WO2020080871A2 - Biomarker composition for determining cancer drug responsiveness, method for determining cancer drug responsiveness using biomarker composition, and diagnostic chip for detecting biomarker composition for determining cancer drug responsiveness - Google Patents

Abstract

The present invention relates to a biomarker composition for determining the responsiveness of a discovered cancer drug by using genetic biomarker labeling scan (GBLscan), which is a drug indication and responsiveness prediction system and method, as a new learning model capable of reliably predicting the responsiveness of a drug by performing coupling analysis on a molecular profile of the drug after transforming specific genetic variation fingerprints related to diseases including cancer into a haplotype having functional information, a method for determining cancer drug responsiveness using the biomarker composition, and a diagnostic chip for detecting a biomarker composition for determining cancer drug responsiveness.

Description

Biomarker composition for determining cancer drug responsiveness, method for determining cancer drug reactivity using biomarker composition, and diagnostic chip for detecting biomarker composition for cancer drug reactivity determination

The present invention predicts a haplotype biomarker including cancer drug reactivity and gene expression information and functional information using copy number variation (CNV), so that cancer drug responsiveness can be predicted reliably and drug labeling can be performed. Biomarker composition for determining cancer drug responsiveness discovered using a new learning model, GBLscan (Cancer Biomarker Labeling Scan), method for determining cancer drug responsiveness using biomarker composition, and diagnosis for detecting biomarker composition for cancer drug responsiveness determination It's about the chip.

Recent advances in next-generation sequencing (NGS) technology have made many advances in understanding complex and diverse cancers. In addition, an international consortium effort has developed and published a catalog of somatic mutations in these cancer species as well as a comprehensive database of cancer mutations.

The results of this international consortium study have also led to a rapid growth in cancer-specific treatment for specific genomic fingerprints of individual tumors.

However, new customized cancer treatments that are clinically approved and used are still insufficient for all stakeholders in the medical world, including cancer patients and the pharmaceutical industry. Therefore, there is a need for an efficient and systematic approach to predicting the association for personalization between genomic information and the response of anticancer drugs.

In addition, several collaborative consortia have been established to integrate molecular profiling data from cancer cell lines and drug toxicity data [www.lincsproject.org]. The consortium's most important goal is to identify genomic biomarkers that can predict anti-cancer drug toxicity and personalized drugs.

Among the cell line genome DBs for drug toxicity in cancer, GDSC (Gnomics of Drug Sensitivity in Cancer) is one example of a publicly available database. In particular, GDSC is a public database that experimentally measures drug toxicity information of 1,070 human cancer cells against 265 anti-cancer compounds.

The GDSC cell line project used here was published at the following site (CCLP: COSMIC Cell Lines Project, http://cancer.sanger.ac.uk/cell_lines). It is expected that these common resources will help in realizing genome-based precision cancer treatment.

However, despite the potential value of these databases, due to the high level of data and complexity, there are many technical problems with integrated analysis. Thus, although many computational methods have been developed to systematically characterize molecular biomarkers in anticancer drug toxicity, despite these efforts, drug toxicity is limited to a specific cell line and a given set of genetic variations, all of which have different genetic information. This is because the common variation is only part of the whole.

With the recent advancement in information technology, a method increasingly used to solve the aforementioned complex problem is called a deep learning model or a deep learning model. Deep learning learning method is a field of deep machine learning from a large amount of high-dimensional raw data.

Until recently, there were many limitations directly to the amount of computation to train, but you can train deep learning learning models with various layers containing thousands of hidden units while using methodological improvements and powerful machines with parallel computing. It became.

On the other hand, since it is possible to manipulate various types of structural information such as pharmacological, genomic, transcript and epigenetic data, and their drug reactivity data, it is suitable for predicting drug-target interaction with minimal guidance.

The pharmaceutical industry is beginning to show great expectations for deep learning learning that uses this type of data to develop new drugs. In recent years, some promising results have been demonstrated using artificial intelligence in drug development, and drug repositioning with superior predictive accuracy compared to drug-target profiles and other traditional machine learning models is also possible. However, the majority of approaches are more than just proof of concept, and a solution capable of producing drugs through deep learning is insufficient.

Currently, PubChem (pubchem.ncbi.nlm.nih.gov) is operated by the National Institute of Technology Information (NCBI) in the United States and provides information on about 100 million compounds, 200 million substances, and bioassay information. (En.wikipedia.org/wiki/PubChem).

In addition, there are many methods for expressing this compound as a pharmacophore descriptor. Among them, the Padel method can be expressed in 1875 (1D and 2D 1,444, and 3D 431) features and 12 fingerprints (about 16,092 bits in total) in the drug.

And the variation in genome can extract various features. In particular, conventional methods for extracting a disease-causing mutation have been disclosed in various documents.

Therefore, in the prior art, QSAR (Quantitative structure activity relationship), drug development using drug cytotoxicity data, deep learning-based expression regulation of whole genome sequencing, structural variation, etc. are independently applied and utilized. Became.

In the present invention, however, CDR drug (Cancer drug response scanning), an AI deep learning method that integrates heterogeneous characteristic information (dielectric information, QSAR information, and expression information) into drug-cell lines-toxicity (IC50) data, Prediction accuracy has been significantly improved compared to previous computer modeling approaches, especially virtual drugs vs. We have proposed a model for the interaction of virtual cells (cell lines) or target proteins.

Here, in the case where the first is a drug as two different heterogeneous virtual information, a Padel method may be applied.

And the second can be described as a literature method for the genomic fingerprint (or a set of mutation features) of the full-length genome (or target protein), and is the most standard deep learning method.

Therefore, the method can be used in an accurate drug response prediction model and drug re-use / drug repositioning, screening of chemicals, discovering new anticancer drug candidates, and a clinical decision supporting system for selecting patient-specific anticancer drugs. .

In addition, a recent article on cancer drug reaction scan (CDRscan) related to drug repositioning was published by the head office.

That is, a drug responsiveness study using expression information and biomarker information of drugs, target gene drugs, and target candidate genes given by gene expression and system statistical methods has recently been published.

Although there has been no research on the biomarker itself in this paper, the inhibition of the major drugs against major targets by using known gene biomarkers and expression information is inhibited by CCLE (Cancer Cell Line Encyclopedia), CTRP (Cancer Therapeutics) Response Portal, Broad) and some GDSCs were used to predict (CARE) and verify the results.

In addition, a number of major studies have been published on expression and Quantitative Trait Loci (eQTL), a disease or phenotypic link between expression and genomic variation. In addition, a number of major studies have been published on the disease and phenotypic linkage between protein production and genomic variation, i.e., protein and Quantitative Trait Loci.

However, studies on the relationship between drug response or drug phenotype between cQTL (Copy Number Variation and Quantitative Trait Loci), that is, copy number variation (CVV), which is an increase or decrease variation in drug responsiveness and gene copy number, and genomic variation, have not been published. none.

Therefore, in this method of genetic biomarker label scan (GBLscan), (a) eQTL (expression and Quantitative Trait Loci), that is, disease or phenotypic relationship between expression and genomic variation, (b) cQTL (Copy Number Variation and Quantitative Trait Loci), In other words, no reference exists for the relationship between copy amplification and copy deletion.

In the present invention, the definition of the drug type (DrugClass) is a type of drug targets and a functionally similar functional type of drug, or a gene group, drug pathway or drug signaling of a category in which the drug is affected. Pathway (drug signaling pathway), etc. are all described as one generic drug type (DrugClass). In addition, unlike the haplotypes of several locus that have been phasing in the gene, which is a commonly used haplotype, the functional subflow type is a human genome version of Dec. 2013 (GRCh38 / hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https: sorting the next-generation sequencing read (read) data based on the //www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 When done, information is read in genotype form at each gene locus. This type of genotype is expressed in the form of 1: homo, 2: hetero, or 3: alt home, and such a collection of genotypes can be called a relative halfrotype. And if the relative haplotype composed of a single or a combination of specific locus is related to the expression of a specific gene, it is defined in the present invention as a functional hypoprotype.

The present invention has been devised to solve the above-described conventional problems, and the present invention has the genetic properties and fingerprints of functional genomes of the target genomes that respond to cancer drug reactivity according to the technical background and social needs as described above. To provide a high-accuracy drug indication and sensitivity prediction system by converting to a haplotype, a specific object of the present invention is known non-clinical cell line genomes, their gene expression information and gene duplication, and in vivo It is to provide a prediction system that can reliably predict the information-based linear regression modeling and deep learning machine learning with a collection of quantitative trait loci (QTL) related to drug response.

And in the present invention, the GBLscan method according to the present invention collects quantitative trait positions (QTL) that have high correlation with gene RNA expression and copy number variation (CNV) to generate multivariate-based haplotypes with functional information and drugs It is to provide a method for predicting drug reactivity for a virtual clinical trial (In Silico Clinical Trial) that effectively filters sensitivity and reactivity.

According to a feature of the present invention for achieving the object as described above, the present invention comprises the steps of generating a collection of positions of the quantitative target location (QTL) to be inspected; Calculating a functional response type (FRH) and a drug response correlation; And, it consists of the step of generating a functional haplotype-based drug response prediction model.

 First, in a first step for generating a location collection of quantitative features (QTLs); To perform a function-related haplotype (FRH) and drug-reactivity correlation calculation, (A) calculate about 4 million mutations and about 20,000 gene expression correlations in about 1,000 cell lines, and (B) drugs (265) ) And correlation between each 20,000 gene expression and gene replication variants of 1,000 cell line genomes.

At this time, steps (A) and (B) include both gene expression and gene copy number variations as common variables, and these common variables, gene expression information, are used to correlate with multiple or single mutations that affect drug responses. Collect the mutations you have. This is called a collection of quantitative trait locations (QTLs).

Then, a single and multiple mutation information is collected from each cell line genome in the genome-integrated DB to create functional haplotypes, extracted with drug reactivity information from the same cell line, and these functional haplotypes are functional haplotypes, FRH (Functionally relevant haplotope) ), And the FRH is expressed as a hash number.

  Then, in the second step, in order to calculate the correlation between the functional Haflow type (FRH) and the drug response, the Haflow type (FRH) is changed to a hash number, and the converted drug hash number is used to convert the drug reactivity information. The Pairwise Pearson Test is performed and the above operation is repeated for all carcinomas.

  In the third step of generating a functional hypoflow type-based drug response prediction model, a process related to generating a drug pathway-based drug response prediction model in a specific cancer is performed as follows.

(1) Calculate the correlation with each drug related to the function-related haplotype and specific cancer and drug pathway, and (2) X-axis and Y-axis in the functional haplotype and drug-reactivity correlation metrics. Cluster the correlation information, (3) collect the high significance (p-value) from each prediction model, apply the interaction function to the model to calculate the linear regression model, and finally (4) Using NGS data as inputs, we calculate the functional subflow type related to drug reactivity and predict the drug reactivity using a linear regression model.

And the present invention, to calculate the drug reactivity prediction model using the functional haflow type information as described above, using a number of variations in the base sequence collected from the genome to be tested to calculate the functional haflow type and : Calculating a solution of the linear regression model; A system for screening cancer drugs with high sensitivity among cancer drugs using such a solution is included.

On the other hand, explaining one of the various embodiments of the present invention, the present invention comprises the steps of: (A) calculating the positional collection of quantitative trait positions (QTLs) for variations affecting the drug response; (B) generating a functional subflow type for the variation included in the quantitative trait position (QTL); (C) calculating a correlation between a mutation and a drug response based on the functional subflow type; And (D) predicting drug responsiveness based on the functional subflow type.

In this case, calculating the positional collection of the quantitative trait positions (QTL) in the step (A) includes: (A1) deriving a correlation between mutations and gene RNA expression from a plurality of cell lines; (A2) deriving a correlation between drugs and gene RNA expression and gene copy number variation (CNV) contained in a plurality of cell line genomes; (A3) calculating gene expression information for gene RNA expression or gene duplication mutation, which commonly affects correlation in steps (A1) and (A2); And (A4) calculating a single or multiple mutations involved in the gene expression information to calculate a quantitative trait position (QTL) for mutations affecting the drug response. It can be performed, including the step of generating a collection of locations.

In addition, the generation of the functional subflow type in the step (B) may be generated by extracting the subflow type for a single or multiple mutations included in the quantitative trait position (QTL) from the genome integration DB together with the drug reactivity.

In addition, the functional underflow type includes correlation information between gene RNA expression (Exp) and drug responsiveness; It may also be configured to include information on the correlation between gene multiplex (loci) and drug responsiveness.

On the other hand, the functional subflow type, correlation information between the gene replication mutation (CNV) and drug response; It may also be configured to include information on the correlation between gene multiplex (loci) and drug responsiveness.

Here, the gene multivariate (loci) may be a collection of locus selected based on quantitative trait location (QTL).

In addition, the dielectric integration DB may be a Cell Lines integrated DB composed of a genotype.

In addition, the drug reactivity may be expressed by an ln Ic50 value.

In addition, the gene RNA expression may be divided into over-expression, normal, and under-exprfession.

In addition, the copy number variation (CNV) may be divided into amplification (amplification), no change (normal), and reduction (deletion).

On the other hand, the correlation calculation of the step (C) comprises: (C1) determining the gene RNA expression (Exp) associated with the gene multivariate (loci); (C2) calculating drug reactivity to the gene RNA expression (Exp) from the functional subtype to determine drug reactivity to the gene multivariate (loci); And (C3) comparing and verifying the drug responsiveness calculated from the correlation information between the gene multivariate (loci) included in the functional subflow type and the drug responsiveness and the drug responsiveness determined in step (C2). It may be carried out.

In addition, the association of the step (C1) may be performed by determining a cell line containing the gene multivariate (loci) and gene RNA expression (Exp) information included in the cell line.

In addition, predicting the drug reactivity of the step (D), when the difference in drug response to the difference in gene RNA expression is greater than the overexpression, it is determined that the low expression of gene RNA is sensitive to the drug reaction; When the difference in drug response to the difference in gene RNA expression is less than the overexpression, it may be determined that the overexpression of the gene RNA is sensitive to the drug reaction.

And predicting the drug reactivity of the step (D), the difference value of the absolute value of the absolute value of the drug response to the difference in gene RNA expression in the overexpression group is the highest value of the absolute value of the drug response sensitivity to the difference in the gene RNA expression of the low expression group. If it is greater than the difference value, it is determined that the overexpression of the gene RNA is associated with the gene multivariate (loci) type; If the difference value of the absolute value sensitivity of the drug response to the difference in gene RNA expression of the overexpression group is less than the difference value of the absolute value of the drug response absolute value of the difference of the gene RNA expression of the difference in gene RNA expression of the overexpression group, the low expression of gene RNA is gene multiplexed. It can also be determined to be associated with a loci type.

Meanwhile, the functional underflow type may be expressed as a hash number.

In addition, the correlation between the functional hypoflow type and the drug reaction may be calculated by performing a drug-reactivity information and a pairwise correlation test (Pairwise Pearson Test) using a hash number.

On the other hand, the present invention includes a drug-reaction type using a drug responsiveness, gene expression information, and copy number variation to generate a functional subtype in the same manner as described above.

At this time, the functional subflow type may be used for diagnosis of responsiveness to drugs, discovery of biomarkers for companion diagnosis to select patient groups for drugs, discovery of drug targets, or virtual clinical trials for drugs.

The following effects can be expected in the functional haplotype system and method using cancer drug reactivity, linked gene expression information, and copy number variation for a virtual clinical trial according to the present invention as described above.

That is, in the present invention, there is an effect capable of predicting the degree of reactivity of a drug whose pharmacological effect is unknown, from results of reactivity of known drugs to in vivo, in vitro or genetic information.

In addition, the present invention can derive the reactivity correlation of the pharmacological functional group constituting the drug to the variation information of the genome, and thus, if the variation of the genome to be analyzed and the pharmacological functional group of the drug are extracted, the degree of reactivity of the drug to the genome is determined It has an effect that can be reliably predicted.

In addition, since the present invention can derive a drug type reactivity correlation with the genome variation characteristic information, knowing the characteristic information and the drug type information about the variation of the genome to be analyzed, the degree of reactivity of the drug to the genome can be reliably determined. It has a predictable effect.

Through this, the present invention can predict the reactivity to a cell line or a human body containing a specific genome of an unknown polymer compound (substance to be developed for drug) before a clinical trial, and thus can significantly reduce the time and cost of developing a new drug. In addition, even for drugs that have already been developed, the degree of reactivity to genomes other than those found in clinical trials can be predicted in advance, thereby significantly reducing the research cost and time for discovering other uses for drugs and finding side effects. There is.

Figure 1 is an exemplary diagram showing a quantitative trait location (QTL), genetic replication number variation and RNA expression examples for the drug response prediction according to the present invention.

Figure 2 is an exemplary view showing a drug response calculation scheme using a genetic biomarker according to the present invention.

Figure 3 is an exemplary view showing the relationship between the genetic biomarker of breast cancer and drug response according to the present invention.

Figure 4 is an exemplary diagram showing the NGS input and drug reaction and RNA expression network according to the present invention.

Figure 5 is an exemplary view showing the correlation of the cell line drug response value (IC50) and functional hypoflow type according to the present invention.

Figure 6 is an exemplary view showing a correlation between the quantitative trait location (QTL) and the drug response according to the present invention.

Figure 7 is an exemplary diagram showing a variation, RNA expression, gene replication number variation and drug response network according to the present invention.

8 is an exemplary diagram showing an example of cell line, cancer, drug response, RNA expression and CNV amplification correlated with mutation according to the present invention.

9 is an exemplary diagram showing a functional hypoflow type and a drug reactivity correlation calculation schema according to the present invention.

Figure 10 is an exemplary view showing a functional haplotype and drug-responsive network according to the present invention.

Figure 11 is an exemplary diagram showing an example of functional subflow type and gene expression and gene replication variation according to the present invention.

12 is an exemplary view showing a functional underflow type definition according to the present invention.

13 is an exemplary view showing an example of FRH method and gene expression and drug reactivity prediction according to the present invention.

14 is an exemplary view showing an example in which the difference in average IC50 values is 1.0 as an example of FRH according to the present invention.

15 is an exemplary view showing an example in which the difference in average IC50 values is 1.5 as an example of FRH according to the present invention.

16 is an exemplary view showing a functional subflow type and gene expression embodiment according to the present invention.

17 is an exemplary view showing a specific cancer drug pathway-based drug response prediction model generation example according to the present invention.

Figure 18 is an exemplary diagram showing the relationship between functional reactivity and drug reactivity R ^ 2 according to the present invention.

FIG. 19 is an exemplary view showing an embodiment of FRH having high FRH correlation with Afatinib drug in the example shown in FIG. 18.

20 is an exemplary view showing an embodiment of a prediction model using FRH having a high FRH correlation with Afatinib drug in the example shown in FIG. 18.

21 is an exemplary view showing an embodiment of predicting drug response of blood cancer using FRH according to the present invention.

22 is an exemplary view showing an example of an available system using FRH according to the present invention.

23 is an exemplary view showing an example of a method of manufacturing a cancer and drug companion diagnostic chip using the FRH biomarker according to the present invention.

24 is an exemplary view illustrating a configuration of a biomarker expression structure according to the present invention.

FIG. 25 is a graph showing correlation values (P-vlaue) values of major biomarkers for blood cancer drugs.

26 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and blood cancer drugs.

27 is a graph showing the correlation (P-vlaue) values for female cancer drugs of major biomarkers.

28 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and female cancer drugs.

Figure 29 is a graph showing the correlation (P-vlaue) values for brain tumor drugs of major biomarkers.

30 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and brain tumor drugs.

Figure 31 is a graph showing the correlation (P-vlaue) values for the head and neck cancer drugs of the major biomarkers.

FIG. 32 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and head and neck cancer drugs.

Figure 33 is a graph showing the correlation (P-vlaue) values for lung cancer drugs of major biomarkers.

FIG. 34 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and lung cancer drugs.

35 is a graph showing correlation values (P-vlaue) of sarcoma cancer drugs of major biomarkers.

36 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and sarcoma cancer drugs.

37 is a graph showing the correlation (P-vlaue) values of ABL drugs of major biomarkers.

Figure 38 is a graph showing the correlation (P-vlaue) values for CHROMATIN drugs of major biomarkers.

39 is a graph showing correlation values (P-vlaue) of EGRF drugs of major biomarkers.

Figure 40 is a graph showing the correlation (P-vlaue) values for the ERK_MAPK drugs of major biomarkers.

FIG. 41 is a graph showing the correlation (P-vlaue) values for IGFR drugs of major biomarkers.

Figure 42 is a graph showing the correlation (P-vlaue) values of the major biomarkers for MITOSIS drugs.

In a preferred embodiment of the present invention, in order to determine responsiveness to a blood cancer drug, a biomarker composition composed of a combination of markers containing a mutation that modulates gene expression, wherein the biomarker composition is 13_37746458_AA_A (Marker 1) , 16_46710765_T_A (marker 2), 11_63382198_CA_C (marker 3), 14_68477626_CT_C (marker 4) and 7_151221500_CT_C (marker 5).

In addition, the biomarker composition may further include any one or more markers among markers described in Table 21 below.

In this case, the blood cancer may include any one or more of ALL (Acute lymphoblastic leukemia), LAML (Acute Myeloid Leukemia) or LCML (Chronic Myelogenous Leukemia).

In addition, the present invention is a method for determining reactivity to a blood cancer drug by detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression, in order to determine reactivity to a blood cancer drug, wherein Biomarker composition, 13_37746458_AA_A (marker 1), 16_46710765_T_A (marker 2), 11_63382198_CA_C (marker 3), 14_68477626_CT_C (marker 4) and 7_151221500_CT_C (marker 5) using a blood marker drug reactivity determination method comprising a biomarker composition It includes.

At this time, the bio-marker composition may be configured to further include any one or more of the markers described in [Table 21].

In addition, the present invention, in order to determine the responsiveness to blood cancer drugs, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing mutations that regulate gene expression, the biomarker composition, which is the target of detection, , 13_37746458_AA_A (marker 1), 16_46710765_T_A (marker 2), 11_63382198_CA_C (marker 3), 14_68477626_CT_C (marker 4) and 7_151221500_CT_C (marker 5) diagnostic chip for detecting biomarker drug reactivity In this case, the biomarker composition may further include any one or more markers among the markers described in Table 21 below.

On the other hand, a preferred embodiment of the present invention, in order to determine the responsiveness to female cancer drugs, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 1_13248174_T_C (marker 1), 16_85071785_A_G (marker 2) and 9_34371054_A_C (marker 3) comprises a biomarker composition for determining the reactivity of female cancer drugs, wherein the biomarker composition, any one of the markers listed in Table 22 It may be configured to further include the above markers.

In addition, the present invention is a method for determining the reactivity to a female cancer drug by detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression in order to determine the reactivity to a female cancer drug, The biomarker composition includes a method for determining female cancer drug reactivity using a biomarker composition comprising 1_13248174_T_C (marker 1), 16_85071785_A_G (marker 2), and 9_34371054_A_C (marker 3), wherein the biomarker composition is , It may be configured to further include any one or more of the markers listed in Table 22.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining reactivity to a female cancer drug, wherein the biomarker composition is 1_13248174_T_C (Marker 1), 16_85071785_A_G (marker 2) and 9_34371054_A_C (marker 3) comprising a diagnostic chip for detecting a biomarker composition for determining drug responsiveness to cancer, wherein the biomarker composition is shown in Table 22 It may be configured to further include any one or more of the markers described.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the brain tumor drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 11_12162199_T_G (Marker 1 ), 13_113159942_A_G (Marker 2), 5_181155466_T_G (Marker 3), 11_65547388_T_G (Marker 4), 10_11921140_T_G (Marker 5), 17_55774876_T_G (Marker 6), 12_40313960_G_T (Marker 7), 12_40313960_G_T (Marker 7), 16_8_T It includes a biomarker composition for determining brain tumor drug reactivity, including, wherein, the biomarker composition may be configured to further include any one or more of the markers listed in Table 23.

In addition, the present invention, in order to determine the reactivity to a brain tumor drug, in a method of determining a biomarker composition composed of a combination of markers containing a variation that controls gene expression, to determine the reactivity to a brain tumor drug, the bio Marker compositions are: 11_12162199_T_G (marker 1), 13_113159942_A_G (marker 2), 5_181155466_T_G (marker 3), 11_65547388_T_G (marker 4), 10_11921140_T_G (marker 5), 17_55774876_T_G (marker 6), 16_8_13 ) And 2_113934259_C_T (marker 9), comprising a method for determining brain tumor drug reactivity using a biomarker composition, wherein the biomarker composition further comprises any one or more of the markers listed in Table 23. It may be.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining reactivity to a brain tumor drug, wherein the biomarker composition is 11_12162199_T_G ( Marker 1), 13_113159942_A_G (marker 2), 5_181155466_T_G (marker 3), 11_65547388_T_G (marker 4), 10_11921140_T_G (marker 5), 17_55774876_T_G (marker 6), 12_40313960_G_T (marker 7) ) Comprises a diagnostic chip for detecting biomarker compositions for determining brain tumor drug responsiveness, wherein the biomarker composition may further include any one or more of the markers listed in Table 23. .

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the head and neck cancer drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 14_21082261_T_G (marker 1) and 7_140753336_A_T (marker 2) comprises a biomarker composition for determining head and neck cancer drug reactivity, wherein the biomarker composition further comprises any one or more of the markers listed in Table 24 It may be configured.

In addition, the present invention is a method for determining reactivity to a head and neck cancer drug by detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression in order to determine the reactivity to the head and neck cancer drug. The biomarker composition includes a method for determining head and neck cancer drug reactivity using a biomarker composition comprising 14_21082261_T_G (marker 1) and 7_140753336_A_T (marker 2), wherein the biomarker composition is the markers shown in Table 24 It may be configured to further include any one or more markers.

In addition, in order to determine the responsiveness to a drug for head and neck cancer, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression, the biomarker composition, which is a detection target, is 14_21082261_T_G (marker 1) and 7_140753336_A_T (marker 2) comprises a diagnostic chip for detecting biomarker composition for determining head and neck cancer drug reactivity, wherein the biomarker composition is any one or more of the markers listed in Table 24 It may be configured to further include.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the lung cancer drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 2_217847583_C_T (Marker 1 ), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4) and 17_81206909_A_C (marker 5) comprising a biomarker composition for determining the reactivity of the lung cancer drug, wherein the biomarker composition , It may be configured to further include any one or more of the markers listed in Table 25.

And the present invention, in order to determine the reactivity to the lung cancer drug, by detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the lung cancer drug, the biomarker The composition includes a method for determining lung cancer drug reactivity using a biomarker composition comprising 2_217847583_C_T (marker 1), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4), and 17_81206909_A_C (marker 5). In this case, the biomarker composition may further include any one or more markers among the markers listed in Table 25.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining reactivity to a lung cancer drug, wherein the biomarker composition is 2_217847583_C_T (Marker 1), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4) and 17_81206909_A_C (marker 5) comprising a diagnostic chip for biomarker composition detection for lung cancer drug reactivity determination At this time, the bio-marker composition may be configured to further include any one or more of the markers listed in Table 25.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to a sarcoma cancer drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 1_26457907_T_G (marker 1), 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4) and 22_18847351_G_C (marker 5) comprises a biomarker composition for the determination of the reactivity of the sarcoma cancer drug, wherein the biomarker The composition may further include any one or more of the markers listed in Table 26.

In addition, the present invention is a method for determining the reactivity to a sarcoma cancer drug by detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression, in order to determine the reactivity to a sarcoma cancer drug. Biomarker composition, 1_26457907_T_G (marker 1), 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4) and 22_18847351_G_C (marker 5) comprising a biomarker composition for determining the reactivity of the sarcoma cancer drug In this case, the biomarker composition may be configured to further include any one or more of the markers listed in Table 26.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing mutations that modulate gene expression, in order to determine responsiveness to a sarcoma cancer drug, wherein the biomarker composition is a detection target, Includes diagnostic chips for detecting biomarker composition for bioreactive drug composition determination including 1_26457907_T_G (marker 1), 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4) and 22_18847351_G_C (marker 5) And, at this time, the biomarker composition, may be configured to further include any one or more of the markers listed in Table 26.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the ABL drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 15_59223315_G_A (Marker 1 ) And 13_30465849_T_C (marker 2) comprises a biomarker composition for determining ABL drug responsiveness, wherein the biomarker composition further comprises any one or more of the markers listed in Table 27. It might be.

And the present invention, in order to determine the reactivity to the ABL drug, in the method of detecting the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the ABL drug, the biomarker The composition includes a method for determining ABL drug reactivity using a biomarker composition comprising 15_59223315_G_A (marker 1) and 13_30465849_T_C (marker 2), wherein the biomarker composition is any of the markers listed in Table 27 It may be configured to further include the above markers.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining reactivity to an ABL drug, wherein the biomarker composition is 15_59223315_G_A (Marker 1) and 13_30465849_T_C (Marker 2) comprises a diagnostic chip for detecting a biomarker composition for determining ABL drug reactivity, wherein the biomarker composition, any one or more of the markers listed in Table 27 It may be configured to further include.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the CHROMATIN drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 2_72891611_A_C (Marker 1 ) And 1_8013331_A_G (marker 2), comprising a biomarker composition for determining CHROMATIN drug reactivity, wherein the biomarker composition is composed of any one or more of the markers listed in Table 28. It might be.

And the present invention, in order to determine the reactivity to the CHROMATIN drug, by detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the CHROMATIN drug, the biomarker The composition comprises 2_72891611_A_C (marker 1) and 1_8013331_A_G (marker 2), wherein the biomarker composition may further include any one or more of the markers listed in Table 28.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a mutation that modulates gene expression, for determining reactivity to a CHROMATIN drug, the biomarker composition being the target of detection is 2_72891611_A_C (Marker 1) and 1_8013331_A_G (marker 2) comprises a diagnostic chip for detecting biomarker compositions for determining CHROMATIN drug reactivity, wherein the biomarker composition is any one or more of the markers listed in Table 28 It may be configured to further include a marker.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the EGFR drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 9_111597344_C_A (Marker 1 ) And 18_47115026_C_T (marker 2) comprises a biomarker composition for determining EGFR drug reactivity, wherein the biomarker composition is composed of any one or more of the markers listed in Table 29 It might be.

And the present invention, in order to determine the reactivity to the EGFR drug, by detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the EGFR drug, the biomarker The composition includes a method for determining EGFR drug reactivity using a biomarker composition comprising 9_111597344_C_A (marker 1) and 18_47115026_C_T (marker 2), wherein the biomarker composition is any one of the markers listed in Table 29 It may be configured to further include the above markers.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining responsiveness to an EGFR drug, wherein the biomarker composition is 9_111597344_C_A (Marker 1) and 18_47115026_C_T (Marker 2) comprises a diagnostic chip for detecting a biomarker composition for EGFR drug reactivity determination, wherein the biomarker composition is any one or more of the markers listed in Table 29 It may be configured to further include a marker.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the ERK_MAPK drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression, the biomarker composition is 5_142319698_T_G (Marker 1 ) And 12_89350540_G_A (marker 1) comprises a biomarker composition for determining ERK_MAPK drug responsiveness, wherein the biomarker composition further comprises any one or more of the markers listed in Table 30. It might be.

And the present invention, in order to determine the reactivity to the ERK_MAPK drug, in the method of detecting the biomarker composition composed of a combination of markers containing mutations that regulate gene expression, to determine the reactivity to the ERK_MAPK drug, the biomarker The composition includes an ERK_MAPK drug reactivity determination method using a biomarker composition comprising 5_142319698_T_G (marker 1) and 12_89350540_G_A (marker 1), wherein the biomarker composition is any one of the markers listed in Table 30 It may be configured to further include the above markers.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining reactivity to ERK_MAPK drugs, wherein the biomarker composition is 5_142319698_T_G (Marker 1) and 12_89350540_G_A (Marker 1) comprises a diagnostic chip for detecting a biomarker composition for determining drug reactivity ERK_MAPK, wherein the biomarker composition is any one or more of the markers listed in Table 30 It may be configured to further include a marker.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the IGFR drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is X_119618658_T_G (Marker 1 ) And 1_16148437_A_C (marker 2) comprises a biomarker composition for determination of IGFR drug reactivity, wherein the biomarker composition is configured to further include any one or more of the markers listed in Table 31 It might be.

And the present invention, in order to determine the reactivity to the IGFR drug, in a method of determining a reactivity to the IGFR drug by detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression, the biomarker The composition includes an IGFR drug reactivity determination method using a biomarker composition comprising X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2), wherein the biomarker composition is any of the markers listed in Table 31 It may be configured to further include the above markers.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression, in order to determine responsiveness to an IGFR drug, wherein the biomarker composition is X_119618658_T_G (Marker 1) and 1_16148437_A_C (Marker 2) comprises a diagnostic chip for detecting biomarker compositions for IGFR drug reactivity determination, wherein the biomarker composition is any one or more of the markers listed in Table 31 It may be configured to further include a marker.

On the other hand, a preferred embodiment of the present invention, in order to determine the reactivity to the MITOSIS drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, the biomarker composition is 1_85581605_TA_T (Marker 1 ) And 6_135201764_A_C (marker 2) comprising a biomarker composition for determination of MITOSIS drug reactivity, wherein the biomarker composition is to be configured by further comprising any one or more of the markers listed in Table 32 It might be.

In addition, the present invention is a method for determining the reactivity to a MITOSIS drug by detecting a biomarker composition composed of a combination of markers containing a mutation that controls gene expression, in order to determine the reactivity to a MITOSIS drug. The composition includes a method for determining the reactivity of MITOSIS drug using a biomarker composition comprising 1_85581605_TA_T (marker 1) and 6_135201764_A_C (marker 2), wherein the biomarker composition is any one of the markers listed in Table 32 It may be configured to further include the above markers.

In addition, the present invention is a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression, in order to determine reactivity to a MITOSIS drug, wherein the biomarker composition is 1_85581605_TA_T (Marker 1) and 6_135201764_A_C (Marker 2) comprises a diagnostic chip for detecting a biomarker composition for determining drug reactivity, and wherein the biomarker composition is any one or more of the markers listed in Table 32 It may be configured to further include a marker.

Hereinafter, referring to the accompanying drawings, a functional haplo typing system and method using cancer drug responsiveness, linked gene expression information, and copy number variation for a virtual clinical trial according to a specific embodiment of the present invention will be described.

Prior to the description, first, the effects, features, and methods of achieving the present invention will be clarified in the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, and only the embodiments allow the disclosure of the present invention to be complete, and common knowledge in the technical field to which the present invention pertains. It is provided to fully inform the holder of the scope of the invention, and the invention is only defined by the scope of the claims.

In the description of the embodiments of the present invention, when it is determined that a detailed description of known functions or configurations may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted, and terms to be described later in the embodiments of the present invention These terms are defined in consideration of the functions of the user, and may vary depending on the user's or operator's intention or customs. Therefore, the definition should be made based on the contents throughout this specification.

1 is an exemplary diagram showing a quantitative trait location (QTL), genetic replication number variation, and RNA expression example for predicting a drug response according to the present invention, and FIG. 2 is a drug reactivity using the genetic biomarker according to the present invention. Figure 3 is an exemplary diagram showing the calculation schema, Figure 3 is an exemplary diagram showing the relationship between the genetic biomarker of breast cancer and drug response according to the present invention, Figure 4 is NGS input and drug response and RNA expression network according to the present invention 5 is an exemplary view showing a correlation between a cell line drug response value (IC50) and a functional hypoflow type according to the present invention, and FIG. 6 is a quantitative trait location (QTL) according to the present invention. An exemplary view showing a drug response correlation, FIG. 7 is an exemplary view showing a variation, RNA expression, gene replication number variation, and a drug response network according to the present invention, and FIG. 8 is a variation and correlation cell line according to the present invention , Cancer, drug reaction, RNA And CNV amplification example, FIG. 9 is an exemplary diagram showing a functional hypoflow type and drug reactivity correlation calculation schema according to the present invention, and FIG. 10 is a functional hypoflow type and drug reactivity network according to the present invention 11 is an exemplary view showing an example of a functional underflow type and gene expression and gene replication modification according to the present invention, and FIG. 12 is an example showing a functional underflow type definition according to the present invention. FIG. 13 is an exemplary view showing an example of FRH method and gene expression and drug reactivity prediction according to the present invention, and FIG. 14 is an example of the FRH according to the present invention, wherein the average IC50 value is 1.0. 15 is an exemplary view showing an example in which the difference in average IC50 value is 1.5 as an example of FRH according to the present invention, and FIG. 16 is a functional underflow type and gene expression according to the present invention. Example showing an example It is an attempt, and FIG. 17 is an exemplary view showing a specific cancer drug pathway-based drug response prediction model generation example according to the present invention, and FIG. 18 is a functional hypoflow type according to the present invention and a drug reactivity relationship R ^ 2 is an exemplary view showing FIG. 19 is an exemplary view showing an embodiment of FRH having a high FRH correlation with Afatinib drug in the example shown in FIG. 18, and FIG. 20 is Afatinib in the example shown in FIG. It is an exemplary view showing an embodiment of a prediction model using FRH having a high correlation with drugs and FRH, and FIG. 21 is an exemplary view showing an embodiment of predicting drug response of blood cancer using FRH according to the present invention, 22 is an exemplary view showing an example of an available system using FRH according to the present invention, and FIG. 23 is an example of a method of manufacturing a cancer and drug companion diagnostic chip using the FRH biomarker according to the present invention Illustrative diagram shown, Figure 24 is the present foot For an illustration for explaining an arrangement of a biomarker expressed by a structure diagram.

The present invention is basically, (A) quantitative RNA location information (QTL) of gene RNA expression information and replication variation information that is difficult to clinically extract from cancer patients, (B) non-clinical cell line DB (GDSC and CCLE) ), Using the common data, such as gene RNA expression information and copy number mutation information and drug-reactivity correlation experiment information, and then integrating the steps (A) and (B) to quantitative quantitative position (QTL) And the cancer drug response correlation is calculated to generate a predictive model.

Then, based on genomic information that can be obtained from cancer patients, the haplotype including functional information is calculated to predict drug response information of cancer patients.

Figure 1 shows an example of quantitative trait location (QTL), genetic replication variability and RNA expression for predicting drug response. That is, in the eQTL experimental example of ①, it is shown that it is regulated by direct (cis) and indirect (trans) methods of mutation and expression, and ② Drug-Gene Expression of ② shows the correlation between drug and RNA expression. And Drug Cell viabillity in ③ shows the relationship between drug concentration and cell activity, and Drug-CNV in ④ shows the correlation between drug concentration and gene copy number variation (CNV). And Expression-CNV in ⑤ shows the correlation between gene expression and copy number variation (CNV).

That is, Figure 1 shows that the concentration of the drug and RNA expression and gene replication variation (CNV) correlate with each other, and in many cases, RNA expression and gene replication variation (CNV) are the cause of it. Shows correlation with single and multiple mutations.

In FIG. 2, in the schema for calculating the drug reactivity using a genetic biomarker, most known active drugs are divided into a drug-sensitive group and a drug-resistant group, wherein the sensitivity and resistance are closely related to the genetic biomarker. Connected.

Here, the genetic biomarker is composed of reproductive and somatic mutations, driver mutations, replication mutations, functional haplotype mutations, epigenetic mutations methylation and gene expression.

And, Figure 3 shows an example of the relationship between the genetic biomarker of breast cancer and drug responsiveness. A) Schematic diagram showing the mechanism of genetic biomarkers, when the Her2 gene is overexpressed, tratuzumab, a drug targeting the cell surface receptor, lapatinib targeting the antagonist in the cytoplasm inside the cell, and two biomarkers PI3CA And PTEN locations. B) The graph shows the calculated results of drug reactivity in the case of tratuzumab and lapatinib in the case where the wild type and PI3CA have mutations and does not function up to PTEN, and the biomarker according to the position of the drug target in the drug pathway mechanism. It is shown that the variation of the drug reactivity for 1 and 2 is different.

Meanwhile, FIG. 4 shows an example of NGS input, drug reaction, and RNA expression network.

The basic structure of NGS input, drug response, and RNA expression network is: A) Predicted amplification / decrease of gene RNA overexpression / low expression and gene copy number variation based on quantitative trait location (QTL) calculated from NGS input data, B) Using non-clinical common drug reactivity data, gene expression data, and correlation information, C) Predict the quantitative trait location (QTL) -based drug response in clinical practice.

The present invention can be described as a process of obtaining A) quantitative trait location (QTL) information, B) gene RNA expression information and drug reactivity test data library (DB), and C) predicting drug reactivity. This is because, in general, it is difficult to obtain the drug response information and gene expression information of step B) in a short time for the patient, or partly impossible.

Accordingly, FIGS. 1 to 4 secure single and multiple mutation information related to quantitative trait location (QTL) information based on genomic information and RNA expression information from a patient, and are non-clinical (in vitro) cell lines that are common drug reactivity information. It is a method of making connection with experimental information and applying it to patients in clinical practice.

5 is an example of the correlation between the cell line drug response value (IC50) and the functional hypoflow type, and FIG. 5 shows an example of finally calculating the correlation between the cell lines and the drug reactivity information and the functional hypoflow type with the Pearson correlation. have. In FIG. 5, 265 drugs are classified into 18 (Dn) drug pathways and applied, and the functional subtype is already based on quantitative trait location (QTL) information in each cell line genome for 12 carcinomas (Cancer N). It shows a schematic diagram of finding the Pearson correlation by replacing the combinations (multivariations) of mutations related to the response with a hash number.

And Figure 6 shows an exemplary diagram of the correlation between the quantitative trait location (QTL) and the drug response. ① is eQTL, ② is cQTL, ③ is dQTL, ④ is the correlation between gene RNA expression and gene replication number variation, ⑤ is the correlation between drug concentration and gene RNA expression, and ⑥ is the correlation between drug concentration and gene replication number variation.

In the present invention, ① eQTL and ② cQTL are used, and ③ to ⑥ show a state as a result or correlation.

FIG. 7 is an exemplary diagram showing a network structure of mutation, RNA expression, gene replication number variation, and drug response, and is a schematic diagram in which networking of the content shown in FIG. 6 is made with respect to each other, and genotype (single mutation), ha It shows the relationship between flow type (combination and multivariate) and conditional expressions of drug reactions.

In the present invention, the functional subflow type collectively refers to both single and multiple variants.

In addition, each variation is collected by determining the correlation between gene RNA expression and gene replication number variation by a method of quantitative trait location (QTL) with a p-value <10 ^ 5 or less.

On the other hand, Figure 8 shows an example of cell line, cancer, drug response, RNA expression and CNV amplification correlated with mutation. At this time, examples of mutually related mutations and cell lines, cancer, drug reactions, RNA expression, and CNV amplification are finally selected quantitative trait location (QTL) -based drug responsiveness-mutation-RNA expression-CNV as one object.

In addition, the variation (genotype) may be linked to the location of the chromosome, the variation type, the amino acid variation, information on whether or not the biomarker is used.

On the other hand, according to the functional hypoflow type and the drug reaction correlation calculation schema shown in FIG. 9, the present invention is largely composed of the first step and the second step.

The first step is a step of generating a location collection of quantitative trait positions (QTLs), and the second step is a step of calculating the correlation between the functional hypoflow type and the drug response.

Specifically, the first step is 1) calculating the expression correlation between mutations (4 million in total) and genes (20,000), and 2) gene expression of drugs (265) and cell line genome (1,000) ( Calculating the correlation of each 20,000), 3) collecting the same gene expression pattern associated with multiple or single mutations in 1) and 2), and 4) haplotype (single and Multivariate) is carried out including the step of extracting with drug reactivity.

And the second step is 5) defining such a Haflow type as a function Haflow type (FRH), which is a function and related Haflow type, and expressing the FRH as a hash number and 6) a hash number. Comprising the step of calculating the drug responsive combination correlation test (Pairwise Pearson Test), these processes are repeated in all cancer species.

In addition, FIG. 10 shows a network of functional haplotypes and drug responsiveness, and shows a system for implementing the functional haplotyping method illustrated in FIG. 9.

That is, the process of extracting the functional subflow type by extracting multiple mutations from the Cell Lines (c1 to cN) integrated DB composed of Genotype and the relationship between single or multiple mutations by QTL method and gene RNA expression and drug response data is shown. have.

In addition, in the functional lower flow type and gene RNA expression and gene replication mutant of FIG. 11, the process of FIG. 9 will be described in detail from a functional point of view.

In other words, A) expresses the relationship between drug reactivity information and gene RNA expression as the final result of multiple facets (loci) and Exp, and the relationship between drug reactivity information and gene replication variable (CNV) is expressed as loci and CNV. Is showing.

And B) is a detailed schema for this, in the case of Ln Ic50 for drugs, '-2' indicates sensitivity, '0' indicates intermediate sensitivity, and '2' indicates drug resistance.

On the other hand, multivariate (loci) is described as a collection of locus selected based on quantitative trait location (QTL), and loci is expressed by various types of loci-1, loci-2, ... loci-N, and each The loci type has a frequency in the whole group.

Then, in each frequency group, ln IC50 values (X, Y, ... Z), which are average drug reactivity information, are calculated.

On the other hand, in the case of gene RNA expression, there are three different expression patterns, which can be expressed in over-expression, normal, and under-exprfession formats, and the loci type and In the same way, frequency can be grouped in each type, and average Ln IC50 values (X ', Y', ... Z ') in each group are calculated.

In the same way, in the case of CNV, which is a replication variable, it is divided into amplification, no change, and deletion, and the ln IC50 value, which is the average drug reactivity information in each frequency group. X ", Y", ... Z ") are calculated.

In addition, all the loci, gene-exp, and gene-CNV values can be expressed on a scale of 0 to 1 in the form of weights.

Therefore, B) can be described as multiplying the weight by loci and Exp, loci and CNV.

FIG. 12 shows a functional haplotype definition, and in the present invention, a relative functional haplotype refers to a functional haplotype (FRH) and a combination of locus giving significance in eQTL (Loci). It refers to the relationship of the associated Haflow type.

Here, the functional subflow type is the genomic assembly version Dec. 2013 (GRCh38 / hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 Based on the reference sequence, individual cell lines and individuals It is defined as a form with different polymorphism information (allele). And FRH (Exp | IC50) represents the absolute difference in sensitivity of the drug response to the gene expression difference (Normal vs. Over or Under), and FRH (Loci | IC50) is a drug corresponding to the functionally related haplotype for cell lines. This is the difference in the absolute sensitivity of the response.

Therefore, the relationship between the drug response value and the gene RNA expression and the gene RNA expression of the same pattern as the specific type of loci can be linked. For example, in FIG. 12, loci-3 and [1] Exp of [2] It shows that it is connected to -over.

That is, loci-3 has a QTL relationship with RNA expression being over, and when RNA expression is over, the drug reactivity value can be predicted to be the same as the loci-3 drug expression value.

In addition, as shown in [3], FRH (Exp | IC50) shows a large value (max) with a difference in absolute drug response compared to the drug reactivity value at no change, and FRH (Loci | IC50). ) Represents the largest value (max) of the difference in absolute drug response compared to the drug response value at no change (normal) in various haplotypes.

On the other hand, in FIG. 13, through the example of predicting the FRH method and gene expression and drug reactivity, the Haflow type defined in FIG. 12 can be described in more detail.

That is, [1] and [2] of FIG. 13 represent the absolute difference in sensitivity (max or over or under) of the drug response to the gene expression difference, respectively, and [3] is a functionally related haplotype for cell lines. Represents the absolute value sensitivity max difference corresponding to the drug response, and [4] indicates that the difference in the drug response to the expression difference is greater than the low expression, s = 1, and vice versa. Therefore, s = 1 means that overexpression is sensitive to drug response, and S = 0 means that low expression is sensitive to drug response.

And [5] indicates that m = 1 if ds ^ over defined in [1] and [2] is greater than ds ^ under, otherwise m = 0, and if m = 1, a specific loci type is overexpressed in the case of a gene , And when m = 0, it means that the low expression of the gene is associated with a specific loci type.

On the other hand, Figure 14 shows an example of the difference in the average IC50 value '1.0' as an example of the FRH in a table. Here, when the average drug reactivity (LN IC50) is 1, it shows a high positive correlation (pval <2.812 * 10 ^ -7).

In addition, FIG. 15 shows an example data in which the difference of the average IC50 value is '1.5' as an example of FRH in a table. Here, when the average drug reactivity (LN IC50) is 1.5, it shows a much higher negative correlation (pval <7.191 * 10 ^ -7).

In addition, FIG. 16 shows an example of functionally related haplotype and gene expression.

In the case of this example, in the case of blood cancer, it is shown that FRH includes four types. At this time, the variation (locus position) is explained by three different genotypes: 1: Ref Homo, 2: Hetero, and 3: Alt Homo.

And when expressed as a combination of two locus in the blood of the first column, the frequency of each type is the second column, one in '12', one in '21', and one in '11'. 2 and '22' show a majority with 153.

In addition, in the case of '11' for Afatinib drugs, gene expression is overexpression (2.404), and drug reactivity (LN IC50) is -1.21, that is, it is sensitive to Afatinib drugs. To summarize the contents of this example, FRH with two locus combinations overexpresses the EGFR gene in the '11' type, which is responsible for the drug reactivity. Therefore, it can be predicted that FRH is a cell line with '11' type and patients are sensitive to Afatinib drug.

And FIG. 17 illustrates a method for generating a drug response prediction model based on a specific cancer drug pathway. As shown in the figure, a model for predicting a drug response based on a specific cancer drug pathway is 1) a correlation between a function-related haplotype (FRH) and each drug related to a specific drug drug pathway of a specific cancer. Calculates, 2) clusters the correlation information of the metric X-axis and Y-axis consisting of the FRH and drug-reactivity correlations, and 3) collects those with high p-value in the predictive model, and interacts with them. The function is applied to the model, and 4) the drug reactivity is predicted by calculating the FRH related to the drug reactivity with NGS data as input.

On the other hand, the functional flow type shown in FIG. 18 and the drug reactivity relationship R ^ 2 describe an example of the clustering process of 2) correlation information of the method for generating the predictive model of FIG. 17. Here, the cancer type is blood cancer, Y: EGFR pathway 9 drugs, X: FRH haplotype, and each pixel represents the Pearson correlation between the drug response value and FRH, where * indicates significance (pval <0.05), ** indicates significance (pval <0.01).

In addition, blue color shows a positive correlation, and orange color shows a negative correlation.

And FIG. 19 shows an example of FRH having high FRH correlation with Afatinib drug in the example of FIG. 18. In particular, the results show the correlation between the four FRHs (LAMC2_2, JPH1_2, PRKCB_3, CML_1) and drug response.

Meanwhile, FIG. 20 is an example of a prediction model using FRH having a high FRH correlation with Afatinib drug in the example of FIG. 18, and an example of applying 3) interaction function of the prediction model generation method of FIG. 17 to a model will be described. . In particular, 21 FRHs with p-val <0.01 or less are put into an interaction term and an example of applying a linear regression model. In this case, the Pearson correlation is 0.89.

In addition, FIG. 21 shows predicted IC50 (real) values for various drugs (AP-24534, PAC-1, Obatoclax Mesylate, Bleomycin, etc.) with the functional subtype of the genome of one patient with blood cancer. As a result, some drugs were predicted to be highly sensitive, while others were predicted to be highly resistant. And there is a correspondence between the sensitivity of the actual value (IC50 (real)) and the average IC50 (ave) value of the functional Haflow type group.

On the other hand, as shown in Figure 22, the next-generation sequencing data based on the functional haplotypes according to the present invention can be utilized in various areas. That is, it can be used in virtual clinical trials and actual clinical trials, discovery of new drug targets, diagnosis of disease drug susceptibility, and discovery of biomarkers for companion diagnostics.

In the present invention, significant biomarkers were found in diagnosing drug responsiveness through the functional hypoflow type as described above.

The excavated biomarkers are DNA bases containing mutations, which are largely classified according to the type of cancer (CancerClass) and the biomarkers that affect the drug's reactivity to the cancer and the drug's pathway and expression target. It is divided into biomarkers that affect drug reactivity by drug class (DrugClass).

Hereinafter, such biomarkers will be classified and sorted.

First, the classification types for the cancer type (CancerClass) are summarized in [Table 1].

Definition of the cancer genome atlas (TCGA) belonging to CancerClass

division	CancerClass	TCGA	CANCER_NAME
One	Blood cancer	ALLLAMLLCML	Acute lymphoblastic leukemia, Acute Myeloid Leukemia, Chronic Myelogenous Leukemia
2	Female cancer (breast, ovary)	BRCABLCAUCECOVCESC	Bladder Urothelial Carcinoma, Breast invasive carcinoma, Ovarian serous cystadenocarcinoma, Cevical squamous cell carcinoma and endocervical adenocarcinoma, Uterine Corpus Endometrial Carcinoma
3	Brain tumor	LGGNBGBM	Glioblastoma multiforme, Brain Lower Grade Glioma, Neuroblastoma (nb)
4	Head and neck cancer	HNSCTHCA	Head and Neck squamous cell carcinoma, Thyroid carcinoma
5	Lung cancer	LUADLUSCNSCLC	Lung adenocarcinoma, Lung squamous cell carcinoma
6	Sarcoma cancer	SARC	Sarcoma

The cancer classes listed in [Table 1] above are classified by cancer occurrence sites and causes, including blood cancer, female cancer, brain tumor, brain and head and neck, lung cancer, and sarcoma. It is divided into bones.

And TCGA indicates the detailed cancer types classified in 'The cancer genome atlas', and information on each item is listed in [Table 1].

As described above, in the present invention, the biomarkers that affect the reactivity to drugs for each cancer type were calculated through GBLscan using the functional Haflow type.

Specifically, 225 biomarkers of blood cancer (see Table 2), 50 biomarkers of breast and ovary (see Table 4), brain tumors, by type of cancer class 894 biomarkers (see Table 6), 32 head and neck biomarkers (see Table 8), 277 lung lung biomarkers (see Table 10), biomarkers of sarcoma cancer (bone) 331 (see Table 12).

[Table 2] to [Table 12] below show biomarkers discovered by the present invention for each cancer type. Here, the biomarker may be a combination of a single mutation and a multiple mutation, and the forms of the mutations may also be of various forms such as a single nucleotide polymorphism (SNV), an indel, gene copy number variation (CNV), and a chromosomal rearrangement. It can be a mutation.

On the other hand, Gene_EXP displayed in the present invention, as shown in Figure 24, indicates the name of the mRNA expression gene of the biomarker. In addition, the biomarker is expressed in the form of "Marker 1_Marker 2_Marker3_Marker4", and Marker1 indicates a chromosome number containing a mutation and has a value of 1 to 22 or X, Y. . In addition, the marker 2 indicates the starting position of the nucleotide sequence in which the mutation occurred on the chromosome, and the marker 3 indicates the normal base before the mutation and refers to the base of the corresponding position on the reference genome (based on GRCh / hg38). On the other hand, Table 4 shows the mutated base.

That is, the variations expressed in the form of "Mark 1_Mark 2_Mark 3_Mark 4" shown in [Table 2] to [Table 12] and [Table 15] to [Table 27] are in the marker 1 chromosome, Refers to the base sequence in which Mark 3 base from Mark 2 is changed to Mark 4.

Thus, at this time, the biomarker specifically refers to a base sequence consisting of the base of the marker 4, the position from the second position of the marker to the base length of the marker 3 in the marker 1 chromosome.

For example, the biomarker of SEQ ID NO: 1 in [Table 2] was expressed as “14_30910985_T_G”, which means that the base sequence of the 30910985 th base of chromosome 14 is the biomarker, and the sequence of SEQ ID NO: 5 of [Table 2] The biomarker was expressed as `` 13_113524119_TGTCA_T, 13_113510211_T_C, 13_113495576_T_C, 13_113503637_G_T, 13_113539563_C_T '', which means that the bases from the 113524119 bases of chromosome 13 to 113524123 are T (the base of 4 digits is 'deleted', 13 bases) This means that the nucleotide sequence of chromosome 113510211 is C, the 113495576 base of chromosome 13 is C, the 113503637 base of chromosome 13 is T, and the chromosome 113539563 of chromosome 13 is a biomarker.

Looking at the example shown in FIG. 24, in the biomarker described in SEQ ID NO: 29 of [Table 23], in the 'SLC6A12' chromosome, the 190673067th base of chromosome 2 is GT, and the 114323991th base of ninth chromosome is G. it means. At this time, the 190673067th base of chromosome 2 refers to G being substituted with GT.

Meanwhile, as described above, the entire nucleotide sequence of chromosomes 1 to 22 is a genomic assembly version of Dec. 2013 (GRCh38 / hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https: //www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 being based on the reference (reference) sequence.

Table 2 lists the FRHs associated with blood cancer drugs, and markers defining the blood cancer drugs and FRHs associated with them.

In addition, [Table 3] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 2].

In these tables, FRH was expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (P-vlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 2], the reactivity correlation value for each drug is divided into the classification factor 『/』 『Exp_Drug (pval)』, the correlation value (Pvlaue) of the gene reactivity with the corresponding gene expression is arranged according to the order of drugs listed in [Table 2], and 『Ave_VarDrug (pval)』 is 『 Var_Drug (pval) ”means the average value of the calculated values, and“ Rank ”means the number of blood cancer drugs that the corresponding FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

Meanwhile, in FIG. 25, correlation values (P-vlaue) values of major biomarkers among blood biomarkers among the biomarkers listed in Table 2 are displayed in a graph, and FIG. 26 shows genes expressed by the major biomarkers. The correlation values (P-vlaue) values for the fields and blood cancer drugs are plotted.

Reactive biomarkers for blood cancer drugs

No.	FRH	Drug	DrugType	Var (marker)
One	MYB_5	1017_Olaparib / 1054_PD-0332991 / 1175_AG-014699 / 1006_Cytarabine / 1013_Nilotinib / 1495_Olaparib / 1010_Gefitinib / 1050_ZM-447439 / 1019_Bosutinib / 1011_ABT-263 / 1021_Axitinib / 1018_Brazil / 1018_62 2206 / 1032_Afatinib / 1015_CI-1040 / 1020_Lenalidomide / 1066_AZD6482 / 308_XL-880 / 1033_Vismodegib / 1014_RDEA119 / 1049_PD-173074 / 1038_NU-7441	g_integrity / cell_cyc / g_integrity / DNArep / abl / g_integrity / egfr / mitosis / abl / apop / rtk / g_integrity / other / cell_cyc / erk_mapk / rtk / pi3k / egfr / erk_mapk / other / pi3k / rtk / other / erk_mapk / rtk g_integrity	13_37746458_AA_A / 16_46710765_T_A / 11_63382198_CA_C / 14_68477626_CT_C / 7_151221500_CT_C
2	CCND3_2	1006_Cytarabine_1 / 226_GSK1070916_2 / 32_Tozasertib_2 / 1054_Palbociclib_2 / 231_FMK_3 / 1050_ZM447439_3 / 167_OSU-03012_3 / 59_WZ-1-84_3 / 197_Bryostatin_1_2 / 1495_Olaparib_1 / 395	DNArep / mitosis / mitosis / cell_cyc / erk_mapk / mitosis / pi3k / other / other / g_integrity / other / egfr / other	14_68477626_CT_C / 7_151221500_CT_C
3	CLEC11A_2	1014_Refametinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 263_FR-180204_3 / 1242_ (5Z) -7-Oxozeaenol_3 / 1015_CI-1040_2 / 224_AS605240_3 / 1498_Selumetinib_2 / 254_Quizartinib_2 / 29AZ	erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / pi3k / erk_mapk / rtk / erk_mapk	16_46710765_T_A / 5_179863845_T_G
4	SLFN11_1	1494_SN-38_3 / 1259_Talazoparib_3 / 136_Mitomycin-C_1 / 1003_Camptothecin_1 / 1006_Cytarabine_1 / 226_GSK1070916_2 / 134_Etoposide_1 / 1005_Cisplatin_1 / 135_Gemcitabine_1	DNArep / g_integrity / DNArep / DNArep / DNArep / mitosis / DNArep / DNArep / DNArep	1_215675245_T_C
5	GLUL_1	1013_Nilotinib_1 / 1021_Axitinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 34_Imatinib_1 / 52_GNF-2_3 / 1050_ZM447439_3	abl / rtk / erk_mapk / erk_mapk / abl / abl / mitosis	16_46710765_T_A
6	ARRB1_1	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 29_AZ628_3 / 263_FR-180204_3 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other	16_46710765_T_A
7	UBASH3B_1	1006_Cytarabine_1 / 226_GSK1070916_2 / 1050_ZM447439_3 / 211_TL-2-105_3 / 1054_Palbociclib_2 / 279_BIX02189_3 / 282_Pelitinib_2	DNArep / mitosis / mitosis / erk_mapk / cell_cyc / other / egfr	14_68477626_CT_C
8	TNFRSF1A_2	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 29_AZ628_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	16_46710765_T_A / 6_71969190_A_G
9	FLT3_1	277_Linifanib_2 / 249_Cabozantinib_1 / 254_Quizartinib_2 / 308_WIKI4_2 / 226_GSK1070916_2 / 222_BX-912_3 / 153_Midostaurin_2	rtk / rtk / rtk / rtk / mitosis / pi3k / rtk	2_110841381_C_T
10	TAF3_1	1060_PD0325901_2 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	1_75148689_A_T
11	RNF169_1	1013_Nilotinib_1 / 1021_Axitinib_2 / 261_TL-1-85_3 / 260_NG-25_3 / 211_TL-2-105_3 / 295_NVP-BHG712_3	abl / rtk / other / other / erk_mapk / rtk	6_119180436_T_TAA
12	AGTRAP_1	1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1015_CI-1040_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	2_178769706_G_T
13	DDX60L_1	1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 224_AS605240_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / pi3k	6_143772215_C_T
14	MARCH9_1	1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	14_30910985_T_G
15	OSBPL5_1	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1242_ (5Z) -7-Oxozeaenol_3 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk	2_232380431_T_C
16	ZNF22_1	300_CX-5461_3 / 272_AR-42_2 / 226_GSK1070916_2 / 274_Belinostat_1 / 257_NPK76-II-72-1_3 / 276_CAY10603_3	other / chromatin / mitosis / chromatin / mitosis / chromatin	2_97507111_G_A
17	DGAT1_3	1014_Refametinib_2 / 1526_Refametinib_3 / 1021_Axitinib_2 / 1013_Nilotinib_1 / 1060_PD0325901_2 / 1011_Navitoclax_2	erk_mapk / erk_mapk / rtk / abl / erk_mapk / apop	3_38910262_T_C / 11_18484005_G_A / 3_38905381_A_T
18	ORMDL3_2	1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	19_49044101_A_G / 2_178769706_G_T
19	ROPN1L_2	1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	16_33978977_C_T / 2_200876848_T_C
20	MSI2_1	1498_Selumetinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	22_43972861_C_T
21	PSTPIP2_2	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	6_143772215_C_T / 6_143760631_C_A
22	MYL6B_1	1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	11_284257_G_A
23	LPAR6_2	1011_Navitoclax_2 / 1054_Palbociclib_2 / 1021_Axitinib_2 / 1050_ZM447439_3 / 226_GSK1070916_2	apop / cell_cyc / rtk / mitosis / mitosis	X_136033510_GA_G / 12_131908770_A_C
24	RIPK2_5	231_FMK_3 / 226_GSK1070916_2 / 225_Genentech Cpd 10_3 / 203_BMS-345541_3 / 205_Avagacestat_2	erk_mapk / mitosis / mitosis / other / other	6_152444591_GA_G / 19_13993876_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 10_67956845_TA_T
25	KIF15_1	1006_Cytarabine_1 / 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2	DNArep / cell_cyc / mitosis / mitosis	15_100152748_G_A
26	ATP11A_2	1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	2_85880864_T_C / 3_132388903_G_A
27	ZYX_1_9	1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk	11_129905704_C_T
28	SNRPG_5_5	1498_Selumetinib_2 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk / erk_mapk	7_12369637_C_A / 7_12369701_C_T / 7_12369909_A_G / 7_12361157_C_T / 7_12361395_C_T
29	RABGAP1_4_4	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1015_CI-1040_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	3_10260372_A_G / 17_20204460_T_C / 17_20357788_A_G / 17_20205876_C_T
30	AEBP1_5_4	1006_Cytarabine_1 / 167_OSU-03012_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2	DNArep / pi3k / apop / mitosis	16_13922252_CT_C / 13_37746457_TAA_TA / 1_108982799_TA_T / 6_152444591_GA_G / 17_64858885_TA_T
31	HNRNPA0_5_7	226_GSK1070916_2 / 300_CX-5461_3 / 134_Etoposide_1 / 225_Genentech Cpd 10_3	mitosis / other / DNArep / mitosis	11_63382198_CA_C / 15_42211755_GA_G / 15_55680462_CT_C / 20_34750522_TA_T / 11_33353067_AT_A
32	PVRL2_1_15	1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 34_Imatinib_1	erk_mapk / erk_mapk / erk_mapk / abl	17_999610_T_C
33	KIAA1377_1_4	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	19_2896950_T_C
34	THEM4_5_4	226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 300_CX-5461_3 / 175_PAC-1_2	mitosis / pi3k / other / apop	13_37746457_TAA_TA / 7_151221500_CT_C / 1_108982799_TA_T / 2_53919250_GA_G / 15_42211755_GA_G
35	RBM15B_4_4	1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 / 1006_Cytarabine_1	cell_cyc / mitosis / mitosis / DNArep	11_63382198_CA_C / 5_75576972_GA_G / 8_73582883_GA_G / 10_67956845_TA_T
36	C10orf11_1_7	1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	1_13344015_T_C
37	NSMAF_1_7	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 29_AZ628_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk	1_117088769_T_C
38	FRAT2_2_9	1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	1_215813880_T_C / 1_215838019_T_C
39	LRPAP1_2_3	1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk	7_36335190_G_A / 22_39052745_T_C
40	PRAM1_3_3	1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	7_128805316_G_A / 2_178769706_G_T / 2_232380380_A_G
41	RAG1_2_3	182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 1006_Cytarabine_1	apop / apop / DNArep	19_11301321_TA_T / 4_105719027_C_A
42	CARHSP1_2_3	1006_Cytarabine_1 / 226_GSK1070916_2 / 1054_Palbociclib_2	DNArep / mitosis / cell_cyc	14_68477626_CT_C / 13_24781827_GTT_GT
43	MBLAC1_1_3	1498_Selumetinib_2 / 1014_Refametinib_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk	3_179365291_C_T
44	RAG2_3_4	1006_Cytarabine_1 / 175_PAC-1_2 / 300_CX-5461_3	DNArep / apop / other	3_112112876_TA_T / 12_21806064_CA_C / 19_11301321_TA_T
45	HNMT_1_4	1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk	1_1756186_T_C
46	KCTD7_2_5	1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk	11_63719914_T_C / 11_63646490_AAAAT_A
47	GSN_1_6	1498_Selumetinib_2 / 1372_Trametinib_1 / 1060_PD0325901_2	erk_mapk / erk_mapk / erk_mapk	11_129905704_C_T
48	CBFB_2_5	1006_Cytarabine_1 / 182_Obatoclax Mesylate_2 / 1004_Vinblastine_1	DNArep / apop / cytoskeleton	15_74183919_A_G / 3_112112876_TA_T
49	FBXO33_1_4	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk	8_143538013_T_C
50	ZBED4_2_4	1054_Palbociclib_2 / 257_NPK76-II-72-1_3 / 1011_Navitoclax_2	cell_cyc / mitosis / apop	7_100590017_T_G / 22_23698377_AT_A
51	COPS8_5_6	1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk	11_69072603_C_T / 11_124023539_A_G / 16_57082546_T_C / 6_31878964_C_A / 7_100220478_G_A
52	ISG20_1_12	1014_Refametinib_2 / 1060_PD0325901_2 / 263_FR-180204_3	erk_mapk / erk_mapk / erk_mapk	5_179863845_T_G
53	LGALS12_3_4	1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk	14_63384641_T_C / 7_128804766_A_G / 7_128805316_G_A
54	SNRNP48_5_3	1006_Cytarabine_1 / 1050_ZM447439_3 / 1054_Palbociclib_2	DNArep / mitosis / cell_cyc	16_57460490_GA_G / 16_30280420_GA_G / 8_108228149_GA_G / 1_179120104_GA_G / 9_67192757_GA_G
55	VPS37C_3_4	182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 205_Avagacestat_2	apop / apop / other	5_146267624_CT_C / 3_160416453_CT_C / 12_15623289_TA_T
56	ATP6V0A1_1_3	1494_SN-38_3 / 226_GSK1070916_2 / 1006_Cytarabine_1	DNArep / mitosis / DNArep	11_63382198_CA_C
57	HEATR5A_5_6	205_Avagacestat_2 / 226_GSK1070916_2 / 192_LFM-A13_3	other / mitosis / other	7_151221500_CT_C / 9_120989554_CT_C / 4_106236542_TA_T / 7_77937691_AT_A / 15_42211755_GA_G
58	ENG_2_8	249_Cabozantinib_1 / 308_WIKI4_2 / 263_FR-180204_3	rtk / rtk / erk_mapk	3_186558604_C_T / 22_29806785_G_C
59	USF1_5_7	228_AKT_inhibitor_VIII_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2	pi3k / apop / mitosis	6_163478762_CT_C / 17_46332538_GT_G / 7_74758055_CT_C / 9_100450496_GT_G / 1_176043330_GA_G
60	GRB10_2_11	1014_Refametinib_2 / 1060_PD0325901_2 / 1013_Nilotinib_1	erk_mapk / erk_mapk / abl	12_56425138_C_T / 7_51028450_A_G
61	ZNF415_2_4	286_KIN001-236_3 / 205_Avagacestat_2 / 167_OSU-03012_3	other / other / pi3k	1_225147359_GT_G / 19_1057777_GA_G
62	DMTF1_1_4	1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk	1_16758972_T_G
63	MSL2_4_5	226_GSK1070916_2 / 205_Avagacestat_2 / 1050_ZM447439_3	mitosis / other / mitosis	13_37746457_TAA_TA / 8_73582883_GA_G / 5_64507681_TA_T / 7_73465568_GA_G
64	ATP7B_2_6	1013_Nilotinib_1 / 261_TL-1-85_3 / 260_NG-25_3	abl / other / other	5_176347862_G_T / 5_176336593_G_A
65	MANBAL_1_5	305_TPCA-1_3 / 1013_Nilotinib_1 / 155_Ponatinib_2	other / abl / abl	1_24074187_A_G
66	STOX1_1_3	182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 226_GSK1070916_2	apop / apop / mitosis	9_67192757_GA_G
67	PRKCB_2_4	261_TL-1-85_3 / 295_NVP-BHG712_3 / 260_NG-25_3	other / rtk / other	2_68818005_T_G / 1_24074187_A_G
68	PNPLA8_3_5	224_AS605240_3 / 1014_Refametinib_2 / 1526_Refametinib_3	pi3k / erk_mapk / erk_mapk	17_21300996_G_T / 17_21301003_T_C / 17_21301006_A_G
69	ACCS_3_2	1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk	11_44107740_C_A / 9_61066407_C_T / 7_135196179_C_T
70	BANP_1_2	1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk	9_33270750_G_T
71	ARID1A_2_3	1054_Palbociclib_2 / 1050_ZM447439_3	cell_cyc / mitosis	7_21862122_CT_C / 11_63382198_CA_C
72	ELOVL5_1_4	1013_Nilotinib_1 / 1054_Palbociclib_2	abl / cell_cyc	13_37746457_TAA_TA
73	N4BP2_5_2	175_PAC-1_2 / 257_NPK76-II-72-1_3	apop / mitosis	19_11301321_TA_T / 5_146267624_CT_C / 9_120989554_CT_C / 13_37746457_TAA_TA / 16_84087473_CAA_C
74	LIMS2_5_3	205_Avagacestat_2 / 226_GSK1070916_2	other / mitosis	3_196805277_CT_C / 11_63382198_CA_C / 15_41478441_CT_C / 6_166418092_GA_G / 14_54478163_TA_T
75	DPCD_1_2	226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3	mitosis / pi3k	15_42211755_GA_G
76	KATNB1_5_2	1006_Cytarabine_1 / 1054_Palbociclib_2	DNArep / cell_cyc	4_183646278_TA_T / 20_38562748_GT_G / 1_84490478_CT_C / 2_200412288_CT_C / X_19006308_TA_T
77	RBM18_1_3	1011_Navitoclax_2 / 1014_Refametinib_2	apop / erk_mapk	10_131944182_G_C
78	EWSR1_1_2	1054_Palbociclib_2 / 226_GSK1070916_2	cell_cyc / mitosis	14_68477626_CT_C
79	SDC4_1_5	245_UNC0638_3 / 196_Phenformin_3	chromatin / metabol	1_24074187_A_G
80	LCK_5_3	182_Obatoclax Mesylate_2 / 175_PAC-1_2	apop / apop	6_163478762_CT_C / 10_70860377_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 5_146267624_CT_C
81	GNA15_1_9	1011_Navitoclax_2 / 226_GSK1070916_2	apop / mitosis	9_33798019_A_G
82	S1PR2_2_8	1014_Refametinib_2 / 224_AS605240_3	erk_mapk / pi3k	1_204261453_G_A / 3_54386725_A_G
83	SOX4_2_2	226_GSK1070916_2 / 1006_Cytarabine_1	mitosis / DNArep	13_37746457_TAA_TA / 6_152444591_GA_G
84	MPP1_1_19	1013_Nilotinib_1 / 263_FR-180204_3	abl / erk_mapk	9_33798019_A_G
85	TRIM26_1_5	277_Linifanib_2 / 1526_Refametinib_3	rtk / erk_mapk	11_129905704_C_T
86	NRN1_2_2	1006_Cytarabine_1 / 175_PAC-1_2	DNArep / apop	20_24959128_C_T / 6_136108863_GA_G
87	PHACTR2_1_4	1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk	5_146013801_C_T
88	TRAF3IP2_2_2	1175_Rucaparib_3 / 1017_Olaparib_2	g_integrity / g_integrity	1_149929093_CA_C / 12_27688992_CT_C
89	MLF1IP_1_2	1054_Palbociclib_2 / 1006_Cytarabine_1	cell_cyc / DNArep	10_69097096_G_A
90	PELI2_5_7	226_GSK1070916_2 / 257_NPK76-II-72-1_3	mitosis / mitosis	3_129433338_GT_G / 19_11301321_TA_T / 6_152444591_GA_G / 5_60605865_GA_G / 11_63382198_CA_C
91	HNRNPA1L2_1_2	1054_Palbociclib_2 / 1006_Cytarabine_1	cell_cyc / DNArep	11_33353067_AT_A
92	BCL11B_5_3	205_Avagacestat_2 / 231_FMK_3	other / erk_mapk	13_24781827_GTT_GT / 10_67956845_TA_T / 3_196805277_CT_C / 11_63382198_CA_C / 19_13993876_CT_C
93	TTF1_5_6	226_GSK1070916_2 / 1006_Cytarabine_1	mitosis / DNArep	8_28850105_GA_G / 6_163478762_CT_C / 13_37746457_TAA_TA / 11_63382198_CA_C / 5_146267624_CT_C
94	SKA3_1_2	1054_Palbociclib_2 / 1006_Cytarabine_1	cell_cyc / DNArep	6_163478762_CT_C
95	ECI1_1_2	205_Avagacestat_2 / 1072_Avagacestat_2	other / other	1_247588429_C_G
96	LAPTM4B_1_8	1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk	20_56366031_C_T
97	C11orf74_4_5	1014_Refametinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk	2_237751320_TAA_T / 16_21533198_T_C / 2_216109160_C_A / 16_21520152_G_A
98	RNF24_1_12	1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk	5_179863845_T_G
99	CRB3_1_4	1021_Axitinib_2 / 277_Linifanib_2	rtk / rtk	15_98922244_C_T
100	CNTROB_5_3	226_GSK1070916_2 / 1050_ZM447439_3	mitosis / mitosis	16_15068286_TA_T / 5_64507681_TA_T / 8_42906145_TC_T / 3_129433338_GT_G / 1_179120104_GA_G
101	KIAA1967_5_2	211_TL-2-105_3 / 257_NPK76-II-72-1_3	erk_mapk / mitosis	11_107336715_TA_T / 1_22491646_AT_A / 22_23698377_AT_A / 13_37746457_TAA_TA / 3_196805277_CT_C
102	KRT10_1_3	1014_Refametinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk	7_92671549_C_T
103	VIT_1_2	1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk	1_176944072_A_T
104	TMEM173_2_7	1526_Refametinib_3 / 1014_Refametinib_2	erk_mapk / erk_mapk	1_201199371_G_A / 1_201200426_T_G
105	SGCB_1_3	1014_Refametinib_2 / 1015_CI-1040_2	erk_mapk / erk_mapk	17_40035671_A_G
106	DTD1_3_4	226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3	mitosis / pi3k	5_77411610_TA_T / 2_15396385_GA_G / 11_63382198_CA_C
107	DYSF_1_3	1014_Refametinib_2 / 1015_CI-1040_2	erk_mapk / erk_mapk	1_25390874_C_G
108	AP2S1_1_3	1060_PD0325901_2 / 1372_Trametinib_1	erk_mapk / erk_mapk	10_68572309_C_T
109	EMILIN2_1_11	1526_Refametinib_3 / 1014_Refametinib_2	erk_mapk / erk_mapk	5_179863845_T_G
110	SLC38A1_1_6	1014_Refametinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk	7_114653804_G_T
111	SGSM2_4_1	226_GSK1070916_2	mitosis	13_97982483_AT_A / 2_63842143_GA_G / 7_77256452_A_G / 4_84631729_G_T
112	ADAM15_1_1	1026_Tanespimycin_2	other	1_75148689_A_T
113	JPH1_2_1	211_TL-2-105_3	erk_mapk	16_81858185_C_G / 5_128345465_A_C
114	S100A8_1_3	1498_Selumetinib_2	erk_mapk	12_11091570_G_A
115	SQSTM1_2_1	182_Obatoclax Mesylate_2	apop	13_24781827_GTT_GT / 19_11301321_TA_T
116	ANXA2_1_1	1026_Tanespimycin_2	other	4_36214492_A_T
117	CMBL_1_2	1013_Nilotinib_1	abl	11_117203393_G_A
118	CABLES2_1_1	1053_MK-2206_2	pi3k	17_74794950_A_G
119	NDST3_2_1	205_Avagacestat_2	other	13_24781827_GTT_GT / 11_90163472_A_C
120	LMNA_1_1	1026_Tanespimycin_2	other	12_120579461_C_T
121	SP1_5_1	333_T0901317_3	other	14_35627049_G_GA / 7_23187041_C_T / 2_61835958_TA_T / X_52753184_G_T / 2_119608507_T_G
122	CDCA7_1_2	1054_Palbociclib_2	cell_cyc	20_46358679_C_G
123	NFYB_1_1	1006_Cytarabine_1	DNArep	20_46358679_C_G
124	SLFN5_2_1	1378_Bleomycin (50uM) _1	DNArep	4_186199057_C_A / 6_116125413_A_G
125	CREG1_3_1	1378_Bleomycin (50uM) _1	DNArep	9_12704725_C_T / 17_47820165_C_A / 17_47819112_T_C
126	DAD1_1_1	1006_Cytarabine_1	DNArep	12_54182016_C_A
127	SURF4_1_4	35_NVP-TAE684_3	rtk	14_101856659_C_G
128	CDK6_1_1	1011_Navitoclax_2	apop	9_33798019_A_G
129	TBCD_5_1	1054_Palbociclib_2	cell_cyc	11_63382198_CA_C / 10_67956845_TA_T / 14_68477626_CT_C / 13_37746457_TAA_TA / 8_73582883_GA_G
130	FLRT3_1_1	1378_Bleomycin (50uM) _1	DNArep	17_8012602_G_A
131	FUCA2_2_1	1526_Refametinib_3	erk_mapk	12_10418492_T_G / 1_3385157_C_T
132	MAPK7_1_1	1054_Palbociclib_2	cell_cyc	7_73465568_GA_G
133	IER3_1_1	1378_Bleomycin (50uM) _1	DNArep	20_62310091_T_G
134	U2AF1_1_1	167_OSU-03012_3	pi3k	9_76023648_GA_G
135	PLA2G12A_1_3	224_AS605240_3	pi3k	1_70189288_A_C
136	CBX2_2_1	1006_Cytarabine_1	DNArep	2_161993434_TA_T / 12_109568919_GT_G
137	MGAT4A_5_1	175_PAC-1_2	apop	13_37746457_TAA_TA / 20_2493490_GA_G / 6_41090123_AT_A / 2_53919250_GA_G / 16_30280420_GA_G
138	STARD10_1_1	1026_Tanespimycin_2	other	20_62327488_A_C
139	CSRNP2_1_1	205_Avagacestat_2	other	22_29978883_CT_C
140	DOK2_2_1	1526_Refametinib_3	erk_mapk	2_23637298_G_A / 2_23642306_G_A
141	VOPP1_1_1	308_WIKI4_2	rtk	22_38427824_A_C
142	PLOD1_1_1	175_PAC-1_2	apop	10_99880039_G_A
143	C3AR1_1_1	1014_Refametinib_2	erk_mapk	7_147977856_A_T
144	CYSLTR1_1_1	1526_Refametinib_3	erk_mapk	11_129905704_C_T
145	S100A6_1_1	1026_Tanespimycin_2	other	12_125519394_A_T
146	ZADH2_1_1	1011_Navitoclax_2	apop	4_86769845_A_G
147	EXOSC9_5_2	167_OSU-03012_3	pi3k	8_108228149_GA_G / 16_57460490_GA_G / 6_31657145_CA_C / 15_50725184_GT_G / 20_33367013_TA_T
148	ZC3H4_2_1	1054_Palbociclib_2	cell_cyc	1_247256362_C_T / 1_247256207_T_C
149	BARD1_1_2	175_PAC-1_2	apop	9_133405414_T_G
150	MCL1_1_1	1011_Navitoclax_2	apop	14_60466034_G_A
151	NINL_3_4	203_BMS-345541_3	other	13_24781827_GTT_GT / 13_37746457_TAA_TA / 11_33353067_AT_A
152	HYI_5_1	226_GSK1070916_2	mitosis	7_151221500_CT_C / 19_1057777_GA_G / 15_42211755_GA_G / 15_34915209_AT_A / 6_30329241_CA_C
153	USP49_1_1	1006_Cytarabine_1	DNArep	7_147638841_CT_C
154	EPB41_1_3	1378_Bleomycin (50uM) _1	DNArep	11_1758992_A_C
155	NFAM1_1_1	1526_Refametinib_3	erk_mapk	9_15848985_C_T
156	SIVA1_5_1	175_PAC-1_2	apop	6_163478762_CT_C / 13_37746457_TAA_TA / 2_161993434_TA_T / 9_120989554_CT_C / 13_39034198_TA_T
157	LRG1_1_2	1026_Tanespimycin_2	other	13_28073352_GA_G
158	TMPRSS15_1	1377_Afatinib_1	egfr	21_39898596_C_A
159	G0S2_1	281_Alectinib_2	rtk	5_35904512_G_T
160	PPIP5K2_2	261_TL-1-85_3	other	2_178769706_G_T / 11_129905704_C_T
161	AGPAT3_4	182_Obatoclax Mesylate_2	apop	17_76289951_CA_C / 2_63842143_GA_G / 13_97982483_AT_A / 12_48679260_CA_C
162	AS3MT_5	226_GSK1070916_2	mitosis	7_20786651_GA_G / 13_24781827_GTT_GT / 7_77937691_AT_A / 3_160416453_CT_C / 5_95507014_TA_T
163	PIK3R3_1	228_AKT_inhibitor_VIII_3	pi3k	2_53919250_GA_G
164	CRY1_2	226_GSK1070916_2	mitosis	19_1057777_GA_G / 9_33798019_A_G
165	ZNF367_1	226_GSK1070916_2	mitosis	12_48679260_CA_C
166	CAV2_3	305_TPCA-1_3	other	12_6952191_A_C / 1_24074187_A_G / 2_68818005_T_G
167	PRKAR2A_5	175_PAC-1_2	apop	13_37746457_TAA_TA / 7_73465568_GA_G / 7_77937691_AT_A / 12_107746489_GT_G / 6_136108863_GA_G
168	CDH3_1	344_THZ-2-49_3	cell_cyc	1_24074187_A_G
169	PCYOX1L_1	271_VNLG / 124_3	chromatin	5_122946014_G_GT
170	RNF13_1	1054_Palbociclib_2	cell_cyc	10_69097096_G_A
171	CD7_2	205_Avagacestat_2	other	5_111103810_A_G / 5_111118983_A_G
172	ZDHHC20_2	190_Bleomycin_1	DNArep	21_38451144_T_G / 11_47588455_A_C
173	LGALS3_1	211_TL-2-105_3	erk_mapk	20_47169235_T_C
174	FANCD2_1	1054_Palbociclib_2	cell_cyc	5_161895646_GT_G
175	TLX2_1	344_THZ-2-49_3	cell_cyc	1_157833087_T_C
176	IFT122_1	1054_Palbociclib_2	cell_cyc	9_33798019_A_G
177	ZNF423_5	175_PAC-1_2	apop	3_9977055_TA_T / 7_77937691_AT_A / 21_32744756_GA_G / 11_63382198_CA_C / 9_120989554_CT_C
178	KDELR1_2	185_Linsitinib_2	igfr	17_62447686_C_T / X_49304797_C_G
179	UFM1_1	282_Pelitinib_2	egfr	8_7811967_A_G
180	ANKRD22_1	281_Alectinib_2	rtk	7_38349808_A_G
181	PLAGL1_3	1526_Refametinib_3	erk_mapk	11_118551711_A_G / 7_93426338_G_A / 16_28902389_G_T
182	ZAP70_5	205_Avagacestat_2	other	13_37746457_TAA_TA / 6_163478762_CT_C / 22_29978883_CT_C / 7_77937691_AT_A / 5_71545270_TA_T
183	OSBPL11_3	1014_Refametinib_2	erk_mapk	17_4896602_C_T / 10_122336546_A_C / 10_122336520_T_C
184	TSPAN7_2	205_Avagacestat_2	other	6_152444591_GA_G / 2_210663103_GTT_GT
185	SPAG7_1	1047_Nutlin-3a (-) _ 2	p53	20_63968004_C_T
186	ABCB10_1	1014_Refametinib_2	erk_mapk	3_52786995_A_G
187	WDR83_4	1236_UNC0638_3	chromatin	16_57460490_GA_G / 14_103670339_GT_G / 1_225147359_GT_G / 16_30280420_GA_G
188	SLC25A29_5	226_GSK1070916_2	mitosis	12_25215659_AT_A / 5_70067144_CA_C / 21_32744756_GA_G / 11_63382198_CA_C / 7_28494775_GT_G
189	SGPP1_1	1526_Refametinib_3	erk_mapk	1_153645034_CT_C
190	CD59_1	271_VNLG / 124_3	chromatin	13_23593366_T_A
191	MRPS21_5	1011_Navitoclax_2	apop	1_148124171_A_G / 1_247841358_T_G / 3_197622346_A_C / 7_100884179_T_G / 11_72220933_A_C
192	ILF2_1	257_NPK76-II-72-1_3	mitosis	19_13993876_CT_C
193	NRM_1	1011_Navitoclax_2	apop	11_4082830_A_C
194	FEM1C_1	1378_Bleomycin (50uM) _1	DNArep	1_15443607_G_A
195	PRCP_1	190_Bleomycin_1	DNArep	3_53179641_T_C
196	P4HB_1	1526_Refametinib_3	erk_mapk	2_71427045_G_A
197	CD44_1	1498_Selumetinib_2	erk_mapk	8_132137720_G_A
198	DCTN4_1	249_Cabozantinib_1	rtk	X_3271895_G_A
199	YIPF5_1	275_I-BET-762_3	chromatin	18_63655761_T_C
200	AGPAT2_1	1526_Refametinib_3	erk_mapk	21_25714604_C_A
201	FAM136A_1	1032_Afatinib_1	egfr	16_50711362_A_C
202	TSPAN32_5	271_VNLG / 124_3	chromatin	22_45399045_C_A / 22_45383455_A_G / 22_45322160_A_G / 4_147906782_T_C / 9_32472897_A_G
203	PLA2G16_1	261_TL-1-85_3	other	11_71605554_A_C
204	MET_2	196_Phenformin_3	metabol	11_71605554_A_C / 19_39902109_T_G
205	TMEM97_1	281_Alectinib_2	rtk	2_113939939_A_G
206	ZNF839_1	176_IPA-3_3	cytoskeleton	10_70301448_T_G
207	ERMAP_4	1526_Refametinib_3	erk_mapk	4_25662622_G_A / 2_160137837_C_T / 10_111079134_C_A / 2_160138253_A_G
208	TMEM150A_1	1014_Refametinib_2	erk_mapk	10_88602550_CT_C
209	PDIA5_1	1526_Refametinib_3	erk_mapk	11_18534402_T_C
210	CLIP1_3	1378_Bleomycin (50uM) _1	DNArep	11_24976472_CTGTT_C / 7_1155657_T_TC / 7_1092820_C_T
211	NUDT2_1	55_A-770041_3	other	14_94592125_A_C
212	SMYD2_1	134_Etoposide_1	DNArep	6_26443625_C_A
213	TMPO_1	203_BMS-345541_3	other	10_69097096_G_A
214	ZC4H2_5	226_GSK1070916_2	mitosis	19_1057777_GA_G / 13_91728769_CA_C / 13_24781827_GTT_GT / 16_30280420_GA_G / 7_77937691_AT_A
215	TXLNB_1	1014_Refametinib_2	erk_mapk	20_56366031_C_T
216	CHID1_3	1014_Refametinib_2	erk_mapk	15_78939184_A_AG / 15_78922969_A_C / 1_53250744_G_A
217	TBXAS1_2	1526_Refametinib_3	erk_mapk	1_13104901_G_A / 1_13116020_T_C
218	KLHL25_5	226_GSK1070916_2	mitosis	12_48679260_CA_C / 3_129433338_GT_G / 13_97982483_AT_A / 6_70861991_TA_T / 6_43525297_GT_G
219	CSF3R_5	277_Linifanib_2	rtk	16_57082546_T_C / 9_137986862_A_C / 16_57081660_C_T / 17_7771466_C_T / 17_7801487_C_G
220	SEPHS1_1	182_Obatoclax Mesylate_2	apop	2_232087433_CT_C
221	TRAT1_3	205_Avagacestat_2	other	10_67956845_TA_T / 20_47180038_AT_A / 16_84013157_C_T
222	BET1_1	224_AS605240_3	pi3k	1_1638657_A_G
223	ZNF238_1	1026_Tanespimycin_2	other	2_151617472_C_A
224	BST1_1	1014_Refametinib_2	erk_mapk	3_75338856_G_A
225	CITED4_1	1014_Refametinib_2	erk_mapk	3_75338856_G_A

