WO2020162596A1

WO2020162596A1 - Drug solution injection device and drug solution injection system

Info

Publication number: WO2020162596A1
Application number: PCT/JP2020/004821
Authority: WO
Inventors: 根本　茂; 由美子吹越; 利雄金高
Original assignee: 株式会社サーキュラス
Priority date: 2019-02-08
Filing date: 2020-02-07
Publication date: 2020-08-13
Also published as: JPWO2020162596A1

Abstract

This drug solution injection device is provided with an injection head and a control unit, and, regarding at least a first drug solution, draws the first drug solution from a drug solution container into a first syringe. The control unit is configured to perform: a process for displaying information concerning the concentration of a contrast agent that is the first drug solution and information concerning a condition of mixing the first drug solution and a second drug solution; a process for accepting a change in the concentration of the contrast agent; and a process for changing the condition of mixing the first and second drug solutions in accordance with the changed concentration of the contrast agent and for displaying information concerning the changed mixing condition.

Description

Chemical injection device and chemical injection system

The present invention relates to a drug solution injecting device for delivering a drug solution such as a contrast agent to a subject and a system including the same, and in particular, even if a method of injecting a contrast agent by inhaling a contrast agent from a drug solution container TECHNICAL FIELD The present invention relates to a drug injection device capable of injecting a drug solution with various contrast agent concentrations without preparing different types of contrast agents in advance and changing the concentration with good operability, and a drug solution injection system including the same. ..

As a medical image diagnostic apparatus, a CT (Computed Tomography) scanner, an MRI (Magnetic Resonance Imaging) apparatus, a PET (Positron Emission Tomography) apparatus, an ultrasonic diagnostic apparatus, an angiography (angiography) imaging apparatus, etc. are known. .. When using such an imaging device, a contrast agent, physiological saline, or the like (hereinafter, simply referred to as “medicine solution”) may be injected into a patient.

The drug solution is generally filled in a syringe having a cylinder and a piston. A drug solution injector is generally used to inject a drug solution filled in a syringe. The chemical injection device has a syringe holding mechanism and a piston drive mechanism, and advances the piston by the piston drive mechanism in a state where the syringe is held by the syringe holding mechanism, so that the drug solution filled in the syringe is examined. Can be injected into. In addition, as another aspect, a device for injecting a drug solution stored in a container such as a drug solution bag or a drug solution bottle toward a subject instead of a syringe is also known in the related art.

Different types of contrast agents are used depending on the type such as CT examination and MRI examination. For example, in the case of CT examination, iodine contrast agent containing iodine is used. In addition, a plurality of types of iodine contrast agents having different iodine contents are commercially available (for example, 240 mgI/mL, 300 mgI/mL, 320 mgI/mL, 350 mgI/mL, 370 mgI/mL, etc.).

As a drug solution injecting device, there is also known one that holds a syringe filled with a contrast agent and a syringe filled with physiological saline, and simultaneously injects them to dilute the contrast agent for injection ( For example, Patent Document 1).

WO2011/125987

The injection conditions for diluting the contrast medium and physiological saline are, for example, 350 mgI/mL contrast medium is used, the mixing ratio is set to 50%, and the liquid medicine is injected at a predetermined injection speed and injection amount. Is set. On the other hand, depending on the hospital facility or procedure, for example, it may be desired to set the injection protocol with a contrast agent of 300 mgI/mL instead of the contrast agent of 350 mgI/mL. When trying to deal with this by changing the admixture conditions without replacing the mounted contrast agent, for example, by changing the admixture ratio from 50% to 40% (one example), an image equivalent to 300 mgI/mL can be obtained. It is possible to set the injection conditions so that the agent is attached.

However, with the above setting method, it is difficult to intuitively change the concentration of the contrast agent. This problem can be avoided by changing the syringe or contrast agent bottle etc. mounted on the drug solution injector from 350 mgI/mL to 300 mgI/mL, but in this case, it is necessary to prepare multiple types of syringes in advance. This may cause a problem that it must be done and the labor of the work is complicated.

Therefore, an object of the present invention is to inject a liquid medicine having various contrast agent concentrations without preparing a plurality of kinds of contrast agents having different concentrations in advance, even in the method of injecting the contrast agent by sucking the contrast agent from the liquid medicine container. Another object of the present invention is to provide a drug solution injector and the like that can change the concentration of the drug solution with good operability.

In order to achieve the above object, one mode of the present invention is as follows:
An injection head that holds a first syringe filled with a first drug solution and a second syringe filled with a second drug solution, and is capable of mixing and injecting the first and second drug solutions,
A control unit that provides a graphical user interface for setting a drug injection protocol;
Equipped with
At least with respect to the first drug solution, a drug solution injector for sucking the first drug solution into the first syringe from a drug solution container,
The control unit is
A process of displaying information about the concentration of the contrast agent, which is the first drug solution, and information about the mixing condition of the first and second drug solutions;
A process of accepting a change in the concentration of the contrast agent,
A process of changing the mixing condition of the first and second chemical solutions corresponding to the changed contrast agent concentration and displaying information on the changed mixing condition;
A chemical injection device configured to perform.

