激光器与镜头基本排列在同一平面上。The parathyroid recognition device according to claim 9, wherein the infrared camera includes a lens, and a plurality of lasers and the lens are basically arranged on the same plane.
- 根据权利要求10所述的甲状旁腺识别装置,其特征是,所述多个激光器为环形排列、同心圆式排列或方形排列。The parathyroid gland recognition device according to claim 10, wherein the plurality of lasers are arranged in a circular arrangement, a concentric arrangement or a square arrangement.
- 根据权利要求9至11任一项所述的甲状旁腺识别装置,其特征是,还设置散热装置,给多个激光器提供散热功能。The parathyroid gland recognition device according to any one of claims 9 to 11, wherein a heat dissipation device is further provided to provide heat dissipation function for the plurality of lasers.
- 根据权利要求8所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个外置光源,所述外置光源直接或间接连接单根石英光纤,所述石英光纤另一端连接镜头,使点状光变成面状光。The parathyroid gland recognition device according to claim 8, wherein the autofluorescence excitation device comprises an external light source, the external light source is directly or indirectly connected to a single quartz optical fiber, and the other end of the quartz optical fiber Connect the lens to change the spot light to the surface light.
- 根据权利要求13所述的甲状旁腺识别装置,其特征是,所述外置光源为一个激光器或多个激光器耦合。The parathyroid recognition device according to claim 13, wherein the external light source is one laser or multiple lasers coupled.
- 根据权利要求8所述的甲状旁腺识别装置,其特征是,所述自体荧光 激发装置,包括一个外置光源,所述外置光源包含多个激光器,每个激光器直接或间接连接一根石英光纤,所述多根光纤另一端成束或者连接镜头。The parathyroid gland recognition device according to claim 8, wherein the autofluorescence excitation device comprises an external light source, and the external light source comprises a plurality of lasers, and each laser is directly or indirectly connected to a quartz Optical fibers, the other ends of the multiple optical fibers are bundled or connected to a lens.
- 根据权利要求8所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个外置光源,所述外置光源直接或间接连接塑料光纤,所述塑料光纤直径大于2mm。The parathyroid gland recognition device according to claim 8, wherein the autofluorescence excitation device comprises an external light source, and the external light source is directly or indirectly connected to a plastic optical fiber, the diameter of the plastic optical fiber is greater than 2 mm.
- 根据权利要求8所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个环形的光源,照射创面的背部。The parathyroid gland recognition device according to claim 8, wherein the autofluorescence excitation device includes a circular light source to illuminate the back of the wound.
- 根据权利要求8所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个移动式的光源,照射创面的背部。The parathyroid gland recognition device according to claim 8, wherein the autofluorescence excitation device includes a mobile light source to illuminate the back of the wound.
- 一种甲状旁腺识别装置,包括A parathyroid gland recognition device, comprising自体荧光激发装置,产生的激发光形成激发光斑,照射人体组织,使甲状旁腺产生自体荧光;Autofluorescence excitation device, the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;自体荧光采集处理装置,采集甲状旁腺自体荧光,并处理成可识别的信息;和Autofluorescence acquisition and processing device, which collects parathyroid autofluorescence and processes it into identifiable information; and滤光装置,所述滤光装置透过波长为810nm,使光源的干扰光无法透过,避免干扰甲状旁腺识别;A light filtering device, the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, and avoiding interference with the identification of the parathyroid gland;其特征是,所述自体荧光激发装置包括光源;It is characterized in that the autofluorescence excitation device includes a light source;还包括激光探针,激光探针设有光纤,其中一根光纤连接光源,称为发光光纤,所述激发光的单位面积的光功率为100-15000mw/cm 2,所述激发光形成的光斑面积为0.1-1cm 2。 It also includes a laser probe. The laser probe is equipped with optical fibers. One of the optical fibers is connected to a light source, called a luminescent fiber. The light power per unit area of the excitation light is 100-15000 mw/cm 2 , and the light spot formed by the excitation light The area is 0.1-1cm 2 .
- 根据权利要求19所述的甲状旁腺识别装置,其特征是,所述自体荧光 采集处理装置,包括一个外置的摄像机,照射创面,采集甲状旁腺自体荧光,并处理成可识别的图像信息。The parathyroid gland recognition device according to claim 19, wherein the autofluorescence collection and processing device comprises an external camera, which irradiates the wound surface, collects the parathyroid autofluorescence, and processes it into identifiable image information .