Results of verification of biomarker responsiveness to blood cancer drugs

No.	FRH	Var_Exp (pval)	Var_Drug (pval)	Exp_Drug (pval)	Ave_VarDrug (pval)	Rank
One	MYB_5	2.44E-11	2.33E-06 / 2.99E-05 / 9.07E-05 / 0.000162263 / 0.000181347 / 0.000222215 / 0.00035849 / 0.000514476 / 0.000545979 / 0.000674184 / 0.000765635 / 0.000770681 / 0.001809532 / 0.001834875 / 0.002399212 / 0.002524974 / 0.002550614 / 0.003470781 / 0.0036125986 / 0.006467757 / 0.006664862 / 0.007101459 / 0.009131449 / 0.009396282	9.43E-05 / 1.18E-09 / 0.000534893 / 1.91E-08 / 2.60E-05 / 2.14E-05 / 0.178381086 / 3.59E-08 / 0.002198223 / 5.01E-09 / 6.92E-07 / 0.003563123 / 2.90E -06 / 0.0012215 / 4.76E-07 / 5.58E-05 / 0.04742754 / 0.011052464 / 0.001638122 / 0.028671936 / 0.334605149 / 2.70E-05 / 0.120451258 / 0.000163666 / 6.58E-06 / 0.028639924	2.70E-03	26
2	CCND3_2	0.0000000001	4.077045608756939e-05 / 0.00024222551880903305 / 0.001033946011968038 / 0.007738992794998014 / 0.0011591447239658929 / 0.00039912025376145785 / 0.02164918938012539 / 6.767691357801751e-06 / 0.000284832520137907 / 0.012017653306794376 / 0.000245369282796154154	1.3348349963172225e-09 / 2.806907767463066e-08 / 1.0352538568715997e-07 / 1.8603881635236497e-07 / 1.1627237502541528e-07 / 3.1401583771073866e-07 / 1.4513640953107782e-06 / 1.658411377465063e-05 / 3.7392462899431575 7.270726435772972e-07 / 1.8069518974781594e-07 / 9.210108427954504e-07	0.003924411	13
3	CLEC11A_2	0.0000000001	0.0005697783607490941 / 0.014056110467957862 / 0.0041011587330335945 / 0.011850911896821052 / 0.0009698603317938078 / 0.04207757694014471 / 0.0027388104840193185 / 0.00017246675352488265 / 0.03592273895483884 / 0.03175705986170069	2.242207521501935e-07 / 8.305985309487528e-07 / 4.8336013623637535e-06 / 9.846343563173533e-08 / 6.35432916630242e-05 / 4.269555689878972e-05 / 8.205338044521348e-05 / 2.020761222821706e-05 / 3.783085835895955e-05554 1.84820	0.014421647	10
4	SLFN11_1	0.0000014885	2.058410044027094e-07 / 3.2782204810649745e-06 / 0.0004160871569071042 / 6.63292779378419e-05 / 0.006637671888814827 / 0.0022180912856278046 / 0.018399047195112327 / 0.008405657307724725 / 6.561891568628848e-09	2.149510966621969e-13 / 1.511769414105504e-12 / 5.5112514063494236e-11 / 1.4108104414924931e-11 / 2.0143854426093352e-07 / 4.658955213551342e-08 / 8.06522811486229e-08 / 7.925927909364347e-07 / 2.303130551346628e-06	0.004016264	9
5	GLUL_1	0.0000002831	0.00023185717108361177 / 0.006750424182996093 / 0.0002804552471714009 / 0.0005780064318768233 / 0.013252364717981309 / 1.0437921127925209e-05 / 0.0007062900199205474	4.534423217653711e-06 / 3.2067677278063803e-07 / 1.3129666358688659e-07 / 2.6699938480633866e-07 / 2.004464466602968e-06 / 0.00014802121084993243 / 7.828884449821822e-06	0.003115691	7
6	ARRB1_1	0.0000033954	0.0002804552471714009 / 0.0005780064318768233 / 0.010567003405101198 / 0.014937099801101831 / 0.01674887186117834 / 1.0437921127925209e-05 / 0.00023185717108361177	1.4696888618625038e-06 / 3.112710641578339e-05 / 1.247822961432111e-06 / 3.477116300776317e-06 / 0.00011575707789856708 / 0.0008336548513620248 / 0.0016450159858039666	0.00619339	7
7	UBASH3B_1	0.0000018468	0.0002995789665935157 / 0.0040572780204219784 / 0.005622638162586019 / 0.0058415461692228185 / 0.012034946659617903 / 0.021088961594331778 / 0.01327523933544239	4.724411278108721e-08 / 4.074534670810025e-07 / 3.742229484811863e-08 / 1.929959476498321e-06 / 9.208079400238424e-07 / 1.5168095717056432e-05 / 0.00010044442526903786	0.008888598	7
8	TNFRSF1A_2	0.0000000156	0.006712933497164321 / 0.00734125603680501 / 0.03443695791574148 / 0.018289424799019176 / 0.0009354534478970254 / 0.03357668476840166 / 0.007912796162920774	4.5437268485007956e-12 / 9.62085159236817e-09 / 5.689408914135723e-10 / 2.0274308401802066e-09 / 8.235496674010025e-08 / 1.2678212837654556e-05 / 8.896726535766315e-06	0.015600787	7
9	FLT3_1	0.0000001451	0.003147802426563143 / 0.04222939169807093 / 0.02231188189092723 / 0.029744514791248327 / 0.028609215461963253 / 0.014219370494597181 / 0.014883090519715167	0.0012185301703030475 / 0.0002548917231763184 / 0.010959181924780034 / 2.4351732992736147e-06 / 5.5554978038046984e-05 / 0.0009499267638480247 / 0.013113311745609578	0.02216361	7
10	TAF3_1	0.0000001041	1.571192550615105e-05 / 1.941083369182502e-05 / 0.0005612205331984135 / 0.0014877407788245077 / 5.841226151846549e-05 / 0.0007872693710314749	1.0270513426028016e-06 / 2.275418199134362e-06 / 5.376973880229442e-07 / 5.440513967426541e-05 / 4.007754879249793e-05 / 9.814569472587485e-06	0.000488294	6
11	RNF169_1	0.0000003217	0.01436512323945228 / 0.0006014109163865767 / 0.0001378888342129313 / 0.0002929996205947111 / 0.007650609737897124 / 0.0005428574293301743	0.0010596490798711214 / 0.00033866528188749375 / 5.121947955378021e-05 / 5.927440166657884e-05 / 6.948929572951347e-06 / 2.3120988018089485e-05	0.003931815	6
12	AGTRAP_1	0.0000023662	0.0027034438550029654 / 0.0016457734962318454 / 0.014533062562870484 / 0.02599605804689892 / 0.0024801934991487765 / 0.009546895754403102	1.646452812514797e-07 / 5.834785414810817e-09 / 2.228307124314093e-06 / 5.569491755748062e-05 / 2.3571084667936895e-07 / 0.0003782361834351102	0.009484238	6
13	DDX60L_1	0.0000004163	0.008667427627946265 / 0.006966556160504672 / 0.002473974378703085 / 0.016468758578796875 / 0.004255262005017205 / 0.025751753175331515	2.1944492060454965e-10 / 8.933493156895685e-11 / 2.0506277272462366e-08 / 1.215047380695114e-10 / 7.747481723739867e-10 / 1.3299778330505356e-06	0.010763955	6
14	MARCH9_1	0.0000028687	0.008696629436037122 / 0.015715958080688867 / 0.014693978334844182 / 0.007641325545186426 / 0.01903807829299923 / 0.02673662083221299	2.0837934472912685e-10 / 3.483396562503217e-08 / 4.9563854817943744e-06 / 1.1230784085451434e-07 / 4.956418832931685e-07 / 6.827219227535627e-05	0.015420432	6
15	OSBPL5_1	0.0000008435	0.0261982361091171 / 0.030902579554522257 / 0.005200674803908244 / 0.01749894538092688 / 0.0006032976474312159 / 0.02092310744702267	5.453427993682317e-09 / 3.766985952770836e-07 / 1.2761924650567061e-06 / 7.72434990386913e-06 / 1.4070385044464016e-05 / 3.4211990088426983e-05	0.016887807	6
16	ZNF22_1	0.0003669254	0.004371760349727022 / 0.0099226754908213 / 0.010321671240407263 / 0.011325776736179346 / 0.044537859106021475 / 0.025680963996521974	2.5184177279829715e-06 / 1.636959244332829e-05 / 9.28253424535522e-06 / 2.0181236604145942e-05 / 1.6154147530836813e-08 / 1.1540056394143666e-05	0.017693451	6
17	DGAT1_3	0.0000000002	0.003920312673863002 / 0.033716279024290426 / 0.028856747132498983 / 0.001891302386162808 / 0.0334381808514423 / 0.04828281984464098	8.140369229025295e-09 / 5.289386858277019e-09 / 3.985757315136653e-06 / 1.144807405715584e-06 / 1.0254993066544188e-07 / 5.67274705848272e-07	0.025017607	6
18	ORMDL3_2	0.0000000026	0.0001300233129794514 / 0.00012978314275476224 / 0.0012778350943993954 / 0.0029565776361184853 / 7.156767789831989e-05	4.677646164059941e-05 / 1.7503293191137602e-05 / 0.00021751510293843788 / 0.0007155675311678111 / 0.0004230167122498104	0.000913157	5
19	ROPN1L_2	0.0000000992	0.0018394467371983382 / 0.00913487358238157 / 0.0049023855394268795 / 0.026316021782540434 / 0.0004368255106696828	1.65748500527577e-06 / 2.69948847247789e-06 / 3.4467469699377065e-06 / 8.914027666915662e-05 / 4.187857920242108e-05	0.008525911	5
20	MSI2_1	0.0000007794	0.0002529667144490502 / 0.00036391652177154756 / 0.02345731242786629 / 0.019126121819567174 / 0.0033080493995101515	7.391397953437064e-07 / 4.9426454303194644e-08 / 1.2647772425190535e-05 / 1.2578560206261788e-05 / 0.0003891280853340393	0.009301673	5
21	PSTPIP2_2	0.0000011641	0.01858959254693148 / 0.0057681381434131025 / 0.015399266745073165 / 0.01166420660727075 / 0.004242395710111552	6.507094545128767e-09 / 1.7105362633772053e-06 / 8.11163443332903e-09 / 8.384249213928925e-09 / 2.7206056643566975e-06	0.01113272	5
22	MYL6B_1	0.0000017698	0.013119151423196779 / 0.012200296617999914 / 0.02306053904486267 / 0.011416714879054282 / 0.01303162671001627	1.3311228115309853e-10 / 2.1189280513945988e-08 / 2.608386936275246e-06 / 4.4163387400701993e-07 / 1.2403225638581886e-06	0.014565666	5
23	LPAR6_2	0.0000010413	0.04483307027122483 / 0.016219042044394588 / 0.016746868284220093 / 0.00486964278014844 / 0.011545690725925754	3.55398091991154e-07 / 3.727072342882139e-06 / 8.612792966957608e-06 / 2.5049632841227237e-05 / 0.0002242378619733357	0.018842863	5
24	RIPK2_5	0.0000090083	0.02265948210195236 / 0.035801285983055375 / 0.013949514732498905 / 0.03916661845542834 / 0.010906005384287334	2.1349289386986835e-07 / 6.970901169252273e-06 / 0.0001261364550401567 / 0.000139252106012186 / 0.0001754023039229962	0.024496581	5
25	KIF15_1	0.0000003279	0.0001767131207877772 / 0.0020841717587245586 / 0.004354818985686167 / 0.003594625784570769	3.8166356839184545e-08 / 7.55812749192087e-08 / 8.424093350919768e-09 / 1.7417317886126239e-06	0.002552582	4
26	ATP11A_2	0.0000000003	0.0020192776408069777 / 0.0014905987749008023 / 0.013592511172070427 / 0.011492354840434907	3.060704654994384e-08 / 1.3622595470762118e-06 / 1.1997422693515186e-05 / 2.3355709465331877e-05	0.007148686	4
27	ZYX_1_9	0.0002544084	0.018753885801507886 / 0.005311083771261927 / 0.006409025340802752 / 0.005160774238426144	4.184364793482633e-08 / 2.790592162598525e-08 / 4.0166122353119465e-05 / 1.8565339769963503e-05	0.008908692	4
28	SNRPG_5_5	0.0000089357	0.007921660193554354 / 0.02167583393151509 / 0.010388347521304256 / 0.004658316663498735	3.551868821203453e-05 / 0.00013168055697875434 / 6.548534863709185e-06 / 0.0005681263502070304	0.01116104	4
29	RABGAP1_4_4	0.0000000240	9.003720907011053e-06 / 3.3390115236034044e-05 / 0.00010269468011156112 / 0.047149137178743444	2.8234052288359836e-11 / 1.0277712264139365e-09 / 4.49119651999139e-09 / 2.1963432700833613e-06	0.011823556	4
30	AEBP1_5_4	0.0000000706	0.036562724183920495 / 0.0028825516275127186 / 0.00160056713944595 / 0.011492031900646014	1.9554526130426222e-07 / 1.552879261624138e-05 / 4.179984189724783e-07 / 8.30585388888977e-05	0.013134469	4
31	HNRNPA0_5_7	0.0000000001	0.02460227458303824 / 0.004665409573481128 / 0.030772288525987988 / 0.001787886444312416	6.020361445492525e-07 / 1.741544026523412e-07 / 5.73570311140249e-07 / 6.770166211380507e-06	0.015456965	4
32	PVRL2_1_15	0.0040605369	0.009602522264793944 / 0.009289808589253353 / 0.018424979456259774 / 0.024543614212947564	1.124934929019874e-11 / 8.232216311317465e-10 / 1.9664830084576235e-07 / 4.469619906576272e-09	0.015465231	4
33	KIAA1377_1_4	0.0000081593	0.018039249363489208 / 0.024808081702847627 / 0.015360074710325671 / 0.006240332233062281	7.596479317713833e-09 / 6.788792995710976e-08 / 1.35168996872219e-07 / 2.1659140645524504e-08	0.016111935	4
34	THEM4_5_4	0.0000000056	0.007883092210604252 / 0.045211602878352866 / 0.013149940565499176 / 0.005780083414189651	4.830559480901911e-08 / 7.6434613644282e-08 / 1.0166377279715499e-05 / 5.88015987182058e-07	0.01800618	4
35	RBM15B_4_4	0.0000007681	0.0009381311035088946 / 0.03970456788745093 / 0.028253326379734534 / 0.006515747132785524	1.3038025544377534e-07 / 2.059062830566604e-07 / 4.983244116392506e-06 / 6.51433835861991e-05	0.018852943	4
36	C10orf11_1_7	0.0003082937	0.02543028371249526 / 0.04598785527902361 / 0.015049388659828227 / 0.023622920144404418	7.259417399792894e-07 / 7.365037376695162e-06 / 2.047194651689395e-05 / 0.0002797495873085723	0.027522612	4
37	NSMAF_1_7	0.0000032686	0.022251914845713937 / 0.04748951355240249 / 0.048345822890961225 / 0.01793479538407506	2.9254934132272395e-07 / 6.623060722446782e-06 / 5.831321946385646e-07 / 0.0022213483241615155	0.034005512	4
38	FRAT2_2_9	0.0000008562	0.0469875036346009 / 0.03110964092628252 / 0.028109447152411662 / 0.04417620834797813	3.3044879183409916e-06 / 9.1345152872844e-06 / 8.429737657625968e-06 / 1.855611509886761e-05	0.0375957	4
39	LRPAP1_2_3	0.0000000010	5.8572126941774705e-06 / 3.043966989607747e-06 / 4.7114539866525214e-06	1.9971265139787018e-07 / 8.389633993572189e-07 / 4.782132344940121e-05	4.53754E-06	3
40	PRAM1_3_3	0.0000000000	7.723544457794067e-05 / 0.00043689278876896613 / 6.689338676878303e-05	0.00010570433563924172 / 0.007095334821012586 / 0.00012642089180450603	0.000193674	3
41	RAG1_2_3	0.0000000001	0.0005257240065993557 / 0.0002394716728524391 / 0.0025629535017791943	5.592836211795487e-07 / 4.514859891307818e-06 / 0.00031448434878023827	0.001109383	3
42	CARHSP1_2_3	0.0000000916	7.622564649516217e-05 / 0.0009833215694022874 / 0.0024720664729962283	2.124059305243635e-07 / 0.00011446446711497937 / 7.575581180621143e-05	0.001177205	3
43	MBLAC1_1_3	0.0000002897	0.001629254700856046 / 0.007145353467565649 / 0.003740996699493107	2.6740655179081655e-06 / 5.483995787755592e-05 / 9.450515390044369e-06	0.004171868	3
44	RAG2_3_4	0.0000000033	0.006629188877801916 / 0.0035201246516142408 / 0.007903236560929908	9.394932445113252e-06 / 6.847563888114024e-07 / 3.436655016403447e-06	0.006017517	3
45	HNMT_1_4	0.0000109002	0.01445558317701132 / 0.002106973677295091 / 0.0051161594672994425	0.0009692764104023793 / 0.003012779171399397 / 0.0024376724564066005	0.007226239	3
46	KCTD7_2_5	0.0000002604	0.020616294446739954 / 0.00021206125966908608 / 0.0009033836310563283	8.885033400689205e-08 / 2.389820509715415e-08 / 1.552864015973841e-06	0.007243913	3
47	GSN_1_6	0.0000451573	0.018753885801507886 / 0.005160774238426144 / 0.005311083771261927	1.4722017530591616e-07 / 2.9874753250046506e-06 / 0.0002124927996391344	0.009741915	3
48	CBFB_2_5	0.0000000001	0.003275583453177208 / 0.011330483320304221 / 0.01982909497763039	2.0245259136355526e-08 / 1.1456344413276593e-07 / 2.816265834361234e-06	0.011478387	3
49	FBXO33_1_4	0.0000001371	0.0023176777492038073 / 0.0077384325604461434 / 0.028530012205593615	1.072142034599158e-06 / 5.345226496779758e-06 / 8.792028909123797e-05	0.012862041	3
50	ZBED4_2_4	0.0000000002	0.00012909510564440324 / 0.027672452276552212 / 0.021025463475859662	9.434784549401446e-08 / 1.0143923768921633e-06 / 4.495391600951897e-06	0.01627567	3
51	COPS8_5_6	0.0000043601	0.0031977499264920816 / 0.0058949672009652055 / 0.0415421191636228	6.858069673230018e-10 / 4.518917447441741e-08 / 2.2871232096910657e-06	0.016878279	3
52	ISG20_1_12	0.0000001188	0.035870034304549374 / 0.006915099173258228 / 0.011599763066790982	4.0742030661470875e-09 / 3.5704180408306135e-05 / 2.6235380954232833e-06	0.018128299	3
53	LGALS12_3_4	0.0000000247	0.003840056352113353 / 0.04492920892897124 / 0.006327629664955956	1.3156520171567348e-06 / 2.8564954858549742e-05 / 1.2400627667338633e-05	0.018365632	3
54	SNRNP48_5_3	0.0000000018	0.010494026299769539 / 0.043808945731610247 / 0.0014402699590059412	2.99777252070361e-08 / 9.372440209809473e-07 / 1.6303080292790598e-06	0.018581081	3
55	VPS37C_3_4	0.0000000002	0.015575058031697179 / 0.022954263288630178 / 0.019211836869592394	1.1893807531811264e-07 / 4.436107889122841e-07 / 2.596755422338286e-05	0.019247053	3
56	ATP6V0A1_1_3	0.0000019232	0.000953280912166266 / 0.048984014938993056 / 0.009090139199551346	3.96290085102306e-06 / 5.2636828189880915e-05 / 2.713261376319351e-06	0.019675812	3
57	HEATR5A_5_6	0.0000002878	0.007823565564916568 / 0.0292814900476121 / 0.02260169832848745	8.824452322000626e-09 / 8.736451088889874e-07 / 3.993788450977646e-06	0.019902251	3
58	ENG_2_8	0.0000000000	0.03439309599730442 / 0.026001527500775657 / 0.0004074623263257791	3.7930066913887975e-05 / 2.6178770339186957e-06 / 3.208634906990993e-05	0.020267362	3
59	USF1_5_7	0.0000000001	0.021841208862304992 / 0.020652548829715695 / 0.021917069763045867	7.175376098186409e-08 / 2.6998472948345092e-08 / 3.909927527606591e-07	0.021470276	3
60	GRB10_2_11	0.0000185139	0.01872961470434043 / 0.02675787024949966 / 0.02145205112846333	1.2669785337002742e-06 / 3.145604382649769e-05 / 0.003268778879566519	0.022313179	3
61	ZNF415_2_4	0.0000000549	0.034523433022212606 / 0.002626392249292539 / 0.03171232908110631	0.00011739915632689058 / 0.00032821497481615343 / 0.0006546049761514156	0.022954051	3
62	DMTF1_1_4	0.0000031099	0.014324360736687866 / 0.014925670621200341 / 0.04696641107757261	1.4288355402449756e-08 / 1.4596250772642315e-06 / 5.309179790067734e-07	0.025405481	3
63	MSL2_4_5	0.0000015252	0.037843536087373564 / 0.028245718557519638 / 0.010417492228432875	8.258866166846628e-08 / 0.0002798921759421857 / 1.2286864638985527e-05	0.025502249	3
64	ATP7B_2_6	0.0000857095	0.019438518423424804 / 0.04009632870085458 / 0.019672456709775226	0.005743135091223456 / 0.0021129104763862407 / 0.00504181900162891	0.026402435	3
65	MANBAL_1_5	0.0010263664	0.04759200231032889 / 0.013410196167242377 / 0.021153975401583373	0.0006029756140517701 / 0.00041293727100713963 / 0.0005679619453748995	0.027385391	3
66	STOX1_1_3	0.0000006884	0.03863925234050396 / 0.03290414475660668 / 0.03755706426028869	3.498492394676035e-07 / 3.760551753407323e-07 / 2.1838711309964997e-05	0.03636682	3
67	PRKCB_2_4	0.0036722126	0.03636552435344791 / 0.0455393445167841 / 0.028719427176232087	0.0017342974389574256 / 0.0002954473217666082 / 0.0019265906505422808	0.036874765	3
68	PNPLA8_3_5	0.0007762216	0.042906002207961834 / 0.03376346011476386 / 0.04533268492631154	1.8682120741176118e-07 / 3.889932908773882e-08 / 9.103372671114004e-06	0.040667382	3
69	ACCS_3_2	0.0000000228	0.001351396866557077 / 0.0010059530260990539	4.958979360917343e-05 / 0.0023766001705639063	0.001178675	2
70	BANP_1_2	0.0000005192	0.0019949596708715915 / 0.0016405254782622762	1.8954349923575262e-08 / 2.9663347375425656e-07	0.001817743	2
71	ARID1A_2_3	0.0000370373	0.0002225245598561803 / 0.003462048449780649	2.8835181082720374e-06 / 8.852299874117299e-06	0.001842287	2
72	ELOVL5_1_4	0.0000080768	0.0039737550720910855 / 0.0005677614392890738	1.767738685972929e-05 / 5.339450136972672e-05	0.002270758	2
73	N4BP2_5_2	0.0000006959	0.0015260933937112297 / 0.0030693630789256784	8.782349802931962e-08 / 1.8514757097012648e-06	0.002297728	2
74	LIMS2_5_3	0.0000000063	0.0016929672723561087 / 0.008211724439767342	0.0016526205911910397 / 0.00010998980798238088	0.004952346	2
75	DPCD_1_2	0.0001195622	0.010348808383695646 / 0.0010576116241639605	3.4139161518097934e-06 / 5.8072556519062024e-05	0.00570321	2
76	KATNB1_5_2	0.0000003099	0.0019502509185472647 / 0.011870363561574568	6.469316636849928e-07 / 1.4319474206641112e-06	0.006910307	2
77	RBM18_1_3	0.0000183263	0.01202180554894753 / 0.0035996788619062025	2.314655750329529e-05 / 1.6273301545995376e-05	0.007810742	2
78	EWSR1_1_2	0.0000001571	0.012034946659617903 / 0.0040572780204219784	4.353930633746647e-07 / 1.4940958130887165e-07	0.008046112	2
79	SDC4_1_5	0.0234952285	0.012910722002948388 / 0.003241368623522047	0.0023789084931403904 / 2.15445169218155e-05	0.008076045	2
80	LCK_5_3	0.0000000635	0.008161592461102153 / 0.008111725160704844	5.0045516393587565e-08 / 2.5329814927720417e-06	0.008136659	2
81	GNA15_1_9	0.0000088925	0.0025023165322416653 / 0.015816246241733566	1.2297735264773097e-09 / 2.212465069137835e-05	0.009159281	2
82	S1PR2_2_8	0.0000000000	0.019132559438094155 / 3.0373671784422295e-05	8.259862596669298e-06 / 3.850434675370876e-06	0.009581467	2
83	SOX4_2_2	0.0000001046	0.0027896864342722566 / 0.018314702453390137	1.3593400126131383e-06 / 3.4858545482237707e-06	0.010552194	2
84	MPP1_1_19	0.0000010744	0.0025023165322416653 / 0.019031746930740782	6.468408975112741e-07 / 4.501092888023762e-06	0.010767032	2
85	TRIM26_1_5	0.0000259348	0.005311083771261927 / 0.018753885801507886	2.1060691141971387e-05 / 8.874237350648491e-05	0.012032485	2
86	NRN1_2_2	0.0000003469	0.011538246690417763 / 0.013237230739493226	4.568675707352792e-05 / 3.561238367689432e-05	0.012387739	2
87	PHACTR2_1_4	0.0000005718	0.023477467429053465 / 0.0031820555262817535	8.883753710042578e-09 / 3.719669014236788e-08	0.013329761	2
88	TRAF3IP2_2_2	0.0000002512	0.0007576193165839696 / 0.027287848272635487	6.910884434287362e-05 / 0.0005161273618227694	0.014022734	2
89	MLF1IP_1_2	0.0000000269	0.01425257865031356 / 0.013908722253004258	2.3242551216769015e-07 / 2.032446141420201e-07	0.01408065	2
90	PELI2_5_7	0.0000007941	0.024350309684056323 / 0.0040259990419718224	1.6694115297250117e-05 / 4.29829826110023e-06	0.014188154	2
91	HNRNPA1L2_1_2	0.0013250663	0.011811366692668503 / 0.01996564314234407	6.032224635469657e-06 / 0.00022917080156904956	0.015888505	2
92	BCL11B_5_3	0.0000002152	0.0010839847636384084 / 0.0314544685608876	1.5333271595229285e-05 / 5.898660325189134e-05	0.016269227	2
93	TTF1_5_6	0.0000000000	0.029170441459925932 / 0.005632866448663831	5.197029616318252e-06 / 3.552041331603543e-05	0.017401654	2
94	SKA3_1_2	0.0000017003	0.02944327994687945 / 0.006711372368467916	7.293595674464534e-07 / 6.073859065512907e-06	0.018077326	2
95	ECI1_1_2	0.0000229019	0.035232086909202764 / 0.004224402787232246	0.0006535889942974735 / 1.0760030207436584e-05	0.019728245	2
96	LAPTM4B_1_8	0.0005057964	0.038858943917955066 / 0.0026332591769253765	8.316897145333996e-07 / 0.0026794799237590664	0.020746102	2
97	C11orf74_4_5	0.0000166404	0.0065634419527186095 / 0.035907170503621015	2.3323526700006173e-07 / 3.9706288089173614e-08	0.021235306	2
98	RNF24_1_12	0.0000007106	0.035870034304549374 / 0.006915099173258228	7.35322340702987e-10 / 2.1643712587488395e-06	0.021392567	2
99	CRB3_1_4	0.0001229934	0.0007511098393260164 / 0.04383341877435241	0.003519521269349817 / 0.00041067349827126156	0.022292264	2
100	CNTROB_5_3	0.0000000247	0.039985574714404205 / 0.006604515441249478	2.807079453207472e-06 / 6.0843943238096606e-06	0.023295045	2
101	KIAA1967_5_2	0.0000000000	0.03731581709317308 / 0.012775853621628915	5.8098057666508814e-05 / 1.4846660294438575e-05	0.025045835	2
102	KRT10_1_3	0.0000036294	0.0026276752303615626 / 0.04816709797976521	2.3292547237816868e-07 / 1.1196213690475162e-05	0.025397387	2
103	VIT_1_2	0.0000022102	0.029787982806896113 / 0.032221265722000465	0.00017866575515019837 / 0.0002927226669085562	0.031004624	2
104	TMEM173_2_7	0.0000013775	0.04752560036471882 / 0.021645143900361517	9.96917291837022e-10 / 3.7449827724309687e-05	0.034585372	2
105	SGCB_1_3	0.0000001520	0.04565488150522094 / 0.02362203677270414	1.1745686994413256e-07 / 2.146978330026032e-06	0.034638459	2
106	DTD1_3_4	0.0000046923	0.04395039131441785 / 0.025938330717151792	2.2711346209436874e-06 / 5.0656566660967563e-05	0.034944361	2
107	DYSF_1_3	0.0000126202	0.0339445086192224 / 0.03749998396549492	1.097257076002153e-06 / 3.4300052428458304e-05	0.035722246	2
108	AP2S1_1_3	0.0000000192	0.04966114977300441 / 0.025208249293274098	9.67952519324101e-06 / 5.812467299823981e-06	0.0374347	2
109	EMILIN2_1_11	0.0000004298	0.035870034304549374 / 0.04080808705746035	3.9151610584341596e-05 / 0.0034531579985310175	0.038339061	2
110	SLC38A1_1_6	0.0000051639	0.04291927548525659 / 0.04100450439141127	0.00021587157297136373 / 7.315015547583871e-06	0.04196189	2
111	SGSM2_4_1	0.0000000000	1.8562520247073517e-06	1.2613994263920118e-05	1.85625E-06	One
112	ADAM15_1_1	0.0000043982	2.1108944769046428e-05	4.681342411309229e-05	2.11089E-05	One
113	JPH1_2_1	0.0000000278	7.575574348900015e-05	3.941680513177924e-06	7.57557E-05	One
114	S100A8_1_3	0.0000014212	0.00016898721560974943	0.00029401372690121037	0.000168987	One
115	SQSTM1_2_1	0.0000005259	0.00017867345021532058	9.669186962307088e-08	0.000178673	One
116	ANXA2_1_1	0.0002075934	0.0006183619071556604	6.009170462268738e-07	0.000618362	One
117	CMBL_1_2	0.0000903757	0.0006632986409284882	0.0009716339098724625	0.000663299	One
118	CABLES2_1_1	0.0000005356	0.0009735838558541434	1.5864345356463386e-06	0.000973584	One
119	NDST3_2_1	0.0001935195	0.0013385816312795275	0.004242951596879371	0.001338582	One
120	LMNA_1_1	0.0001346708	0.0013680275764369084	1.8919816110190497e-07	0.001368028	One
121	SP1_5_1	0.0000000097	0.0016246578528363023	0.003568784039880526	0.001624658	One
122	CDCA7_1_2	0.0000002357	0.001651752731778548	3.2201603349527115e-08	0.001651753	One
123	NFYB_1_1	0.0000079306	0.001651752731778548	2.9900676055211447e-06	0.001651753	One
124	SLFN5_2_1	0.0000000019	0.0019030049715582106	1.6941578744438862e-06	0.001903005	One
125	CREG1_3_1	0.0000000008	0.002054415410594919	7.20016447767814e-08	0.002054415	One
126	DAD1_1_1	0.0000006548	0.0023044700596710713	2.075870685180039e-05	0.00230447	One
127	SURF4_1_4	0.0001169460	0.0023462063828761834	2.694050289871364e-06	0.002346206	One
128	CDK6_1_1	0.0000006851	0.0025023165322416653	4.988905197611986e-08	0.002502317	One
129	TBCD_5_1	0.0000000036	0.002561276140915946	2.9892584316614904e-05	0.002561276	One
130	FLRT3_1_1	0.0002800458	0.002583315109010803	5.49167223817782e-07	0.002583315	One
131	FUCA2_2_1	0.0000025095	0.002692404935612982	1.2127488828322545e-08	0.002692405	One
132	MAPK7_1_1	0.0000080829	0.0027910840567973052	3.572472659968713e-06	0.002791084	One
133	IER3_1_1	0.0000013686	0.003048257034885675	4.950876200499383e-07	0.003048257	One
134	U2AF1_1_1	0.0000711501	0.0034457838678580263	4.61837154254303e-05	0.003445784	One
135	PLA2G12A_1_3	0.0000038708	0.0037441061510198473	2.729672667763293e-06	0.003744106	One
136	CBX2_2_1	0.0000000018	0.004184305915812207	5.9615623663426e-06	0.004184306	One
137	MGAT4A_5_1	0.0000000380	0.004222683731586138	8.335124351148404e-06	0.004222684	One
138	STARD10_1_1	0.0000111851	0.004248732743058664	1.7842777216078496e-05	0.004248733	One
139	CSRNP2_1_1	0.0006867668	0.004513557106243546	0.0027185421381640293	0.004513557	One
140	DOK2_2_1	0.0000003678	0.004572328568472603	1.1556890898941218e-07	0.004572329	One
141	VOPP1_1_1	0.0000001536	0.004906926404956519	6.909057066591582e-07	0.004906926	One
142	PLOD1_1_1	0.0000003727	0.005173685415892114	3.142318025848709e-07	0.005173685	One
143	C3AR1_1_1	0.0000020129	0.005257465843641482	2.3396828250233102e-05	0.005257466	One
144	CYSLTR1_1_1	0.0000173361	0.005311083771261927	4.033605569704644e-05	0.005311084	One
145	S100A6_1_1	0.0000725809	0.005362813680576461	5.537142752723009e-07	0.005362814	One
146	ZADH2_1_1	0.0000007439	0.005446188106227207	4.5754730268930877e-07	0.005446188	One
147	EXOSC9_5_2	0.0000000031	0.005557108169871316	0.0008987664165136352	0.005557108	One
148	ZC3H4_2_1	0.0000015162	0.0056341770524356806	2.473933719190643e-06	0.005634177	One
149	BARD1_1_2	0.0001823376	0.006165167235416857	1.190027150355448e-06	0.006165167	One
150	MCL1_1_1	0.0000001874	0.007100868378374273	4.0192784636893195e-10	0.007100868	One
151	NINL_3_4	0.0002849953	0.0075283603267041295	0.00041052511652349915	0.00752836	One
152	HYI_5_1	0.0000017676	0.0075586596774093046	1.819350673029577e-06	0.00755866	One
153	USP49_1_1	0.0001312429	0.008755239263851211	3.964656691897526e-06	0.008755239	One
154	EPB41_1_3	0.0001006328	0.009034882970510456	0.00013511214683115084	0.009034883	One
155	NFAM1_1_1	0.0022752255	0.00930978531173234	0.002292669227147625	0.009309785	One
156	SIVA1_5_1	0.0000000190	0.00976422285866606	7.911319869760405e-07	0.009764223	One
157	LRG1_1_2	0.0000001990	0.009927973270752382	2.608540917049233e-06	0.009927973	One
158	TMPRSS15_1	0.0006841749	0.01024047346065129	0.0015664204162032947	0.010240473	One
159	G0S2_1	0.0000299702	0.010257439205265872	8.408868136136204e-05	0.010257439	One
160	PPIP5K2_2	0.0000000004	0.010428331358146754	3.5879660652504166e-05	0.010428331	One
161	AGPAT3_4	0.0000001930	0.012409468524965496	5.951529459390704e-06	0.012409469	One
162	AS3MT_5	0.0000000636	0.012507967443150024	5.2069842035903486e-05	0.012507967	One
163	PIK3R3_1	0.0000004378	0.012693846370002933	1.1134112040621844e-05	0.012693846	One
164	CRY1_2	0.0000000015	0.01273908719327046	1.0364125026792716e-05	0.012739087	One
165	ZNF367_1	0.0000007429	0.012817165427214991	1.6554871434804345e-06	0.012817165	One
166	CAV2_3	0.0000900165	0.013003562519067686	0.0003165314040118799	0.013003563	One
167	PRKAR2A_5	0.0000000095	0.01304625461905942	1.165198476893287e-06	0.013046255	One
168	CDH3_1	0.0045171197	0.013410196167242377	0.0007156791563689302	0.013410196	One
169	PCYOX1L_1	0.0000134838	0.013753446987297501	1.9648507707958793e-05	0.013753447	One
170	RNF13_1	0.0000015479	0.01425257865031356	1.4173074929245687e-06	0.014252579	One
171	CD7_2	0.0000009350	0.01439564075722508	7.429143195372626e-05	0.014395641	One
172	ZDHHC20_2	0.0001740391	0.015206312141533855	4.602813943558735e-05	0.015206312	One
173	LGALS3_1	0.0000060213	0.015392940222320921	1.0628836539660367e-05	0.01539294	One
174	FANCD2_1	0.0000121545	0.015451637722969586	1.8831841564871015e-06	0.015451638	One
175	TLX2_1	0.0000038270	0.01579251142156246	0.00030858470095783614	0.015792511	One
176	IFT122_1	0.0000002512	0.015816246241733566	1.0290413092804304e-06	0.015816246	One
177	ZNF423_5	0.0000000005	0.01687645691903394	6.82889444974133e-05	0.016876457	One
178	KDELR1_2	0.0000093509	0.017039557735435966	0.0033303362491578807	0.017039558	One
179	UFM1_1	0.0000305210	0.01740310378263097	1.2418583024568846e-07	0.017403104	One
180	ANKRD22_1	0.0041854861	0.018007630833331033	0.03752163881197765	0.018007631	One
181	PLAGL1_3	0.0000021368	0.018069182178099105	3.851073571966146e-09	0.018069182	One
182	ZAP70_5	0.0000000009	0.018364208164662808	6.653729445177915e-06	0.018364208	One
183	OSBPL11_3	0.0000067843	0.018433344261519963	9.808098956813373e-09	0.018433344	One
184	TSPAN7_2	0.0004599184	0.018664165174459613	0.0021706260770740027	0.018664165	One
185	SPAG7_1	0.0000103437	0.01887978871098741	3.5786939909329174e-07	0.018879789	One
186	ABCB10_1	0.0000008268	0.019394963522372948	7.395897405399312e-06	0.019394964	One
187	WDR83_4	0.0000057993	0.019553853323608723	0.0007136717421366572	0.019553853	One
188	SLC25A29_5	0.0000000015	0.019638512683722072	9.869448477453816e-08	0.019638513	One
189	SGPP1_1	0.0000025587	0.020929857770881414	2.0298643448524998e-06	0.020929858	One
190	CD59_1	0.0000068828	0.021559533703573927	0.001648922456290617	0.021559534	One
191	MRPS21_5	0.0077373847	0.021700322664243165	9.63985905023122e-07	0.021700323	One
192	ILF2_1	0.0000000252	0.02183529105408133	3.091305085273976e-06	0.021835291	One
193	NRM_1	0.0002687490	0.022253050272657	2.0382718096255757e-09	0.02225305	One
194	FEM1C_1	0.0000014517	0.02227664632042583	8.589759094000804e-06	0.022276646	One
195	PRCP_1	0.0000000056	0.0230304550081597	2.1961723373343916e-07	0.023030455	One
196	P4HB_1	0.0000003568	0.02341318363108619	2.8084943956360846e-10	0.023413184	One
197	CD44_1	0.0000359903	0.023548564177701903	1.6066512112185574e-09	0.023548564	One
198	DCTN4_1	0.0013385549	0.024489122777067992	0.019368696851182407	0.024489123	One
199	YIPF5_1	0.0000060349	0.026730236331654417	1.0541687156357308e-06	0.026730236	One
200	AGPAT2_1	0.0000002107	0.026889530537036167	1.7713923094852022e-07	0.026889531	One
201	FAM136A_1	0.0006422807	0.028051819441664617	0.002488725830315593	0.028051819	One
202	TSPAN32_5	0.0000000000	0.02866197022141713	5.259717320638688e-06	0.02866197	One
203	PLA2G16_1	0.0003081786	0.02897405027367459	2.0665812391610075e-06	0.02897405	One
204	MET_2	0.0000285645	0.030192710022355414	0.00379589859681431	0.03019271	One
205	TMEM97_1	0.0036145788	0.03026262122509119	0.00021306559827421171	0.030262621	One
206	ZNF839_1	0.0000001711	0.030726289078901264	1.5879232684994666e-05	0.030726289	One
207	ERMAP_4	0.0001168108	0.031146240127524386	6.298967979200791e-05	0.03114624	One
208	TMEM150A_1	0.0000043452	0.03197682912178042	1.628398621899164e-05	0.031976829	One
209	PDIA5_1	0.0000034458	0.03351303270628667	2.3191823260124111e-10	0.033513033	One
210	CLIP1_3	0.0000001166	0.03429726403676071	4.469910794620894e-06	0.034297264	One
211	NUDT2_1	0.0000159662	0.034635799638304134	1.3986302087232156e-05	0.0346358	One
212	SMYD2_1	0.0000077856	0.03730228706011286	1.2971961011563423e-05	0.037302287	One
213	TMPO_1	0.0000008966	0.03798708635473315	9.272936461577683e-05	0.037987086	One
214	ZC4H2_5	0.0000000001	0.03821396773041524	3.364502202047952e-05	0.038213968	One
215	TXLNB_1	0.0063084330	0.038858943917955066	3.4406524050829844e-08	0.038858944	One
216	CHID1_3	0.0000000038	0.038921368031173256	1.7696631517095603e-08	0.038921368	One
217	TBXAS1_2	0.0001000498	0.03912053365002339	0.00017683963886805498	0.039120534	One
218	KLHL25_5	0.0000000143	0.04196676056691442	1.7560089108082686e-05	0.041966761	One
219	CSF3R_5	0.0000000304	0.04250513375736285	0.00017631047010437925	0.042505134	One
220	SEPHS1_1	0.0000222248	0.0450636464624055	6.469551154776827e-06	0.045063646	One
221	TRAT1_3	0.0000000000	0.04551857731992099	0.00013370660602496452	0.045518577	One
222	BET1_1	0.0000000254	0.0465608957106569	1.9024554960722768e-07	0.046560896	One
223	ZNF238_1	0.0000006050	0.046847268071909955	7.35354402710928e-05	0.046847268	One
224	BST1_1	0.0000370830	0.04931613832873068	0.0025410513361841546	0.049316138	One
225	CITED4_1	0.0000331218	0.04931613832873068	5.1719881815858375e-05	0.049316138	One

Table 4 lists the FRHs associated with the female cancer drug, and the markers defining the female cancer drugs and the FRHs associated therewith.

In addition, [Table 5] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 4].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 4], the reactivity correlation value for each drug is divided by the classification factor 『/』 `` Exp_Drug (pval) '', and the correlation (Pvlaue) value of the gene expression corresponding to drug reactivity is arranged according to the order of drugs listed in [Table 4], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average value of the calculated values, and『 Rank 』means the number of female cancer drugs that the FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

Meanwhile, in FIG. 27, correlation values (P-vlaue) values of female biomarkers among major biomarkers among the biomarkers shown in Table 4 are graphically displayed, and in FIG. 28, genes expressed by major biomarkers P-vlaue values for female and female cancer drugs are shown graphically.

Reactive biomarkers for female and ovary drugs

No.	FRH	Drug	DrugType	Var (marker)
One	IRX5_3	1526_RDEA119 (rescreen) / 1242_ (5Z) -7-Oxozeaenol / 1372_Trametinib / 1498_AZD6244 / 1014_RDEA119 / 1378_Bleomycin (50uM) / 1005_Cisplatin / 1019_Bosutinib / 165_DMOG / 1015_CI-1040 / 1053 1006_Cytarabine / 1060_PD-0325901 / 1013_Nilotinib / 1018_ABT-888 / 1268_XAV 939 / 1003_Camptothecin / 262_VX-11e / 1037_BX-795 / 1024_CEP-701 / 1017_Olaparib / 1043_ / 308_XL-880 / 1264_SGC0946 / 1494_SN-38	erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / DNArep / DNArep / abl / other / erk_mapk / other / erk_mapk / abl / erk_mapk / g_integrity / DNArep / erk_mapk / abl / g_integrity / wnt / DNAmap / otherrep other / g_integrity / DNArep / jnk_p38 / mitosis / pi3k / igfr / rtk / chromatin / DNArep	1_13248174_T_C / 16_85071785_A_G / 9_34371054_A_C
2	IRX5_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 155_Ponatinib_2 / 1378_Bleomycin (50uM) _1 / 165_DMOG_3 / 1014_Refametinib_2 / 1242_ (5Z) -7-Oxozeaenol_3 / 159_HG6--1	erk_mapk / erk_mapk / erk_mapk / abl / DNArep / other / erk_mapk / other / erk_mapk	1_13248174_T_C
3	CMIP_1	1526_Refametinib_3 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1378_Bleomycin (50uM) _1	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / DNArep	16_85071785_A_G
4	PREX1_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 155_Ponatinib_2 / 1015_CI-1040_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk	9_34371054_A_C
5	HIST1H2BK_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk	6_132814681_A_G
6	SERPINE1_2	1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk	1_17240836_G_T / X_156025548_C_T
7	SGTB_1	1242_ (5Z) -7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2	other / erk_mapk / erk_mapk	9_74785802_T_C
8	XYLT2_1	1022_AZD7762_2 / 1378_Bleomycin (50uM) _1	g_integrity / DNArep	2_206056727_G_A
9	SOGA2_1	155_Ponatinib_2 / 1378_Bleomycin (50uM) _1	abl / DNArep	3_51980957_A_C
10	ZC3H12C_1	1378_Bleomycin (50uM) _1 / 1014_Refametinib_2	DNArep / erk_mapk	20_18452633_T_G
11	AFAP1L2_1	1526_Refametinib_3 / 1014_Refametinib_2	erk_mapk / erk_mapk	2_39717176_T_G
12	CHRNA5_1	134_Etoposide_1 / 295_NVP-BHG712_3	DNArep / rtk	3_196708735_G_GA
13	ASGR2_1	1024_Lestauritinib_2 / 1014_Refametinib_2	rtk / erk_mapk	10_38696926_C_T
14	RHBDL2_5	1114_Cetuximab_1	egfr	15_40896089_A_G / 15_40900360_T_C / 5_150068208_G_A / 10_132859105_C_T / 10_132860307_C_T
15	TMEM206_3	252_WZ3105_3	other	2_108378352_C_G / 14_106335417_A_C / 14_106360128_A_C
16	SUPT4H1_1	1022_AZD7762_2	g_integrity	11_114444466_A_G
17	LRTOMT_1	1022_AZD7762_2	g_integrity	19_10162649_G_A
18	EME2_1	1378_Bleomycin (50uM) _1	DNArep	7_108180467_G_T
19	TMEM158_1	1241_CHIR-99021_3	wnt	17_60211179_G_A
20	EFS_1	1242_ (5Z) -7-Oxozeaenol_3	other	19_30444797_C_A
21	CA5B_1	1378_Bleomycin (50uM) _1	DNArep	9_133696445_G_T
22	SDC1_1	1032_Afatinib_1	egfr	14_70246869_T_G
23	QSER1_1	226_GSK1070916_2	mitosis	13_79521022_A_T
24	GALNTL5_2	1012_Vorinostat_1	chromatin	15_34255437_A_T / 10_100352318_A_G
25	JAG1_5	1378_Bleomycin (50uM) _1	DNArep	3_122558313_G_T / 3_122558325_G_A / 3_122552357_T_TA / 3_122461164_C_G / 8_138636921_T_C
26	SOAT1_1	1022_AZD7762_2	g_integrity	7_108180467_G_T
27	BIRC2_1	231_FMK_3	erk_mapk	11_8101385_C_A
28	NAALADL2_1	1019_Bosutinib_1	abl	1_78893077_T_G
29	RGS2_1	1372_Trametinib_1	erk_mapk	18_12978734_C_G
30	PRR12_1	326_GSK690693_3	pi3k	6_38813973_C_T
31	AXL_2	1006_Cytarabine_1	DNArep	17_60211184_A_G / 5_224282_A_G
32	C6orf203_3	193_GW-2580_3	rtk	2_135390832_A_T / 17_48076840_A_G / 2_135230616_G_A
33	RNF208_2	255_CP724714_2	egfr	19_11832898_G_A / 4_7815971_GT_G
34	TNFRSF21_1	155_Ponatinib_2	abl	20_8802237_G_A
35	MAP6_1	29_AZ628_3	erk_mapk	7_6149477_GA_G
36	ABLIM1_1	1020_Lenalidomide_1 / 1017_Olaparib_2 / 1016_Temsirolimus_1 / 1170_CCT-018159_3 / 1004_Vinblastine_1 / 1033_Vismodegib_2	other / g_integrity / tor / other / cytoskeleton / other	4_70158293_T_TACAA
37	DIAPH1_5	1069_EHT-1864_3 / 222_BX-912_3	cytoskeleton / pi3k	7_73180651_C_T / 7_75212025_G_A / 7_74734035_C_T / 13_31758155_C_G / 7_72961358_G_A
38	FBXO10_5	222_BX-912_3 / 1008_Methotrexate_1	pi3k / DNArep	7_73180651_C_T / 7_75212025_G_A / 17_63918839_T_A / 7_72961358_G_A / 7_75403732_C_T
39	OLR1_1	1218_JQ1_3	chromatin	22_39017940_A_C
40	ADK_1	1001_AICA_Ribonucleotide_2	metabol	3_57269656_A_G
41	ETS1_5	1054_Palbociclib_2	cell_cyc	5_139680901_G_A / 5_150375777_G_T / 5_150393369_C_T / 9_41040359_C_T / 9_41938485_A_G
42	MDM2_4	1047_Nutlin-3a (-) _ 2	p53	8_89769704_A_C / 8_89786745_A_T / 8_89786749_T_TC / 8_89790263_A_G
43	NECAP1_1	1264_SGC0946_3	chromatin	11_92883335_A_C
44	PDZD8_1	194_Luminespib_2	other	2_120289468_AT_A
45	IFT46_1	1149_TW_37_3	apop	16_88608786_A_G
46	PLEKHA1_1	1032_Afatinib_1	egfr	16_89546571_ACC_AC
47	PTPN12_1	1006_Cytarabine_1	DNArep	7_63297679_T_C
48	CRH_1	277_Linifanib_2	rtk	2_208165676_C_T
49	UBE3B_1	301_PHA-793887_3	cell_cyc	1_3729650_T_C

Results of verification of biomarker responsiveness to female cancer drugs

No.	FRH	Var_Exp (pval)	Var_Drug (pval)	Exp_Drug (pval)	Ave_VarDrug (pval)	Rank
One	IRX5_3	3.24E-08	2.09E-07 / 3.36E-07 / 1.23E-06 / 3.42E-06 / 5.09E-06 / 1.67E-05 / 7.91E-05 / 9.90E-05 / 0.000147359 / 0.000178145 / 0.000262223 / 0.000293231 / 0.000294131 / 0.000331406 / 0.000346165 / 0.000948858 / 0.002531744 / 0.002544254 / 0.002864291 / 0.003760149 / 0.004676935 / 0.004858024 / 0.005464656 / 0.005509754 / 0.005666416 / 0.005771071 / 0.006260361 / 0.006581211 / 0.006918188 / 0.007120129 / 0.00796253 / 0.008656866 / 0.00957777	4.01E-09 / 2.44E-07 / 2.68E-10 / 4.32E-09 / 3.38E-07 / 2.17E-07 / 0.00038571 / 0.000925853 / 7.73E-07 / 0.000383325 / 0.166450357 / 4.98E-06 / 3.01E -07 / 0.002000118 / 0.000442004 / 5.99E-05 / 0.000267605 / 0.213034545 / 0.159498838 / 0.00525218 / 0.00102741 / 0.020521632 / 0.009232963 / 0.002752168 / 0.238349359 / 0.011791795 / 0.003679783 / 0.012982528 / 0.023648082 / 0.203584523 / 4.71E-0659 0.049 / 0.000738179	3.40E-03	35
2	IRX5_1	0.0000015986	0.0007150123535033939 / 0.0003369412837112573 / 0.00032406884840248645 / 0.03648245720851939 / 0.0011099296303187667 / 0.006369243766371333 / 0.0005814803877258011 / 2.2678944506803809e-07 / 0.03733962059148955	4.012472503651177e-09 / 2.6827328582081137e-10 / 4.315496540370196e-09 / 3.0113839929611485e-07 / 2.1676383298007365e-07 / 7.7324514359278e-07 / 3.3835336443110047e-07 / 2.4825768930569727e-07 / 4.858619088818164e-06	0.009251	9
3	CMIP_1	0.0000003363	0.00011611305549562358 / 0.0012463700637828415 / 0.0030883823789405102 / 0.0016967292437561562 / 0.009832494532448445 / 0.002480457099824004	1.6131899966597346e-09 / 6.919962939545994e-07 / 2.849790178430554e-07 / 2.9927531009991034e-06 / 1.2590036500767103e-06 / 2.2920451294642218e-05	0.003077	6
4	PREX1_1	0.0000031534	0.01213588709116456 / 0.0008861989870959789 / 0.003387644664627276 / 0.005046821727923961 / 0.003659189631662927 / 0.0025267752687901323	2.0425679890502906e-07 / 7.604358543728916e-08 / 1.5529027829933754e-06 / 8.474366468515741e-07 / 4.250842448563364e-06 / 0.00011933684147066083	0.004607	6
5	HIST1H2BK_1	0.0000012706	2.0249380516365964e-05 / 0.00145858467735631 / 0.00010968434987171273	1.2231056098636564e-07 / 5.613023240161599e-07 / 1.606715671371094e-06	0.00053	3
6	SERPINE1_2	0.0000002953	0.0003204627533032064 / 0.00024487596208109635 / 0.0018306053201144902	2.270680653678334e-11 / 2.0037545467736346e-09 / 1.775004443361545e-08	0.000799	3
7	SGTB_1	0.0000081282	0.03228197565235906 / 0.005309250379800075 / 0.014353588850730884	7.002520053010446e-07 / 5.734586888069177e-07 / 3.864698922480986e-05	0.017315	3
8	XYLT2_1	0.0000020721	0.001833777815813712 / 0.0011629202987970622	0.000260290223137108 / 2.671958043521113e-05	0.001498	2
9	SOGA2_1	0.0000002061	0.0023870087560347447 / 0.0009469777545024177	4.478657034092263e-06 / 1.4354947060633677e-06	0.001667	2
10	ZC3H12C_1	0.0000026717	0.00215309882934333 / 0.017221760779553733	4.767376309274578e-08 / 6.661607188017109e-09	0.009687	2
11	AFAP1L2_1	0.0000003807	0.004214389226040113 / 0.02332396009307528	5.907987029847344e-06 / 2.4672683509692957e-05	0.013769	2
12	CHRNA5_1	0.0000508839	0.006701963959523267 / 0.036047880162305805	1.9077675767419626e-05 / 0.0006068009313248781	0.021375	2
13	ASGR2_1	0.0000011382	0.02920277002386234 / 0.016061730805368494	3.539163247328943e-06 / 6.152399665513134e-06	0.022632	2
14	RHBDL2_5	0.0000019238	7.1199917547458675e-06	0.0003696677024808176	7.12E-06	One
15	TMEM206_3	0.0000000202	0.00010519155045059184	5.5593739090589024e-05	0.000105	One
16	SUPT4H1_1	0.0000006972	0.00033848343004505154	6.5359378871259295e-06	0.000338	One
17	LRTOMT_1	0.0000018098	0.000559295705994161	1.3683390744827602e-05	0.000559	One
18	EME2_1	0.0000170380	0.0006898652477534458	2.7131355664636215e-07	0.00069	One
19	TMEM158_1	0.0000030678	0.0009840625910486822	1.609343995544786e-08	0.000984	One
20	EFS_1	0.0002217830	0.001122491007265465	1.5915921114557537e-06	0.001122	One
21	CA5B_1	0.0000190483	0.0014397265221401374	8.834878342812196e-06	0.00144	One
22	SDC1_1	0.0000871778	0.0021240823853264194	0.000582674749763457	0.002124	One
23	QSER1_1	0.0036525535	0.0037407673565606763	0.006866210754238516	0.003741	One
24	GALNTL5_2	0.0000004536	0.0038242994255904676	3.729288833430345e-05	0.003824	One
25	JAG1_5	0.0001089795	0.00636641270645681	1.7383815237379935e-05	0.006366	One
26	SOAT1_1	0.0000020782	0.006999312347871926	2.80467015954591e-08	0.006999	One
27	BIRC2_1	0.0000155207	0.00816300663512002	0.00018077138183493182	0.008163	One
28	NAALADL2_1	0.0000138905	0.008284426750211397	4.480439955191913e-07	0.008284	One
29	RGS2_1	0.0000013280	0.009860060162808696	1.7551881489443127e-06	0.00986	One
30	PRR12_1	0.0000069754	0.009867491010242535	1.7189797251912035e-05	0.009867	One
31	AXL_2	0.0000000105	0.014240994766530759	1.5079800937023606e-08	0.014241	One
32	C6orf203_3	0.0000002251	0.01855978051000038	0.008786487798916599	0.01856	One
33	RNF208_2	0.0000001032	0.030124190690403667	0.009683329859510285	0.030124	One
34	TNFRSF21_1	0.0000749035	0.03240280858096773	0.00031416021519650137	0.032403	One
35	MAP6_1	0.0000692014	0.03353292578624218	0.00013432237477471032	0.033533	One
36	ABLIM1_1	0.0000289457	8.551014437375636e-05 / 6.439870760609185e-05 / 0.0004942044619000223 / 0.0013462707233938519 / 0.0001769380795123695 / 0.00046864428768627844	6.495937674540172e-07 / 8.724045720306562e-07 / 4.458187235187017e-06 / 0.00014338311206655668 / 8.320751548561286e-05 / 8.117521266562836e-06	0.000439	6
37	DIAPH1_5	0.0000000343	0.0021569775481875115 / 0.009558471051782936	4.2351723063700285e-07 / 0.0007897012263719693	0.005858	2
38	FBXO10_5	0.0000511525	0.012717520661373393 / 0.011413820480670385	3.075936790924862e-05 / 5.483582287867406e-06	0.012066	2
39	OLR1_1	0.0000390604	0.00013538297001416112	0.0010150743709979484	0.000135	One
40	ADK_1	0.0000356335	0.0003915086428142265	8.510841943631868e-06	0.000392	One
41	ETS1_5	0.0000663161	0.00041860694731410804	7.897108946289616e-05	0.000419	One
42	MDM2_4	0.0000777136	0.00045220053022167466	1.1021957487827008e-06	0.000452	One
43	NECAP1_1	0.0000018931	0.006023068066858825	1.373445231848715e-05	0.006023	One
44	PDZD8_1	0.0000027222	0.011837688751336296	0.0006499029052944853	0.011838	One
45	IFT46_1	0.0000115713	0.016014639151541662	0.004518015024378813	0.016015	One
46	PLEKHA1_1	0.0011885939	0.01781962701682115	1.7283045033609196e-07	0.01782	One
47	PTPN12_1	0.0001114367	0.02274194948059581	1.024090488420046e-06	0.022742	One
48	CRH_1	0.0000029508	0.03250849770203413	0.0017907240115171536	0.032508	One
49	UBE3B_1	0.0000100508	0.048482309371415636	1.9954445445928623e-06	0.048482	One

Table 6 lists the FRHs associated with brain tumor drugs and the markers defining the brain tumor drugs and FRHs associated with them.

In addition, [Table 7] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 6].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 6], the reactivity correlation value for each drug is divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug responsiveness according to the order of drugs listed in [Table 6], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average value of the calculated values, and『 Rank 』means the number of brain tumor drugs that significantly affect the corresponding FRH.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

On the other hand, in FIG. 29, the correlation values (P-vlaue) values of brain biomarkers among major biomarkers among the biomarkers listed in Table 6 are graphically displayed, and in FIG. 30, genes expressed by the major biomarkers And P-vlaue values for brain tumor drugs are graphed.