(Explanation of terms)
The “medicine solution” refers to, for example, a contrast agent, physiological saline, or a mixture thereof.
Specific examples of the “contrast agent” include a contrast agent having an iodine concentration of 240 mgI/mL (for example, a viscosity at 37° C. of 3.3 Pa·s and a specific gravity of 1.268 to 1.296), and a contrast agent having an iodine concentration of 300 mgI/mL ( For example, a contrast agent having a viscosity of 6.1 mPa·s at 37° C. and a specific gravity of 1.335 to 1.371 and an iodine concentration of 350 mgI/mL (for example, a viscosity of 10.6 mPa·s at 37° C. and a specific gravity of 1.392 to 1.372). 433) and so on.
Specific examples of the "physiological saline" include physiological saline containing 180 mg of sodium chloride in 20 ml of physiological saline (eg, a viscosity of 0.9595 mPa·s at 20° C., a specific gravity of 1.004 to 1.006). is there.
The “injection protocol” indicates what kind of liquid medicine is injected, how much, at what speed and at what time. The injection protocol may include pressure conditions such as the pressure at which the injection is performed.
The “IC tag” refers to a small non-contact type electronic device that has an IC chip, an antenna, and the like and receives a radio wave, and may be synonymous with an RFID tag in the context of this specification.
The “control unit” is a unit that has a CPU, a memory, and the like and performs arithmetic processing or a unit including the same. A “controller”, a “controller unit”, a “controller circuit (control circuit)”, and a “controller module (control) Module)”, “processor unit”, “processor unit”, “processor module”, and the like. A "control unit" may be configured as comprising a microcomputer, microcontroller, programmable logic controller, application specific integrated circuit, other programmable circuit, etc. In the present specification, the “control unit” may physically have one configuration, but two or three or more control units functionally cooperate to configure one “control unit”. May be

The “computer program” may read a storage medium storing it by a predetermined device/device/mechanism or the like to operate those computers with a predetermined function. In this case, the storage medium storing the computer program constitutes one form of the present invention. Further, the computer program may be provided via a communication network (Internet in one example). The computer program may be a so-called difference program that can be realized in combination with a program already recorded in the computer.

“Part (which can also be expressed as “element” or “module” etc.)”-in this specification, for example, what is expressed by “(function name)”+“part” can be realized as a function realized by a computer. It is a thing. Such “parts (elements, modules, etc.)” may be provided in any device in the system. Further, it is not always necessary to provide the device in one device, and the corresponding function may be provided in a distributed manner in two or more devices. Further, only one or more predetermined “units” may be provided in an external server or the like via a communication network (for example, the Internet).

It should be noted that the various constituent elements (devices, devices, units, modules, etc.) referred to in the present specification do not have to be independent, and a plurality of constituent elements are configured as one member. One component is composed of multiple members, one component is a part of another component, and one component overlaps with another component , And so on. It suffices that the various components are configured so as to realize their functions, and they may be realized by hardware or may be realized by a computer program. For example, a certain component can be realized as dedicated hardware that exhibits a predetermined function, a setting device in which the predetermined function is realized by a computer program, a combination thereof, and the like.

A “graphical user interface” (GUI) means, for example, visualizing by touching one or more of an on-screen icon, image button, pull-down menu, or numeric input window with a cursor or, in the case of a touch panel, An interface that can be operated manually.

“Icons” are (i) those that display predetermined information and can be selected by the operator, and (ii) those that simply display predetermined information and are configured to be selectable. Not included may be included. All or some of the icons displayed on the screen can be selected by touching the respective display locations with a touch pen or the operator's finger, or by a cursor on the screen.

According to the present invention, even in the method of injecting the contrast agent by sucking the contrast agent from the drug solution container, it is possible to inject the drug solution with various contrast agent concentrations without preparing in advance a plurality of types of contrast agents having different concentrations, In addition, it is possible to provide a chemical injection device or the like that can change its concentration with good operability.

It is a perspective view which shows the structural example of a chemical injection device. It is a perspective view showing an injection head and a drug solution syringe attached to it. It is a block diagram of a chemical injection device and an imaging device. It is a figure which shows the chemical|medical solution circuit corresponding to multi-use typically. It is an example of a screen of a graphical user interface (chemical liquid information display). It is an example of a screen of a graphical user interface (display after suction). It is an example of a screen of the graphical user interface (condition setting). It is an example of a screen of the graphical user interface (condition change). It is another example (condition change) of the screen of the graphical user interface.

Hereinafter, a chemical liquid injector according to an embodiment of the present invention will be described with reference to the drawings.

As shown in FIGS. 1 to 3, the chemical liquid injector 100 according to one embodiment of the present invention is connected to the injection head 110 by a cable 102 and an injection head 110 held on the upper part of a movable stand 111 in one example. And a console 150. In this example, the injection head 110 has two

syringes

200A and 200B that are detachably mounted in parallel. The injection head 110 and the console 150 may be wirelessly connected.

In the following description, the

syringes

200A and 200B may be simply referred to as "syringe 200" without distinction. Further, in the following description, description will be given based on one specific form shown in the drawings, but the chemical liquid injector, syringe, and the like can be variously modified other than those described below.