- 根据权利要求19所述的甲状旁腺识别装置,其特征是,所述自体荧光采集处理装置,还包括光谱分析装置,激光探针设有两根光纤,其中一根光纤连接光源,称为发光光纤,另一根连接光谱分析装置,称为采光光纤。The parathyroid recognition device according to claim 19, wherein the autofluorescence collection and processing device further comprises a spectrum analysis device, and the laser probe is provided with two optical fibers, one of which is connected to the light source, called luminescence The optical fiber, and the other connected to the spectrum analysis device, is called the daylighting optical fiber.
- 根据权利要求21所述的甲状旁腺识别装置,其特征是,所述光谱分析装置为光谱仪、光电倍增管或APD光电探测器中的一种;光谱分析装置通过收集采光光纤传回自体荧光,通过分析甲状旁腺的特殊光谱的波长和强度值,确定甲状旁腺的位置。The parathyroid gland identification device according to claim 21, wherein the spectrum analysis device is one of a spectrometer, a photomultiplier tube, or an APD photodetector; the spectrum analysis device transmits back autofluorescence through a light collecting fiber, Determine the location of the parathyroid glands by analyzing the wavelength and intensity values of the special spectrum of the parathyroid glands.
- 根据权利要求19所述的甲状旁腺识别装置,其特征是,所述自体荧光采集处理装置,还包括报警装置,当光谱分析装置确定甲状旁腺位置后,发出报警信息,提示医生。The parathyroid gland identification device according to claim 19, characterized in that the autofluorescence acquisition and processing device further comprises an alarm device, when the spectral analysis device determines the position of the parathyroid gland, an alarm message is issued to remind the doctor.
- 根据权利要求19所述的甲状旁腺识别装置,其特征是,所述激光探针包括手持部,在手持部上还包括小型摄像器,所述小型摄像器连接图像显示装置。The parathyroid recognition device according to claim 19, wherein the laser probe includes a hand-held part, and the hand-held part further comprises a small camera, and the small camera is connected to an image display device.
- 一种甲状旁腺识别装置,包括A parathyroid gland recognition device, comprising自体荧光激发装置,产生的激发光形成激发光斑,照射人体组织,使甲状旁腺产生自体荧光;Autofluorescence excitation device, the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;自体荧光采集处理装置,采集甲状旁腺自体荧光,并处理成可识别的信息;和Autofluorescence acquisition and processing device, which collects parathyroid autofluorescence and processes it into identifiable information; and滤光装置,所述滤光装置透过波长为810nm,使光源的干扰光无法透过,避免干扰甲状旁腺识别;A light filtering device, the transmission wavelength of the light filtering device is 810 nm, so that the interference light of the light source cannot be transmitted, and avoiding interference with the identification of the parathyroid gland;其特征是,其特征是,所述激发光的单位面积的光功率为100-15000mw/cm 2,所述激发光形成的光斑面积为0.1-1cm 2。 It is characterized in that the light power per unit area of the excitation light is 100-15000 mW/cm 2 , and the spot area formed by the excitation light is 0.1-1 cm 2 .
- 根据权利要求25所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置、自体荧光采集处理装置和滤光装置集成在壳体内。The parathyroid gland recognition device according to claim 25, wherein the autofluorescence excitation device, the autofluorescence collection and processing device, and the filter device are integrated in a housing.
- 根据权利要求26所述的甲状旁腺识别装置,其特征是,自体荧光采集处理装置,包括摄像机,所述摄像机包括镜头,镜头与自体荧光激发装置集成在一起。The parathyroid gland recognition device according to claim 26, wherein the autofluorescence collection and processing device includes a camera, the camera includes a lens, and the lens is integrated with the autofluorescence excitation device.
- 根据权利要求27所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置包括内置光源,所述内置光源包括多个激光器,所述多个激光器与镜头集成在一起。The parathyroid gland recognition device according to claim 27, wherein the autofluorescence excitation device includes a built-in light source, the built-in light source includes a plurality of lasers, and the plurality of lasers are integrated with a lens.
- 根据权利要求25所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个外置光源,所述外置光源直接或间接连接单根石英光纤,所述石英光纤另一端连接镜头,使点状光变成面状光。该方案中,外置光源可为一个激光器或多个激光器耦合。The parathyroid gland recognition device according to claim 25, wherein the autofluorescence excitation device comprises an external light source, and the external light source is directly or indirectly connected to a single quartz optical fiber, and the other end of the quartz optical fiber Connect the lens to change the spot light to the surface light. In this solution, the external light source can be one laser or multiple lasers coupled.