Reactive biomarkers for brain tumor drugs

No.	FRH	Drug	DrugType	Var (marker)
One	PTRF_9	9_MG-132 / 17_Cyclopamine / 34_Imatinib / 51_Dasatinib / 56_WH-4-023 / 94_TGX221 / 104_Bortezomib / 106_XMD8-85 / 147_NSC-87877 / 150_Bicalutamide / 151_QS11 / 156_AZD6482 / 159_HG-6-IP-1 178_BAY 61-3606 / 179_5-Fluorouracil / 184_BMS-754807 / 185_OSI-906 / 186_Bexarotene / 196_Phenformin / 199_Pazopanib / 200_LAQ824 / 211_TL-2-105 / 221_TAK-715 / 226_GSK1070916 / 228_KIN001 / 254 -II-72-1 / 263_FR-180204 / 265_Tubastatin A / 269_NSC-207895 / 272_AR-42 / 275_I-BET-762 / 276_CAY10603 / 281_CH5424802 / 288_KIN001-055 / 290_KIN001-260 / 291_KIN001-266 / 293_MP470-1- IN-1 / 300_CX-5461 / 304_SB52334 / 305_TPCA-1 / 310_YM201636 / 333_T0901317 / 344_THZ-2-49 / 345_KIN001-270 / 1007_Docetaxel / 1008_Methotrexate / 1011_ABT-263 / 1012_Vorinostat / 1016_Temsirolimus / 1016_Temsirolimus / 1016_Temsirolimus / 1016_Temsirolimus VIII / 1091_BMS-536924 / 1166_QL-VIII-58 / 1248_FK866 / 1261_r TRAIL / 1262_UNC1215 / 1264_SGC0946 / 1526_RDEA119 (rescreen) / 1527_GDC0941 (rescreen)	other / other / abl / abl / abl / pi3k / other / other / other / other / other / pi3k / erk_mapk / apop / cytoskeleton / other / DNArep / igfr / igfr / other / metabol / rtk / chromatin / erk_mapk / jnk_p38 / mitosis / pi3k / rtk / rtk / egfr / mitosis / erk_mapk / chromatin / p53 / chromatin / chromatin / chromatin / rtk / other / other / other / rtk / mitosis / other / rtk / other / other / other / cell_cyc / cell_cyc / cytoskeleton / DNArep / apop / chromatin / tor / other / rtk / other / jnk_p38 / igfr / tor / metabol / apop / other / chromatin / erk_mapk / pi3k	11_12162199_T_G / 13_113159942_A_G / 5_181155466_T_G / 11_65547388_T_G / 10_11921140_T_G / 17_55774876_T_G / 12_40313960_G_T / 16_1817242_T_C / 2_113934259_C_T
2	MBTD1_5	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 260 300_CX-5461_3 / 265_Tubastatin A_3 / 185_Linsitinib_2 / 253_XMD14-99_3	other / mitosis / rtk / chromatin / mitosis / DNArep / jnk_p38 / mitosis / chromatin / chromatin / apop / p53 / rtk / other / chromatin / igfr / rtk	17_55774876_T_G / 15_65451964_A_G / 2_113934259_C_T / 12_57062993_T_G / 11_65547388_T_G
3	C12orf29_4	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 275_I-BET-762_3 / 272_AR-42_2 / 310_YM201636_3 / 1012_Vorinostat_1 / 276_CAY10603_3 / 184_BMS-754807_2	mitosis / igfr / erk_mapk / other / chromatin / chromatin / other / chromatin / chromatin / igfr	12_40313960_G_T / 4_173528913_A_G / 15_65451964_A_G / 10_79312556_A_G
4	DDX20_1	294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 290_KIN001-260_3 / 276_CAY10603_3 / 1012_Vorinostat_1 / 270	mitosis / chromatin / other / other / mitosis / DNArep / other / chromatin / chromatin / cell_cyc	8_30756677_T_G
5	TACC1_4	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 221_TAK-715_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 253_XMD14-99_3 / 300_CX-5461_	chromatin / mitosis / rtk / jnk_p38 / DNArep / other / rtk / erk_mapk / rtk / other	11_12162199_T_G / 12_51745916_T_G / 16_15664675_G_T / 16_55415_T_G
6	SFPQ_1	1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 179_5-Fluorouracil_1 / 309_Y-39983_3 / 265_Tubastatin A_3 / 275_I-BET-762_3180_263	chromatin / other / mitosis / other / other / DNArep / cytoskeleton / chromatin / chromatin / erk_mapk	8_30756677_T_G
7	LRPPRC_2	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 184_BMS-754807_2 / 257_NPK76II	mitosis / other / rtk / igfr / chromatin / igfr / rtk / rtk / igfr / mitosis	12_40313960_G_T / 11_12162199_T_G
8	ILF3_5	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 / 263_FR-180204_3 / 288_WHI-P97_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / other / chromatin / apop / erk_mapk / other / mitosis / DNArep / rtk	5_181155466_T_G / 2_113934259_C_T / 11_12162199_T_G / 12_6818898_A_C / 15_65451964_A_G
9	ATXN7L3B_5	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 185_Linsitinib_2 / 226_GSK1070916_2 / 184_BMS-754807_2	other / mitosis / chromatin / rtk / mitosis / p53 / igfr / mitosis / igfr	2_113934259_C_T / 5_181155466_T_G / 15_65451964_A_G / 2_108507561_T_G / 12_57062993_T_G
10	CENPV_1	179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 185_Linsitinib_2	DNArep / chromatin / rtk / mitosis / other / other / rtk / apop / igfr	5_181155466_T_G
11	CAMKV_4	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3	mitosis / DNArep / other / other / rtk / chromatin / erk_mapk / rtk	13_113159942_A_G / 16_1817242_T_C / 3_128945112_G_A / 20_42084724_T_C
12	TPMT_3	253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 226_GSK1070916_2	rtk / mitosis / chromatin / rtk / DNArep / igfr / igfr / mitosis	9_37887606_C_T / 2_61492168_C_A / 11_12162199_T_G
13	WASF1_3	305_TPCA-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 269_NSC-207895_3 / 185_Linsitinib_2	other / chromatin / DNArep / mitosis / rtk / other / p53 / igfr	16_55415_T_G / 10_43200831_A_G / 2_108507561_T_G
14	DDX25_4	263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 255_CP724714_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1	erk_mapk / chromatin / mitosis / other / rtk / egfr / other / DNArep	2_61492168_C_A / 5_181155466_T_G / 11_43920052_A_C / 12_40313960_G_T
15	ACVR2B_5	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 265_Tubastatin A_3 / 1011_Navitoclax_2 / 263_FR-180204_3	DNArep / mitosis / rtk / chromatin / other / chromatin / apop / erk_mapk	16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G / 20_42084724_T_C / 11_34452090_T_G
16	TAP1_4	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 / 275_I-BET-762_3	mitosis / DNArep / chromatin / igfr / apop / rtk / other / chromatin	11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 20_42084724_T_C
17	SMPD1_1	1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 1011_Navitoclax_2 / 265_Tubastatin A_3	chromatin / DNArep / other / other / mitosis / jnk_p38 / apop / chromatin	16_87644643_G_A
18	PEA15_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 293_Amuvatinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 221_TAK-715_2 / 263_FR-180204_3	chromatin / mitosis / rtk / rtk / mitosis / other / jnk_p38 / erk_mapk	5_181155466_T_G / 10_50311228_T_G / 11_12162199_T_G / 22_18345007_A_C / 2_60761746_T_G
19	SLC25A43_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 / 179_5-Fluorouracil_1	mitosis / other / rtk / igfr / chromatin / erk_mapk / rtk / DNArep	1_54243266_A_G
20	MT2A_5	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 304_SB52334_3 / 185_Linsitinib_2	mitosis / DNArep / other / mitosis / chromatin / rtk / igfr	13_113159942_A_G / 22_42212334_A_C / 10_11921140_T_G / 15_75524142_T_C / X_100585180_G_T
21	RUNX1_2	196_Phenformin_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 94_TGX221_3 / 1166_QL-VIII-58_3 / 51_Dasatinib_1 / 1007_Docetaxel_1	metabol / cell_cyc / pi3k / pi3k / tor / abl / cytoskeleton	1_78629896_T_C / 8_7290003_A_C
22	LRRC8B_3	294_MPS-1-IN-1_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 263_FR-180204_3 / 276_CAY10603_3	mitosis / rtk / other / DNArep / other / erk_mapk / chromatin	12_40313960_G_T / 11_12162199_T_G / 17_55774876_T_G
23	PSMB9_4	294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2	mitosis / rtk / DNArep / chromatin / other / chromatin / igfr	11_12162199_T_G / 10_11921140_T_G / 16_55415_T_G / X_2856636_A_C
24	RRAS_5	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 269_NSC-207895_3 / 304_SB52334_3	mitosis / DNArep / other / apop / other / p53 / rtk	11_12162199_T_G / 2_113934259_C_T / 16_18379704_T_G / 13_113159942_A_G / 17_55774876_T_G
25	TMBIM1_5	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 185_Linsitinib_2	mitosis / DNArep / rtk / other / chromatin / other / igfr	17_51169925_C_T / 1_228244520_T_G / 1_213007133_T_G / 16_55415_T_G / 5_38950065_A_T
26	KLHL23_3	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 263_FR-180204_3 / 1011_Navitoclax_2 / 300_CX-5461_3 / 1012_Vorinostat_1	mitosis / DNArep / rtk / erk_mapk / apop / other / chromatin	13_113159942_A_G / 10_79312556_A_G / 13_113325635_A_G
27	EWSR1_1	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 288_WHI-P97_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 310_YM201636_3	mitosis / apop / other / other / DNArep / chromatin / other	20_42084724_T_C
28	ZNF124_3	1012_Vorinostat_1 / 1011_Navitoclax_2 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1	chromatin / apop / rtk / mitosis / other / other / DNArep	13_113159942_A_G / 2_170965958_A_C / 17_55774876_T_G
29	CAPG_2	1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 / 1527_Pictilisib_2 / 17_Cyclopamine_3 / 94_TGX221_3 / 1007_Docetaxel_1	other / cell_cyc / metabol / pi3k / other / pi3k / cytoskeleton	7_72942379_A_C / 15_56464990_A_C
30	TGOLN2_2	1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 300_CX-5461_3	chromatin / DNArep / mitosis / other / erk_mapk / rtk / other	19_7740447_T_G / 19_11402175_A_C
31	RBFOX1_1	294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3	mitosis / rtk / other / DNArep / rtk / other / rtk	1_213007133_T_G
32	RANBP2_2	305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 257_NPK76-II-72-1_3	other / rtk / mitosis / DNArep / other / p53 / mitosis	11_65547388_T_G / 15_55329691_T_C
33	CCT2_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 269_NSC-207895_3 / 272_AR-42_2 / 185_Linsitinib_2	mitosis / other / chromatin / erk_mapk / p53 / chromatin / igfr	12_40313960_G_T
34	CEP95_2	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 304_SB52334_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 1012_Vorinostat_1	DNArep / mitosis / mitosis / rtk / rtk / rtk / chromatin	17_55774876_T_G / 11_12162199_T_G
35	GINM1_3	294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 184_BMS-754807_2 / 1091_BMS-536924_3	mitosis / erk_mapk / rtk / igfr / chromatin / igfr / igfr	11_12162199_T_G / 4_154328181_A_C / 10_73803641_A_G
36	POLG2_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 304_SB52334_3 / 1091_BMS-536924_3 / 281_Alectinib_2 / 253_XMD14-99_3	chromatin / mitosis / jnk_p38 / rtk / igfr / rtk / rtk	22_22098988_G_T / 19_4911043_A_C
37	RAN_2	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2	mitosis / apop / chromatin / erk_mapk / other / DNArep / rtk	19_3281403_A_C / 10_11921140_T_G
38	MTF2_2	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 265_Tubastatin A_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 304_SB52334_3	other / mitosis / DNArep / chromatin / mitosis / p53 / rtk	5_181155466_T_G / 6_30705792_T_G
39	CMPK1_1	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 / 293_Amuvatinib_2 / 253_XMD14-99_3 / 304_SB52334_3	igfr / mitosis / igfr / chromatin / rtk / rtk / rtk	16_18379704_T_G
40	MDN1_1	1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 276_CAY10603_3 / 305_TPCA-1_3 / 269_NSC-207895_3	chromatin / apop / DNArep / mitosis / chromatin / other / p53	11_65547388_T_G
41	INPP1_2	265_Tubastatin A_3 / 276_CAY10603_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 310_YM201636_3	chromatin / chromatin / other / mitosis / DNArep / other	14_78966462_C_T / 16_55415_T_G
42	TOMM20_5	1012_Vorinostat_1 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3	chromatin / rtk / DNArep / mitosis / rtk / other	10_11921140_T_G / 20_42084724_T_C / 2_61492168_C_A / 17_55774876_T_G / 16_18379704_T_G
43	S100A6_3	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3	chromatin / mitosis / rtk / DNArep / apop / other	10_11921140_T_G / 7_159142364_T_G / 8_30756677_T_G
44	ZNF74_5	1012_Vorinostat_1 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 304_SB52334_3	chromatin / igfr / mitosis / igfr / other / rtk	5_181155466_T_G / 17_55774876_T_G / 1_234373536_T_G / 2_113934259_C_T / 2_61492168_C_A
45	ZNF195_3	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 226_GSK1070916_2	mitosis / other / rtk / erk_mapk / igfr / mitosis	12_40313960_G_T / 2_113934259_C_T / 12_51745916_T_G
46	DNMT3A_2	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 1091_BMS-536924_3	mitosis / other / chromatin / igfr / erk_mapk / igfr	2_113934259_C_T / 11_12162199_T_G
47	PXDC1_3	294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1	mitosis / rtk / other / igfr / DNArep / chromatin	13_113159942_A_G / 11_65547388_T_G / 7_159142364_T_G
48	HOXD8_1	253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 281_Alectinib_2	rtk / mitosis / rtk / erk_mapk / igfr / rtk	20_42084724_T_C
49	CREB3_5	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 304_SB52334_3	mitosis / chromatin / other / DNArep / rtk / rtk	5_181155466_T_G / 1_54243266_A_G / 11_12162199_T_G / 6_30705792_T_G / 12_6818898_A_C
50	HDAC2_5	1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 293_Amuvatinib_2 / 1012_Vorinostat_1 / 304_SB52334_3	apop / DNArep / other / rtk / chromatin / rtk	17_55774876_T_G / 11_65547388_T_G / 15_75524142_T_C / 14_55169342_TAAA_T / 15_55329691_T_C
51	TIMP1_5	179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 253_XMD14-99_3	DNArep / other / other / mitosis / apop / rtk	16_1817242_T_C / 3_128945112_G_A / 5_181155466_T_G / 16_30398066_C_A / 11_34452090_T_G
52	COQ10B_2	305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1	other / chromatin / mitosis / rtk / igfr / DNArep	13_113159942_A_G / 1_149852603_A_G
53	REEP5_3	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3	mitosis / other / DNArep / other / mitosis / rtk	5_181155466_T_G / 16_87644643_G_A / 2_113934259_C_T
54	FAM111A_5	304_SB52334_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 1091_BMS-536924_3	rtk / mitosis / igfr / chromatin / other / igfr	2_108507561_T_G / 13_113159942_A_G / 10_11921140_T_G / 16_1817242_T_C / 1_213007133_T_G
55	XPO5_2	1012_Vorinostat_1 / 269_NSC-207895_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 / 294_MPS-1-IN-1_3	chromatin / p53 / other / mitosis / chromatin / mitosis	15_75524142_T_C / 11_65547388_T_G
56	MICALL2_2	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 156_AZD6482_2	cell_cyc / metabol / pi3k / other / abl / pi3k	8_7290003_A_C / 7_72942379_A_C
57	ITGA3_1	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 288_WHI-P97_3	mitosis / chromatin / erk_mapk / other / DNArep / other	5_181155466_T_G
58	MATR3_5	304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 / 1011_Navitoclax_2	rtk / other / mitosis / DNArep / p53 / apop	17_55774876_T_G / 10_73803531_T_C / 11_65547388_T_G / 12_7433515_G_T / 16_18379704_T_G
59	SAT1_1	294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 185_Linsitinib_2	mitosis / rtk / chromatin / erk_mapk / other / igfr	12_40313960_G_T
60	TMED9_2	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3	other / mitosis / rtk / igfr / chromatin / erk_mapk	13_113159942_A_G / 11_12162199_T_G
61	KIF26A_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 1091_BMS-536924_3 / 263_FR-180204_3 / 185_Linsitinib_2	chromatin / mitosis / rtk / igfr / erk_mapk / igfr	10_11921140_T_G / 7_159142364_T_G
62	C19orf66_2	294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 310_YM201636_3	mitosis / rtk / other / rtk / rtk / other	16_87644643_G_A / X_2856636_A_C
63	GTF3C2_2	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 281_Alectinib_2 / 185_Linsitinib_2	mitosis / chromatin / rtk / erk_mapk / rtk / igfr	7_128839939_T_G / 7_159142364_T_G
64	ADAM9_5	294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 185_Linsitinib_2 / 1011_Navitoclax_2	mitosis / rtk / DNArep / rtk / igfr / apop	11_12162199_T_G / 12_51745916_T_G / 10_11921140_T_G / 8_122952205_T_G / 5_181155466_T_G
65	KDM1A_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 176_IPA-3_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3	mitosis / chromatin / other / cytoskeleton / DNArep / chromatin	1_26774532_T_C / 22_42212334_A_C / 5_181155466_T_G
66	SRSF1_1	1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2	chromatin / rtk / mitosis / mitosis / DNArep / rtk	16_87644643_G_A
67	WHAMM_1	1012_Vorinostat_1 / 305_TPCA-1_3 / 281_Alectinib_2 / 263_FR-180204_3 / 300_CX-5461_3 / 253_XMD14-99_3	chromatin / other / rtk / erk_mapk / other / rtk	2_113934259_C_T
68	LEPRE1_4	344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 106_XMD8-85_3 / 156_AZD6482_2	cell_cyc / pi3k / other / metabol / other / pi3k	3_191357867_G_A / 16_72119226_C_G / 3_191358113_C_T / 16_72150667_C_T
69	TRMT61B_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 185_Linsitinib_2	mitosis / other / rtk / chromatin / chromatin / igfr	12_124473081_C_T
70	KANK1_1	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3	mitosis / rtk / igfr / igfr / other / rtk	11_12162199_T_G
71	FAM126A_1	94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 / 51_Dasatinib_1 / 196_Phenformin_3	pi3k / cell_cyc / other / pi3k / abl / metabol	7_72942379_A_C
72	CASKIN1_1	1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3	chromatin / apop / DNArep / mitosis / rtk / igfr	10_11921140_T_G
73	PHIP_3	269_NSC-207895_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 / 300_CX-5461_3	p53 / mitosis / other / DNArep / mitosis / other	15_55329691_T_C / 15_55340661_G_T / 12_40313960_G_T
74	ISL1_1	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 1011_Navitoclax_2 / 281_Alectinib_2 / 304_SB52334_3	mitosis / chromatin / erk_mapk / apop / rtk / rtk	11_12162199_T_G
75	FAM114A1_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 275_I-BET-762_3 / 300_CX-5461_3	mitosis / DNArep / chromatin / other / chromatin / other	12_51745916_T_G
76	BHLHE40_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 1091_BMS-536924_3	chromatin / mitosis / erk_mapk / rtk / other / igfr	11_12162199_T_G / 6_30705792_T_G / 8_122952205_T_G / 14_93183653_A_C / 12_6941768_C_A
77	RNH1_2	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 281_Alectinib_2 / 253_XMD14-99_3	mitosis / DNArep / other / p53 / rtk / rtk	16_1817242_T_C / 13_113159942_A_G
78	SLC35F5_2	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3	mitosis / other / DNArep / rtk / chromatin / other	17_6118065_A_G / 13_113159942_A_G
79	TRAP1_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 263_FR-180204_3 / 1011_Navitoclax_2	chromatin / mitosis / other / rtk / erk_mapk / apop	9_69516199_A_C
80	SLC10A3_1	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3	DNArep / mitosis / chromatin / other / other / rtk	13_113159942_A_G
81	IL10RB_1	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 184_BMS-754807_2 / 263_FR-180204_3	igfr / mitosis / apop / other / igfr / erk_mapk	11_65547388_T_G
82	CCDC138_3	269_NSC-207895_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3	p53 / chromatin / other / DNArep / mitosis	15_75524142_T_C / 12_40313960_G_T / 8_30756677_T_G
83	LDLRAP1_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1	mitosis / other / igfr / rtk / DNArep	16_55415_T_G
84	SH3BGRL3_3	179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 253_XMD14-99_3	DNArep / other / apop / rtk / rtk	17_55774876_T_G / 16_87644643_G_A / 5_181155466_T_G
85	RARRES3_3	294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 / 263_FR-180204_3 / 1012_Vorinostat_1	mitosis / chromatin / DNArep / erk_mapk / chromatin	12_40313960_G_T / 1_213007133_T_G / 16_87644643_G_A
86	ANXA4_4	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 293_Amuvatinib_2	mitosis / chromatin / rtk / DNArep / rtk	19_11402175_A_C / 6_33799054_A_G / 8_30756677_T_G / 8_27431326_A_G
87	LYST_1	1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 310_YM201636_3	chromatin / other / mitosis / rtk / other	16_55415_T_G
88	MR1_4	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1	mitosis / apop / DNArep / other / chromatin	1_234373536_T_G / 15_84241166_A_C / 10_79312556_A_G / 19_7740447_T_G
89	SELRC1_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 253_XMD14-99_3	mitosis / other / chromatin / mitosis / rtk	12_40313960_G_T
90	LDHB_5	1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2	chromatin / other / mitosis / DNArep / apop	12_40313960_G_T / 11_12162199_T_G / 11_65547388_T_G / 5_181155466_T_G / 4_108762737_T_G
91	GBE1_2	344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 51_Dasatinib_1	cell_cyc / pi3k / other / metabol / abl	8_7290003_A_C / 7_72942379_A_C
92	PTRF_2	344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1	cell_cyc / pi3k / metabol / other / abl	8_7290003_A_C / 7_72942379_A_C
93	SQSTM1_3	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1	mitosis / other / igfr / rtk / DNArep	1_26774532_T_C / 11_12162199_T_G / 13_39724512_C_T
94	PA2G4_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1011_Navitoclax_2 / 310_YM201636_3	chromatin / mitosis / other / apop / other	12_40313960_G_T
95	GBP3_2	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 253_XMD14-99_3	mitosis / chromatin / igfr / other / rtk	15_75524142_T_C / 12_40313960_G_T
96	CHD7_2	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3	DNArep / mitosis / chromatin / other / chromatin	11_65547388_T_G / 12_40313960_G_T
97	ELF4_4	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 / 304_SB52334_3 / 263_FR-180204_3	mitosis / igfr / igfr / rtk / erk_mapk	13_113159942_A_G / 8_28850143_T_G / 2_108507561_T_G / 16_30953637_A_C
98	HEXB_2	294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1	mitosis / rtk / DNArep / other / chromatin	11_65547388_T_G / 11_12162199_T_G
99	TGOLN2_3	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2	cell_cyc / metabol / pi3k / other / pi3k	2_105307612_A_C / 7_72942379_A_C / 8_7290003_A_C
100	CBR3_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 276_CAY10603_3	chromatin / mitosis / DNArep / other / chromatin	8_30756677_T_G / 3_128945112_G_A / 12_6818898_A_C / 22_22098988_G_T / 2_60761746_T_G
101	C14orf93_1	1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 253_XMD14-99_3	chromatin / DNArep / igfr / erk_mapk / rtk	20_42084724_T_C
102	ACVR1B_5	1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 281_Alectinib_2	apop / mitosis / igfr / chromatin / rtk	5_181155466_T_G / 11_12162199_T_G / 10_79312556_A_G / 2_113934259_C_T / 12_6818898_A_C
103	WNK2_1	1011_Navitoclax_2 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3	apop / chromatin / DNArep / rtk / mitosis	10_11921140_T_G
104	GBE1_5	1012_Vorinostat_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3	chromatin / rtk / mitosis / DNArep / other	5_181155466_T_G / 16_58525116_G_T / 11_73355795_A_G / 10_11921140_T_G / 8_122952205_T_G
105	RAB27A_2	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2	cell_cyc / metabol / pi3k / other / pi3k	8_7290003_A_C / 15_56464990_A_C
106	FAP_3	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 221_TAK-715_2 / 345_KIN001-270_3	mitosis / DNArep / chromatin / jnk_p38 / cell_cyc	17_55774876_T_G / 1_183963850_T_G / 11_94082585_T_C
107	THBS1_1	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1	cell_cyc / metabol / pi3k / other / abl	8_7290003_A_C
108	RNF44_2	1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 305_TPCA-1_3	chromatin / igfr / DNArep / jnk_p38 / other	8_12430448_C_T / 10_11921140_T_G
109	C2orf44_4	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1	igfr / mitosis / chromatin / other / DNArep	7_108023984_G_A / 7_108024001_C_T / 11_65547388_T_G / 14_55169342_TAAA_T
110	ZSCAN2_1	304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 226_GSK1070916_2	rtk / other / mitosis / igfr / mitosis	2_61492168_C_A
111	PSMB8_3	294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 275_I-BET-762_3	mitosis / rtk / DNArep / igfr / chromatin	11_12162199_T_G / X_2856636_A_C / 10_11921140_T_G
112	CTGF_2	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1	mitosis / chromatin / rtk / igfr / DNArep	13_113159942_A_G / 2_188994726_T_G
113	DAP_1	1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 179_5-Fluorouracil_1	igfr / mitosis / chromatin / igfr / DNArep	12_51745916_T_G
114	PHOX2A_1	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 1091_BMS-536924_3	mitosis / chromatin / DNArep / igfr / igfr	12_51745916_T_G
115	MVP_2	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3	mitosis / DNArep / chromatin / other / rtk	12_40313960_G_T / 11_68785018_G_A
116	CCNJ_2	304_SB52334_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 305_TPCA-1_3 / 263_FR-180204_3	rtk / mitosis / rtk / other / erk_mapk	14_55169342_TAAA_T / 1_234373536_T_G
117	MAP4_5	294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 221_TAK-715_2	mitosis / rtk / other / chromatin / jnk_p38	16_81270082_T_G / 14_93183653_A_C / 1_54243266_A_G / 2_157299566_T_G / 16_58526137_A_C
118	ATP5B_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 263_FR-180204_3	chromatin / mitosis / igfr / other / erk_mapk	1_54243266_A_G / 6_31966660_T_G
119	TRAM2_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 1091_BMS-536924_3	mitosis / chromatin / rtk / erk_mapk / igfr	11_12162199_T_G / 13_113159942_A_G / 12_40313960_G_T
120	CCDC107_5	1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 263_FR-180204_3	chromatin / other / mitosis / other / erk_mapk	17_19414393_T_G / 11_1242476_T_G / 16_259458_T_G / 1_54243266_A_G / 1_171541102_T_G
121	SMARCAD1_5	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2	mitosis / other / rtk / igfr / igfr	12_40313960_G_T / 15_65451964_A_G / 11_65547388_T_G / 6_30705792_T_G / 17_55774876_T_G
122	HRH1_1	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3	mitosis / igfr / chromatin / DNArep / erk_mapk	9_108900415_C_A
123	KHDRBS1_2	1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3	chromatin / other / mitosis / igfr / mitosis	5_181155466_T_G / 12_6818898_A_C
124	E2F6_3	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 184_BMS-754807_2 / 305_TPCA-1_3	igfr / mitosis / erk_mapk / igfr / other	1_248122139_G_T / 1_248122185_A_G / 12_109800676_G_A
125	ELL2_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1091_BMS-536924_3 / 305_TPCA-1_3	chromatin / mitosis / erk_mapk / igfr / other	10_73803531_T_C / 5_181155466_T_G
126	BSN_2	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2	mitosis / igfr / other / DNArep / rtk	16_1817242_T_C / 13_113159942_A_G
127	ATG4A_5	1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2	chromatin / other / rtk / mitosis	2_61492168_C_A / 2_113934259_C_T / 9_108900415_C_A / 16_87644643_G_A / 9_35398502_T_G
128	CD44_4	1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2	chromatin / other / mitosis / igfr	12_40313960_G_T / 15_75524142_T_C / 12_51745916_T_G / 2_113934259_C_T
129	GSN_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1	chromatin / mitosis / apop / DNArep	10_11921140_T_G / 13_113159942_A_G / 5_181155466_T_G / 16_1817242_T_C / 15_75524142_T_C
130	CD99_5	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / apop / DNArep / rtk	16_1817242_T_C / 11_65547388_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_11921140_T_G
131	GNAI2_5	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2	mitosis / rtk / chromatin / apop	1_149852603_A_G / 1_150261398_T_G / 17_55774876_T_G / 1_154627925_A_C / 17_77213881_T_G
132	DDX60_5	294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3	mitosis / rtk / DNArep / other	11_12162199_T_G / 16_87644643_G_A / 2_108507561_T_G / 5_181155466_T_G / 1_26774532_T_C
133	MICALL2_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3	mitosis / chromatin / DNArep / erk_mapk	16_30953637_A_C / 11_12162199_T_G / 12_51745916_T_G
134	SOAT1_5	185_Linsitinib_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3	igfr / rtk / mitosis / other	5_181155466_T_G / 5_38950065_A_T / 12_40313960_G_T / 17_51169925_C_T / 2_61492168_C_A
135	PLEC_1	344_THZ-2-49_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 94_TGX221_3	cell_cyc / other / abl / pi3k	7_72942379_A_C
136	XRCC5_1	253_XMD14-99_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	rtk / erk_mapk / mitosis / DNArep	20_42084724_T_C
137	OSGEPL1_1	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3	erk_mapk / mitosis / chromatin / rtk	12_40313960_G_T
138	TMEM97_4	179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 300_CX-5461_3	DNArep / apop / chromatin / other	17_55774876_T_G / 20_33848655_A_C / 1_150261398_T_G / 12_6818898_A_C
139	GLIS3_4	185_Linsitinib_2 / 1091_BMS-536924_3 / 184_BMS-754807_2 / 1012_Vorinostat_1	igfr / igfr / igfr / chromatin	11_65547388_T_G / 2_66439901_A_C / 10_50311228_T_G / 8_41957277_G_C
140	ANXA1_5	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 185_Linsitinib_2	mitosis / rtk / chromatin / igfr	12_51745916_T_G / 5_181155466_T_G / 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C
141	FAM120A_5	179_5-Fluorouracil_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3	DNArep / rtk / mitosis / other	13_113159942_A_G / 3_128945112_G_A / 12_123499406_T_G / 20_42084724_T_C / 6_30705792_T_G
142	SAFB_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 305_TPCA-1_3	mitosis / chromatin / rtk / other	13_113159942_A_G / 14_55169342_TAAA_T / 10_11921140_T_G
143	ACTN4_4	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1	mitosis / rtk / igfr / DNArep	11_12162199_T_G / 12_51745916_T_G / 10_73803641_A_G / 1_213007133_T_G
144	FAM117B_5	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3	DNArep / mitosis / chromatin / other	5_181155466_T_G / 13_113159942_A_G / 1_15381304_A_C / 17_55774876_T_G / 10_11921140_T_G
145	TSSC1_1	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3	igfr / mitosis / igfr / erk_mapk	2_113934259_C_T
146	SERPINE2_1	94_TGX221_3 / 56_WH-4-023_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2	pi3k / abl / cell_cyc / other	7_72942379_A_C
147	IFNAR1_5	263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	erk_mapk / chromatin / mitosis / DNArep	15_84241166_A_C / 6_30642116_A_G / 19_4911043_A_C / 16_259458_T_G / 19_7740447_T_G
148	UEVLD_3	179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3	DNArep / chromatin / mitosis / rtk	10_11921140_T_G / 11_43920052_A_C / X_2856636_A_C
149	GUF1_5	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1	mitosis / igfr / DNArep / chromatin	11_65547388_T_G / 5_181155466_T_G / 1_213007133_T_G / 11_12162199_T_G / 17_55774876_T_G
150	GBP3_1	344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2	cell_cyc / pi3k / metabol / other	8_7290003_A_C
151	MED28_1	94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 196_Phenformin_3	pi3k / cell_cyc / pi3k / metabol	8_7290003_A_C
152	SLC2A10_1	344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2	cell_cyc / pi3k / metabol / other	8_7290003_A_C
153	CBR3_1	94_TGX221_3 / 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3	pi3k / other / cell_cyc / metabol	8_7290003_A_C
154	HIC2_1	344_THZ-2-49_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 94_TGX221_3	cell_cyc / other / metabol / pi3k	8_7290003_A_C
155	IGSF9_1	1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3	other / pi3k / metabol / cell_cyc	8_7290003_A_C
156	RCAN1_1	344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 94_TGX221_3	cell_cyc / metabol / other / pi3k	8_7290003_A_C
157	SAFB_1	196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2	metabol / cell_cyc / pi3k / other	8_7290003_A_C
158	HNRNPA0_2	1012_Vorinostat_1 / 293_Amuvatinib_2 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2	chromatin / rtk / DNArep / apop	17_55774876_T_G / 16_55415_T_G
159	ISL1_1	196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2	metabol / pi3k / cell_cyc / other	7_72942379_A_C
160	PPIC_1	1012_Vorinostat_1 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3	chromatin / igfr / mitosis / erk_mapk	2_66439901_A_C
161	CBX1_1	1011_Navitoclax_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	apop / other / DNArep / mitosis	20_42084724_T_C
162	ARID3B_1	1026_Tanespimycin_2 / 156_AZD6482_2 / 344_THZ-2-49_3 / 196_Phenformin_3	other / pi3k / cell_cyc / metabol	8_7290003_A_C
163	RNF157_1	1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 304_SB52334_3	apop / DNArep / rtk / rtk	10_11921140_T_G
164	EIF3L_2	1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	chromatin / igfr / DNArep / mitosis	17_51169925_C_T / 20_42084724_T_C
165	SLC25A43_2	94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3	pi3k / other / metabol / cell_cyc	8_7290003_A_C / 19_7627786_T_G
166	OLFML2A_1	196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 51_Dasatinib_1	metabol / cell_cyc / pi3k / abl	7_72942379_A_C
167	HNRNPA1L2_4	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 1012_Vorinostat_1	mitosis / apop / other / chromatin	2_113934259_C_T / 12_40313960_G_T / 5_181155466_T_G / 12_51745916_T_G
168	GPR125_1	1011_Navitoclax_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3	apop / rtk / mitosis / other	5_181155466_T_G
169	HFM1_5	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1	mitosis / rtk / apop / DNArep	6_73622013_G_C / 6_73635330_C_T / 10_79312556_A_G / 15_55340661_G_T / 11_12162199_T_G
170	FAM161A_3	179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 1009_Tretinoin_1	DNArep / other / apop / other	3_165019547_G_T / 11_65547388_T_G / 7_100104762_T_G
171	MYO1E_5	1012_Vorinostat_1 / 1091_BMS-536924_3 / 281_Alectinib_2 / 221_TAK-715_2	chromatin / igfr / rtk / jnk_p38	12_51745916_T_G / 2_113934259_C_T / 15_40767895_T_G / 8_41957277_G_C / 2_157299566_T_G
172	BHLHE40_2	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 156_AZD6482_2	cell_cyc / metabol / pi3k / pi3k	7_72942379_A_C / 8_7290003_A_C
173	IPO9_1	179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3	DNArep / chromatin / other / chromatin	12_51745916_T_G
174	MALT1_5	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3	erk_mapk / mitosis / chromatin / igfr	11_12162199_T_G / 19_4911043_A_C / 12_40313960_G_T / 8_122952205_T_G / 17_7797836_A_C
175	GDPD1_1	179_5-Fluorouracil_1 / 226_GSK1070916_2 / 300_CX-5461_3 / 294_MPS-1-IN-1_3	DNArep / mitosis / other / mitosis	9_69516199_A_C
176	CLIC1_5	294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3	mitosis / rtk / DNArep / igfr	16_1817242_T_C / 13_113159942_A_G / 6_30705800_T_G / 3_128945112_G_A / 5_181155466_T_G
177	GBP1_1	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 304_SB52334_3	mitosis / igfr / igfr / rtk	11_12162199_T_G
178	WDR1_4	294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2	mitosis / rtk / DNArep / jnk_p38	13_113159942_A_G / 16_1817242_T_C / 18_79527652_GAA_G / 10_11921140_T_G
179	NOLC1_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 305_TPCA-1_3	chromatin / mitosis / erk_mapk / other	1_234373536_T_G
180	SUCLG2_1	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3	mitosis / apop / rtk / other	2_113934259_C_T
181	TMEM50B_4	1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3	chromatin / erk_mapk / mitosis / mitosis	15_84241166_A_C / 6_30642116_A_G / 12_40313960_G_T / 10_27223356_T_C
182	TEP1_2	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3	mitosis / other / DNArep / other	13_113159942_A_G / 1_160801918_G_C
183	C1QTNF4_1	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 304_SB52334_3	DNArep / mitosis / other / rtk	2_108507561_T_G
184	SAMD9_2	294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1	mitosis / rtk / igfr / chromatin	11_12162199_T_G / 5_181155466_T_G
185	INTS2_1	226_GSK1070916_2 / 1012_Vorinostat_1 / 225_Genentech Cpd 10_3 / 305_TPCA-1_3	mitosis / chromatin / mitosis / other	20_42084724_T_C
186	FUBP1_1	253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1	rtk / DNArep / mitosis / chromatin	16_28169801_A_C
187	RPAP1_1	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 304_SB52334_3 / 1012_Vorinostat_1	mitosis / igfr / rtk / chromatin	2_96842345_G_C
188	HEXB_1	196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2	metabol / cell_cyc / pi3k / other	15_75876091_T_G
189	HNRNPU_1	305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3	other / chromatin / mitosis / p53	15_65451964_A_G
190	FUCA1_2	294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1	mitosis / chromatin / chromatin / DNArep	1_153341603_A_C / 11_12162199_T_G
191	NOTCH2_2	304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2	rtk / mitosis / other / igfr	11_65547388_T_G / 13_113159942_A_G
192	CCT4_1	1012_Vorinostat_1 / 276_CAY10603_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3	chromatin / chromatin / DNArep / p53	7_108023984_G_A
193	UTRN_3	1012_Vorinostat_1 / 263_FR-180204_3 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3	chromatin / erk_mapk / igfr / mitosis	7_108023984_G_A / 17_80962613_A_C / 19_4911043_A_C
194	CALU_1	94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 1026_Tanespimycin_2	pi3k / cell_cyc / pi3k / other	7_72942379_A_C
195	PLAUR_1	344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3	cell_cyc / pi3k / other / metabol	7_72942379_A_C
196	HIST1H3F_2	1012_Vorinostat_1 / 281_Alectinib_2 / 263_FR-180204_3 / 179_5-Fluorouracil_1	chromatin / rtk / erk_mapk / DNArep	9_35398502_T_G / 4_88731303_A_G
197	SHF_2	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1	mitosis / rtk / igfr / chromatin	2_108507561_T_G / 7_149432379_A_C
198	CERK_1	281_Alectinib_2 / 1011_Navitoclax_2 / 300_CX-5461_3 / 253_XMD14-99_3	rtk / apop / other / rtk	2_29320789_A_C
199	TADA1_1	344_THZ-2-49_3 / 156_AZD6482_2 / 159_HG6-64-1_3 / 94_TGX221_3	cell_cyc / pi3k / erk_mapk / pi3k	18_41955194_A_G
200	UBA7_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / other / DNArep / rtk	3_128945112_G_A
201	SETDB1_1	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3	DNArep / mitosis / chromatin / rtk	10_11921140_T_G
202	FEV_1	196_Phenformin_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 1057_Dactolisib_2	metabol / cell_cyc / other / pi3k	2_105307612_A_C
203	PLIN3_1	294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 / 185_Linsitinib_2	mitosis / rtk / rtk / igfr	11_12162199_T_G
204	CAPZB_1	253_XMD14-99_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	rtk / other / DNArep / mitosis	8_109289769_T_C
205	PRR14L_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3	mitosis / DNArep / other / other	11_65547388_T_G
206	SYT4_1	281_Alectinib_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3	rtk / mitosis / igfr / igfr	1_247949628_T_C
207	OSTM1_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 293_Amuvatinib_2	mitosis / other / igfr / rtk	11_12162199_T_G
208	ALKBH2_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 293_Amuvatinib_2	chromatin / mitosis / igfr / rtk	11_12162199_T_G / 19_3281403_A_C / 1_228244520_T_G / 16_30953637_A_C / 8_27431326_A_G
209	MSN_1	1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2	igfr / DNArep / chromatin / igfr	10_73803641_A_G
210	ESYT2_2	1012_Vorinostat_1 / 281_Alectinib_2 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1	chromatin / rtk / igfr / DNArep	10_73803641_A_G / 19_4911043_A_C
211	RSBN1_1	304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3	rtk / DNArep / other / other	13_113159942_A_G
212	ATL3_1	179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2	DNArep / other / mitosis / igfr	13_113159942_A_G
213	GLCCI1_2	294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 281_Alectinib_2	mitosis / rtk / igfr / rtk	16_1817242_T_C / 13_113159942_A_G
214	STX4_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1	mitosis / other / rtk / DNArep	13_113159942_A_G
215	ZFP36_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / other / DNArep / rtk	13_113159942_A_G
216	ITPR3_1	344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3	cell_cyc / other / pi3k / metabol	20_33072178_T_G
217	APEX1_1	1012_Vorinostat_1 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 275_I-BET-762_3	chromatin / other / rtk / chromatin	17_55774876_T_G
218	NAGK_1	1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3	chromatin / DNArep / apop / other	X_2856636_A_C
219	CTSO_2	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 300_CX-5461_3	DNArep / mitosis / erk_mapk / other	8_2963284_T_G / 19_6937330_T_G
220	GAL3ST3_5	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3	mitosis / other / rtk	16_55415_T_G / X_100585180_G_T / 10_79312556_A_G / 19_7740447_T_G / 1_228244520_T_G
221	UBA52_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3	mitosis / chromatin / other	13_113159942_A_G / 12_40313960_G_T / 11_65547388_T_G
222	MSRB3_4	304_SB52334_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	rtk / DNArep / mitosis	11_65547388_T_G / 2_108507561_T_G / 12_99655061_T_A / 13_113159942_A_G
223	MTPAP_3	179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3	DNArep / chromatin / mitosis	1_150261398_T_G / 11_65547388_T_G / 9_128964364_CT_C
224	UBE2O_4	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3	chromatin / mitosis / rtk	20_42084724_T_C / 10_11921140_T_G / 6_30705800_T_G / 1_155747580_A_G
225	RANBP17_1	304_SB52334_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2	rtk / mitosis / rtk	20_42084724_T_C
226	ZNF516_4	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3	DNArep / mitosis / other	17_55774876_T_G / 9_37887606_C_T / 3_184301903_T_G / 1_234373536_T_G
227	NKAIN1_3	294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3	mitosis / rtk / other	12_40313960_G_T / 13_113159942_A_G / 20_42084724_T_C
228	DHX9_3	269_NSC-207895_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3	p53 / other / mitosis	2_113934259_C_T / 15_65451964_A_G / 7_44964464_T_C
229	TET1_4	294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2	mitosis / rtk / igfr	15_40767895_T_G / 12_51745916_T_G / 2_188994726_T_G / 17_55774876_T_G
230	UHMK1_1	310_YM201636_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3	other / other / mitosis	8_30756677_T_G
231	KCNH8_2	94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2	pi3k / metabol / other	7_72942379_A_C / 20_62661184_C_T
232	PMEL_1	294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 263_FR-180204_3	mitosis / rtk / erk_mapk	20_42084724_T_C
233	TMEM177_2	1012_Vorinostat_1 / 253_XMD14-99_3 / 211_TL-2-105_3	chromatin / rtk / erk_mapk	12_40313960_G_T / 9_108900415_C_A
234	P4HB_3	305_TPCA-1_3 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3	other / apop / mitosis	6_30329265_T_C / 2_113934259_C_T / 6_39884042_G_A
235	GLB1_2	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3	other / mitosis / rtk	1_219979389_T_A / 1_54243266_A_G
236	NIPSNAP1_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	chromatin / mitosis / DNArep	2_86027990_C_A / 5_181155466_T_G / 2_60761746_T_G / 9_37887606_C_T / 12_51745916_T_G
237	STOX2_4	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3	mitosis / igfr / rtk	13_113159942_A_G / 11_65547388_T_G / 17_44212322_A_G / 16_1817242_T_C
238	HIC2_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	chromatin / mitosis / DNArep	11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 1_54243266_A_G / 14_67381608_G_T
239	DDX25_1	344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2	cell_cyc / pi3k / other	7_72942379_A_C
240	DNMT3A_1	344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3	cell_cyc / pi3k / metabol	7_72942379_A_C
241	EXT2_1	344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3	cell_cyc / pi3k / metabol	7_72942379_A_C
242	FAM129B_1	94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2	pi3k / cell_cyc / other	7_72942379_A_C
243	GINM1_1	344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3	cell_cyc / pi3k / metabol	7_72942379_A_C
244	HNRNPA1L2_1	94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2	pi3k / cell_cyc / other	7_72942379_A_C
245	MAN1B1_1	94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3	pi3k / metabol / cell_cyc	7_72942379_A_C
246	TACC1_1	344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2	cell_cyc / metabol / other	7_72942379_A_C
247	RIPK1_5	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / DNArep / rtk	11_12162199_T_G / 1_234373536_T_G / 2_190469793_G_C / 16_1817242_T_C / 11_65547388_T_G
248	ZBTB4_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1	mitosis / chromatin / DNArep	17_55774876_T_G / 10_11921140_T_G / 6_30705792_T_G
249	TLN1_5	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / DNArep / rtk	15_43578884_A_G / 13_113159942_A_G / 3_128945112_G_A / 11_12162199_T_G / 19_4911043_A_C
250	PCBP3_1	94_TGX221_3 / 51_Dasatinib_1 / 196_Phenformin_3	pi3k / abl / metabol	7_72942379_A_C
251	KIDINS220_2	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3	mitosis / igfr / other	2_113934259_C_T / 1_113549504_C_T
252	MYH9_4	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1	mitosis / chromatin / DNArep	9_69516199_A_C / 13_113159942_A_G / 1_15381304_A_C / 10_11921140_T_G
253	C2orf43_4	294_MPS-1-IN-1_3 / 263_FR-180204_3 / 185_Linsitinib_2	mitosis / erk_mapk / igfr	19_3281403_A_C / 20_42084724_T_C / 12_109800676_G_A / 7_108023984_G_A
254	CFLAR_5	1012_Vorinostat_1 / 304_SB52334_3 / 275_I-BET-762_3	chromatin / rtk / chromatin	17_55774876_T_G / 7_108023984_G_A / 5_181155466_T_G / 1_228244520_T_G / 5_38950065_A_T
255	RAB27A_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3	chromatin / mitosis / other	12_6818898_A_C / 16_20737706_A_C / 2_66439901_A_C / 5_181155466_T_G / 11_12162199_T_G
256	PLSCR4_2	294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3	mitosis / erk_mapk / rtk	16_55415_T_G / 17_51169925_C_T
257	RPUSD4_1	293_Amuvatinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3	rtk / chromatin / igfr	15_75524142_T_C
258	MPST_3	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1	DNArep / mitosis / chromatin	17_18353665_C_T / 1_150261398_T_G / 5_181155466_T_G
259	MSN_1	344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3	cell_cyc / other / pi3k	8_7290003_A_C
260	TGFB1I1_1	1026_Tanespimycin_2 / 94_TGX221_3 / 344_THZ-2-49_3	other / pi3k / cell_cyc	8_7290003_A_C
261	PRMT1_2	1012_Vorinostat_1 / 263_FR-180204_3 / 221_TAK-715_2	chromatin / erk_mapk / jnk_p38	1_26034759_T_G / 5_181155466_T_G
262	AGPAT3_3	179_5-Fluorouracil_1 / 275_I-BET-762_3 / 265_Tubastatin A_3	DNArep / chromatin / chromatin	11_65547388_T_G / 1_183963850_T_G / 13_113159942_A_G
263	NUPR1_2	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 272_AR-42_2	mitosis / other / chromatin	11_20049928_A_C / 12_40313960_G_T
264	RNPC3_2	265_Tubastatin A_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3	chromatin / DNArep / chromatin	20_5501817_T_G / 17_55774876_T_G
265	S100A6_2	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3	cell_cyc / metabol / pi3k	8_7290003_A_C / 7_72942379_A_C
266	GADD45B_2	294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1	mitosis / chromatin / chromatin	12_51745916_T_G / 11_12162199_T_G
267	IRF2_2_5	294_MPS-1-IN-1_3 / 269_NSC-207895_3 / 293_Amuvatinib_2	mitosis / p53 / rtk	1_149852603_A_G / 1_219979389_T_A
268	MVP_2_3	94_TGX221_3 / 344_THZ-2-49_3 / 196_Phenformin_3	pi3k / cell_cyc / metabol	11_68780792_C_A / 15_75876091_T_G
269	GTF2H5_2	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 184_BMS-754807_2	mitosis / igfr / igfr	3_165019547_G_T / 16_15664675_G_T
270	AGTPBP1_2	179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3	DNArep / other / mitosis	13_113159942_A_G / 11_65547388_T_G
271	TAGLN2_5	1091_BMS-536924_3 / 1011_Navitoclax_2 / 304_SB52334_3	igfr / apop / rtk	5_181155466_T_G / 12_7433515_G_T / 15_75524142_T_C / 20_2862756_T_G / 19_47441156_T_G
272	CCNT1_4	1012_Vorinostat_1 / 305_TPCA-1_3 / 269_NSC-207895_3	chromatin / other / p53	1_197912561_T_G / 5_115984518_A_T / 8_98032165_T_G / 15_65451964_A_G
273	KCNN4_1	196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3	metabol / cell_cyc / pi3k	8_7290003_A_C
274	PEA15_1	196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3	metabol / pi3k / cell_cyc	8_7290003_A_C
275	SAMD9_1	196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3	metabol / cell_cyc / pi3k	8_7290003_A_C
276	TRADD_3	179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3	DNArep / apop / mitosis	10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C
277	TAF5_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3	mitosis / chromatin / rtk	6_33799054_A_G / 19_3281403_A_C / 7_108023984_G_A
278	EFHD2_4	1091_BMS-536924_3 / 304_SB52334_3 / 281_Alectinib_2	igfr / rtk / rtk	12_51745916_T_G / 1_213007133_T_G / 1_451649_A_AG / 2_61492168_C_A
279	YIPF2_1	294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1011_Navitoclax_2	mitosis / erk_mapk / apop	2_113934259_C_T
280	ZBED4_2	1012_Vorinostat_1 / 305_TPCA-1_3 / 1011_Navitoclax_2	chromatin / other / apop	2_108507561_T_G / 11_65547388_T_G
281	RAB3C_1	1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3	other / metabol / cell_cyc	8_7290003_A_C
282	FOSL1_4	305_TPCA-1_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3	other / DNArep / chromatin	12_57062993_T_G / 12_51745916_T_G / 13_39724512_C_T / 1_213007133_T_G
283	INA_2	294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3	mitosis / rtk / erk_mapk	13_113159942_A_G / 16_1817242_T_C
284	FLVCR1_2	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3	mitosis / DNArep / rtk	10_11921140_T_G / 11_12162199_T_G
285	ATF7IP2_5	1264_SGC0946_3 / 293_Amuvatinib_2 / 151_QS11_3	chromatin / rtk / other	17_55774876_T_G / 10_73803531_T_C / 2_63887264_C_CA / 3_9789934_A_C / 1_149852603_A_G
286	S100A10_1	294_MPS-1-IN-1_3 / 281_Alectinib_2 / 304_SB52334_3	mitosis / rtk / rtk	10_11921140_T_G
287	TRIP6_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3	chromatin / mitosis / igfr	12_51745916_T_G
288	EIF3J_2	1012_Vorinostat_1 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3	chromatin / mitosis / p53	17_36429365_A_G / 1_237687398_C_T
289	CASP4_1	294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3	mitosis / rtk / chromatin	12_51745916_T_G
290	NSL1_2	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1	mitosis / apop / chromatin	11_12162199_T_G / 10_11921140_T_G
291	VASP_1	304_SB52334_3 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3	rtk / mitosis / rtk	11_12162199_T_G
292	COG2_3	253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	rtk / mitosis / DNArep	10_11921140_T_G / 16_87644643_G_A / 3_53891822_C_T
293	STMN4_3	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3	mitosis / igfr / erk_mapk	13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C
294	ARID2_1	304_SB52334_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1	rtk / mitosis / chromatin	11_12162199_T_G
295	TMEM145_2	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1	mitosis / igfr / DNArep	10_11921140_T_G / 11_34452090_T_G
296	RPS28_2	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3	mitosis / chromatin / other	15_43578884_A_G / 17_18282629_T_G
297	BHLHB9_5	300_CX-5461_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1	other / apop / DNArep	2_224001859_C_A / 2_224001670_G_A / 3_128908178_A_G / 13_113159942_A_G / 3_128908109_T_C
298	CCT3_2	94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2	pi3k / cell_cyc / pi3k	1_146969331_G_A / 1_16589114_C_T
299	ZBTB39_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1	mitosis / DNArep / chromatin	16_30953637_A_C
300	TGFBI_1	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3	DNArep / mitosis / rtk	11_12162199_T_G
301	DRAM1_2	294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1	mitosis / chromatin / DNArep	13_113159942_A_G / 12_40313960_G_T
302	TTC9B_4	294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2	mitosis / rtk / igfr	16_30953637_A_C / 16_1817242_T_C / 13_113159942_A_G / 3_128945112_G_A
303	CRABP1_2	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3	mitosis / igfr / erk_mapk	12_40313960_G_T / 9_69516199_A_C
304	PRNP_1	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 275_I-BET-762_3	mitosis / igfr / chromatin	12_51745916_T_G
305	RNF216_2	344_THZ-2-49_3 / 156_AZD6482_2 / 199_Pazopanib_2	cell_cyc / pi3k / rtk	2_230310834_T_C / 2_230401046_T_C
306	KCNH2_1	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3	mitosis / chromatin / erk_mapk	5_38950065_A_T
307	HDAC2_1	344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3	cell_cyc / metabol / pi3k	15_75876091_T_G
308	LDLRAD3_2	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1	mitosis / apop / DNArep	11_65547388_T_G / 1_112653581_C_T
309	DLG2_1	294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3	mitosis / chromatin / erk_mapk	8_30756677_T_G
310	ABHD2_2	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3	mitosis / other / rtk	20_31465452_G_A / 20_31476528_A_G
311	FICD_1	305_TPCA-1_3 / 310_YM201636_3 / 275_I-BET-762_3	other / other / chromatin	12_40313960_G_T
312	EML5_1	294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3	mitosis / igfr / rtk	19_3281403_A_C
313	ZNF280B_1	179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2	DNArep / other / apop	11_65547388_T_G
314	MAST1_1	294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3	mitosis / rtk / igfr	10_11921140_T_G
315	NBR2_4	1012_Vorinostat_1 / 221_TAK-715_2 / 226_GSK1070916_2	chromatin / jnk_p38 / mitosis	7_142944295_A_G / 7_142939444_T_G / 7_142939502_G_A / 19_3179506_A_C
316	ZSCAN16_1	94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2	pi3k / cell_cyc / other	16_72119226_C_G
317	CD109_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3	mitosis / other / rtk	10_11921140_T_G
318	ASCL1_1	94_TGX221_3 / 196_Phenformin_3 / 156_AZD6482_2	pi3k / metabol / pi3k	7_72942379_A_C
319	PRCC_2	344_THZ-2-49_3 / 94_TGX221_3 / 156_AZD6482_2	cell_cyc / pi3k / pi3k	2_105307612_A_C / 19_8943580_T_G
320	SYPL1_3	294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1	mitosis / igfr / DNArep	16_1817242_T_C / 3_128945112_G_A / 1_150261398_T_G
321	CACNA1B_3	294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1	mitosis / apop / DNArep	13_113159942_A_G / X_2856636_A_C / 16_1817242_T_C
322	FEV_3	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2	igfr / mitosis / igfr	16_1817242_T_C / 13_113159942_A_G / 2_71515762_T_C
323	VSTM2A_2	294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1	mitosis / rtk / DNArep	13_113159942_A_G / 16_1817242_T_C
324	DOC2A_1	179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3	DNArep / rtk / mitosis	22_42212334_A_C
325	MTR_1	253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2	rtk / mitosis / rtk	2_61492168_C_A
326	TMEM184B_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3	chromatin / mitosis / p53	13_113159942_A_G
327	ARID2_3	344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2	cell_cyc / metabol / other	16_72129067_G_T / 16_72164743_G_A / 16_72119226_C_G
328	TSEN54_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2	chromatin / mitosis / rtk	13_113325635_A_G / 11_12162199_T_G
329	LAMP2_1	1091_BMS-536924_3 / 1012_Vorinostat_1 / 263_FR-180204_3	igfr / chromatin / erk_mapk	6_33279455_T_G
330	GPX8_1	344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3	cell_cyc / other / pi3k	16_72119226_C_G
331	PRIM1_1	1011_Navitoclax_2 / 1012_Vorinostat_1 / 288_WHI-P97_3	apop / chromatin / other	2_218827668_A_C
332	MMD_3	1012_Vorinostat_1 / 281_Alectinib_2 / 294_MPS-1-IN-1_3	chromatin / rtk / mitosis	1_248441636_T_G / 8_122952205_T_G / 6_30705792_T_G
333	HSPD1_1	1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3	chromatin / erk_mapk / mitosis	17_55774876_T_G
334	TNFRSF12A_5	1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	igfr / DNArep / mitosis	2_60761746_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_50311228_T_G / 13_113159942_A_G
335	PLP2_4	1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2	igfr / mitosis / apop	8_30756677_T_G / 5_181155466_T_G / 12_104287190_A_G / 6_33296240_C_A
336	SNX3_1	294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2	mitosis / rtk / mitosis	1_248441636_T_G
337	SMC3_1	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	other / mitosis / DNArep	11_65547388_T_G
338	ARHGAP1_1	305_TPCA-1_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	other / DNArep / mitosis	13_113159942_A_G
339	LPP_1	94_TGX221_3 / 1026_Tanespimycin_2 / 1527_Pictilisib_2	pi3k / other / pi3k	18_909560_A_G
340	MGAT1_1	300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3	other / other / mitosis	13_113159942_A_G
341	TNFRSF1A_3	294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2	mitosis / rtk / rtk	13_39724512_C_T / 11_65547388_T_G / 17_55774876_T_G
342	C12orf10_1	1091_BMS-536924_3 / 1054_Palbociclib_2 / 1012_Vorinostat_1	igfr / cell_cyc / chromatin	10_73803641_A_G
343	KLF15_1	196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3	metabol / cell_cyc / pi3k	8_7259511_T_C
344	RSL1D1_1	1012_Vorinostat_1 / 333_T0901317_3 / 276_CAY10603_3	chromatin / other / chromatin	17_55774876_T_G
345	CDK2AP2_1	226_GSK1070916_2 / 275_I-BET-762_3 / 305_TPCA-1_3	mitosis / chromatin / other	13_113159942_A_G
346	ENOX1_1	294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3	mitosis / rtk / chromatin	13_113159942_A_G
347	KLHL36_1	1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 304_SB52334_3	apop / mitosis / rtk	13_113159942_A_G
348	C1R_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / DNArep / rtk	13_113159942_A_G
349	DLL3_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3	mitosis / DNArep / rtk	13_113159942_A_G
350	NPC1_1	1012_Vorinostat_1 / 185_Linsitinib_2 / 275_I-BET-762_3	chromatin / igfr / chromatin	6_106621398_T_C
351	BPTF_1	179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3	DNArep / chromatin / other	17_55774876_T_G
352	CCNB1IP1_1	1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3	chromatin / DNArep / other	17_55774876_T_G
353	NPC2_1	304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3	rtk / mitosis / other	13_113159942_A_G
354	ABAT_3	185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3	igfr / mitosis / igfr	16_24930679_T_G / 3_51381020_A_G / 19_18216930_A_C
355	CEP170_3	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G / 2_218266875_A_C / 11_65547388_T_G
356	NUCB1_3	253_XMD14-99_3 / 294_MPS-1-IN-1_3	rtk / mitosis	15_75524142_T_C / 1_26774532_T_C / 19_3281403_A_C
357	LAMP1_5	1012_Vorinostat_1 / 333_T0901317_3	chromatin / other	1_108718913_T_G / 5_181155466_T_G / 9_108900415_C_A / 2_154259039_T_G / 7_32543154_A_C
358	MAP4_2	94_TGX221_3 / 1026_Tanespimycin_2	pi3k / other	7_72942379_A_C / 8_7290003_A_C
359	MSH6_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3	mitosis / other	20_42084724_T_C
360	NECAP2_5	179_5-Fluorouracil_1 / 300_CX-5461_3	DNArep / other	1_45019269_T_G / 13_113159942_A_G / 16_1817242_T_C / 17_55774876_T_G / 9_37887606_C_T
361	RFX7_1	275_I-BET-762_3 / 305_TPCA-1_3	chromatin / other	15_65451964_A_G
362	LOXL1_1	94_TGX221_3 / 344_THZ-2-49_3	pi3k / cell_cyc	7_72942379_A_C
363	RAB11FIP5_1	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	7_72942379_A_C
364	SYNC_1	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	7_72942379_A_C
365	MYT1_2	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	17_41725799_T_G / 20_42084724_T_C
366	CNTNAP2_4	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	2_108507561_T_G / 13_113159942_A_G / X_2856636_A_C / 16_55415_T_G
367	SMARCA5_4	305_TPCA-1_3 / 294_MPS-1-IN-1_3	other / mitosis	15_65451964_A_G / 17_81086334_C_G / 11_65547388_T_G / 12_40313960_G_T
368	B3GNT9_4	179_5-Fluorouracil_1 / 1011_Navitoclax_2	DNArep / apop	15_66561152_T_G / 17_55774876_T_G / 11_65547388_T_G / 7_108023984_G_A
369	GAL_2	1012_Vorinostat_1 / 1091_BMS-536924_3	chromatin / igfr	2_66439901_A_C / 9_37887606_C_T
370	TRIM56_5	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	DNArep / mitosis	17_55774876_T_G / 13_113159942_A_G / 20_42084724_T_C / 16_1817242_T_C / 16_30953637_A_C
371	CRIM1_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1	mitosis / chromatin	12_40313960_G_T / 1_20724406_A_C / 17_44212322_A_G
372	PNMA3_5	294_MPS-1-IN-1_3 / 293_Amuvatinib_2	mitosis / rtk	2_113934259_C_T / 16_55415_T_G / 20_16044565_T_G / 22_17727059_T_G / 1_149852603_A_G
373	HIST3H2A_3	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	10_11921140_T_G / 16_18379704_T_G / 20_16044565_T_G
374	ATCAY_5	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 6_33279455_T_G / 9_5549463_A_C
375	SMARCA4_2	1012_Vorinostat_1 / 1011_Navitoclax_2	chromatin / apop	11_65547388_T_G / 5_181155466_T_G
376	LIN28B_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	5_181155466_T_G / 2_113934259_C_T
377	OLFML2A_5	263_FR-180204_3 / 294_MPS-1-IN-1_3	erk_mapk / mitosis	2_154854926_A_C / 17_7797836_A_C / 6_30705792_T_G / 11_65547388_T_G / 15_84241166_A_C
378	ACP1_5	294_MPS-1-IN-1_3 / 1011_Navitoclax_2	mitosis / apop	19_3281403_A_C / 2_113934259_C_T / 5_181155466_T_G / 2_86604885_C_A / 11_12162199_T_G
379	ACTL6B_3	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	16_1817242_T_C / 13_113159942_A_G / 11_43920052_A_C
380	PHF21B_4	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G / 16_30953637_A_C
381	BAZ1A_1	1012_Vorinostat_1 / 275_I-BET-762_3	chromatin / chromatin	15_65451964_A_G
382	TMEM30A_1	294_MPS-1-IN-1_3 / 1091_BMS-536924_3	mitosis / igfr	12_104287190_A_G
383	NOL11_2	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	8_7290003_A_C / 1_1918090_A_G
384	BEND4_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	5_181155466_T_G / 6_37022626_A_C / 2_237368621_T_G / 12_6818898_A_C / 12_51745916_T_G
385	ELOVL1_3	185_Linsitinib_2 / 179_5-Fluorouracil_1	igfr / DNArep	13_113159942_A_G / 16_1817242_T_C / 9_37887606_C_T
386	PFKM_4	1091_BMS-536924_3 / 294_MPS-1-IN-1_3	igfr / mitosis	13_20031246_A_C / 9_37887606_C_T / 20_16044565_T_G / 10_79312556_A_G
387	NMNAT1_2	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	15_82519765_A_C / 19_3281403_A_C
388	TIGD1_2	1012_Vorinostat_1 / 179_5-Fluorouracil_1	chromatin / DNArep	17_55774876_T_G / 1_150261398_T_G
389	ARL1_5	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	9_93293047_T_G / 13_113159942_A_G / 12_51745916_T_G / 6_25488355_C_T / 6_25510468_CAT_C
390	CPLX1_4	263_FR-180204_3 / 294_MPS-1-IN-1_3	erk_mapk / mitosis	16_1817242_T_C / 13_113159942_A_G / 16_30953637_A_C / 18_79527652_GAA_G
391	PAX6_5	1012_Vorinostat_1 / 263_FR-180204_3	chromatin / erk_mapk	1_234309145_T_G / 1_156286332_T_G / 1_54243266_A_G / 12_44376791_T_A / 10_50311228_T_G
392	ANXA2_5	1011_Navitoclax_2 / 294_MPS-1-IN-1_3	apop / mitosis	12_57178583_A_C / 2_86604885_C_A / 5_181155466_T_G / 6_33296240_C_A / 8_30756677_T_G
393	BHLHE41_1	305_TPCA-1_3 / 185_Linsitinib_2	other / igfr	2_113934259_C_T
394	DPYSL5_2	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G / 2_108507561_T_G
395	NCL_5	1012_Vorinostat_1 / 305_TPCA-1_3	chromatin / other	17_55774876_T_G / 19_3281403_A_C / 7_108023984_G_A / 11_65547388_T_G / 13_113159942_A_G
396	NEK6_3	294_MPS-1-IN-1_3 / 185_Linsitinib_2	mitosis / igfr	11_12162199_T_G / 13_39724512_C_T / 10_50311228_T_G
397	ADAM11_1	253_XMD14-99_3 / 294_MPS-1-IN-1_3	rtk / mitosis	9_128964364_CT_C
398	BMP1_1	94_TGX221_3 / 196_Phenformin_3	pi3k / metabol	7_72942379_A_C
399	CRABP1_1	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	7_72942379_A_C
400	CREB3_1	94_TGX221_3 / 344_THZ-2-49_3	pi3k / cell_cyc	7_72942379_A_C
401	CTSB_1	196_Phenformin_3 / 94_TGX221_3	metabol / pi3k	7_72942379_A_C
402	GLB1_1	196_Phenformin_3 / 94_TGX221_3	metabol / pi3k	7_72942379_A_C
403	LGALS3_1	196_Phenformin_3 / 94_TGX221_3	metabol / pi3k	7_72942379_A_C
404	SMPD1_1	94_TGX221_3 / 344_THZ-2-49_3	pi3k / cell_cyc	7_72942379_A_C
405	GTPBP4_1	263_FR-180204_3 / 1012_Vorinostat_1	erk_mapk / chromatin	12_40313960_G_T
406	ACTR3B_2	294_MPS-1-IN-1_3 / 310_YM201636_3	mitosis / other	13_113159942_A_G / 5_170034543_C_T
407	CSRP1_3	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	10_11921140_T_G / 2_27774175_G_T / 17_55774876_T_G
408	SEPHS1_1	1012_Vorinostat_1 / 305_TPCA-1_3	chromatin / other	2_113934259_C_T
409	ACTN2_1	253_XMD14-99_3 / 294_MPS-1-IN-1_3	rtk / mitosis	1_213007133_T_G
410	NMRK1_2	294_MPS-1-IN-1_3 / 1012_Vorinostat_1	mitosis / chromatin	12_7433515_G_T / 16_55415_T_G
411	TFAP2A_1	263_FR-180204_3 / 294_MPS-1-IN-1_3	erk_mapk / mitosis	3_165019547_G_T
412	CAV1_3	294_MPS-1-IN-1_3 / 1012_Vorinostat_1	mitosis / chromatin	17_81086334_C_G / 13_39724512_C_T / 12_51745916_T_G
413	PQLC3_2	1012_Vorinostat_1 / 179_5-Fluorouracil_1	chromatin / DNArep	10_11921140_T_G / 16_18379704_T_G
414	RPL9_4	179_5-Fluorouracil_1 / 305_TPCA-1_3	DNArep / other	11_12162199_T_G / 3_165019547_G_T / 11_65547388_T_G / 16_72788732_T_G
415	H2AFY2_3	185_Linsitinib_2 / 294_MPS-1-IN-1_3	igfr / mitosis	10_11921140_T_G / 1_213007133_T_G / 11_12162199_T_G
416	MCM10_1	1011_Navitoclax_2 / 1012_Vorinostat_1	apop / chromatin	2_170965958_A_C
417	G6PD_1	179_5-Fluorouracil_1 / 300_CX-5461_3	DNArep / other	16_87644643_G_A
418	TADA1_1	179_5-Fluorouracil_1 / 1012_Vorinostat_1	DNArep / chromatin	10_11921140_T_G
419	KCNC1_5	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	16_30953637_A_C / 9_5549463_A_C / 17_76472531_A_C / 11_43920052_A_C / 16_1817242_T_C
420	JPH4_1	294_MPS-1-IN-1_3 / 281_Alectinib_2	mitosis / rtk	12_40313960_G_T
421	ZNF121_3	263_FR-180204_3 / 179_5-Fluorouracil_1	erk_mapk / DNArep	13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G
422	TMEM206_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	9_69516199_A_C
423	HS3ST4_1	179_5-Fluorouracil_1 / 300_CX-5461_3	DNArep / other	3_128945112_G_A
424	MRPL48_1	1264_SGC0946_3 / 1012_Vorinostat_1	chromatin / chromatin	5_181155466_T_G
425	PPAT_5	294_MPS-1-IN-1_3 / 1012_Vorinostat_1	mitosis / chromatin	8_27431326_A_G / 1_228244520_T_G / 6_56557393_C_T / 1_46261223_G_A / 1_234373536_T_G
426	CELF3_3	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	3_128908109_T_C / 16_1817242_T_C / 3_128945112_G_A
427	ABCC8_1	294_MPS-1-IN-1_3 / 281_Alectinib_2	mitosis / rtk	3_128945112_G_A
428	KIF1C_4	304_SB52334_3 / 294_MPS-1-IN-1_3	rtk / mitosis	13_113159942_A_G / 19_43359207_C_A / 16_1817242_T_C / 9_93293047_T_G
429	MOSPD2_1	263_FR-180204_3 / 1012_Vorinostat_1	erk_mapk / chromatin	11_12162199_T_G
430	ANKRD46_1	304_SB52334_3 / 294_MPS-1-IN-1_3	rtk / mitosis	10_11921140_T_G
431	RSL24D1_1	1012_Vorinostat_1 / 1091_BMS-536924_3	chromatin / igfr	9_69516199_A_C
432	HNRNPC_1	94_TGX221_3 / 196_Phenformin_3	pi3k / metabol	8_7290003_A_C
433	LYST_1	196_Phenformin_3 / 94_TGX221_3	metabol / pi3k	8_7290003_A_C
434	MRPS31_2	304_SB52334_3 / 1012_Vorinostat_1	rtk / chromatin	1_112520503_A_G / 11_65547388_T_G
435	ANXA11_1	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	DNArep / mitosis	16_1817242_T_C
436	GABRB3_2	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	13_113159942_A_G / 16_1817242_T_C
437	ITGB5_4	179_5-Fluorouracil_1 / 1012_Vorinostat_1	DNArep / chromatin	2_154854926_A_C / 1_234373536_T_G / 11_65547388_T_G / 17_55774876_T_G
438	TAGLN_5	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	2_157299566_T_G / 22_18345007_A_C / 1_54243266_A_G / 1_156286332_T_G / X_49565582_A_C
439	KLF6_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3	mitosis / other	12_95474188_T_G
440	GLIS3_1	344_THZ-2-49_3 / 196_Phenformin_3	cell_cyc / metabol	8_7290003_A_C
441	GRPEL2_3	1012_Vorinostat_1 / 179_5-Fluorouracil_1	chromatin / DNArep	9_108900415_C_A / 5_133233474_T_G / 10_11921140_T_G
442	SORCS1_2	294_MPS-1-IN-1_3 / 281_Alectinib_2	mitosis / rtk	16_259458_T_G / 13_113159942_A_G
443	TAF3_1	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	15_75876091_T_G
444	ZNF638_4	304_SB52334_3 / 269_NSC-207895_3	rtk / p53	10_73803531_T_C / 13_39724512_C_T / 22_17727059_T_G / 5_427675_T_C
445	RPAIN_2	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	9_69516199_A_C / 11_18089364_C_A
446	PRMT6_2	275_I-BET-762_3 / 305_TPCA-1_3	chromatin / other	7_35240878_C_T / 3_53872486_G_A
447	CERCAM_1	1012_Vorinostat_1 / 305_TPCA-1_3	chromatin / other	6_30705792_T_G
448	TWSG1_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	12_51745916_T_G
449	NAP1L1_1	305_TPCA-1_3 / 272_AR-42_2	other / chromatin	7_2269556_T_A
450	NQO2_1	179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3	DNArep / mitosis	10_79312556_A_G
451	EXOSC5_1	1012_Vorinostat_1 / 179_5-Fluorouracil_1	chromatin / DNArep	7_108023984_G_A
452	LTBP2_1	196_Phenformin_3 / 344_THZ-2-49_3	metabol / cell_cyc	11_68780792_C_A
453	KIAA1549_3	304_SB52334_3 / 294_MPS-1-IN-1_3	rtk / mitosis	17_75834935_G_A / 15_40855887_C_T / 15_40855965_C_T
454	LRP10_2	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	11_65547388_T_G / 17_55774876_T_G
455	CIB1_4	185_Linsitinib_2 / 1012_Vorinostat_1	igfr / chromatin	13_113159942_A_G / 1_150261398_T_G / 16_1817242_T_C / 1_149852603_A_G
456	RPL19_1	1012_Vorinostat_1 / 226_GSK1070916_2	chromatin / mitosis	2_61492168_C_A
457	CBX2_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	10_73803641_A_G / 17_80352778_T_G
458	CLVS2_2	1091_BMS-536924_3 / 294_MPS-1-IN-1_3	igfr / mitosis	2_108507561_T_G / 11_65547388_T_G
459	GLIPR1_2	1012_Vorinostat_1 / 179_5-Fluorouracil_1	chromatin / DNArep	19_4911043_A_C / 10_11921140_T_G
460	TAPBP_3	294_MPS-1-IN-1_3 / 275_I-BET-762_3	mitosis / chromatin	11_12162199_T_G / 16_30953637_A_C / 12_40313960_G_T
461	GNA12_3	179_5-Fluorouracil_1 / 300_CX-5461_3	DNArep / other	13_113325626_T_C / 7_129389033_T_G / 12_51745916_T_G
462	MBNL1_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	9_69516199_A_C
463	ISYNA1_2	344_THZ-2-49_3 / 156_AZD6482_2	cell_cyc / pi3k	15_43716974_A_C / 3_197683305_A_C
464	PRLHR_2	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	10_26746549_C_T / 6_56067480_C_T
465	IQGAP1_5	1091_BMS-536924_3 / 1012_Vorinostat_1	igfr / chromatin	8_122952205_T_G / 3_128945112_G_A / 13_113325635_A_G / 19_9566733_T_G / 5_181155466_T_G
466	SDC4_2	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	12_40313960_G_T / 13_113159942_A_G
467	NAA25_1	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	7_108023984_G_A
468	PLEKHA4_1	294_MPS-1-IN-1_3 / 226_GSK1070916_2	mitosis / mitosis	7_2269556_T_A
469	TUBA4A_2	1012_Vorinostat_1 / 1091_BMS-536924_3	chromatin / igfr	7_159142364_T_G / 11_65547388_T_G
470	SLC35D1_1	293_Amuvatinib_2 / 1012_Vorinostat_1	rtk / chromatin	16_18379704_T_G
471	SH3GLB1_1	1012_Vorinostat_1 / 1011_Navitoclax_2	chromatin / apop	20_42084724_T_C
472	RPL37_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3	mitosis / other	11_12162199_T_G
473	KDELR3_3	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A
474	DDX60L_1	1011_Navitoclax_2 / 179_5-Fluorouracil_1	apop / DNArep	11_12162199_T_G
475	GNPDA2_1	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	3_191358113_C_T
476	DPY30_1	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	14_23276467_A_G
477	MURC_2	1011_Navitoclax_2 / 294_MPS-1-IN-1_3	apop / mitosis	17_73203001_T_G / 8_61583890_T_A
478	CCDC80_2	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	16_72119226_C_G / 16_72129067_G_T
479	C12orf23_1	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	16_72119226_C_G
480	LOX_1	344_THZ-2-49_3 / 94_TGX221_3	cell_cyc / pi3k	16_72119226_C_G
481	CEP68_3	185_Linsitinib_2 / 304_SB52334_3	igfr / rtk	13_113159942_A_G / 8_12430448_C_T / 17_55774876_T_G
482	BEND3_1	196_Phenformin_3 / 344_THZ-2-49_3	metabol / cell_cyc	15_75876091_T_G
483	RPRD2_3	156_AZD6482_2 / 344_THZ-2-49_3	pi3k / cell_cyc	1_146975626_G_A / 1_146969331_G_A / 1_148117837_C_T
484	ELAVL4_3	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G / 7_108023984_G_A / 7_108024001_C_T
485	TRIM21_1	294_MPS-1-IN-1_3 / 253_XMD14-99_3	mitosis / rtk	1_237687398_C_T
486	PRPF40B_1	294_MPS-1-IN-1_3 / 1091_BMS-536924_3	mitosis / igfr	17_64146068_T_G
487	DCLRE1A_1	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	1_219979389_T_A
488	DUSP12_1	1012_Vorinostat_1 / 304_SB52334_3	chromatin / rtk	15_75524142_T_C
489	TFPI_2	294_MPS-1-IN-1_3 / 1011_Navitoclax_2	mitosis / apop	1_213007133_T_G / 16_1817242_T_C
490	MYO1C_2	1011_Navitoclax_2 / 304_SB52334_3	apop / rtk	11_65547388_T_G / 13_113159942_A_G
491	SYDE1_1	94_TGX221_3 / 344_THZ-2-49_3	pi3k / cell_cyc	18_41955194_A_G
492	RANBP1_1	1012_Vorinostat_1 / 288_WHI-P97_3	chromatin / other	6_30705792_T_G
493	PRAME_3	179_5-Fluorouracil_1 / 1009_Tretinoin_1	DNArep / other	16_67909562_C_A / 22_42212334_A_C / 19_57720377_A_G
494	PNN_1	305_TPCA-1_3 / 179_5-Fluorouracil_1	other / DNArep	13_39724512_C_T
495	PHF11_3	300_CX-5461_3 / 305_TPCA-1_3	other / other	11_12162199_T_G / X_2856636_A_C / X_119150617_A_C
496	WDR35_1	185_Linsitinib_2 / 294_MPS-1-IN-1_3	igfr / mitosis	12_109800676_G_A
497	KCNN4_5	1091_BMS-536924_3 / 1012_Vorinostat_1	igfr / chromatin	5_181155466_T_G / 20_45938939_T_G / 10_11921140_T_G / 1_15381304_A_C / 10_50311228_T_G
498	SERPINB6_1	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	2_227062473_GT_G
499	ACOT9_5	294_MPS-1-IN-1_3 / 1091_BMS-536924_3	mitosis / igfr	10_11921140_T_G / 11_12162199_T_G / 3_128945112_G_A / 13_113159942_A_G / 6_29631350_A_G
500	LAMP1_2	344_THZ-2-49_3 / 196_Phenformin_3	cell_cyc / metabol	1_99728613_A_C / 7_72942379_A_C
501	C19orf10_2	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	16_72129067_G_T / 16_72119226_C_G
502	EHD2_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	6_10410133_T_G
503	DPH5_1	1012_Vorinostat_1 / 1054_Palbociclib_2	chromatin / cell_cyc	8_12430448_C_T
504	TMEM169_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	1_112520503_A_G
505	SMARCB1_1	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	3_197683305_A_C
506	PLEKHF2_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	7_108023984_G_A
507	HSF2_5	179_5-Fluorouracil_1 / 1011_Navitoclax_2	DNArep / apop	11_65547388_T_G / 2_178663651_C_T / 1_234373536_T_G / 16_67878678_T_G / 2_178689190_G_A
508	ASPH_1	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	2_105307612_A_C
509	SERINC3_1	344_THZ-2-49_3 / 196_Phenformin_3	cell_cyc / metabol	2_105307612_A_C
510	THOC5_1	196_Phenformin_3 / 344_THZ-2-49_3	metabol / cell_cyc	3_197683305_A_C
511	SLC6A15_1	253_XMD14-99_3 / 294_MPS-1-IN-1_3	rtk / mitosis	17_55774876_T_G
512	TBC1D2_1	1012_Vorinostat_1 / 305_TPCA-1_3	chromatin / other	1_185150475_G_A
513	HSPG2_1	344_THZ-2-49_3 / 51_Dasatinib_1	cell_cyc / abl	1_37703244_A_C
514	CACNA2D2_1	294_MPS-1-IN-1_3 / 185_Linsitinib_2	mitosis / igfr	17_76472531_A_C
515	SLC5A6_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	7_108023984_G_A / 14_22844242_T_G
516	DAZAP1_2	1012_Vorinostat_1 / 294_MPS-1-IN-1_3	chromatin / mitosis	6_73622013_G_C / 6_73635330_C_T
517	NFIX_2	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	10_101004037_A_C / 12_109800676_G_A
518	ELAVL3_3	196_Phenformin_3 / 344_THZ-2-49_3	metabol / cell_cyc	2_15474280_T_C / 2_15475786_A_G / 2_15467718_T_C
519	COPB2_1	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	19_16503339_T_G
520	ZNF219_1	1026_Tanespimycin_2 / 156_AZD6482_2	other / pi3k	15_43716974_A_C
521	RNF165_2	294_MPS-1-IN-1_3 / 281_Alectinib_2	mitosis / rtk	10_11921140_T_G / 16_1817242_T_C
522	P4HA1_1	1011_Navitoclax_2 / 281_Alectinib_2	apop / rtk	16_58525116_G_T
523	CIB2_3	344_THZ-2-49_3 / 1026_Tanespimycin_2	cell_cyc / other	11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G
524	LMAN2_1	305_TPCA-1_3 / 294_MPS-1-IN-1_3	other / mitosis	11_65547388_T_G
525	POFUT1_1	1026_Tanespimycin_2 / 104_Bortezomib_1	other / other	4_118640836_A_T
526	ITGB1_1	94_TGX221_3 / 344_THZ-2-49_3	pi3k / cell_cyc	20_46216899_A_C
527	GFPT2_2	156_AZD6482_2 / 94_TGX221_3	pi3k / pi3k	7_72942379_A_C / 1_12938859_G_A
528	SNTB2_2	1026_Tanespimycin_2 / 94_TGX221_3	other / pi3k	5_36985201_A_G / 5_37000972_A_G
529	FAM126A_1	304_SB52334_3 / 294_MPS-1-IN-1_3	rtk / mitosis	1_451649_A_AG
530	FAM214B_1	1012_Vorinostat_1 / 345_KIN001-270_3	chromatin / cell_cyc	20_24959779_A_C
531	E2F5_1	1012_Vorinostat_1 / 221_TAK-715_2	chromatin / jnk_p38	19_16896123_T_G
532	CRMP1_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G
533	DTX3L_1	304_SB52334_3 / 294_MPS-1-IN-1_3	rtk / mitosis	13_113159942_A_G
534	ELAVL3_1	304_SB52334_3 / 294_MPS-1-IN-1_3	rtk / mitosis	13_113159942_A_G
535	GATA2_1	294_MPS-1-IN-1_3 / 185_Linsitinib_2	mitosis / igfr	13_113159942_A_G
536	GNG4_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G
537	GPX8_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G
538	LATS2_1	294_MPS-1-IN-1_3 / 304_SB52334_3	mitosis / rtk	13_113159942_A_G
539	TMEM87B_1	1011_Navitoclax_2 / 304_SB52334_3	apop / rtk	1_237687398_C_T
540	NR2C1_1	305_TPCA-1_3 / 1091_BMS-536924_3	other / igfr	9_88647472_G_A
541	CHMP4B_1	333_T0901317_3 / 1012_Vorinostat_1	other / chromatin	16_66912991_CGT_C
542	HPDL_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1	mitosis / DNArep	6_41770599_T_G
543	HNRPDL_1	1012_Vorinostat_1 / 1011_Navitoclax_2	chromatin / apop	17_55774876_T_G
544	MICB_1	275_I-BET-762_3 / 304_SB52334_3	chromatin / rtk	17_81086334_C_G
545	C17orf53_5	1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk	3_128481377_A_C / 7_142940415_T_G / 17_74777339_T_G / X_24788994_C_T / 19_39885857_T_G
546	WDR3_1	276_CAY10603_3 / 1012_Vorinostat_1	chromatin / chromatin	5_88722571_GA_G
547	FKBP15_1	196_Phenformin_3 / 344_THZ-2-49_3	metabol / cell_cyc	2_200493236_A_C
548	SLC22A23_1	94_TGX221_3	pi3k	7_72942379_A_C
549	ST6GALNAC3_1	344_THZ-2-49_3	cell_cyc	7_72942379_A_C
550	RCAN1_3	1012_Vorinostat_1	chromatin	11_65547388_T_G / 2_66439901_A_C / 7_159142364_T_G
551	CCDC107_2	94_TGX221_3	pi3k	7_72942379_A_C / 20_62661184_C_T
552	PAX6_2	94_TGX221_3	pi3k	7_72942379_A_C / 7_5227302_G_C
553	IGSF9_5	1012_Vorinostat_1	chromatin	16_87644643_G_A / 5_181155466_T_G / 13_113325635_A_G / 12_6818898_A_C / 11_12162199_T_G
554	TFAP4_2	1012_Vorinostat_1	chromatin	5_181155466_T_G / 11_65547388_T_G
555	B2M_5	294_MPS-1-IN-1_3	mitosis	11_12162199_T_G / 12_6818898_A_C / 20_42084724_T_C / 1_108718913_T_G / 3_128945112_G_A
556	ZCCHC12_1	1166_QL-VIII-58_3	tor	1_1676790_C_T
557	MYL12B_3	294_MPS-1-IN-1_3	mitosis	2_108507561_T_G / X_38285780_G_A / 1_237687398_C_T
558	SHPRH_5	179_5-Fluorouracil_1	DNArep	11_65547388_T_G / 17_55774876_T_G / 2_108507561_T_G / 22_42212334_A_C / 13_113159942_A_G
559	NRSN1_4	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 9_93293047_T_G
560	HNRNPR_3	288_WHI-P97_3	other	17_40348252_T_G / 10_101004037_A_C / 17_73203001_T_G
561	RRAGC_2	263_FR-180204_3	erk_mapk	9_37887606_C_T / 10_79312556_A_G
562	CTSA_3	1012_Vorinostat_1	chromatin	11_12162199_T_G / 5_181155466_T_G / 16_87644643_G_A
563	DUSP26_3	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 15_43578884_A_G / 16_1817242_T_C
564	IFI35_2	294_MPS-1-IN-1_3	mitosis	11_12162199_T_G / 16_30953637_A_C
565	FAM163A_4	294_MPS-1-IN-1_3	mitosis	16_30953637_A_C / 6_33279455_T_G / 20_16044565_T_G / 2_113934259_C_T
566	DHX15_3	294_MPS-1-IN-1_3	mitosis	1_26774532_T_C / 19_3281403_A_C / 11_12162199_T_G
567	WDR86_3	305_TPCA-1_3	other	16_87644643_G_A / 20_42084724_T_C / 19_9566733_T_G
568	CECR5_1	1012_Vorinostat_1	chromatin	5_181155466_T_G
569	VASH2_1	1012_Vorinostat_1	chromatin	5_181155466_T_G
570	KCNH8_2	294_MPS-1-IN-1_3	mitosis	3_100302035_G_T / 2_169735166_A_C
571	MRPS25_3	179_5-Fluorouracil_1	DNArep	15_75524142_T_C / 9_37887606_C_T / 1_213007133_T_G
572	COPS7B_4	1012_Vorinostat_1	chromatin	10_11921140_T_G / 19_3281403_A_C / 1_150261398_T_G / 10_97048952_T_G
573	PHYHIPL_2	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 16_30953637_A_C
574	ATP6V0E1_3	294_MPS-1-IN-1_3	mitosis	12_40313960_G_T / 11_12162199_T_G / 15_43211582_A_C
575	CEP44_5	294_MPS-1-IN-1_3	mitosis	11_12162199_T_G / 10_11921140_T_G / 17_55774876_T_G / 11_65547388_T_G / 10_27223356_T_C
576	SEC22C_1	305_TPCA-1_3	other	15_65451964_A_G
577	TRIM38_2	294_MPS-1-IN-1_3	mitosis	15_43578884_A_G / 17_51169925_C_T
578	MTF2_1	1026_Tanespimycin_2	other	7_72942379_A_C
579	ZC3H15_4	263_FR-180204_3	erk_mapk	2_154854926_A_C / 7_149253814_T_G / 20_63929447_G_C / 3_196782572_G_T
580	THOC5_2	1012_Vorinostat_1	chromatin	1_54243266_A_G / 22_22098988_G_T
581	CLASP2_2	185_Linsitinib_2	igfr	9_37887606_C_T / 16_1817242_T_C
582	SLC18A2_2	294_MPS-1-IN-1_3	mitosis	16_30953637_A_C / 10_101004037_A_C
583	NDUFAF4_4	1012_Vorinostat_1	chromatin	11_65547388_T_G / 1_234373536_T_G / 15_65451964_A_G / 15_75524142_T_C
584	CHD4_1	1012_Vorinostat_1	chromatin	12_51745916_T_G
585	KIF5A_3	294_MPS-1-IN-1_3	mitosis	16_1817242_T_C / 11_12162199_T_G / 1_20724406_A_C
586	CNN2_2	294_MPS-1-IN-1_3	mitosis	11_12162199_T_G / 11_94082585_T_C
587	DCBLD1_2	294_MPS-1-IN-1_3	mitosis	10_26746549_C_T / 11_12162199_T_G
588	SPSB4_2	304_SB52334_3	rtk	15_55340661_G_T / 15_55329691_T_C
589	EDIL3_1	263_FR-180204_3	erk_mapk	11_12162199_T_G
590	GALNT10_3	294_MPS-1-IN-1_3	mitosis	6_30705792_T_G / 11_65547388_T_G / 12_40313960_G_T
591	H1FX_1	294_MPS-1-IN-1_3	mitosis	11_73355795_A_G
592	OSGIN1_4	275_I-BET-762_3	chromatin	4_61579528_T_C / 3_53871281_T_C / 3_53872486_G_A / 3_53888593_A_G
593	PRRX1_1	94_TGX221_3	pi3k	10_96527504_G_C
594	SERF2_1	1012_Vorinostat_1	chromatin	12_52013974_A_C
595	PPP1CC_3	1012_Vorinostat_1	chromatin	10_11921140_T_G / 1_185150475_G_A / 11_124896232_A_G
596	SYDE1_2	179_5-Fluorouracil_1	DNArep	11_65547388_T_G / 13_113159942_A_G
597	C11orf74_2	294_MPS-1-IN-1_3	mitosis	12_124473081_C_T / 19_17205202_T_G
598	NEFH_1	294_MPS-1-IN-1_3	mitosis	16_55415_T_G
599	MPPE1_2	294_MPS-1-IN-1_3	mitosis	1_160801918_G_C / 6_10410133_T_G
600	RAC3_1	281_Alectinib_2	rtk	20_42084724_T_C
601	XRCC2_1	1011_Navitoclax_2	apop	2_219297298_T_G
602	PVRL2_2	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 11_12162199_T_G
603	JAKMIP1_3	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 16_1817242_T_C / 6_33279455_T_G
604	RETSAT_2	305_TPCA-1_3	other	1_113900413_C_G / 10_43200831_A_G
605	ECSIT_4	1012_Vorinostat_1	chromatin	19_4911043_A_C / 2_60761746_T_G / 11_43920052_A_C / 12_6818898_A_C
606	KCTD11_5	263_FR-180204_3	erk_mapk	11_65547388_T_G / 14_93183653_A_C / 13_113159942_A_G / 1_54243266_A_G / 17_7797836_A_C
607	NOL4_1	294_MPS-1-IN-1_3	mitosis	16_30953637_A_C
608	PHACTR3_1	294_MPS-1-IN-1_3	mitosis	16_30953637_A_C
609	RTN1_1	294_MPS-1-IN-1_3	mitosis	16_30953637_A_C
610	STMN2_1	294_MPS-1-IN-1_3	mitosis	16_30953637_A_C
611	AP2S1_2	304_SB52334_3	rtk	2_61492168_C_A / 2_27774175_G_T
612	ZFYVE21_1	179_5-Fluorouracil_1	DNArep	22_42212334_A_C
613	UNC13A_1	1026_Tanespimycin_2	other	2_105307612_A_C
614	HRH3_2	294_MPS-1-IN-1_3	mitosis	3_128945112_G_A / 6_33279455_T_G
615	SLC46A3_1	275_I-BET-762_3	chromatin	11_12162199_T_G
616	FANCF_1	226_GSK1070916_2	mitosis	2_61492168_C_A
617	NUP188_1	1011_Navitoclax_2	apop	17_73203001_T_G
618	RASL11B_4	294_MPS-1-IN-1_3	mitosis	5_181155466_T_G / 11_73355795_A_G / 1_220067324_T_G / 9_126483890_T_G
619	RPL35A_1	253_XMD14-99_3	rtk	1_145961089_T_G
620	MRPS34_2	263_FR-180204_3	erk_mapk	6_32035203_A_C / 22_22098988_G_T
621	GIMAP2_3	179_5-Fluorouracil_1	DNArep	1_155709773_T_G / 16_87644643_G_A / 12_51745916_T_G
622	CEP290_2	305_TPCA-1_3	other	15_65451964_A_G / 12_57062993_T_G
623	GLTPD1_2	300_CX-5461_3	other	1_44339331_A_G / 9_37887606_C_T
624	GPHN_2	294_MPS-1-IN-1_3	mitosis	11_12162199_T_G / 13_39724512_C_T
625	CASP1_1	294_MPS-1-IN-1_3	mitosis	12_40313960_G_T
626	ZNF696_1	294_MPS-1-IN-1_3	mitosis	12_40313960_G_T
627	PUM2_1	294_MPS-1-IN-1_3	mitosis	19_3281403_A_C
628	MEIS1_3	179_5-Fluorouracil_1	DNArep	13_113159942_A_G / 17_36608462_A_C / 16_29836801_T_G
629	IFI30_1	269_NSC-207895_3	p53	16_55415_T_G
630	IL11RA_1	1012_Vorinostat_1	chromatin	10_11921140_T_G
631	NUCB2_1	1012_Vorinostat_1	chromatin	10_11921140_T_G
632	PTP4A3_1	1012_Vorinostat_1	chromatin	10_11921140_T_G
633	ADRBK2_2	294_MPS-1-IN-1_3	mitosis	11_65547388_T_G / 17_78476773_C_T
634	PKIG_3	156_AZD6482_2	pi3k	10_47523038_G_A / 10_46337735_A_G / 2_105307612_A_C
635	SET_2	1011_Navitoclax_2	apop	2_113934259_C_T / 7_44964464_T_C
636	FLII_4	294_MPS-1-IN-1_3	mitosis	12_51745916_T_G / 1_213007133_T_G / 16_1342948_A_C / 2_86027990_C_A
637	ARF6_1	300_CX-5461_3	other	1_173850301_T_G
638	HMGCR_1	294_MPS-1-IN-1_3	mitosis	16_1817242_T_C
639	ST8SIA3_1	294_MPS-1-IN-1_3	mitosis	16_1817242_T_C
640	UNC80_1	294_MPS-1-IN-1_3	mitosis	16_1817242_T_C
641	CCT8_3	1012_Vorinostat_1	chromatin	7_108024001_C_T / 8_61583890_T_A / 7_108023984_G_A
642	TRIM28_1	1012_Vorinostat_1	chromatin	19_40695973_T_G
643	CDC25A_2	1011_Navitoclax_2	apop	19_9566733_T_G / 14_55169342_TAAA_T
644	GLTP_2	1012_Vorinostat_1	chromatin	2_61492168_C_A / 1_149852603_A_G
645	CCDC77_1	1012_Vorinostat_1	chromatin	7_108023984_G_A
646	MCF2L_1	1091_BMS-536924_3	igfr	15_43578884_A_G
647	SLC6A2_2	294_MPS-1-IN-1_3	mitosis	16_1817242_T_C / 13_113159942_A_G
648	SYP_2	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 16_1817242_T_C
649	CNOT6_1	1012_Vorinostat_1	chromatin	15_75524142_T_C
650	VARS_1	1012_Vorinostat_1	chromatin	15_75524142_T_C
651	IFITM3_4	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 16_1817242_T_C / 7_149253814_T_G / 8_27431326_A_G
652	PEX5_1	1091_BMS-536924_3	igfr	2_96842345_G_C
653	SLC31A2_2	196_Phenformin_3	metabol	2_171833908_C_T / 2_171744206_C_A
654	GRIK3_1	294_MPS-1-IN-1_3	mitosis	3_128945112_G_A
655	VN1R1_1	294_MPS-1-IN-1_3	mitosis	1_213007133_T_G
656	TFB2M_1	1012_Vorinostat_1	chromatin	6_32002466_A_C
657	MAD2L1_1	1011_Navitoclax_2	apop	19_9566733_T_G
658	MCM7_1	1011_Navitoclax_2	apop	19_9566733_T_G
659	MLF1IP_1	1011_Navitoclax_2	apop	19_9566733_T_G
660	RFC3_1	1011_Navitoclax_2	apop	19_9566733_T_G
661	RPL13A_5	1012_Vorinostat_1	chromatin	4_145127510_C_T / 12_57470756_A_G / 15_45095024_A_C / 19_44985182_T_G / 20_47227145_T_G
662	LINGO2_5	221_TAK-715_2	jnk_p38	12_51745916_T_G / 17_737856_G_T / 10_74988957_T_G / 3_113344632_A_C / 4_173528913_A_G
663	DNAJC22_1	1011_Navitoclax_2	apop	15_75268724_T_G
664	LAPTM4B_5	1012_Vorinostat_1	chromatin	13_19425701_C_A / 7_117129719_T_G / 2_131597280_C_G / 1_54243276_T_G / 20_34850996_A_C
665	MRPL21_1	1012_Vorinostat_1	chromatin	22_22098988_G_T
666	KBTBD6_5	304_SB52334_3	rtk	11_65547388_T_G / 5_141478412_T_C / 13_113159942_A_G / 2_108507561_T_G / 6_30705792_T_G
667	ENDOD1_1	1012_Vorinostat_1	chromatin	5_80744593_A_C
668	DYNLT3_1	1012_Vorinostat_1	chromatin	16_70661204_T_G
669	FBXO33_3	253_XMD14-99_3	rtk	6_25488355_C_T / 6_25510468_CAT_C / 4_144114635_G_A
670	MAGT1_3	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 6_29631350_A_G / 10_11921140_T_G
671	RAP2C_1	253_XMD14-99_3	rtk	19_4911043_A_C
672	UNC13A_4	294_MPS-1-IN-1_3	mitosis	6_37282313_A_C / 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G
673	MFAP5_1	150_Bicalutamide_1	other	9_18775833_A_C
674	CUX2_2	294_MPS-1-IN-1_3	mitosis	11_12162199_T_G / 8_122952205_T_G
675	MED25_5	1012_Vorinostat_1	chromatin	17_18282776_T_G / 11_74492398_A_C / 19_1460944_T_G / 1_224418353_A_C / X_54813054_T_G
676	MYT1L_2	294_MPS-1-IN-1_3	mitosis	16_1817242_T_C / 15_43211582_A_C
677	TMEM18_2	176_IPA-3_3	cytoskeleton	2_54968084_G_A / 2_55027029_T_A
678	CCT7_1	1012_Vorinostat_1	chromatin	12_40313960_G_T
679	MAK16_1	1012_Vorinostat_1	chromatin	12_40313960_G_T
680	MRPS21_1	1012_Vorinostat_1	chromatin	12_40313960_G_T
681	POLR1B_1	1012_Vorinostat_1	chromatin	12_40313960_G_T
682	GTPBP1_2	333_T0901317_3	other	9_37887606_C_T / 11_43920052_A_C
683	EBF3_1	294_MPS-1-IN-1_3	mitosis	9_5549463_A_C
684	MTUS1_2	1012_Vorinostat_1	chromatin	19_53998273_G_A / 19_53999532_G_A
685	NUP133_2	179_5-Fluorouracil_1	DNArep	10_11921140_T_G / 11_12162199_T_G
686	CTNND1_2	294_MPS-1-IN-1_3	mitosis	6_30705800_T_G / 9_69516199_A_C
687	NDUFB9_1	1012_Vorinostat_1	chromatin	19_4911043_A_C
688	SLC9A7_1	1012_Vorinostat_1	chromatin	19_4911043_A_C
689	EIF4ENIF1_1	1091_BMS-536924_3	igfr	9_37887606_C_T
690	DOCK1_1	196_Phenformin_3	metabol	8_94407470_A_G
691	RPL32_1	300_CX-5461_3	other	8_12430448_C_T
692	PRICKLE2_1	185_Linsitinib_2	igfr	11_65547388_T_G
693	RUFY3_1	185_Linsitinib_2	igfr	11_65547388_T_G
694	WNT5A_1	185_Linsitinib_2	igfr	11_65547388_T_G
695	MPHOSPH10_2	275_I-BET-762_3	chromatin	15_75524142_T_C / 12_40313960_G_T
696	ARID3A_1	344_THZ-2-49_3	cell_cyc	8_7290003_A_C
697	HBQ1_1	344_THZ-2-49_3	cell_cyc	8_7290003_A_C
698	CAPG_5	305_TPCA-1_3	other	11_12162199_T_G / 10_11921140_T_G / 20_45938939_T_G / 1_156286332_T_G / 15_75783033_T_G
699	YARS2_2	1012_Vorinostat_1	chromatin	4_41632760_G_C / 4_41631305_C_A
700	KIAA0247_5	269_NSC-207895_3	p53	1_149852603_A_G / 17_55774876_T_G / 16_18379704_T_G / 7_114630022_T_G / 19_15191478_T_G
701	ATP6V1A_1	1012_Vorinostat_1	chromatin	9_69516199_A_C
702	NFXL1_3	179_5-Fluorouracil_1	DNArep	17_55774876_T_G / 1_228244520_T_G / 20_16044565_T_G
703	RIOK3_3	293_Amuvatinib_2	rtk	2_61492168_C_A / 19_4679822_A_C / 1_1918305_G_A
704	AKR7A2_4	281_Alectinib_2	rtk	1_213007133_T_G / 17_55774876_T_G / 17_15651252_T_G / 1_451649_A_AG
705	THOC1_3	305_TPCA-1_3	other	1_44804312_T_G / 17_5474687_A_C / 8_68625531_T_G
706	COPG_1	1026_Tanespimycin_2	other	6_26897081_G_C
707	RPL13_1	185_Linsitinib_2	igfr	20_42084724_T_C
708	ARRB2_2	179_5-Fluorouracil_1	DNArep	2_170965958_A_C / 20_33848655_A_C
709	CCDC41_2	269_NSC-207895_3	p53	9_86322936_ATTT_A / 9_86345023_C_T
710	WDR75_5	1012_Vorinostat_1	chromatin	3_196782572_G_T / 1_154331414_T_G / 7_149253814_T_G / 2_190469793_G_C / 18_14183954_G_T
711	LRBA_4	1011_Navitoclax_2	apop	13_114236659_T_G / 11_65547388_T_G / 2_178769713_G_T / 13_113159942_A_G
712	BAI3_2	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 6_30705792_T_G
713	FKBP4_1	1012_Vorinostat_1	chromatin	13_113325635_A_G
714	H3F3B_1	1012_Vorinostat_1	chromatin	13_113325635_A_G
715	LRRC45_1	281_Alectinib_2	rtk	17_6118065_A_G
716	VPRBP_1	1011_Navitoclax_2	apop	3_128945112_G_A
717	KIF1A_1	294_MPS-1-IN-1_3	mitosis	9_69516199_A_C
718	RPL3_1	294_MPS-1-IN-1_3	mitosis	2_24067801_G_A
719	ABI3BP_1	1012_Vorinostat_1	chromatin	16_87644643_G_A
720	FBRSL1_1	1091_BMS-536924_3	igfr	10_11921140_T_G
721	RAB3C_1	294_MPS-1-IN-1_3	mitosis	10_11921140_T_G
722	C16orf59_1	1012_Vorinostat_1	chromatin	19_9566733_T_G
723	NUP35_1	263_FR-180204_3	erk_mapk	19_9566733_T_G
724	LPIN2_1	344_THZ-2-49_3	cell_cyc	3_191357867_G_A
725	ZNF507_2	305_TPCA-1_3	other	11_65547388_T_G / 17_55774876_T_G
726	ADAM10_1	344_THZ-2-49_3	cell_cyc	17_63963708_T_C
727	FBXL18_1	344_THZ-2-49_3	cell_cyc	17_63963708_T_C
728	TMOD3_1	344_THZ-2-49_3	cell_cyc	17_63963708_T_C
729	HLCS_3	263_FR-180204_3	erk_mapk	14_67381608_G_T / 15_84241166_A_C / 17_43922689_A_G
730	NYNRIN_1	293_Amuvatinib_2	rtk	10_11921140_T_G
731	PDXK_1	344_THZ-2-49_3	cell_cyc	16_72164743_G_A
732	RPS11_3	1012_Vorinostat_1	chromatin	4_145127510_C_T / 17_28613683_A_C / 8_12430448_C_T
733	LCE2B_1	94_TGX221_3	pi3k	10_133753622_G_A
734	MAP2K7_3	1012_Vorinostat_1	chromatin	1_11243090_T_G / 12_109952676_A_C / 21_46245172_A_C
735	PATZ1_1	1012_Vorinostat_1	chromatin	11_12162199_T_G
736	SMCR7L_1	1012_Vorinostat_1	chromatin	11_12162199_T_G
737	CNTNAP2_1	196_Phenformin_3	metabol	8_7290003_A_C
738	SLC29A3_1	196_Phenformin_3	metabol	8_7290003_A_C
739	ZBTB34_1	185_Linsitinib_2	igfr	3_165019547_G_T
740	PRKAA1_2	294_MPS-1-IN-1_3	mitosis	X_100585180_G_T / 3_128945112_G_A
741	IRF1_2	294_MPS-1-IN-1_3	mitosis	17_55774876_T_G / 12_51745916_T_G
742	GDAP1L1_5	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G / 16_1817242_T_C / 11_125626705_T_G / 9_128835995_A_C / 7_20404680_T_G
743	NUP205_2	290_KIN001-260_3	other	15_78476214_A_G / 10_19491534_C_A
744	NUS1_1	1011_Navitoclax_2	apop	1_147618935_T_C
745	GOLT1B_3	344_THZ-2-49_3	cell_cyc	16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A
746	SEC24A_2	1026_Tanespimycin_2	other	15_28382572_T_C / 7_5308283_G_A
747	AVEN_1	94_TGX221_3	pi3k	7_75422659_A_G
748	BRD3_1	1011_Navitoclax_2	apop	2_113934259_C_T
749	CBX5_1	1011_Navitoclax_2	apop	2_113934259_C_T
750	ZNF689_1	1012_Vorinostat_1	chromatin	3_53183591_A_C
751	RHOG_5	1194_SB-505124_3	other	5_427675_T_C / 16_1817242_T_C / 13_113159942_A_G / 16_30398066_C_A / 2_121418676_T_G
752	SPRY1_4	224_AS605240_3	pi3k	3_121642799_G_A / 3_121634481_A_C / 3_121699918_T_C / 3_121642940_G_A
753	NR1H2_2	1011_Navitoclax_2	apop	1_154627925_A_C / 1_150261398_T_G
754	RTKN2_1	294_MPS-1-IN-1_3	mitosis	6_73644452_C_T
755	CHRNA5_1	294_MPS-1-IN-1_3	mitosis	6_10410133_T_G
756	PEBP1_1	1011_Navitoclax_2	apop	4_108762737_T_G
757	CNOT6_1	196_Phenformin_3	metabol	1_16589114_C_T
758	FEM1B_1	263_FR-180204_3	erk_mapk	1_151048750_A_C
759	PDCD2L_1	151_QS11_3	other	2_196880031_T_C
760	BCCIP_2	1012_Vorinostat_1	chromatin	1_219979389_T_A / 19_11402175_A_C
761	C17orf80_2	344_THZ-2-49_3	cell_cyc	16_72119226_C_G / 16_72129067_G_T
762	TMEM229A_1	1012_Vorinostat_1	chromatin	6_30705792_T_G
763	AKAP1_1	344_THZ-2-49_3	cell_cyc	16_72119226_C_G
764	EPC2_1	344_THZ-2-49_3	cell_cyc	16_72119226_C_G
765	FKBP14_1	344_THZ-2-49_3	cell_cyc	16_72119226_C_G
766	HMGB1_1	344_THZ-2-49_3	cell_cyc	16_72119226_C_G
767	TMEM167B_1	344_THZ-2-49_3	cell_cyc	16_72119226_C_G
768	FURIN_1	281_Alectinib_2	rtk	2_113934259_C_T
769	FUZ_2	1012_Vorinostat_1	chromatin	10_73803641_A_G / 17_6118065_A_G
770	RAX_1	94_TGX221_3	pi3k	14_64951601_A_C
771	HSPA5_1	344_THZ-2-49_3	cell_cyc	1_165652085_TATTATC_T
772	SEZ6_1	294_MPS-1-IN-1_3	mitosis	3_128879626_CGT_C
773	CDC7_2	1011_Navitoclax_2	apop	6_73622013_G_C / 6_73635330_C_T
774	TIMELESS_2	1011_Navitoclax_2	apop	2_218827668_A_C / 20_48700966_A_C
775	FAIM2_1	294_MPS-1-IN-1_3	mitosis	3_127621040_A_G
776	PKIA_1	275_I-BET-762_3	chromatin	13_113159942_A_G
777	MRFAP1L1_1	304_SB52334_3	rtk	11_12162199_T_G
778	SLC4A8_1	1011_Navitoclax_2	apop	6_33296240_C_A
779	SAMM50_1	344_THZ-2-49_3	cell_cyc	17_76009153_A_C
780	FAM129A_1	263_FR-180204_3	erk_mapk	13_113159942_A_G
781	AFMID_5	1012_Vorinostat_1	chromatin	14_70800628_C_T / 12_6941768_C_A / 11_12162199_T_G / 3_119147558_G_A / 3_196782572_G_T
782	STARD7_1	344_THZ-2-49_3	cell_cyc	21_31701881_A_G
783	GPN2_2	300_CX-5461_3	other	17_55774876_T_G / 1_451649_A_AG
784	PCDH9_1	344_THZ-2-49_3	cell_cyc	3_75669056_G_A
785	DDOST_2	344_THZ-2-49_3	cell_cyc	1_16589114_C_T / 6_10398408_A_G
786	TMEM109_3	179_5-Fluorouracil_1	DNArep	13_113159942_A_G / 16_30398066_C_A / 5_141102658_A_C
787	OLA1_2	196_Phenformin_3	metabol	1_148117837_C_T / 1_146969331_G_A
788	RGS3_4	344_THZ-2-49_3	cell_cyc	2_241748788_C_T / 2_241748877_C_T / 2_241751260_G_A / 2_241744700_T_C
789	HMGCL_1	344_THZ-2-49_3	cell_cyc	1_16589114_C_T
790	SIPA1L1_1	344_THZ-2-49_3	cell_cyc	1_16589114_C_T
791	TMEM50A_1	344_THZ-2-49_3	cell_cyc	1_16589114_C_T
792	AP2S1_2	196_Phenformin_3	metabol	7_100951952_T_A / 7_100951953_T_A
793	NARF_1	304_SB52334_3	rtk	5_83553308_T_G
794	S100A2_2	1011_Navitoclax_2	apop	11_65547388_T_G / 17_55774876_T_G
795	STX8_2	94_TGX221_3	pi3k	7_100951952_T_A / 7_100951953_T_A
796	SLC10A4_3	1011_Navitoclax_2	apop	6_30329265_T_C / 16_1817242_T_C / 12_51745916_T_G
797	KCNAB1_1	294_MPS-1-IN-1_3	mitosis	19_17205202_T_G
798	NUFIP1_1	294_MPS-1-IN-1_3	mitosis	1_112520503_A_G
799	PUS7_1	1011_Navitoclax_2	apop	11_65547388_T_G
800	TMEM33_1	1011_Navitoclax_2	apop	11_65547388_T_G
801	SUPT4H1_1	281_Alectinib_2	rtk	1_247949628_T_C
802	B4GALT1_2	185_Linsitinib_2	igfr	13_113159942_A_G / 11_65547388_T_G
803	TRMT1_1	344_THZ-2-49_3	cell_cyc	12_8176004_A_C
804	ITCH_1	344_THZ-2-49_3	cell_cyc	1_13281477_A_G
805	SLC41A2_1	1527_Pictilisib_2	pi3k	4_118640836_A_T
806	UBXN1_1	1091_BMS-536924_3	igfr	10_73803641_A_G
807	AARS2_1	293_Amuvatinib_2	rtk	2_211420614_AAAAG_A
808	ASB13_1	1012_Vorinostat_1	chromatin	17_28613683_A_C
809	CSDA_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
810	DBH_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
811	DOK4_1	185_Linsitinib_2	igfr	13_113159942_A_G
812	FAM57B_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
813	GRIA4_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
814	IGFBPL1_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
815	NFKBIZ_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
816	PIEZO1_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
817	SCN3B_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
818	SNAP91_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
819	TMEM151B_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
820	TRAM1_1	294_MPS-1-IN-1_3	mitosis	13_113159942_A_G
821	DLGAP2_1	294_MPS-1-IN-1_3	mitosis	6_33279455_T_G
822	GFRA2_2	1011_Navitoclax_2	apop	5_38950065_A_T / 16_30953637_A_C
823	C12orf44_5	1011_Navitoclax_2	apop	8_72935904_A_T / 8_23202743_T_C / 15_40296801_A_G / 8_23201811_C_G / 9_134768529_A_G
824	CPD_2	1091_BMS-536924_3	igfr	16_30953637_A_C / 9_108900415_C_A
825	UNG_3	1011_Navitoclax_2	apop	7_108023984_G_A / 4_70722781_C_T / 3_52437514_T_G
826	AGAP2_1	263_FR-180204_3	erk_mapk	10_77108446_G_A
827	DPY19L4_1	294_MPS-1-IN-1_3	mitosis	7_149253814_T_G
828	UST_1	294_MPS-1-IN-1_3	mitosis	4_70722781_C_T
829	MAP2K7_1	344_THZ-2-49_3	cell_cyc	1_16734496_C_T
830	DLG1_1	344_THZ-2-49_3	cell_cyc	3_197683305_A_C
831	MAPK8IP2_1	185_Linsitinib_2	igfr	6_25669441_G_A
832	TARDBP_3	1011_Navitoclax_2	apop	11_65547388_T_G / 22_42212334_A_C / 15_65451964_A_G
833	CYLD_1	294_MPS-1-IN-1_3	mitosis	17_40348252_T_G
834	ATL2_1	294_MPS-1-IN-1_3	mitosis	3_38112112_T_G
835	SCAMP5_1	294_MPS-1-IN-1_3	mitosis	X_100585180_G_T
836	ARL6IP5_1	196_Phenformin_3	metabol	14_102870248_A_C
837	TUBD1_1	276_CAY10603_3	chromatin	1_161021085_T_C
838	OLFM3_1	294_MPS-1-IN-1_3	mitosis	10_43200831_A_G
839	ODC1_2	310_YM201636_3	other	1_44339337_G_A / 15_75524142_T_C
840	EXOSC8_4	1011_Navitoclax_2	apop	6_73622013_G_C / 6_73635330_C_T / 2_127651579_A_C / 6_30705792_T_G
841	GEMIN5_4	1012_Vorinostat_1	chromatin	9_104837455_A_G / 8_42401781_A_G / 1_46261223_G_A / 15_72662708_A_C
842	BCLAF1_1	269_NSC-207895_3	p53	11_65547388_T_G
843	ADAMTSL2_3	294_MPS-1-IN-1_3	mitosis	14_20996722_T_G / 8_122952205_T_G / 9_136745293_A_C
844	GSDMD_1	196_Phenformin_3	metabol	8_143559981_G_GAGGGCAGGGC
845	FILIP1L_1	344_THZ-2-49_3	cell_cyc	2_117977926_TAGTC_T
846	MPP5_1	344_THZ-2-49_3	cell_cyc	16_10941900_CGAA_C
847	ZNF781_2	1011_Navitoclax_2	apop	6_30705792_T_G / 11_65547388_T_G
848	GREB1_1	294_MPS-1-IN-1_3	mitosis	11_65547388_T_G
849	MICAL2_1	294_MPS-1-IN-1_3	mitosis	11_65547388_T_G
850	MLKL_1	304_SB52334_3	rtk	17_55774876_T_G
851	HIATL1_1	333_T0901317_3	other	1_13816508_A_G
852	POFUT2_3	344_THZ-2-49_3	cell_cyc	16_72119226_C_G / 16_72164743_G_A / 7_95495738_CT_C
853	FSD1L_3	1011_Navitoclax_2	apop	13_113159942_A_G / 11_12162199_T_G / 11_65547388_T_G
854	SLC22A4_1	294_MPS-1-IN-1_3	mitosis	2_60761746_T_G
855	ECE1_1	344_THZ-2-49_3	cell_cyc	3_196484004_T_C
856	FAM120C_1	179_5-Fluorouracil_1	DNArep	1_206458298_T_G
857	WDR18_1	1012_Vorinostat_1	chromatin	1_64663808_A_C
858	SPAST_2	305_TPCA-1_3	other	14_68291858_T_C / 4_158607939_A_AT
859	RIN2_1	344_THZ-2-49_3	cell_cyc	2_15474280_T_C
860	RUNX2_2	185_Linsitinib_2	igfr	11_12162199_T_G / 15_75268724_T_G
861	NOP14_2	1012_Vorinostat_1	chromatin	17_3513849_GCA_G / 9_36058818_G_T
862	MAN2B2_1	1012_Vorinostat_1	chromatin	17_55774876_T_G
863	PAIP1_1	344_THZ-2-49_3	cell_cyc	1_112659795_G_A
864	DHX32_2	344_THZ-2-49_3	cell_cyc	X_119469587_A_G / X_119451980_A_G
865	PLK2_2	344_THZ-2-49_3	cell_cyc	3_9688859_C_T / 5_127331576_G_A
866	PRCC_1	1012_Vorinostat_1	chromatin	4_9908299_G_A
867	XAF1_1	344_THZ-2-49_3	cell_cyc	2_197498780_A_G
868	METAP2_1	344_THZ-2-49_3	cell_cyc	2_208237181_GA_G
869	CLK2_1	294_MPS-1-IN-1_3	mitosis	2_230875561_A_G
870	DPP6_1	294_MPS-1-IN-1_3	mitosis	19_43375573_G_T
871	ACSL4_3	344_THZ-2-49_3	cell_cyc	11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G
872	ANKIB1_1	1012_Vorinostat_1	chromatin	2_218827668_A_C
873	MRPL44_1	263_FR-180204_3	erk_mapk	10_11921140_T_G
874	ECSIT_1	344_THZ-2-49_3	cell_cyc	2_105307612_A_C
875	UTRN_1	344_THZ-2-49_3	cell_cyc	2_105307612_A_C
876	KLHL3_1	94_TGX221_3	pi3k	3_10062127_TA_T
877	PPP3CC_1	1011_Navitoclax_2	apop	15_77916965_T_C
878	ZNF146_2	276_CAY10603_3	chromatin	13_113159942_A_G / 3_196782572_G_T
879	ZNF561_1	156_AZD6482_2	pi3k	2_9954863_A_G
880	GABRB3_2	196_Phenformin_3	metabol	2_15474280_T_C / 2_15534562_T_C
881	FUCA2_2	294_MPS-1-IN-1_3	mitosis	1_185150475_G_A / X_54813054_T_G
882	ZNF704_1	196_Phenformin_3	metabol	11_120836935_C_T
883	RSRC2_1	179_5-Fluorouracil_1	DNArep	11_43920052_A_C
884	ZNF786_4	1166_QL-VIII-58_3	tor	16_72119226_C_G / 16_72164743_G_A / 16_72129067_G_T / 16_72150667_C_T
885	FAM208A_4	344_THZ-2-49_3	cell_cyc	1_103021838_CT_C / 8_7290003_A_C / 1_103002059_C_T / 1_102989661_C_T
886	KLC1_2	179_5-Fluorouracil_1	DNArep	6_30705792_T_G / 9_35801627_T_G
887	C4orf46_1	1011_Navitoclax_2	apop	1_44804312_T_G
888	PFDN2_1	1012_Vorinostat_1	chromatin	1_200988322_T_G
889	TMEM88_1	304_SB52334_3	rtk	15_63286530_C_T
890	CAMKMT_1	1009_Tretinoin_1	other	3_165019547_G_T
891	RAB3A_5	1091_BMS-536924_3	igfr	1_149852603_A_G / 15_75293000_T_G / 16_15664675_G_T / 1_150261398_T_G / 13_113325635_A_G
892	PPP1R3C_1	1012_Vorinostat_1	chromatin	1_172308705_AT_A
893	RNPS1_1	1012_Vorinostat_1	chromatin	6_26033581_T_TAAG
894	SESN1_1	185_Linsitinib_2	igfr	8_93815432_A_C