[Syringe and liquid chemical circuit]
Examples of the drug solution filled in the

syringes

200A and 200B (see FIG. 2) include a contrast agent and physiological saline. For example, one syringe 200A may be filled with a contrast agent and the other syringe 200B may be filled with physiological saline. Instead of the physiological saline, another contrast agent different from the contrast agent in the syringe A may be filled.

The syringe 200 has a hollow cylindrical cylinder member 221 and a piston member 222 slidably inserted in the cylinder member 221. The cylinder member 221 may have a cylinder flange 221a formed at the base end thereof and a conduit portion 221b formed at the tip end thereof. By pushing the piston member 222 into the cylinder member 221, the drug solution in the syringe is pushed out to the outside via the conduit portion 221b.

As shown in FIG. 3, with respect to at least one of the syringes 200, a data holding medium 225 may be attached to a part of the cylinder member 221. In the data storage medium 225, information about the syringe (identification information of the syringe, pressure resistance of the syringe, inner diameter of the cylinder member, stroke of the piston member, etc.) and information on the drug solution filled in the syringe (name (for example, product name)) , Component information such as iodine amount, expiration date, drug solution volume, etc.) may be stored. The data storage medium may have a unique ID unique to the tag. The data holding medium may have at least one information selected from the syringe size, the serial number of the syringe, and the drug standardization code. As the data holding medium, for example, a medium such as an RFID (Radio Frequency Identification) tag or an IC tag that can read information by wireless communication can be used. As another example, the code information printed, stamped, or displayed on a display such as a barcode may be read. The position for attaching the data holding medium may be, for example, the outer peripheral surface of the cylinder member, and specifically, may be the vicinity of the cylinder flange 211a on the outer peripheral surface.

Note that the syringe may be a prefilled type that is pre-filled with the drug solution, or may be a suction type in which the drug solution is sucked and used in an empty syringe. In the case of the suction type, information such as a data holding medium may be read from a drug solution container (a bottle in one example) containing a drug solution such as a contrast agent (details below).

In the case of the suction type, for example, a chemical liquid circuit 880 as shown in FIG. 4 may be used, although not limited thereto. The chemical liquid circuit 880 has a first flow path 881a through which the chemical liquid from one syringe 200A flows and a second flow path 881b through which the chemical liquid from the other syringe 200B flows. These flow paths merge at the connector 883. The connector 883 may be, for example, a mixing device having a function of internally generating a swirling flow to mix two chemical solutions. The drug solution from the connector 883 is sent via the third flow path 881c and is sent to the inside of the blood vessel of the subject through the indwelling needle 885 connected to the end thereof.

The chemical liquid circuit 880 may include a multi-use portion 880M that is commonly used for a plurality of subjects a plurality of times and a single-use portion 880S that is detachably connected to the multi-use portion 880M. The single-use portion 880S is a portion that is removed and discarded after the use for one subject is finished.

A flow path 882a through which the chemical solution from the first chemical solution container 890A flows during suction is connected to the middle of the first flow path 881a. Similarly, a flow path 882b through which the chemical solution from the second chemical solution container 890B flows during suction is connected to the middle of the second flow path 881b. In addition to these flow paths, some predetermined one-way valves (not shown) are provided, so that when the piston members of the

syringes

200A and 200B are pulled, the respective

drug solution containers

890A and 890B (hereinafter, (These may be referred to as a drug solution container 890 without distinguishing them), so that a predetermined amount of drug solution is sucked into the syringe as necessary. On the other hand, when the drug solution is pushed out from the

respective syringes

200A and 200B toward the subject side, backflow into the

flow paths

882a and 882b is prevented. Although the specific configuration of the chemical liquid circuit 880 is not particularly limited, for example, one or both of the

flow paths

882a and 882b connected to the

chemical liquid containers

890A and 890B are provided with a detection unit such as an air sensor, and the chemical liquid in the chemical liquid container It is also preferable to have a configuration capable of detecting when there is no longer any.

[Injection head]
As shown in FIG. 2, the injection head 110 has, for example, a housing that extends in the front-rear direction, and two recesses on which the

syringes

200A and 200B are mounted are located on the front end side of the upper surface of the housing. 120a is formed. The concave portion 120a is a portion that functions as a syringe holding portion.

The syringe 200 may be directly attached to the recess 120a, or may be attached via a predetermined syringe adapter. In FIG. 2, the cylinder flange 221 a of each syringe 200 and the

syringe adapters

121 and 122 that hold the vicinity thereof are illustrated as an example. The shape and function of the syringe adapter are not limited to particular ones and may be any one. The housing of the injection head 110 is also provided with a plurality of physical buttons for causing the injection head 110 to perform various operations.

The injection head 110 also has a piston drive mechanism 130 having at least the function of pushing the piston member 222 of the syringe 200, as shown in FIGS. 2 and 3. Two systems are provided for the piston drive mechanism 130, and each mechanism 130 operates independently. The piston drive mechanism 130 may have a function of retracting the piston member 222 in order to suck the liquid medicine into the syringe, for example. The two piston drive mechanisms 130 may be driven simultaneously or at different timings.