- 根据权利要求25所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个外置光源,所述外置光源包含多个激光器,每个激光器直接或间接连接多根石英光纤,所述多根光纤另一端成束或者连接镜头。The parathyroid gland recognition device according to claim 25, wherein the autofluorescence excitation device comprises an external light source, and the external light source comprises multiple lasers, and each laser is directly or indirectly connected to multiple quartz crystals. Optical fibers, the other ends of the multiple optical fibers are bundled or connected to a lens.
- 根据权利要求25所述的甲状旁腺识别装置,其特征是,所述自体荧光激发装置,包括一个外置光源,所述外置光源直接或间接连接塑料光纤,所述塑料光纤直径大于2mm。The parathyroid recognition device according to claim 25, wherein the autofluorescence excitation device comprises an external light source, and the external light source is directly or indirectly connected to a plastic optical fiber, the diameter of the plastic optical fiber is greater than 2 mm.
- 一种甲状旁腺识别装置,其特征是,包括壳体,所述壳体前端为探测端,后端为抓握端,探测端设有用于激发人体自发荧光的红外荧光激发机构, 所述壳体内设有用于收集人体自发荧光并生成图像的光源收集机构和电路板,所述光源收集机构包括设置于壳体内部的摄像机和设置于探测端并与摄像机相连的镜头,所述电路板与红外荧光激发机构和光源收集机构通过线路相连,电路板,包括控制模块、通讯模块、电源模块,各模块之间通过线路相连,其中,所述控制模块,用于对红外荧光激发机构、光源收集机构和各模块进行控制;所述通讯模块,通过无线信号与计算机连接,用于将光源收集机构所生成图像传输至计算机,用于通过计算机对光源收集机构进行控制。A parathyroid gland recognition device, which is characterized in that it comprises a housing, the front end of the housing is a detection end, the back end is a gripping end, and the detection end is provided with an infrared fluorescence excitation mechanism for stimulating autofluorescence of the human body. The body is provided with a light source collection mechanism and a circuit board for collecting autofluorescence of the human body and generating images. The light source collection mechanism includes a camera arranged inside the housing and a lens arranged at the detection end and connected to the camera. The circuit board is connected to the infrared The fluorescence excitation mechanism and the light source collection mechanism are connected by wires. The circuit board includes a control module, a communication module, and a power supply module. The modules are connected by wires. The control module is used for the infrared fluorescence excitation mechanism and the light source collection mechanism. Control with each module; the communication module is connected with a computer through a wireless signal, and is used to transmit the image generated by the light source collection mechanism to the computer, and is used to control the light source collection mechanism through the computer.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述电源模块用于对红外荧光激发机构、光源收集机构和各模块进行供电。The parathyroid gland recognition device according to claim 32, wherein the power supply module is used to supply power to the infrared fluorescence excitation mechanism, the light source collection mechanism and each module.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述红外荧光激发机构包括设置于壳体前端的灯盘,所述灯盘中部设有镜头通孔,灯盘前端平行设有聚焦透镜,聚焦透镜与灯盘之间的灯盘表面上围绕镜头通孔设置有若干红外线发射管。The parathyroid gland recognition device according to claim 32, wherein the infrared fluorescence excitation mechanism comprises a lamp panel arranged at the front end of the housing, a lens through hole is arranged in the middle of the lamp panel, and the front end of the lamp panel is arranged in parallel. A focusing lens, a plurality of infrared emitting tubes are arranged on the surface of the lamp panel between the focusing lens and the lamp panel around the lens through hole.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述镜头设置于镜头通孔内。The parathyroid recognition device according to claim 32, wherein the lens is arranged in the lens through hole.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述摄像机包括感光元件,所述感光元件前设有滤光机构,所述滤光机构包括齿轮转盘、电机齿轮与电机,所述齿轮转盘中心设有转动轴,齿轮转盘与电机齿轮相互啮合,电机齿轮轴心与电机的输出轴连接,电机带动电机齿轮转动,从而带动相啮合的齿轮转盘沿转动轴转动,齿轮转盘上围绕转轴设有若干滤光片通孔,转盘转动至对应位置时,滤光片通孔与感光元件位置对正,滤光片通孔内设有滤光片。The parathyroid recognition device according to claim 32, wherein the camera includes a photosensitive element, and a filter mechanism is arranged in front of the photosensitive element, and the filter mechanism includes a gear wheel, a motor gear, and a motor. The center of the gear turntable is provided with a rotating shaft. The gear turntable meshes with the motor gears. The motor gear shaft is connected to the output shaft of the motor. The motor drives the motor gears to rotate. The rotating shaft is provided with a plurality of filter through holes. When the turntable rotates to a corresponding position, the filter through hole is aligned with the position of the photosensitive element, and a filter is arranged in the filter through hole.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述红外线发 射管为环形阵列排列,数量为20-100根。The parathyroid recognition device according to claim 32, wherein the infrared emitting tubes are arranged in a circular array, and the number is 20-100.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述滤光片通孔有两个,两个滤光片通孔内分别设有透光波段为810-1000nm滤光片A和透光波段为700-1000nm的滤光片B。The parathyroid recognition device according to claim 32, wherein there are two through-holes for the filter, and the two through-holes for the filter are respectively provided with a light-transmitting band of 810-1000nm filter A And filter B with a transmission wavelength of 700-1000nm.