Results of verification of biomarker responsiveness to brain tumor drugs

No.	FRH	Var_Exp (pval)	Var_Drug (pval)	Exp_Drug (pval)	Ave_VarDrug (pval)	Rank
One	PTRF_9	2.02E-17	0.000749693 / 0.000426098 / 0.009328967 / 0.000372589 / 0.006511221 / 2.35E-11 / 0.000116605 / 0.001047505 / 0.001374062 / 0.001565845 / 0.006047479 / 7.32E-05 / 0.006557575 / 9.01E-05 / 0.000574879 / 0.000160684 / 2.49E-05 / 0.002310424 / 0.000331474 0.000819278 / 9.28E-12 / 0.002957218 / 0.007844904 / 0.002619813 / 0.000685764 / 3.28E-05 / 0.007149858 / 1.82E-05 / 0.004659546 / 0.004062417 / 0.000187819 / 2.07E-07 / 0.004167431 / 0.001265165 / 0.002575563 / 0.000839515 / 0.008965476 / 0.00033059 4.72E-05 / 0.001888735 / 0.00646848 / 0.000714169 / 2.80E-07 / 0.001294695 / 0.000115716 / 3.08E-06 / 0.000261232 / 0.001910231 / 1.28E-06 / 0.004145356 / 0.003060428 / 0.006977625 / 0.001419304 / 7.63E-09 / 0.009439533 / 0.003871906 / 0.00072755 / 3.06E-06 / 0.003623857 / 0.001340666 / 0.008077047 / 0.000197417 / 0.003726859 / 0.001744921 / 0.006814012 / 0.007768596 / 0.001018135	8.86E-05 / 0.015861427 / 0.000935884 / 6.69E-06 / 0.001642604 / 7.15E-09 / 0.000114128 / 0.005567682 / 0.001713376 / 0.003771243 / 0.001845691 / 6.63E-05 / 0.000313526 / 0.002067719 / 0.000456029 / 0.003684593 / 5.74E-06 / 0.002204168 / 0.000228633 / 0.000400518 / 6.03E-07 / 0.000743512 / 0.012226314 / 0.024250323 / 8.17E-07 / 0.000107275 / 0.068108214 / 1.05E-05 / 0.245827021 / 0.000690655 / 0.00029549 / 3.30E-06 / 0.000963538 / 0.000798032 / 0.000737892 / 0.005284786 / 0.00534 / 8.80E-05 / 0.004403153 / 0.004222642 / 0.006563798 / 0.000101882 / 5.52E-08 / 0.000895926 / 4.32E-06 / 2.39E-05 / 0.012076982 / 0.000700794 / 4.02E-08 / 0.000551546 / 0.005498224 / 0.005843004 / 0.004771885 / 7.03E -09 / 0.000449732 / 0.00773881 / 0.00481047 / 2.17E-06 / 0.029515032 / 2.54E-05 / 0.001228246 / 0.001095519 / 0.018900662 / 0.000306042 / 1.61E-05 / 0.007260065 / 0.036785468	0.00244	67
2	MBTD1_5	0.0000000000	6.079058529181583e-06 / 0.000330234961590499 / 0.0009065836837091153 / 7.743250099097525e-08 / 5.4243318683013945e-06 / 6.638871076180972e-05 / 0.0001034540386175869 / 2.742943691390761e-05 / 8.864763064813537e-07 / 2.0409106 / 0.001580303435076526 / 0.00012171542819902834	2.8823341263186404e-09 / 7.828409458693464e-09 / 8.294895004123309e-09 / 3.2262810582910645e-08 / 1.8139300001511646e-07 / 1.8402518116440838e-07 / 2.67841045277985e-07 / 1.5039088850140218e-06 / 1.3222940844102726e-06924 0.00019219761010832952 / 8.314417317729093e-07 / 1.370078882045095e-05 / 6.768156840167973e-06 / 1.0455349186526601e-05 / 2.2476152083519155e-06 / 3.022593119181365e-06	0.000545	17
3	C12orf29_4	0.0000000000	4.824002117845577e-08 / 0.005441831791967279 / 1.1897498080889868e-05 / 2.832726371483715e-06 / 3.554190719208408e-05 / 9.98122338478244e-05 / 0.00019780761336601855 / 1.2166594948453657e-06 / 0.0013399032530365647 / 0.010366551109197954	9.831623775837906e-08 / 1.1424232521759333e-06 / 4.317636814226818e-05 / 1.4382106269639384e-06 / 1.565031148370116e-06 / 0.0001061775620019226 / 7.880009857538694e-07 / 5.059091238516106e-06 / 6.9124096914811e-05 / 3.74550652948	0.00175	10
4	DDX20_1	0.0000010604	9.390951294242489e-05 / 0.003291125326808141 / 6.606509042863372e-05 / 0.0009706006123489501 / 0.00033173858745018413 / 2.8301251379202592e-05 / 0.002989009151291833 / 0.0003464118358647972 / 4.611763366846969e-05 / 0.010271987936204268	1.8690130781974698e-08 / 1.7049356788275527e-06 / 4.90739703689557e-07 / 2.1664146971003018e-07 / 2.2579476817862133e-07 / 2.2223004763773554e-07 / 1.487681859612425e-06 / 5.806089896300099e-06 / 5.518438170954557e5707	0.001844	10
5	TACC1_4	0.0000000000	3.87018819160593e-07 / 7.839796663490128e-06 / 0.0211517389620851 / 0.0007385583772737821 / 0.0001541124146376614 / 0.000740753187661269 / 0.00010956462066226552 / 0.0005066082079176534 / 0.00031180764933246263 / 0.0002656005692813481	1.8794101118497154e-10 / 5.932840218364882e-08 / 1.3308222183335375e-05 / 3.6611240087061e-07 / 1.9891885346261133e-06 / 2.780203755383467e-06 / 7.920522224234305e-06 / 4.233437731609824e-05 / 1.3783248323482445e-06 / 8.7150024158	0.002399	10
6	SFPQ_1	0.0000000779	4.611763366846969e-05 / 6.606509042863372e-05 / 9.390951294242489e-05 / 0.0021892065422244767 / 0.002989009151291833 / 2.8301251379202592e-05 / 0.006770110957154303 / 0.003291125326808141 / 0.00018869114988485987 / 0.023379270483941148	1.6421685468372866e-11 / 2.7347777767986492e-08 / 6.012098925210058e-08 / 2.202165084592466e-05 / 9.663054308166113e-05 / 8.127505856380939e-07 / 1.0837751787086504e-05 / 8.284871105188379e-05 / 1.8339230937241138e-06 / 7.70485657	0.003904	10
7	LRPPRC_2	0.0000000013	1.2022019578742027e-05 / 0.0003761548279529811 / 0.0037244088642669265 / 0.0021708592883619747 / 0.0001663224278721914 / 0.023108708224531857 / 2.9430765473148166e-05 / 0.01050357293743899 / 0.020115537840238746 / 0.010524107924498233	5.209483330257566e-10 / 8.01050796462614e-08 / 2.4695473842016646e-07 / 8.371111187295495e-08 / 5.106669850809745e-07 / 4.686091200519956e-06 / 1.3349886552198077e-08 / 1.915969698573113e-06 / 2.9107217405524718e-0697 2.599767	0.007073	10
8	ILF3_5	0.0000000000	1.3887956173777372e-05 / 1.6939519588941488e-05 / 9.786382578515826e-08 / 0.0007340541171379744 / 3.1279199929494124e-06 / 9.697231213241931e-06 / 0.0003946275449128456 / 0.0013987772568790748 / 0.0011249003808451194	1.7515743716180326e-07 / 3.0845658986771253e-07 / 6.542843309537432e-09 / 1.1331609020935322e-06 / 4.268164739909969e-07 / 1.315856013252508e-05 / 7.875046335838071e-06 / 4.114385321933064e-07 / 2.3594761771202245e-05	0.000411	9
9	ATXN7L3B_5	0.0000000000	2.612066597760477e-06 / 0.00011479613384953161 / 7.334368900690378e-11 / 0.0010577852528073678 / 9.018479144369487e-06 / 9.409687610838478e-05 / 0.003583481340909988 / 1.7599872572764645e-05 / 0.0008387169638839557	2.969448250016487e-08 / 1.9600165258234536e-07 / 4.2990302404127387e-08 / 2.1159749013263597e-06 / 1.0277412362510468e-05 / 2.2327592321063564e-05 / 2.749246019785697e-06 / 2.702131319979186e-05 / 6.193347041468136e06	0.000635	9
10	CENPV_1	0.0000001156	0.006820424547488444 / 1.2412020538304333e-05 / 0.004148676908553548 / 0.005770181686062503 / 0.019668015814206605 / 0.0025299472548494955 / 0.005078710464709388 / 0.0004338260851758113 / 0.03879612345050204	1.6083375617695613e-06 / 1.8297985260415566e-08 / 5.676604686582581e-08 / 4.561722639281827e-07 / 2.7263615702723626e-06 / 6.194080837624687e-07 / 1.2533181199972694e-06 / 0.00011131713990719029 / 4.864543347378877e-07	0.009251	9
11	CAMKV_4	0.0000000014	5.551416714792332e-06 / 0.0008366625106022517 / 0.0005748885432290085 / 2.2091746366723067e-05 / 0.0012478612516330242 / 0.0013687527180138105 / 1.5647557069044988e-05 / 5.021668210368932e-05	4.61338946784834e-09 / 8.552882219336728e-06 / 1.2084936819520143e-05 / 7.064438585065973e-06 / 0.0003375551467252637 / 1.1640523808727713e-05 / 7.01115214482234e-05 / 4.699480658072907e-05	0.000515	8
12	TPMT_3	0.0000000000	7.28786952864283e-07 / 3.56646279188718e-05 / 9.6666658281473e-06 / 0.000778043526031782 / 0.0009044201128473978 / 0.0021692955083051683 / 0.0005370416183224255 / 9.028956735669806e-05	1.4274492942468779e-08 / 1.0767623030922322e-08 / 5.322824205944157e-10 / 6.914371271776401e-08 / 3.193252019194024e-06 / 3.3380153156051058e-06 / 1.3843642927526513e-06 / 1.514974348380039e-05	0.000566	8
13	WASF1_3	0.0000000001	3.6965068162525554e-06 / 0.0012954933098786366 / 1.5026939104998247e-05 / 6.092048706938309e-06 / 5.7827307263502816e-05 / 3.710694976569371e-08 / 2.4065055735879793e-06 / 0.0066209312465568835	1.8963621043904114e-06 / 1.942674022825637e-09 / 1.4008670359077526e-07 / 7.984757203592169e-07 / 1.807601980567127e-06 / 1.014708711120146e-06 / 9.411427127533182e-07 / 2.7376810453016147e-06	0.001	8
14	DDX25_4	0.0000000000	4.227069860488674e-06 / 1.1933180927019854e-06 / 1.275889510970952e-05 / 0.00014312717982028765 / 0.0001971578481272282 / 0.0007128346948758641 / 0.005660294390019774 / 0.002987411679461687	5.868503968366881e-07 / 1.6672256393335718e-07 / 7.607024358338446e-07 / 4.007532632723821e-06 / 5.422908721198046e-06 / 4.226087433911996e-06 / 1.9844578914555127e-05 / 1.348050130807739e-05	0.001215	8
15	ACVR2B_5	0.0000000000	0.00031701458152281776 / 4.014660005410256e-05 / 8.837943468799988e-05 / 1.2223170855538867e-05 / 0.00417544874823594 / 0.00027313653971257405 / 0.006738885955615125 / 0.00033890163674631904	4.22669945715201e-07 / 7.742783641708327e-10 / 2.0483971869730718e-07 / 1.239958147162055e-07 / 4.939171357902516e-05 / 4.120212263097594e-06 / 0.0006361321771264191 / 2.7380093694423655e-05	0.001498	8
16	TAP1_4	0.0000000000	1.049031460757783e-06 / 0.0003635757182364942 / 3.753398348762388e-07 / 0.00028733812150622895 / 0.0007167010349785833 / 2.307106816252697e-05 / 5.337901424957087e-05 / 0.020106125155811467	1.3332679478124245e-07 / 1.1868875335385447e-05 / 2.7070790605645726e-06 / 7.056569159589176e-06 / 0.0002157049138716117 / 4.445857267298034e-06 / 3.642358929245767e-05 / 2.406762142831913e-06	0.002694	8
17	SMPD1_1	0.0000009495	0.003065043011644369 / 0.0023157697041580965 / 0.0012909968347916095 / 0.0006256240573576323 / 0.007223252257555813 / 0.03771188975485943 / 0.0003890294490866307 / 0.00736333395639105	5.955099761237206e-13 / 3.051847715980306e-09 / 1.8525537737343062e-08 / 6.490954203776185e-06 / 9.743943487605562e-08 / 1.3599979831920288e-06 / 8.962608566425138e-06 / 5.6013193436695554e-06	0.007498	8
18	PEA15_5	0.0000000000	0.0002596888575908078 / 0.0013300138356594274 / 0.00524721075079139 / 0.006442952776112118 / 0.018912868681800837 / 0.01937026642721713 / 0.01438287077969559 / 0.0004932314709699339	4.44845454863038e-09 / 1.0130302320647733e-07 / 4.515074038541242e-07 / 2.962208123523371e-06 / 1.8659873824466947e-06 / 2.323546008318182e-06 / 2.7318856566845997e-06 / 1.1792288071015321e-05	0.008305	8
19	SLC25A43_1	0.0000001166	0.0012903447119515423 / 0.004158933151515996 / 0.008351774878422811 / 0.04843122350083363 / 2.540557327027098e-05 / 0.0003105144729205529 / 0.010869042090733612 / 0.02588573867516253	1.891414179412052e-09 / 2.1049137124860745e-07 / 5.230089820717235e-09 / 8.635969388699494e-07 / 5.5411681205887995e-08 / 7.317272575393834e-07 / 4.148735135683505e-07 / 3.228573281191034e-05	0.012415	8
20	MT2A_5	0.0000000000	0.00011447752236282417 / 0.0002544633476725284 / 0.00017859214428829218 / 0.0005165077368872941 / 0.00014503469256866046 / 0.000601999882354011 / 9.573116134444548e-05	1.584500848087154e-07 / 2.51478016245715e-07 / 8.54720361712193e-07 / 6.516915144267419e-06 / 5.171536692079251e-06 / 8.802100259189991e-06 / 1.6314636428146748e-06	0.000272	7
21	RUNX1_2	0.0000000000	0.0005559642828812122 / 0.0008971360026655244 / 0.0009701318251119559 / 1.7922091488637388e-05 / 0.00017935064903782676 / 0.0025863116474804755 / 0.0001657906685047857	1.9576595780585085e-10 / 2.1776070811919277e-07 / 7.527037299722958e-07 / 2.559009185958782e-07 / 2.2176040120466972e-05 / 2.5598942326458564e-06 / 8.17316116112682e-06	0.000768	7
22	LRRC8B_3	0.0000000000	9.4941920370122e-06 / 0.0015781807884715357 / 0.0002622885842506721 / 0.0011548969209222207 / 0.005697781111749079 / 7.700053244511214e-06 / 0.001483718198167863	4.296394955066174e-08 / 1.4324682153058617e-05 / 1.7104030080984345e-05 / 7.565682931060495e-07 / 1.624606018039645e-05 / 4.1115916939474605e-06 / 5.004433338367946e-06	0.001456	7
23	PSMB9_4	0.0000000000	1.1255116843939685e-06 / 7.444306538180959e-05 / 8.121302745530734e-05 / 0.006696643814464557 / 0.0001492527064854631 / 4.25829047419839e-06 / 0.003283436953926786	5.9405281136078796e-08 / 4.799096156918887e-07 / 6.170625684612102e-06 / 1.4805988081664244e-06 / 1.6676304471263215e-05 / 2.337476084860884e-05 / 2.138799423764577e-05	0.00147	7
24	RRAS_5	0.0000000000	8.182509603383713e-07 / 0.00021369162894747652 / 0.003190351183802246 / 0.00679937164887004 / 9.99040056201094e-06 / 0.002342765582078353 / 0.00018160002648956962	2.876707427462528e-08 / 6.680110293230449e-07 / 5.972855062819303e-07 / 2.8451937899285467e-05 / 7.687368595573398e-06 / 7.477786594755585e-07 / 1.3224569563917872e-06	0.00182	7
25	TMBIM1_5	0.0000000000	2.322967022611346e-06 / 4.188818420450373e-05 / 8.859519927799691e-07 / 6.20461992462773e-05 / 0.00026413620242118544 / 0.00014398625006041495 / 0.014948105524536974	9.353599152353929e-08 / 5.844591678215266e-07 / 1.5978510581326625e-07 / 9.291490547025219e-07 / 2.7475634725757366e-07 / 4.753956509088212e-05 / 9.311198865860414e-07	0.002209	7
26	KLHL23_3	0.0000000004	0.00012805365107500054 / 0.002519598458842781 / 0.0004515536091125032 / 0.00022680614492479574 / 0.009733620762754698 / 0.0042912100983332774 / 4.9219858574682586e-05	9.921726897145688e-09 / 8.717866079599918e-06 / 8.841783359385233e-07 / 1.1383657613478495e-06 / 0.0008824236923248849 / 3.398353518910182e-05 / 5.795994893765768e-07	0.002486	7
27	EWSR1_1	0.0000005663	2.098169823270148e-06 / 0.00920357999307954 / 1.7711409436331332e-05 / 0.0014863302195178008 / 0.0014863302195178008 / 0.005409509534570436 / 1.9786173221795818e-05	4.043867582082559e-07 / 8.844612889243844e-05 / 2.099411528051961e-06 / 6.37244282155154e-05 / 3.479676125457968e-06 / 4.563731385373264e-06 / 8.51275649150399e-06	0.002518	7
28	ZNF124_3	0.0000000174	0.01185115455025083 / 0.0028820143512348784 / 0.0006400036981941583 / 0.00022237327343913756 / 0.0017326407356747695 / 0.0002237032245520265 / 0.0002896824687842766	3.830190864530467e-08 / 0.0005023437846254026 / 1.4341269466072291e-05 / 1.9187040433353085e-05 / 3.0536343957588886e-05 / 0.00015912558081257976 / 0.00030057122653906633	0.002549	7
29	CAPG_2	0.0000000000	0.00016360654996415964 / 0.003107700700013517 / 0.004526868535758527 / 0.003825441026009639 / 0.00040288084200566923 / 3.2262553686676067e-08 / 0.006275421665752097	1.6061695068770962e-09 / 6.708972026453563e-07 / 6.9252484921311626e-06 / 8.27034474165013e-06 / 9.342485200961395e-05 / 8.711780875641735e-07 / 5.302432363858073e-06	0.002615	7
30	TGOLN2_2	0.0000000030	0.0002870649623628604 / 0.005727463389908907 / 1.203780953398585e-06 / 0.00027661203249205183 / 0.0005689555709178733 / 0.0006501827815986053 / 0.014330254737635668	3.619262458649237e-11 / 4.769486326622182e-08 / 1.6622051928852046e-08 / 3.6038229751219804e-07 / 4.940074588134348e-05 / 1.8592574634706461e-06 / 7.392344957282081e-05	0.00312	7
31	RBFOX1_1	0.0000008465	0.0006456808009902826 / 0.0009805618383529596 / 0.0005802206884848052 / 0.0007177403550416762 / 0.00731321321837694 / 0.0011231690936696782 / 0.010617152378270862	2.2848739279053027e-11 / 3.403410943591806e-08 / 5.3253671669888775e-06 / 5.391441835390658e-06 / 9.82032865139159e-07 / 4.249582206860703e-06 / 4.042294162166094e-06	0.00314	7
32	RANBP2_2	0.0000000020	0.0032005645957622507 / 1.1292974727160135e-05 / 0.004582586266801288 / 0.005968942599275744 / 0.0007669246686613953 / 0.0003836018962680972 / 0.01256992621275457	1.0278781040318966e-06 / 3.2181914215686755e-07 / 9.03950843772086e-07 / 2.2352937628807305e-06 / 1.2237851910310582e-05 / 2.3260388622347645e-06 / 3.157729990156927e-05	0.003926	7
33	CCT2_1	0.0000000610	0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.00028286232014178015 / 0.008201744521300066 / 0.002944369153927747 / 0.01649068093735444	1.2749486030115433e-08 / 1.1225851282580173e-07 / 6.873884305086476e-09 / 2.2752402825301866e-07 / 1.0015662188091184e-06 / 3.453963505596524e-06 / 5.058184693460015e-06	0.00431	7
34	CEP95_2	0.0000000004	0.0007190070321581675 / 0.0002545171218429651 / 0.0035966015072663835 / 0.0025521170193974763 / 0.0003107381669592285 / 0.027502917617089746 / 0.0012110736028058307	1.3949676285490207e-07 / 2.1170919481613956e-08 / 2.8596627227079915e-05 / 9.032373803983716e-08 / 4.00753265620622e-06 / 6.457362557632581e-06 / 4.791358118111102e-07	0.005164	7
35	GINM1_3	0.0000000000	2.8556636750809756e-05 / 0.00012092027077076626 / 0.004350456289105647 / 0.0028744599511057625 / 0.009781859661254071 / 0.012315629622740824 / 0.014183888091677869	3.741940140138828e-09 / 6.30551384179601e-07 / 5.723523849148954e-07 / 4.137409181237638e-07 / 4.058957920972812e-06 / 1.324094056480911e-05 / 5.334206696833551e-06	0.006237	7
36	POLG2_2	0.0000000067	0.0002576770516093337 / 0.0016833422652258513 / 0.01537032415812942 / 0.0199546774517756 / 0.011879693396648705 / 0.013778504455704959 / 0.0006073423559504219	8.002612553216828e-12 / 2.5154718511604325e-07 / 5.542657615241579e-07 / 6.569612124521097e-06 / 5.133965042123324e-06 / 4.188709032414043e-08 / 6.35362381394998e-07	0.009076	7
37	RAN_2	0.0000000007	8.10356681117687e-05 / 0.0015745833133913741 / 0.0003323999875867436 / 0.014323464285551478 / 0.003484183595989438 / 0.0003293358901815535 / 0.045671136243731716	4.467053904818645e-09 / 8.90912425766829e-06 / 2.7276695958874614e-07 / 1.6612137127547922e-06 / 4.295327136339735e-06 / 0.00010945540484186873 / 0.0007487722885105004	0.009399	7
38	MTF2_2	0.0000000001	0.00024102538797346086 / 0.001539940029122352 / 0.005818462625160796 / 0.04331587497952318 / 0.003473006180561586 / 0.013123198329328149 / 0.0011086944827796786	5.524058788809012e-07 / 2.255174371885246e-07 / 1.0230509628865922e-08 / 1.5272339234163363e-06 / 4.502242650312079e-06 / 1.4470801258175914e-06 / 4.0947329724111495e-06	0.009803	7
39	CMPK1_1	0.0000099465	0.01615823448153983 / 0.03373282648472924 / 0.016556829420777325 / 0.01344459083967992 / 0.0011586570434241133 / 0.007942503974326632 / 0.006386843886902124	2.364261967442666e-08 / 5.989349364171967e-07 / 1.051890467879646e-07 / 2.8069595654757565e-06 / 2.675202019953556e-06 / 4.952772665629785e-06 / 8.5101324606656e-06	0.013626	7
40	MDN1_1	0.0000149331	0.027136920905959004 / 0.015382714940475899 / 0.0002021790532799894 / 0.025082579510674555 / 0.002667939855033078 / 0.01903033340546255 / 0.023433853775319136	3.1384912120068307e-10 / 9.325247533918398e-06 / 6.936897377329882e-07 / 2.353698101267621e-06 / 1.4783005405825795e-05 / 1.3845703258818903e-06 / 3.794277797288223e-07	0.016134	7
41	INPP1_2	0.0000000458	0.00012405403034171616 / 1.718785742696879e-05 / 6.396622257100077e-06 / 6.925570695765487e-06 / 3.9200560425745034e-05 / 1.2385564215356241e-06	5.3962567655992866e-05 / 8.480907105422951e-07 / 2.8149687924382837e-07 / 6.886821060328188e-06 / 4.946024817438151e-06 / 2.5531357893982e-06	3.25E-05	6
42	TOMM20_5	0.0000000000	9.847481167714172e-07 / 5.461787394016582e-07 / 2.630785074908594e-05 / 6.807575706103957e-07 / 6.31788143549132e-07 / 0.0002787072964560934	1.828485836400758e-09 / 8.488593461887543e-08 / 4.561158256034957e-06 / 1.357508261446604e-07 / 2.9348649605847958e-06 / 1.3733983916997187e-05	5.13E-05	6
43	S100A6_3	0.0000000000	3.987563090636182e-09 / 6.751332523310354e-08 / 5.131148780828573e-06 / 5.346137072472972e-07 / 0.0008192357956865613 / 1.657842655825674e-06	1.8859563430955987e-09 / 1.5597048970633669e-07 / 6.731790637644895e-07 / 3.923562825747655e-06 / 7.57844698984901e-05 / 1.7516083103081196e-06	0.000138	6
44	ZNF74_5	0.0000000000	7.220170669604226e-07 / 0.000560135938998767 / 3.1675474781598684e-05 / 0.0005276313183088553 / 2.1660265856759415e-06 / 0.00015601716830048032	1.4629848729112387e-07 / 1.1761012404538385e-06 / 4.011024961679582e-05 / 2.0573826720469716e-06 / 2.0056325015251253e-05 / 3.125081554604303e-05	0.000213	6
45	ZNF195_3	0.0000000000	4.2041150573934295e-05 / 4.5529669866602804e-05 / 0.0007203033990971563 / 0.00014468246920967197 / 0.00031951653993607604 / 8.595632585615447e-05	6.719675625838534e-09 / 3.8056480729458196e-09 / 7.723330075061024e-07 / 3.1795531703660226e-06 / 4.735362185795e-06 / 1.0975067398076295e-06	0.000226	6
46	DNMT3A_2	0.0000000000	6.115665040218944e-06 / 3.206324028832219e-05 / 8.429951747175733e-05 / 0.00019962122279230926 / 5.615553156462022e-07 / 0.0021806139002983004	1.511429559536217e-08 / 3.3834848660671585e-06 / 1.0925063596049997e-07 / 6.95434985454603e-08 / 4.9915249752075324e-06 / 2.7418564056278035e-05	0.000417	6
47	PXDC1_3	0.0000000000	0.00018564783748412937 / 0.0006324544157642112 / 0.0008799932868837088 / 0.0012100854406902743 / 2.4460595957570077e-05 / 9.238919654315156e-05	1.629093796438785e-09 / 2.354828010860969e-08 / 1.1437120990282457e-06 / 2.506826726053496e-07 / 1.4404482300034928e-05 / 1.341496646230468e-07	0.000504	6
48	HOXD8_1	0.0000011390	1.384655004104117e-06 / 2.098169823270148e-06 / 0.00013057839781136293 / 0.0006273187563236247 / 0.002391299161389133 / 0.00012418009082273935	4.462177612672371e-06 / 3.7108705034506107e-07 / 2.588422064155111e-06 / 4.951039991487746e-05 / 1.3325001401014987e-05 / 0.00014465241485038646	0.000546	6
49	CREB3_5	0.0000000000	0.00011974638832910611 / 2.8492275991361182e-06 / 0.0002672299360603039 / 0.0015619495448511997 / 0.0006694225755824582 / 0.0007820104355851261	3.367539235619778e-08 / 2.960146168251713e-09 / 3.5507108068252503e-07 / 1.15634806074712e-07 / 9.547786692388759e-08 / 9.283068268133278e-07	0.000567	6
50	HDAC2_5	0.0000000000	0.0024571245521046946 / 0.00027132067925628834 / 9.682089638458799e-05 / 0.0005745209404259057 / 0.0011143521019561335 / 8.813885171995659e-06	5.2270805905618696e-06 / 5.052158985938859e-07 / 2.8819687490380823e-06 / 2.0125230234433194e-05 / 2.0453412309359413e-06 / 2.7524824404052385e-05	0.000754	6
51	TIMP1_5	0.0000000010	0.0007131856153707479 / 0.004395200198238863 / 0.0007246067046570448 / 0.0004898581392129352 / 0.0005314272666539294 / 0.0011397228331407	5.172684196778569e-07 / 2.311501161730639e-05 / 3.21307883800088e-06 / 6.009010264662183e-07 / 8.327439275864646e-05 / 1.1941646912994778e-05	0.001332	6
52	COQ10B_2	0.0000000036	0.00028381156148520563 / 0.0011945192630844516 / 9.355412559125023e-05 / 0.00011447010352733596 / 0.004266156536665072 / 0.006336011637689165	9.039504276825803e-09 / 6.006195461219958e-11 / 1.974259905174528e-07 / 1.2053082748861081e-06 / 5.363487408950924e-07 / 6.630188454539638e-06	0.002048	6
53	REEP5_3	0.0000000001	0.0002604645915174344 / 1.6662214108439007e-05 / 0.0014440576489070092 / 0.007046402501490371 / 0.0001422863963685906 / 0.003637547802268041	1.5498910474749387e-08 / 1.5248778277061658e-07 / 4.842659456067433e-07 / 1.1491084964019146e-05 / 9.94537200846768e-06 / 1.9463332862931604e-06	0.002091	6
54	FAM111A_5	0.0000000000	4.4898969618553406e-05 / 2.4668455632971913e-06 / 0.008396935784803085 / 2.1285938805234283e-05 / 0.00017201334171284462 / 0.00396513630435739	2.8379627983912504e-07 / 5.011442931035688e-06 / 2.7338260851547263e-06 / 8.36960570585275e-07 / 0.0001410578503689771 / 0.00014811827476060585	0.0021	6
55	XPO5_2	0.0000000001	0.0001209623595819047 / 0.000188340547489593 / 0.0018652619870494437 / 0.00021645065939681314 / 0.003380556290063177 / 0.008610130886641778	3.868080212014016e-11 / 9.213293248318617e-08 / 1.7999848646465621e-06 / 2.4843669693960186e-06 / 4.8157427373392145e-06 / 1.6123249086459064e-06	0.002397	6
56	MICALL2_2	0.0000000015	0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.00038134035343875063 / 0.012364148039779468	7.498455684868167e-10 / 1.4582924103607157e-08 / 1.3913032862815633e-07 / 5.643046267928915e-06 / 9.075353821264667e-07 / 6.490175971759533e-07	0.00274	6
57	ITGA3_1	0.0000000030	0.005770181686062503 / 1.2412020538304333e-05 / 0.0014786332863597391 / 0.0025299472548494955 / 0.006820424547488444 / 0.0005531418384342248	5.922775528802422e-07 / 4.6735775256735116e-07 / 1.1163600156129396e-05 / 1.4439518922300546e-05 / 2.1428615198188343e-05 / 0.0004769133582838131	0.002861	6
58	MATR3_5	0.0000000205	0.011926215274063212 / 0.0009331303043566046 / 0.0010276150171031416 / 0.00182336903581431 / 0.0003580914875982602 / 0.0015078412320002777	4.924418504897322e-07 / 1.370559303361593e-06 / 1.6001662179812555e-07 / 1.1659751397403969e-06 / 3.3107751763197302e-06 / 0.00023808544096258719	0.002929	6
59	SAT1_1	0.0000002126	0.00037839447623271325 / 0.00010681753824403367 / 0.001443320215490813 / 0.00028286232014178015 / 0.00042879723237597764 / 0.01649068093735444	2.471908559304084e-08 / 1.0167276826134301e-07 / 4.27349479221232e-08 / 1.9148903772583427e-06 / 5.811635331171456e-06 / 2.062293334552713e-06	0.003188	6
60	TMED9_2	0.0000000049	0.004580742781866771 / 0.00013157696997892983 / 0.004688381529867688 / 0.009588847065017484 / 0.002359920632447335 / 2.045294378465323e-05	2.311738097680596e-07 / 3.385203606751943e-07 / 1.428134704742174e-06 / 2.2508154783841546e-06 / 8.005735739477652e-07 / 5.167281077719583e-06	0.003562	6
61	KIF26A_2	0.0000000001	1.5469524150486244e-06 / 8.296463018176517e-06 / 0.006895380226562706 / 0.012900561921483814 / 0.0032271260560706324 / 0.00021924462904813837	1.5344327905473364e-07 / 2.061988698426251e-05 / 8.65696212540371e-05 / 0.00020969562979674127 / 2.9068598486233544e-05 / 7.962530247357052e-05	0.003875	6
62	C19orf66_2	0.0000000010	0.00034498616340953534 / 0.011682032301995177 / 0.00022585824160449916 / 0.0007089738037200934 / 0.002717071783164195 / 0.0083826665816656	1.6212467312990448e-07 / 8.055304607431e-07 / 2.1285718913705297e-05 / 6.7336653328809105e-06 / 9.184791210195023e-06 / 5.963654428661317e-05	0.00401	6
63	GTF3C2_2	0.0000000532	1.1143488565728274e-05 / 6.351892014238265e-06 / 0.00014033845457246834 / 0.0056660681635887335 / 0.018064176445119352 / 0.001679572583230773	5.3778331923390924e-09 / 3.451157087485289e-08 / 1.036058010685455e-05 / 6.86847495002417e-07 / 2.1756858153773495e-05 / 1.4832082275306326e-07	0.004261	6
64	ADAM9_5	0.0000000000	9.192181643816992e-05 / 0.01456393928510654 / 0.0024406101382475976 / 0.0003651548756090639 / 0.002859171921278692 / 0.005910547863522942	1.2444797620355103e-06 / 0.0006441060918252728 / 6.0935458892623245e-06 / 2.470519395812343e-05 / 6.138314516641965e-06 / 0.00047208959650121314	0.004372	6
65	KDM1A_3	0.0000000105	0.00020172074167490282 / 6.059446073630997e-06 / 3.4966947244211546e-05 / 0.00035787841907612255 / 8.084536486163457e-05 / 0.030001525763098943	1.9191726349291212e-07 / 1.1031846529359998e-09 / 1.1293378746596968e-07 / 3.850331218970383e-06 / 3.0967264542843456e-07 / 4.878540657681566e-06	0.005114	6
66	SRSF1_1	0.0000149516	0.003065043011644369 / 0.00022847309395920425 / 0.007223252257555813 / 0.002399019537670231 / 0.0023157697041580965 / 0.016498427519842422	1.756253200088118e-08 / 1.4552116534728694e-07 / 1.9822115797618054e-07 / 0.00022932374573720484 / 8.206690733883024e-07 / 2.2543227834379112e-07	0.005288	6
67	WHAMM_1	0.0000006802	0.00173044075017522 / 3.679473658399758e-05 / 0.007154235078360664 / 0.0005658979552839525 / 0.022166841169996183 / 0.0008973831238703076	1.819882893948959e-08 / 7.796445160214981e-06 / 4.241150850168489e-05 / 2.1522400443486433e-05 / 1.3244633411180583e-06 / 3.4248686087626584e-06	0.005425	6
68	LEPRE1_4	0.0000000000	0.0009439710790866046 / 0.0005817669851518343 / 0.001866551132439743 / 0.0064518824694126935 / 0.024010305513094434 / 0.0005799813920946167	5.057896230784973e-09 / 1.2435409883337575e-09 / 4.849591006599988e-07 / 2.513207633152382e-07 / 7.926212421845088e-06 / 9.994009471711418e-06	0.005739	6
69	TRMT61B_1	0.0000029142	0.00019565429421873628 / 9.250262180987785e-07 / 6.358888418896258e-05 / 0.007843131253822322 / 0.026473307528210963 / 0.0005756579425604447	1.5078060373014486e-07 / 2.934542273575563e-07 / 1.2562708953802216e-08 / 5.523864073902343e-05 / 2.1559815321332083e-05 / 3.99120679034904e-07	0.005859	6
70	KANK1_1	0.0000005033	0.00029139375190295606 / 0.009220967328515883 / 0.008770410107355643 / 0.014437131210731376 / 0.002271551295087959 / 0.004557941079021841	5.395125257906878e-09 / 1.5463446946793206e-07 / 9.30211963759247e-07 / 1.5254780926528496e-05 / 2.370997764208311e-05 / 3.6188491330904777e-06	0.006592	6
71	FAM126A_1	0.0000010549	8.712601577854501e-09 / 4.778480179883678e-05 / 0.029987683740818265 / 0.0006110060061203364 / 0.0014562282237067896 / 0.010748894710017389	5.924782315476787e-13 / 7.1855057793508855e-09 / 5.8414503343797016e-08 / 3.0767728402054146e-07 / 3.866278498641532e-05 / 6.044718602493066e-06	0.007142	6
72	CASKIN1_1	0.0000009531	0.0004052971561229435 / 0.004531342266561176 / 0.0026490796375761676 / 0.0030838618137353662 / 0.0016555906467057811 / 0.03955358967054088	6.0724511656641e-08 / 2.4239072038012358e-06 / 2.9932584561794108e-06 / 2.381049500017635e-07 / 3.5273148222341567e-07 / 8.97249895656115e-07	0.008646	6
73	PHIP_3	0.0000000007	0.00021593310745224813 / 0.001021373946566871 / 0.000875589310570064 / 0.03219163721249994 / 0.018101605571703944 / 0.0018008865475031112	7.804787711336222e-10 / 7.962047079615459e-07 / 1.3767715926221406e-06 / 9.21068648623731e-07 / 2.0427438064371946e-06 / 2.061133383896347e-06	0.009035	6
74	ISL1_1	0.0000011109	0.00029139375190295606 / 0.004557941079021841 / 7.763485144629643e-05 / 0.03147989324458417 / 0.009220967328515883 / 0.014437131210731376	1.0776705684350702e-07 / 9.139106854866213e-08 / 1.5262551782073314e-06 / 7.17589463363722e-05 / 1.6643398808959587e-05 / 2.7254012211130744e-05	0.010011	6
75	FAM114A1_1	0.0000011740	0.008158453075892491 / 0.00706078944078839 / 6.392429369799613e-05 / 0.047093499348454915 / 0.0011036487237694873 / 0.0012146763275784356	3.9222069331739446e-09 / 1.0484859600093688e-07 / 1.1328590320930398e-08 / 1.4044847451826967e-07 / 1.6732185403869882e-06 / 2.0603621902808526e-07	0.010782	6
76	BHLHE40_5	0.0000000001	0.0007215354754391255 / 0.0003445000837785309 / 1.9977845432945953e-05 / 0.04162183582083479 / 0.0018003544554504962 / 0.022135056393026143	1.9299792697031883e-08 / 5.991364646156074e-06 / 6.2842442407564126e-06 / 7.23523138723521e-05 / 4.37410397098931e-05 / 8.612084128833267e-05	0.011107	6
77	RNH1_2	0.0000001050	0.000506059688566897 / 0.005186853257558283 / 0.012649170673498711 / 0.001227543851685287 / 0.02830343719752466 / 0.04658173961213423	1.9114165577673726e-07 / 1.1785627242528596e-05 / 1.1961430183679334e-05 / 5.5941363386033185e-06 / 0.0003160168984552755 / 6.436245153753663e-06	0.015742	6
78	SLC35F5_2	0.0000000018	0.0004361351075887015 / 0.022927539814265496 / 0.04092933544326924 / 0.006547044668673556 / 0.028271710657491178 / 0.00020952110146219778	4.764738756551879e-09 / 4.080828723669075e-06 / 3.470949128294469e-05 / 1.4915989057385644e-06 / 3.6434591065850956e-07 / 5.290028218404434e-06	0.016554	6
79	TRAP1_1	0.0000001560	0.0020456136275657888 / 0.002859168680149655 / 0.005851685675009941 / 0.01576374271095223 / 0.026715472976530045 / 0.04871212229027521	3.490113886399775e-11 / 1.4427864532484367e-07 / 6.218256736106799e-06 / 8.405023850544253e-07 / 1.4752725092614505e-05 / 0.000126359581600695	0.016991	6
80	SLC10A3_1	0.0000020963	0.011413935706631708 / 0.017443397981769932 / 0.014660785392642973 / 0.017145541610166553 / 0.03683753470884825 / 0.010610163045225487	5.700211166503259e-07 / 1.392805628701067e-07 / 3.319072411206087e-06 / 4.021260874574252e-06 / 1.6786320992493728e-06 / 6.426344116619477e-06	0.018019	6
81	IL10RB_1	0.0000014439	0.0018473350729729212 / 0.025082579510674555 / 0.015382714940475899 / 0.01903033340546255 / 0.042397669225769964 / 0.010590633670572098	6.305508475517821e-07 / 2.1289852323575975e-06 / 1.3929853301059418e-05 / 5.9674182467591734e-05 / 0.0005196865649666491 / 8.689281900910874e-05	0.019055	6
82	CCDC138_3	0.0000000000	2.8507575756692187e-05 / 8.39983457440053e-08 / 5.171191093952371e-06 / 0.00013241015291548088 / 0.00013231289428074683	3.594844984072266e-08 / 4.1699450769671714e-10 / 1.7829184957785041e-06 / 1.6716512185751531e-07 / 6.673606916636778e-06	5.97E-05	5
83	LDLRAP1_1	0.0000008179	0.00011095297992729127 / 5.264359468000088e-05 / 0.0011242387519002353 / 4.668223816223458e-05 / 1.2920956774321015e-06	7.024419920758419e-08 / 3.7947570137300835e-07 / 1.3563326532912054e-07 / 8.17408329321785e-05 / 8.828337775002166e-05	0.000267	5
84	SH3BGRL3_3	0.0000000001	4.2473135511991315e-05 / 0.00018110968427817472 / 2.3012675922598175e-05 / 0.0012229341595829208 / 7.876891018158643e-05	6.991877310539878e-06 / 9.480200177754412e-06 / 0.00015579668074547338 / 1.8811555342370173e-05 / 6.910060016993254e-06	0.00031	5
85	RARRES3_3	0.0000000000	5.445858436353469e-05 / 0.0009962374983153238 / 0.00039011483425120365 / 0.00012136000976514409 / 3.791878524439541e-05	1.56194833594799e-09 / 1.296245999203945e-06 / 1.1756173797034747e-06 / 1.527843952821709e-05 / 5.848148683004699e-07	0.00032	5
86	ANXA4_4	0.0000000000	1.363288691355937e-06 / 1.5143046244596162e-05 / 5.189840282140393e-05 / 5.782599824929034e-05 / 0.001524236220832947	1.0031685363992852e-08 / 6.841456697948725e-09 / 1.9180526546377784e-06 / 8.794172382219916e-06 / 2.953468988272718e-06	0.00033	5
87	LYST_1	0.0000027714	0.0014431024451110606 / 5.264359468000088e-05 / 0.00011095297992729127 / 0.00020173841888508878 / 6.995348463708383e-05	1.1240472731245707e-08 / 2.350080008352624e-06 / 1.1075551169706485e-06 / 1.7042664405713885e-06 / 4.2116046384684526e-05	0.000376	5
88	MR1_4	0.0000000000	7.715095979792449e-07 / 0.001693666645875025 / 6.395023692800854e-05 / 0.00031256159798863684 / 3.9188876899229826e-06	1.1557582761220409e-08 / 5.677180579700876e-06 / 2.8754646285556484e-06 / 5.64979021764616e-07 / 1.8797358227572578e-05	0.000415	5
89	SELRC1_1	0.0000005524	0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.0004410378323337517 / 0.00010681753824403367	1.2864802377615588e-11 / 2.1196501777135548e-08 / 1.3367474421932726e-09 / 7.5658631683473564e-06 / 5.602327158926525e-08	0.00056	5
90	LDHB_5	0.0000000000	2.9413591946334052e-06 / 0.00018071660821354673 / 1.726070100137361e-05 / 0.0006331647449173639 / 0.0029940534519961185	2.3674403554451728e-09 / 1.5213269839159292e-06 / 4.075392395353731e-07 / 1.8533263086532664e-06 / 6.582873587671421e-05	0.000766	5
91	GBE1_2	0.0000000003	0.0033273695719493366 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.0003451393798156882 / 0.00038134035343875063	5.906459505383357e-08 / 2.4094693488118412e-09 / 1.0620489017054289e-07 / 6.750639833651121e-07 / 1.8752484455808676e-05	0.000815	5
92	PTRF_2	0.0000000003	0.0033273695719493366 / 2.1541055929197527e-08 / 0.0003451393798156882 / 1.9308695609987287e-05 / 0.00038134035343875063	4.017261878814523e-08 / 7.146428295045248e-09 / 6.101976957550238e-07 / 2.1688184575439267e-06 / 6.686443921029525e-06	0.000815	5
93	SQSTM1_3	0.0000000000	3.9761649107081705e-05 / 0.0016006026930324019 / 0.0008611052684263142 / 0.0012009850065108874 / 0.0006237640708459632	4.01947151989452e-07 / 1.339226375307952e-06 / 1.754090841474079e-06 / 7.055430531026282e-07 / 2.6767693410519625e-06	0.000865	5
94	PA2G4_1	0.0000000017	0.001443320215490813 / 0.00037839447623271325 / 0.00042879723237597764 / 0.003993715376548959 / 0.00028286232014178015	3.045245115555592e-10 / 1.8399976601880802e-08 / 5.830030485334704e-07 / 9.508100999171547e-06 / 1.13769352855429e-05	0.001305	5
95	GBP3_2	0.0000000003	0.0005839379621670203 / 1.3428726435262393e-05 / 0.005991852836482861 / 0.0001081781120537704 / 2.8744610334651343e-06	4.819954330621288e-08 / 6.412523041836917e-07 / 2.8569657952677404e-06 / 2.0985004888144685e-05 / 2.3525509311119436e-06	0.00134	5
96	CHD7_2	0.0000000001	0.0018350968591216627 / 7.477363698097769e-05 / 0.00015975427450238799 / 0.00391277170211791 / 0.0008685464813169234	1.0531573829941702e-07 / 7.878415280920932e-08 / 1.1141611641319887e-07 / 5.1757956178869716e-06 / 8.934190321293886e-06	0.00137	5
97	ELF4_4	0.0000000000	1.5042859087051511e-05 / 0.0015054443180049152 / 0.0035324162802343384 / 0.0015681053781698034 / 0.00044306616234558656	1.0129117193066866e-07 / 3.803422404924242e-08 / 3.196969576173562e-05 / 2.0994506448972058e-06 / 8.674339153748824e-06	0.001413	5
98	HEXB_2	0.0000000027	0.0001364689621921479 / 0.0017139782149577006 / 0.00042251637580553855 / 0.004506824346577342 / 0.0011693468213267385	5.600402893224147e-07 / 1.7114753018966675e-06 / 7.859127616630422e-06 / 2.136847848300081e-06 / 1.057919545610576e-06	0.00159	5
99	TGOLN2_3	0.0000000000	0.002887936541355392 / 0.0012489133459296009 / 3.971802768150102e-09 / 5.351370414635355e-06 / 0.004542992850202789	1.5278667902264538e-08 / 6.147579495364705e-07 / 2.55317658003628e-07 / 9.866879372887889e-08 / 6.124699763744859e-06	0.001737	5
100	CBR3_5	0.0000000000	1.7429615872247697e-06 / 2.1772701241259695e-05 / 4.265116466854638e-05 / 0.0006691661140725223 / 0.009174735989250154	1.7321244665799745e-08 / 1.9865066542844766e-06 / 6.139861852092745e-07 / 3.5205839483278234e-06 / 4.046680434424515e-05	0.001982	5
101	C14orf93_1	0.0000000417	0.005409509534570436 / 0.0014863302195178008 / 0.002391299161389133 / 0.0006273187563236247 / 1.384655004104117e-06	7.500915749450172e-10 / 3.167346841801568e-06 / 6.173059623938025e-07 / 7.496583765477882e-06 / 2.018269137344719e-06	0.001983	5
102	ACVR1B_5	0.0000000000	0.0011897273750790794 / 4.043863569216427e-06 / 0.003135726107000613 / 1.2302005748125012e-06 / 0.005979891210353361	8.795727468366677e-07 / 1.740359378085258e-08 / 3.922859794878605e-06 / 5.715287595383605e-07 / 3.0426357547305182e-05	0.002062	5
103	WNK2_1	0.0000008965	0.004531342266561176 / 0.0004052971561229435 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662	5.735186182795572e-07 / 4.097215580173646e-09 / 2.1966688549867895e-05 / 7.38514634627583e-06 / 9.495710202696889e-06	0.002465	5
104	GBE1_5	0.0000000000	3.826852437313171e-06 / 0.0010708658291423757 / 0.00019953068534511048 / 0.009169711616283972 / 0.0026316110463780696	9.044891469948086e-09 / 3.7048735780400227e-07 / 2.359441941877069e-06 / 1.5764817932193767e-05 / 2.274686348690355e-05	0.002615	5
105	RAB27A_2	0.0000000000	7.635253341668868e-05 / 0.005021656852415849 / 3.5215907075366917e-06 / 0.00034267788827357215 / 0.007895113233237851	1.914896020510999e-07 / 9.517291296985127e-08 / 7.969576900636687e-08 / 5.846288233066031e-08 / 4.5361993939378207e-07	0.002668	5
106	FAP_3	0.0000000006	0.0019684942173753836 / 0.0009928703588443979 / 0.0005051149609558843 / 0.00011232928113623314 / 0.012918030852908461	1.2766883170125572e-07 / 2.4021041707717316e-06 / 1.0836840144491595e-06 / 8.446479999419288e-06 / 3.6833375749558764e-06	0.003299	5
107	THBS1_1	0.0000000712	0.0019027179320774803 / 0.004613449756294485 / 0.0003168019030192227 / 0.0012733956455115425 / 0.010654255097368902	2.1096989696063183e-09 / 2.8418823932552776e-08 / 2.9577603926263325e-08 / 1.6345742810026593e-05 / 7.1941049967859985e-06	0.003752	5
108	RNF44_2	0.0000000001	0.0007973635551597535 / 7.563774009011881e-05 / 0.01008336409450162 / 0.004045539400699223 / 0.004865413756574913	5.271414210724663e-11 / 3.736942531550046e-07 / 2.3747819656119838e-08 / 1.893540361128054e-06 / 1.2212684566221971e-06	0.003973	5
109	C2orf44_4	0.0000000014	1.0808929306666273e-05 / 0.008934208121620274 / 0.00010039306136116464 / 0.009784265308543377 / 0.0024009587334497774	1.2187744602716387e-10 / 1.9588399373708684e-06 / 4.6145010226590306e-07 / 3.855402108931244e-05 / 2.3663313142656787e-05	0.004246	5
110	ZSCAN2_1	0.0000003244	0.005494404451518434 / 0.002117501407135496 / 0.015063580358728427 / 0.00406276527468287 / 0.00029389877591584477	4.440150276665828e-06 / 1.6041254678652375e-05 / 6.101223267687242e-06 / 1.4917171986665666e-06 / 1.8918665259353665e-05	0.005406	5
111	PSMB8_3	0.0000000001	1.1139371348435439e-05 / 0.000295206951604009 / 0.0011420234721703612 / 0.004002189263586216 / 0.022007285373854	3.18097586113718e-08 / 8.739864511743991e-07 / 1.4187996767508308e-05 / 1.4206186275488269e-05 / 2.1536287095072426e-06	0.005492	5
112	CTGF_2	0.0000000009	0.00015265799477510392 / 0.004284835035004821 / 0.005655033062620194 / 0.017812704981803436 / 0.00018190158542752172	5.263266054115357e-07 / 4.3695038068811766e-08 / 3.7740283990797325e-06 / 7.135038004681359e-07 / 2.643168822853883e-05	0.005617	5
113	DAP_1	0.0000000596	0.008158453075892491 / 6.392429369799613e-05 / 0.01165101001080378 / 0.00706078944078839 / 0.0012146763275784356	1.4736850125189888e-07 / 3.908902039015359e-08 / 1.7628401584823726e-07 / 1.5347002454072624e-05 / 1.7507947709175734e-05	0.00563	5
114	PHOX2A_1	0.0000003175	0.008158453075892491 / 6.392429369799613e-05 / 0.00706078944078839 / 0.01165101001080378 / 0.0012146763275784356	5.8181933193632506e-08 / 1.1078332486685944e-07 / 1.2847626080278513e-05 / 1.9169572452878826e-06 / 1.3210118079992226e-05	0.00563	5
115	MVP_2	0.0000000015	0.0003074328712443293 / 0.029215443986862575 / 9.407443780393908e-05 / 0.0007597570913260385 / 4.843098209783887e-05	4.002114425736759e-08 / 1.6803136761019638e-06 / 3.376253203984945e-08 / 1.008528085216226e-05 / 4.819827094154422e-06	0.006085	5
116	CCNJ_2	0.0000000010	0.005156889617706872 / 0.0037116981070019926 / 0.018339330602739977 / 0.0005410238034488199 / 0.0029241900112892644	1.3384145050432693e-05 / 1.2259034650488922e-06 / 2.418247349561274e-06 / 5.022621230368505e-05 / 3.457954174876677e-05	0.006135	5
117	MAP4_5	0.0000000001	0.0005031786684884779 / 0.010922608465190551 / 0.018146216162979706 / 0.0003254856473440077 / 0.001272088116869848	2.587716794178391e-07 / 3.798173592497599e-08 / 2.5392647842825153e-06 / 4.942693897536645e-07 / 9.527740137246758e-08	0.006234	5
118	ATP5B_2	0.0000000014	1.0473941865935008e-05 / 0.00047787043862318663 / 0.02960215538361295 / 0.001031466405675943 / 0.00013666281877242411	7.117260294468996e-09 / 6.152782689367921e-07 / 1.526236991383182e-05 / 1.8976244710357432e-05 / 2.5507040748716144e-06	0.006252	5
119	TRAM2_3	0.0000000000	7.050716055970537e-06 / 0.0001057656674813077 / 0.0025449721290128477 / 6.997404830789269e-07 / 0.03280415443708167	5.729353647005044e-08 / 1.910962326072629e-07 / 8.344215866087099e-06 / 4.014110177183549e-06 / 1.7722857190857362e-05	0.007093	5
120	CCDC107_5	0.0000000004	7.799742935751802e-05 / 0.023152072094571645 / 0.014505125297696268 / 0.00010031692846422633 / 0.00039456234783499816	2.5979973718838742e-08 / 5.275125038891406e-07 / 1.2574262998000307e-06 / 4.826438486358518e-06 / 3.332582738649872e-06	0.007646	5
121	SMARCAD1_5	0.0000000000	6.51572554597248e-05 / 1.121807735413933e-05 / 0.0009794106383235514 / 0.028651749233987035 / 0.016373864330489554	4.951274541156556e-07 / 4.932698411729371e-06 / 3.7416170837321407e-06 / 2.232387301624823e-06 / 6.909674555415473e-07	0.009216	5
122	HRH1_1	0.0000009062	0.007112363650923645 / 0.007730255820425719 / 0.02421022399736038 / 0.001383098528892269 / 0.006385380233425884	8.024725118266073e-09 / 1.3814036761412276e-07 / 2.07690167148044e-06 / 1.4044796518330034e-05 / 1.4197658969421668e-05	0.009364	5
123	KHDRBS1_2	0.0000000015	1.6169392314406466e-05 / 0.0039056626487888758 / 0.0034273259551571168 / 0.03391386466641536 / 0.011666948417914267	9.514267607742899e-13 / 2.8566604252327994e-07 / 7.517707711246514e-07 / 4.1751581964055053e-07 / 9.055789447982931e-07	0.010586	5
124	E2F6_3	0.0000002841	0.0022254132117215356 / 0.0037188790361072878 / 0.005458005465302464 / 0.0014398907128301208 / 0.04086571019880003	4.421453475946776e-08 / 1.5392585786553033e-06 / 0.0003430693964816855 / 1.779882292403961e-06 / 0.0002956989113369879	0.010742	5
125	ELL2_2	0.0000000202	0.00011694820055399171 / 0.029386513254453968 / 0.005657975920541809 / 0.028459156083205858 / 0.01406740315871594	8.347517785439741e-08 / 1.2698717079911781e-06 / 1.917338652438103e-05 / 0.0001196727478086908 / 2.0681105855800244e-05	0.015538	5
126	BSN_2	0.0000022389	0.000506059688566897 / 0.04616500613759174 / 0.012649170673498711 / 0.005186853257558283 / 0.02830343719752466	5.0173732858781275e-06 / 1.1005994245083331e-07 / 0.00024710770557642556 / 0.00048732984216352446 / 0.00023929723037045147	0.018562	5
127	ATG4A_5	0.0000000000	4.475035366083391e-06 / 9.946560976238241e-06 / 1.150460981566587e-06 / 6.699525372343991e-05	2.070885361738112e-08 / 3.791151058200872e-07 / 2.8872435045296478e-08 / 0.00012711434042399471	2.06E-05	4
128	CD44_4	0.0000000000	4.4784520790283526e-08 / 2.3008815242152554e-05 / 5.2052109653188956e-05 / 0.00014533006515361492	7.884191479096678e-08 / 2.9710643899587148e-06 / 1.5781437020851443e-06 / 6.210975626614534e-07	5.51E-05	4
129	GSN_5	0.0000000000	3.785922406236843e-10 / 3.0058719101012673e-05 / 0.00029646205587575313 / 6.646730266541163e-05	8.816984894077637e-10 / 2.2588865060721033e-06 / 7.88507208198445e-05 / 4.284376587003957e-05	9.82E-05	4
130	CD99_5	0.0000000000	2.0149183113126577e-05 / 0.0006745061120899554 / 0.0002998852328395526 / 0.0001242923271196099	3.1338403532472386e-09 / 0.0006507487844929586 / 5.172267401380639e-06 / 9.968659271858592e-06	0.00028	4
131	GNAI2_5	0.0000000000	0.0005584151279765244 / 0.0003249499378752368 / 4.745051251091654e-05 / 0.00030759784724731154	4.982873808104418e-08 / 9.650800047119655e-07 / 2.454295952727384e-07 / 9.904904324446315e-05	0.00031	4
132	DDX60_5	0.0000000000	2.9212913515461393e-06 / 0.0001530409063220267 / 0.0003993610031162385 / 0.0010695426477561165	7.01839699594606e-08 / 2.0329686030779097e-06 / 1.4613415440657328e-05 / 1.702607599935211e-05	0.000406	4
133	MICALL2_3	0.0000000000	4.697595022472674e-06 / 6.457501817223296e-05 / 0.0015363886875154054 / 0.00014385763146450997	1.7875525723925519e-06 / 1.642694121565277e-07 / 1.8052618402003836e-05 / 5.8265193908577595e-05	0.000437	4
134	SOAT1_5	0.0000000000	0.001922385896174513 / 1.924383271682602e-06 / 2.782774586423633e-06 / 3.555527535100237e-05	7.936734231102217e-07 / 6.625132467195288e-08 / 5.379303522414254e-07 / 2.3383986457320025e-06	0.000491	4
135	PLEC_1	0.0000008789	4.778480179883678e-05 / 0.0006110060061203364 / 8.712601577854501e-09 / 0.0014562282237067896	2.8277390114780423e-07 / 2.166203983124237e-06 / 1.5583735231329512e-07 / 2.7125361005219603e-06	0.000529	4
136	XRCC5_1	0.0000000924	1.384655004104117e-06 / 0.0006273187563236247 / 2.098169823270148e-06 / 0.0014863302195178008	2.6130050369275158e-06 / 2.132206160555519e-05 / 2.4237849248550327e-06 / 0.00030699349223093454	0.000529	4
137	OSGEPL1_1	0.0000001116	0.00028286232014178015 / 0.00037839447623271325 / 0.001443320215490813 / 0.00010681753824403367	3.604572142413008e-06 / 4.082064229081972e-06 / 3.18593215315723e-06 / 9.670676646757636e-07	0.000553	4
138	TMEM97_4	0.0000000000	0.00018650020835883543 / 0.0004347886633272347 / 4.502684569031259e-06 / 0.0016700457783649062	3.3084881992489725e-06 / 4.754536166762309e-06 / 1.3093900089996567e-06 / 5.225302868715506e-05	0.000574	4
139	GLIS3_4	0.0000000000	0.0002286645360176498 / 0.0006619438558324503 / 0.0016620049728346326 / 1.1074671736457553e-05	1.510316419391924e-06 / 3.2409409252278102e-06 / 9.224875739627753e-05 / 1.930014755272634e-05	0.000641	4
140	ANXA1_5	0.0000000000	5.8551591866382045e-05 / 3.45022524746413e-05 / 6.004993403577111e-08 / 0.002751213558972749	2.397154304313467e-07 / 3.176106815413732e-06 / 6.107114335334353e-07 / 1.2210016577494943e-05	0.000711	4
141	FAM120A_5	0.0000000001	0.0026813412993839337 / 0.0005742956528301279 / 3.563997625540032e-05 / 8.528922868820983e-06	0.0001881828357253321 / 0.00012537124618201126 / 1.3817216627076195e-05 / 0.00011563779547673361	0.000825	4
142	SAFB_3	0.0000000001	0.001211277784043611 / 0.00011818878635236698 / 0.00029246473195964197 / 0.001769841813108865	7.668444452032125e-07 / 2.898461734945786e-07 / 2.8130419096127126e-05 / 0.00035040496082839104	0.000848	4
143	ACTN4_4	0.0000000000	1.4106395746220967e-05 / 8.221349715218104e-05 / 0.003449453406084509 / 0.0001267717634392765	3.3938237122738275e-07 / 1.2062404978268685e-06 / 4.0239968184075355e-06 / 2.990385220556594e-05	0.000918	4
144	FAM117B_5	0.0000000000	0.00014565693019513351 / 0.0006387724048262495 / 2.041989162397474e-07 / 0.00308065083431233	1.2462660948443544e-05 / 4.0378352806812125e-06 / 4.5557593081500904e-08 / 6.255861262356289e-05	0.000966	4
145	TSSC1_1	0.0000008042	0.0010281262291342236 / 0.0008973831238703076 / 0.0014311836039126026 / 0.0005658979552839525	4.773040777006663e-07 / 1.293648273273451e-06 / 1.370737279606987e-06 / 6.872239294614834e-08	0.000981	4
146	SERPINE2_1	0.0000006237	8.712601577854501e-09 / 0.003917317274808632 / 4.778480179883678e-05 / 0.0006110060061203364	4.293656906359287e-09 / 7.59699887090359e-07 / 2.4805326670497096e-06 / 2.6318189672753774e-06	0.001144	4
147	IFNAR1_5	0.0000000000	1.6950082284852724e-05 / 0.00023259440421303834 / 2.145061357704084e-05 / 0.006168307042686711	2.6777259205549025e-06 / 3.126328063081149e-07 / 1.6378968792487728e-05 / 1.980502151445686e-05	0.00161	4
148	UEVLD_3	0.0000000002	0.0025817513756711884 / 0.0002058200859707558 / 0.0001532402705811572 / 0.003951386408683102	1.7719417389393089e-06 / 1.5327037128336517e-08 / 5.132415043139141e-08 / 8.649188479247404e-07	0.001723	4
149	GUF1_5	0.0000000000	5.893107805476978e-05 / 0.007964457709027949 / 4.303196745477378e-05 / 2.6967345038980607e-05	3.970170459579241e-07 / 2.864249504984967e-06 / 3.435012765675232e-07 / 1.5389318932784949e-06	0.002023	4
150	GBP3_1	0.0000015823	0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425	1.8104358020946005e-07 / 2.2473742888087726e-07 / 3.977899627306711e-05 / 5.118490443586335e-06	0.002027	4
151	MED28_1	0.0000032077	0.0003168019030192227 / 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425	2.9684923703899697e-07 / 6.654843522911474e-07 / 3.1176140675136144e-06 / 3.225376490885068e-06	0.002027	4
152	SLC2A10_1	0.0000000972	0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425	1.7631746614895863e-07 / 2.4782620652363583e-09 / 6.763392837610305e-07 / 2.321466389902454e-06	0.002027	4
153	CBR3_1	0.0000000238	0.0003168019030192227 / 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485	7.910872738545078e-09 / 1.4202365174097019e-08 / 5.43796956141398e-07 / 4.674686520121403e-05	0.002027	4
154	HIC2_1	0.0000007789	0.0019027179320774803 / 0.0012733956455115425 / 0.004613449756294485 / 0.0003168019030192227	3.0633550655698566e-10 / 2.1696779182322382e-09 / 2.2828231685954628e-07 / 2.4650085263362296e-06	0.002027	4
155	IGSF9_1	0.0000004185	0.0012733956455115425 / 0.0003168019030192227 / 0.004613449756294485 / 0.0019027179320774803	3.3765982883653153e-06 / 2.559009185958782e-07 / 1.2961469049521693e-06 / 8.135407791689286e-05	0.002027	4
156	RCAN1_1	0.0000010839	0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 / 0.0003168019030192227	3.52499926166527e-09 / 1.4195702150916024e-07 / 2.8012155247278448e-06 / 8.591081719368746e-08	0.002027	4
157	SAFB_1	0.0000022906	0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 / 0.0012733956455115425	1.2527049345521191e-06 / 1.2341574556015853e-07 / 4.073201704051311e-08 / 5.976596803731563e-06	0.002027	4
158	HNRNPA0_2	0.0000000370	0.0009389452362024158 / 0.0004583304262309702 / 2.0318525623421967e-06 / 0.006886174737452949	6.591983136046331e-08 / 2.1078089903628105e-05 / 2.1991513327880328e-05 / 6.211957230218145e-05	0.002071	4
159	ISL1_1	0.0000000008	0.0014562282237067896 / 8.712601577854501e-09 / 4.778480179883678e-05 / 0.008799197542964286	4.47926130890511e-10 / 1.3159792563051542e-10 / 1.6267903098803325e-06 / 8.859331058014511e-06	0.002576	4
160	PPIC_1	0.0000008150	1.1499890891595663e-06 / 0.0023486428669150803 / 0.004509729888699788 / 0.003649857824379229	6.181851966897516e-08 / 4.336126091570401e-07 / 1.130291682742051e-06 / 5.702819528263402e-06	0.002627	4
161	CBX1_1	0.0000073072	0.00920357999307954 / 0.00020520490391129044 / 0.0014863302195178008 / 2.098169823270148e-06	3.4308469313672e-05 / 0.00016072496067379242 / 0.000416531131321131 / 1.1909250396666738e-05	0.002724	4
162	ARID3B_1	0.0000039314	0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 / 0.0034947768260440494	5.689363226662423e-09 / 3.5223565854980375e-06 / 2.7692513603614087e-06 / 7.767239795505205e-06	0.002821	4
163	RNF157_1	0.0000017210	0.004531342266561176 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662	1.0799957008656176e-05 / 7.097149358472166e-05 / 4.819541314832769e-07 / 7.676415694714317e-07	0.00298	4
164	EIF3L_2	0.0000000102	0.005135657485519335 / 0.005326745976664332 / 0.0017435819308224765 / 7.384136449790188e-06	1.8190521073639574e-10 / 1.0527503241568249e-06 / 4.518548487460203e-06 / 1.3638553131166296e-06	0.003053	4
165	SLC25A43_2	0.0000000002	0.00014847770954858836 / 0.0010357469368733494 / 0.0010144217502109298 / 0.010259629272911746	3.357035874085631e-07 / 7.382332140811268e-07 / 2.131827740313582e-06 / 3.004944425021926e-05	0.003115	4
166	OLFML2A_1	0.0000000021	0.0014562282237067896 / 8.712601577854501e-09 / 0.0006110060061203364 / 0.010748894710017389	1.2437444351849456e-10 / 1.877118300185312e-10 / 1.270455283512457e-06 / 1.2117974236888312e-06	0.003204	4
167	HNRNPA1L2_4	0.0000000000	3.055750323559003e-05 / 0.013700253988565498 / 3.881898534012908e-05 / 4.532481843678641e-08	9.763383363669304e-09 / 6.413557230739407e-06 / 1.1996173334605904e-08 / 2.6326526346171393e-08	0.003442	4
168	GPR125_1	0.0000015939	0.0004338260851758113 / 0.005078710464709388 / 0.005770181686062503 / 0.0025299472548494955	8.375396341394661e-06 / 1.2620826876929007e-07 / 5.037605201133463e-06 / 4.397437068329601e-06	0.003453	4
169	HFM1_5	0.0000000000	4.6027629362357145e-06 / 2.054289713438471e-06 / 0.010747113861164049 / 0.0030735298911349954	5.2804634950801046e-08 / 1.3823733955490087e-07 / 0.0002289318652341564 / 0.00017922188693161184	0.003457	4
170	FAM161A_3	0.0000000004	1.1900765556084342e-06 / 6.104336159313168e-05 / 0.0038692378656813085 / 0.010450418229319037	7.836775108119704e-06 / 4.602994442160525e-06 / 0.0014084623238924201 / 0.006437120167388166	0.003595	4
171	MYO1E_5	0.0000000000	9.1301369378943e-07 / 3.6970513366191076e-05 / 0.014560624799721568 / 0.00044473645621912025	1.563633164899415e-07 / 6.6703997984050774e-06 / 0.0002544952895081012 / 1.2369712374983664e-06	0.003761	4
172	BHLHE40_2	0.0000000008	0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 0.012364148039779468	3.6750231825447993e-09 / 1.3797224307526888e-10 / 4.5238117998428525e-10 / 1.4503164618207844e-05	0.004009	4
173	IPO9_1	0.0000001864	0.00706078944078839 / 6.392429369799613e-05 / 0.0011036487237694873 / 0.008158453075892491	7.925030915673659e-07 / 2.436316843178784e-07 / 2.7933385967164893e-06 / 3.7162081746516914e-06	0.004097	4
174	MALT1_5	0.0000000000	8.286399528571891e-06 / 0.0002461865995006486 / 0.00023833137981344143 / 0.016843325771737905	3.375997586023991e-08 / 1.2071446047409586e-07 / 1.095602481975961e-06 / 2.6082135535498982e-06	0.004334	4
175	GDPD1_1	0.0000033642	0.008597087236259153 / 0.002859168680149655 / 0.0007069744136606002 / 0.005851685675009941	9.233213274811235e-08 / 3.5536116052273754e-07 / 2.1037456632604637e-07 / 1.3670539309103289e-05	0.004504	4
176	CLIC1_5	0.0000000000	0.00048798421080350877 / 0.003091093830161087 / 0.005843494432330533 / 0.008851783624153233	3.133239901460721e-08 / 1.3305262196278536e-08 / 4.3396495831301414e-05 / 1.8259140204877226e-06	0.004569	4
177	GBP1_1	0.0000000190	0.00029139375190295606 / 0.008770410107355643 / 0.009220967328515883 / 7.763485144629643e-05	2.034005959874992e-08 / 1.025777265986079e-05 / 3.7717113262051256e-06 / 6.322665753334008e-05	0.00459	4
178	WDR1_4	0.0000000063	0.00018307154229595032 / 0.0002457066480750095 / 0.0005563718559501817 / 0.01757082718712336	1.4158768736111935e-07 / 1.8926145330443176e-07 / 3.145940065328651e-05 / 2.00918389447038e-06	0.004639	4
179	NOLC1_1	0.0000002124	0.005497026258977277 / 0.0037411319458859455 / 0.001569082671062799 / 0.009893561180811163	1.0104488773237543e-08 / 7.714332997539589e-07 / 2.1884817904926247e-06 / 3.370149988961001e-05	0.005175	4
180	SUCLG2_1	0.0000002256	0.0008973831238703076 / 0.0060047412034100744 / 0.013949817553702996 / 3.679473658399758e-05	4.6445581997855444e-07 / 0.00013589105082118295 / 6.517922811200161e-07 / 3.2332580875235436e-06	0.005222	4
181	TMEM50B_4	0.0000000000	0.00021033920160836247 / 3.048709751971941e-06 / 7.4963019248993875e-06 / 0.02190343894897618	4.260473533327541e-07 / 3.0953447432169544e-06 / 1.0406702632518272e-05 / 6.714065008670566e-05	0.005531	4
182	TEP1_2	0.0000000008	0.00044390649641880996 / 0.00022291138567452008 / 0.007728913610011587 / 0.013802397731305673	7.69344257098905e-08 / 7.583371932539051e-07 / 1.1452916356973667e-05 / 1.4951877455973638e-05	0.00555	4
183	C1QTNF4_1	0.0000065502	0.018168011703420802 / 0.0008739549079227278 / 0.0021525218115003323 / 0.001823497355076137	1.4609518924208137e-05 / 1.9886833860209337e-08 / 3.327674138498291e-05 / 4.1425752762924387e-07	0.005754	4
184	SAMD9_2	0.0000000241	0.00015888299030502074 / 0.0005649656249134306 / 0.02294011174111297 / 2.9781970809395596e-05	1.4515338714501776e-07 / 1.0069662929413845e-06 / 3.079017964078163e-05 / 2.9239260560336778e-06	0.005923	4
185	INTS2_1	0.0000015748	0.0071423807687498436 / 0.005409509534570436 / 0.012055857526605073 / 1.7711409436331332e-05	3.636941582614834e-06 / 8.403767627067496e-07 / 0.000275721623498196 / 3.367956926486663e-05	0.006156	4
186	FUBP1_1	0.0000511078	0.00130787641161479 / 0.004251874133389083 / 0.003364552119188696 / 0.015851508245258043	1.9108608392104508e-07 / 2.9841202780652124e-07 / 5.350933661523097e-06 / 2.1932160234548787e-07	0.006194	4
187	RPAP1_1	0.0000410735	0.02301236512624726 / 0.0005345944155461007 / 0.001243129263120806 / 0.00047465333000177624	3.176104797820964e-07 / 2.5190175338691726e-06 / 2.1523203092437045e-06 / 9.149396149972693e-07	0.006316	4
188	HEXB_1	0.0000076128	0.015529327313804105 / 0.0013546126949011356 / 0.0060782790336966815 / 0.0035812987621354486	6.42491318793146e-10 / 4.577473133930505e-08 / 3.39530943939453e-09 / 2.7122303773993426e-06	0.006636	4
189	HNRNPU_1	0.0000032015	3.772462305351297e-05 / 0.00064922210107833 / 0.0010438255846085224 / 0.026018704719089503	1.000463952367771e-07 / 2.638911239632533e-07 / 7.660492345043258e-07 / 4.407301801134979e-06	0.006937	4
190	FUCA1_2	0.0000000004	7.228979888741317e-05 / 0.013714832441879614 / 0.007971606520234983 / 0.007402461335311882	2.0988769570938153e-06 / 1.9872137311126255e-06 / 3.537000242989197e-06 / 9.575754350455543e-05	0.00729	4
191	NOTCH2_2	0.0000000072	0.006230846374778002 / 0.003851986494620127 / 0.0034437522016521897 / 0.015866838196212218	1.4454100512704434e-07 / 8.519702743163462e-07 / 9.796096746463353e-06 / 3.089459803795722e-05	0.007348	4
192	CCT4_1	0.0000020961	0.0004974933526793384 / 0.008397433522606995 / 0.008173144283430401 / 0.012491622786737646	2.7241251268074896e-08 / 1.4220454346358598e-06 / 8.270539706935099e-07 / 7.806294817192854e-06	0.00739	4
193	UTRN_3	0.0000000000	2.360823500030083e-06 / 4.819891610542341e-05 / 0.01459161774480625 / 0.01624353394689184	9.96939171389334e-09 / 5.260467316300094e-07 / 3.5243167304031697e-06 / 9.884600038679634e-07	0.007721	4
194	CALU_1	0.0000004164	8.712601577854501e-09 / 0.029987683740818265 / 4.778480179883678e-05 / 0.0014562282237067896	5.266009225225312e-10 / 4.0454271359773727e-07 / 7.672203291248733e-08 / 5.85093501886766e-06	0.007873	4
195	PLAUR_1	0.0000000244	8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 / 0.029987683740818265	8.615162127229272e-11 / 9.681579901416002e-07 / 1.4437165409807745e-06 / 9.35433381095111e-06	0.007873	4
196	HIST1H3F_2	0.0000000051	0.0015927321289850582 / 0.023851866632585955 / 0.00016090253762067176 / 0.006218991828298577	2.1956145641009148e-08 / 0.00010324111552331347 / 6.744350520658004e-06 / 6.501852523462225e-05	0.007956	4
197	SHF_2	0.0000000138	0.001693689356850199 / 0.0014031215699221884 / 0.012735358967208718 / 0.017175407042679062	1.935898724207595e-07 / 7.846392075982059e-07 / 9.678320481712436e-06 / 8.427515550712705e-07	0.008252	4
198	CERK_1	0.0000008873	0.013244448613132145 / 0.0022351613397075614 / 0.015474072817082456 / 0.0029744892448975834	0.00020051688200258856 / 0.00018492952950495273 / 0.0012280052280709938 / 0.0005416554989378981	0.008482	4
199	TADA1_1	0.0000002147	0.016780696985377475 / 0.0005695162353950492 / 0.009231171890260521 / 0.00772762240557102	1.4508371309511671e-08 / 6.435719575006254e-08 / 4.82397274391162e-08 / 2.779770649698667e-07	0.008577	4
200	UBA7_1	0.0003624359	0.0005728902408745853 / 0.003242823752914826 / 0.0027568341257606386 / 0.03172797440821663	4.377541835767184e-08 / 1.4020761197150485e-06 / 2.9401803878641854e-05 / 6.058178438606368e-07	0.009575	4
201	SETDB1_1	0.0000003780	0.0026490796375761676 / 0.0030838618137353662 / 0.0004052971561229435 / 0.03955358967054088	5.084831070504725e-08 / 1.5437307336972335e-08 / 2.4314077044074555e-08 / 3.708419532637195e-06	0.011423	4
202	FEV_1	0.0000018489	0.033538144332397844 / 0.00028614552404424633 / 0.01249350392911133 / 5.910503776729101e-05	3.513392334373485e-06 / 3.0193991188193814e-06 / 4.261681658726496e-06 / 3.904348041550831e-06	0.011594	4
203	PLIN3_1	0.0000052675	0.00029139375190295606 / 0.009220967328515883 / 0.03147989324458417 / 0.008770410107355643	4.751419536263273e-07 / 1.5878609213360564e-06 / 2.5660205514983566e-05 / 1.1850407245136544e-05	0.012441	4
204	CAPZB_1	0.0000074431	0.020797363705116343 / 0.0062029903117365925 / 0.01708229147040032 / 0.012228646417111324	3.430820753789497e-07 / 7.116750242001532e-06 / 1.9457058230691574e-05 / 1.4739355201517365e-06	0.014078	4
205	PRR14L_1	0.0000287853	0.025082579510674555 / 0.0002021790532799894 / 0.012782548244800053 / 0.01903033340546255	3.0568724876555808e-06 / 1.7592986743744327e-05 / 0.0003036464804643225 / 9.900533456095719e-05	0.014274	4
206	SYT4_1	0.0000045133	0.015545833082593517 / 0.02041517410701112 / 0.005606155017185667 / 0.023315264256491483	0.0007991296587415927 / 1.5782237178697584e-07 / 3.4514435206822334e-06 / 3.6363448556754176e-05	0.016221	4
207	OSTM1_1	0.0000004769	0.00029139375190295606 / 0.014437131210731376 / 0.008770410107355643 / 0.042521980850760616	1.8325191636828767e-09 / 1.7933002396456563e-06 / 1.209386955631816e-05 / 2.8665654575872185e-06	0.016505	4
208	ALKBH2_5	0.0000000000	0.0006658217635395392 / 6.408084768025853e-06 / 0.04987195778126702 / 0.025098765971631444	1.084736492711166e-08 / 9.593642946100947e-08 / 1.132197770977069e-05 / 2.191320769137121e-05	0.018911	4
209	MSN_1	0.0000002383	0.01695446499444467 / 0.027498564129629463 / 0.014675290351873422 / 0.018771777160462803	4.599537647191073e-06 / 1.9086619291135215e-05 / 4.8131935092059315e-06 / 1.3273993329378002e-05	0.019475	4
210	ESYT2_2	0.0000000013	0.0030336578784421852 / 0.01671859601940339 / 0.015226777755356039 / 0.04496562784687137	3.165663675076115e-09 / 2.3423418225839996e-05 / 5.032307286753409e-07 / 1.2411450689986321e-05	0.019986	4
211	RSBN1_1	0.0000185080	0.03683753470884825 / 0.011413935706631708 / 0.017145541610166553 / 0.014660785392642973	1.433152382574118e-07 / 5.910344738541638e-08 / 2.5220601123022208e-05 / 4.2656913152557095e-06	0.020014	4
212	ATL3_1	0.0000008573	0.011413935706631708 / 0.014660785392642973 / 0.017443397981769932 / 0.03683753470884825	2.938478701650645e-07 / 1.2357184821505046e-06 / 1.34699746919262e-06 / 4.381675501436861e-06	0.020089	4
213	GLCCI1_2	0.0000000339	0.000506059688566897 / 0.006967423038249733 / 0.04616500613759174 / 0.02830343719752466	2.756128143638523e-10 / 8.727903434920509e-10 / 5.197443718190881e-07 / 0.00016721014291291134	0.020485	4
214	STX4_1	0.0000103251	0.017443397981769932 / 0.017145541610166553 / 0.03683753470884825 / 0.011413935706631708	1.149596541548471e-07 / 9.1652846360952e-06 / 2.8282830819547243e-06 / 3.479429274497365e-07	0.02071	4
215	ZFP36_1	0.0001056505	0.017443397981769932 / 0.017145541610166553 / 0.011413935706631708 / 0.03683753470884825	1.737842213973009e-07 / 8.045110852931203e-06 / 6.077495271342403e-05 / 1.3331815375742793e-06	0.02071	4
216	ITPR3_1	0.0000001347	0.04001855602158032 / 0.02473369613058651 / 0.002494297125613762 / 0.017644496874256163	3.1111051486214713e-07 / 3.1246898169649434e-07 / 5.066474066266959e-07 / 6.524401461141414e-06	0.021223	4
217	APEX1_1	0.0000125684	0.029245906890336886 / 0.039756863847419444 / 0.012044249045532097 / 0.005547335178190005	7.501855120464028e-09 / 2.210591549312696e-06 / 0.0010048532388054296 / 7.598158853857719e-07	0.021649	4
218	NAGK_1	0.0000090434	0.0359209982666861 / 0.02283925689865032 / 0.03203446148966057 / 0.007869203029856895	4.857892768176024e-12 / 1.5321698605219521e-06 / 3.1094588442870684e-07 / 1.03713103228835e-07	0.024666	4
219	CTSO_2	0.0000000001	0.011266491236640721 / 0.04019864979524411 / 0.009925247376618809 / 0.049822690026412035	3.138972714567624e-08 / 1.560503101825122e-08 / 9.567048792824493e-06 / 1.998510033084769e-06	0.027803	4
220	GAL3ST3_5	0.0000000000	1.4966990682807468e-07 / 2.827249605742276e-06 / 3.1413408717447276e-05	3.0226583395773654e-07 / 4.251989568762905e-06 / 9.932757607291931e-07	1.15E-05	3
221	UBA52_3	0.0000000000	1.3603516623392527e-05 / 6.029043389123571e-05 / 5.045497445639472e-05	5.851551410932261e-07 / 1.710172873999253e-08 / 1.2158482126235317e-05	4.14E-05	3
222	MSRB3_4	0.0000000000	6.46451222732421e-05 / 3.720566971124837e-05 / 8.695780204681589e-05	7.267015459944046e-07 / 4.887970470660509e-05 / 6.751019417131056e-05	6.29E-05	3
223	MTPAP_3	0.0000000001	2.4720937454568888e-05 / 1.2751616501556023e-05 / 0.00018587383065277118	4.2193212858195527e-07 / 3.403424981067467e-07 / 1.255056828139161e-06	7.44E-05	3
224	UBE2O_4	0.0000000000	0.00020771366206680562 / 1.528305625592724e-05 / 1.5417123239589966e-05	8.204970746839372e-07 / 1.2473665471568327e-05 / 2.207999415422632e-05	7.95E-05	3
225	RANBP17_1	0.0000004613	0.00013057839781136293 / 2.098169823270148e-06 / 0.00012418009082273935	1.5462113719102461e-06 / 1.0841250457737996e-05 / 0.0007974404623478325	8.56E-05	3
226	ZNF516_4	0.0000000000	3.872664033406607e-06 / 0.00012352623655085027 / 0.00014080284226678161	8.633851745836879e-06 / 3.646126773929292e-05 / 4.693534198442505e-05	8.94E-05	3
227	NKAIN1_3	0.0000000000	6.048904209077932e-07 / 0.0002827019572692268 / 4.565055181871741e-06	1.8963600971928307e-07 / 2.4597415093902517e-05 / 8.312648483856273e-05	9.6E-05	3
228	DHX9_3	0.0000000000	0.00031618213746396326 / 1.5079640407764188e-07 / 3.878104391115258e-05	7.324325851139409e-08 / 8.345673558891845e-07 / 5.455940168964712e-06	0.000118	3
229	TET1_4	0.0000000000	7.04443145456897e-05 / 0.00013097208813100302 / 0.00017715535475236788	7.420704863880182e-07 / 1.871920932527521e-06 / 1.2498158253814596e-06	0.000126	3
230	UHMK1_1	0.0000020860	0.00030051214168214937 / 6.606509042863372e-05 / 9.390951294242489e-05	5.795453634595254e-08 / 9.135482956883646e-09 / 5.202287615781549e-07	0.000153	3
231	KCNH8_2	0.0000000000	6.395893878746714e-08 / 0.0004951577945428809 / 6.246855784844429e-05	1.8797523362973878e-08 / 4.636654129462014e-07 / 1.099671115182553e-06	0.000186	3
232	PMEL_1	0.0000005663	2.098169823270148e-06 / 1.384655004104117e-06 / 0.0006273187563236247	6.845101785005541e-09 / 2.3534233465189457e-06 / 7.679394256913984e-07	0.00021	3
233	TMEM177_2	0.0000000000	0.000218258066644831 / 2.729001089528698e-05 / 0.0005268025057445726	5.209193027162048e-08 / 7.210516358215353e-07 / 8.65292135655517e-06	0.000257	3
234	P4HB_3	0.0000000000	7.235087963937188e-05 / 0.00020977095849751892 / 0.0006140291296563689	1.5481316963269385e-06 / 1.2667727790601262e-05 / 2.2318101021362054e-05	0.000299	3
235	GLB1_2	0.0000000001	0.0008060555543976513 / 0.00015263556465626687 / 0.0002492824297492718	5.95245025264109e-07 / 3.0646460084359855e-06 / 2.0252846047441925e-05	0.000403	3
236	NIPSNAP1_5	0.0000000000	7.0049869888978436e-06 / 0.0005153457051148798 / 0.0006955168425803274	1.5111991034910146e-07 / 1.7955354168874533e-06 / 6.9569188414230535e-06	0.000406	3
237	STOX2_4	0.0000000003	4.1961269753906035e-05 / 0.0010880952015806498 / 0.00010503474822771901	8.316576707748038e-07 / 1.514815251496678e-05 / 3.9477756451806046e-06	0.000412	3
238	HIC2_5	0.0000000000	4.726033274744903e-06 / 0.00013382198113446112 / 0.0013349789650252575	9.611997971680818e-09 / 1.1620332716585593e-05 / 3.9355477345741505e-05	0.000491	3
239	DDX25_1	0.0000003731	8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896	1.6097112876531916e-08 / 3.2052124199850265e-08 / 1.4170604850554317e-07	0.000501	3
240	DNMT3A_1	0.0000003165	8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05	3.5247387941347504e-08 / 6.731804150774537e-06 / 1.2896794234236179e-05	0.000501	3
241	EXT2_1	0.0000003436	8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05	2.0783635717550663e-12 / 9.054121086432515e-07 / 2.0219531513922313e-05	0.000501	3
242	FAM129B_1	0.0000000190	8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896	6.60672131957345e-08 / 5.537377478544649e-08 / 4.1732948235118237e-07	0.000501	3
243	GINM1_1	0.0000002753	8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05	5.046050215569822e-09 / 5.428070521726932e-08 / 2.1701147223144043e-06	0.000501	3
244	HNRNPA1L2_1	0.0000000756	8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896	1.2976171138488909e-09 / 4.5877377333254656e-07 / 1.6836213911883948e-06	0.000501	3
245	MAN1B1_1	0.0000001522	8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05	3.0241063676746706e-11 / 1.5906368364620238e-09 / 1.318311055073274e-07	0.000501	3
246	TACC1_1	0.0000024323	0.0014562282237067896 / 4.778480179883678e-05 / 8.712601577854501e-09	6.120199026321514e-07 / 4.1123437302256347e-07 / 1.0614723925305345e-08	0.000501	3
247	RIPK1_5	0.0000000000	6.840228317523313e-05 / 0.0009512875629473391 / 0.0005924452898671693	1.5712671052120772e-06 / 4.09648566039462e-06 / 3.7135622189006208e-06	0.000537	3
248	ZBTB4_3	0.0000000000	0.0005037641948066041 / 4.1029029786791e-05 / 0.0011809756046229313	1.117525634308104e-05 / 2.721755300189734e-07 / 5.303486617820998e-05	0.000575	3
249	TLN1_5	0.0000000000	1.9703021048281005e-05 / 0.0005523542769980133 / 0.001186882005547644	2.022661269835003e-07 / 7.938143861075808e-05 / 8.872728066213042e-06	0.000586	3
250	PCBP3_1	0.0000002605	8.712601577854501e-09 / 0.0006110060061203364 / 0.0014562282237067896	7.776240359663578e-08 / 1.638864761384365e-06 / 1.2093871604348117e-06	0.000689	3
251	KIDINS220_2	0.0000000000	0.0018859337356087994 / 0.0001930893136831812 / 4.710776942634132e-06	5.072414419210524e-06 / 1.9800037664169994e-06 / 3.568737378774764e-05	0.000695	3
252	MYH9_4	0.0000000000	0.0011716362540399527 / 2.5874889458489842e-05 / 0.00098592835353018	1.1606044222659936e-05 / 5.315659303841256e-07 / 0.0002008409108671274	0.000728	3
253	C2orf43_4	0.0000000000	5.393578869543922e-07 / 0.0023453445326236527 / 1.354525793237082e-06	6.595211500412567e-08 / 3.985671655723259e-07 / 6.693718279433329e-07	0.000782	3
254	CFLAR_5	0.0000000000	2.366050283623384e-07 / 1.8250670479244966e-06 / 0.0026884317876910953	4.986931710131805e-06 / 3.457834181885606e-06 / 1.5979548021423277e-06	0.000897	3
255	RAB27A_5	0.0000000000	4.235470787154264e-07 / 0.00048364115746124477 / 0.002294886679155574	1.5348969527407146e-08 / 1.8046897740630015e-06 / 4.1788406415060826e-05	0.000926	3
256	PLSCR4_2	0.0000000029	4.859413804591664e-05 / 0.0027548209719256856 / 0.00020561631972662475	3.3117537208770918e-09 / 1.148805004150062e-06 / 4.664969309642537e-06	0.001003	3