Although not shown in detail, the piston drive mechanism 130 is connected to a drive motor (not shown), a motion conversion mechanism (not shown) that converts the rotational output of the drive motor into a linear motion, and the motion conversion mechanism. , And a syringe presser (ram member) for advancing and/or retracting the piston member 222. As such a piston drive mechanism, a known mechanism generally used in a chemical injection device can be used. An actuator other than the motor may be used as the drive source.

The typical operations of the piston drive mechanism are as follows: chemical liquid injection (ram member advance) and chemical liquid suction (ram member retract). In the “chemical solution injection”, the motor is operated according to a predetermined motor control signal to move the ram member forward, thereby performing the chemical solution injection according to the set injection protocol (injection condition). In the "medical solution suction", the motor is operated in accordance with a predetermined control signal to retract the piston member to suck the chemical solution into the syringe. As a mechanism for delivering the drug solution in the drug solution bag or the drug solution bottle to the subject, a drive mechanism such as a tube pump that crushes the tube to send the drug solution may be used instead of the piston drive mechanism.

The piston drive mechanism 130 may have a load cell (not shown) for detecting the force with which the ram member presses the piston member 220. Using the detection result of the load cell, for example, the estimated value of the pressure of the chemical liquid when the chemical liquid is being injected can be obtained. The calculation of the estimated value is performed in consideration of the needle size, the concentration of the drug solution, the injection condition, and the like. Alternatively, instead of using a load cell (not shown), the pressure may be calculated based on the motor current of a drive motor (not shown).

When the syringe is provided with the data holding medium 225, the injection head 110 reads the information in the data holding medium 225 and/or writes the information in the data holding medium 225 as shown in FIG. It may have a writer 145. The reader/writer 145 may be provided in the recess 120a in which the syringe 200 is mounted. The reader/writer 145 may have only the function of reading information from the data holding medium 225.

The injection head 110 may have a control unit 144 for controlling the operations of the piston drive mechanism 130 and the reader/writer 145, as shown in FIG. Further, for example, the storage unit 146 may store the information read from the data holding medium 225. The control unit 144 can be configured as a control circuit including a processor and a memory.

Although the syringe 200 (200A, 200B) is used in the example of FIG. 3, the liquid medicine may be contained in a liquid medicine container (not shown) other than the syringe. The drug solution container may be, for example, a drug solution bag, a drug solution bottle, or the like.

(Data reading means for chemical solution container)
As shown in FIG. 3, a data holding medium 892 may be provided in either or both of the

chemical liquid containers

890A and 890B. The data holding medium 892 may be, for example, an RFID tag or an IC tag, or may be a bar code or the like. The information stored in the data storage medium may be one or a combination of the type of chemical solution, product name, manufacturing company name, expiration date, capacity, concentration, manufacturing number, manufacturing date, and the like. The chemical solution container 890 may be, for example, a chemical solution bottle, a chemical solution bag, or the like, and may have any specific outer shape. The data holding medium 892 may be provided, for example, on a part of the peripheral wall surface of the chemical liquid bottle.

In order to hold the liquid medicine container 890, the liquid medicine injector 100 may be provided with

holders

181A and 181B, as schematically shown in FIG. In this example, the holder 181A and the holder 181B are configured separately, and each holds the chemical liquid container 890. However, the

holders

181A and 181B are integrally configured as one component to form two chemical liquid containers. It may be configured to hold 890A and 890B.

A data reading device 183 may be provided to read the information in the chemical liquid container 890. The data reading device 183 may be, for example, a bar code reader, an IC tag reader, or the like, depending on the type of the data holding medium 892 attached to the drug solution container 890. Of course, other data bearing media and data reading devices 183 may be used. The positional relationship between the data holding medium 892 and the data reading device 183 is not limited, but the data reading device 183 faces the data holding medium 892 with the chemical solution container 890 set at a predetermined position. May be. The information read by the data reading device 183 is referenced by at least one of the injection head 110 and the console 150 of the chemical liquid injector 100.

〔console〕
The console 150 may be placed in an operation room adjacent to the examination room and used, for example. The console 150 includes a display device (display) 151 for displaying a predetermined image, an operation panel 159 provided on the front surface of the housing, a control circuit (details below) arranged in the housing, and the like. The operation panel 159 is a portion on which one or more physical buttons are arranged and is operated by the operator. The display device 151 may be a touch panel display device or a display having only a display function. The console 150 may have a speaker or the like (not shown) for outputting sound and/or voice. Further, another display device may be provided on the injection head.

In the block diagram of FIG. 3, the console 150 is connected to a control unit 155 that controls the operation of each connected unit, an injection processing unit 153, a storage unit 154 that stores various data, and a predetermined external device. And an interface for doing so. The console 150 may have an input device 157 operated by an operator.

The injection processing unit 153 is a part that controls creation of an injection protocol, execution of injection, and the like, and includes, for example, a setting screen display function, an injection protocol creation function, an injection control function, a history generation function, and a history output function. It may be one. Although the injection processing unit 153 is shown separately from the control unit 155 in FIG. 3, the function of the injection processing unit 153 may be provided as a part of the control unit 154.