- 根据权利要求32所述的甲状旁腺识别装置,其特征是,所述壳体上设有调节开关,调节开关与电路板通过线路相连,所述抓握端设有人体力学握把,所述握把内部设有电池仓,所述电池仓通过线路与电源模块连接。The parathyroid gland recognition device according to claim 32, wherein an adjustment switch is provided on the housing, and the adjustment switch is connected to the circuit board by a line, and the grip end is provided with a human mechanics grip, the A battery compartment is arranged inside the grip, and the battery compartment is connected to the power supply module through a line.
- 一种甲状旁腺识别装置,包括A parathyroid gland recognition device, comprising自体荧光激发装置,产生的激发光形成激发光斑,照射人体组织,使甲状旁腺产生自体荧光;Autofluorescence excitation device, the excitation light generated forms an excitation spot, which irradiates human tissues, and makes the parathyroid glands produce autofluorescence;自体荧光采集处理装置,采集甲状旁腺自体荧光,并处理成可识别的信息;和Autofluorescence acquisition and processing device, which collects parathyroid autofluorescence and processes it into identifiable information; and滤光装置,使光源的干扰光无法透过,避免干扰甲状旁腺识别;Filtering device, so that the interference light of the light source cannot pass through, avoiding interference with parathyroid recognition;其特征是,所述自体荧光激发装置,包括光源,所述光源为LED光源、半导体点状激光器、激光器或vcsel均匀场强激光器;It is characterized in that, the autofluorescence excitation device includes a light source, and the light source is an LED light source, a semiconductor point laser, a laser or a vcsel uniform field intensity laser;所述滤光装置为波长785nm窄带滤光片;The filter device is a narrowband filter with a wavelength of 785 nm;所述激发光的单位面积的光功率为20-150000mw/cm 2。 The light power per unit area of the excitation light is 20-150000 mw/cm 2 .
- 根据权利要求40所述的甲状旁腺识别装置,其特征是,所述自体荧光采集处理装置,包括光电转换装置,所述光电转换装置为光谱仪、光电倍增管或APD光电探测器。The parathyroid gland recognition device of claim 40, wherein the autofluorescence collection and processing device comprises a photoelectric conversion device, and the photoelectric conversion device is a spectrometer, a photomultiplier tube, or an APD photodetector.
- 根据权利要求40所述的甲状旁腺识别装置,其特征是,所述自体荧光采集处理装置,包括多组相同的相机,每个相机镜头前设置不同波长的滤光片, 所述滤光片的波长为900±10nm、、830±10nm、670±10nm。The parathyroid gland recognition device according to claim 40, wherein the autofluorescence acquisition and processing device comprises multiple sets of the same cameras, and filters of different wavelengths are arranged in front of the lens of each camera, and the filter The wavelengths are 900±10nm, 830±10nm, 670±10nm.
- 根据权利要求40所述的甲状旁腺识别装置,其特征是,还包括托盘,所述托管双面透明的,标本夹在其中,标本的厚度在4mm以内。The parathyroid gland recognition device according to claim 40, further comprising a tray, the trustee is transparent on both sides, the specimen is clamped in it, and the thickness of the specimen is within 4 mm.
- 根据权利要求40所述的甲状旁腺识别装置,其特征是,还包括一个暗箱。The parathyroid recognition device according to claim 40, further comprising a dark box.
- 一种甲状旁腺识别装置,包括暗箱,所述暗箱内包括:A parathyroid gland recognition device includes a dark box, and the dark box includes:光源机构,用于提供激发样品荧光的光源,所述光源机构包括若干不同波长光源;The light source mechanism is used to provide a light source for exciting the fluorescence of the sample, and the light source mechanism includes several light sources of different wavelengths;成像机构,用于收集样品被激发出的自发荧光的图像,所述成像机构可以切换所接收光的波段;An imaging mechanism for collecting images of autofluorescence excited by the sample, and the imaging mechanism can switch the wavelength band of the received light;样品托盘,用于放置样品;Sample tray for placing samples;所述光源机构与成像机构相互配合,还包括计算机、显示屏和电源。The light source mechanism cooperates with the imaging mechanism and also includes a computer, a display screen and a power supply.