257	RPUSD4_1	0.0000007330	0.001066805887839933 / 0.0005152101842532016 / 0.0015298583359982347	2.3615410532322286e-05 / 4.319838908046999e-06 / 0.0002330489716331065	0.001037	3
258	MPST_3	0.0000000016	0.00013736583753548478 / 0.0030443962453463847 / 8.033145753215765e-06	3.289559261620218e-06 / 3.976886270875369e-06 / 1.171567023312239e-06	0.001063	3
259	MSN_1	0.0000002015	0.0019027179320774803 / 0.0012733956455115425 / 0.0003168019030192227	9.67855150073715e-08 / 3.184222031943731e-08 / 4.6792815745596373e-07	0.001164	3
260	TGFB1I1_1	0.0000000689	0.0012733956455115425 / 0.0003168019030192227 / 0.0019027179320774803	9.602262969345956e-07 / 1.898080280214667e-06 / 4.85147907436071e-06	0.001164	3
261	PRMT1_2	0.0000000003	2.8649381309321584e-06 / 0.00013104001909797732 / 0.00341452788547584	3.7442073966474697e-11 / 2.696236533103196e-06 / 4.175789992611833e-06	0.001183	3
262	AGPAT3_3	0.0000000000	0.0009240199113069562 / 0.001726211324732259 / 0.0009222051384671301	1.4076606607890667e-05 / 6.064432655122854e-06 / 0.00046211741435037205	0.001191	3
263	NUPR1_2	0.0000000008	1.2731341624968911e-05 / 5.8997927541035875e-06 / 0.003561757705418032	6.730910090199648e-07 / 2.3445593630205304e-06 / 1.3063148311515809e-05	0.001193	3
264	RNPC3_2	0.0000000375	0.0025602598027028244 / 5.469917899643988e-05 / 0.0010104633264639477	1.393467985718326e-06 / 7.829150593953611e-07 / 0.00010845460486238517	0.001208	3
265	S100A6_2	0.0000000006	0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08	1.7609429749647884e-07 / 5.870724758098998e-07 / 1.1681749490132842e-07	0.001224	3
266	GADD45B_2	0.0000000000	0.00010634683697229356 / 0.003790365456096317 / 1.8397621446509385e-05	1.705317052907576e-07 / 8.878912678862584e-06 / 2.2556761049368962e-07	0.001305	3
267	IRF2_2_5	0.0000015405	0.0008574554508689445 / 0.003180287587180633 / 6.994095656900796e-05	9.872538086030946e-08 / 1.5355274708245824e-06 / 2.245172851097339e-06	0.001369	3
268	MVP_2_3	0.0000000046	0.00024759203487775524 / 1.1168409277359634e-06 / 0.004671632294386495	1.4353154937155882e-08 / 5.633740184888267e-07 / 7.385772453731096e-05	0.00164	3
269	GTF2H5_2	0.0000000066	0.0002128703129063878 / 0.002908963894359682 / 0.0018958315428404735	5.915610064271708e-09 / 5.737302226316655e-07 / 1.2839131009976642e-05	0.001673	3
270	AGTPBP1_2	0.0000000112	0.00010643560926875712 / 0.0014494282385407017 / 0.003851986494620127	3.4005559000932834e-05 / 5.086114917232466e-05 / 2.3120980016650736e-05	0.001803	3
271	TAGLN2_5	0.0000000000	0.0023516155321212286 / 0.0005452799037971314 / 0.002719578191920108	5.193860370029491e-08 / 1.8066076033567137e-05 / 2.887575861701981e-05	0.001872	3
272	CCNT1_4	0.0000000000	0.00022838881607180578 / 2.554651598059182e-05 / 0.006324061390967165	5.780726368884951e-06 / 4.298018160630921e-06 / 8.210854046814278e-06	0.002193	3
273	KCNN4_1	0.0000000002	0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227	1.128508207742848e-07 / 3.8845776675460915e-08 / 1.2490905944573221e-07	0.002278	3
274	PEA15_1	0.0000000021	0.004613449756294485 / 0.0003168019030192227 / 0.0019027179320774803	3.828734914704096e-08 / 3.8329007469588033e-07 / 4.539908056270449e-05	0.002278	3
275	SAMD9_1	0.0000020075	0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227	1.631780084189698e-08 / 1.293907975082848e-05 / 2.4553942312433883e-05	0.002278	3
276	TRADD_3	0.0000000103	0.0009229889305125405 / 0.005966882987573243 / 0.00022527887387849618	1.9518812703705133e-06 / 0.0006939505597308152 / 1.9336719955298165e-06	0.002372	3
277	TAF5_3	0.0000000136	0.0003947059228531657 / 0.00045641021220350523 / 0.006335832620557736	1.7233340819541832e-07 / 2.5952887221237527e-06 / 8.18333648588888e-05	0.002396	3
278	EFHD2_4	0.0000000000	0.00723849757956334 / 1.3696651981584819e-05 / 6.311409747603608e-05	2.4861210722153842e-05 / 2.247788787753732e-05 / 1.516759330888414e-06	0.002438	3
279	YIPF2_1	0.0000006993	0.0008973831238703076 / 0.0005658979552839525 / 0.0060047412034100744	9.922731214680193e-08 / 7.852806908257148e-06 / 0.0001985413552316056	0.002489	3
280	ZBED4_2	0.0000001314	0.0007128826028020409 / 0.0020168985989813806 / 0.00482573534583834	9.098868701321864e-08 / 1.2243260078905274e-05 / 0.0008067113425139145	0.002519	3
281	RAB3C_1	0.0000014208	0.0012733956455115425 / 0.004613449756294485 / 0.0019027179320774803	5.90994322935669e-07 / 1.1108797731264583e-05 / 4.4376112397274685e-05	0.002597	3
282	FOSL1_4	0.0000000000	0.007490059087712426 / 0.00021444125068471832 / 0.00012920787797071663	5.556372147557157e-06 / 7.999218077760667e-07 / 2.9367679374215882e-05	0.002611	3
283	INA_2	0.0000002325	0.000506059688566897 / 0.006967423038249733 / 0.000365164824725025	2.655622703010865e-07 / 6.037515871423344e-07 / 0.001167614468808287	0.002613	3
284	FLVCR1_2	0.0000000042	5.3340489000579145e-05 / 0.0015899100236963135 / 0.006521228618588356	1.302715543173824e-07 / 3.714456265544689e-05 / 1.704949565638429e-05	0.002721	3
285	ATF7IP2_5	0.0000000000	0.0032839512279112418 / 0.002993599664223763 / 0.002476029139206104	8.537589066325822e-06 / 2.5436790588774414e-05 / 5.142377607346069e-07	0.002918	3
286	S100A10_1	0.0000008705	0.0030838618137353662 / 0.0016555906467057811 / 0.004531342266561176	1.1613890918983097e-06 / 1.6946838169885616e-05 / 9.665990417390237e-05	0.00309	3
287	TRIP6_1	0.0000002147	6.392429369799613e-05 / 0.008158453075892491 / 0.0012146763275784356	3.2750776669883485e-08 / 4.272773668654882e-07 / 5.404314030094148e-07	0.003146	3
288	EIF3J_2	0.0000000002	0.005021029517387429 / 0.004594623942981826 / 0.0005725315156474846	1.0666101484276558e-06 / 8.707499404147844e-06 / 7.206761532626187e-07	0.003396	3
289	CASP4_1	0.0000000780	0.008158453075892491 / 0.0012146763275784356 / 0.0011036487237694873	2.347967797408527e-08 / 1.0559189019803553e-06 / 3.278522050115709e-06	0.003492	3
290	NSL1_2	0.0000000033	5.3340489000579145e-05 / 0.011092727550841517 / 5.792866128396694e-05	2.2018205271807595e-07 / 0.00024742638651566884 / 3.7695931576460654e-06	0.003735	3
291	VASP_1	0.0000006404	0.009220967328515883 / 0.00029139375190295606 / 0.002271551295087959	1.683199820716066e-07 / 2.799847052848426e-07 / 5.915001438135837e-07	0.003928	3
292	COG2_3	0.0000000010	0.012184597869329615 / 0.00017818061059800717 / 3.3817330366409276e-05	9.88977547194958e-07 / 9.135799923405938e-08 / 3.6569660447432056e-05	0.004132	3
293	STMN4_3	0.0000000000	2.061341498862413e-06 / 0.013557269953071502 / 0.00016739297171412964	1.1827971870760236e-07 / 1.7028450668349932e-05 / 2.2310679101285705e-05	0.004576	3
294	ARID2_1	0.0000005167	0.009220967328515883 / 0.00029139375190295606 / 0.004557941079021841	2.2639222896451386e-07 / 1.109801352982852e-06 / 2.1017914639263102e-07	0.00469	3
295	TMEM145_2	0.0000000541	0.011857375508327873 / 0.0019384937218085618 / 0.0003086352962437011	3.703004816743222e-08 / 9.472094543228691e-06 / 3.7868771404399016e-07	0.004702	3
296	RPS28_2	0.0000000062	0.0013196713645063731 / 0.00015680243457987764 / 0.013122781516773055	2.4859140381808595e-07 / 8.661018242204261e-07 / 1.0278447900767023e-05	0.004866	3
297	BHLHB9_5	0.0000000000	0.000833093052382085 / 0.0017373454847881562 / 0.012094762315019585	0.0003876834856951191 / 0.00025814098757798783 / 0.0012619942783536312	0.004888	3
298	CCT3_2	0.0000003320	0.0053229089046933666 / 0.0035672102749117456 / 0.006424879308109518	1.385234000351963e-09 / 1.1973928792856672e-07 / 8.271151178245213e-07	0.005105	3
299	ZBTB39_1	0.0000012961	0.0002459835698877307 / 0.012131971219889692 / 0.003904810749383955	1.947682987909157e-09 / 4.769808257064375e-06 / 1.009907236026598e-05	0.005428	3
300	TGFBI_1	0.0000001859	0.014968932619439228 / 0.00029139375190295606 / 0.002271551295087959	8.323645474851572e-06 / 2.8646241152477385e-06 / 2.2007597669701546e-05	0.005844	3
301	DRAM1_2	0.0000000007	3.95395916749111e-05 / 0.005028962391482225 / 0.012655371032190181	7.334418459565927e-07 / 2.9757670605999017e-06 / 7.803574545937928e-05	0.005908	3
302	TTC9B_4	0.0000000010	3.2451983838054593e-06 / 0.0027782153739561613 / 0.015336438182107533	5.579389394627073e-06 / 2.6478455347372e-05 / 6.774767693632554e-05	0.006039	3
303	CRABP1_2	0.0000000000	0.00018053504491942103 / 0.0006013127917976173 / 0.017420025549877295	3.6420294337565723e-08 / 4.7891636027032046e-05 / 2.4547340474687967e-05	0.006067	3
304	PRNP_1	0.0000012041	0.008158453075892491 / 0.01165101001080378 / 0.0011036487237694873	1.1937594193840056e-07 / 3.852111240660634e-06 / 7.982699562459387e-07	0.006971	3
305	RNF216_2	0.0000000710	0.01978912870326623 / 0.0009038593586046481 / 0.001339659580920153	1.2928230810660568e-06 / 1.509161544583804e-07 / 3.464852330723318e-06	0.007344	3
306	KCNH2_1	0.0000005910	0.0011929519758551942 / 0.013144247549246738 / 0.007698641086675404	4.050881868723152e-06 / 5.993445368097023e-06 / 9.184683537215863e-05	0.007345	3
307	HDAC2_1	0.0000111884	0.0013546126949011356 / 0.015529327313804105 / 0.0060782790336966815	8.678070199327975e-10 / 9.165188556262711e-07 / 1.9640719268488575e-07	0.007654	3
308	LDLRAD3_2	0.0000000086	0.000790463498248653 / 0.022196441234578132 / 2.1369034750623554e-06	2.3758722136689975e-06 / 9.69193707515232e-05 / 3.165236790324336e-05	0.007663	3
309	DLG2_1	0.0000004953	9.390951294242489e-05 / 4.611763366846969e-05 / 0.023379270483941148	1.6435897498809227e-05 / 8.947838561493191e-07 / 0.0005491970493346228	0.00784	3
310	ABHD2_2	0.0000007167	0.007702284030015268 / 0.015157007205383797 / 0.002098496534836373	6.150334665817541e-07 / 2.79918960850902e-06 / 1.3380586388949062e-06	0.008319	3
311	FICD_1	0.0000000879	0.00042879723237597764 / 0.003993715376548959 / 0.02118368053863915	2.9785947869700167e-06 / 6.873856442248643e-07 / 6.404598440436032e-07	0.008535	3
312	EML5_1	0.0000186293	0.0003816779304374477 / 0.007313973432554173 / 0.019582037452342965	1.768922156010669e-08 / 3.733774907814613e-07 / 8.463320131580384e-05	0.009093	3
313	ZNF280B_1	0.0000176080	0.0002021790532799894 / 0.012782548244800053 / 0.015382714940475899	4.16735367252946e-06 / 1.8932170047411166e-06 / 0.0006150439183333181	0.009456	3
314	MAST1_1	0.0000012460	0.0030838618137353662 / 0.0016555906467057811 / 0.02419315699804896	1.008321219643804e-08 / 6.59179220363995e-08 / 2.8729044379438386e-06	0.009644	3
315	NBR2_4	0.0000000013	0.0030139413806392025 / 0.02262700624929458 / 0.004062778899218961	2.6809213542125635e-07 / 3.3592733116787e-06 / 5.084507985309251e-05	0.009901	3
316	ZSCAN16_1	0.0000021993	0.009406629582018086 / 0.007054606953047138 / 0.013414705614259708	3.1919700086632823e-08 / 4.241176857088593e-06 / 1.10182899392691e-05	0.009959	3
317	CD109_1	0.0000004857	0.0030838618137353662 / 0.026132194840960694 / 0.0016555906467057811	4.1459663612593765e-07 / 1.133270373704853e-05 / 6.95591696890365e-07	0.010291	3
318	ASCL1_1	0.0000012961	8.712601577854501e-09 / 0.0014562282237067896 / 0.029987683740818265	6.622928776298776e-08 / 4.986303622240574e-07 / 5.121638955023879e-05	0.010481	3
319	PRCC_2	0.0000000009	0.02916029058932568 / 1.4053286193768942e-05 / 0.0033436620457161664	4.234540029087047e-09 / 7.396677617376084e-08 / 5.762915371340719e-06	0.010839	3
320	SYPL1_3	0.0000000001	0.0010868506221494473 / 0.03062224194622656 / 0.0008798790932645847	1.8036241827089262e-07 / 1.170707624311846e-06 / 8.621104111789159e-06	0.010863	3
321	CACNA1B_3	0.0000023253	0.0006313127973618962 / 0.026533133928238382 / 0.00548175365183452	4.657105147722875e-06 / 0.00011767035322254456 / 0.0009513496148143766	0.010882	3
322	FEV_3	0.0000000016	0.0018157417923330308 / 0.0005005652894286239 / 0.03138718307129687	5.9293955966041735e-08 / 1.9491788120934706e-06 / 3.089744526549523e-05	0.011234	3
323	VSTM2A_2	0.0000000860	0.000506059688566897 / 0.02830343719752466 / 0.005186853257558283	4.451709831952587e-07 / 0.0006571117480683702 / 0.0019723456239841616	0.011332	3
324	DOC2A_1	0.0000176432	0.00025234279143195943 / 0.005397134900618702 / 0.028677370706029427	2.097886384356248e-06 / 4.3459478389049724e-07 / 7.808876942721705e-07	0.011442	3
325	MTR_1	0.0000001011	9.388757698010748e-05 / 0.015063580358728427 / 0.020113164514031456	2.0462926382898192e-05 / 2.0838053089232e-06 / 0.0006005512194214275	0.011757	3
326	TMEM184B_1	0.0000052583	0.017443397981769932 / 0.002318126437551203 / 0.017145541610166553	5.074118788922354e-08 / 1.528139375785279e-07 / 1.361457730245486e-06	0.012302	3
327	ARID2_3	0.0000002768	0.005599828148522198 / 0.014996743361982036 / 0.018170592466726792	9.116542240665922e-09 / 1.5456378377669386e-06 / 4.750875211998681e-06	0.012922	3
328	TSEN54_2	0.0000000000	0.00021036438824558563 / 0.0016249672415913465 / 0.03836197892479358	1.419950215795548e-07 / 1.6203351133132878e-07 / 1.5720016310468745e-05	0.013399	3
329	LAMP2_1	0.0000061826	0.0006291978832262494 / 0.017133475216302412 / 0.02253012830344572	2.3046914608799517e-06 / 5.662655646886999e-07 / 4.09648566039462e-06	0.013431	3
330	GPX8_1	0.0000006021	0.007054606953047138 / 0.009406629582018086 / 0.024046868563271137	7.3135246584530174e-09 / 6.656311691714102e-10 / 6.25392798502714e-06	0.013503	3
331	PRIM1_1	0.0000003223	0.0019943829025712437 / 0.032332967518234994 / 0.006230194892575304	7.867184240616801e-06 / 5.037758463198267e-08 / 2.7703126525457583e-06	0.013519	3
332	MMD_3	0.0000000000	0.00026462416519984375 / 0.04009931021218081 / 0.0018585225095028022	3.265086074696618e-08 / 3.8983782729439324e-05 / 5.764266261871919e-06	0.014074	3
333	HSPD1_1	0.0000016837	0.029245906890336886 / 0.012044249045532097 / 0.0010265738076671066	3.4847461970373735e-08 / 5.585527560266155e-06 / 7.023185063013887e-06	0.014106	3
334	TNFRSF12A_5	0.0000000000	0.032768876151590194 / 0.009211796235391962 / 0.0006064986533695733	9.11501895060049e-06 / 1.6191708335697414e-05 / 3.563543914807607e-06	0.014196	3
335	PLP2_4	0.0000000002	0.043329534197300235 / 4.1971169891966186e-05 / 0.00011139453192955434	4.795701871201485e-07 / 3.953822199723069e-06 / 0.002463554449974249	0.014494	3
336	SNX3_1	0.0000004514	0.012469105184180684 / 0.009827915816152012 / 0.02176087444903759	1.575326562154422e-07 / 1.0953632726584286e-07 / 4.669480873853378e-06	0.014686	3
337	SMC3_1	0.0000067784	0.01903033340546255 / 0.025082579510674555 / 0.0002021790532799894	7.004137458574501e-07 / 7.700331048016097e-07 / 1.9353158268148655e-06	0.014772	3
338	ARHGAP1_1	0.0000026967	0.017145541610166553 / 0.011413935706631708 / 0.017443397981769932	1.3146010474489681e-05 / 4.804751045086965e-06 / 2.132159178159428e-06	0.015334	3
339	LPP_1	0.0000033409	0.01487722458866696 / 0.0017052769733922298 / 0.02985182122259529	1.546223090931648e-07 / 4.2508307877523196e-08 / 1.4414883845347043e-06	0.015478	3
340	MGAT1_1	0.0000004092	0.014660785392642973 / 0.017145541610166553 / 0.017443397981769932	1.7966684116150096e-06 / 5.116593940505276e-06 / 1.3410770868177782e-06	0.016417	3
341	TNFRSF1A_3	0.0000000002	0.0028067534068265437 / 0.00042105945887903654 / 0.048060814464615735	1.0121421064420374e-05 / 7.452615942617135e-06 / 9.353097000119014e-05	0.017096	3
342	C12orf10_1	0.0000001344	0.01695446499444467 / 0.014675290351873422 / 0.02095078822868191	9.883275335709048e-07 / 3.3979035604139886e-07 / 1.4183511170080205e-05	0.017527	3
343	KLF15_1	0.0000009834	0.02839442496647524 / 0.011495528751480646 / 0.017748059549662194	2.539351518692909e-07 / 3.996180547635244e-06 / 3.72884546184977e-07	0.019213	3
344	RSL1D1_1	0.0000024224	0.029245906890336886 / 0.029072859932669184 / 0.001209619547547507	1.928466390137773e-09 / 1.7774626241888566e-05 / 2.7621925072470266e-06	0.019843	3
345	CDK2AP2_1	0.0000069090	0.03413875749258289 / 0.008813705248904322 / 0.017145541610166553	7.980991943354118e-06 / 9.182341905056802e-07 / 6.046703803974713e-06	0.020033	3
346	ENOX1_1	0.0000096565	0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322	8.46495419886903e-08 / 2.477238173018046e-06 / 5.706880115624909e-06	0.021032	3
347	KLHL36_1	0.0000009988	0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322	8.55516827501211e-06 / 5.0553384219596765e-06 / 3.3892208678789174e-05	0.021032	3
348	C1R_1	0.0000103261	0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825	5.223576944443697e-10 / 1.278142542397936e-07 / 9.066430827258057e-08	0.021898	3
349	DLL3_1	0.0000022545	0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825	2.879808838966571e-07 / 6.993476243540988e-06 / 7.726331259366366e-07	0.021898	3
350	NPC1_1	0.0000013000	0.023996288711547777 / 0.014582218475483697 / 0.027344357279935363	5.764157631131607e-07 / 2.4200174195178475e-06 / 8.775983171046948e-07	0.021974	3
351	BPTF_1	0.0000012059	0.0010265738076671066 / 0.029245906890336886 / 0.039756863847419444	2.75081594060756e-06 / 1.849240931697844e-06 / 9.833875885810182e-05	0.023343	3
352	CCNB1IP1_1	0.0000010768	0.029245906890336886 / 0.0010265738076671066 / 0.039756863847419444	5.5727604077632575e-08 / 1.0079899592111368e-06 / 6.245632688934216e-06	0.023343	3
353	NPC2_1	0.0000110270	0.03683753470884825 / 0.017443397981769932 / 0.017145541610166553	2.895916979465306e-07 / 4.350257929933473e-06 / 5.881485803416461e-06	0.023809	3
354	ABAT_3	0.0000000001	0.034052040127872246 / 0.006551644901500213 / 0.03343958590730531	4.991017761660758e-05 / 1.6284836400790797e-06 / 5.991633249924668e-06	0.024681	3
355	CEP170_3	0.0000000001	2.3886446874268867e-06 / 3.5555136352418323e-06	8.64144400156011e-07 / 9.9452244969615e-06	2.97E-06	2
356	NUCB1_3	0.0000000000	9.120027832512087e-06 / 4.9060208885387406e-06	4.76082633817649e-08 / 1.542543895417389e-06	7.01E-06	2
357	LAMP1_5	0.0000000000	7.561570077756679e-06 / 7.75081771574093e-06	1.0518690072819026e-09 / 7.017816798332179e-06	7.66E-06	2
358	MAP4_2	0.0000000001	2.1541055929197527e-08 / 1.9308695609987287e-05	3.93734689573353e-09 / 7.038983428807821e-07	9.67E-06	2
359	MSH6_1	0.0000000525	2.098169823270148e-06 / 1.7711409436331332e-05	2.9237170575647894e-07 / 3.223701677601978e-06	9.9E-06	2
360	NECAP2_5	0.0000000000	1.1734627356832365e-05 / 1.4727302282280241e-05	6.34621052304883e-05 / 9.263010355358496e-05	1.32E-05	2
361	RFX7_1	0.0000006461	1.8023978844296698e-06 / 3.772462305351297e-05	1.3777889602205754e-05 / 5.134420163197374e-06	1.98E-05	2
362	LOXL1_1	0.0000000613	8.712601577854501e-09 / 4.778480179883678e-05	3.7451852636473064e-09 / 3.520223337931936e-07	2.39E-05	2
363	RAB11FIP5_1	0.0000003435	8.712601577854501e-09 / 4.778480179883678e-05	8.30614778438761e-09 / 1.875106499909923e-05	2.39E-05	2
364	SYNC_1	0.0000000544	8.712601577854501e-09 / 4.778480179883678e-05	1.8300368947275955e-09 / 1.1156949187536687e-06	2.39E-05	2
365	MYT1_2	0.0000000000	4.852661376064752e-06 / 5.1682368391364916e-05	6.5288974923630765e-06 / 2.33136261456977e-05	2.83E-05	2
366	CNTNAP2_4	0.0000000000	1.9536120969160626e-05 / 4.855499097832519e-05	2.69621468363523e-05 / 0.0005954550144190784	3.4E-05	2
367	SMARCA5_4	0.0000000000	3.104247296762117e-05 / 4.761108954152855e-05	1.84536023077791e-05 / 3.4952774168035884e-05	3.93E-05	2
368	B3GNT9_4	0.0000000000	4.759424034644978e-06 / 0.00012294606259085342	1.6260769696128954e-06 / 0.00010634285087971367	6.39E-05	2
369	GAL_2	0.0000000005	1.1566938688714122e-08 / 0.0001375276427082929	1.8119993137342534e-06 / 0.0013149790281325572	6.88E-05	2
370	TRIM56_5	0.0000000000	0.00014260412953936538 / 2.3479938806380944e-08	3.859067457796533e-06 / 3.656262715818669e-07	7.13E-05	2
371	CRIM1_3	0.0000000004	4.8106808740888186e-05 / 0.00010014977875691996	9.846475238177379e-06 / 5.579017068717648e-08	7.41E-05	2
372	PNMA3_5	0.0000000000	1.701692255505357e-06 / 0.00014830625115725305	2.0336906370795427e-06 / 9.840133053947521e-06	7.5E-05	2
373	HIST3H2A_3	0.0000000000	7.513947614807362e-05 / 0.00011429921060857062	1.068586509856438e-06 / 3.0653385085725396e-07	9.47E-05	2
374	ATCAY_5	0.0000000000	5.4278236645845715e-06 / 0.00020534480614177087	7.732934718383503e-06 / 2.75413488861665e-05	0.000105	2
375	SMARCA4_2	0.0000000016	2.321730111153503e-06 / 0.00022187513044902743	2.120449751487153e-08 / 3.5992692804583596e-05	0.000112	2
376	LIN28B_2	0.0000000000	1.216331498209144e-06 / 0.00029774828278028234	1.1201154484621356e-09 / 7.926073637103903e-06	0.000149	2
377	OLFML2A_5	0.0000000000	8.951974512115386e-05 / 0.00034027362168927155	9.130549898240117e-07 / 2.4504382448983827e-06	0.000215	2
378	ACP1_5	0.0000000000	6.364279791640112e-06 / 0.0004408162010949017	1.6688642528792083e-06 / 1.8017876923145952e-05	0.000224	2
379	ACTL6B_3	0.0000000040	0.0003057625951752015 / 0.00015450477319284894	1.060226377821344e-06 / 2.1353909002247907e-05	0.00023	2
380	PHF21B_4	0.0000000000	7.623480320281502e-07 / 0.0004987725781895633	5.2768179043587e-06 / 1.09188294232324e-06	0.00025	2
381	BAZ1A_1	0.0000069836	0.00064922210107833 / 1.8023978844296698e-06	1.6595910049899672e-07 / 4.925632831272468e-06	0.000326	2
382	TMEM30A_1	0.0000022161	0.0006240411433431414 / 5.2470753247363745e-05	3.5429731576541734e-08 / 5.5462823621098335e-08	0.000338	2
383	NOL11_2	0.0000000000	0.00046464339325169037 / 0.0002564595505663515	5.933716019020396e-07 / 7.456072877479674e-09	0.000361	2
384	BEND4_5	0.0000000000	1.5777685999047575e-06 / 0.0007208108997517884	5.3901186417921756e-11 / 2.815995740727121e-07	0.000361	2
385	ELOVL1_3	0.0000000020	0.0006923847970197059 / 3.196763725059841e-05	2.677497381339075e-07 / 0.00021491113805745135	0.000362	2
386	PFKM_4	0.0000000000	0.0007309049115603717 / 8.501642925216299e-06	9.403882200312194e-08 / 7.819007418155511e-07	0.00037	2
387	NMNAT1_2	0.0000000129	0.0004526675305989492 / 0.0003016808649104736	9.397755887797147e-06 / 0.00010313370779319529	0.000377	2
388	TIGD1_2	0.0000000029	0.00015234942199771114 / 0.000651352109304205	8.064616695114456e-07 / 4.491126688099632e-05	0.000402	2
389	ARL1_5	0.0000000000	1.694043434756899e-05 / 0.0008334490663588983	2.2314679547176197e-07 / 4.126172052886268e-06	0.000425	2
390	CPLX1_4	0.0000000002	0.0008665554418518524 / 5.737321179382452e-06	5.87667964571385e-06 / 3.438314234654185e-05	0.000436	2
391	PAX6_5	0.0000000000	0.00027854752254638905 / 0.0006006286848231235	1.3031733956534446e-07 / 2.2950534119176534e-06	0.00044	2
392	ANXA2_5	0.0000000000	0.00022245643971115814 / 0.0008228851369949542	0.0002774948155360362 / 4.3531858337072534e-05	0.000523	2
393	BHLHE41_1	0.0000003123	3.679473658399758e-05 / 0.0010281262291342236	5.186786515718226e-05 / 4.276807002378442e-05	0.000532	2
394	DPYSL5_2	0.0000000245	0.0005017064663366604 / 0.0006658727095010238	1.0246351818305243e-08 / 2.9985183250414335e-08	0.000584	2
395	NCL_5	0.0000000000	0.0001902762125730563 / 0.0010196091469089486	1.1394612086185451e-07 / 5.477181895031346e-05	0.000605	2
396	NEK6_3	0.0000000000	0.00042892841962168427 / 0.0007955623084328148	4.625637105430227e-06 / 1.9802846632838944e-05	0.000612	2
397	ADAM11_1	0.0000014021	0.00020676489909411184 / 0.0010623957357494855	6.162977005662482e-06 / 1.5065356540452738e-05	0.000635	2
398	BMP1_1	0.0000001479	8.712601577854501e-09 / 0.0014562282237067896	1.0629725087716493e-09 / 3.3335712676585927e-10	0.000728	2
399	CRABP1_1	0.0000012003	8.712601577854501e-09 / 0.0014562282237067896	1.0032588981222376e-06 / 1.6633089557898398e-05	0.000728	2
400	CREB3_1	0.0000002396	8.712601577854501e-09 / 0.0014562282237067896	3.248193062600497e-07 / 1.8160839243636814e-05	0.000728	2
401	CTSB_1	0.0000004048	0.0014562282237067896 / 8.712601577854501e-09	2.7850840733739764e-08 / 6.154886102926167e-07	0.000728	2
402	GLB1_1	0.0000009020	0.0014562282237067896 / 8.712601577854501e-09	5.1549922184344e-09 / 2.2049835157073303e-11	0.000728	2
403	LGALS3_1	0.0000001910	0.0014562282237067896 / 8.712601577854501e-09	3.755610443792837e-07 / 1.150827659828279e-08	0.000728	2
404	SMPD1_1	0.0000000902	8.712601577854501e-09 / 0.0014562282237067896	1.2661160783158677e-07 / 1.5916398320881086e-06	0.000728	2
405	GTPBP4_1	0.0000001295	0.00028286232014178015 / 0.001443320215490813	1.1507531465572511e-05 / 8.380217354744253e-07	0.000863	2
406	ACTR3B_2	0.0000000074	0.00014435842640211195 / 0.0016167318511468814	3.4516372751432266e-05 / 1.6235896245152234e-05	0.000881	2
407	CSRP1_3	0.0000000000	0.0008963909784287442 / 0.0008703935843289303	1.2552190959143249e-05 / 1.0273857961970511e-05	0.000883	2
408	SEPHS1_1	0.0000001827	0.00173044075017522 / 3.679473658399758e-05	8.824502672922857e-06 / 3.0791704702592284e-05	0.000884	2
409	ACTN2_1	0.0000008238	0.0011231690936696782 / 0.0006456808009902826	1.5971362873791044e-06 / 1.6414697658368195e-07	0.000884	2
410	NMRK1_2	0.0000000009	7.927156138657951e-05 / 0.0016947048583457857	1.3825176406826697e-06 / 3.53470906662037e-07	0.000887	2
411	TFAP2A_1	0.0000010622	0.000397182645222389 / 0.001498796467852237	1.6591165825267682e-05 / 3.1676679082128444e-06	0.000948	2
412	CAV1_3	0.0000000000	0.0017923927195771076 / 0.0001624925597934157	1.6411382731391108e-05 / 7.945990872997567e-06	0.000977	2
413	PQLC3_2	0.0000004701	4.389629454841824e-05 / 0.001937287334836558	1.0375195933235037e-08 / 2.8078868409381863e-06	0.000991	2
414	RPL9_4	0.0000000000	3.781374276352481e-05 / 0.002265806028844651	2.8562585574590404e-07 / 1.520546898812959e-06	0.001152	2
415	H2AFY2_3	0.0000000000	0.0023614039163946366 / 5.479642713695821e-06	9.720407948559726e-06 / 2.5274722144655105e-05	0.001183	2
416	MCM10_1	0.0000038124	0.0021610939865988614 / 0.0004600723635955347	1.9111116053257913e-05 / 1.8478236194529347e-06	0.001311	2
417	G6PD_1	0.0000098647	0.0023157697041580965 / 0.0006256240573576323	2.857433835593977e-06 / 2.3724383307219822e-05	0.001471	2
418	TADA1_1	0.0000012097	0.0026490796375761676 / 0.0004052971561229435	3.531944691795736e-06 / 1.881582874926359e-06	0.001527	2
419	KCNC1_5	0.0000000000	1.8731875907040327e-05 / 0.0031223581236072607	7.480602345183493e-06 / 9.900952757251972e-06	0.001571	2
420	JPH4_1	0.0000020704	0.00037839447623271325 / 0.0028279669089626516	1.0663281519153872e-06 / 5.068294298254466e-05	0.001603	2
421	ZNF121_3	0.0000000002	2.4284932942339803e-06 / 0.0032468305940381815	1.097169523033381e-06 / 1.0244293507613468e-05	0.001625	2
422	TMEM206_1	0.0000001917	0.002859168680149655 / 0.0007069744136606002	4.159808093795964e-07 / 7.162200636393188e-06	0.001783	2
423	HS3ST4_1	0.0000030972	0.0027568341257606386 / 0.0008433274564043463	5.152072021912856e-05 / 0.00013189356327001007	0.0018	2
424	MRPL48_1	0.0000003952	0.0037409240031547972 / 1.2412020538304333e-05	0.00010762773346764832 / 5.800656513229227e-07	0.001877	2
425	PPAT_5	0.0000000000	0.0005240883442637788 / 0.0033630327163844836	1.3405009998715396e-07 / 2.0737516222338193e-07	0.001944	2
426	CELF3_3	0.0000000012	2.6606264463249574e-05 / 0.004048158047358375	1.681108063763094e-07 / 6.662779385674438e-06	0.002037	2
427	ABCC8_1	0.0000123268	0.0005728902408745853 / 0.0037587720790259365	2.6233964453337422e-05 / 0.007471621864095462	0.002166	2
428	KIF1C_4	0.0000000003	0.0032619641963901502 / 0.0011569950059438523	8.154868752547337e-07 / 2.557520533005861e-06	0.002209	2
429	MOSPD2_1	0.0000012002	7.763485144629643e-05 / 0.004557941079021841	7.941462431738191e-07 / 1.6722356038590327e-05	0.002318	2
430	ANKRD46_1	0.0000009529	0.0016555906467057811 / 0.0030838618137353662	3.117928478396429e-07 / 1.2106488464901888e-06	0.00237	2
431	RSL24D1_1	0.0000003735	0.0020456136275657888 / 0.002859168680149655	5.740933296039192e-08 / 6.94594888585274e-07	0.002452	2
432	HNRNPC_1	0.0000000442	0.0003168019030192227 / 0.004613449756294485	1.5683726426363387e-05 / 3.1384990249702817e-06	0.002465	2
433	LYST_1	0.0000015802	0.004613449756294485 / 0.0003168019030192227	1.6458786012670833e-07 / 2.821962785745458e-08	0.002465	2
434	MRPS31_2	0.0000000065	0.004772335371973973 / 0.0003355045145354899	3.3355235309279226e-06 / 9.633635724889396e-07	0.002554	2
435	ANXA11_1	0.0000056530	0.005164155170869671 / 0.0004491267996311823	2.916507287390681e-05 / 2.0269807072431288e-06	0.002807	2
436	GABRB3_2	0.0000003351	0.000506059688566897 / 0.005186853257558283	3.096339568332632e-07 / 8.425728705562362e-05	0.002846	2
437	ITGB5_4	0.0000000000	9.326256093187905e-05 / 0.005791631747081949	4.1150806272283625e-06 / 3.579067579944918e-06	0.002942	2
438	TAGLN_5	0.0000000000	0.0016087657150710478 / 0.004695933649935298	1.0747776301357894e-06 / 5.068277336951496e-07	0.003152	2
439	KLF6_1	0.0000063009	0.000825624209859881 / 0.005675752403043091	1.566826366040112e-06 / 2.0575603093756347e-05	0.003251	2
440	GLIS3_1	0.0000001584	0.0019027179320774803 / 0.004613449756294485	8.91146182579548e-08 / 1.1981910549231142e-05	0.003258	2
441	GRPEL2_3	0.0000000000	0.00010726957614676581 / 0.006720367764597034	4.439257342558768e-06 / 8.438825442463246e-05	0.003414	2
442	SORCS1_2	0.0000000000	8.208006168567451e-05 / 0.007038129780933908	7.728334683674074e-07 / 5.209097425595317e-05	0.00356	2
443	TAF3_1	0.0000099483	0.0013546126949011356 / 0.0060782790336966815	1.1902144022027374e-07 / 3.590125727174815e-07	0.003716	2
444	ZNF638_4	0.0000000002	0.004643194113383492 / 0.002879683794588439	1.1731748076272809e-07 / 2.1004419064549084e-06	0.003761	2
445	RPAIN_2	0.0000000089	0.005656902703414097 / 0.0020182027192515075	3.683542119198933e-06 / 5.1931234206185375e-06	0.003838	2
446	PRMT6_2	0.0000000762	4.9232228985570196e-05 / 0.007808321395428832	8.633725399474921e-08 / 1.0594310607660115e-06	0.003929	2
447	CERCAM_1	0.0000000458	0.007033451966587178 / 0.0011697552308872906	2.6140734636276835e-07 / 3.3435498079309047e-05	0.004102	2
448	TWSG1_1	0.0000001761	6.392429369799613e-05 / 0.008158453075892491	5.157744855455523e-08 / 1.1607198631441237e-05	0.004111	2
449	NAP1L1_1	0.0000006251	0.0009903851658940631 / 0.00741156873832107	3.573144437875835e-08 / 2.6755598797458433e-05	0.004201	2
450	NQO2_1	0.0000003120	0.008488814061362355 / 9.017693290134859e-06	2.7731541539595674e-05 / 2.8873360375852757e-06	0.004249	2
451	EXOSC5_1	0.0000025109	0.0004974933526793384 / 0.008173144283430401	7.804789577957665e-13 / 7.74266535906266e-08	0.004335	2
452	LTBP2_1	0.0000549802	0.0001478074168080298 / 0.008876460493888159	0.00010798007651110131 / 4.222343931835182e-06	0.004512	2
453	KIAA1549_3	0.0001342161	0.0026287641054243034 / 0.006519007047359032	7.168411667949609e-07 / 5.5430987684595595e-06	0.004574	2
454	LRP10_2	0.0000001825	0.005921869111264299 / 0.003413606680030668	2.207361096450598e-08 / 3.3470759617279554e-06	0.004668	2
455	CIB1_4	0.0000000168	0.009433179531708233 / 3.3215427791608696e-05	4.2846313000380545e-08 / 3.7292417647649567e-07	0.004733	2
456	RPL19_1	0.0000014928	0.009179325672229992 / 0.00029389877591584477	7.496923788892963e-09 / 2.8239822943662147e-07	0.004737	2
457	CBX2_2	0.0000000000	4.7075406338787466e-05 / 0.00976885548005096	4.131142779946589e-09 / 5.375769141126671e-07	0.004908	2
458	CLVS2_2	0.0000001913	0.009406082212144616 / 0.0006563295421036791	2.5714332068383276e-06 / 5.482716962081155e-06	0.005031	2
459	GLIPR1_2	0.0000000000	3.466171778138515e-05 / 0.010368022895379076	5.654483400792844e-07 / 5.55002977254214e-06	0.005201	2
460	TAPBP_3	0.0000000000	8.512267986732582e-07 / 0.011323761387770928	4.890820513972833e-08 / 6.67431019433855e-06	0.005662	2
461	GNA12_3	0.0000000000	0.001517583413099564 / 0.009900066282835398	6.708969086365922e-07 / 9.569962786694717e-06	0.005709	2
462	MBNL1_1	0.0000001024	0.002859168680149655 / 0.008597087236259153	2.975015241938413e-06 / 0.00015116218032026587	0.005728	2
463	ISYNA1_2	0.0000000015	0.005657495944434386 / 0.006635836004693275	6.464027654347149e-08 / 2.887101958288562e-06	0.006147	2
464	PRLHR_2	0.0000005406	0.007129272200886299 / 0.0052714519884625305	7.77168866368208e-06 / 1.8437240853929896e-05	0.0062	2
465	IQGAP1_5	0.0000000000	0.012455997462084369 / 1.7523681094523592e-05	1.1619283901710663e-08 / 3.139400513751516e-09	0.006237	2
466	SDC4_2	0.0000000000	3.95395916749111e-05 / 0.012655371032190181	4.7350612738275925e-07 / 4.772494328825351e-05	0.006347	2
467	NAA25_1	0.0000047407	0.0004974933526793384 / 0.012491622786737646	8.408015879409482e-10 / 1.1193839755975793e-07	0.006495	2
468	PLEKHA4_1	0.0000000554	0.012681018200430948 / 0.0008147104901488364	4.9420107205779745e-08 / 0.00013683562427249123	0.006748	2
469	TUBA4A_2	0.0000001526	0.0004894051617618149 / 0.013748845190012026	7.439143899721087e-06 / 5.6974125969133664e-05	0.007119	2
470	SLC35D1_1	0.0000119741	0.0011586570434241133 / 0.01344459083967992	7.589908369304536e-05 / 2.286469998615828e-06	0.007302	2
471	SH3GLB1_1	0.0000007167	0.005409509534570436 / 0.00920357999307954	2.215338831755982e-08 / 9.144219102907184e-05	0.007307	2
472	RPL37_1	0.0000002993	0.00029139375190295606 / 0.014437131210731376	1.5481316880518014e-06 / 1.2695577765486368e-06	0.007364	2
473	KDELR3_3	0.0000009988	0.005599828148522198 / 0.009406629582018086	3.321175066033386e-08 / 1.7651037681600008e-10	0.007503	2
474	DDX60L_1	0.0000004277	0.014968932619439228 / 0.00029139375190295606	3.349293334251501e-05 / 3.67192886950216e-06	0.00763	2
475	GNPDA2_1	0.0000009111	0.012345925407573809 / 0.0029871868526872383	1.0139345130923212e-06 / 7.401416660830965e-06	0.007667	2
476	DPY30_1	0.0000001493	0.01474377883043126 / 0.0008872221356225374	8.242352750056853e-06 / 1.0099284699945813e-06	0.007816	2
477	MURC_2	0.0000010524	0.002464237492576691 / 0.013298076855589635	0.00016259523386897824 / 1.28646138088586e-05	0.007881	2
478	CCDC80_2	0.0000000780	0.007022396430063894 / 0.009406629582018086	1.9897144922152364e-08 / 5.96038844248789e-08	0.008215	2
479	C12orf23_1	0.0000007686	0.007054606953047138 / 0.009406629582018086	2.070000126404187e-09 / 3.064830496384329e-08	0.008231	2
480	LOX_1	0.0000004721	0.007054606953047138 / 0.009406629582018086	5.585615326605659e-08 / 2.025993050202001e-07	0.008231	2
481	CEP68_3	0.0000000000	0.014160855902587557 / 0.0025428536177246916	6.659688421576734e-07 / 9.407794731883787e-07	0.008352	2
482	BEND3_1	0.0000004060	0.015529327313804105 / 0.0013546126949011356	1.294856510154241e-07 / 7.843354585243828e-07	0.008442	2
483	RPRD2_3	0.0000001192	0.0042160036963409305 / 0.013951484913323634	3.745187782499438e-06 / 6.105707567166931e-05	0.009084	2
484	ELAVL4_3	0.0000000002	0.006262584938725883 / 0.012965192074116545	1.9990927267649097e-08 / 1.2028673633713268e-05	0.009614	2
485	TRIM21_1	0.0000010287	0.010532112594999697 / 0.00986299981987636	5.27087064977811e-07 / 1.4605266535016458e-05	0.010198	2
486	PRPF40B_1	0.0000427258	0.017494900781073297 / 0.0030164053071970965	1.5471503143081632e-06 / 5.832024795399863e-07	0.010256	2
487	DCLRE1A_1	0.0000061634	0.004458350846430188 / 0.0169361079209336	1.1237015427476724e-07 / 3.0864109406370913e-05	0.010697	2
488	DUSP12_1	0.0000017501	0.0005152101842532016 / 0.020927835765182444	1.3639586195049048e-06 / 3.496306255304265e-05	0.010722	2
489	TFPI_2	0.0000000132	4.6545402569552315e-05 / 0.02149290799813975	4.887360747506771e-06 / 4.0474405834306e-05	0.01077	2
490	MYO1C_2	0.0000000121	0.017895823171364 / 0.006230846374778002	3.081448301668384e-05 / 4.014555294520703e-06	0.012063	2
491	SYDE1_1	0.0000000110	0.00772762240557102 / 0.016780696985377475	1.1653781269953101e-07 / 3.463671891124625e-05	0.012254	2
492	RANBP1_1	0.0000003587	0.007033451966587178 / 0.018278644383879286	1.8768112225438676e-06 / 2.385161536231052e-05	0.012656	2
493	PRAME_3	0.0000000000	0.00027122572057250454 / 0.02549151253917823	7.315372425838117e-07 / 0.0043647330554926495	0.012881	2
494	PNN_1	0.0000004953	0.023632426585188764 / 0.0037180700854572363	1.567862197944385e-05 / 1.9432605539900083e-06	0.013675	2
495	PHF11_3	0.0000000000	0.0199742851386832 / 0.0074443763066621635	2.2460867352749832e-05 / 4.034050219148119e-05	0.013709	2
496	WDR35_1	0.0000956275	0.00595365839866055 / 0.022259394060437563	2.301536456666849e-08 / 4.7905231342002456e-05	0.014107	2
497	KCNN4_5	0.0000000000	0.028325850554739726 / 1.0422333032628909e-05	4.2230909676496135e-06 / 6.214193085118779e-08	0.014168	2
498	SERPINB6_1	0.0000000860	0.02111164899698619 / 0.007725328433277938	2.187431797229529e-06 / 2.509158352753995e-06	0.014418	2
499	ACOT9_5	0.0000000000	8.858145837069308e-06 / 0.02928133094687868	1.4274535341490866e-06 / 1.1707897663572821e-05	0.014645	2
500	LAMP1_2	0.0000000008	0.030054976866849478 / 8.732445306306717e-05	5.466481696938671e-06 / 1.5820496858297314e-06	0.015071	2
501	C19orf10_2	0.0000012073	0.007022396430063894 / 0.02370242637699958	1.3938096456595192e-06 / 3.106836436822797e-06	0.015362	2
502	EHD2_1	0.0000051889	0.006387086743044337 / 0.024359073362915318	3.1581541925072244e-08 / 6.252023917064675e-07	0.015373	2
503	DPH5_1	0.0000000253	0.005268014147815726 / 0.025798539904455884	7.65363618891567e-06 / 2.5443259723878794e-07	0.015533	2
504	TMEM169_1	0.0000042184	0.015328857071669418 / 0.01613036709497828	5.271735025959501e-06 / 7.657861944466996e-06	0.01573	2
505	SMARCB1_1	0.0000002644	0.02077959376727299 / 0.011174729900658115	8.011755580473669e-08 / 3.2615951234563365e-06	0.015977	2
506	PLEKHF2_1	0.0000084591	0.030555512760793904 / 0.0019120019643383967	6.139203454059454e-06 / 1.7597453128430795e-05	0.016234	2
507	HSF2_5	0.0000000024	0.0011883468549077506 / 0.032054869676694284	3.40227203271683e-05 / 0.00014757007119292403	0.016622	2
508	ASPH_1	0.0000002995	0.033538144332397844 / 0.00028614552404424633	5.685936788307393e-09 / 9.429685991450496e-08	0.016912	2
509	SERINC3_1	0.0000008790	0.033538144332397844 / 0.00028614552404424633	2.49764511508294e-09 / 1.134358362342082e-07	0.016912	2
510	THOC5_1	0.0000003036	0.013135303284974763 / 0.02077959376727299	2.342665333258182e-05 / 2.6803490912759556e-06	0.016957	2
511	SLC6A15_1	0.0000005833	0.004726766888964287 / 0.029245906890336886	3.0205657665658226e-07 / 1.9753690366539358e-07	0.016986	2
512	TBC1D2_1	0.0000051878	0.0026971498523362084 / 0.03142306493318558	2.36394903321324e-07 / 3.4669139065625866e-06	0.01706	2
513	HSPG2_1	0.0000035348	0.005508211750735854 / 0.029004639226340192	3.456379747077034e-08 / 1.3650260422668218e-06	0.017256	2
514	CACNA2D2_1	0.0000002397	0.012989035651382866 / 0.0220527090420233	9.84795387151116e-07 / 0.00014763731434387815	0.017521	2
515	SLC5A6_2	0.0000000011	6.726351690377188e-06 / 0.03632726905839838	3.564147772687014e-09 / 2.3833706506813445e-08	0.018167	2
516	DAZAP1_2	0.0000010886	0.035346052334371256 / 0.0020041144974840427	6.336641396851863e-06 / 2.7162116297049073e-06	0.018675	2
517	NFIX_2	0.0000470223	0.034278763403653136 / 0.004363119893312578	3.742274946692005e-08 / 8.621152000254767e-06	0.019321	2
518	ELAVL3_3	0.0000002367	0.032717168309564344 / 0.00603260340463039	5.233156358088248e-08 / 1.2259141243737108e-05	0.019375	2
519	COPB2_1	0.0000009988	0.030556265901493518 / 0.009461453275903385	7.7726596868819e-09 / 1.2483359571678263e-07	0.020009	2
520	ZNF219_1	0.0000201928	0.0013753510178836541 / 0.040351165135619635	4.130137554486895e-08 / 8.551025528226429e-06	0.020863	2
521	RNF165_2	0.0000000071	0.00045689445671322015 / 0.04290525645291146	4.007091987107082e-07 / 5.771520423008575e-06	0.021681	2
522	P4HA1_1	0.0000001230	0.03388354547402121 / 0.009805971532350915	0.0006317756731189806 / 1.426894913839978e-05	0.021845	2
523	CIB2_3	0.0000052976	0.03149060869705135 / 0.012259451329060318	9.024424890774902e-07 / 1.0442027429124592e-07	0.021875	2
524	LMAN2_1	0.0000170444	0.01903033340546255 / 0.025082579510674555	7.009613011978967e-07 / 2.5751189172533023e-06	0.022056	2
525	POFUT1_1	0.0000072701	0.001142587490178054 / 0.043241971329782115	7.112620349907573e-07 / 1.1322431164545276e-05	0.022192	2
526	ITGB1_1	0.0000003907	0.02269898054008244 / 0.0248532779265148	7.3505722166603895e-09 / 1.5385068037778083e-08	0.023776	2
527	GFPT2_2	0.0000000000	0.04814570015405706 / 9.938212812133593e-06	1.3739713879197712e-06 / 1.5888765178369776e-06	0.024078	2
528	SNTB2_2	0.0000013898	0.00045763370789409137 / 0.04798455655539519	4.937390910049744e-08 / 1.0481483686547674e-06	0.024221	2
529	FAM126A_1	0.0000076004	0.008114330308262623 / 0.043466125038867966	6.442446565574853e-07 / 7.404414626788326e-07	0.02579	2
530	FAM214B_1	0.0000010912	0.007767111012470563 / 0.04394971982153738	9.766150972459384e-09 / 5.811940190116354e-06	0.025858	2
531	E2F5_1	0.0000013604	0.049711930848541044 / 0.0033175174072552346	4.003267630664399e-07 / 9.866737749751602e-07	0.026515	2
532	CRMP1_1	0.0000084591	0.017443397981769932 / 0.03683753470884825	8.413742944743679e-07 / 4.106621117381678e-06	0.02714	2
533	DTX3L_1	0.0000084583	0.03683753470884825 / 0.017443397981769932	6.797147151581183e-07 / 1.417692420229351e-07	0.02714	2
534	ELAVL3_1	0.0000001607	0.03683753470884825 / 0.017443397981769932	1.3771030020123217e-07 / 1.1898412039254247e-06	0.02714	2
535	GATA2_1	0.0000032251	0.017443397981769932 / 0.03683753470884825	2.379056852862588e-07 / 7.419739232422929e-07	0.02714	2
536	GNG4_1	0.0000011175	0.017443397981769932 / 0.03683753470884825	2.833288980358075e-07 / 3.0194192839021757e-06	0.02714	2
537	GPX8_1	0.0000018792	0.017443397981769932 / 0.03683753470884825	1.1126780547850324e-07 / 3.7460365163269813e-07	0.02714	2
538	LATS2_1	0.0000002146	0.017443397981769932 / 0.03683753470884825	8.009574761254957e-07 / 7.564366651535585e-06	0.02714	2
539	TMEM87B_1	0.0000035381	0.046460374349346606 / 0.00986299981987636	2.2083608853369944e-06 / 2.6000415048116556e-06	0.028162	2
540	NR2C1_1	0.0000011174	0.049070601469191656 / 0.00773983756525658	1.016347019186649e-05 / 2.9570254790683987e-05	0.028405	2
541	CHMP4B_1	0.0000228401	0.023755415081211387 / 0.03496487724871062	7.568402263460558e-06 / 1.602695870510606e-06	0.02936	2
542	HPDL_1	0.0000326628	0.04277794935005184 / 0.01886546643390927	2.946919779060583e-07 / 2.526544471155658e-06	0.030822	2
543	HNRPDL_1	0.0000017461	0.029245906890336886 / 0.03496385796284249	5.094906510060717e-06 / 0.0005450663768553773	0.032105	2
544	MICB_1	0.0000005886	0.03856382315007413 / 0.030649533557856844	3.2225183304348016e-07 / 2.082657792499939e-05	0.034607	2
545	C17orf53_5	0.0056512849	0.03313812387988766 / 0.0369823965122664	1.7766971737416816e-07 / 4.945807676396787e-08	0.03506	2
546	WDR3_1	0.0000063135	0.038526552055961574 / 0.033508173499253606	1.3194741430704085e-06 / 5.999026130299875e-08	0.036017	2
547	FKBP15_1	0.0000015165	0.038665976753680685 / 0.037764618743349666	1.938771779561528e-07 / 8.867393316201706e-07	0.038215	2
548	SLC22A23_1	0.0000002831	8.712601577854501e-09	1.4395456175321122e-06	8.71E-09	One
549	ST6GALNAC3_1	0.0000002679	8.712601577854501e-09	1.7157900523441861e-07	8.71E-09	One
550	RCAN1_3	0.0000000016	3.499510929936492e-08	1.26835830581151e-07	3.5E-08	One
551	CCDC107_2	0.0000000001	6.395893878746714e-08	9.461935060607236e-07	6.4E-08	One
552	PAX6_2	0.0000000009	7.077258149360326e-07	9.972664897230697e-08	7.08E-07	One
553	IGSF9_5	0.0000000004	1.1979104163692412e-06	8.265188982147678e-06	1.2E-06	One
554	TFAP4_2	0.0000000085	2.321730111153503e-06	1.7564281952911052e-07	2.32E-06	One
555	B2M_5	0.0000000000	2.8861862169068284e-06	4.480381749486679e-06	2.89E-06	One
556	ZCCHC12_1	0.0000002526	3.027796588478565e-06	3.463674540195252e-08	3.03E-06	One
557	MYL12B_3	0.0000000860	3.036941140125125e-06	1.4602780290417217e-05	3.04E-06	One
558	SHPRH_5	0.0000000003	5.230619502812216e-06	2.937677082211747e-07	5.23E-06	One
559	NRSN1_4	0.0000000000	5.476196107524447e-06	2.997579133447394e-06	5.48E-06	One
560	HNRNPR_3	0.0000000000	5.558921390245165e-06	3.126649204411196e-06	5.56E-06	One
561	RRAGC_2	0.0000000001	5.618452957713235e-06	9.311046175034272e-06	5.62E-06	One
562	CTSA_3	0.0000000013	6.56608104779876e-06	2.506639438406534e-09	6.57E-06	One
563	DUSP26_3	0.0000000000	7.058822532691102e-06	4.827489564324781e-06	7.06E-06	One
564	IFI35_2	0.0000000001	7.334382821279422e-06	3.030479316814345e-07	7.33E-06	One
565	FAM163A_4	0.0000000000	9.356029087940393e-06	1.1664211635226015e-06	9.36E-06	One
566	DHX15_3	0.0000000002	9.568251410073365e-06	2.403428814770779e-07	9.57E-06	One
567	WDR86_3	0.0000000000	1.0462572531149967e-05	5.73499996685614e-06	1.05E-05	One
568	CECR5_1	0.0000003529	1.2412020538304333e-05	8.265652927676646e-07	1.24E-05	One
569	VASH2_1	0.0000000292	1.2412020538304333e-05	2.7260938912368544e-09	1.24E-05	One
570	KCNH8_2	0.0000000001	1.3893428326375037e-05	1.025651613746495e-06	1.39E-05	One
571	MRPS25_3	0.0000000000	1.4962982992013249e-05	5.883502199500679e-05	1.5E-05	One
572	COPS7B_4	0.0000000000	1.9055379659727616e-05	1.8406897134601384e-06	1.91E-05	One
573	PHYHIPL_2	0.0000000044	1.9765992682251932e-05	7.662073328952884e-08	1.98E-05	One
574	ATP6V0E1_3	0.0000000000	2.1199783161506686e-05	3.178350125115292e-06	2.12E-05	One
575	CEP44_5	0.0000000000	2.6817088180208884e-05	3.075797968981328e-07	2.68E-05	One
576	SEC22C_1	0.0000126263	3.772462305351297e-05	2.5473717020986836e-06	3.77E-05	One
577	TRIM38_2	0.0000000010	4.232307256197528e-05	9.004771302620853e-07	4.23E-05	One
578	MTF2_1	0.0000003729	4.778480179883678e-05	3.677618476819043e-06	4.78E-05	One
579	ZC3H15_4	0.0000000000	4.99139389651813e-05	8.062168588983905e-05	4.99E-05	One
580	THOC5_2	0.0000000078	5.370663550005663e-05	9.265177499664469e-07	5.37E-05	One
581	CLASP2_2	0.0000000009	5.412804644102036e-05	3.7830870595223054e-07	5.41E-05	One
582	SLC18A2_2	0.0000000045	5.6390218253045825e-05	1.7279928388791176e-05	5.64E-05	One
583	NDUFAF4_4	0.0000000000	5.8700155983793994e-05	2.5189349324309824e-08	5.87E-05	One
584	CHD4_1	0.0000002613	6.392429369799613e-05	4.5917357478734616e-10	6.39E-05	One
585	KIF5A_3	0.0000000388	6.823910763393263e-05	2.8021219460869213e-07	6.82E-05	One
586	CNN2_2	0.0000000049	7.667846295453872e-05	4.936771116007079e-06	7.67E-05	One
587	DCBLD1_2	0.0000000000	7.734573702217467e-05	2.622737549604328e-07	7.73E-05	One
588	SPSB4_2	0.0000000009	7.736803917574157e-05	1.665549189503519e-06	7.74E-05	One
589	EDIL3_1	0.0000003533	7.763485144629643e-05	2.106653942117265e-06	7.76E-05	One
590	GALNT10_3	0.0000000000	8.677918268232137e-05	8.482412543283543e-07	8.68E-05	One
591	H1FX_1	0.0000006013	9.000996792266372e-05	3.1636024561990265e-07	9E-05	One
592	OSGIN1_4	0.0000001415	9.283230157343638e-05	1.9657683205901488e-07	9.28E-05	One
593	PRRX1_1	0.0000004579	9.464090281065672e-05	3.3589212783746634e-09	9.46E-05	One
594	SERF2_1	0.0000008582	9.559019073817654e-05	3.4428228168417093e-07	9.56E-05	One
595	PPP1CC_3	0.0000000001	9.749181327114085e-05	1.7389165234639967e-07	9.75E-05	One
596	SYDE1_2	0.0000000598	0.00010643560926875712	1.503089017990499e-07	0.000106	One
597	C11orf74_2	0.0000000007	0.00010744642656817331	1.4631867053999944e-05	0.000107	One
598	NEFH_1	0.0000000473	0.00011095297992729127	1.5371136619548915e-05	0.000111	One
599	MPPE1_2	0.0000000746	0.00011144654065968228	1.6486688003824867e-06	0.000111	One
600	RAC3_1	0.0000011018	0.00012418009082273935	4.416840433956102e-05	0.000124	One
601	XRCC2_1	0.0000063155	0.0001281986995674009	2.3117725678541128e-08	0.000128	One
602	PVRL2_2	0.0000000002	0.00013157696997892983	1.9665782290909765e-07	0.000132	One
603	JAKMIP1_3	0.0000000000	0.0001624284911175795	1.3322851721010925e-05	0.000162	One
604	RETSAT_2	0.0000000021	0.00018285567959994966	2.2405276167100574e-05	0.000183	One
605	ECSIT_4	0.0000000000	0.00023954975788706846	7.566489045169451e-08	0.00024	One
606	KCTD11_5	0.0000000000	0.0002424331083574083	3.522356648205783e-06	0.000242	One
607	NOL4_1	0.0000000729	0.0002459835698877307	6.791821030730467e-07	0.000246	One
608	PHACTR3_1	0.0000000457	0.0002459835698877307	0.00011686809560116665	0.000246	One
609	RTN1_1	0.0000006098	0.0002459835698877307	4.222711647559608e-07	0.000246	One
610	STMN2_1	0.0000012964	0.0002459835698877307	4.094884978838306e-05	0.000246	One
611	AP2S1_2	0.0000000002	0.0002471622654017496	1.0198622949899072e-05	0.000247	One
612	ZFYVE21_1	0.0000194549	0.00025234279143195943	5.133817635619759e-06	0.000252	One
613	UNC13A_1	0.0000014726	0.00028614552404424633	2.0145584910723037e-05	0.000286	One
614	HRH3_2	0.0000000245	0.00028947620258979817	6.225133521987448e-05	0.000289	One
615	SLC46A3_1	0.0000004395	0.00029139375190295606	3.1273990762894294e-06	0.000291	One
616	FANCF_1	0.0000011239	0.00029389877591584477	0.00014597857403495873	0.000294	One
617	NUP188_1	0.0000001812	0.0003007412862887539	4.955407744532583e-06	0.000301	One
618	RASL11B_4	0.0000000000	0.00031499165163320023	4.227422993905127e-06	0.000315	One
619	RPL35A_1	0.0000009189	0.0003258993441790789	7.814046683768043e-08	0.000326	One
620	MRPS34_2	0.0000000002	0.0003472766416957016	2.882909993280601e-07	0.000347	One
621	GIMAP2_3	0.0000000036	0.0003570706360030332	0.00045579260491531034	0.000357	One
622	CEP290_2	0.0000000344	0.00037108570224806444	2.0125145944135785e-07	0.000371	One
623	GLTPD1_2	0.0000000118	0.0003718951957804949	0.0006320584367733676	0.000372	One
624	GPHN_2	0.0000000007	0.0003773923191660758	5.22047699300538e-06	0.000377	One
625	CASP1_1	0.0000000068	0.00037839447623271325	6.1495186991073225e-09	0.000378	One
626	ZNF696_1	0.0000000962	0.00037839447623271325	2.4615255354876653e-06	0.000378	One
627	PUM2_1	0.0000026305	0.0003816779304374477	3.3222971313684545e-07	0.000382	One
628	MEIS1_3	0.0000004107	0.0003904462676161654	0.0007682186961292422	0.00039	One
629	IFI30_1	0.0000012163	0.00040506375286474184	9.574423734042937e-07	0.000405	One
630	IL11RA_1	0.0000001170	0.0004052971561229435	2.655673357753088e-06	0.000405	One
631	NUCB2_1	0.0000013611	0.0004052971561229435	5.5618984098014e-07	0.000405	One
632	PTP4A3_1	0.0000000680	0.0004052971561229435	5.887768664427049e-08	0.000405	One
633	ADRBK2_2	0.0000000000	0.0004093391300622974	1.5783568509062198e-06	0.000409	One
634	PKIG_3	0.0000000000	0.00041171580743841403	3.057193996659834e-08	0.000412	One
635	SET_2	0.0000000001	0.0004229662691805196	1.4462314562288453e-05	0.000423	One
636	FLII_4	0.0000000000	0.000424309729157916	2.721972050662147e-05	0.000424	One
637	ARF6_1	0.0000010688	0.00044644151159829265	4.777162467883633e-05	0.000446	One
638	HMGCR_1	0.0000039108	0.0004491267996311823	9.51430189572535e-06	0.000449	One
639	ST8SIA3_1	0.0000019568	0.0004491267996311823	4.900547697748023e-06	0.000449	One
640	UNC80_1	0.0000008226	0.0004491267996311823	1.005782022353512e-07	0.000449	One
641	CCT8_3	0.0000000347	0.00045011610035894004	2.032003598923382e-06	0.00045	One
642	TRIM28_1	0.0000148486	0.00045014028192995044	3.949110489775901e-06	0.00045	One
643	CDC25A_2	0.0000000098	0.0004534776514099725	1.5512971032931264e-06	0.000453	One
644	GLTP_2	0.0000000028	0.00046494643788992516	5.8185552156116945e-06	0.000465	One
645	CCDC77_1	0.0000004612	0.0004974933526793384	4.507699749268401e-07	0.000497	One
646	MCF2L_1	0.0000000690	0.0005027123562350216	7.202072224189724e-07	0.000503	One
647	SLC6A2_2	0.0000001185	0.000506059688566897	2.28692972901338e-08	0.000506	One
648	SYP_2	0.0000001356	0.000506059688566897	6.3185873271940225e-06	0.000506	One
649	CNOT6_1	0.0000013898	0.0005152101842532016	1.3714419618221151e-06	0.000515	One
650	VARS_1	0.0000000157	0.0005152101842532016	6.389630116189804e-11	0.000515	One
651	IFITM3_4	0.0000000000	0.0005174358092289639	1.9647037009697173e-05	0.000517	One
652	PEX5_1	0.0000022882	0.0005345944155461007	2.4708316986247094e-07	0.000535	One
653	SLC31A2_2	0.0000000257	0.0005474521677410701	1.2568064895404654e-06	0.000547	One
654	GRIK3_1	0.0000076075	0.0005728902408745853	5.005291812592071e-05	0.000573	One
655	VN1R1_1	0.0000028939	0.0006456808009902826	1.5945573929220053e-06	0.000646	One
656	TFB2M_1	0.0000001636	0.0006554884190714251	8.29128842666871e-07	0.000655	One
657	MAD2L1_1	0.0000002657	0.000678865345560909	0.00022984708856661868	0.000679	One
658	MCM7_1	0.0000003921	0.000678865345560909	2.3157502863099238e-08	0.000679	One
659	MLF1IP_1	0.0000001155	0.000678865345560909	1.6356325391481808e-06	0.000679	One
660	RFC3_1	0.0000001961	0.000678865345560909	1.1405622586556333e-05	0.000679	One
661	RPL13A_5	0.0000000036	0.0006975780500730752	2.039076211055246e-07	0.000698	One
662	LINGO2_5	0.0000000000	0.0007331284191550658	3.7702692631153038e-06	0.000733	One
663	DNAJC22_1	0.0000621331	0.0007382242549827655	0.000384678461175607	0.000738	One
664	LAPTM4B_5	0.0000000199	0.0008008831004583888	1.799793994988323e-08	0.000801	One
665	MRPL21_1	0.0000002469	0.000813643911578377	2.155726402205982e-11	0.000814	One
666	KBTBD6_5	0.0000000012	0.0008752905126922217	5.094541684026646e-07	0.000875	One
667	ENDOD1_1	0.0000010618	0.0009656194251740187	1.0198902416156784e-06	0.000966	One
668	DYNLT3_1	0.0000002295	0.0009791477447292118	3.4005766399654322e-06	0.000979	One
669	FBXO33_3	0.0000001392	0.00103117959256628	0.0005017044994385344	0.001031	One
670	MAGT1_3	0.0000000006	0.0011183473761450665	3.282773317248208e-06	0.001118	One
671	RAP2C_1	0.0000000589	0.0012216917856767418	2.1738080076458742e-06	0.001222	One
672	UNC13A_4	0.0000000000	0.0012433758358174857	1.4243994675867104e-05	0.001243	One
673	MFAP5_1	0.0000031279	0.0012466841325621532	3.1380128368492257e-06	0.001247	One
674	CUX2_2	0.0000000011	0.001257136009743649	7.431311834991675e-07	0.001257	One
675	MED25_5	0.0000000204	0.001313200027316744	1.4936727700519996e-05	0.001313	One
676	MYT1L_2	0.0000000108	0.0013890971495074075	1.0025847658579697e-06	0.001389	One
677	TMEM18_2	0.0000076695	0.0013942235684900853	1.707287632066412e-07	0.001394	One
678	CCT7_1	0.0000001734	0.001443320215490813	1.1968773859770425e-09	0.001443	One
679	MAK16_1	0.0000004814	0.001443320215490813	2.3072064933343512e-09	0.001443	One
680	MRPS21_1	0.0000000540	0.001443320215490813	6.719016265932361e-09	0.001443	One
681	POLR1B_1	0.0000003351	0.001443320215490813	1.7793565095841775e-08	0.001443	One
682	GTPBP1_2	0.0000000021	0.001459680524809358	0.00015614452037923833	0.00146	One
683	EBF3_1	0.0000010072	0.0014691176249919573	8.044891819455788e-07	0.001469	One
684	MTUS1_2	0.0000935307	0.0015509534579936969	1.105438193098732e-06	0.001551	One
685	NUP133_2	0.0000000014	0.0015899100236963135	1.3303993388626396e-05	0.00159	One
686	CTNND1_2	0.0000000000	0.001732526914901912	3.072309330628804e-05	0.001733	One
687	NDUFB9_1	0.0000000238	0.0017523496068642189	5.3915212453729005e-09	0.001752	One
688	SLC9A7_1	0.0000003133	0.0017523496068642189	1.2535099503914342e-05	0.001752	One
689	EIF4ENIF1_1	0.0000108333	0.0017678348648425643	3.7197697739906752e-06	0.001768	One
690	DOCK1_1	0.0000181948	0.001772102755233229	1.4070332453720584e-06	0.001772	One
691	RPL32_1	0.0000022322	0.001777378099890663	6.225050246986396e-05	0.001777	One
692	PRICKLE2_1	0.0000006847	0.0018473350729729212	2.0385221521213067e-05	0.001847	One
693	RUFY3_1	0.0000070188	0.0018473350729729212	1.8701260489318547e-05	0.001847	One
694	WNT5A_1	0.0000028497	0.0018473350729729212	2.708727992064078e-06	0.001847	One
695	MPHOSPH10_2	0.0000000007	0.0018678908445817427	1.5239795553355398e-06	0.001868	One
696	ARID3A_1	0.0000002399	0.0019027179320774803	5.715891598653691e-07	0.001903	One
697	HBQ1_1	0.0000006406	0.0019027179320774803	6.157621558231056e-07	0.001903	One
698	CAPG_5	0.0000000000	0.001947090513575717	7.749723393890698e-06	0.001947	One
699	YARS2_2	0.0005979379	0.0019907006334396776	5.679834094373692e-07	0.001991	One
700	KIAA0247_5	0.0000000008	0.001994915026343904	7.399520670189372e-07	0.001995	One
701	ATP6V1A_1	0.0000002721	0.0020456136275657888	5.629476223876873e-08	0.002046	One
702	NFXL1_3	0.0000000000	0.0020758764777589786	5.099976094773998e-07	0.002076	One
703	RIOK3_3	0.0000000003	0.0021500812901470065	0.00030023156807518783	0.00215	One
704	AKR7A2_4	0.0000000023	0.0021553658383185563	2.358890665005359e-05	0.002155	One
705	THOC1_3	0.0000009047	0.002194182322111777	0.00021664763805975321	0.002194	One
706	COPG_1	0.0000003427	0.0021961385175434875	8.880302868410324e-08	0.002196	One
707	RPL13_1	0.0000004776	0.002391299161389133	4.361906742412738e-06	0.002391	One
708	ARRB2_2	0.0000000003	0.0024223436617129856	8.170313945294133e-05	0.002422	One
709	CCDC41_2	0.0000005081	0.0024621645703630526	1.7620046187445725e-05	0.002462	One
710	WDR75_5	0.0000000001	0.0024742390938208743	2.813266963497791e-07	0.002474	One
711	LRBA_4	0.0000000000	0.002519709257235862	0.0002137598179932144	0.00252	One
712	BAI3_2	0.0000000007	0.002579529817958645	3.1862597515464765e-08	0.00258	One
713	FKBP4_1	0.0000009273	0.0026665845796536394	3.954836683246733e-07	0.002667	One
714	H3F3B_1	0.0000006090	0.0026665845796536394	1.0621184124507563e-07	0.002667	One
715	LRRC45_1	0.0000035848	0.002695070404947365	0.005476743217592932	0.002695	One
716	VPRBP_1	0.0000098159	0.0028451265399304145	0.00033046637508825843	0.002845	One
717	KIF1A_1	0.0000002287	0.002859168680149655	7.313472575923523e-07	0.002859	One
718	RPL3_1	0.0001386435	0.0028919508671728217	4.887776236374372e-07	0.002892	One
719	ABI3BP_1	0.0000085821	0.003065043011644369	1.0951385360313097e-07	0.003065	One
720	FBRSL1_1	0.0000038191	0.0030838618137353662	2.4058708516257493e-06	0.003084	One
721	RAB3C_1	0.0000001743	0.0030838618137353662	2.7538671921394696e-07	0.003084	One
722	C16orf59_1	0.0000000275	0.0031574556401693433	1.5986180058945153e-05	0.003157	One
723	NUP35_1	0.0000004963	0.0031574556401693433	1.514239152011962e-06	0.003157	One
724	LPIN2_1	0.0000098827	0.0034466689399791843	2.452952119077932e-06	0.003447	One
725	ZNF507_2	0.0000000111	0.003820596558681088	0.00011453249175240676	0.003821	One
726	ADAM10_1	0.0000233014	0.0038798255226726924	6.64776252928381e-06	0.00388	One
727	FBXL18_1	0.0000066755	0.0038798255226726924	7.005071001453964e-05	0.00388	One
728	TMOD3_1	0.0000078430	0.0038798255226726924	1.2077163895524178e-08	0.00388	One
729	HLCS_3	0.0000000014	0.003897587461379324	6.778958570865246e-05	0.003898	One
730	NYNRIN_1	0.0000000051	0.0040253432504568695	5.327811563265487e-06	0.004025	One
731	PDXK_1	0.0000012454	0.0041233566091711665	6.342148817937973e-09	0.004123	One
732	RPS11_3	0.0000000443	0.0043239457542860625	1.7167121527934926e-08	0.004324	One
733	LCE2B_1	0.0000000888	0.004326577770871151	8.013095879242094e-06	0.004327	One
734	MAP2K7_3	0.0000000490	0.004508166201072404	3.487700085903893e-07	0.004508	One
735	PATZ1_1	0.0000004164	0.004557941079021841	3.004553790169959e-08	0.004558	One
736	SMCR7L_1	0.0000000162	0.004557941079021841	1.0835431093170762e-07	0.004558	One
737	CNTNAP2_1	0.0000001099	0.004613449756294485	2.310283526460759e-05	0.004613	One
738	SLC29A3_1	0.0000003134	0.004613449756294485	4.496266117362092e-06	0.004613	One
739	ZBTB34_1	0.0000040446	0.004618680063226724	8.498577839821885e-07	0.004619	One
740	PRKAA1_2	0.0000001321	0.004627796941857709	5.55517925893019e-06	0.004628	One
741	IRF1_2	0.0000000003	0.004777571752988573	6.77745840075317e-08	0.004778	One
742	GDAP1L1_5	0.0000000002	0.004808546917289599	1.5091907669172042e-06	0.004809	One
743	NUP205_2	0.0000009871	0.004863314597556403	0.0012109741287245038	0.004863	One
744	NUS1_1	0.0000000240	0.005366950975922179	3.380290864221785e-05	0.005367	One
745	GOLT1B_3	0.0000022695	0.005599828148522198	3.3515801939710514e-08	0.0056	One
746	SEC24A_2	0.0000000249	0.005701481885121388	7.068590877915707e-08	0.005701	One
747	AVEN_1	0.0000004065	0.005953586357194907	1.3650737340980481e-05	0.005954	One
748	BRD3_1	0.0000002324	0.0060047412034100744	7.118719879444557e-05	0.006005	One
749	CBX5_1	0.0000008271	0.0060047412034100744	2.073650192477865e-07	0.006005	One
750	ZNF689_1	0.0000000501	0.006037283839286274	8.7110715845335e-07	0.006037	One
751	RHOG_5	0.0000003561	0.006148753448353471	4.9151555577284784e-05	0.006149	One
752	SPRY1_4	0.0000003345	0.006174801125444205	0.0033247321236384107	0.006175	One
753	NR1H2_2	0.0000000004	0.006201080908802092	7.565957176888148e-05	0.006201	One
754	RTKN2_1	0.0000066891	0.006287821872432228	2.618709167085205e-06	0.006288	One
755	CHRNA5_1	0.0000056104	0.006387086743044337	1.5554788280693852e-06	0.006387	One
756	PEBP1_1	0.0000011028	0.006389356754277303	3.377019522860942e-08	0.006389	One
757	CNOT6_1	0.0000000995	0.0064218708869592965	1.2731573046468182e-07	0.006422	One
758	FEM1B_1	0.0000014595	0.006512658184422679	1.2419959836180664e-05	0.006513	One
759	PDCD2L_1	0.0000198400	0.006732981542919481	7.754024385726151e-07	0.006733	One
760	BCCIP_2	0.0000000036	0.006993057619665846	1.8570072163956842e-07	0.006993	One
761	C17orf80_2	0.0000003489	0.007022396430063894	9.534705566156907e-06	0.007022	One
762	TMEM229A_1	0.0000014642	0.007033451966587178	4.488027198291259e-06	0.007033	One
763	AKAP1_1	0.0000048789	0.007054606953047138	2.2520683380861938e-08	0.007055	One
764	EPC2_1	0.0000187282	0.007054606953047138	3.1361338152693263e-06	0.007055	One
765	FKBP14_1	0.0000001541	0.007054606953047138	5.2000405163879345e-08	0.007055	One
766	HMGB1_1	0.0000243369	0.007054606953047138	3.5582530664664353e-06	0.007055	One
767	TMEM167B_1	0.0000089984	0.007054606953047138	4.903843719615824e-08	0.007055	One
768	FURIN_1	0.0000013583	0.007154235078360664	0.0024498354764936592	0.007154	One
769	FUZ_2	0.0000000010	0.007484149048900862	8.06345585283052e-07	0.007484	One
770	RAX_1	0.0000005607	0.007849325275374927	1.5165025207033165e-06	0.007849	One
771	HSPA5_1	0.0000233798	0.00804650712219702	3.3345569936160264e-07	0.008047	One
772	SEZ6_1	0.0000001552	0.00809133905523077	2.1206134094154278e-05	0.008091	One
773	CDC7_2	0.0000090196	0.00818484412008511	5.21476362116686e-05	0.008185	One
774	TIMELESS_2	0.0000000005	0.008348387787825583	1.1506564136074267e-05	0.008348	One
775	FAIM2_1	0.0000004595	0.008633031029057705	7.868329291267168e-08	0.008633	One
776	PKIA_1	0.0000117746	0.008813705248904322	1.6109769990275906e-08	0.008814	One
777	MRFAP1L1_1	0.0000000173	0.009220967328515883	2.2849973360661935e-07	0.009221	One
778	SLC4A8_1	0.0000432316	0.010311927011747773	2.2746479512952496e-06	0.010312	One
779	SAMM50_1	0.0000040988	0.010582443118030336	5.607191574381122e-07	0.010582	One
780	FAM129A_1	0.0000110292	0.010610163045225487	0.00021553454881793465	0.01061	One
781	AFMID_5	0.0000000000	0.011037504835486236	6.903237042102531e-06	0.011038	One
782	STARD7_1	0.0000008193	0.011230798403991177	1.4750425191704724e-06	0.011231	One
783	GPN2_2	0.0000000003	0.011286646172223367	0.0002020338349948365	0.011287	One
784	PCDH9_1	0.0000115514	0.01159836162693171	2.5431326048421465e-05	0.011598	One
785	DDOST_2	0.0000006862	0.011732466260948907	7.712332840561586e-07	0.011732	One
786	TMEM109_3	0.0000000174	0.01179210198130457	1.34476580166563e-05	0.011792	One
787	OLA1_2	0.0000001004	0.01186517030330062	3.4419370304963574e-06	0.011865	One
788	RGS3_4	0.0000000707	0.012273010269850448	8.926332727725615e-07	0.012273	One
789	HMGCL_1	0.0000057648	0.013135841653707197	6.151145606016247e-07	0.013136	One
790	SIPA1L1_1	0.0000004161	0.013135841653707197	1.518269230551228e-06	0.013136	One
791	TMEM50A_1	0.0000006936	0.013135841653707197	2.3186309995661696e-05	0.013136	One
792	AP2S1_2	0.0005534120	0.013321879037458757	2.1009217572593065e-05	0.013322	One
793	NARF_1	0.0000001706	0.01356093601279795	7.558805657306656e-07	0.013561	One
794	S100A2_2	0.0000000045	0.013795138693676535	0.0009724391668072714	0.013795	One
795	STX8_2	0.0010456927	0.013842934358702711	6.244242975666368e-07	0.013843	One
796	SLC10A4_3	0.0000000008	0.0147620266284032	0.00012936185099713163	0.014762	One
797	KCNAB1_1	0.0000177047	0.014856183619266723	1.5321385429315337e-05	0.014856	One
798	NUFIP1_1	0.0000040928	0.015328857071669418	1.4820509456787599e-05	0.015329	One
799	PUS7_1	0.0002258870	0.015382714940475899	0.0003699975490667046	0.015383	One
800	TMEM33_1	0.0000021939	0.015382714940475899	7.8917032520098e-05	0.015383	One
801	SUPT4H1_1	0.0000076733	0.015545833082593517	3.111378512146274e-05	0.015546	One
802	B4GALT1_2	0.0000000036	0.015866838196212218	4.984509522594122e-08	0.015867	One
803	TRMT1_1	0.0000002555	0.016113877031426083	3.5979546226837025e-05	0.016114	One
804	ITCH_1	0.0000006285	0.016311084928625978	3.67059506817032e-06	0.016311	One
805	SLC41A2_1	0.0000027434	0.016829575684385905	0.0002722352435422239	0.01683	One
806	UBXN1_1	0.0000006760	0.01695446499444467	2.7446548902174226e-06	0.016954	One
807	AARS2_1	0.0000130548	0.017241329872294712	5.7037625716450966e-05	0.017241	One
808	ASB13_1	0.0000238679	0.017330336075027382	4.6209737153601604e-07	0.01733	One
809	CSDA_1	0.0000009251	0.017443397981769932	0.0011464157798244399	0.017443	One
810	DBH_1	0.0000079113	0.017443397981769932	1.4347684455753113e-06	0.017443	One
811	DOK4_1	0.0000231034	0.017443397981769932	6.618729332114159e-06	0.017443	One
812	FAM57B_1	0.0000016227	0.017443397981769932	5.886088725233178e-06	0.017443	One
813	GRIA4_1	0.0000003095	0.017443397981769932	2.302309309599117e-05	0.017443	One
814	IGFBPL1_1	0.0000008576	0.017443397981769932	4.783176130914827e-07	0.017443	One
815	NFKBIZ_1	0.0000162804	0.017443397981769932	3.3994720134388014e-06	0.017443	One
816	PIEZO1_1	0.0000001897	0.017443397981769932	1.8246285080698113e-06	0.017443	One
817	SCN3B_1	0.0000011607	0.017443397981769932	1.5135394267848417e-06	0.017443	One
818	SNAP91_1	0.0000071468	0.017443397981769932	2.638244061314773e-07	0.017443	One
819	TMEM151B_1	0.0000049076	0.017443397981769932	2.6430931809230297e-05	0.017443	One
820	TRAM1_1	0.0000027969	0.017443397981769932	1.6694679799715998e-06	0.017443	One
821	DLGAP2_1	0.0000034653	0.017999463759106323	2.855153777346279e-05	0.017999	One
822	GFRA2_2	0.0000000003	0.018137077932381954	0.000951735145248877	0.018137	One
823	C12orf44_5	0.0000000000	0.018866742690223485	8.109600906363036e-06	0.018867	One
824	CPD_2	0.0000000009	0.018958927953712085	1.967423231238389e-05	0.018959	One
825	UNG_3	0.0000000006	0.019815116785847253	0.00017623188278973096	0.019815	One
826	AGAP2_1	0.0000012045	0.020393810250137884	8.442387558423992e-06	0.020394	One
827	DPY19L4_1	0.0000013827	0.020459674602965643	1.4759797172005466e-06	0.02046	One
828	UST_1	0.0000248242	0.020499190298611462	6.68339412744453e-08	0.020499	One
829	MAP2K7_1	0.0000028217	0.020602652898910816	1.2164780555581337e-05	0.020603	One
830	DLG1_1	0.0000000204	0.02077959376727299	9.890664601929713e-06	0.02078	One
831	MAPK8IP2_1	0.0000001600	0.021209400010728994	1.2744882761058085e-05	0.021209	One
832	TARDBP_3	0.0000000007	0.021265954498108135	6.908159765653427e-06	0.021266	One
833	CYLD_1	0.0000000217	0.0214858173069357	9.879543686944467e-07	0.021486	One
834	ATL2_1	0.0000013494	0.021736958168253658	8.154925885406086e-06	0.021737	One
835	SCAMP5_1	0.0000005258	0.02223324975104475	6.003509085007509e-09	0.022233	One
836	ARL6IP5_1	0.0000000067	0.02225726819150785	1.956141813979619e-06	0.022257	One
837	TUBD1_1	0.0000003011	0.02263296125661172	7.713138636684567e-05	0.022633	One
838	OLFM3_1	0.0000089344	0.022851610694445912	1.8829513375080384e-05	0.022852	One
839	ODC1_2	0.0000008568	0.022971832631374724	2.7504995269216484e-06	0.022972	One
840	EXOSC8_4	0.0000000000	0.022989772746273066	0.0001824993302681246	0.02299	One
841	GEMIN5_4	0.0000000017	0.023273422660848357	7.022368029898661e-07	0.023273	One
842	BCLAF1_1	0.0000031831	0.023433853775319136	1.6892927173134977e-06	0.023434	One
843	ADAMTSL2_3	0.0000000000	0.02345493378746214	2.0324998641713588e-05	0.023455	One
844	GSDMD_1	0.0003698567	0.02361947064385562	1.260266686331163e-05	0.023619	One
845	FILIP1L_1	0.0000442945	0.02380535004803143	4.139244014504424e-06	0.023805	One
846	MPP5_1	0.0000013996	0.024393557193549072	5.899482289097565e-07	0.024394	One
847	ZNF781_2	0.0000000214	0.024442804805679837	0.0002430481092405698	0.024443	One
848	GREB1_1	0.0000021946	0.025082579510674555	1.026168781803766e-06	0.025083	One
849	MICAL2_1	0.0000051045	0.025082579510674555	5.460450875355455e-06	0.025083	One
850	MLKL_1	0.0000245887	0.02520256529276301	1.5181921351787456e-07	0.025203	One
851	HIATL1_1	0.0000001697	0.025698116096895575	0.0006037318193258467	0.025698	One
852	POFUT2_3	0.0000002159	0.025815308401600554	3.356964828070045e-08	0.025815	One
853	FSD1L_3	0.0000000005	0.026091908369487455	0.00039856129823143474	0.026092	One
854	SLC22A4_1	0.0000007929	0.026358068088106524	5.592144002080514e-06	0.026358	One
855	ECE1_1	0.0000040064	0.027281965933944777	3.1606809203074195e-06	0.027282	One
856	FAM120C_1	0.0000001526	0.027478094280566072	9.440653359830993e-06	0.027478	One
857	WDR18_1	0.0000002870	0.02811272649847224	2.0929795909688486e-06	0.028113	One
858	SPAST_2	0.0000001330	0.028348027782966405	3.9367533477728655e-06	0.028348	One
859	RIN2_1	0.0000003608	0.028653860870043152	1.4769971196556159e-05	0.028654	One
860	RUNX2_2	0.0000000005	0.028974052520507214	2.14065240634782e-06	0.028974	One
861	NOP14_2	0.0000005983	0.02901206601493043	9.523685001792411e-07	0.029012	One
862	MAN2B2_1	0.0000027972	0.029245906890336886	1.4933063823416558e-06	0.029246	One
863	PAIP1_1	0.0000007230	0.029320244216402155	2.7441426734443414e-07	0.02932	One
864	DHX32_2	0.0000533846	0.029344624633688917	6.043863871216864e-07	0.029345	One
865	PLK2_2	0.0002388183	0.029905384844343543	2.063197005965159e-06	0.029905	One
866	PRCC_1	0.0000001861	0.029926219059845965	1.1405008131610388e-06	0.029926	One
867	XAF1_1	0.0000358261	0.030280074734233196	7.286165792821834e-08	0.03028	One
868	METAP2_1	0.0000087458	0.030556265901493518	3.240583308159839e-07	0.030556	One
869	CLK2_1	0.0000011413	0.030888289103249412	7.675595673276064e-06	0.030888	One
870	DPP6_1	0.0000000203	0.03100397440582499	5.0469470139700276e-05	0.031004	One
871	ACSL4_3	0.0000020398	0.03149060869705135	1.5068270568910291e-05	0.031491	One
872	ANKIB1_1	0.0000005533	0.032332967518234994	5.693423471624403e-07	0.032333	One
873	MRPL44_1	0.0000004285	0.03320176795710607	7.58534516483232e-07	0.033202	One
874	ECSIT_1	0.0000000613	0.033538144332397844	9.327207467647707e-06	0.033538	One
875	UTRN_1	0.0000011107	0.033538144332397844	2.5789968645189164e-06	0.033538	One
876	KLHL3_1	0.0000383917	0.0344114911006157	3.244555435191599e-05	0.034411	One
877	PPP3CC_1	0.0004859138	0.03515778354911297	6.188875946486586e-05	0.035158	One
878	ZNF146_2	0.0000000002	0.03744996129971014	0.00011861207253864054	0.03745	One
879	ZNF561_1	0.0000000634	0.03880023351870834	2.016596236878262e-06	0.0388	One
880	GABRB3_2	0.0000004163	0.03908988372883462	1.4145265356070185e-06	0.03909	One
881	FUCA2_2	0.0000010455	0.040900774628950205	4.509971577380666e-08	0.040901	One
882	ZNF704_1	0.0000003968	0.04141199786610875	3.2915671737970186e-07	0.041412	One
883	RSRC2_1	0.0000006681	0.04263760212726399	8.124905418115654e-06	0.042638	One
884	ZNF786_4	0.0000003689	0.04302185346161887	0.00017227082461867952	0.043022	One
885	FAM208A_4	0.0000001168	0.04317698799820883	6.901563255423604e-06	0.043177	One
886	KLC1_2	0.0000000029	0.04326421162343569	9.50085593569108e-05	0.043264	One
887	C4orf46_1	0.0000014299	0.04398087969459366	0.0001711178965703045	0.043981	One
888	PFDN2_1	0.0000002586	0.044291333594155616	1.8451067079767974e-09	0.044291	One
889	TMEM88_1	0.0000001338	0.04436920294909983	3.529178026304605e-07	0.044369	One
890	CAMKMT_1	0.0000058447	0.045390286722626634	3.532704674941749e-05	0.04539	One
891	RAB3A_5	0.0000000000	0.04677739444487693	1.0728714113996382e-05	0.046777	One
892	PPP1R3C_1	0.0000160727	0.046988563883468094	6.183139691881509e-07	0.046989	One
893	RNPS1_1	0.0000017303	0.04934110523099186	2.7030460144558537e-06	0.049341	One
894	SESN1_1	0.0000827949	0.049980571686550485	0.00013996827329482083	0.049981	One