The setting screen display function may correspond to the function of displaying information for setting the injection protocol, specifically, the GUI for setting the injection protocol on the display device 151. The GUI for setting the infusion protocol may be stored in the drug infusion device, the imaging device, or any other storage device of the computer.

The protocol creation function may correspond to, for example, a function of accepting an input operation on the touch panel or the like of the display device 151 by an operator and creating an injection protocol in which the content is reflected. As the conditions input by the operator in this manner, for example, at least one selected from the type of drug solution, the infusion rate of the drug solution, the injecting amount of the drug solution, the physical information of the patient, the body section of the patient to be imaged, the imaging site, and the like. It may be one.

The injection control function may correspond to the function of controlling the operation of the piston drive mechanism 130 according to the created injection protocol. The injection control function may be a function of operating only one of the piston drive mechanisms 130 and a function of operating both of them simultaneously.

The history generation function may correspond to the function of generating injection history data or suction history data. As the “injection history data”, for example, an injection work ID, which is unique identification information for each injection work, injection start and end dates and times, identification information of a chemical injection device, identification of a chemical liquid and an imaging site which are the injection conditions described above. It may be information or the like. These may be text data. Further, one of the horizontal axis and the vertical axis may be elapsed time and the other may be image data of a temporal graph of the injection speed. The injection history data may be information on the drug solution or information on the syringe acquired from the data holding medium of the syringe, manually input by the operator, or input from an external network or the like. The “suction history data” may include, for example, an injection work ID, which is unique identification information for each injection work, as described above, and may include the date and time when suction was performed, information on suction conditions, information on a liquid medicine container, and liquid medicine. Information, identification information of the chemical injection device, and the like may be included.

The history output function may correspond to the function of transmitting injection history data and the like to the outside. Specifically, the data may be transmitted to a predetermined external device and/or network. Information on the drug solution or syringe information acquired from a data holding medium such as a syringe, acquired from the data holding medium of the drug solution container, manually input by an operator, or input from an external network is used as the drug solution injector. May be transmitted from the hospital to the medical information system in the hospital.

The storage unit 154 may store, for example, an image displayed on the display device 151 or GUI data. Further, an algorithm including a calculation formula for setting the injection condition and/or the suction condition, and the data of the injection protocol may be stored. The injection rate may be constant or may change with time. Information regarding such an injection protocol may be input from an external device connected via an interface. Further, the console 150 may have a slot (not shown), and input may be performed through an external storage medium inserted therein.

[Imaging device]
The imaging apparatus 300 (FIG. 3) is, for example, an X-ray CT scanner, an MRI apparatus, or an angiography apparatus, a PET apparatus, an ultrasonic diagnostic apparatus, and the like, and an imaging unit 303b that captures a fluoroscopic image of a patient and a bed on which the patient is placed. It may have 304 and the control part 303a which controls those operations. The chemical injection device shown in FIGS. 1 and 2 is for CT examination in this example, but a chemical injection device corresponding to the type of the imaging device is appropriately used as the chemical injection device.

〔motion〕
An operation example of the chemical liquid injection system of the present embodiment configured as above will be described below. It should be noted that in the following, only the suction of the contrast agent from the drug solution container 890A is referred to, but it is of course possible to suction the physiological saline from the drug solution container 890B into the syringe 200B in the present invention.

First, set the

chemical liquid containers

890A and 890B in the

holders

181A and 181B, respectively, and connect the

flow paths

882a and 882b of the chemical liquid circuit 880 to the

chemical liquid containers

890A and 890B. The

syringes

200A and 200B are set in the injection head 110. Although not particularly limited, it is assumed that the syringe 200B is already filled with physiological saline and the syringe 200A is empty.

The information of the data holding medium 892 of the drug solution container 890A is read by the data reading device 183 with the drug solution container 890A set in the holder 181A. Note that this reading operation may be automatically performed when, for example, the chemical liquid container 890A is set in the holder 181A.

The console 150 displays the read information on the display device 151 in a screen as shown in FIG. 5, for example. In this example, the chemical liquid information 520 in the chemical liquid container is displayed. Specifically, one or more of the product name of the contrast agent, the concentration of the contrast agent, and the volume (remaining amount) of the contrast agent are displayed. According to the configuration in which the liquid medicine information of the liquid medicine container 890A is read by the device and is displayed in this way, the operator sees the displayed contents and the set liquid medicine container 890A is correct. You can check whether or not.

FIG. 6 is an example of a screen displayed when performing suction from the liquid medicine container 890A to the syringe 200A. In this example, the product name of the contrast agent and the concentration information 513 of the contrast agent are displayed on the screen, and the speed information 521 and the suction amount information 523 are also displayed. Although not limited, the suction may be started by pressing the icon 531 on the screen. It is preferable that the remaining amount of the liquid medicine container 890A is displayed on the screen after the suction is finished. In FIG. 6, the remaining amount display portion 525 displayed in a bottle shape is drawn as an example. .. In this example, since 60 ml was suctioned from the volume that was initially 500 ml, the remaining amount is 440 ml. In this way, according to the configuration in which the remaining amount after suction is displayed, for example, when the chemical liquid container 890A is arranged at a position where it is difficult to visually recognize, or when the chemical liquid container 890A is set in the holder 181A, the container remaining amount is confirmed Even in the case of a structure that makes it difficult to perform, it is preferable because the remaining amount can be confirmed well.