- 根据权利要求45所述的甲状旁腺识别装置,其特征是,所述计算机设于样品仓外,计算机分别与光源机构、成像机构连接,所述显示屏与计算机连接,所述电源分别与光源机构、成像机构、计算机和显示屏连接;The parathyroid gland recognition device according to claim 45, wherein the computer is located outside the sample chamber, the computer is respectively connected to the light source mechanism and the imaging mechanism, the display screen is connected to the computer, and the power source is respectively connected to the light source. Connection of mechanism, imaging mechanism, computer and display screen;其中,所述光源机构包括光源转盘、光源通孔和若干LED,所述LED均匀分布在光源转盘的一个同心圆上,所述光源通孔与一个LED对齐,转动光源转盘可以切换与光源通孔对齐的LED光源通孔的直径与LED直径相匹配;Wherein, the light source mechanism includes a light source turntable, a light source through hole and a plurality of LEDs. The LEDs are evenly distributed on a concentric circle of the light source turntable. The light source through hole is aligned with one LED. Rotating the light source turntable can switch to the light source through hole. The diameter of the aligned LED light source through hole matches the LED diameter;所述光源转盘由所述计算机控制;其中,所述LED的数量为9个;The light source turntable is controlled by the computer; wherein the number of the LEDs is 9;其中,所述LED的发射波长分别为660nm、680nm、700nm、720nm、740nm、760nm、780nm、800nm、808nm;Wherein, the emission wavelengths of the LED are 660nm, 680nm, 700nm, 720nm, 740nm, 760nm, 780nm, 800nm, 808nm respectively;其中,所述成像机构包括成像转盘、成像通孔和若干荧光相机,所述荧光 相机均匀分布在成像转盘的一个同心圆上,所述成像通孔与一个荧光相机对齐,转动成像转盘可以切换与成像通孔对齐的荧光相机,成像通孔的直径与荧光相机的镜头尺寸相匹配;所述成像转盘由所述计算机控制。Wherein, the imaging mechanism includes an imaging turntable, an imaging through hole, and a number of fluorescent cameras. The fluorescent cameras are evenly distributed on a concentric circle of the imaging turntable. The imaging through hole is aligned with a fluorescent camera. Rotating the imaging turntable can switch between For the fluorescent camera with the imaging through holes aligned, the diameter of the imaging through hole matches the lens size of the fluorescent camera; the imaging turntable is controlled by the computer.
- 根据权利要求46所述的甲状旁腺识别装置,其特征是,所述荧光相机的数量为8个;所述荧光相机的接收光波段分别为685-715nm、705-735nm、725-755nm、745-775nm、765-795nm、785-815nm、805-835nm、825-855nm。The parathyroid gland recognition device according to claim 46, wherein the number of the fluorescence camera is 8; the light receiving wavelength bands of the fluorescence camera are 685-715nm, 705-735nm, 725-755nm, 745. -775nm, 765-795nm, 785-815nm, 805-835nm, 825-855nm.
- 根据权利要求47所述的甲状旁腺识别装置,其特征是,所述光源机构与成像机构设于检测暗箱的顶部,所述样品托盘设于检测暗箱的底部,样品托盘的位置与成像机构位置相对应。The parathyroid identification device according to claim 47, wherein the light source mechanism and the imaging mechanism are arranged on the top of the detection dark box, the sample tray is arranged on the bottom of the detection dark box, and the position of the sample tray and the position of the imaging mechanism Corresponding.
- 一种甲状旁腺识别系统,其特征是,包括权利要求8、权利要求19、权利要求40的甲状旁腺识别装置。A parathyroid gland recognition system, characterized by comprising the parathyroid gland recognition device of claim 8, claim 19, and claim 40.
- 一种甲状旁腺识别系统,其特征是,包括权利要求8、权利要求25、权利要求40的甲状旁腺识别装置。A parathyroid gland recognition system, characterized by comprising the parathyroid gland recognition device of claim 8, claim 25, and claim 40.
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CN112155562A (en) * | 2020-10-20 | 2021-01-01 | 湖南马尼克医疗科技有限公司 | Parathyroid gland composite detection device |
CN113067240A (en) * | 2021-03-24 | 2021-07-02 | 山东大学 | High repetition frequency self-mode-locking aureoemer laser and application thereof in parathyroid gland identification |
FR3135610A1 (en) * | 2022-05-19 | 2023-11-24 | Fluoptics | Medical imaging device and method adapted to the observation of several spectral bands |
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