Table 8 lists the FRHs associated with head and neck drugs and the markers that define the head and neck cancer drugs and FRHs associated with them.

In addition, [Table 9] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 8].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of the drugs listed in [Table 8], the reactivity correlation values for each drug are divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug reactivity according to the order of drugs listed in [Table 8], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the mean of the calculated values, and『 Rank 』means the number of head and neck cancer drugs that the FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

On the other hand, in FIG. 31, correlation values (P-vlaue) values of the head and neck cancer drugs of the major biomarkers among the biomarkers listed in Table 8 are graphically displayed, and FIG. 32 shows genes expressed by the main biomarkers. The correlation values (P-vlaue) values for both the head and neck cancer drugs are plotted.

Reactive biomarker for head & neck drugs

No.	FRH	Drug	DrugType	Var (marker)
One	RAI14_2	60_BI-2536 / 87_GW843682X / 150_Bicalutamide / 155_AP-24534 / 269_NSC-207895 / 295_NVP-BHG712 / 341_EX-527 / 1016_Temsirolimus / 1032_Afatinib / 1036_PLX4720 / 1057_NVP-BEZ235 / 1061_1212 5Z) -7-Oxozeaenol / 1371_PLX4720 (rescreen) / 1372_Trametinib / 1373_Dabrafenib / 1377_Afatinib (rescreen)	mitosis / mitosis / other / abl / p53 / rtk / other / tor / egfr / erk_mapk / pi3k / erk_mapk / g_integrity / chromatin / wnt / other / erk_mapk / erk_mapk / erk_mapk / egfr	14_21082261_T_G / 7_140753336_A_T
2	ELK3_1	1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 / 1526_Refametinib_3 / 1371_PLX-4720_3 / 1372_Trametinib_1	erk_mapk / other / erk_mapk / erk_mapk / erk_mapk	14_21082261_T_G
3	RAI14_2	1373_Dabrafenib_1 / 1371_PLX-4720_3 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / erk_mapk / other	14_21082261_T_G / 5_94871301_T_G
4	NOTCH2_1	1371_PLX-4720_3 / 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / erk_mapk / other	20_63940084_T_G
5	CATSPER1_1	1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / other	7_140753336_A_T
6	TNIP1_2	1373_Dabrafenib_1 / 1371_PLX-4720_3	erk_mapk / erk_mapk	5_154823483_T_G / 15_32616231_T_G
7	PTX3_2	1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / other	7_140753336_A_T / 14_21082261_T_G
8	ZHX3_1	1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / other	7_72926354_C_T
9	SH2D3A_1	1010_Gefitinib_1 / 1377_Afatinib_1	egfr / egfr	6_129475475_C_T
10	SLC39A13_5	1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3	erk_mapk / other	14_21082261_T_G / 7_140753336_A_T / 11_85724752_T_C / 3_48790461_T_G / 17_35259011_T_G
11	GJB6_1	1032_Afatinib_1 / 1114_Cetuximab_1	egfr / egfr	1_44978366_G_A
12	PLAU_2	1494_SN-38_3 / 1259_Talazoparib_3	DNArep / g_integrity	16_2519752_T_C / 9_114307582_T_G
13	ATG7_1	1373_Dabrafenib_1	erk_mapk	7_140753336_A_T
14	CACNG4_3	1373_Dabrafenib_1	erk_mapk	7_140753336_A_T / 16_11174168_A_G / 6_5771301_A_C
15	GJB2_1	1032_Afatinib_1	egfr	1_44978366_G_A
16	DOCK4_2	1373_Dabrafenib_1	erk_mapk	9_76227464_A_G / 7_140753336_A_T
17	AP1M2_3	1377_Afatinib_1	egfr	1_2521130_T_C / 12_50718803_T_C / 1_2491175_G_A
18	RNF216_1	1021_Axitinib_2	rtk	10_45443298_C_T
19	IRX2_3	1373_Dabrafenib_1	erk_mapk	1_2562891_G_A / 12_14460981_T_A / 7_140753336_A_T
20	CXADR_4	1242_ (5Z) -7-Oxozeaenol_3	other	14_21082261_T_G / 3_47333236_T_C / 18_8387094_T_G / 17_63831142_T_G
21	NEBL_1	1242_ (5Z) -7-Oxozeaenol_3	other	7_72926354_C_T
22	FXYD3_1	1032_Afatinib_1	egfr	22_50625559_G_C
23	SERPINB5_1	1032_Afatinib_1	egfr	22_50625559_G_C
24	GJB3_1	1010_Gefitinib_1	egfr	6_129475475_C_T
25	GJB5_1	1010_Gefitinib_1	egfr	6_129475475_C_T
26	WNT10A_1	1010_Gefitinib_1	egfr	6_129475475_C_T
27	ACLY_1	255_CP724714_2	egfr	15_26976868_T_A
28	KRT6A_1	1114_Cetuximab_1	egfr	22_50576781_G_C
29	PRADC1_1	1037_BX796_2	other	2_53899904_C_T
30	TIMP1_1	1373_Dabrafenib_1	erk_mapk	19_9985806_C_T
31	GYLTL1B_2	1032_Afatinib_1	egfr	7_5938011_C_CCA / 7_5945090_C_T
32	PTCHD4_4	1373_Dabrafenib_1	erk_mapk	11_4102115_C_G / 11_4132537_A_G / 11_4112087_C_A / 11_4138236_G_A

Results of verification of biomarker responsiveness to head & neck drug

No.	FRH	Var_Exp (pval)	Var_Drug (pval)	Exp_Drug (pval)	Ave_VarDrug (pval)	Rank
One	RAI14_2	1.50E-07	0.002427316 / 0.007905787 / 0.009050202 / 0.008885028 / 0.006973327 / 0.008993803 / 0.006448846 / 0.003370265 / 0.005536324 / 7.23E-05 / 0.008957232 / 0.006831953 / 0.007786364 / 0.009533459 / 0.002310426 / 0.006104376 / 2.92E-05 / 0.003064818 / 1.61E05	0.07094644 / 0.187614118 / 0.000121399 / 0.070569119 / 0.006038396 / 0.070019258 / 0.001656899 / 0.051790523 / 0.024868194 / 0.001587975 / 0.005704322 / 0.20488317 / 0.010104768 / 0.019630304 / 0.019900005 / 1.24E-05 / 2.38E-05 / 0.00050772 / 1.09E-06	0.00571	20
2	ELK3_1	0.0000051495	8.520565972551354e-05 / 0.015525162300909256 / 0.022555240944218617 / 9.519623606517973e-05 / 0.007329786178994242	1.490382050697451e-07 / 5.969489582574335e-06 / 6.8362891216619816e-06 / 9.005519185972905e-06 / 6.49148403527597e-05	0.009118	5
3	RAI14_2	0.0000000017	0.0008802720058814783 / 4.733202001463438e-05 / 0.011225192753415226	1.0853407136502757e-06 / 2.4863984008159652e-05 / 1.2422979331681213e-05	0.004051	3
4	NOTCH2_1	0.0003642485	0.0022063266509928054 / 0.0011467762666252258 / 0.03692401606377258	8.758068948702604e-05 / 3.0310746014375745e-05 / 1.8526402456030966e-05	0.013426	3
5	CATSPER1_1	0.0000542935	4.909220079323596e-06 / 0.00011457004964965411	0.0004960672627266704 / 4.1877269236589585e-05	5.97E-05	2
6	TNIP1_2	0.0000000375	0.001606622034643822 / 2.7862939972941576e-05	0.0015404489011240819 / 5.038713072540372e-05	0.000817	2
7	PTX3_2	0.0000000676	1.211019112884484e-05 / 0.004691088270564708	5.3217448419493556e-05 / 4.863050561584803e-06	0.002352	2
8	ZHX3_1	0.0000014893	0.006509687182728191 / 0.008743794449442545	0.0040675934215217225 / 0.00019098934171098681	0.007627	2
9	SH2D3A_1	0.0000000320	0.00986450275259379 / 0.01796408266328998	7.462758949668892e-07 / 1.1020918776918554e-08	0.013914	2
10	SLC39A13_5	0.0000000002	0.00012981264623764855 / 0.030218992308456684	0.0004149038678616304 / 0.00016053338154515	0.015174	2
11	GJB6_1	0.0000254994	0.0011057846043825926 / 0.04337830840329379	4.1575916269860694e-08 / 1.3980763861975182e-05	0.022242	2
12	PLAU_2	0.0000006538	0.03531794281050409 / 0.02526666710345045	4.043892919121399e-05 / 3.9199708585004496e-05	0.030292	2
13	ATG7_1	0.0000274102	4.909220079323596e-06	0.009126969696896518	4.91E-06	One
14	CACNG4_3	0.0000000067	0.00039102555284760144	0.031972846680865336	0.000391	One
15	GJB2_1	0.0000006418	0.0011057846043825926	2.887574461802551e-08	0.001106	One
16	DOCK4_2	0.0000000000	0.0011991500921208242	0.0022356151864022953	0.001199	One
17	AP1M2_3	0.0000000001	0.0033347052264227745	1.674996902910247e-06	0.003335	One
18	RNF216_1	0.0007334440	0.003910529109685535	0.013334064866138773	0.003911	One
19	IRX2_3	0.0000000213	0.0039795105649417465	0.008040031167638424	0.00398	One
20	CXADR_4	0.0000000000	0.004008851856771511	0.00015472825463944093	0.004009	One
21	NEBL_1	0.0000067597	0.008743794449442545	1.0527193471616602e-05	0.008744	One
22	FXYD3_1	0.0008131704	0.009811440592786477	6.611291968968659e-11	0.009811	One
23	SERPINB5_1	0.0000043595	0.009811440592786477	6.545929986856144e-07	0.009811	One
24	GJB3_1	0.0000000848	0.00986450275259379	1.9745785897164974e-07	0.009865	One
25	GJB5_1	0.0000001095	0.00986450275259379	3.7414591927831155e-08	0.009865	One
26	WNT10A_1	0.0000000002	0.00986450275259379	1.0155161311414058e-06	0.009865	One
27	ACLY_1	0.0000197234	0.01038305959856784	0.0002073002808779262	0.010383	One
28	KRT6A_1	0.0000039996	0.011822174156922029	6.092827819585888e-07	0.011822	One
29	PRADC1_1	0.0000003553	0.01619549339490529	4.216127554465152e-06	0.016195	One
30	TIMP1_1	0.0000442505	0.019824604635656325	0.00012088359791880537	0.019825	One
31	GYLTL1B_2	0.0000000917	0.027132275398936593	1.8977666799314624e-07	0.027132	One
32	PTCHD4_4	0.0003324429	0.04021455535799824	0.0022163934450957286	0.040215	One

Table 10 lists the FRHs associated with the lung cancer drug and the markers defining the lung cancer drugs and FRHs associated with them.

In addition, [Table 11] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 10].

In these tables, FRH was expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 10], the reactivity correlation value for each drug is divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug responsiveness according to the order of drugs listed in [Table 10], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average of the calculated values, and『 Rank 』means the number of lung cancer drugs that the FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

On the other hand, in FIG. 33, correlation values (P-vlaue) values of lung biologic drugs of the major biomarkers among the biomarkers listed in Table 10 are graphically displayed, and in FIG. 34, genes expressed by the major biomarkers And P-vlaue values for lung cancer drugs are plotted.

Reactive biomarkers for lung cancer drugs

No.	FRH	Drug	DrugType	Var (marker)
One	POLR3K_5	290_KIN001-260 / 287_KIN001-244 / 308_XL-880 / 261_TL-1-85 / 329_QL-XI-92 / 269_NSC-207895 / 332_XMD15-27 / 1268_XAV 939 / 1495_Olaparib / 260_NG-25 / 265_Tubastatin A / 1011_MBT263 / 1011_MBT263 249_XL-184 / 266_Zibotentan / 273_CUDC-101 / 1021_Axitinib / 277_ABT-869 / 1008_Methotrexate / 272_AR-42 / 271_VNLG / 124 / 288_KIN001-055 / 312_AV-951 / 1375_Temozolomide / 346_THZ-2-102-1 206_Ruxolitinib / 328_SNX-2112 / 91_KIN001-135 / 1017_Olaparib / 300_CX-5461 / 152_CP466722 / 276_CAY10603 / 252_WZ3105 / 257_NPK76-II-72-1 / 1158_XMD11-85h / 226_GSK1070916 / 254_ACSK	other / pi3k / rtk / other / rtk / p53 / other / wnt / g_integrity / other / chromatin / apop / other / rtk / other / chromatin / rtk / rtk / DNArep / chromatin / chromatin / other / rtk / DNArep / cell_cyc / erk_mapk / other / other / other / other / g_integrity / other / g_integrity / chromatin / other / mitosis / other / mitosis / rtk	2_217847583_C_T / 2_71424561_G_GT / 2_217847883_G_A / 2_217848003_A_G / 17_81206909_A_C
2	FAM114A1_1	326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 1248_Daporinad_3 / 299_OSI-027_2 / 269_NSC-207895_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 302_PI-103_3 / 257_NP_763	pi3k / apop / other / metabol / tor / p53 / mitosis / other / pi3k / mitosis / other / rtk	2_217847583_C_T
3	AVPI1_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1007_Docetaxel_1 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1114_Cetuximab_1 / 1015_CI-1040_2 / 1378_Bleomycin_50e_39_391	erk_mapk / erk_mapk / other / erk_mapk / cytoskeleton / erk_mapk / erk_mapk / egfr / erk_mapk / DNArep / wnt / other	3_157413999_A_C
4	S100A11_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1377_Afatinib_1 / 172_Embelin_2 / 1060_PD0325901_2 / 207_AS601245_3 / 1114_Cetuximab_1 / 1404	erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / egfr / apop / erk_mapk / jnk_p38 / egfr / DNArep / egfr	11_124145287_C_T
5	TMEM92_2	1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 159_HG6-64-1_3 / 201_Epothilone B_2 / 1007_Docetaxel_1 / 207_AS601L_Culture	other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk / cytoskeleton / cytoskeleton / jnk_p38 / other / cell_cyc	8_1565648_A_G / 9_61104415_C_T
6	ATP6V0B_1	1378_Bleomycin (50uM) _1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 1498_Selumetinib_2 / 1016_Temsirolimus_1 / 172_Embelin_2 / 59_WZ-1-84_3_1_fati /	DNArep / erk_mapk / erk_mapk / abl / cytoskeleton / erk_mapk / erk_mapk / tor / apop / other / egfr / egfr	17_78529723_C_G
7	GBP1_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 182_Obatoclax Mesylate_2 / 167_OSU-03012_3 / 1062_Selumetinib_2 / 51_Dasatinib	erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton / erk_mapk / apop / pi3k / erk_mapk / abl	3_55480738_A_T
8	ERLEC1_1	326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 312_Tivozanib_2 / 302_PI-103_3 / 222_BX-912_3 / 329_QL-XI-92_3	pi3k / apop / other / tor / other / rtk / pi3k / pi3k / rtk	10_52768593_C_G
9	SSH3_1	1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1114_Cetuximab_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 / 1378_Bleomycin (50uM) _1	erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / egfr / erk_mapk / DNArep	3_7680310_G_A
10	TRIP10_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1378_Bleomycin (50uM) _1 / 1054_Palbociclib_2 / 1007_Docetaxel_1	erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk / DNArep / cell_cyc / cytoskeleton	14_20381224_T_G
11	MAN1B1_5	1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1015_CI-1040_2 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / other	19_57490144_T_A / 19_57473550_A_G / 19_57507480_A_G / 19_57455681_G_T / 19_57455765_G_A
12	CD151_2	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 172_Embelin_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 182_Obatoclax Mesylate_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / apop / erk_mapk / other / apop	3_3845235_C_T / 3_3845163_G_C
13	PDLIM7_1	1007_Docetaxel_1 / 159_HG6-64-1_3 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1498_Selumetinib_2 / 1062_Selumetinib_2	cytoskeleton / erk_mapk / other / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk	16_84872374_G_C
14	GLIPR1_1	1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1054_Palbociclib_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2	erk_mapk / cytoskeleton / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk / other	16_55398_G_T
15	GPR87_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1378_Bleomycin (50uM) _1	erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / DNArep	19_15807367_G_T
16	SNAP25_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1007_Docetaxel_1	erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / cytoskeleton	2_71424561_G_GT
17	FGFBP1_2	1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1010_Gefitinib_1 / 1015_CI-1040_2	erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / erk_mapk	2_65069680_A_C / 17_81206909_A_C
18	CHN1_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1015_CI-1040_2 / 1010_Gefitinib_1	erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk / egfr	17_81206909_A_C
19	ACSF2_4	1372_Trametinib_1 / 1526_Refametinib_3 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1377_Afatinib_1 / 1026_Tanespimycin_2	erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr / other	2_71424561_G_GT / 2_71433365_T_TC / 2_71393433_A_G / 2_71428456_T_A
20	SNAPC3_1	1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1007_Docetaxel_1	erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton	15_71256598_T_C
21	ZFP82_1	1377_Afatinib_1 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 / 1526_Refametinib_3 / 1032_Afatinib_1 / 1010_Gefitinib_1	egfr / erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr	3_33120406_C_T
22	OPHN1_1	1016_Temsirolimus_1 / 1007_Docetaxel_1 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1526_Refametinib_3 / 1019_Bosutinib_1 / 1026_Tanespimycin_2	tor / cytoskeleton / erk_mapk / cell_cyc / erk_mapk / abl / other	12_54002598_T_G
23	TNS3_1	1014_Refametinib_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk	7_47967711_A_T
24	P2RY6_5	1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1014_Refametinib_2	erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk	2_71424561_G_GT / 2_71399439_CTA_C / 2_71398637_G_A / 2_71393433_A_G / 2_71428456_T_A
25	SCO2_3	1026_Tanespimycin_2 / 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1170_CCT-018159_3 / 1014_Refametinib_2	other / erk_mapk / cytoskeleton / erk_mapk / other / erk_mapk	X_14581235_C_G / X_14581237_T_G / X_55487442_C_G
26	KHSRP_1	302_PI-103_3 / 299_OSI-027_2 / 252_WZ3105_3 / 301_PHA-793887_3 / 330_XMD13-2_3 / 1248_Daporinad_3	pi3k / tor / other / cell_cyc / other / metabol	4_119158232_G_A
27	TTC3_1	1007_Docetaxel_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1	cytoskeleton / other / erk_mapk / erk_mapk / erk_mapk / egfr	12_66128870_G_A
28	STEAP1_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk	17_50677651_A_G
29	RNF207_2	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1015_CI-1040_2 / 1026_Tanespimycin_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other	9_134036501_T_G / 16_68564104_A_G
30	C16orf59_2	257_NPK76-II-72-1_3 / 1248_Daporinad_3 / 269_NSC-207895_3 / 265_Tubastatin A_3 / 275_I-BET-762_3	mitosis / metabol / p53 / chromatin / chromatin	2_217847583_C_T / 2_217847883_G_A
31	ICAM1_1	1372_Trametinib_1 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1526_Refametinib_3 / 159_HG6-64-1_3	erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk	8_12358868_A_G
32	POLE_1	1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 / 1012_Vorinostat_1 / 1248_Daporinad_3	apop / p53 / rtk / chromatin / metabol	2_217847583_C_T
33	MYT1_3	1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 / 211_TL-2-105_3 / 326_GSK690693_3	apop / metabol / p53 / erk_mapk / pi3k	2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A
34	MMRN2_1	1377_Afatinib_1 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1114_Cetuximab_1 / 1498_Selumetinib_2	egfr / erk_mapk / erk_mapk / egfr / erk_mapk	19_15807367_G_T
35	ZNF420_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1	erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton	6_53654807_C_T
36	ELOVL1_2	1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1014_Refametinib_2	erk_mapk / erk_mapk / other / erk_mapk / erk_mapk	1_203683316_A_G / 1_203698281_T_C
37	CHGB_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk	15_67236036_T_G
38	MLKL_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / other	17_80137479_A_T
39	FEZ2_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1007_Docetaxel_1 / 1239_YK-4-279_3 / 1060_PD0325901_2	erk_mapk / erk_mapk / cytoskeleton / other / erk_mapk	X_108735142_T_G
40	ADNP2_1	1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1	other / erk_mapk / erk_mapk / erk_mapk	9_41294004_C_A
41	CES2_1	1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1010_Gefitinib_1	erk_mapk / erk_mapk / erk_mapk / egfr	8_17085328_C_T
42	DDR1_2	1377_Afatinib_1 / 1010_Gefitinib_1 / 1032_Afatinib_1 / 1372_Trametinib_1	egfr / egfr / egfr / erk_mapk	2_174801578_A_G / 4_89936328_G_A
43	PTGR1_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1014_Refametinib_2	erk_mapk / erk_mapk / other / erk_mapk	19_45698914_C_T
44	LIN7A_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	13_45541596_C_A
45	SYNCRIP_1	257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 301_PHA-793887_3 / 222_BX-912_3	mitosis / other / cell_cyc / pi3k	4_87340676_A_C
46	EREG_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	17_50677651_A_G
47	C12orf57_1	1007_Docetaxel_1 / 1114_Cetuximab_1 / 1372_Trametinib_1 / 204_Tipifarnib_2	cytoskeleton / egfr / erk_mapk / other	1_103082763_C_G
48	PARP9_1	1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2	egfr / erk_mapk / erk_mapk / erk_mapk	4_185267219_TA_T
49	SLITRK3_1	1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk / erk_mapk	8_378251_A_G
50	BIRC7_2	1372_Trametinib_1 / 1066_AZD6482_2 / 1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / pi3k / erk_mapk / erk_mapk	17_78510525_G_A / 17_78507511_T_C
51	ID4_1	173_FH535_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 / 1372_Trametinib_1	other / erk_mapk / apop / erk_mapk	4_9334816_T_C
52	NUCB2_1	1142_HG-5-113-01_2 / 1054_Palbociclib_2 / 182_Obatoclax Mesylate_2 / 1239_YK-4-279_3	abl / cell_cyc / apop / other	8_26370124_A_G
53	PDLIM1_2	1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1010_Gefitinib_1	egfr / erk_mapk / erk_mapk / egfr	11_124186080_G_A / 11_124224942_C_A
54	RNF219_3	1011_Navitoclax_2 / 269_NSC-207895_3 / 230_GSK429286A_3 / 226_GSK1070916_2	apop / p53 / cytoskeleton / mitosis	10_31363289_T_C / 2_68528704_T_C / 16_60358945_T_C
55	CTRB2_1	1378_Bleomycin (50uM) _1 / 1242_ (5Z) -7-Oxozeaenol_3 / 1372_Trametinib_1 / 1526_Refametinib_3	DNArep / other / erk_mapk / erk_mapk	4_37433902_C_T
56	RAB31_2	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	X_81277112_A_C / 6_32027037_A_C
57	INADL_2	1010_Gefitinib_1 / 1377_Afatinib_1 / 1032_Afatinib_1	egfr / egfr / egfr	3_58285236_T_C / 2_241246976_C_T
58	DPYSL4_5	1011_Navitoclax_2 / 269_NSC-207895_3 / 275_I-BET-762_3	apop / p53 / chromatin	2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217847379_A_G / 2_217842134_T_C
59	TMEM71_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	8_12358868_A_G
60	TPD52L2_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	9_134036501_T_G
61	PDIA3_2	269_NSC-207895_3 / 1011_Navitoclax_2 / 193_GW-2580_3	p53 / apop / rtk	10_52768593_C_G / 15_19964850_A_G
62	KCNK6_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	17_81206909_A_C
63	CASP8AP2_2	1011_Navitoclax_2 / 326_GSK690693_3 / 269_NSC-207895_3	apop / pi3k / p53	6_109431362_C_A / 10_24584658_G_C
64	LIG1_2	1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3	apop / p53 / rtk	2_217847583_C_T / 2_217848003_A_G
65	ARVCF_1	1526_Refametinib_3 / 1372_Trametinib_1 / 172_Embelin_2	erk_mapk / erk_mapk / apop	15_71256598_T_C
66	PPP1R13L_1	1011_Navitoclax_2 / 211_TL-2-105_3 / 254_Quizartinib_2	apop / erk_mapk / rtk	7_33099535_G_A
67	ELL2_1	1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3	apop / metabol / p53	6_32183680_C_G
68	TMEM74_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1378_Bleomycin (50uM) _1	erk_mapk / erk_mapk / DNArep	15_67236036_T_G
69	SH3KBP1_1	207_AS601245_3 / 172_Embelin_2 / 204_Tipifarnib_2	jnk_p38 / apop / other	8_12358868_A_G
70	AGXT2L2_4	1011_Navitoclax_2 / 193_GW-2580_3 / 269_NSC-207895_3	apop / rtk / p53	2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217848559_G_A
71	FLNA_1	159_HG6-64-1_3 / 153_Midostaurin_2 / 51_Dasatinib_1	erk_mapk / rtk / abl	3_118902653_C_T
72	EVPL_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1	erk_mapk / erk_mapk / egfr	15_84798628_G_A
73	ITPRIPL1_1	1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk	2_24209270_T_C
74	MFSD5_3	1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3	erk_mapk / other / erk_mapk	10_96386941_T_G / 10_93374837_C_T / 12_9153310_A_C
75	IL31RA_1	180_Thapsigargin_3 / 1372_Trametinib_1 / 159_HG6-64-1_3	other / erk_mapk / erk_mapk	4_20727343_G_C
76	PTP4A3_1	1007_Docetaxel_1 / 1372_Trametinib_1 / 1526_Refametinib_3	cytoskeleton / erk_mapk / erk_mapk	X_92201459_T_G
77	MMP14_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	15_99729430_G_C
78	CAND2_3	1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	X_101102428_CT_C / X_101102205_C_G / X_101102212_T_C
79	ZNF292_5	1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3	other / erk_mapk / erk_mapk	6_32027037_A_C / 12_130357070_A_C / 20_1445690_A_C / X_116441009_T_G / 5_40853381_T_G
80	EPSTI1_1	167_OSU-03012_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2	pi3k / erk_mapk / apop	2_226796327_T_C
81	CD97_5	1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3	other / erk_mapk / erk_mapk	7_108514148_A_C / 12_108517007_T_G / 17_80137479_A_T / 5_141193109_A_G / 4_8036186_A_G
82	POLE4_5	1026_Tanespimycin_2 / 1526_Refametinib_3 / 1007_Docetaxel_1	other / erk_mapk / cytoskeleton	2_218618671_A_C / 16_72107293_C_G / 11_47315255_C_G / 21_46116692_T_G / 1_220001162_G_T
83	ZDHHC5_2	1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3	erk_mapk / erk_mapk / erk_mapk	7_101136942_T_G / 16_89729370_A_C
84	CAV1_1	1011_Navitoclax_2 / 211_TL-2-105_3 / 193_GW-2580_3	apop / erk_mapk / rtk	10_133626829_C_T
85	PRDM15_1	1114_Cetuximab_1 / 1372_Trametinib_1 / 1526_Refametinib_3	egfr / erk_mapk / erk_mapk	5_181333681_C_T
86	TXNL4A_1	1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3	erk_mapk / other / erk_mapk	11_124397016_A_G
87	PITX1_1	1268_XAV939_3 / 1372_Trametinib_1 / 1526_Refametinib_3	wnt / erk_mapk / erk_mapk	10_43373649_C_A
88	CDCA5_1	1011_Navitoclax_2 / 269_NSC-207895_3	apop / p53	2_217847583_C_T
89	S100A8_1	1377_Afatinib_1 / 1527_Pictilisib_2	egfr / pi3k	19_7746529_A_C
90	ZNF345_2	207_AS601245_3 / 1007_Docetaxel_1	jnk_p38 / cytoskeleton	6_53654807_C_T / 1_153772281_T_G
91	CXXC1_2	51_Dasatinib_1 / 1372_Trametinib_1	abl / erk_mapk	3_112199369_A_G / 2_119254595_G_A
92	ANO4_1	1526_Refametinib_3 / 1372_Trametinib_1	erk_mapk / erk_mapk	9_41294004_C_A
93	STAG2_1	1526_Refametinib_3 / 1372_Trametinib_1	erk_mapk / erk_mapk	3_10819431_A_G
94	PBX4_1	1011_Navitoclax_2 / 269_NSC-207895_3	apop / p53	1_101786406_G_A
95	RRM1_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	2_217847583_C_T
96	NUPL1_2	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	19_11666277_T_C / 10_31363289_T_C
97	MCFD2_2	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	1_161518073_C_T / 1_161518227_T_C
98	IKBKAP_1	1011_Navitoclax_2 / 269_NSC-207895_3	apop / p53	10_52768593_C_G
99	KHK_2	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	2_217847583_C_T / 2_217848003_A_G
100	SEMA4B_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	7_92469651_G_A
101	CEP41_1	1526_Refametinib_3 / 1372_Trametinib_1	erk_mapk / erk_mapk	13_36365551_C_T
102	DTX3L_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	4_185267219_TA_T
103	SMC2_1	1011_Navitoclax_2 / 269_NSC-207895_3	apop / p53	15_62657955_G_C
104	HDAC6_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	13_45503246_G_A
105	KDM3A_1	1060_PD0325901_2 / 207_AS601245_3	erk_mapk / jnk_p38	9_61211264_T_G
106	DCAKD_1	1011_Navitoclax_2 / 1248_Daporinad_3	apop / metabol	6_32183680_C_G
107	DUSP5_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	6_32183680_C_G
108	PRPF40A_2	301_PHA-793887_3 / 252_WZ3105_3	cell_cyc / other	4_189953012_G_A / 2_237772072_T_G
109	PPIB_4	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G
110	ERAP2_2	1372_Trametinib_1 / 1026_Tanespimycin_2	erk_mapk / other	5_96986715_C_T / 5_96917400_T_C
111	BAALC_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	15_67236036_T_G
112	CACNA2D2_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	15_67236036_T_G
113	CNPY4_1	1377_Afatinib_1 / 288_WHI-P97_3	egfr / other	17_48728228_G_A
114	ANO5_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	12_9427796_G_T
115	KLK6_2	1372_Trametinib_1 / 288_WHI-P97_3	erk_mapk / other	4_48170249_G_A / 4_48170201_C_T
116	TNIP2_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	7_33099535_G_A
117	KCNJ11_4	1011_Navitoclax_2 / 293_Amuvatinib_2	apop / rtk	2_217847583_C_T / 2_217847883_G_A / 2_217848559_G_A / 2_217848003_A_G
118	MED14_1	193_GW-2580_3 / 269_NSC-207895_3	rtk / p53	2_95859911_C_T
119	PDGFC_3	1026_Tanespimycin_2 / 1016_Temsirolimus_1	other / tor	5_150896225_C_T / 5_150898617_C_T / 5_150903222_T_C
120	SLFN12_2	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	1_241723452_T_C / 1_241723462_A_G
121	PDP1_5	1372_Trametinib_1 / 1377_Afatinib_1	erk_mapk / egfr	15_25189495_C_T / 15_25194819_G_A / 15_25199636_G_A / 4_87811722_A_G / 15_25185507_G_A
122	IER5L_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	9_34623341_A_G
123	ABCA5_2	1372_Trametinib_1 / 1026_Tanespimycin_2	erk_mapk / other	17_50677651_A_G / 17_78529677_G_C
124	CABP7_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	1_46344858_A_G
125	FCRLB_5	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	2_118982373_A_G / 17_81276033_A_C / X_132085721_T_C / 15_82463815_A_C / 9_41189241_T_C
126	TIGD3_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	5_135888024_G_T
127	ZNF295_1	159_HG6-64-1_3 / 1526_Refametinib_3	erk_mapk / erk_mapk	11_113854221_T_C
128	PLD2_1	1114_Cetuximab_1 / 288_WHI-P97_3	egfr / other	15_84407910_G_A
129	CD55_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	5_113384951_C_A
130	QKI_3	1242_ (5Z) -7-Oxozeaenol_3 / 1007_Docetaxel_1	other / cytoskeleton	6_87514446_T_C / 6_87612279_G_A / 6_87511385_T_C
131	MZT1_1	1011_Navitoclax_2 / 269_NSC-207895_3	apop / p53	10_31363289_T_C
132	SEMA7A_1	1372_Trametinib_1 / 182_Obatoclax Mesylate_2	erk_mapk / apop	22_24253656_C_G
133	ROR2_1	1372_Trametinib_1 / 1377_Afatinib_1	erk_mapk / egfr	13_44436731_C_T
134	TRIP6_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	17_78529677_G_C
135	C14orf142_1	1242_ (5Z) -7-Oxozeaenol_3 / 1378_Bleomycin (50uM) _1	other / DNArep	11_66055499_T_G
136	ZEB1_2	1377_Afatinib_1 / 1032_Afatinib_1	egfr / egfr	3_58285236_T_C / 9_41905830_C_G
137	NIP7_2	344_THZ-2-49_3 / 1007_Docetaxel_1	cell_cyc / cytoskeleton	9_33529025_G_T / 9_122724363_T_G
138	GNAO1_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	10_133626013_G_A
139	FGF9_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	13_32131648_A_G
140	SERINC3_1	1114_Cetuximab_1 / 1526_Refametinib_3	egfr / erk_mapk	2_25980839_T_G
141	RSBN1_1	1026_Tanespimycin_2 / 1372_Trametinib_1	other / erk_mapk	2_127286836_G_C
142	ARVCF_1	1011_Navitoclax_2 / 193_GW-2580_3	apop / rtk	10_133626829_C_T
143	DTL_1	269_NSC-207895_3 / 326_GSK690693_3	p53 / pi3k	2_29239654_G_A
144	SRSF7_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	5_181333681_C_T
145	IFIT5_2	1526_Refametinib_3 / 1372_Trametinib_1	erk_mapk / erk_mapk	6_169632990_G_A / 6_169665646_G_A
146	NARF_1	1007_Docetaxel_1 / 1526_Refametinib_3	cytoskeleton / erk_mapk	12_32328439_A_C
147	CASP8_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	17_75904383_G_C
148	IL17RB_1	1239_YK-4-279_3 / 1526_Refametinib_3	other / erk_mapk	19_44506064_G_T
149	SLC15A2_1	1377_Afatinib_1	egfr	2_174801578_A_G
150	SAR1B_1	193_GW-2580_3	rtk	5_155013898_A_G
151	TTC1_1	1011_Navitoclax_2	apop	5_155013898_A_G
152	CRP_2	165_DMOG_3	other	9_129834783_A_C / 17_69536247_A_G
153	GGCX_1	1011_Navitoclax_2	apop	19_39875355_A_T
154	SOX9_1	1066_AZD6482_2	pi3k	11_1092981_A_C
155	DLX5_3	1011_Navitoclax_2	apop	2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T
156	SNRNP25_3	1011_Navitoclax_2	apop	2_217847883_G_A / 2_217847583_C_T / 2_217848003_A_G
157	UHRF1BP1L_1	29_AZ628_3	erk_mapk	2_113594958_C_G
158	PAPD4_1	1011_Navitoclax_2	apop	19_54274840_G_A
159	ADAMTS14_1	1011_Navitoclax_2	apop	19_52554226_G_A
160	FAT2_1	1377_Afatinib_1	egfr	19_15807367_G_T
161	ZNF750_2	1377_Afatinib_1	egfr	19_15807367_G_T / 19_15794719_C_A
162	BTG2_1	1026_Tanespimycin_2	other	6_34872273_T_G
163	PIGB_4	1011_Navitoclax_2	apop	15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G
164	WHAMM_4	1011_Navitoclax_2	apop	15_59207967_A_G / 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C
165	PELI2_2	1011_Navitoclax_2	apop	9_114169457_C_T / 17_68420216_C_T
166	RPS5_1	302_PI-103_3	pi3k	10_89339873_T_C
167	DALRD3_1	1011_Navitoclax_2	apop	1_244857989_TA_T
168	ANKRD22_1	1372_Trametinib_1	erk_mapk	17_81206909_A_C
169	AGBL4_5	1011_Navitoclax_2	apop	2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T / 2_217842134_T_C / 2_217847379_A_G
170	DCUN1D2_1	1011_Navitoclax_2	apop	10_31363289_T_C
171	RAP2A_1	1011_Navitoclax_2	apop	10_31363289_T_C
172	TEX30_1	1011_Navitoclax_2	apop	10_31363289_T_C
173	CPNE8_1	1011_Navitoclax_2	apop	X_24055660_C_A
174	IFIT3_1	1011_Navitoclax_2	apop	18_50806833_C_G
175	KCNMB2_1	1011_Navitoclax_2	apop	18_50806833_C_G
176	TRIM21_1	1011_Navitoclax_2	apop	18_50806833_C_G
177	NAP1L4_1	1011_Navitoclax_2	apop	12_27969552_T_A
178	GALNT3_1	1377_Afatinib_1	egfr	3_7680310_G_A
179	EVL_1	1011_Navitoclax_2	apop	7_33264495_A_G
180	TSPAN8_1	1242_ (5Z) -7-Oxozeaenol_3	other	14_59565278_G_A
181	RUNDC3B_1	1011_Navitoclax_2	apop	4_68236279_G_GA
182	CCDC113_1	1054_Palbociclib_2	cell_cyc	16_67199408_A_C
183	PIAS2_2	1526_Refametinib_3	erk_mapk	18_49837560_A_G / 18_49837561_G_C
184	ALG14_1	1023_GW441756_3	rtk	12_27755086_G_GA
185	TAF11_1	1011_Navitoclax_2	apop	15_84516674_T_G
186	KCNK9_1	193_GW-2580_3	rtk	10_28880454_A_G
187	LRRC8A_1	1377_Afatinib_1	egfr	5_173158713_A_G
188	TMEM151B_1	1372_Trametinib_1	erk_mapk	9_67920363_C_T
189	C10orf76_1	1007_Docetaxel_1	cytoskeleton	2_169557387_G_GA
190	NXNL2_1	1007_Docetaxel_1	cytoskeleton	12_54002598_T_G
191	TCEB3_1	330_XMD13-2_3	other	14_67333008_A_G
192	CPEB2_2	266_Zibotentan_2	other	8_22102127_A_G / 8_22102128_C_T
193	TUBB_1	193_GW-2580_3	rtk	1_101786406_G_A
194	UBE2H_1	1011_Navitoclax_2	apop	2_9279286_C_T
195	TM9SF4_1	1526_Refametinib_3	erk_mapk	9_41294004_C_A
196	ZNF250_1	1011_Navitoclax_2	apop	5_135888024_G_T
197	ARSD_1	269_NSC-207895_3	p53	1_101786406_G_A
198	ZBED5_5	1026_Tanespimycin_2	other	5_176529597_A_C / 14_69704655_C_T / 11_62807431_T_G / 7_99486962_A_C / 5_138430313_A_C
199	TEAD3_3	1011_Navitoclax_2	apop	18_166710_TTAAAA_T / 18_166819_T_C / 18_264012_G_A
200	PAICS_1	1377_Afatinib_1	egfr	19_50637249_G_A
201	SDSL_1	1026_Tanespimycin_2	other	3_31664157_C_T
202	SP140L_1	1011_Navitoclax_2	apop	19_9857463_G_A
203	VEZF1_1	1011_Navitoclax_2	apop	4_122258745_C_T
204	TSR2_2	1011_Navitoclax_2	apop	8_109271027_T_C / 8_109271124_T_G
205	LRFN5_1	1011_Navitoclax_2	apop	10_3165440_A_G
206	HMOX1_3	1026_Tanespimycin_2	other	1_183239405_G_A / 20_39018962_A_C / 2_86785910_T_G
207	OAF_2	1011_Navitoclax_2	apop	9_83978162_A_T / 9_83976942_T_C
208	C1orf198_1	193_GW-2580_3	rtk	20_6215106_T_C
209	RNF145_1	193_GW-2580_3	rtk	15_65447029_G_A
210	TFDP1_2	1011_Navitoclax_2	apop	10_31363289_T_C / 16_60358945_T_C
211	TRIM33_5	1026_Tanespimycin_2	other	5_176575310_A_C / 6_136362716_T_G / 4_78315728_T_G / 22_42516026_A_G / 12_14806481_T_G
212	BRD1_1	147_NSC-87877_3	other	5_154002958_G_A
213	RAB18_1	1011_Navitoclax_2	apop	3_146194512_C_T
214	DOK6_1	1011_Navitoclax_2	apop	18_12840880_T_C
215	TMEM132D_1	1011_Navitoclax_2	apop	1_89592683_G_GT
216	RBKS_1	1011_Navitoclax_2	apop	7_140126550_T_A
217	SDPR_1	1372_Trametinib_1	erk_mapk	15_23364667_T_G
218	HADHB_3	1011_Navitoclax_2	apop	19_48944320_G_A / 19_48944456_G_A / 19_48942517_C_T
219	RAB2B_1	1011_Navitoclax_2	apop	15_20251568_G_A
220	CLSPN_2	1011_Navitoclax_2	apop	15_62651935_A_G / 15_62657955_G_C
221	LRCH2_1	1372_Trametinib_1	erk_mapk	19_1825787_T_TA
222	RIC8B_1	1011_Navitoclax_2	apop	3_39412024_A_G
223	SNX17_1	1026_Tanespimycin_2	other	17_43879789_T_G
224	HPS1_3	1026_Tanespimycin_2	other	9_136463607_G_A / 9_136476782_G_A / 9_136453326_A_G
225	TNNT3_1	1377_Afatinib_1	egfr	2_226796327_T_C
226	MPHOSPH9_1	257_NPK76-II-72-1_3	mitosis	14_104949986_T_C
227	PCDH7_1	1372_Trametinib_1	erk_mapk	11_64284449_A_C
228	NSL1_1	193_GW-2580_3	rtk	3_75665457_C_T
229	ALG9_1	1011_Navitoclax_2	apop	14_76498312_C_T
230	PDE12_1	1006_Cytarabine_1	DNArep	1_161518073_C_T
231	PAPSS2_1	173_FH535_3	other	1_485270_G_A
232	ZFHX2_1	1011_Navitoclax_2	apop	9_27567147_C_T
233	TFG_2	1011_Navitoclax_2	apop	X_16150554_T_C / X_16150344_T_C
234	IL15RA_1	1011_Navitoclax_2	apop	22_36566306_C_G
235	MBTD1_1	1248_Daporinad_3	metabol	22_36566306_C_G
236	TMPRSS4_1	1372_Trametinib_1	erk_mapk	11_18484085_G_A
237	APBB1_1	1011_Navitoclax_2	apop	7_117548606_ATG_A
238	MAD2L2_1	1011_Navitoclax_2	apop	7_117548606_ATG_A
239	MAP4_1	1011_Navitoclax_2	apop	7_33099535_G_A
240	GLTP_1	1377_Afatinib_1	egfr	2_182994745_T_C
241	CECR2_1	1011_Navitoclax_2	apop	15_30596563_A_G
242	RUFY1_1	1011_Navitoclax_2	apop	17_73212821_T_C
243	LRRN1_3	1372_Trametinib_1	erk_mapk	10_26492426_T_C / 4_654142_G_A / 14_67347493_A_C
244	ATRIP_1	1026_Tanespimycin_2	other	19_815835_G_A
245	NADKD1_1	1011_Navitoclax_2	apop	3_16323447_C_T
246	DAPL1_5	1026_Tanespimycin_2	other	15_78923063_A_C / 1_2588455_T_G / 20_32797074_C_A / 14_69704655_C_T / 17_7701545_A_C
247	HSD17B10_1	1011_Navitoclax_2	apop	5_24511259_C_T
248	CTSL1_5	1526_Refametinib_3	erk_mapk	7_6857531_A_G / 10_62069760_A_C / 17_80137479_A_T / X_52907336_A_C / 3_62493670_T_G
249	PPM1F_2	1031_Elesclomol_2	other	14_72893955_C_G / 16_29382935_T_G
250	SERPINB8_1	1248_Daporinad_3	metabol	6_69361281_G_A
251	LEPREL4_1	1011_Navitoclax_2	apop	19_11116804_A_C
252	HIRA_1	225_Genentech Cpd 10_3	mitosis	9_41341340_C_T
253	MET_2	1011_Navitoclax_2	apop	10_133626013_G_A / 10_133626012_T_A
254	ST18_2	1011_Navitoclax_2	apop	10_133626012_T_A / 10_133626013_G_A
255	IFI35_1	1372_Trametinib_1	erk_mapk	12_15589379_GA_G
256	CNKSR3_1	1166_QL-VIII-58_3	tor	17_78539866_T_C
257	NFKBIZ_1	1372_Trametinib_1	erk_mapk	6_47579334_T_TAA
258	TFPI_1	1372_Trametinib_1	erk_mapk	6_47579334_T_TAA
259	PDIA6_1	1011_Navitoclax_2	apop	11_17498150_C_G
260	RSF1_3	1026_Tanespimycin_2	other	8_143870873_T_G / 1_54986510_A_C / 12_14806481_T_G
261	MYO1E_2	1372_Trametinib_1	erk_mapk	15_25170856_G_A / X_153670877_G_T
262	UBAP1_1	1372_Trametinib_1	erk_mapk	5_31510999_G_T
263	GFER_1	1026_Tanespimycin_2	other	2_85639407_A_C
264	C17orf75_1	211_TL-2-105_3	erk_mapk	6_32183680_C_G
265	TTC9B_1	1011_Navitoclax_2	apop	17_74541739_G_A
266	FAM198B_1	211_TL-2-105_3	erk_mapk	6_106519310_A_C
267	DCTD_1	1026_Tanespimycin_2	other	8_7429219_C_T
268	ZSCAN16_1	1011_Navitoclax_2	apop	7_26185482_G_A
269	CCDC14_2	1372_Trametinib_1	erk_mapk	7_33357933_C_A / 9_33529025_G_T
270	TRIP11_1	1011_Navitoclax_2	apop	1_230792766_C_G
271	NKAIN2_1	1011_Navitoclax_2	apop	1_169804019_T_C
272	NT5E_1	1011_Navitoclax_2	apop	1_169804019_T_C
273	PPP1R14A_5	196_Phenformin_3	metabol	15_57438247_A_C / 5_76209739_T_G / X_149774713_G_C / 1_35479062_T_G / 9_109406442_T_C
274	CDH2_1	1241_CHIR-99021_3	wnt	1_155060858_G_A
275	EMC3_1	151_QS11_3	other	1_197039467_A_C
276	NCAPG2_1	6_PHA-665752_3	rtk	1_149021276_A_C
277	OR13H1_2	166_FTI-277_3	other	2_201728736_A_G / 2_201723527_C_T