The display device for displaying the information on the drug solution container and/or the drug solution contained therein may be any device other than the console (for example, an injection head). As a specific example, in the configuration in which the drug solution bottle is set in the bottle keeper (holder), it is assumed that the contents such as the label attached to the drug solution bottle cannot be visually recognized when the drug solution bottle is set. On the other hand, according to the configuration of the present embodiment, it is possible to reliably confirm the information regarding the drug solution container and/or the drug solution contained therein.

By displaying information on the drug solution container and/or the drug solution contained in the display device, the remaining capacity can be constantly monitored and the next inspection can be performed manually and/or automatically. It is possible to count the number of times of suction, to replenish (suck) when the required amount is insufficient, to read a set amount, and to suck an appropriate amount. When the remaining amount of the liquid medicine container is less than or equal to a predetermined value, a message such as "Replace the liquid medicine bottle" may be displayed.

Various conditions may be set (for example, injection condition settings) by using the information read from the data storage medium of the drug solution container. According to such a configuration, it is possible to more accurately set the conditions and the like as compared with the case where the operator manually sees the label of the chemical liquid bottle and manually inputs the information read from the label. Become.

FIG. 7A is an example of a graphical user interface for setting an injection protocol. Various types of interfaces have been conventionally proposed as this type of interface, and a detailed description thereof will be omitted because any method may be used, but in FIG. 7A, a human body image 540 simulating a human body is displayed. The human body image 540 includes a plurality of body division icons 540a to 540d, and each body division icon can be selected. For example, when the chest icon 540b is selected, correspondingly set chemical liquid conditions are read and displayed. As an example, in FIG. 7A, the injection protocol display unit 542 displays a condition image 541 including information on the injection speed (5.0 mL/sec) and the injection amount (20 mL).

The screen of FIG. 7A further displays syringe remaining amount information 533, pressure limit information 534, contrast agent concentration information 535, and dilution rate information 536.

The syringe remaining amount information 533 displays that the remaining amount of the syringe A is 150 mL and the remaining amount of the syringe B is 150 mL. The pressure limit information 534 indicates that the pressure resistance of the syringe is 300 psi. The contrast agent concentration information 535 indicates that the iodine amount of the contrast agent is 350 mgI/mL (note that the numerical value of the relevant portion is a value that becomes the reference concentration when setting the conditions, and is actually in the syringe). It may be different from the contained contrast agent concentration). The dilution ratio information 536 indicates that the mixing ratio of the contrast agent and the physiological saline is 1:1 and the dilution ratio is 50.

On the screen of FIG. 7A, the portion of the contrast agent concentration information 535 is an icon that can be selected, and the iodine amount of the contrast agent can be changed by touching this icon. For example, a toggle display in which several concentrations are sequentially switched, such as 350 mgI/mL→300 mgI/mL→240 mgI/mL, may be displayed. As a matter of course, the number of densities displayed as a candidate is not limited to three, and may be appropriately increased or decreased. Instead of the selection method as described above, a ten key (not shown) may be displayed and the numerical value of the density may be input via the ten key. Alternatively, a pull-down menu including a plurality of candidates may be displayed on the screen, and one of them may be selected.

When, for example, 350 mgI/mL is changed to 300 mgI/mL by the above function, in the configuration of the present embodiment, the dilution rate of the drug solution is automatically changed as if the contrast agent of 300 mgI/mL is used. (In this case, the dilution rate is changed from 50% to 40%). In the changed screen, the numerical value of the contrast agent concentration information 535 is changed to "300" and the numerical value of the dilution rate information 536' is changed to "40%" as shown in FIG. 7B.

According to the above configuration, although the contrast agent actually contained in the syringe 200A is 350 mgI/mL, the concentration of the contrast agent (see reference numeral 535) is directly changed to change the dilution ratio (reference numeral 536'). ) Can be used like 300 mgI/mL. Such a mode is particularly useful for a multi-use system in which injection is performed for a plurality of patients without changing the drug solution container 890A.

Even when the contrast agent concentration is changed as in the state of the screen of FIG. 7B, the concentration information 513 of the contrast agent actually filled in the syringe may continue to be displayed on the screen. In terms of form, it is preferable. By doing so, it is possible to confirm both the actual contrast agent concentration (350 mgI/mL in this example) and the changed contrast agent concentration (300 mgI/mL in this example) on one screen.

After the completion of the injection protocol setting, the chemical solution injection is started when the operator inputs one or more predetermined inputs. Various conventionally known methods can be used for the procedure up to the start of the chemical injection, the operation of the piston drive mechanism 130 during the injection of the chemical, and the like.