Results of verification of biomarker responsiveness to lung cancer drugs

No.	FRH	Var_Exp (pval)	Var_Drug (pval)	Exp_Drug (pval)	Ave_VarDrug (pval)	Rank
One	POLR3K_5	1.67E-06	7.55E-05 / 9.21E-05 / 0.000406169 / 0.000572894 / 0.000596706 / 0.000830024 / 0.000897369 / 0.000943017 / 0.00100282 / 0.001405937 / 0.001436612 / 0.001463281 / 0.001585317 / 0.00161475 / 0.001676489 / 0.001964123 / 0.00196632 / 0.002055398 / 0.002082114 / 0.002914256 / 0.002947382 / 0.003272641 / 0.003463499 / 0.00367462 / 0.00367676 / 0.003769026 / 0.003782462 / 0.004059938 / 0.004512707 / 0.005161898 / 0.005787569 / 0.006314892 / 0.006945435 / 0.008072051 / 0.008410403 / 0.008931324	0.001531019 / 0.057569018 / 0.249595562 / 0.085576027 / 0.000387243 / 1.59E-05 / 0.059525284 / 0.863014405 / 0.249659436 / 0.124147024 / 0.000281163 / 7.11E-06 / 0.019500847 / 0.695397999 / 0.001918781 / 0.086727092 / 0.023202587 / 0.000441974 / / 0.036578315 / 0.000474321 / 0.011974306 / 0.079370245 / 0.828009563 / 0.010696272 / 0.005232793 / 0.582545022 / 0.058088741 / 0.00262003 / 0.049789754 / 0.228619231 / 0.001174198 / 7.02E-05 / 1.63E-06 / 0.295541863 / 7.79E-06 / 3.75E-05	2.97E-03	39
2	FAM114A1_1	0.0000025505	0.0042694104092888974 / 0.00020876871631167866 / 0.0007568114081113288 / 0.0035305946391629545 / 0.008363870991709823 / 1.4383640936438872e-05 / 7.009824754153582e-05 / 0.0035938658204617215 / 0.006293754132220173 / 0.0032074496683567847 / 0.0204010340651556	1.985359164220784e-08 / 1.9619211144338805e-07 / 1.1786246361826978e-07 / 1.2984459856816525e-07 / 6.679222855070028e-07 / 7.60276325486698e-06 / 4.381181635105041e-08 / 3.0395531368179466e-06 / 3.92186793718892e-06534 / 2.2310227467645046e-05 / 6.449074536371506e-07	0.004255434	12
3	AVPI1_1	0.0000003933	0.0006396902026437372 / 0.0035535295006568564 / 0.004142441090345042 / 0.008737166819403942 / 0.005365726625203914 / 0.016265715773138612 / 0.041737910661353794 / 0.03071155447434498 / 0.012033224729341468 / 0.013915501344307473 / 0.009991096973902677 / 0.01939906554836552	8.724099353866297e-18 / 4.327010736165959e-17 / 8.775781672799915e-14 / 3.5651532383955547e-13 / 2.396709082503607e-12 / 5.521480171031492e-10 / 1.2559804874872373e-08 / 2.0783114956254993e-07 / 4.311397020221965e-08 / 2.2998188297812e 5.132866263479021e-07 / 2.0389575690868755e-07	0.013874385	12
4	S100A11_1	0.0000007141	0.0002735997430699673 / 0.006564850275482538 / 0.00042414739039363294 / 0.029067524880234556 / 0.0227837453875734 / 0.0013348733587389963 / 0.025661191456139584 / 0.030326580226023813 / 0.01355699403064558 / 0.004313726310163241 / 0.0095400572561103 / 0.04535245314863	6.393329432968863e-16 / 1.2307435361378187e-13 / 2.466858890049804e-13 / 5.545342625838226e-09 / 1.0380326612394311e-08 / 2.3437239888960063e-09 / 1.3417028235666536e-07 / 4.443975040006529e-07 / 9.063384713333984e-07 / 1.1118101978 2.049520010016173e-06 / 4.414454919747786e-06	0.015766646	12
5	TMEM92_2	0.0000000001	8.127905920870596e-06 / 0.03825717382100051 / 0.03457460632857845 / 0.004853137512524773 / 0.03388689864411195 / 0.008814758212945951 / 0.03578088316319923 / 0.006217130934294085 / 0.00017355910676635736 / 0.0280335961707743 / 0.0017388474926662016 / 0.000124608308510	2.4261531255663892e-11 / 5.0311269179717914e-11 / 2.4975316917871734e-10 / 2.042638151066576e-07 / 1.5566664880019958e-10 / 5.680894385767319e-06 / 1.6699000588343938e-06 / 6.566036837900111e-06 / 3.420597261413642e-07 / 8.237906153 9.263610563311242e-07 / 1.2428063696083114e-06	0.016038611	12
6	ATP6V0B_1	0.0000017465	0.00016551876926533193 / 0.015335407229032524 / 0.0076626373197674 / 0.028777417252359768 / 0.026082796942956787 / 0.0389316131443371 / 0.0004915314263603532 / 0.0014839424825817675 / 0.022837697585243923 / 0.01178531426696526 / 0.00988329756179177 / 0.0317276252166644	2.401602140750141e-13 / 4.8650677089433124e-11 / 3.9493836034696935e-10 / 7.33482261725945e-09 / 2.8535418288695915e-08 / 2.096326058421669e-09 / 1.5659535702420375e-08 / 3.964614244828257e-07 / 1.7237698783914587e-07 / 3.2415943673 6.164017172502494e-08 / 3.4316628105398186e-07	0.016263733	12
7	GBP1_1	0.0000405829	0.04015481753439807 / 0.018576825788521975 / 0.01852560134227437 / 0.002373869363376313 / 0.02782754766981264 / 0.002415619395480455 / 0.011881237105466349 / 0.00033563208340305035 / 0.005055991739999371 / 0.008903270762925434	1.187415764241114e-11 / 6.095615889440819e-11 / 1.917288218821707e-12 / 5.619391245841771e-08 / 1.1719944005143196e-08 / 1.0794280052002033e-07 / 5.9596304962709845e-08 / 0.0004931619081689741 / 9.495988028273389e-08 / 1.166692939780	0.013605041	10
8	ERLEC1_1	0.0000005719	3.075536174342061e-06 / 0.012665982332335715 / 2.1913337236976437e-05 / 7.482707136703458e-05 / 2.6075431224558473e-05 / 5.690512097896811e-05 / 0.0020110917770508187 / 0.0009108241993284896 / 9.402887850421925e-06	8.155050086866359e-08 / 8.547376478456365e-07 / 4.650557832871856e-07 / 1.979425060398104e-07 / 9.659100942891217e-07 / 1.5727836576660756e-05 / 2.4902482384647638e-06 / 5.963679135141154e-06 / 0.0002870787007736368	0.001753344	9
9	SSH3_1	0.0000007635	0.0035447981156988204 / 0.0020476470911988563 / 0.0043734414976099745 / 0.00442890244448457 / 0.0016646475834734644 / 0.003469684588834184 / 0.016258281480713958 / 0.007203498668728194 / 0.008481086009715616	1.2839817776716313e-11 / 2.1456295745112202e-09 / 7.804965919854057e-11 / 1.0846113597262452e-10 / 8.402308355591066e-09 / 4.0629325207940226e-07 / 3.407462995284017e-05 / 4.726367578576213e-06 / 2.5541465321521183e-06	0.00571911	9
10	TRIP10_1	0.0000173218	0.008943680317061822 / 0.0013412546793620756 / 0.0015773645986452735 / 0.007477694270383053 / 0.03117319702966703 / 0.03615921936711382 / 0.0031899243253359325 / 0.01485798676987582 / 0.03709204807398679	2.967675338863489e-16 / 1.3369912839925863e-16 / 9.67218561771649e-13 / 1.6290794365229653e-10 / 7.687956044278108e-10 / 4.534964360985728e-09 / 5.405201490429158e-09 / 7.483583479891572e-09 / 6.363635419128828e-06	0.01575693	9
11	MAN1B1_5	0.0000014304	0.0023856498203327875 / 7.812266726494329e-05 / 0.027952944492863622 / 0.005617959119750928 / 0.002644793270745064 / 0.012381465875087235 / 0.0074542403283965625 / 0.001546432706758083	1.868937111544232e-10 / 1.6531442166915098e-08 / 9.414450468098132e-09 / 7.030425208487326e-08 / 4.773344609707843e-08 / 3.1813403816802826e-08 / 1.2054478070790373e-06 / 5.5556733765270095e-06	0.007507701	8
12	CD151_2	0.0000016613	0.002828971924250992 / 0.0020308786555996105 / 0.0037139272628794475 / 0.0008147078915095311 / 0.0027987535750038264 / 0.03156448872153919 / 0.006216893575679977 / 0.012774860953989628	1.3495328256839188e-12 / 1.6512296821172123e-12 / 3.6414648280531383e-13 / 2.006846342245524e-10 / 9.201808809340132e-08 / 5.931180856539697e-07 / 3.000290377999784e-07 / 5.940973440824346e-07	0.007842935	8
13	PDLIM7_1	0.0000151792	0.0017419308016053887 / 0.01703591045996455 / 0.010263742478054323 / 0.0074877120166343125 / 0.003951752871247063 / 0.023461658690951844 / 0.0007060714810871347 / 0.00993017974219656	1.4890466266195927e-09 / 1.3930872632280484e-10 / 4.042121027066677e-08 / 5.515991658674008e-07 / 3.206759648352692e-09 / 7.38168534365637e-08 / 1.2279749259117268e-08 / 1.6868345203620706e-07	0.00932237	8
14	GLIPR1_1	0.0000014611	0.008133825444941598 / 0.0005214752415830771 / 0.01773178574837757 / 0.009430350367584172 / 0.01955380058568292 / 0.003589646250229098 / 0.0015918099299812008 / 0.021268808314233105	1.4019555545362636e-10 / 1.3355121304727163e-10 / 5.96825464847569e-10 / 7.437295967997082e-09 / 2.751586429438836e-09 / 5.123469233147485e-08 / 4.827912592803016e-07 / 9.24174412768079e-06	0.010227688	8
15	GPR87_1	0.0000006448	0.0076251167073391945 / 0.0028222416161458853 / 0.033262979309241485 / 0.0006381430782712855 / 0.0019094505299096247 / 0.018260880298473985 / 0.003923489922251829 / 0.014606068770244599	7.534055709544274e-17 / 2.585655261990035e-15 / 5.2335156402490275e-15 / 2.4905394673635635e-09 / 2.579143491051842e-10 / 3.3024470123206265e-08 / 2.0302747016952384e-07 / 3.115039621495257e-06	0.010381046	8
16	SNAP25_1	0.0000076174	0.0018807133849514282 / 0.0021339409269866432 / 0.008547140700416327 / 0.007837425491160097 / 0.0018204809165742553 / 0.01250093546784304 / 0.029444897497836964 / 0.025484654242891817	1.4208036186314184e-16 / 1.5507536243084707e-13 / 1.696952191969015e-11 / 1.009604302429168e-09 / 1.0410206618966501e-09 / 1.850497353460836e-09 / 1.0634082068029867e-08 / 1.0722107820456968e-07	0.011206274	8
17	FGFBP1_2	0.0000000001	0.00017601864871485512 / 0.0005070210241593581 / 0.004411629733717425 / 0.008689109920315017 / 0.00019506735122442717 / 0.009640097626965513 / 0.006852417553255793	1.9060720081271283e-13 / 3.122850645863472e-09 / 4.1994336271257894e-10 / 6.0155643158720954e-09 / 3.843362175544889e-08 / 8.712480724022447e-06 / 1.9248384673484406e-07	0.004353052	7
18	CHN1_1	0.0000025565	0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 / 0.001533522936452515 / 0.0033634941504627697 / 0.010785244262186303 / 0.0373128898832142	6.175453097411747e-15 / 1.0898537184801719e-12 / 4.243100156030503e-12 / 2.3893328777750658e-08 / 3.7113695617625286e-08 / 1.3950404315566743e-06 / 4.353340320251518e-07	0.009175484	7
19	ACSF2_4	0.0000126680	0.002287441661560721 / 0.002739732144211229 / 0.010839213238666172 / 0.02699935544242534 / 0.006587582753649601 / 0.020104758213330888 / 0.0037867420062336647	1.6018264558328353e-11 / 1.350522100376996e-10 / 3.533719025417417e-08 / 9.421341247634894e-07 / 6.358471973834479e-06 / 0.0005708652264651822 / 2.8573976842147612e-05	0.010477832	7
20	SNAPC3_1	0.0000014845	0.003808062774578335 / 0.03330161757206289 / 0.001267397044740127 / 0.025490833026200553 / 0.005752102707973715 / 0.010531169902390105 / 0.02097227539629169	4.138352317586387e-12 / 6.324952413663082e-12 / 2.3039595587795142e-11 / 4.135749382360492e-09 / 2.943942798609411e-09 / 4.785025404402047e-07 / 8.45468021727955e-07	0.014446208	7
21	ZFP82_1	0.0000002911	0.026193133649308403 / 0.002880197932827539 / 0.000892065314189748 / 0.03621760269335816 / 0.001409066709832824 / 0.03632632282612366 / 0.001597966657771602	2.1821058503470977e-07 / 2.1345284484994668e-07 / 1.6940360882868594e-06 / 2.332116712137168e-06 / 7.078139307433867e-06 / 4.932653487474453e-06 / 5.57905665828971e-06	0.015073765	7
22	OPHN1_1	0.0002612099	0.04894666674267963 / 0.003544372498506248 / 0.03445218818410945 / 0.029417648259261447 / 0.01144054174070861 / 0.030599292085887794 / 0.003150128220025032	2.2816161503286945e-09 / 5.483877356966662e-07 / 6.645530643543907e-07 / 1.1508399694576279e-07 / 2.1220867950204813e-06 / 1.0055030736784958e-05 / 8.336038812610863e-05	0.023078691	7
23	TNS3_1	0.0000006277	0.009569659528755218 / 0.0013302955859364471 / 0.0037548210952919408 / 0.0024792131341982242 / 0.003608716025393357 / 0.002638008434399487	8.722976186020636e-08 / 1.7164630812419945e-08 / 1.770632094332526e-08 / 1.9486556735289747e-07 / 4.0623560474101545e-07 / 5.860863385843348e-07	0.003896786	6
24	P2RY6_5	0.0000010436	0.0009804545262469449 / 0.0013446510229950341 / 0.003789065107490644 / 0.006218322225340153 / 0.03645229771138508 / 0.01562975702849699	1.576709465685621e-13 / 2.5331252718662176e-10 / 2.3521007770880894e-07 / 2.3770553645092087e-10 / 1.368096065972398e-07 / 2.5418800842381177e-07	0.010735758	6
25	SCO2_3	0.0000000001	0.01546077257784758 / 0.001964618656338199 / 0.0033965914999294854 / 0.012145502525993949 / 0.030055718710212946 / 0.013950769826858294	8.014599938246778e-09 / 1.8636695061114395e-08 / 3.705794897358954e-08 / 4.2936074352856663e-07 / 5.584053250118188e-05 / 2.397206724754045e-07	0.012828996	6
26	KHSRP_1	0.0000003011	0.010352775099646664 / 0.019182484865138457 / 0.015100022601522628 / 0.01700255170966236 / 0.023101003520372643 / 0.006776149448547382	2.8490498620729386e-09 / 5.206538616416615e-10 / 1.4824605802962609e-08 / 7.704856226971619e-07 / 5.512137468127689e-07 / 3.2143315687611383e-06	0.015252498	6
27	TTC3_1	0.0000002043	0.021976203067763718 / 0.014404186233262522 / 0.010065328958198384 / 0.005185630347493037 / 0.01771094219397329 / 0.026010950792548747	1.903714561147216e-10 / 1.8998104659295357e-09 / 8.134060967771899e-10 / 7.905696358239668e-09 / 1.7016664284191773e-06 / 2.3041895625093597e-07	0.015892207	6
28	STEAP1_1	0.0000029634	0.013036283678806082 / 0.015688398206555057 / 0.006349160970663491 / 0.03777942745740614 / 0.010550376036332488 / 0.017877825906191358	6.761435756061347e-12 / 2.4207465935628376e-11 / 3.564533224675541e-12 / 4.401553310565403e-08 / 1.2935469598692122e-07 / 1.118837878226449e-05	0.016880245	6
29	RNF207_2	0.0000000000	0.010918237443275771 / 0.010043999800272532 / 0.007055519329675997 / 0.027127865042923947 / 0.036896549219609824 / 0.015551929442979676	2.026443768844747e-13 / 1.0452530817759512e-11 / 3.4953412148396826e-12 / 2.417587221451319e-08 / 4.833952724825644e-07 / 6.916720467647325e-07	0.01793235	6
30	C16orf59_2	0.0000011638	0.0017105849166402373 / 0.008006011161483364 / 2.877198249929341e-05 / 0.00044269902702600075 / 0.0035960656357070827	8.710873698386588e-07 / 1.6466535184566052e-06 / 3.1826237601737307e-06 / 1.5852069704631895e-05 / 5.3568783395819636e-05	0.002756827	5
31	ICAM1_1	0.0000008958	0.0006371740222421855 / 0.0004238045362036801 / 0.004627658102704232 / 0.0017187301776334363 / 0.0141342657951169	5.301958232122965e-10 / 5.691310460319534e-10 / 9.501545566679268e-08 / 7.484161653079297e-07 / 1.0741352344507851e-05	0.004308327	5
32	POLE_1	0.0000006233	0.00020876871631167866 / 1.4383640936438872e-05 / 0.010067369603256736 / 0.012703084299864359 / 0.0035305946391629545	4.564149862726603e-11 / 4.031853969284765e-09 / 2.1715096143998947e-09 / 5.185675527716179e-08 / 9.417769469553245e-08	0.00530484	5
33	MYT1_3	0.0000018757	0.0003180382059133217 / 0.008006011161483364 / 2.877198249929341e-05 / 0.022477574071905464 / 0.002087164867003088	1.3185457834679754e-09 / 1.0046430313676016e-07 / 8.61285349137364e-07 / 5.400726736519221e-07 / 1.926503424303301e-05	0.006583512	5
34	MMRN2_1	0.0000020377	0.0006381430782712855 / 0.0028222416161458853 / 0.0076251167073391945 / 0.003923489922251829 / 0.033262979309241485	1.858452443514514e-05 / 1.5622701951466016e-05 / 3.730943185783191e-05 / 0.0001274335060935434 / 0.0007602117674326636	0.009654394	5
35	ZNF420_1	0.0000000763	0.00765254728362311 / 0.02761664002677436 / 0.005704138976540187 / 0.0062144909889472 / 0.02210665467937813	2.2557919455927213e-08 / 3.8434441624955556e-08 / 4.143652073206543e-08 / 8.451473540512692e-07 / 4.161971954576053e-06	0.013858894	5
36	ELOVL1_2	0.0000041883	0.005612639115469282 / 0.004888298105885152 / 0.008969805039998042 / 0.030404112516122277 / 0.03243772518292004	3.522904480656644e-10 / 4.32348036263409e-10 / 1.2293459738289953e-08 / 1.8913948776318332e-08 / 2.54997287465458e-07	0.016462516	5
37	CHGB_1	0.0000004668	0.01797077169605779 / 0.01038558151359997 / 0.03995334833105726 / 0.001300447845463061 / 0.02829515218286432	1.9938343577981134e-14 / 2.978187999752288e-14 / 0.0001540200268173068 / 6.798337935097158e-05 / 2.4772197524644612e-08	0.01958106	5
38	MLKL_1	0.0000005037	0.04557109838009256 / 0.020065293234851133 / 0.018782542562548483 / 0.0028710845896819668 / 0.0151749944268713	5.258350011749314e-16 / 3.5233765431361435e-16 / 1.4380692845318856e-14 / 1.6150676172067693e-09 / 2.4525625560555298e-05	0.020493003	5
39	FEZ2_1	0.0000017550	0.031477193589555245 / 0.024379882961236787 / 0.010048470855366752 / 0.011748468267345573 / 0.03714879584420702	6.312935617277429e-10 / 3.7842287030008046e-08 / 2.4657689745274255e-07 / 3.08973568823383e-07 / 2.749086098138227e-07	0.022960562	5
40	ADNP2_1	0.0000001922	0.0026926894174448815 / 0.004075435458657517 / 0.0019491268114425514 / 0.001327102464026624	1.2225480672529466e-06 / 3.0317781765339874e-07 / 5.119644519453932e-07 / 6.547354475139775e-07	0.002511089	4
41	CES2_1	0.0000000854	0.0011256917008427522 / 0.00029984671915346143 / 0.0069928898567800275 / 0.0037176072866771754	5.386350021831899e-08 / 4.097431696633607e-08 / 3.300361146039448e-07 / 2.3865798857407134e-08	0.003034009	4
42	DDR1_2	0.0000037846	0.005811854132542747 / 0.00015027886843801155 / 0.015373655199800797 / 0.010222251543950407	1.3359340041312337e-07 / 0.0004586184985847102 / 3.181191463640303e-05 / 2.4848821642062066e-05	0.00788951	4
43	PTGR1_1	0.0001294867	0.000974029004631184 / 0.010347970561211065 / 0.0033011167578337673 / 0.017006970232444858	3.75794293906824e-10 / 2.742804006281166e-10 / 6.771606681956264e-10 / 4.371488301831706e-09	0.007907522	4
44	LIN7A_1	0.0000001378	0.0003053911694309243 / 0.0008478272697591876 / 0.02960036890335299 / 0.00505471841056208	6.44051592787778e-15 / 1.6309672669483183e-12 / 5.867966338897064e-09 / 9.118314699470778e-11	0.008952076	4
45	SYNCRIP_1	0.0000002054	0.00032880733436267256 / 0.011951324766386422 / 0.0027159743199694653 / 0.02902955003102947	3.348316142238797e-07 / 1.9514280045818426e-06 / 2.6301830086705713e-07 / 7.532993598712855e-08	0.011006414	4
46	EREG_1	0.0000004009	0.013036283678806082 / 0.015688398206555057 / 0.010550376036332488 / 0.006349160970663491	3.9566088865499e-12 / 3.2858827273117755e-10 / 7.373790642942721e-08 / 1.7082322019514156e-10	0.011406055	4
47	C12orf57_1	0.0000023046	0.028957927563687466 / 0.010155427409165514 / 0.002911658631725467 / 0.01482122652336213	5.418786155576515e-08 / 9.894747993886977e-09 / 1.0898528564578497e-05 / 9.693695439206281e-06	0.01421156	4
48	PARP9_1	0.0000003928	0.014588245785000514 / 0.004624429303044866 / 0.027918024199514987 / 0.010739324225736034	1.0885372638586847e-06 / 2.7399829900956533e-05 / 1.1332635442176465e-05 / 0.0019394426591983717	0.014467506	4
49	SLITRK3_1	0.0000015095	0.008527348662485085 / 0.005576784085290364 / 0.03856475377208919 / 0.017395831116316804	4.879058800869575e-10 / 6.089275055540338e-08 / 8.719955641574723e-08 / 1.2488572217128136e-07	0.017516179	4
50	BIRC7_2	0.0000002867	0.007821970573183347 / 0.012845369111074686 / 0.031890899198805917 / 0.02364396066164544	1.415313199875648e-06 / 1.6775105441448168e-06 / 2.9271097438840027e-06 / 4.809721198171681e-07	0.01905055	4
51	ID4_1	0.0000000438	0.003637438547469328 / 0.0035281538483017986 / 0.03136639803264472 / 0.038599008286505046	4.0717260162829775e-06 / 6.566951490305026e-08 / 3.5276667485857833e-07 / 7.44565437001132e-08	0.01928275	4
52	NUCB2_1	0.0000017255	0.015046780105136083 / 0.0032323812044334427 / 0.04240343926485064 / 0.017505946985290035	8.68516823257589e-12 / 1.202306983296894e-07 / 1.0709464975577815e-07 / 3.127569243193228e-07	0.019547137	4
53	PDLIM1_2	0.0000001037	0.015202424481940903 / 0.012748370693134645 / 0.04063751247586265 / 0.022091540973998933	3.14173143142748e-08 / 3.6190255834565276e-06 / 3.7940179795671547e-06 / 4.77087797249951e-05	0.022669962	4
54	RNF219_3	0.0000000003	0.02634863692985202 / 0.03450099983593556 / 0.03513681089329 / 0.015137129753690677	7.261409909964612e-07 / 8.200694456053606e-07 / 4.0053825877934606e-07 / 8.023087556208056e-05	0.027780894	4
55	CTRB2_1	0.0002930973	0.020496866256864702 / 0.028972592148966015 / 0.032049126216131416 / 0.03681214620084693	1.3405501486551371e-06 / 6.226524992191516e-06 / 1.1541305382124772e-05 / 0.003046643299819599	0.029582683	4
56	RAB31_2	0.0000000104	0.006725175164160767 / 0.048022618740457663 / 0.04103625170396066 / 0.04997722883556261	8.150539694234232e-13 / 2.883168259855219e-11 / 1.4028815753928321e-09 / 3.0146813286497465e-07	0.036440319	4
57	INADL_2	0.0000000214	0.0001704720932348638 / 0.001471900435167172 / 0.002014853091681951	0.00015166172573858843 / 6.189932841020127e-05 / 0.0012577263128842932	0.001219075	3
58	DPYSL4_5	0.0000005775	0.0014690065976330497 / 0.00012135998144774518 / 0.002693760101625894	4.6411634719532725e-08 / 2.317754511202282e-05 / 4.294994611664571e-05	0.001428042	3
59	TMEM71_1	0.0000627736	0.004627658102704232 / 0.0006371740222421855 / 0.0004238045362036801	1.0813921624882114e-08 / 2.619185841833522e-07 / 1.5188016611726219e-06	0.001896212	3
60	TPD52L2_1	0.0000003037	0.000823176823593811 / 0.0007924860430472411 / 0.004187597686372937	3.758054827561048e-09 / 6.425156679903907e-10 / 1.2757355615837679e-08	0.00193442	3
61	PDIA3_2	0.0000000000	5.0723783667581744e-05 / 0.009226267029946443 / 0.0017778259882067805	4.9831579429374996e-06 / 1.3486634691146526e-07 / 1.5338596718321366e-05	0.003684939	3
62	KCNK6_1	0.0000030974	0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066	2.061544572083878e-08 / 3.896450174169792e-08 / 5.769947340059933e-08	0.003744412	3
63	CASP8AP2_2	0.0000000219	0.007099092180854751 / 0.0001545053835362215 / 0.00595076253249461	2.3414789029943654e-08 / 6.895486056880935e-08 / 3.937778269227827e-06	0.004401453	3
64	LIG1_2	0.0000029926	0.00035665903643679 / 2.5410658402422594e-05 / 0.014175997822512453	2.1508604917775794e-09 / 1.880923327455265e-08 / 1.4976701341341075e-07	0.004852689	3
65	ARVCF_1	0.0000000809	0.001267397044740127 / 0.003808062774578335 / 0.01865963988831641	3.633196454799821e-07 / 1.9057080324447833e-06 / 7.799389653993747e-07	0.0079117	3
66	PPP1R13L_1	0.0000006399	0.026512261541912406 / 8.131569425129391e-05 / 1.125309447182209e-05	2.5138651999817746e-07 / 6.409504618492529e-08 / 2.5997819819707715e-07	0.008868277	3
67	ELL2_1	0.0000000404	0.0018371780594793963 / 0.02029407943779478 / 0.005548792280102234	2.455332869218628e-08 / 3.107620037340903e-07 / 5.894237364187611e-06	0.009226683	3
68	TMEM74_1	0.0000000714	0.01038558151359997 / 0.01797077169605779 / 0.001300447845463061	1.1935648767376756e-12 / 3.737531077554552e-12 / 0.00012280075259138036	0.0098856	3
69	SH3KBP1_1	0.0000012067	0.012901388332189151 / 0.011880485771633283 / 0.005801481063585688	5.030397982975877e-06 / 9.894710679501381e-06 / 3.451000359467373e-05	0.010194452	3
70	AGXT2L2_4	0.0000000778	0.000513024270655123 / 0.030480389193308928 / 3.516928306401037e-05	1.0557144142948509e-10 / 9.649265913114177e-08 / 2.335866075829399e-06	0.010342861	3
71	FLNA_1	0.0006415808	0.02547058360769006 / 0.007922064339996648 / 0.0028656541081260025	2.1400622545568232e-11 / 9.470548049612122e-08 / 4.4822333426382254e-07	0.012086101	3
72	EVPL_1	0.0000007816	0.029829074750389078 / 0.0017371710506312126 / 0.008885340407261452	1.5237448098566468e-14 / 3.468917372397795e-07 / 8.845088917447386e-07	0.013483862	3
73	ITPRIPL1_1	0.0000009682	0.008791850806005239 / 0.005999339290583331 / 0.02786434125186579	1.870754955730307e-08 / 2.8287486016651227e-07 / 2.360872288601893e-06	0.01421851	3
74	MFSD5_3	0.0000006508	0.03071092956608319 / 0.003938218615229689 / 0.008114190972116433	1.5496424572725938e-08 / 3.2554288938109525e-07 / 1.0112718240540003e-07	0.014254446	3
75	IL31RA_1	0.0002445888	0.02204380039340295 / 0.0012839803246042464 / 0.02580532183784653	3.674619339449928e-07 / 4.43344243632212e-07 / 1.71578946301816e-07	0.016377701	3
76	PTP4A3_1	0.0000314449	0.020414472805311466 / 0.0014693336498995695 / 0.028891732420473607	4.776201023875552e-11 / 1.3766382593509082e-07 / 2.9989438068961905e-07	0.01692518	3
77	MMP14_1	0.0002190770	0.04352684110019303 / 0.004148689189670186 / 0.007178678169977374	7.605828771352425e-12 / 1.360797271795892e-07 / 5.390408897387927e-06	0.018284736	3
78	CAND2_3	0.0000026658	0.028895401482093127 / 0.0009805310391307427 / 0.027607746587453963	1.9907164721328134e-09 / 1.290177089971291e-07 / 1.422741749737834e-07	0.019161226	3
79	ZNF292_5	0.0000000002	0.015104769480539766 / 0.026666883622270408 / 0.017197326894837075	4.1769031641265797e-11 / 1.3947688771774266e-09 / 6.03866098049317e-10	0.019656327	3
80	EPSTI1_1	0.0000073158	0.021559234330291194 / 0.018300289055475042 / 0.02003497685558975	1.6504093087898275e-06 / 3.9975165582205597e-05 / 0.0030284224519400325	0.019964833	3
81	CD97_5	0.0000002610	0.0038275409770200564 / 0.019102004865160463 / 0.037465966805106755	3.7683675686710715e-11 / 9.765240850418052e-10 / 9.834582681938526e-09	0.020131838	3
82	POLE4_5	0.0000000093	0.043632422318038745 / 0.0070119701213412116 / 0.014099632537537078	8.269976083603455e-08 / 5.714696518125464e-08 / 1.8209465254324085e-07	0.021581342	3
83	ZDHHC5_2	0.0009125715	0.029337781272574574 / 0.010806162088221837 / 0.028710223635555462	2.0943141147316446e-08 / 5.3448156529365833e-08 / 1.3376144680099656e-06	0.022951389	3
84	CAV1_1	0.0000013507	0.026222968344836436 / 0.006833233979899956 / 0.03977242799449647	3.7284098504062e-09 / 1.981682163269309e-06 / 3.7034676836929953e-06	0.02427621	3
85	PRDM15_1	0.0000000097	0.005780178191260254 / 0.0347977957945877 / 0.03765009109633616	4.1060665120296455e-08 / 1.8022427394306964e-06 / 1.2329107436658844e-06	0.026076022	3
86	TXNL4A_1	0.0000015245	0.022383216654320942 / 0.019379827420147825 / 0.04981058007691468	1.0003973542061314e-07 / 8.318120908222264e-07 / 1.8197652803291898e-07	0.030524541	3
87	PITX1_1	0.0000080593	0.022158530235155818 / 0.031511227848390264 / 0.04273165395476099	4.328726238704806e-08 / 4.785592074987919e-06 / 4.026072305691093e-05	0.032133804	3
88	CDCA5_1	0.0000010967	0.00020876871631167866 / 1.4383640936438872e-05	3.9804264133636086e-05 / 7.242291833169782e-06	0.000111576	2
89	S100A8_1	0.0000173360	0.00032665136423885464 / 0.001217467053354236	6.539606399624481e-07 / 3.473013871109409e-05	0.000772059	2
90	ZNF345_2	0.0000000001	0.0027538076156700553 / 0.0004164659422400142	5.581451003007147e-05 / 2.582604692500973e-05	0.001585137	2
91	CXXC1_2	0.0000000039	0.0037862695623801213 / 0.0005840830556010548	5.223754637766254e-09 / 5.323504510648734e-08	0.002185176	2
92	ANO4_1	0.0000001136	0.004075435458657517 / 0.001327102464026624	3.235805354734205e-09 / 2.3414451573295386e-08	0.002701269	2
93	STAG2_1	0.0000009873	0.0009656381268940972 / 0.004460012570027854	1.0115034206791287e-06 / 5.753841279635619e-06	0.002712825	2
94	PBX4_1	0.0000007099	0.0037817634953029654 / 0.004617838797443333	2.7021040256543387e-08 / 9.484222614246193e-06	0.004199801	2
95	RRM1_1	0.0000018281	0.00020876871631167866 / 0.010067369603256736	2.998747278117476e-12 / 3.3209239192147915e-07	0.005138069	2
96	NUPL1_2	0.0000000000	0.00041289281227492434 / 0.011652453812603707	1.0657713091915916e-05 / 1.3751517277887033e-05	0.006032673	2
97	MCFD2_2	0.0000002619	0.011150109007006106 / 0.0014577507615148278	2.5410316626468867e-07 / 2.943498549327363e-07	0.00630393	2
98	IKBKAP_1	0.0000058887	0.012665982332335715 / 0.00011000641224999337	1.37456436935247e-06 / 3.934205458402021e-07	0.006387994	2
99	KHK_2	0.0000008186	0.00035665903643679 / 0.014175997822512453	1.4320134905312087e-10 / 9.941441418824106e-06	0.007266328	2
100	SEMA4B_1	0.0000003052	0.0015843420398457381 / 0.015326901145981139	1.468853625012769e-07 / 6.70265240601655e-08	0.008455622	2
101	CEP41_1	0.0000001044	0.002099065390574213 / 0.015250218982745749	1.5608353601998867e-06 / 2.2562783101267498e-06	0.008674642	2
102	DTX3L_1	0.0000012287	0.014588245785000514 / 0.004624429303044866	4.3810913690562183e-07 / 1.043509176420455e-05	0.009606338	2
103	SMC2_1	0.0028804091	0.013707617481622131 / 0.006160764737320071	2.8848576349790795e-08 / 3.01310962529332e-06	0.009934191	2
104	HDAC6_1	0.0009422566	0.010972403654712403 / 0.009810990348338811	1.4716710804724593e-08 / 1.7471497758357106e-07	0.010391697	2
105	KDM3A_1	0.0000075561	0.006171913156047586 / 0.014901187095494001	9.834101497765351e-06 / 2.6427885077789545e-05	0.01053655	2
106	DCAKD_1	0.0000000370	0.0018371780594793963 / 0.02029407943779478	2.2436458658220796e-06 / 3.459304592667202e-06	0.011065629	2
107	DUSP5_1	0.0000000812	0.0018371780594793963 / 0.02029407943779478	8.010663169482405e-08 / 1.019028088460542e-05	0.011065629	2
108	PRPF40A_2	0.0000001288	0.014088198537650237 / 0.008403090707899564	5.6662577214788655e-06 / 5.296682535807921e-06	0.011245645	2
109	PPIB_4	0.0000014621	0.0009023360158888423 / 0.024925919514816482	4.368833166819811e-08 / 1.5361134806777145e-05	0.012914128	2
110	ERAP2_2	0.0000000000	0.012146048132262622 / 0.016053861578409306	8.639554915354646e-08 / 3.070087173430692e-07	0.014099955	2
111	BAALC_1	0.0000002690	0.01038558151359997 / 0.01797077169605779	1.6931423038276145e-08 / 1.1971112083511357e-08	0.014178177	2
112	CACNA2D2_1	0.0000006401	0.01038558151359997 / 0.01797077169605779	3.602719217532972e-10 / 4.92697188032859e-10	0.014178177	2
113	CNPY4_1	0.0000002878	0.013815890119720394 / 0.014734308310181646	1.4477884917386144e-08 / 1.2870154644475552e-06	0.014275099	2
114	ANO5_1	0.0000004289	0.01945182673395856 / 0.010144750097293938	1.0116195313294412e-06 / 1.0659601228586417e-07	0.014798288	2
115	KLK6_2	0.0000031514	0.010648596334043373 / 0.01921308313009029	6.133714219132002e-07 / 2.6008835809083705e-06	0.01493084	2
116	TNIP2_1	0.0000070282	0.026512261541912406 / 0.0034616019934828575	1.2306882876630733e-08 / 9.976408891048964e-06	0.014986932	2
117	KCNJ11_4	0.0000008906	0.000513024270655123 / 0.030480389193308928	9.976114533861802e-12 / 1.3939033644956155e-06	0.015496707	2
118	MED14_1	0.0000001777	0.002121580446747506 / 0.02895588272033544	7.223100165739173e-08 / 5.7035521946275234e-06	0.015538732	2
119	PDGFC_3	0.0000264872	0.019513649031375167 / 0.01309714342199912	6.270077252140188e-07 / 9.870611279741555e-05	0.016305396	2
120	SLFN12_2	0.0000134765	0.02168635011054641 / 0.01167533043285143	1.966242069154016e-09 / 3.0933346339022715e-08	0.01668084	2
121	PDP1_5	0.0000352407	0.026311459966079555 / 0.007838360079130574	4.024957504543219e-05 / 1.4145520941653468e-05	0.01707491	2
122	IER5L_1	0.0000221943	0.02740923337273586 / 0.007187884748118219	4.3782241525162567e-08 / 1.83420306508174e-08	0.017298559	2
123	ABCA5_2	0.0000000000	0.026787063397349216 / 0.00879535947608833	1.3685460854987295e-06 / 8.008743570631834e-06	0.017791211	2
124	CABP7_1	0.0000019025	0.027796287019492286 / 0.008385988903950798	5.44509537364398e-08 / 4.285397797391745e-06	0.018091138	2
125	FCRLB_5	0.0000000126	0.029561026010091924 / 0.009477250370701233	8.716818657445855e-09 / 3.812867727785123e-08	0.019519138	2
126	TIGD3_1	0.0000185890	0.004581158169040506 / 0.0362634468993579	1.1724478296921851e-13 / 2.0363624639109813e-05	0.020422303	2
127	ZNF295_1	0.0000305440	0.026753893459817307 / 0.01508657655367455	2.7477807935711586e-07 / 1.7656093493156047e-07	0.020920235	2
128	PLD2_1	0.0000002785	0.027334357885610883 / 0.015006814582667545	6.430412303297122e-07 / 6.394643388050702e-07	0.021170586	2
129	CD55_1	0.0000001511	0.0033161838556922097 / 0.04158968004878196	6.746452037536084e-10 / 2.2063569025007715e-08	0.022452932	2
130	QKI_3	0.0000181952	0.005022174375240862 / 0.042671396636541896	3.032049011104229e-07 / 3.826421197615377e-07	0.023846786	2
131	MZT1_1	0.0000022280	0.0014965558133177162 / 0.046327505690930644	5.073920441583328e-06 / 6.37180443076072e-06	0.023912031	2
132	SEMA7A_1	0.0000140236	0.03342502222700243 / 0.015261311481267638	4.5276764265942424e-06 / 2.6190564781077353e-06	0.024343167	2
133	ROR2_1	0.0000162778	0.02545372903328934 / 0.02593175339775004	5.907585641697503e-08 / 1.241188472253612e-06	0.025692741	2
134	TRIP6_1	0.0000020904	0.038556379049173375 / 0.013202467191346512	2.7542851202738477e-08 / 5.023495130487458e-08	0.025879423	2
135	C14orf142_1	0.0000007942	0.005868270029793827 / 0.046553563135817905	9.376272681986819e-08 / 4.128986695162416e-06	0.026210917	2
136	ZEB1_2	0.0000468499	0.0213162921786289 / 0.0376737496455549	9.176186713429999e-08 / 2.4212534015690606e-05	0.029495021	2
137	NIP7_2	0.0000000218	0.03316581736784557 / 0.0271384576648737	4.075740819100947e-06 / 5.399297858392524e-06	0.030152138	2
138	GNAO1_1	0.0000005231	0.033760894472022615 / 0.026780216732580863	1.499270713634952e-09 / 1.217458355445439e-05	0.030270556	2
139	FGF9_1	0.0000005137	0.03951670000167351 / 0.02495147370057548	2.989061419962864e-12 / 1.737392805769214e-09	0.032234087	2
140	SERINC3_1	0.0000008268	0.026334033069056118 / 0.03845067832601619	9.100407986778662e-07 / 3.240588908989103e-07	0.032392356	2
141	RSBN1_1	0.0000010033	0.026040435274654685 / 0.03886956807554024	2.221315610307105e-11 / 9.033061104976416e-08	0.032455002	2
142	ARVCF_1	0.0000002829	0.026222968344836436 / 0.03977242799449647	7.483862897069276e-07 / 5.432934252510295e-07	0.032997698	2
143	DTL_1	0.0000076383	0.039542232891747735 / 0.02707374976179199	3.398617522656201e-09 / 9.59460633791626e-07	0.033307991	2
144	SRSF7_1	0.0000002874	0.0347977957945877 / 0.03765009109633616	6.847127318749837e-07 / 3.116230608631045e-07	0.036223943	2
145	IFIT5_2	0.0004701599	0.0364953120948139 / 0.037232340056821626	4.399782821011542e-06 / 1.7393118846309304e-05	0.036863826	2
146	NARF_1	0.0000022881	0.03953940913634625 / 0.03994379945480948	1.1301210005302875e-08 / 2.133257245226995e-06	0.039741604	2
147	CASP8_1	0.0000198034	0.0464587665387115 / 0.0401631181784738	1.601941993185719e-16 / 2.6864531857041694e-11	0.043310942	2
148	IL17RB_1	0.0000067045	0.04546047598682959 / 0.04334588252631349	3.033905276829337e-08 / 1.0262557517569413e-05	0.044403179	2
149	SLC15A2_1	0.0000014155	5.681660863421172e-05	1.5961846511181405e-05	5.68166E-05	One
150	SAR1B_1	0.0000005513	0.00013784539893700994	6.454907031718106e-06	0.000137845	One
151	TTC1_1	0.0000004017	0.00013784539893700994	2.336682885494787e-10	0.000137845	One
152	CRP_2	0.0000000078	0.00016321344400834376	5.576182275696905e-05	0.000163213	One
153	GGCX_1	0.0000076825	0.00017247402077598097	1.2879118524126266e-07	0.000172474	One
154	SOX9_1	0.0000013296	0.0001839790498817074	7.272296164227475e-06	0.000183979	One
155	DLX5_3	0.0000326962	0.0003180382059133217	4.664951986768726e-07	0.000318038	One
156	SNRNP25_3	0.0000000234	0.0003180382059133217	3.3152672324048814e-05	0.000318038	One
157	UHRF1BP1L_1	0.0000001071	0.000349384308330678	2.1709474268278766e-06	0.000349384	One
158	PAPD4_1	0.0000249556	0.0004361114375544852	1.8113390561602514e-06	0.000436111	One
159	ADAMTS14_1	0.0000437150	0.0005765804746846872	6.590376972707598e-05	0.00057658	One
160	FAT2_1	0.0000012964	0.0006381430782712855	4.603295730722451e-06	0.000638143	One
161	ZNF750_2	0.0000000299	0.0007846622552824629	4.022726992390641e-05	0.000784662	One
162	BTG2_1	0.0000093251	0.0008391695317782487	3.5774320349838873e-07	0.00083917	One
163	PIGB_4	0.0000000787	0.0009023360158888423	2.2878500220993498e-11	0.000902336	One
164	WHAMM_4	0.0000010450	0.0009023360158888423	1.1651758424474298e-06	0.000902336	One
165	PELI2_2	0.0000000141	0.0012894304816227693	8.58480971255917e-08	0.00128943	One
166	RPS5_1	0.0000036423	0.00134963344272631	2.405506994776735e-06	0.001349633	One
167	DALRD3_1	0.0000008658	0.0013670815874214685	1.1128380015615429e-08	0.001367082	One
168	ANKRD22_1	0.0000009306	0.0014573918997663137	3.138691465570034e-07	0.001457392	One
169	AGBL4_5	0.0000001940	0.0014690065976330497	3.7344924411524894e-05	0.001469007	One
170	DCUN1D2_1	0.0000001810	0.0014965558133177162	2.6955640062447783e-06	0.001496556	One
171	RAP2A_1	0.0000043749	0.0014965558133177162	3.643928917883914e-07	0.001496556	One
172	TEX30_1	0.0000077886	0.0014965558133177162	7.322882011832241e-07	0.001496556	One
173	CPNE8_1	0.0000012221	0.0015823634728436365	1.0569424770637742e-11	0.001582363	One
174	IFIT3_1	0.0000007653	0.0015904564617824036	2.30780238404599e-06	0.001590456	One
175	KCNMB2_1	0.0000003403	0.0015904564617824036	1.6585833620905925e-08	0.001590456	One
176	TRIM21_1	0.0000000854	0.0015904564617824036	2.1285881318643393e-08	0.001590456	One
177	NAP1L4_1	0.0000087541	0.0017153185879343034	7.850131843413566e-06	0.001715319	One
178	GALNT3_1	0.0000354752	0.0020476470911988563	2.5573822901107337e-05	0.002047647	One
179	EVL_1	0.0000019885	0.002058130936511972	2.717135803874761e-09	0.002058131	One
180	TSPAN8_1	0.0000003090	0.0021489267613823003	1.017187347139058e-05	0.002148927	One
181	RUNDC3B_1	0.0000041888	0.0024846662085153902	1.016379726019311e-05	0.002484666	One
182	CCDC113_1	0.0000076744	0.0025150135152389474	1.5032272736368673e-06	0.002515014	One
183	PIAS2_2	0.0000001786	0.0025152679462084955	2.2483779303553648e-06	0.002515268	One
184	ALG14_1	0.0000072016	0.0026041641330007506	0.0006233183228222267	0.002604164	One
185	TAF11_1	0.0000009139	0.002687295907204792	0.00012476609977995568	0.002687296	One
186	KCNK9_1	0.0011919577	0.0028046841261304568	1.376632392689302e-07	0.002804684	One
187	LRRC8A_1	0.0000035240	0.0032327742303384166	6.356756636137029e-06	0.003232774	One
188	TMEM151B_1	0.0000007358	0.0032636781607269594	1.8328686422960692e-06	0.003263678	One
189	C10orf76_1	0.0000881113	0.003434642569271992	7.673926087001424e-06	0.003434643	One
190	NXNL2_1	0.0000597168	0.003544372498506248	3.942459986260573e-08	0.003544372	One
191	TCEB3_1	0.0005226535	0.0037150885246972363	0.00024989766039529933	0.003715089	One
192	CPEB2_2	0.0000010060	0.003774743841069769	2.850551586644877e-06	0.003774744	One
193	TUBB_1	0.0000000607	0.0037817634953029654	8.334855345042203e-07	0.003781763	One
194	UBE2H_1	0.0000005261	0.004043548766154216	2.7343581965712453e-07	0.004043549	One
195	TM9SF4_1	0.0000000634	0.004075435458657517	1.208568331650002e-06	0.004075435	One
196	ZNF250_1	0.0001614132	0.004581158169040506	8.906742496574832e-08	0.004581158	One
197	ARSD_1	0.0000007813	0.004617838797443333	4.0431258909202725e-06	0.004617839	One
198	ZBED5_5	0.0000000106	0.005222164163583828	1.6160725995889468e-06	0.005222164	One
199	TEAD3_3	0.0000036458	0.0053872635110084445	4.1927795302166964e-05	0.005387264	One
200	PAICS_1	0.0023017121	0.005473511421368178	0.001803574650219185	0.005473511	One
201	SDSL_1	0.0000016496	0.006403254151390212	7.017651789933182e-08	0.006403254	One
202	SP140L_1	0.0000004574	0.00690906973800756	1.4293392545039821e-08	0.00690907	One
203	VEZF1_1	0.0000006200	0.007512524281614588	4.015799360215652e-07	0.007512524	One
204	TSR2_2	0.0000001115	0.00807009151771129	5.455073735317627e-08	0.008070092	One
205	LRFN5_1	0.0001487507	0.00837748774812484	1.765094200227484e-07	0.008377488	One
206	HMOX1_3	0.0000000049	0.009019901589667713	3.3116226812292643e-07	0.009019902	One
207	OAF_2	0.0000021448	0.010087189185487436	6.611044842333954e-06	0.010087189	One
208	C1orf198_1	0.0047644878	0.01058743988900243	5.33047484084318e-06	0.01058744	One
209	RNF145_1	0.0000015182	0.010685297092225236	3.4948918270211384e-09	0.010685297	One
210	TFDP1_2	0.0000000087	0.011664876607743443	1.0484496266632918e-06	0.011664877	One
211	TRIM33_5	0.0000006448	0.012312852331877405	5.823849535285043e-07	0.012312852	One
212	BRD1_1	0.0000056060	0.012444591121133452	9.00450493226787e-08	0.012444591	One
213	RAB18_1	0.0000000557	0.012469136109983507	7.808669892591835e-06	0.012469136	One
214	DOK6_1	0.0000225131	0.0126479390211753	2.9116700927572027e-07	0.012647939	One
215	TMEM132D_1	0.0000007064	0.014125552794811447	0.00013933215110235875	0.014125553	One
216	RBKS_1	0.0000039408	0.014510361909036783	1.369930658748886e-10	0.014510362	One
217	SDPR_1	0.0000144016	0.015098577756027905	1.2200927403044487e-06	0.015098578	One
218	HADHB_3	0.0000011607	0.015198702702676786	4.67481146425626e-06	0.015198703	One
219	RAB2B_1	0.0000015355	0.015525342789786052	9.240171811293034e-08	0.015525343	One
220	CLSPN_2	0.0015604856	0.015681284994245294	4.787605013931291e-06	0.015681285	One
221	LRCH2_1	0.0000013499	0.016913586137948928	3.239478361523596e-06	0.016913586	One
222	RIC8B_1	0.0000258855	0.018613210669019453	2.5972193291243487e-07	0.018613211	One
223	SNX17_1	0.0000005150	0.0187791714585435	7.832292477544212e-06	0.018779171	One
224	HPS1_3	0.0000193423	0.020032646836294014	2.651724363437782e-08	0.020032647	One
225	TNNT3_1	0.0000037981	0.02003497685558975	0.0024373027878036467	0.020034977	One
226	MPHOSPH9_1	0.0000010033	0.020273128817757814	5.7180542135867475e-06	0.020273129	One
227	PCDH7_1	0.0000026780	0.020321552294661337	1.8717328001192637e-06	0.020321552	One
228	NSL1_1	0.0000025413	0.020596934169840004	1.6439984899784691e-06	0.020596934	One
229	ALG9_1	0.0001111425	0.022935884489828733	1.7377644622722088e-06	0.022935884	One
230	PDE12_1	0.0000004658	0.0233155726865293	1.5807742224423866e-05	0.023315573	One
231	PAPSS2_1	0.0000007706	0.024338654294994898	9.283888609188878e-08	0.024338654	One
232	ZFHX2_1	0.0000004187	0.02464096203134193	2.8806779697573074e-06	0.024640962	One
233	TFG_2	0.0000000179	0.02485916255363959	5.4417829495431724e-05	0.024859163	One
234	IL15RA_1	0.0000004083	0.02498090614719385	2.4652810837821435e-06	0.024980906	One
235	MBTD1_1	0.0000000005	0.02498090614719385	2.476481267971609e-05	0.024980906	One
236	TMPRSS4_1	0.0001737302	0.02527275878591322	4.96032498878352e-07	0.025272759	One
237	APBB1_1	0.0007952642	0.025477899370092264	1.1177566606698288e-07	0.025477899	One
238	MAD2L2_1	0.0000650171	0.025477899370092264	7.015450869623152e-07	0.025477899	One
239	MAP4_1	0.0000021567	0.026512261541912406	5.151370139997939e-07	0.026512262	One
240	GLTP_1	0.0000002645	0.02685009566751369	1.2940153369292968e-05	0.026850096	One
241	CECR2_1	0.0000034126	0.02695039496870006	4.8390480434201144e-06	0.026950395	One
242	RUFY1_1	0.0000299227	0.027256120811697704	8.232591388149916e-11	0.027256121	One
243	LRRN1_3	0.0000000006	0.027852483618169322	2.4617114447232193e-06	0.027852484	One
244	ATRIP_1	0.0000459410	0.028297897669394324	3.581872487568641e-06	0.028297898	One
245	NADKD1_1	0.0001614851	0.030463092594199083	9.476649004029163e-08	0.030463093	One
246	DAPL1_5	0.0000001131	0.03247309026025267	1.063046591606967e-06	0.03247309	One
247	HSD17B10_1	0.0000356915	0.03300637436842342	3.315891641410488e-08	0.033006374	One
248	CTSL1_5	0.0000012024	0.033080135108199266	2.1760418610560375e-10	0.033080135	One
249	PPM1F_2	0.0000003736	0.033564554983805193	6.023420324819565e-06	0.033564555	One
250	SERPINB8_1	0.0000004020	0.03395639101055327	7.590142415124812e-06	0.033956391	One
251	LEPREL4_1	0.0000031108	0.03517044127467462	9.048855093781964e-06	0.035170441	One
252	HIRA_1	0.0000071773	0.036656389092885745	6.41338762201109e-06	0.036656389	One
253	MET_2	0.0000048647	0.03675726542857143	4.0499324464518144e-07	0.036757265	One
254	ST18_2	0.0000003070	0.03675726542857143	2.1367286772341655e-08	0.036757265	One
255	IFI35_1	0.0000001142	0.037485659344956734	1.8673858169252516e-08	0.037485659	One
256	CNKSR3_1	0.0000002224	0.0380562899913768	1.4065162180136549e-05	0.03805629	One
257	NFKBIZ_1	0.0002437797	0.038514781543232596	2.106101897324396e-07	0.038514782	One
258	TFPI_1	0.0050804078	0.038514781543232596	7.186644444797165e-08	0.038514782	One
259	PDIA6_1	0.0000012653	0.038781900239634945	1.1794828467593882e-06	0.0387819	One
260	RSF1_3	0.0000000002	0.03932106882555421	1.1649216389446077e-06	0.039321069	One
261	MYO1E_2	0.0000209873	0.039881619914679374	4.562099888852519e-11	0.03988162	One
262	UBAP1_1	0.0000010913	0.040258840897526606	2.649945837106964e-07	0.040258841	One
263	GFER_1	0.0000199213	0.041058990270996985	1.013140578199153e-06	0.04105899	One
264	C17orf75_1	0.0000001475	0.041863358380761856	2.011957469008045e-05	0.041863358	One
265	TTC9B_1	0.0000199304	0.0440605439544666	1.3515245965925785e-06	0.044060544	One
266	FAM198B_1	0.0000000398	0.04544630802892216	1.2975083762851168e-06	0.045446308	One
267	DCTD_1	0.0000002300	0.045495607074215974	9.613702843960257e-08	0.045495607	One
268	ZSCAN16_1	0.0000002003	0.04907931555044797	6.364155025566868e-08	0.049079316	One
269	CCDC14_2	0.0000000040	0.049412789880137475	1.0956612304568067e-06	0.04941279	One
270	TRIP11_1	0.0000106522	0.049477459520320635	3.616757502303368e-08	0.04947746	One
271	NKAIN2_1	0.0000341788	0.04968678580260802	1.3235403934017564e-06	0.049686786	One
272	NT5E_1	0.0000065065	0.04968678580260802	1.050035169104463e-10	0.049686786	One
273	PPP1R14A_5	0.0000105571	0.00022092891960888485	5.27242603779648e-05	0.000220929	One
274	CDH2_1	0.0001087650	0.0005511270416472728	0.0004028031199308745	0.000551127	One
275	EMC3_1	0.0000000114	0.0006784104611363802	3.0652280007137936e-05	0.00067841	One
276	NCAPG2_1	0.0000228504	0.0007900043500214932	0.0004768223953633258	0.000790004	One
277	OR13H1_2	0.0011906247	0.024195410263062368	0.024770686509726116	0.02419541	One

Table 12 lists the FRHs associated with the sarcoma cancer drug, and the markers defining the sarcoma cancer drugs and FRHs associated therewith.

In addition, [Table 13] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 12].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 12], the reactivity correlation value for each drug is divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug reactivity according to the order of drugs listed in [Table 12], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average value of the calculated values, and『 Rank 』means the number of sarcoma cancer drugs in which the corresponding FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

Meanwhile, in FIG. 35, the correlation values (P-vlaue) of sarcoma cancer drugs of the major biomarkers among the biomarkers listed in Table 12 are graphically displayed, and in FIG. 36, the genes expressed by the main biomarkers Correlation values (P-vlaue) values for the fields and sarcoma cancer drugs are plotted.