As described above, according to the drug solution injector of the present embodiment, the drug solution is injected by sucking the contrast agent or the like from the drug solution container 890 into the syringe 200, but the contrast agent concentration is changed on the graphical user interface. It is possible, and the dilution rate is automatically changed accordingly, and the chemical solution having a desired concentration is injected, so that it is not necessary to prepare a plurality of types of contrast agents having different concentrations in advance.

In the configuration in which the drug solution is sucked from the drug solution bottle (one example) as in the above-described embodiment, the drug solution bottle containing 500 mL of the contrast agent of 350 mgI/mL is temporarily removed after using only 100 mL, and the drug solution bottle of 350 mgI/mL is removed. If it is to be set again, such work is not preferable from the viewpoint of labor of work, keeping clean of the chemical solution, and the like. Particularly, in the case of a device for heating a chemical bottle, it is necessary to reheat the bottle. On the other hand, according to the configuration of the present embodiment, it is possible to inject a contrast agent having a desired concentration without replacing the drug solution container 890.

Although the present invention has been described above with reference to specific examples, the present invention can be appropriately modified without departing from the spirit of the present invention:
-For example, with respect to the screen shown as an example of the graphical user interface, not all display elements in the screen are essential, and the display elements may be increased or decreased as appropriate.
The content of the graphical user interface is not necessarily displayed at one unit or at one place, and may be configured to be displayed at a plurality of units or at multiple places as necessary.

In the above-described embodiment, an example in which a plurality of syringes are held by the injection head has been described, but as one embodiment of the present invention, the first drug solution (for example, contrast agent) and the second drug solution can be stored in one syringe from the drug solution container. The medical solution (for example, physiological saline) may be drawn in by a predetermined amount to prepare a medical solution having a desired concentration. The injection head may be of single-cylinder type or multi-cylinder type.

(Specific example of GUI)
Although various changes can be made to the graphical user interface, for example, the condition image 541 shown in FIG. 7A or the like may be more specifically as shown in FIG. In the example of FIG. 8, the injection speed (5.0 mL/sec) and the injection amount (80 mL) of the mixed drug solution are displayed, and the

injection condition displays

547a and 547b of the contrast agent and the physiological saline are displayed. ing. For example, the injection condition display 547a is displayed as 3.0 mL/sec and 50 mL, and the injection condition display 547b is displayed as 2.0 mL/sec and 30 mL (the displayed numerical values are merely examples).

The condition image 541 may function not only as a display of setting conditions but also as a user interface that receives an input for starting a predetermined operation. For example, the image portion 543 showing the injection amount of the contrast agent is an icon, and when the user touches the icon portion (or with the accompanying predetermined input from the operator), the suction operation into the syringe is performed. It may be started. Of course, the physiological saline may have the same user interface.

(Example of display mode related to contrast agent concentration information)
7A and 7B show an example in which two pieces of information, that is, the concentration information 513 of the contrast agent in the actual liquid medicine container and the contrast agent concentration information 535 that is information that can be used for setting the conditions are displayed on the screen. In this regard, the liquid injector may be configured as follows:
As described above, a plurality of options (for example, 350 mgI/mL, 300 mgI/mL, 240 mgI/mL) can be displayed as the contrast agent concentration information 535, but regarding this display, the actual contrast agent concentration (reference numeral 513) is used. Also, the high concentration option may be configured not to be displayed. For example, if 300 mgI/mL is used, the 350 mgI/mL option will not be displayed. With such a display mode, it becomes more convenient. Similarly, the configuration may be such that an option (value) having a higher concentration than the actual contrast agent concentration cannot be input, and when such an option (value) is input, a notification is given. Operations such as recording information and/or transmitting data to a predetermined external device may be performed.

Further, even if the chemical liquid injector is configured to compare the actual contrast agent concentration (reference numeral 513) with the contrast agent concentration (reference numeral 535) for condition setting, and perform predetermined control according to the result. Good. For example, the predetermined light emitting device of the chemical liquid injector and the predetermined display on the screen may be different depending on whether they are the same or different. Specifically, when the two are the same, the display on the screen with the first color, the first light emission pattern, and/or the first shape (in one example, the contrast agent concentration information 535 and the dilution rate information 536) is displayed. If they are different, they may be represented by the second color, the second light emission pattern, and/or the second shape when different.

(Appendix)
This application discloses the following inventions:
1. An injection that holds the first syringe (200A) filled with the first chemical liquid and the second syringe (200B) filled with the second chemical liquid, and mixes the first and second chemical liquids and can inject the mixture. A head (110),
A control unit (150, 155) that provides a graphical user interface for setting a drug infusion protocol;
Equipped with
At least with respect to the first drug solution, a drug solution injector for sucking the first drug solution from the drug solution container (890) into the first syringe (200),
The control unit (150, 155) is
A process of displaying information (513) on the concentration of the contrast medium, which is the first chemical liquid, and information (536) on the mixing condition of the first and second chemical liquids,
A process of accepting a change in the concentration of the contrast agent (350 mgI→300 mgI),
A process of changing the mixing condition of the first and second chemical solutions corresponding to the changed contrast agent concentration and displaying information (536') regarding the changed mixing condition;
A chemical injection device configured to perform.

2. The chemical liquid injector according to the above, wherein the information regarding the mixing condition is a dilution rate.

3. further,
The chemical injection device according to the above, further comprising a data reading unit (183) for reading information of a data holding medium attached to the chemical container (890). This unit may perform data writing.

4. The chemical injection device as described above, wherein the data holding medium is an IC tag.

5. The control unit performs a process of displaying information on at least one of the suction amount (523) and the remaining amount of the liquid medicine (525) in the liquid medicine container when the liquid medicine is sucked from the liquid medicine container (890). The chemical injection device described above.

6. A chemical solution injection system comprising the chemical solution injection device described above and a chemical solution circuit (880) connected to the first and second syringes.

7. The chemical circuit is
A multi-use part (880M) including at least a flow path connected to the first syringe and a flow path connected to the second syringe, the multi-use part (880M) being used a plurality of times for examination on a plurality of subjects;
A single-use part (880S) that is detachably connected to the multi-use part and is exchanged for each subject.
Including
The chemical injection system described above.

7. Furthermore, the chemical liquid injection system as described above, comprising a chemical liquid bottle as the chemical liquid container.

A1. An injection head capable of holding a first drug solution container filled with a first drug solution and a second drug solution container filled with a second drug solution, and mixing and injecting the first drug solution and the second drug solution. ,
A control unit that provides a graphical user interface for setting a drug injection protocol;
Equipped with
At least with respect to the first drug solution, a drug solution injector for sucking the first drug solution into the first syringe from a drug solution container,
The control unit is
A process of displaying information about the concentration of the contrast agent, which is the first drug solution, and information about the mixing condition of the first and second drug solutions;
A process of accepting a change in the concentration of the contrast agent,
A process of changing the mixing condition of the first and second chemical solutions corresponding to the changed contrast agent concentration and displaying information on the changed mixing condition;
A chemical injection device configured to perform.

The present application also discloses that the technical idea of the above invention is expressed as a control method invention and a computer program invention. The reference numerals in parentheses described above do not limit the present invention.

100 chemical injection device 110 injection head 130 piston drive mechanism 150 console 151 display device 200 (200A, 200B) syringe 221 cylinder member 222 piston member 225 data holding medium 300 image pickup device 880 chemical liquid circuit 880M multi-use part 880S single-

use part

881a, 881b , 881c Flow path 883 Connector 885 Indwelling needle 890 (890A, 890B) Chemical solution container 892 Data holding medium

Claims

An injection head that holds a first syringe filled with a first drug solution and a second syringe filled with a second drug solution, and is capable of mixing and injecting the first and second drug solutions,
A control unit that provides a graphical user interface for setting a drug injection protocol;
Equipped with
At least with respect to the first drug solution, a drug solution injector for sucking the first drug solution into the first syringe from a drug solution container,
The control unit is
A process of displaying information about the concentration of the contrast agent, which is the first drug solution, and information about the mixing condition of the first and second drug solutions;
A process of accepting a change in the concentration of the contrast agent,
A process of changing the mixing condition of the first and second chemical solutions corresponding to the changed contrast agent concentration and displaying information on the changed mixing condition;
A chemical injection device configured to perform.
The chemical injection device according to claim 1, wherein the information regarding the mixing condition is a dilution rate.
further,
A data reading unit for reading information of a data holding medium attached to the liquid medicine container,
The chemical injection device according to claim 1 or 2.
The chemical injection device according to any one of claims 1 to 3, wherein the data holding medium is an IC tag.
The control unit
When the liquid medicine is sucked from the liquid medicine container,
Perform processing for displaying information on at least one of the suction amount and the remaining amount of the liquid medicine in the liquid medicine container,
The chemical injection device according to any one of claims 1 to 4.
A liquid injector according to any one of claims 1 to 5,
A liquid chemical circuit connected to the first and second syringes;
A liquid chemical injection system including.
The chemical circuit is
A multi-use part including at least a flow path connected to the first syringe and a flow path connected to a second syringe, the multi-use part being used a plurality of times for examination on a plurality of subjects;
A single-use part that is detachably connected to the multi-use part and is exchanged for each subject,
Including
The chemical injection system according to claim 6.
further,
The drug solution container includes a drug solution bottle,
The chemical liquid injection system according to claim 6 or 7.
A computer that provides a graphical user interface for setting the drug injection protocol.
A process of displaying information about the concentration of the contrast agent, which is the first drug solution, and information about the mixing condition of the first and second drug solutions on the display;
A process of accepting a change in the concentration of the contrast agent,
A process of changing the mixing condition of the first and second chemical solutions corresponding to the changed contrast agent concentration and displaying information on the changed mixing condition;
A computer program that causes a computer to execute.
A method for controlling a computer that provides a graphical user interface for setting a drug injection protocol, comprising:
A step of causing a computer to display information regarding a concentration of a contrast agent which is a first chemical solution and information regarding a mixing condition of the first and second chemical solutions on a display;
A computer receiving a change in the concentration of the contrast agent,
A step in which the computer changes the mixing condition of the first and second chemical solutions corresponding to the changed contrast agent concentration, and displays information regarding the changed mixing condition;
Including a control method.