Reactive biomarkers for sarcoma cancer drugs

No.	FRH	Drug	DrugType	Var (marker)
One	LUC7L_5	263_FR-180204 / 310_YM201636 / 294_MPS-1-IN-1 / 228_KIN001-102 / 326_GSK690693 / 288_KIN001-055 / 303_PIK-93 / 1498_AZD6244 / 305_TPCA-1 / 271_VNLG / 124 / 245_UNC0638 / 330_XMD13-2 rescreen) / 286_KIN001-236 / 344_THZ-2-49 / 256_JW-7-24-1 / 185_OSI-906 / 304_SB52334 / 265_Tubastatin A / 283_GSK2126458 / 253_XMD14-99 / 346_THZ-2-102-1 / 298_OSI-930 / 257_NPK76- II-72-1 / 1372_Trametinib / 331_QL-X-138 / 1014_RDEA119 / 290_KIN001-260 / 221_TAK-715 / 252_WZ3105 / 276_CAY10603 / 287_KIN001-244 / 306_TG101348 / 179_5-Fluorouracil / 301_Pu 300_CX-5461 / 226_GSK1070916 / 1010_Gefitinib / 281_CH5424802 / 1242_ (5Z) -7-Oxozeaenol / 223_ZSTK474 / 1011_ABT-263 / 292_Masitinib / 1008_Methotrexate / 175_PAC-1 / 299_OSI-762 / 328_SNX-2112 / 254_AC220 / 211_TL-2-105 / 274_Belinostat / 260_NG-25 / 279_BIX02189 / 152_CP466722 / 272_AR-42 / 136_Mitomycin C / 222_BX-912 / 208_SB-715992 / 184_BMS-754807 / 56_WH-4-023 / 1218_JQ1 / 1091_BMS-536924 / 1017_Olaparib / 341_EX-527 / 261_TL-1-85 / 1259_BMN-673 / 1060_PD-0325901 / 205_BMS-708163 / 196_Phenformin / 302 309_Y-39983 / 1020_Lenalidomide / 1005_Cisplatin / 1262_UNC1215 / 329_QL-XI-92 / 1495_Olaparib / 295_NVP-BHG712 / 258_STF-62247 / 200_LAQ824 / 1026_17-AAG / 1039_SL 0101-1 / 260 260 / 235_QL-XII-47 / 203_BMS-345541 / 182_Obatoclax Mesylate / 1012_Vorinostat / 1013_Nilotinib / 1175_AG-014699 / 135_Gemcitabine / 266_Zibotentan / 178_BAY 61-3606 / 332_XMD15-27 / 1264_SGC09 / 1264_SGC	erk_mapk / other / mitosis / pi3k / pi3k / other / pi3k / erk_mapk / other / chromatin / chromatin / other / egfr / erk_mapk / other / cell_cyc / other / igfr / rtk / chromatin / pi3k / rtk / cell_cyc / rtk / mitosis / erk_mapk / other / erk_mapk / other / jnk_p38 / other / chromatin / pi3k / other / DNArep / cell_cyc / chromatin / other / other / mitosis / egfr / rtk / other / pi3k / apop / rtk / DNArep / apop / tor / pi3k / chromatin / mitosis / other / rtk / erk_mapk / chromatin / other / other / g_integrity / chromatin / DNArep / pi3k / mitosis / igfr / abl / chromatin / igfr / g_integrity / other / other / g_integrity / erk_mapk / other / metabol / pi3k / cytoskeleton / other / DNArep / other / rtk / g_integrity / rtk / other / chromatin / other / erk_mapk / egfr / cell_cyc / rtk / metabol / pi3k / other / other / apop / chromatin / abl / g_integrity / DNArep / other / other / other / chromatin / tor / g_integrity / cytoskeleton	1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 5_141432375_A_C / 22_18847351_G_C
2	FZD3_1	228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 223_ZSTK474_2 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 304_SB52334_3 / 224_AS605240_3 / 282_Pelitinib_2 / 253_XMD14-99_3 / 263_FR-180204_3 / 326_GSK690693_3 / 152_CP466722_3 / 225_Genentech Cpd 10_3 / 290_KIN001-260_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 286_KIN001-236_3 / 238_Idelalisib_1 / 299_OSI-027_2 / 272_AR-42_2 / 298_OSI-930_2 / 222_BX-912_3 / 265_Tubastatin A_3 / 275_I-B_I_B_Stable 256_JW-7-24-1_3 / 274_Belinostat_1 / 301_PHA-793887_3 / 219_AT-7519_2 / 303_PIK-93_3 / 252_WZ3105_3 / 329_QL-XI-92_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_9797_ 261_TL-1-85_3 / 211_TL-2-105_3 / 271_VNLG / 124_3	pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk / rtk / pi3k / egfr / rtk / erk_mapk / pi3k / g_integrity / mitosis / other / other / jnk_p38 / other / pi3k / tor / chromatin / rtk / pi3k / chromatin / chromatin / other / chromatin / mitosis / other / other / chromatin / cell_cyc / cell_cyc / pi3k / other / rtk / mitosis / chromatin / igfr / other / other / erk_mapk / chromatin	1_26457907_T_G
3	LMBR1L_3	261_TL-1-85_3 / 281_Alectinib_2 / 291_KIN001-266_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 344_THZ-2-49_3 / 303_PIK-93_3 / 286_KIN001-236_3 / 256_ 1_3 / 328_SNX-2112_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 260_NG-25_3 / 290_KIN001-260_3 / 345_KIN001-270_3 / 208_Ispinesib 305 -138_3 / 225_Genentech Cpd 10_3 / 299_OSI-027_2 / 273_CUDC-101_2 / 276_CAY10603_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 292_Masitinib_1 / 263_FR-180204_3 / 272_AR-42_2	other / rtk / other / cell_cyc / other / mitosis / cell_cyc / pi3k / other / other / other / other / other / pi3k / mitosis / other / other / cell_cyc / mitosis / cell_cyc / other / other / mitosis / tor / chromatin / chromatin / mitosis / chromatin / rtk / erk_mapk / chromatin / g_integrity / pi3k / pi3k	20_35697711_A_C / 7_72949311_A_C / 12_109266204_T_G
4	ACTN2_3	310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 328_SNX-2112_3 / 344_THZ-2-49_3_ 260 2_3 / 256_JW-7-24-1_3 / 245_UNC0638_3 / 252_WZ3105_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 286_KIN001-236_3 / 152_CP466722_3 / 326_GSK690693_3 / 283_Omi_Plato 25_3 / 253_XMD14-99_3 / 226_GSK1070916_2 / 331_QL-X-138_3 / 261_TL-1-85_3 / 279_BIX02189_3 / 223_ZSTK474_2 / 291_KIN001-266_3 / 271_VNLG / 124_3	other / erk_mapk / mitosis / other / pi3k / pi3k / other / other / cell_cyc / other / pi3k / rtk / other / other / chromatin / other / tor / mitosis / other / g_integrity / pi3k / pi3k / cell_cyc / DNArep / other / rtk / mitosis / other / other / other / pi3k / other / chromatin	1_26457907_T_G / 22_18847351_G_C / 22_21127217_C_G
5	UBXN7_2	310_YM201636_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 256_JW-7-24-1_3_3_ / 124_3 / 301_PHA-793887_3 / 185_Linsitinib_2 / 1017_Olaparib_2 / 253_XMD14-99_3 / 136_Mitomycin-C_1 / 1495_Olaparib_1 / 281_Alectinib_2 / 257_NPK76-II-72-1_3 / 292_Masitinib_1 / 1003_Camptothecin_1 / 290_KIN001-260_3 / 298_OSI-930_2 / 283_Omipalisib_2 / 300_CX-5461_3 / 304_SB52334_3 / 273_CUDC-101_2 / 223_ZSTK474_2 / 299_OSI-027_2 / 331_QL-X-138_3	other / g_integrity / cell_cyc / other / other / mitosis / pi3k / erk_mapk / other / chromatin / mitosis / other / pi3k / chromatin / cell_cyc / igfr / g_integrity / rtk / DNArep / g_integrity / rtk / mitosis / rtk / DNArep / other / rtk / pi3k / other / rtk / chromatin / pi3k / tor / other	22_24252424_G_C / 1_26457907_T_G
6	TRAM2_2	226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 299_OSI-027_2 / 228_AKT_inhibitor_VIII_3 / 228_AKT_inhibitor_VIII_3 / 260_AK_3_ 2-102-1_3 / 301_PHA-793887_3 / 222_BX-912_3 / 1259_Talazoparib_3 / 257_NPK76-II-72-1_3 / 283_Omipalisib_2 / 208_Ispinesib Mesylate_2 / 253_XMD14-99_3 / 303_PIK_93_3_39_3_39_3_39 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 225_Genentech Cpd 10_3 / 254_Quizartinib_2 / 265_Tubastatin A_3 / 331_QL-X-138_3	mitosis / other / erk_mapk / other / mitosis / other / other / tor / pi3k / other / jnk_p38 / other / cell_cyc / cell_cyc / pi3k / g_integrity / mitosis / pi3k / mitosis / rtk / pi3k / pi3k / cell_cyc / rtk / pi3k / other / pi3k / pi3k / mitosis / rtk / chromatin / other	1_26457907_T_G / 22_21127217_C_G
7	CDK13_2	326_GSK690693_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 301_PHA-793887_3 / 331_QL-X-138_3 / 228_AKT_inhibitor_V3_3_3_3_3_3_3_3_3_3 295_NVP-BHG712_3 / 279_BIX02189_3 / 256_JW-7-24-1_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 226_GSK1070916_2 / 286_KIN001-236_3 / 290_KIN001-260_3 / 290 027_2 / 282_Pelitinib_2 / 223_ZSTK474_2 / 245_UNC0638_3 / 304_SB52334_3 / 302_PI-103_3 / 253_XMD14-99_3 / 328_SNX-2112_3 / 238_Idelalisib_1	pi3k / other / cell_cyc / other / pi3k / erk_mapk / cell_cyc / other / pi3k / mitosis / other / other / chromatin / rtk / other / other / cell_cyc / other / pi3k / mitosis / other / other / mitosis / tor / egfr / pi3k / chromatin / rtk / pi3k / rtk / other / pi3k	1_26457907_T_G / 22_30937565_T_G
8	BCL11B_3	310_YM201636_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2_ 256_JN II-72-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 299_OSI-027_2 / 276_CAY10603_3 / 245_UNC0638_3 / 326_GSK690693_3 / 152_CP466722_3 / 283_Omipalisib_2 / 273_CUDC-101_2 / 346_THZ-2-102-1_3 / 223_ZSTK474_2 / 274_Belinostat_1 / 304_SB52334_3 / 279_BIX02189_3 / 1259_Talazoparib_3 / 272_AR-42_2 / 286_KIN001-236_3 / 287_KIN001-244_3	other / cell_cyc / other / erk_mapk / other / pi3k / other / mitosis / rtk / other / mitosis / other / mitosis / pi3k / other / tor / chromatin / chromatin / pi3k / g_integrity / pi3k / chromatin / cell_cyc / pi3k / chromatin / rtk / other / g_integrity / chromatin / other / pi3k	1_26457907_T_G / 5_141432375_A_C / 22_22643666_C_G
9	LONRF1_4	344_THZ-2-49_3 / 288_WHI-P97_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 252-7 24-1_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 299_OSI-027_2 / 303_PIK-93_3 / 291_KIN001-266_3 / 279_BIX02189_3 / 346_THZ-2-102-1_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 292_Masitinib_1 / 265_Tubastatin A_3 / 273_CUDC-101_2 / 245_UNC0638_3 / 287_KIN001-244_3 / 152_CP466722_3 / 261_TL-1-85_3 / 208_Ispinesib Mesylate_2 / 1259_Talazoparib_3	cell_cyc / other / erk_mapk / other / other / mitosis / mitosis / other / other / other / other / other / pi3k / tor / pi3k / other / other / cell_cyc / chromatin / mitosis / rtk / chromatin / chromatin / chromatin / pi3k / g_integrity / other / mitosis / g_integrity	1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_42142087_A_C
10	NUDT16_1	344_THZ-2-49_3 / 330_XMD13-2_3 / 310_YM201636_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 272_AR-42_2 / 276_CAY10603_3 / 263_FR-180204_3 / 326_GSK690693_3 / 274_Belino_3 Mesylate_2 / 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 / 301_PHA-793887_3 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 299_OSI-027_2 / 1259_Talazoparib_3 / 292_Masitinib_1 / 305_TPCA-1_3 / 298_OSI-930_2 / 290_KIN001-260_3 / 286_KIN001-236_3 / 257_NPK76- II-72-1_3	cell_cyc / other / other / chromatin / mitosis / chromatin / chromatin / erk_mapk / pi3k / chromatin / other / rtk / chromatin / other / mitosis / pi3k / pi3k / cell_cyc / mitosis / rtk / mitosis / tor / g_integrity / rtk / other / rtk / other / other / mitosis	1_26457907_T_G
11	BDKRB1_1	310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 136_Mitomy_ 715_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 303_PIK-93_3 / 301_PHA-793887_3 / 346_THZ-2-102-1_3 / 1008_Methotrexate_1 / 304_SB52334_3 / 253_XMD14-99_3 / 257_NPK76-IIG 299_OSI-027_2 / 286_KIN001-236_3	other / mitosis / erk_mapk / other / pi3k / g_integrity / cell_cyc / other / DNArep / other / other / pi3k / rtk / jnk_p38 / mitosis / other / pi3k / cell_cyc / cell_cyc / DNArep / rtk / rtk / mitosis / abl / pi3k / rtk / tor / other	22_22643666_C_G
12	ACVR1B_1	294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 310_YM201636_3 / 290_KIN001-260_3 / 303_PIK-93_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 225_Genentech Cpd 10_3 / 272_AR-42_2 / 228_AKT_inhibitor_VIII_3 / 274_Belinostat_1 / 253_XMD14-99_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 / 223_ZSTK474_2 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 281_Alectinib_2 / 273_CUDC-101_2 / 326_GSK690693_3 / 330_XMD13-2_3 / 291_KIN001-266_3 / 152180	mitosis / other / rtk / other / other / pi3k / chromatin / chromatin / mitosis / chromatin / pi3k / chromatin / rtk / mitosis / pi3k / igfr / mitosis / pi3k / tor / other / rtk / chromatin / pi3k / other / other / g_integrity / erk_mapk	1_26457907_T_G
13	FUCA2_5	310_YM201636_3 / 344_THZ-2-49_3 / 245_UNC0638_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 273_CUDC-101_2 / 288_WHI-P97_3 / 330_XMD13-2_3 -7-24-1_3 / 253_XMD14-99_3 / 304_SB52334_3 / 326_GSK690693_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 271_VNLG / 124_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 306e	other / cell_cyc / chromatin / erk_mapk / mitosis / pi3k / chromatin / other / other / other / other / pi3k / chromatin / other / rtk / rtk / pi3k / chromatin / mitosis / chromatin / cell_cyc / mitosis / rtk / chromatin / chromatin / other	1_26457907_T_G / 5_141432375_A_C / 22_18847351_G_C / 1_219210601_T_G / 22_22643666_C_G
14	ZNF862_2	226_GSK1070916_2 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 222_BX-912_3-1-2_93_301_93 265_Tubastatin A_3 / 260_NG-25_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 328_SNX-2112_3 / 299_OSI-027_2 / 287_KIN001-244_3 / 330_XMD13-2_3 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2	mitosis / cell_cyc / other / other / mitosis / other / pi3k / mitosis / pi3k / mitosis / cell_cyc / chromatin / other / other / pi3k / other / other / tor / pi3k / other / pi3k / pi3k / other / pi3k / erk_mapk / mitosis	1_26457907_T_G / 22_22759034_G_A
15	JAKMIP2_1	310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 298_OSI-930_2 / 252_WZ3105_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 306_Fedratinib_2 / 253_XMD14-99_3 / 221_TAK- 715_2 / 305_TPCA-1_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 301_PHA-793887_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 / 290_KIN001-260_3 / 292_MasiLinb_1 185	other / pi3k / other / erk_mapk / mitosis / cell_cyc / other / rtk / other / g_integrity / mitosis / pi3k / other / rtk / jnk_p38 / other / other / rtk / cell_cyc / pi3k / erk_mapk / mitosis / other / rtk / igfr	22_21127217_C_G
16	RHBDD2_2	326_GSK690693_3 / 283_Omipalisib_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 304_SB52334_3 / 185_Linsitinib_2 / 310_YM201636_3 / 223_ZSTK474_2 / 299__JI-027- 1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 302_PI-103_3 / 344_THZ-2-49_3 / 219_AT-7519_2 / 245_UNC0638_3 / 330_XMD13-2_3 / 225_Genentech Cpd 10_3 / 289	pi3k / pi3k / other / mitosis / pi3k / rtk / igfr / other / pi3k / tor / other / other / cell_cyc / other / mitosis / mitosis / pi3k / cell_cyc / cell_cyc / chromatin / other / mitosis / other	1_26457907_T_G / 22_30937565_T_G
17	NELL2_2	281_Alectinib_2 / 310_YM201636_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 276_CAY10603_3 / 273_CUDC-101_2 / 260_3_ / 346_THZ-2-102-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 272_AR-42_2 / 222_BX-912_3 / 256_JW-7-24-1_3 / 298_OSI-930_2 / 223_ZSTK474_2	rtk / other / cell_cyc / mitosis / mitosis / other / pi3k / chromatin / chromatin / mitosis / chromatin / other / chromatin / erk_mapk / cell_cyc / pi3k / other / other / chromatin / pi3k / other / rtk / pi3k	1_26457907_T_G / 5_141432375_A_C
18	LIPI_3_23	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 298_OSI-930_2 / 256_TP-24 288_WHI-P97_3 / 290_KIN001-260_3 / 326_GSK690693_3 / 341_Selisistat_3 / 1259_Talazoparib_3 / 271_VNLG / 124_3 / 292_Masitinib_1 / 303_PIK-93_3 / 221_TAK-715_2 / 301_HA_	erk_mapk / other / cell_cyc / mitosis / other / rtk / pi3k / other / rtk / other / other / other / other / other / pi3k / other / g_integrity / chromatin / rtk / pi3k / jnk_p38 / cell_cyc / rtk	1_26457907_T_G / 5_141432375_A_C / 15_25177023_G_C
19	RUNX1_1	263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 211_TL-2-105_3 / 253_XMD14-99_3 / 305_TPCA-1_3 / 225_Genentech Cpd 10_3 715_2 / 223_ZSTK474_2 / 330_XMD13-2_3 / 303_PIK-93_3 / 326_GSK690693_3 / 136_Mitomycin-C_1 / 304_SB52334_3 / 301_PHA-793887_3 / 254_Quizartinib_2 / 252_WZ3105_3 / 346TH	erk_mapk / other / pi3k / mitosis / other / erk_mapk / rtk / other / mitosis / cell_cyc / mitosis / pi3k / jnk_p38 / pi3k / other / pi3k / pi3k / DNArep / rtk / cell_cyc / rtk / other / cell_cyc	1_26457907_T_G
20	UGT3A2_1	310_YM201636_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3_3 / 3_3_2 / 399 152_CP466722_3 / 283_Omipalisib_2 / 271_VNLG / 124_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 / 326_GSK690693_3 / 331_QL-X-138_3 / 223_ZSTK474_2 / 253_290	other / erk_mapk / other / other / rtk / mitosis / cell_cyc / pi3k / pi3k / tor / other / other / g_integrity / pi3k / chromatin / other / g_integrity / other / pi3k / other / pi3k / rtk / other	1_26457907_T_G
21	SLAIN1_2	310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 281_Alectinib_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_2_3_Z2_Z 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 222_BX-912_3	other / pi3k / erk_mapk / rtk / mitosis / other / mitosis / other / pi3k / cell_cyc / pi3k / other / pi3k / tor / other / pi3k / mitosis / cell_cyc / g_integrity / pi3k	1_26457907_T_G / 22_21127217_C_G
22	TRPM4_3	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 283_Omipalisib_2 / 330_XMD13-2_3 / 1495_Olaparib_1 / 305_TPCA-1_3 / 304_SB52334_3 / 226_GSK1070916_2 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 346_THZ-2-102-1_3 / 253_XMD14-99_3 / 271_VNLG / 124_3	erk_mapk / other / cell_cyc / other / mitosis / other / g_integrity / pi3k / pi3k / pi3k / other / g_integrity / other / rtk / mitosis / mitosis / pi3k / cell_cyc / rtk / chromatin	1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G
23	SLC24A3_1	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 271_VNLG / 124_3 / 286_KIN001-236_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 205_Avagacestat_2 / 281_Alectinib_2 / 326_GSK690693_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 298_OSI- 930_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 1495_Olaparib_1	erk_mapk / other / cell_cyc / chromatin / other / g_integrity / pi3k / other / rtk / other / rtk / pi3k / other / rtk / rtk / mitosis / pi3k / other / other / g_integrity	22_22643666_C_G
24	NCKAP1L_1	263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 256_JW-7-24-1_3 / 326_GSK690693_3 / 299_OSI-027_2 / 223_ZSTK474_2 / 304_SB52334_3_3 344_THZ-2-49_3 / 152_CP466722_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 271_VNLG / 124_3 / 226_GSK1070916_2	erk_mapk / other / pi3k / other / other / pi3k / tor / pi3k / rtk / other / pi3k / g_integrity / mitosis / other / cell_cyc / g_integrity / pi3k / other / chromatin / mitosis	1_26457907_T_G
25	RAB32_3	294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 326_GSK690693_3 / 252_WZ3105_3 / 222_BX-912_3 / 226_GSK1070916_2 / 290_KIN001-260_3 / 305_TPCA-1_3 7-24-1_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 254_Quizartinib_2 / 283_Omipalisib_2	mitosis / pi3k / other / pi3k / other / pi3k / mitosis / other / other / other / mitosis / erk_mapk / rtk / other / pi3k / cell_cyc / g_integrity / rtk / pi3k	1_26457907_T_G / 15_92992967_C_T / 5_141477711_A_G
26	E2F5_1	263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 326_GSK690693_3 / 305_TPCA-1_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 290_KIN001-260_3 / 211_TL-2-105_3 / 304_SB52334_3 / 252_WZ3105_3 / 303_PIK-93_3 / 221_TAK- 715_2 / 265_Tubastatin A_3 / 223_ZSTK474_2 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3	erk_mapk / other / mitosis / pi3k / rtk / pi3k / other / mitosis / pi3k / other / erk_mapk / rtk / other / pi3k / jnk_p38 / chromatin / pi3k / mitosis / other	8_22080213_T_C
27	RBM11_5	310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 226_GSK1070916__3 AZ 93_3 / 223_ZSTK474_2 / 271_VNLG / 124_3 / 253_XMD14-99_3 / 283_Omipalisib_2	other / erk_mapk / cell_cyc / other / other / pi3k / mitosis / rtk / mitosis / pi3k / other / g_integrity / other / pi3k / pi3k / chromatin / rtk / pi3k	1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 8_109483107_T_G / 22_18847351_G_C
28	JHDM1D_1	310_YM201636_3 / 279_BIX02189_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 290_KIN001-260_3 / 288_WHI-P97_3 / 299_OSI- 027_2 / 257_NPK76-II-72-1_3 / 253_XMD14-99_3	other / other / other / other / pi3k / pi3k / erk_mapk / other / rtk / other / pi3k / pi3k / other / other / tor / mitosis / rtk	22_21127217_C_G
29	SDC1_2	310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 211_TL-2-105_3 / 283_Omi305_TP 290_KIN001-260_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 281_Alectinib_2 / 254_Quizartinib_2 / 263_FR-180204_3	other / other / mitosis / mitosis / pi3k / pi3k / cell_cyc / erk_mapk / pi3k / other / other / other / pi3k / cell_cyc / rtk / rtk / erk_mapk	1_26457907_T_G / 3_52520584_A_C
30	ENPP3_2	344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_394_ 1_3 / 326_GSK690693_3 / 281_Alectinib_2 / 331_QL-X-138_3 / 305_TPCA-1_3	cell_cyc / other / other / erk_mapk / other / pi3k / pi3k / pi3k / cell_cyc / mitosis / other / mitosis / pi3k / rtk / other / other	1_26457907_T_G / 22_22643666_C_G
31	RBM33_1	294_MPS-1-IN-1_3 / 263_FR-180204_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 326_GSK690693_3 / 283_Oi 299_OSI-027_2 / 331_QL-X-138_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 330_XMD13-2_3	mitosis / erk_mapk / other / other / other / cell_cyc / cell_cyc / other / pi3k / pi3k / mitosis / tor / other / chromatin / other / other	1_26457907_T_G
32	MYOM2_1	263_FR-180204_3 / 310_YM201636_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 208_Ispinesib_3_ -930_2 / 306_Fedratinib_2 / 344_THZ-2-49_3	erk_mapk / other / mitosis / mitosis / other / other / pi3k / other / mitosis / pi3k / mitosis / jnk_p38 / other / rtk / other / cell_cyc	1_26457907_T_G
33	ADRB1_1	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 185_Linsitinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 286_KIN001- 236_3 / 221_TAK-715_2	erk_mapk / other / cell_cyc / mitosis / other / pi3k / rtk / pi3k / other / other / pi3k / igfr / mitosis / other / other / jnk_p38	1_26457907_T_G
34	FAM19A5_1	310_YM201636_3 / 253_XMD14-99_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 211_TL-2-105_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 254_Quizartinib_2 / 305_TPCA-1_3_3_93_3_3_3_P_P_P_1_3_P_P 24-1_3 / 281_Alectinib_2 / 224_AS605240_3	other / rtk / erk_mapk / pi3k / erk_mapk / pi3k / pi3k / rtk / other / mitosis / pi3k / other / rtk / other / rtk / pi3k	22_22643666_C_G
35	CDK6_2	228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 254_Quizartinib_2 / 211_TL-2-105_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 223_ZSTK474_2 / 224_AS605240_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 282_Pelitinib_2 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 221_TAK- 715_2	pi3k / rtk / rtk / erk_mapk / pi3k / mitosis / other / pi3k / pi3k / other / erk_mapk / other / egfr / mitosis / rtk / jnk_p38	6_31662176_A_G / 6_31662464_C_T
36	C1orf54_1	221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 / 341_Selisistat_3 / 298_OSI-930_2 / 330_XMD13-2_3 / 286_KIN001-236_3 / 346_THZ-2-102-1_3 / NG 92_3 / 345_KIN001-270_3 / 292_Masitinib_1	jnk_p38 / pi3k / erk_mapk / other / other / rtk / other / other / cell_cyc / other / DNArep / mitosis / other / rtk / cell_cyc / rtk	8_22080213_T_C
37	HOOK1_1	263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 271_VNLG / 124_3 / 330_XMD13-2_3 / 304_S_252 -1_3 / 1495_Olaparib_1	erk_mapk / cell_cyc / other / other / mitosis / g_integrity / chromatin / other / rtk / pi3k / pi3k / mitosis / tor / mitosis / other / g_integrity	1_26457907_T_G
38	EVI2A_1	228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 179_5-Fluorouracil_1 / 326_GSK690693_3 / 253_XMD14-99_3 / 330_XMD13-2_3 / 223_ZSTK474_2 / 238_Idelalisib_1 / 136_Mitomycin-C_1 / 305_TPCA-1_3	pi3k / mitosis / other / mitosis / erk_mapk / jnk_p38 / pi3k / DNArep / pi3k / rtk / other / pi3k / pi3k / DNArep / other	1_26457907_T_G
39	KDSR_1	310_YM201636_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 287_KIN001-244_3 / 344_3 / 4344 328_SNX-2112_3 / 304_SB52334_3 / 330_XMD13-2_3 / 271_VNLG / 124_3 / 1259_Talazoparib_3	other / pi3k / cell_cyc / erk_mapk / other / mitosis / other / mitosis / pi3k / cell_cyc / other / rtk / other / chromatin / g_integrity	22_21127217_C_G
40	TRIM69_1	310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 136_Mitomycin-C_1 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 328_SN_112_3 027_2 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 1018_Veliparib_2	other / mitosis / other / DNArep / DNArep / other / other / pi3k / pi3k / other / cell_cyc / tor / mitosis / erk_mapk / g_integrity	22_21127217_C_G
41	FAM69A_1	310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 1017_Olaparib_2 / 303_PIK-93_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 / 290_290_290 346_THZ-2-102-1_3 / 208_Ispinesib Mesylate_2	other / mitosis / other / erk_mapk / g_integrity / pi3k / pi3k / mitosis / rtk / cell_cyc / rtk / other / mitosis / cell_cyc / mitosis	4_105679196_A_C
42	MCF2_1	310_YM201636_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 276_CAY10603_3 / 263_FR-180204_3 / 221_TAK-715_2 / 1259_Talazrib 99_3 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3	other / cell_cyc / other / mitosis / mitosis / other / chromatin / erk_mapk / jnk_p38 / g_integrity / mitosis / chromatin / rtk / chromatin / pi3k	15_42142087_A_C
43	DNMT3A_1	263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 286_KIN001-236_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 290_K__3_Cana / 260_K 1091_BMS-536924_3	erk_mapk / cell_cyc / other / other / mitosis / g_integrity / pi3k / other / other / DNArep / pi3k / other / rtk / other / igfr	1_26457907_T_G
44	RAP1GAP_1	226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 326_GSK690693_3 / 260 288_WHI-P97_3 / 299_OSI-027_2	mitosis / other / erk_mapk / mitosis / other / cell_cyc / mitosis / pi3k / pi3k / other / other / other / other / tor	1_26457907_T_G
45	GCNT1_2	221_TAK-715_2 / 330_XMD13-2_3 / 292_Masitinib_1 / 310_YM201636_3 / 208_Ispinesib Mesylate_2 / 301_PHA-793887_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 253_XT_inhibitor_VIII_3 / 253_XMD_	jnk_p38 / other / rtk / other / mitosis / cell_cyc / g_integrity / pi3k / rtk / other / rtk / erk_mapk / cell_cyc / mitosis	22_22643666_C_G / 1_26457907_T_G
46	ACVR2B_1	228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 298_OSI-930_2 / 226_GSK1070916_2 / 330_XMD13-2_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 290	pi3k / jnk_p38 / rtk / mitosis / other / pi3k / mitosis / other / rtk / pi3k / erk_mapk / mitosis / mitosis / rtk	20_10639627_G_A
47	FLII_1	294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 208_Ispinesib Me3late 236_3 / 252_WZ3105_3 / 305_TPCA-1_3	mitosis / other / cell_cyc / other / mitosis / erk_mapk / mitosis / chromatin / mitosis / other / other / other / other / other	3_52520584_A_C
48	TGS1_1	326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 330_XMD13-2_3_ _ 24-1_3 / 279_BIX02189_3	pi3k / erk_mapk / other / mitosis / mitosis / pi3k / other / rtk / other / mitosis / rtk / pi3k / other / other	12_52771095_C_G
49	XG_2	310_YM201636_3 / 288_WHI-P97_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 304_SB52334_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 303_P_I3_93_93 027_2	other / other / other / erk_mapk / mitosis / other / rtk / cell_cyc / other / pi3k / pi3k / other / tor	22_21127217_C_G / 1_26457907_T_G
50	PCDH17_2	344_THZ-2-49_3 / 281_Alectinib_2 / 252_WZ3105_3 / 330_XMD13-2_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 256_JW-7-24-1_3 / 326_G_S3 _	cell_cyc / rtk / other / other / other / erk_mapk / mitosis / pi3k / other / pi3k / mitosis / pi3k / pi3k	1_26457907_T_G / 5_141432375_A_C
51	FCGRT_4	310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3_3 II-72-1_3	other / erk_mapk / cell_cyc / mitosis / other / g_integrity / pi3k / other / pi3k / other / pi3k / cell_cyc / mitosis	1_26457907_T_G / 22_22643666_C_G / 5_141432375_A_C / 22_21127217_C_G
52	PPAPDC2_5	263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_V__300_3_3	erk_mapk / other / g_integrity / mitosis / cell_cyc / other / other / other / pi3k / DNArep / other / pi3k / other	1_26457907_T_G / 15_42142087_A_C / 19_3179506_A_C / 8_22080213_T_C / 22_22643666_C_G
53	OTUD1_1	310_YM201636_3 / 252_WZ3105_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 254_Quizartinib_2 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 270_N_P_C3 / 290	other / other / other / erk_mapk / other / rtk / rtk / pi3k / other / other / mitosis / egfr / chromatin	3_128992964_T_G
54	IRS2_2	344_THZ-2-49_3 / 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 305 -3 102-1_3	cell_cyc / other / erk_mapk / pi3k / other / mitosis / pi3k / mitosis / other / other / rtk / cell_cyc	1_26457907_T_G / 22_22643666_C_G
55	AKAP7_1	263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 290_KIN001-260_3 / 305_TPCA-1_2_I_2_I_2_I2_29	erk_mapk / other / mitosis / cell_cyc / other / pi3k / other / other / other / rtk / mitosis / tor	1_26457907_T_G
56	PCMTD2_1	304_SB52334_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 252_WZ3105_3	rtk / mitosis / other / pi3k / erk_mapk / other / pi3k / DNArep / other / g_integrity / pi3k / other	1_26457907_T_G
57	ANXA11_1	305_TPCA-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 279_BIX02189_3 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 253_X_	other / other / erk_mapk / mitosis / other / mitosis / pi3k / pi3k / rtk / rtk / other / other	1_26457907_T_G
58	CYP4F22_1	310_YM201636_3 / 330_XMD13-2_3 / 211_TL-2-105_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 294_MPS-1-_3_3_3_39_3 / 3_39	other / other / erk_mapk / pi3k / erk_mapk / other / mitosis / mitosis / mitosis / cell_cyc / pi3k / other	22_21127217_C_G
59	FAH_1	344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 252_WZ3105_3_93_93_93K 330_XMD13-2_3	cell_cyc / mitosis / other / erk_mapk / other / other / mitosis / other / other / pi3k / other / other	22_22643666_C_G
60	PRSS35_1	263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3_Travel 100_	erk_mapk / other / pi3k / other / other / other / mitosis / cell_cyc / other / other / DNArep / g_integrity	1_26457907_T_G
61	ARID2_1	263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_II-305	erk_mapk / other / mitosis / other / mitosis / cell_cyc / pi3k / pi3k / other / other / mitosis	1_26457907_T_G
62	GBE1_2	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 304_S3	erk_mapk / mitosis / other / other / pi3k / pi3k / mitosis / DNArep / other / rtk / pi3k	1_26457907_T_G / 22_22643666_C_G
63	FEZF1_2	310_YM201636_3 / 263_FR-180204_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 228_VT_information	other / erk_mapk / other / g_integrity / pi3k / other / mitosis / cell_cyc / mitosis / pi3k / other	1_26457907_T_G / 22_22643666_C_G
64	ACACB_2	228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 1008_Methotrexate_1 / 252_WZ3105_3 / 326_GSK690693_3 / 222_BX-912_3_303	pi3k / other / mitosis / pi3k / erk_mapk / DNArep / other / pi3k / pi3k / pi3k / rtk	1_26457907_T_G / 22_18847351_G_C
65	CUX2_1	330_XMD13-2_3 / 310_YM201636_3 / 299_OSI-027_2 / 304_SB52334_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 326_GSK690693_3 / 228_AKT_inhibitor	other / other / tor / rtk / other / erk_mapk / pi3k / other / pi3k / pi3k / mitosis	22_21127217_C_G
66	H2AFY2_1	1259_Talazoparib_3 / 263_FR-180204_3 / 310_YM201636_3 / 1495_Olaparib_1 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 271_VNLG / 124_3 / 344_THZ-2-49_3 / 221_TAK-715_2 / 226_G941070916-1-	g_integrity / erk_mapk / other / g_integrity / DNArep / other / chromatin / cell_cyc / jnk_p38 / mitosis / mitosis	22_22643666_C_G
67	SCNN1G_1	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 288_WHI-P97_3_39_94_3_94_3_94_	erk_mapk / other / cell_cyc / other / g_integrity / pi3k / other / jnk_p38 / other / mitosis / pi3k	1_26457907_T_G
68	MICAL2_1	228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 310_YM201636_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 254	pi3k / pi3k / other / pi3k / erk_mapk / rtk / mitosis / jnk_p38 / other / erk_mapk / rtk	6_151015603_C_G
69	SWT1_2	310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 253_XMD14-99_3 / 211_TL-2-105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 105G	other / pi3k / cell_cyc / rtk / erk_mapk / erk_mapk / other / jnk_p38 / pi3k / other / mitosis	1_26457907_T_G / 8_109483107_T_G
70	PDE6B_1	286_KIN001-236_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 206_Ruxolitinib_1 / 1012_Vorinostat13 / 330	other / erk_mapk / g_integrity / other / rtk / pi3k / mitosis / other / chromatin / other / other	15_42142087_A_C
71	FUT11_4	310_YM201636_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 286_KIN001-236_3 / 291_KIN001-266_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3-1-94-1	other / other / other / other / other / cell_cyc / pi3k / rtk / other / mitosis	1_26457907_T_G / 22_24252424_G_C / 22_21127217_C_G / 22_22643666_C_G
72	CRMP1_2	299_OSI-027_2 / 310_YM201636_3 / 256_JW-7-24-1_3 / 305_TPCA-1_3 / 274_Belinostat_1 / 263_FR-180204_3 / 276_CAY10603_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 272_AR-42_2	tor / other / other / other / chromatin / erk_mapk / chromatin / other / mitosis / chromatin	22_21127217_C_G / 1_26457907_T_G
73	ATP2B3_2	281_Alectinib_2 / 310_YM201636_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 305_TPCA-1_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 290_K001	rtk / other / other / pi3k / mitosis / mitosis / other / erk_mapk / cell_cyc / other	1_26457907_T_G / 17_7604041_A_C
74	KLHL23_2	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 326_SK3	erk_mapk / mitosis / pi3k / other / rtk / rtk / rtk / other / igfr / pi3k	1_26457907_T_G / 5_141432375_A_C
75	PNMAL1_1	310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 283_Omipalisib_2 / 261_TL-1-85_3 / 228_AK	other / mitosis / mitosis / pi3k / other / cell_cyc / cell_cyc / pi3k / other / pi3k	1_26457907_T_G
76	DPP9_1	263_FR-180204_3 / 1008_Methotrexate_1 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 326_G690	erk_mapk / DNArep / igfr / pi3k / mitosis / mitosis / other / other / rtk / pi3k	22_21127217_C_G
77	GPC2_1	228_AKT_inhibitor_VIII_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 283_Omipalisib_2 / 226_GSK10709163 / 252_3	pi3k / igfr / mitosis / pi3k / erk_mapk / other / other / pi3k / mitosis / other	5_141432375_A_C
78	RBM27_1	330_XMD13-2_3 / 265_Tubastatin A_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 271_VNLG / 124_3 / 326_GSK690693_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-204	other / chromatin / cell_cyc / mitosis / chromatin / pi3k / chromatin / mitosis / other / erk_mapk	19_48617887_T_G
79	HOXD13_1	344_THZ-2-49_3 / 263_FR-180204_3 / 298_OSI-930_2 / 1248_Daporinad_3 / 1259_Talazoparib_3 / 1091_BMS-536924_3 / 310_YM201636_3 / 136_Mitomycin-C_1 / 326_GSK690693_3 / 294_MPS-1-IN	cell_cyc / erk_mapk / rtk / metabol / g_integrity / igfr / other / DNArep / pi3k / mitosis	1_26457907_T_G
80	TFCP2_1	226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 / 330_MD	mitosis / mitosis / erk_mapk / pi3k / rtk / pi3k / other / other / rtk / other	19_55796171_G_T
81	MLC1_2	310_YM201636_3 / 1011_Navitoclax_2 / 344_THZ-2-49_3 / 263_FR-180204_3 / 303_PIK-93_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 346_THZ-2-102-1_3 / 252_WZ3105_3	other / apop / cell_cyc / erk_mapk / pi3k / other / pi3k / cell_cyc / other	1_26457907_T_G / 7_72941936_T_C
82	NUDT10_1	330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 281_Alectinib_2	other / pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk	1_26457907_T_G
83	ABHD6_5	344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_2 / 265_Tubastatin A_3	cell_cyc / other / other / pi3k / mitosis / other / mitosis / chromatin / chromatin	12_52771095_C_G / 1_26457907_T_G / 22_18847351_G_C / 5_141432375_A_C / 22_21127217_C_G
84	NDST4_2	310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 283_Omipalisib_2	other / other / erk_mapk / other / cell_cyc / pi3k / mitosis / other / pi3k	1_26457907_T_G / 1_219210601_T_G
85	POU3F2_5	344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 263_FR-180204_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 281_Alectinib_2	cell_cyc / other / other / mitosis / other / erk_mapk / cell_cyc / mitosis / rtk	1_26457907_T_G / 5_141432375_A_C / 1_219210601_T_G / 1_205381583_C_G / 3_52520584_A_C
86	RND2_1	263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 221_TAK-715_2 / 253_XMD14-99_3	erk_mapk / pi3k / other / other / rtk / mitosis / other / jnk_p38 / rtk	1_26457907_T_G
87	TEKT2_1	263_FR-180204_3 / 185_Linsitinib_2 / 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 271_VNLG / 124_3	erk_mapk / igfr / cell_cyc / other / other / pi3k / pi3k / mitosis / chromatin	1_26457907_T_G
88	RCOR1_1	263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_	erk_mapk / other / mitosis / cell_cyc / mitosis / pi3k / other / mitosis / other	1_176702776_TGAGAGAGA_T
89	SH3GLB1_1	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1264_SGC0946_3 / 253_XMD14-99_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / mitosis / other / chromatin / rtk / chromatin / other / other / pi3k	22_22643666_C_G
90	ZCCHC5_1	294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 283_Omipalisib_2 / 300_CX-5461_3 / 136_Mitomycin-C_1 / 208_Ispinesib Mesylate_2 / 299_OSI-027_2 / 302_PI-103_3 / 151_QS11_3	mitosis / DNArep / pi3k / other / DNArep / mitosis / tor / pi3k / other	22_22643666_C_G
91	EVI2B_1	310_YM201636_3 / 326_GSK690693_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 344_THZ-2-49_3 / 211_TL-2-105_3	other / pi3k / g_integrity / mitosis / rtk / pi3k / DNArep / cell_cyc / erk_mapk	10_46462341_C_A
92	EPC1_2	310_YM201636_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 303_PIK-93_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 226_GSK1070916_2	other / erk_mapk / g_integrity / other / other / pi3k / mitosis / other / mitosis	19_6744459_C_G / 19_42723940_A_C
93	VAX1_2	310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2	other / erk_mapk / cell_cyc / pi3k / pi3k / other / mitosis / mitosis	1_26457907_T_G / 22_21127217_C_G
94	DLG2_3	263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 304_SB52334_3 / 305_TPCA-1_3	erk_mapk / other / mitosis / pi3k / cell_cyc / igfr / rtk / other	22_21127217_C_G / 22_18847351_G_C / 1_26457907_T_G
95	PPP1R1A_2	310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3	other / erk_mapk / cell_cyc / pi3k / other / other / pi3k / mitosis	1_26457907_T_G / 5_141432375_A_C
96	EFNB1_1	344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 256_JW-7-24-1_3 / 263_FR-180204_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 281_Alectinib_2	cell_cyc / other / other / other / erk_mapk / tor / other / rtk	1_26457907_T_G
97	POU3F1_2	263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / other / g_integrity / mitosis / mitosis / pi3k / other / pi3k	1_26457907_T_G / 22_22643666_C_G
98	JPH1_2	263_FR-180204_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2	erk_mapk / cell_cyc / igfr / mitosis / pi3k / other / other / rtk	1_26457907_T_G / 19_32643405_T_C
99	LGALS3_5	281_Alectinib_2 / 330_XMD13-2_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3	rtk / other / other / cell_cyc / pi3k / other / mitosis / pi3k	1_26457907_T_G / 5_141432375_A_C / 3_51333222_A_C / 7_100760409_A_C / 22_24252424_G_C
100	LRRC4B_1	310_YM201636_3 / 303_PIK-93_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 226_GSK1070916_2	other / pi3k / erk_mapk / pi3k / other / pi3k / cell_cyc / mitosis	22_21127217_C_G
101	ARHGAP19_1	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 305_TPCA-1_3 / 226_GSK1070916_2	erk_mapk / mitosis / other / pi3k / jnk_p38 / other / other / mitosis	22_22643666_C_G
102	MYL9_1	310_YM201636_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3	other / other / cell_cyc / mitosis / mitosis / pi3k / erk_mapk	1_26457907_T_G
103	TMEM170B_1	294_MPS-1-IN-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 326_GSK690693_3	mitosis / other / erk_mapk / pi3k / rtk / other / pi3k	1_26457907_T_G
104	CSAD_1	326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3	pi3k / pi3k / other / mitosis / mitosis / pi3k / other	1_26457907_T_G
105	ASGR1_5	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3	erk_mapk / other / cell_cyc / other / pi3k / mitosis / other	22_22643666_C_G / 1_26457907_T_G / 15_42142087_A_C / 22_21127217_C_G / 5_141432375_A_C
106	KIAA1958_1	310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 223_ZSTK474_2 / 226_GSK1070916_2 / 305_TPCA-1_3	other / erk_mapk / mitosis / pi3k / pi3k / mitosis / other	1_26457907_T_G
107	NPW_2	310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 288_WHI-P97_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3	other / cell_cyc / erk_mapk / mitosis / other / other / pi3k	1_26457907_T_G / 3_52520584_A_C
108	CAP1_1	263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 136_Mitomycin-C_1 / 286_KIN001-236_3	erk_mapk / other / mitosis / other / other / DNArep / other	1_26457907_T_G
109	SIAH3_1	344_THZ-2-49_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 286_KIN001-236_3 / 253_XMD14-99_3	cell_cyc / other / mitosis / other / erk_mapk / other / rtk	1_26457907_T_G
110	PALM3_1	263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 271_VNLG / 124_3 / 304_SB52334_3	erk_mapk / pi3k / mitosis / pi3k / pi3k / chromatin / rtk	22_22643666_C_G
111	STMN3_1	303_PIK-93_3 / 260_NG-25_3 / 300_CX-5461_3 / 287_KIN001-244_3 / 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3	pi3k / other / other / pi3k / other / other / mitosis	6_110102054_T_G
112	TMEM81_1	263_FR-180204_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 226_GSK1070916_2	erk_mapk / cell_cyc / pi3k / other / mitosis / other / mitosis	19_7056560_G_T
113	SPATA6L_2	263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 271_VNLG / 124_3 / 286_KIN001-236_3 / 304_SB52334_3 / 1008_Methotrexate_1	erk_mapk / g_integrity / other / chromatin / other / rtk / DNArep	8_1678462_A_C / 1_26457907_T_G
114	CSRP2BP_5	228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3	pi3k / other / cell_cyc / mitosis / mitosis / erk_mapk / pi3k	1_26457907_T_G / 17_65225089_T_C / 1_205381583_C_G / 17_7318141_T_G / 16_22266423_T_C
115	MAP2K6_1	228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 310_YM201636_3	pi3k / jnk_p38 / erk_mapk / mitosis / other / rtk / other	6_151015603_C_G
116	HOXB13_1	263_FR-180204_3 / 1008_Methotrexate_1 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 286_KIN001-236_3	erk_mapk / DNArep / mitosis / other / pi3k / g_integrity / other	1_26457907_T_G
117	RBM12B_1	326_GSK690693_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 253_XMD14-99_3 / 305_TPCA-1_3	pi3k / mitosis / rtk / erk_mapk / other / rtk / other	8_131984112_C_T
118	ADRB3_1	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3	erk_mapk / other / cell_cyc / pi3k / mitosis / other	1_26457907_T_G
119	LUC7L_5	263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 326_GSK690693_3	erk_mapk / pi3k / other / mitosis / rtk / pi3k	1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_50544697_C_A / 5_141432375_A_C
120	ITM2A_1	344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 256_JW-7-24-1_3	cell_cyc / erk_mapk / other / other / other / other	1_26457907_T_G
121	ICAM4_1	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 298_OSI-930_2 / 344_THZ-2-49_3	erk_mapk / mitosis / other / pi3k / rtk / cell_cyc	1_26457907_T_G
122	HMCN1_1	310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 344_THZ-2-49_3	other / other / erk_mapk / pi3k / pi3k / cell_cyc	1_26457907_T_G
123	ZNF397_4	310_YM201636_3 / 276_CAY10603_3 / 245_UNC0638_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 303_PIK-93_3	other / chromatin / chromatin / mitosis / erk_mapk / pi3k	22_22643666_C_G / 22_21127217_C_G / 15_56693096_A_C / 1_26457907_T_G
124	DRAP1_1	305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 290_KIN001-260_3	other / mitosis / erk_mapk / other / pi3k / other	1_26457907_T_G
125	DTX3L_1	305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 290_KIN001-260_3	other / other / mitosis / erk_mapk / mitosis / other	1_26457907_T_G
126	NUDT11_5	310_YM201636_3 / 281_Alectinib_2 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3	other / rtk / cell_cyc / mitosis / other / mitosis	1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 1_219210601_T_G / 22_18847351_G_C
127	ADAM19_3	265_Tubastatin A_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 / 271_VNLG / 124_3	chromatin / erk_mapk / mitosis / other / other / chromatin	22_21127217_C_G / 22_21283300_G_C / 14_68882917_A_G
128	HS3ST4_2	263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 344_THZ-2-49_3	erk_mapk / other / pi3k / pi3k / other / cell_cyc	1_26457907_T_G / 12_52771095_C_G
129	CRIPAK_4	346_THZ-2-102-1_3 / 261_TL-1-85_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3	cell_cyc / other / pi3k / pi3k / mitosis / other	9_137101572_A_C / 4_48557504_A_G / 6_160247199_T_G / 7_44697564_T_G
130	OLFM3_1	263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 298_OSI-930_2	erk_mapk / cell_cyc / other / other / other / rtk	22_22643666_C_G
131	LMO2_4	344_THZ-2-49_3 / 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 1259_Talazoparib_3 / 252_WZ3105_3	cell_cyc / erk_mapk / rtk / other / g_integrity / other	5_141432375_A_C / 1_26457907_T_G / 11_1246628_A_C / 15_25177023_G_C
132	SALL2_1	263_FR-180204_3 / 1008_Methotrexate_1 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / DNArep / other / mitosis / g_integrity / pi3k	22_22643666_C_G
133	SLC35F3_1	1495_Olaparib_1 / 330_XMD13-2_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3	g_integrity / other / g_integrity / cell_cyc / other / other	15_42142087_A_C
134	RHOH_1	310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 305_TPCA-1_3	other / erk_mapk / mitosis / other / cell_cyc / other	22_21127217_C_G
135	MED23_1	344_THZ-2-49_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 310_YM201636_3 / 290_KIN001-260_3	cell_cyc / erk_mapk / mitosis / chromatin / other / other	15_42142087_A_C
136	ALS2CR8_2	310_YM201636_3 / 271_VNLG / 124_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 283_Omipalisib_2	other / chromatin / pi3k / g_integrity / pi3k / pi3k	7_5300364_T_G / 11_64118302_A_C
137	PDS5B_1	226_GSK1070916_2 / 281_Alectinib_2 / 253_XMD14-99_3 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 263_FR-180204_3	mitosis / rtk / rtk / pi3k / pi3k / erk_mapk	19_5654163_A_C
138	POU4F1_1	252_WZ3105_3 / 310_YM201636_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 222_BX-912_3 / 330_XMD13-2_3	other / other / mitosis / cell_cyc / pi3k / other	X_149503442_T_G
139	LINGO1_4	263_FR-180204_3 / 310_YM201636_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 294_MPS-1-IN-1_3	erk_mapk / other / other / other / mitosis	22_22643666_C_G / 22_21127217_C_G / 1_26457907_T_G / 11_66624536_A_C
140	EZH2_2	310_YM201636_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3	other / pi3k / mitosis / other / pi3k	1_26457907_T_G / 22_18847351_G_C
141	ZNF786_5	252_WZ3105_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 310_YM201636_3 / 326_GSK690693_3	other / mitosis / pi3k / other / pi3k	1_26457907_T_G / 17_7604041_A_C / 17_78120770_A_C / 22_30937565_T_G / 16_25177910_T_G
142	SLCO5A1_1	263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3	erk_mapk / other / rtk / other / mitosis	1_26457907_T_G
143	DKK2_1	310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 299_OSI-027_2 / 294_MPS-1-IN-1_3	other / cell_cyc / erk_mapk / tor / mitosis	1_26457907_T_G
144	ATP11C_1	344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 273_CUDC-101_2 / 330_XMD13-2_3	cell_cyc / other / other / chromatin / other	1_26457907_T_G
145	KMO_1	310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3	other / erk_mapk / pi3k / other / mitosis	22_21127217_C_G
146	SPOCD1_1	263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 286_KIN001-236_3	erk_mapk / pi3k / other / rtk / other	1_26457907_T_G
147	LMO3_1	228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 223_ZSTK474_2 / 252_WZ3105_3 / 211_TL-2-105_3	pi3k / other / pi3k / other / erk_mapk	1_26457907_T_G
148	SUCLG2_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1242_ (5Z) -7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2	erk_mapk / erk_mapk / other / erk_mapk / erk_mapk	3_160423378_C_T
149	CDC42EP3_1	294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 226_GSK1070916_2	mitosis / pi3k / erk_mapk / other / mitosis	22_21283300_G_C
150	VIM_2	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk	13_99295007_C_T / 13_99314037_A_G
151	KIAA1456_5	263_FR-180204_3 / 288_WHI-P97_3 / 344_THZ-2-49_3 / 310_YM201636_3	erk_mapk / other / cell_cyc / other	1_26457907_T_G / 22_21127217_C_G / 22_22643666_C_G / 3_52520584_A_C / 15_25177023_G_C
152	ATP1A1_1	344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3	cell_cyc / erk_mapk / other / other	1_26457907_T_G
153	EFHD2_3	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3	erk_mapk / mitosis / other / other	1_26457907_T_G / 19_3179506_A_C / 12_48769033_A_C
154	NPY1R_1	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 310_YM201636_3	erk_mapk / mitosis / cell_cyc / other	1_26457907_T_G
155	PTPN13_1	344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3	cell_cyc / other / other / other	1_26457907_T_G
156	SOX11_3	344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3	cell_cyc / erk_mapk / other / pi3k	1_26457907_T_G / 22_21127217_C_G / 5_141432375_A_C
157	RAVER2_1	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 226_GSK1070916_2	erk_mapk / mitosis / other / mitosis	1_26457907_T_G
158	CD44_3	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2	erk_mapk / mitosis / pi3k / mitosis	1_149813302_A_C / 1_26457907_T_G / 6_151015603_C_G
159	WIPI1_1	263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 305_TPCA-1_3	erk_mapk / rtk / other / other	1_26457907_T_G
160	MEIG1_1	310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 281_Alectinib_2	other / pi3k / cell_cyc / rtk	5_141636680_A_C
161	ITGAV_1	1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	3_180647255_T_TA
162	WASF1_2	263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3	erk_mapk / mitosis / other / other	22_22643666_C_G / 22_21127217_C_G
163	SEPT5_1	263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / other / rtk / pi3k	1_26457907_T_G
164	ZNF703_4	263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 304_SB52334_3	erk_mapk / other / cell_cyc / rtk	15_42142087_A_C / 19_3179506_A_C / 22_22643666_C_G / 10_71362188_T_C
165	RCAN1_1	310_YM201636_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3	other / g_integrity / erk_mapk / pi3k	22_22643666_C_G
166	MEIS1_1	310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 330_XMD13-2_3	other / cell_cyc / erk_mapk / other	11_1246619_A_C
167	DOCK9_2	1014_Refametinib_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1	erk_mapk / erk_mapk / erk_mapk / erk_mapk	17_80065379_A_G / 2_87800520_G_A
168	MAP2K1_1	301_PHA-793887_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 330_XMD13-2_3	cell_cyc / g_integrity / erk_mapk / other	22_21127217_C_G
169	BAZ2A_1	263_FR-180204_3 / 298_OSI-930_2 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / rtk / mitosis / pi3k	19_46321845_A_C
170	TMEM70_2	252_WZ3105_3 / 310_YM201636_3 / 303_PIK-93_3 / 301_PHA-793887_3	other / other / pi3k / cell_cyc	1_26457907_T_G / 10_35032524_A_C
171	CSRP3_1	294_MPS-1-IN-1_3 / 328_SNX-2112_3 / 346_THZ-2-102-1_3 / 310_YM201636_3	mitosis / other / cell_cyc / other	2_112722995_T_G
172	MSRB3_1	1372_Trametinib_1 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk / erk_mapk	22_37816755_A_G
173	PTGER2_1	263_FR-180204_3 / 253_XMD14-99_3 / 306_Fedratinib_2 / 1495_Olaparib_1	erk_mapk / rtk / other / g_integrity	20_49068783_G_C
174	ARHGAP44_2	1248_Daporinad_3 / 344_THZ-2-49_3 / 1495_Olaparib_1 / 1259_Talazoparib_3	metabol / cell_cyc / g_integrity / g_integrity	16_55810697_G_T / 16_55813139_C_T
175	TTC7A_2	326_GSK690693_3 / 310_YM201636_3 / 330_XMD13-2_3 / 254_Quizartinib_2	pi3k / other / other / rtk	11_92353347_C_T / 11_92353483_G_A
176	SLC35F1_1	310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3	other / erk_mapk / cell_cyc	1_26457907_T_G
177	KRT25_4	330_XMD13-2_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3	other / other / mitosis	22_21127217_C_G / 1_26457907_T_G / 22_22643666_C_G / 22_24658344_C_G
178	PAX7_1	263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3	erk_mapk / other / pi3k	1_26457907_T_G
179	ENC1_1	263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3	erk_mapk / other / other	1_26457907_T_G
180	ERO1L_3	281_Alectinib_2 / 263_FR-180204_3 / 326_GSK690693_3	rtk / erk_mapk / pi3k	1_26457907_T_G / 5_141432375_A_C / 10_6515090_A_C
181	KANSL2_2	281_Alectinib_2 / 226_GSK1070916_2 / 310_YM201636_3	rtk / mitosis / other	1_26457907_T_G / 12_94248247_C_T
182	RPN1_3	344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3	cell_cyc / other / other	22_22643666_C_G / 5_141432375_A_C / 1_26457907_T_G
183	PTGER3_2	344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3	cell_cyc / other / other	1_26457907_T_G / 1_219210601_T_G
184	CACHD1_2	288_WHI-P97_3 / 263_FR-180204_3 / 344_THZ-2-49_3	other / erk_mapk / cell_cyc	1_26457907_T_G / 2_119366546_A_G
185	VPS37D_2	226_GSK1070916_2 / 305_TPCA-1_3 / 303_PIK-93_3	mitosis / other / pi3k	7_72941936_T_C / 1_26457907_T_G
186	ZDHHC17_1	226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / mitosis / erk_mapk	1_26457907_T_G
187	TMEM9B_2	228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 263_FR-180204_3	pi3k / rtk / erk_mapk	1_26457907_T_G / 11_120298301_A_C
188	HOXD10_1	344_THZ-2-49_3 / 298_OSI-930_2 / 310_YM201636_3	cell_cyc / rtk / other	1_26457907_T_G
189	ITFG2_1	281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3	rtk / pi3k / pi3k	1_26457907_T_G
190	EGFL7_1	263_FR-180204_3 / 271_VNLG / 124_3 / 185_Linsitinib_2	erk_mapk / chromatin / igfr	22_22643666_C_G
191	PPP2R2A_5	310_YM201636_3 / 263_FR-180204_3 / 326_GSK690693_3	other / erk_mapk / pi3k	13_20189082_A_C / 12_52771095_C_G / 1_26457907_T_G / 3_126068075_T_G / 22_21127217_C_G
192	BRF2_2	263_FR-180204_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3	erk_mapk / pi3k / mitosis	22_21283300_G_C / 7_37907554_A_G
193	ATP1B2_1	294_MPS-1-IN-1_3 / 310_YM201636_3 / 290_KIN001-260_3	mitosis / other / other	16_3027533_A_G
194	PTGES3_2	281_Alectinib_2 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3	rtk / chromatin / pi3k	1_26457907_T_G / 1_149813302_A_C
195	NR0B1_2	1259_Talazoparib_3 / 344_THZ-2-49_3 / 310_YM201636_3	g_integrity / cell_cyc / other	1_26457907_T_G / 22_21127217_C_G
196	GALNT10_2	1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	13_99295007_C_T / 13_99314037_A_G
197	TMEM229A_1	263_FR-180204_3 / 1011_Navitoclax_2 / 310_YM201636_3	erk_mapk / apop / other	22_22643666_C_G
198	NCEH1_1	263_FR-180204_3 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3	erk_mapk / igfr / pi3k	6_151015603_C_G
199	C1orf27_1	263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3	erk_mapk / cell_cyc / other	15_25177023_G_C
200	TMEM14C_1	228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3	pi3k / erk_mapk / other	6_31662464_C_T
201	DKK3_1	1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2	erk_mapk / erk_mapk / erk_mapk	11_24729296_G_A
202	LRRC4C_1	263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3	erk_mapk / cell_cyc / other	12_52771095_C_G
203	HOXD9_1	263_FR-180204_3 / 344_THZ-2-49_3 / 136_Mitomycin-C_1	erk_mapk / cell_cyc / DNArep	5_140829601_T_G
204	SLC5A6_2	263_FR-180204_3 / 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3	erk_mapk / jnk_p38 / pi3k	1_184808038_A_C / X_46860063_C_T
205	LYPD1_1	274_Belinostat_1 / 273_CUDC-101_2 / 276_CAY10603_3	chromatin / chromatin / chromatin	1_129285_G_A
206	CIB1_1	263_FR-180204_3 / 226_GSK1070916_2 / 305_TPCA-1_3	erk_mapk / mitosis / other	15_25177023_G_C
207	PDSS1_2	263_FR-180204_3 / 1008_Methotrexate_1 / 288_WHI-P97_3	erk_mapk / DNArep / other	15_89633846_A_C / 22_39376109_T_G
208	SHC2_1	326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3	pi3k / erk_mapk / other	19_54631904_A_C
209	ATP6V0B_1	1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2	erk_mapk / erk_mapk / erk_mapk	1_9850602_T_G
210	SEPSECS_1	341_Selisistat_3 / 286_KIN001-236_3 / 1008_Methotrexate_1	other / other / DNArep	2_28529292_G_T
211	BHLHE22_2	310_YM201636_3 / 263_FR-180204_3	other / erk_mapk	1_26457907_T_G / 22_21127217_C_G
212	FOXC1_1	263_FR-180204_3 / 310_YM201636_3	erk_mapk / other	1_26457907_T_G
213	DMRTA1_1	290_KIN001-260_3 / 286_KIN001-236_3	other / other	7_72949311_A_C
214	CRYBG3_2	263_FR-180204_3 / 294_MPS-1-IN-1_3	erk_mapk / mitosis	22_21127217_C_G / 1_149813302_A_C
215	ANKRD28_1	263_FR-180204_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / pi3k	1_26457907_T_G
216	ZNF467_3	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	17_78120770_A_C / 22_21283300_G_C / 5_157491842_C_T
217	MCU_1	281_Alectinib_2 / 344_THZ-2-49_3	rtk / cell_cyc	1_26457907_T_G
218	ALG6_1	281_Alectinib_2 / 294_MPS-1-IN-1_3	rtk / mitosis	1_26457907_T_G
219	DST_1	263_FR-180204_3 / 185_Linsitinib_2	erk_mapk / igfr	22_22643666_C_G
220	CNOT6_1	263_FR-180204_3 / 294_MPS-1-IN-1_3	erk_mapk / mitosis	22_22643666_C_G
221	SLC25A46_1	283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3	pi3k / pi3k	22_22643666_C_G
222	STRBP_3	263_FR-180204_3 / 1259_Talazoparib_3	erk_mapk / g_integrity	22_22643666_C_G / 16_55810697_G_T / 22_21127217_C_G
223	SLFN11_1	263_FR-180204_3 / 344_THZ-2-49_3	erk_mapk / cell_cyc	15_25177023_G_C
224	IL1R1_1	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	11_66624536_A_C
225	PDE9A_2	271_VNLG / 124_3 / 263_FR-180204_3	chromatin / erk_mapk	19_5654163_A_C / 22_19918884_A_C
226	TXNDC11_1	1011_Navitoclax_2 / 344_THZ-2-49_3	apop / cell_cyc	19_624780_A_G
227	NRP1_2	1526_Refametinib_3 / 1014_Refametinib_2	erk_mapk / erk_mapk	3_180647255_T_TA / 15_68718780_C_T
228	QSER1_1	344_THZ-2-49_3 / 310_YM201636_3	cell_cyc / other	6_31464043_C_T
229	TNIP1_1	1526_Refametinib_3 / 154_CHIR-99021_3	erk_mapk / wnt	3_180647255_T_TA
230	LIMS1_1	1372_Trametinib_1 / 1526_Refametinib_3	erk_mapk / erk_mapk	8_138630731_T_C
231	PNISR_1	265_Tubastatin A_3 / 292_Masitinib_1	chromatin / rtk	15_42142087_A_C
232	MOAP1_1	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	20_53576113_T_G
233	KAT2B_3	228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3	pi3k / mitosis	19_17618978_T_G / 19_17618863_T_TG / 22_22643666_C_G
234	NBAS_2	292_Masitinib_1 / 286_KIN001-236_3	rtk / other	1_182843301_T_G / 2_112783793_A_C
235	RPAP3_1	281_Alectinib_2 / 310_YM201636_3	rtk / other	16_3027533_A_G
236	PCDH8_1	263_FR-180204_3 / 310_YM201636_3	erk_mapk / other	12_52771095_C_G
237	NRTN_1	185_Linsitinib_2 / 294_MPS-1-IN-1_3	igfr / mitosis	1_149813302_A_C
238	NFE2L3_3	1242_ (5Z) -7-Oxozeaenol_3 / 1014_Refametinib_2	other / erk_mapk	22_32394994_C_G / X_119791251_A_C / 5_113434330_T_G
239	AXL_2	1526_Refametinib_3 / 1372_Trametinib_1	erk_mapk / erk_mapk	4_42616004_T_TA / 4_42616121_A_G
240	FAM84B_1	263_FR-180204_3 / 344_THZ-2-49_3	erk_mapk / cell_cyc	13_24951498_G_C
241	SERPING1_2	263_FR-180204_3 / 228_AKT_inhibitor_VIII_3	erk_mapk / pi3k	19_4930892_T_G / 1_151048750_A_C
242	MAN2A2_1	294_MPS-1-IN-1_3 / 263_FR-180204_3	mitosis / erk_mapk	18_112338_G_A
243	PPP1R1B_2	1015_CI-1040_2 / 1062_Selumetinib_2	erk_mapk / erk_mapk	6_53899709_T_G / 7_99012221_A_C
244	LIM2_1	211_TL-2-105_3 / 345_KIN001-270_3	erk_mapk / cell_cyc	1_193249713_C_G
245	ENC1_1	1526_Refametinib_3 / 1372_Trametinib_1	erk_mapk / erk_mapk	15_69422319_A_C
246	TXNDC15_1	281_Alectinib_2 / 228_AKT_inhibitor_VIII_3	rtk / pi3k	12_121016539_T_A
247	CTGF_1	1372_Trametinib_1 / 1498_Selumetinib_2	erk_mapk / erk_mapk	10_99533046_A_G
248	EGFLAM_2	281_Alectinib_2 / 252_WZ3105_3	rtk / other	2_217818534_A_G / 2_217817751_A_G
249	ARHGAP10_2	263_FR-180204_3	erk_mapk	22_22643666_C_G / 1_26457907_T_G
250	EBF3_1	344_THZ-2-49_3	cell_cyc	1_26457907_T_G
251	PLAGL2_1	263_FR-180204_3	erk_mapk	1_26457907_T_G
252	XKR4_3	263_FR-180204_3	erk_mapk	1_26457907_T_G / 12_52771095_C_G / 22_21127217_C_G
253	HR_1	288_WHI-P97_3	other	1_26457907_T_G
254	GLB1L2_1	263_FR-180204_3	erk_mapk	22_22643666_C_G
255	GOLIM4_1	263_FR-180204_3	erk_mapk	22_22643666_C_G
256	TMEM127_1	263_FR-180204_3	erk_mapk	22_22643666_C_G
257	USP21_1	263_FR-180204_3	erk_mapk	22_22643666_C_G
258	FAIM_5	344_THZ-2-49_3	cell_cyc	5_141432375_A_C / 1_26457907_T_G / 17_49252681_A_C / 10_122983276_G_A / 15_84654249_A_C
259	COX19_2	326_GSK690693_3	pi3k	22_24658344_C_G / 1_26457907_T_G
260	LRP10_3	344_THZ-2-49_3	cell_cyc	1_26457907_T_G / 12_52771095_C_G / 22_22643666_C_G
261	ASPH_1	1526_Refametinib_3	erk_mapk	3_180647255_T_TA
262	CASP4_1	1526_Refametinib_3	erk_mapk	3_180647255_T_TA
263	PPFIBP1_1	1526_Refametinib_3	erk_mapk	3_180647255_T_TA
264	PRRX2_1	1526_Refametinib_3	erk_mapk	3_180647255_T_TA
265	TADA1_1	1526_Refametinib_3	erk_mapk	3_180647255_T_TA
266	FBXO15_2	288_WHI-P97_3	other	22_22643666_C_G / 22_21127217_C_G
267	RPRD1A_3	263_FR-180204_3	erk_mapk	15_23364657_T_G / 4_190079171_C_T / 15_64381446_G_A
268	HS3ST3B1_2	273_CUDC-101_2	chromatin	15_42142087_A_C / 5_141432375_A_C
269	RBM39_1	286_KIN001-236_3	other	1_26457907_T_G
270	MRPS34_1	1014_Refametinib_2	erk_mapk	3_180647255_T_TA
271	PPARD_1	263_FR-180204_3	erk_mapk	15_25177023_G_C
272	TRIM29_2	1142_HG-5-113-01_2	abl	12_94248247_C_T / 15_50747694_T_C
273	SLITRK3_2	310_YM201636_3	other	12_52771095_C_G / 1_26457907_T_G
274	AOX1_1	185_Linsitinib_2	igfr	6_151015603_C_G
275	WDR41_1	281_Alectinib_2	rtk	2_217818534_A_G
276	WDR60_1	283_Omipalisib_2	pi3k	1_26457907_T_G
277	ELOVL1_1	136_Mitomycin-C_1	DNArep	22_24252424_G_C
278	ISYNA1_1	263_FR-180204_3	erk_mapk	8_22080213_T_C
279	BTBD17_1	281_Alectinib_2	rtk	1_26457907_T_G
280	E2F6_1	281_Alectinib_2	rtk	1_26457907_T_G
281	REEP5_1	281_Alectinib_2	rtk	1_26457907_T_G
282	HIF3A_2	228_AKT_inhibitor_VIII_3	pi3k	1_26457907_T_G / 16_3027533_A_G
283	PLIN3_1	1526_Refametinib_3	erk_mapk	10_92024747_C_T
284	SLC25A43_1	1526_Refametinib_3	erk_mapk	10_92024747_C_T
285	NINL_2	185_Linsitinib_2	igfr	22_22643666_C_G / 1_26457907_T_G
286	ZNF232_2	281_Alectinib_2	rtk	5_141432375_A_C / 6_32040790_G_C
287	SIRT4_5	226_GSK1070916_2	mitosis	19_32862451_C_T / 19_32864163_A_G / 1_26457907_T_G / 15_89806436_T_G / 11_120298301_A_C
288	TP53BP2_1	228_AKT_inhibitor_VIII_3	pi3k	22_21127217_C_G
289	DLGAP1_1	263_FR-180204_3	erk_mapk	22_21127217_C_G
290	ELL2_1	228_AKT_inhibitor_VIII_3	pi3k	22_22643666_C_G
291	L3MBTL1_1	300_CX-5461_3	other	8_22080213_T_C
292	VCL_1	281_Alectinib_2	rtk	5_141432375_A_C
293	FOXN4_1	211_TL-2-105_3	erk_mapk	19_12391643_A_G
294	DGKD_2	288_WHI-P97_3	other	22_24252424_G_C / 11_62825464_G_C
295	UHMK1_2	344_THZ-2-49_3	cell_cyc	6_31710251_C_T / 6_31464043_C_T
296	ATG10_1	1091_BMS-536924_3	igfr	3_120173274_C_G
297	RTN4_1	1526_Refametinib_3	erk_mapk	2_87800520_G_A
298	ZBTB34_2	1091_BMS-536924_3	igfr	11_1244522_A_C / 6_151015603_C_G
299	TRAPPC1_1	1011_Navitoclax_2	apop	16_18896782_A_AAT
300	MAN1A1_1	263_FR-180204_3	erk_mapk	11_61744427_A_C
301	GPR155_1	281_Alectinib_2	rtk	22_22643666_C_G
302	NUP205_1	226_GSK1070916_2	mitosis	17_7604041_A_C
303	DFNA5_1	1526_Refametinib_3	erk_mapk	11_24729296_G_A
304	ESYT2_1	263_FR-180204_3	erk_mapk	2_119366546_A_G
305	ARRDC5_1	1067_CCT007093_3	other	1_112653574_TA_T
306	WWOX_1	185_Linsitinib_2	igfr	22_21127217_C_G
307	TTC12_1	344_THZ-2-49_3	cell_cyc	11_1246619_A_C
308	PHLDA1_1	263_FR-180204_3	erk_mapk	6_151015603_C_G
309	USP44_2	1526_Refametinib_3	erk_mapk	7_155711220_A_C / 15_69422319_A_C
310	PLTP_1	341_Selisistat_3	other	1_176800222_T_C
311	FOXK2_2	1526_Refametinib_3	erk_mapk	17_57105517_C_T / 17_57110197_C_G
312	ERRFI1_1	1372_Trametinib_1	erk_mapk	17_41820457_A_C
313	NCAPG2_2	1378_Bleomycin (50uM) _1	DNArep	17_40554659_A_G / 6_146599135_C_T
314	GNG12_2	1526_Refametinib_3	erk_mapk	4_42616004_T_TA / 4_42616121_A_G
315	GTF2IRD1_2	185_Linsitinib_2	igfr	13_99295924_C_A / 16_4823959_A_C
316	CDH13_1	1526_Refametinib_3	erk_mapk	8_108228165_T_G
317	USPL1_1	1218_JQ1_3	chromatin	11_117206249_T_G
318	C8orf33_2	226_GSK1070916_2	mitosis	1_152805392_A_G / 1_152805488_G_A
319	LARP4_1	344_THZ-2-49_3	cell_cyc	19_21767500_C_T
320	WISP2_3	291_KIN001-266_3	other	15_34382849_C_T / 15_34382220_G_A / 15_34528441_G_A
321	ACTR3B_1	226_GSK1070916_2	mitosis	19_5680513_A_C
322	CACNA1H_1	1091_BMS-536924_3	igfr	1_26457907_T_G
323	KIT_5	1526_Refametinib_3	erk_mapk	19_55181918_C_T / 19_55185911_C_T / 19_55186384_AG_A / 19_55186398_T_A / 19_55186427_G_C
324	PFKFB4_1	1259_Talazoparib_3	g_integrity	2_48582490_G_T
325	PRKCA_1	226_GSK1070916_2	mitosis	14_39074610_T_TAAG
326	PPIB_1	310_YM201636_3	other	12_31206191_C_T
327	GUK1_1	1239_YK-4-279_3	other	3_184849291_A_T
328	TOMM20_1	263_FR-180204_3	erk_mapk	6_33315732_A_C
329	MCFD2_1	1526_Refametinib_3	erk_mapk	7_102356028_T_G
330	ARL2BP_1	1262_UNC1215_3	other	10_17122761_A_AC
331	DSTN_2	51_Dasatinib_1	abl	16_24750598_A_G / 16_24806184_C_T

Results of verification of biomarker responsiveness to sarcoma cancer drugs

No.	FRH	Var_Exp (pval)	Var_Drug (pval)	Exp_Drug (pval)	Ave_VarDrug (pval)	Rank
One	LUC7L_5	1.15E-13	1.91E-09 / 4.67E-09 / 2.52E-08 / 4.96E-08 / 6.43E-08 / 1.09E-07 / 5.42E-07 / 5.69E-07 / 6.37E-07 / 6.61E-07 / 7.24E-07 / 8.41E-07 / 9.74E-07 / 1.12E-06 / 1.30E-06 / 1.85E-06 / 2.11E-06 / 2.61E-06 / 4.14E-06 / 4.58E-06 / 4.71E-06 / 5.01E-06 / 6.19E-06 / 6.58E-06 / 8.57E-06 / 1.05E-05 / 1.13E-05 / 1.15E-05 / 1.30E-05 / 1.46E-05 / 1.53E-05 / 1.53E-05 / 1.59E-05 / 1.84E-05 / 2.07E-05 / 2.21E-05 / 2.43E-05 / 2.46E-05 / 2.89E-05 / 3.30E-05 / 3.88E-05 / 4.17E-05 / 4.23E-05 / 4.72E-05 / 6.02E-05 / 7.09E-05 / 7.70E-05 / 8.39E-05 / 8.89E-05 / 9.55E-05 / 0.000109598 / 0.000148946 / 0.000152384 / 0.000155038 / 0.000170866 / 0.000172159 / 0.000191632 / 0.000193261 / 0.000195059 / 0.000248358 / 0.000327687 / 0.000332153 / 0.000349439 / 0.000359765 / 0.00043352 / 0.000523494 / 0.000575856 / 0.00059693 / 0.000653698 / 0.0067536 0.001650567 / 0.001984983 / 0.002024319 / 0.00212417 / 0.002216293 / 0.002233734 / 0.00226 6673 / 0.002284694 / 0.002445929 / 0.002559027 / 0.002603948 / 0.002721712 / 0.002828387 / 0.003047476 / 0.003355885 / 0.004005854 / 0.004439654 / 0.004491468 / 0.004552462 / 0.005010534 / 0.00514149 / 0.005153885 / 0.005246181 / 0.005770832 / 0.005771327 / 0.006149630 / 0.006149164	9.24E-10 / 7.33E-07 / 1.80E-06 / 5.58E-07 / 5.49E-06 / 8.00E-06 / 1.11E-05 / 3.59E-05 / 2.57E-05 / 1.51E-05 / 0.000278643 / 1.29E-05 / 4.04E-05 / 4.27E-07 / 6.04E-05 / 1.36E-05 / 0.00095004 / 0.000354468 / 7.37E-05 / 0.000178107 / 1.81E-05 / 9.92E-06 / 2.90E -05 / 7.60E-05 / 0.000108534 / 5.28E-06 / 0.000909895 / 0.0001216 / 3.90E-05 / 8.71E-05 / 0.000177412 / 0.000229785 / 0.000206397 / 0.001303165 / 0.000336718 / 0.000220325 / 0.000794135 / 0.005242396 / 0.000138311 / 0.00012461 / 0.002555093 / 3.34E-05 / 0.000212185 / 0.000235135 / 0.003059306 / 0.002031234 / 4.10E-05 / 0.002839464 / 0.001941941 / 0.002111014 / 0.003734935 / 0.00088133 / 0.000260418 / 0.000159567 / 0.000217979 / 0.003045665 / 0.000711377 / 0.004950231 / 0.000568103 / 0.003370008 / 0.003370008 / 0.00032227 / 0.0047926 / 0.000154025 / 0.000752605 / 0.00142213 / 0.001031722 / 0.001286562 / 0.002164935 / 0.0003112 / 0.002677139 / 0.018218112 / 0.002277549 / 0.109175833 / 0.016662 693 / 0.019365546 / 0.002033578 / 0.003027991 / 0.006961933 / 0.025514886 / 0.024966968 / 0.005997059 / 0.001981323 / 0.029427464 / 0.012944297 / 0.01786683 / 0.037151491 / 0.001073091 / 0.000598838 / 0.061847574 / 0.007922021 / 0.022872712 / 0.0598484033 / 0.01228946 0.001105028 / 0.008624497 / 0.010968462 / 0.004721309	1.32E-03	105
2	FZD3_1	0.0000000028	2.0071481202007584e-05 / 1.3062838211579366e-05 / 0.00029640089162746337 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 4.559947241482223e-05 / 0.0003167991900078838 / 0.0097102439 -07 / 5.2109649171464235e-06 / 0.0005120167928359619 / 0.0005120167928359619 / 5.1570472200670454e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 1.615375160694009e-05 / 0.002238680629992204 / 0.0004073113752386311 / 0.004583801528895219 / 3.1219185299958266e-05 / 0.0002809149065890676 / 0.00043137964232097263 / 0.0011323441860117745 / 0.0005820808941317769 / 0.0004771627200779347 / 0.001077781567228248 / 0.005510243055764825 / 4.0242980256377906e-05 / 0.0014854545690578267 / 5.831891151164244e-05 / 0.001178242777327155 / 8.058554843717415e-06 / 6.9797948948972793e-06 / 0.03195616924078522 / 3.54688199707126e-05 1968 24071980226081e-07 / 0.003763661611010697 / 0.005510243055764825 / 0.0019333915490623197	4.399804084045925e-11 / 4.8538578704375377e-11 / 5.819712693031694e-10 / 2.963122656898289e-09 / 4.44134906876112e-09 / 1.7977709248154422e-08 / 9.42533011316618e-09 / 1.1148075349332164e-08 / 9.89017118210351e-09 / 2.876945828 8.244633671431711e-10 / 5.45137061905865e-09 / 1.8398488800553676e-08 / 1.804720713536623e-08 / 3.173412287913158e-08 / 9.525086920943969e-09 / 8.7889354451487e-09 / 4.116637231593234e-09 / 2.9588878898633333e-08 / 4.06509489616 2.8027611743995904e-07 / 6.8134604562299e-07 / 2.1399314856199655e-07 / 5.167422923449075e-08 / 5.613208935352902e-08 / 7.672478617521056e-07 / 1.6315736932712637e-07 / 2.4166361947108844e-07 / 1.451917420035471e-08 / 7.300226960 1.5352094129494146e-07 / 1.2282012910353222e-06 / 3.875740564606093e-08 / 1.0494748900823875e-07 / 6.763565198781288e-08 / 5.748334030450384e-07 / 3.353627284114995e-06 / 4.936480143362891e-06 / 2.623117317143412e40589 4.3859213486095075e-0 5 / 5.694315703855324e-08 / 1.2859395153980585e-05 / 5.4888376565657605e-06 / 2.7878746100826557e-05	0.001989712	45
3	LMBR1L_3	0.0000000000	1.3115991775009544e-05 / 4.285325077077582e-05 / 2.6206760013115565e-05 / 8.940710288311502e-06 / 0.00023367518351846944 / 0.00013454362830845267 / 2.7344476741525248e-06 / 0.00015924703665692674 / 5.3436977682081055e-06 / 0.0014252510660 / 0.0003390052340801507 / 0.00018791070326594343 / 5.476715755935002e-05 / 0.0006679513440066498 / 0.00027536436395942185 / 0.0007522453642716858 / 0.0004227612426053383 / 0.0006897961607062659 / 0.004578099476046143 / 9.144525988487157e-05 / 0.0002954537200985898 / 0.0003409317530540561 / 0.00022273590395933135 / 9.752428481242424e-05 / 2.7031767322445152e-06 / 0.0025088064616324564 / 0.0017094647117891196 / 0.0002960302092991554 / 0.001425251066430146	2.4878867617785033e-08 / 5.567969153038763e-09 / 2.2333257462478582e-06 / 1.5621435413932192e-07 / 8.122287757832368e-07 / 1.1594398210650143e-07 / 2.9535242848860537e-07 / 2.5457580110872606e-07 / 1.1054851619419285714-0657 7.434545034394883e-08 / 4.865301638318462e-07 / 7.955105981028123e-06 / 1.7636078112442492e-06 / 3.8772692803359075e-06 / 4.71942956895538e-06 / 7.710653232292368e-07 / 9.824959916701546e-06 / 2.626863984658229e-06 / 5.610135612369372e-06 / 1.985624144436174e-06 / 5.224149339178947e-06 / 1.1780186697477374e-05 / 9.265182617395918e-07 / 7.64885082423866e-07 / 2.3462097383522345e-06 / 7.599816951433106e-06 / 9.768824284806429e-0627 3.191552185410624e-05 / 8.929464106552106e-06 / 2.387431583758606e-06 / 9.679020756011901e-06	0.000605756	34
4	ACTN2_3	0.0000000000	1.6547061876174137e-09 / 7.813308929582946e-09 / 1.3841014381780992e-08 / 7.203525855071736e-08 / 1.8450442549499973e-07 / 3.911794473620475e-08 / 1.4114679221229936e-07 / 0.00012290638155137984 / 3.925563562928499e0669 06 / 1.4592559377242048e-06 / 3.2260283767681983e-07 / 1.193290985948489e-06 / 3.129728827401602e-07 / 5.1156576790479636e-06 / 2.2015209230331294e-05 / 9.735933136603846e-06 / 3.163985594214517e-06 / 3.9350506664998660 07 / 1.545453068208723e-06 / 4.094608902301485e-06 / 6.287076933306607e-05 / 8.143883852558403e-05 / 1.7745606348891978e-05 / 1.9064246508411654e-05 / 3.914526751739124e-06 / 0.0008320152992610897 / 0.00014766547542325887 / 1.07008905253 / 3.456388577880954e-06	8.346739914919394e-10 / 2.6568139110468435e-10 / 1.4297929266679253e-08 / 1.407569556254511e-08 / 7.425827856215124e-09 / 6.044864807461728e-07 / 4.09575569135761e-08 / 2.5796549872310057e-06 / 9.727443509821518e-06 / 1.821337487108634e-07 / 1.1858667937809359e-06 / 3.0908955186716785e-06 / 3.9399829491464125e-06 / 7.557297698538621e-07 / 1.0224109644328716e-05 / 9.68241332215864e-06 / 5.610135612369372e-06 / 7.333671574889317e-06 / 1.60178 1.0121247355306893e-06 / 4.744377470169944e-06 / 4.290604050280735e-06 / 4.1558712164911445e-06 / 4.452894368538964e-06 / 3.298618443622974e-05 / 5.383699135825628e-06 / 5.133532807266582e-06 / 7.79534870420108e-06 / 7.898719458534555e-06 / 4.382658462880079e-06 / 1.2453763214764084e-05	4.29939E-05	33
5	UBXN7_2	0.0000000085	1.2294933823319138e-07 / 0.0009528394445576896 / 2.5977106349140097e-07 / 4.438966867654239e-06 / 4.175847453807821e-05 / 2.2989177020843574e-05 / 1.0258657437467221e-05 / 6.35563211244946e-07 / 9.34271970438383e423_06110 / 6.0398819534333666e-05 / 0.0008312382650131915 / 7.10198962884777e-05 / 0.000737382769650959 / 0.00010754182303257409 / 0.0008657599149476789 / 2.064971477980467e-05 / 0.0021438374376241726 / 0.00011799868875755327 / 6.71344961405297543-05e 7.202281209470204e-05 / 0.0016679197649297247 / 0.0007630126686111583 / 0.00014077366120352972 / 0.0011908689867155006 / 0.00014493182389933843 / 5.074180415291073e-06	1.3148237968215948e-08 / 1.0058181189300685e-08 / 2.866158880903668e-07 / 3.321317019211789e-07 / 2.534746351463287e-07 / 6.649001393280087e-07 / 2.0062892730841753e-06 / 3.0760538337201583e-07 / 1.0537432811773585e4907 2.5056723004222252e-05 / 1.1607897314120808e-06 / 3.6896905862079686e-06 / 2.3529977016400513e-05 / 4.07908271138199e-05 / 2.233895897066247e-05 / 3.9901071706105935e-06 / 9.246191514674586e-06 / 2.970908809716153e-05 / 1.8686 2.7158231870787934e-06 / 2.8767737648395844e-06 / 0.00018285226698360374 / 3.2329494806633123e-06 / 4.56486535636156e-06 / 4.367493381976092e-06 / 2.3915904995124888e-05 / 4.7400303970179404e-05 / 5.693865725616807e9306 / 1.52 05 / 1.901917225424515e-05 / 9.246191514674586e-06	0.000537587	33
6	TRAM2_2	0.0000000000	3.4192931304829014e-06 / 1.3401582342156554e-08 / 4.659755401849588e-08 / 3.633081984870721e-07 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.3942380334535833e-06 / 2.0535846739106096e-05 / 7.359704703027111e-07 2.2255804 5.5806145526532266e-05 / 4.592877446409494e-06 / 4.592877446409494e-06 / 1.8937125547570738e-05 / 0.00021267966425080588 / 0.00095500393558891 / 1.6992771909182382e-05 / 5.326859676055172e-06 / 0.00020111609082546164 / 5.84826453375e / 4.835640776889601e-06 / 1.017482106342708e-05 / 0.00036820277558262876 / 2.3498756278510995e-06 / 6.031057779485052e-06 / 4.602166722353917e-05 / 4.77141612260032e-05 / 7.647399823593637e-05 / 1.3010063548672435e-05 / 5.70093445	4.322589807838839e-10 / 1.0710488778074884e-09 / 2.2541585510298175e-09 / 1.567254897199143e-09 / 5.8397941769315956e-08 / 1.0411408006909947e-07 / 1.5621435413932192e-07 / 2.6273639848288776e-07 / 7.180942105428594e-08 / 2.84165763 1.75722450249221e-07 / 5.273247808971176e-07 / 2.5292802828220107e-07 / 3.6227709430270065e-07 / 3.9578672189598e-07 / 7.272069346106795e-06 / 3.1693546387669756e-07 / 8.122287757832368e-07 / 6.365489980748545e140 / 07728 5.5398839416627e-07 / 2.1048201026388255e-08 / 4.694603023798112e-06 / 1.2067933247814594e-06 / 1.9510165024642392e-06 / 1.228062366600316e-06 / 3.739290293217579e-07 / 2.595574803350586e-06 / 7.308783057822739e-06 / 3.561518 4.694603023798112e-06 / 1.9523949703929863e-06	6.76165E-05	32
7	CDK13_2	0.0000000046	1.3853996990825065e-07 / 5.7745918340825286e-08 / 1.047470062062923e-07 / 3.956087072154918e-06 / 4.7520049447710837e-07 / 8.531496260442106e-08 / 7.3804316374052654e-06 / 4.47869272440367e-06 / 1.3463919058643852e-06 / 121123 3.6878940499153197e-07 / 0.00016082587811719362 / 0.00011322141355414124 / 0.0008207792485387008 / 0.0012079337533688077 / 2.9520572987073497e-05 / 1.140318186185745e-06 / 7.232001821345798e-06 / 8.539102875978968e-07 / 4.4499857317195 853e08 -06 / 0.00015124776392064736 / 8.137865842046858e-07 / 8.776477751355082e-06 / 7.3804316374052654e-06 / 2.5501614319254746e-05 / 6.930572497830363e-05 / 9.349083309404483e-05 / 3.4999466370498394e-05 / 8.383566724982507e-05	8.041496040856773e-10 / 1.1212152252396135e-09 / 2.2149509398591615e-09 / 6.49921859944133e-08 / 1.146609360749861e-08 / 9.315547292848514e-09 / 7.076208121664563e-08 / 1.5105555334027616e-07 / 1.4275728512486712e-07 / 3.39980967 1.7384894474420941e-07 / 1.7501056125582978e-07 / 1.6481167858879217e-07 / 7.741434363358432e-07 / 1.5033075637026901e-06 / 2.258352385302198e-06 / 1.0175118608827892e-07 / 1.054741547163592e-06 / 7.6950131270099130707 1.1584887732120262e-06 / 1.8682249268554782e-07 / 4.110133905921353e-07 / 2.4667255985252546e-05 / 5.724946196061661e-07 / 4.748434316553696e-06 / 6.535278991184282e-07 / 1.477642900652424e-06 / 3.526294982097946e-76 / 76763 2.387431583758606e-06 / 2.412245892896333e-05	8.92798E-05	32
8	BCL11B_3	0.0000000011	2.1691780926743226e-07 / 8.225833660011401e-07 / 1.789237622088428e-06 / 2.0356690840892754e-08 / 3.987613565444208e-05 / 9.360516011381817e-06 / 8.9395947547362e-05 / 3.466378757720392e-06 / 1.2385647799184097e-05590 0.00028446811679125046 / 4.3322170131610347e-07 / 3.6694829495818446e-05 / 1.3319185354685384e-05 / 0.0001450120364959482 / 0.0012382643384124116 / 0.00011198347385438923 / 1.2225430006781737e-05 / 2.2121210908325923e-06 / 0.0041340374259435115 / 0.00038512818063312726 / 0.00330460988510783 / 0.0011551309927923857 / 0.004248586177433409 / 8.696575941061198e-06 / 0.00035640811201797775	1.4826443090493311e-08 / 2.2740294469952764e-08 / 6.336269186082428e-09 / 3.539172375371934e-08 / 4.7609504610906553e-08 / 1.7960393747350935e-07 / 4.4916588042332195e-07 / 4.870463435270994e-07 / 2.0751734487343673e08 2.613509065423129e-07 / 4.2998193211784016e-08 / 2.9189015908569146e-07 / 7.796320698489975e-07 / 3.287953600510885e-07 / 4.184506818533476e-07 / 3.425164804138365e-07 / 2.6927928108537883e-07 / 1.5690808649462252e7461 1.3924361879300207e-06 / 1.895443350505234e-06 / 2.370093060682893e-06 / 3.622834973607711e-06 / 3.7283263548613296e-06 / 6.922058937247929e-06 / 2.3405099437428686e-05 / 0.00010413370355979186 / 1.2402625610892681e-05 535e 06	0.00058073	31
9	LONRF1_4	0.0000000000	2.3042263304124516e-06 / 8.182623816859019e-08 / 7.449035561194172e-08 / 3.271165707863933e-07 / 3.872601102158526e-06 / 8.238465335223179e-05 / 1.020006295103392e-05 / 4.780055898330748e-05 / 6.0132262668712315e-0594 0.0062583380 05 / 9.377014819070716e-08 / 1.8750944559946824e-05 / 0.0002257748867625031 / 4.61034011703085e-05 / 6.434547053133198e-06 / 0.0024160298697904117 / 6.16484303738615e-05 / 6.232941894500062e-06 / 8.832466534601092e-05 / 0.0073457393 -05 / 5.3959564521511103e-05 / 8.545068477488772e-05 / 0.0010681118057163815 / 0.0006404527227598945 / 0.0010528904729959797 / 4.7004221317801894e-05	2.871690193004347e-09 / 7.780203727430123e-11 / 1.1090993827240565e-09 / 4.885836011088783e-09 / 4.3845626278981783e-08 / 3.800967952270995e-08 / 6.548683737212715e-07 / 9.934081050522841e-07 / 1.225883649817038607 9.84639797132252e-07 / 1.0962753584080669e-07 / 2.504876298772149e-06 / 4.981808633338559e-06 / 9.170385978844389e-07 / 3.2430481749669908e-06 / 5.197036451631831e-06 / 2.542113471225459e-06 / 2.116056737675851e 3.74526002970195e-05 / 3.3592564682108814e-06 / 6.814920333363255e-06 / 3.2430481749669908e-06 / 6.4967649552906986e-06 / 4.180561542903392e-05 / 3.3264582250052445e-05 / 8.095222217568488e-06 / 6.77844689688323e-05	0.000225153	29
10	NUDT16_1	0.0000003288	2.7109747094287326e-07 / 5.2109649171464235e-06 / 9.224071980226081e-07 / 0.0004422271229621968 / 1.3062838211579366e-05 / 0.004583801528895219 / 0.0004771627200779347 / 3.2501044823812903e-07 / 5.2109649171464235e-06 / 0.00148545979797979797 05 / 0.001077781567228248 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 5.831891151164244e-05 / 0.0005120167928359619 / 4.559947241482223e-05 / 9.289397717877934e-06 / 0.0004073113752386311 / 0.017443989828652796 / 0.00025640470531304635 05 / 1.615375160694009e-05 / 3.54688199707126e-05	5.385967484932456e-09 / 1.0900516853889578e-07 / 4.2678416681249765e-07 / 6.789788444310893e-08 / 5.701290417865207e-06 / 9.053292911304865e-07 / 8.186772624145206e-09 / 6.986597395696305e-07 / 9.299566826975888e-06 / 1.222 3.519975525761359e-06 / 3.6551366345535073e-06 / 1.0585574831405579e-05 / 5.818012600528764e-06 / 8.591203793133295e-06 / 9.316488159288118e-07 / 1.764956512450499e-05 / 2.1357679726611226e-06 / 9.093604943452581e-06 / 1.5567150 3.245778635071659e-06 / 6.404889387734338e-06 / 4.079221141533871e-05 / 9.199981706216294e-06 / 4.3364053194329025e-06 / 2.601132064226823e-05 / 1.533327496967292e-05 / 2.2421339006083023e-05 / 2.984896137178954e-05	0.001015531	29
11	BDKRB1_1	0.0000021162	2.051237402337122e-05 / 0.0002944288613709527 / 1.1263759452799203e-06 / 0.005398390884784092 / 0.00014547367344876742 / 0.0008581803853921776 / 9.971939174478468e-05 / 0.0001395680222164631 / 0.0005345324666238675 / 0.0026702661426604127 / 0.0036790499750236597 / 0.00036105139567184824 / 0.004298857351174951 / 0.0003301911422383287 / 0.006072266622156599 / 0.0028963504457353837 / 0.0008619933402586612 / 0.0014783442733670397 / 0.002082636216901017 / 0.0038265104822853674 / 0.0012393227037226365 / 0.0001249119186090808 / 0.0014783442733670397 / 0.009354429645569597 / 6.267778266652492e-05 / 0.0010353911778693099 / 0.0067509647795811235 / 0.00017366806695686554	7.120406194930282e-10 / 1.3196888168609393e-07 / 9.697204620602088e-09 / 1.088769714704053e-07 / 7.422682196769718e-08 / 6.17052942560377e-06 / 1.3710585742644193e-06 / 3.457696931263268e-08 / 2.6405169262238316e-06 / 1.0362770769 1.460759694934436e-06 / 3.8350091086392213e-07 / 1.266977339256832e-07 / 5.261863247063795e-07 / 1.698316254132078e-07 / 2.8478812173765797e-06 / 3.786868009340554e-07 / 1.8874782131634276e-06 / 5.371804546576567e0707 9.483756578219822e-07 / 2.805248379242514e-07 / 2.019377115873876e-06 / 2.662855068818181e-07 / 2.339150064869274e-07 / 3.069489887698277e-07 / 2.1398422229289988e-05 / 3.835974713623205e-06	0.002009613	28
12	ACVR1B_1	0.0000000083	9.289397717877934e-06 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.224071980226081e-07 / 5.1570472200670454e-05 / 8.058554843717415e-06 / 0.00043137964232097263 / 0.0004771627200779347 / 0.0005120167928359 / 0.004583801528895219 e-05 / 0.00299921656722761 / 3.54688199707126e-05 / 0.00029640089162746337 / 0.0004073113752386311 / 4.0242980256377906e-05 / 4.559947241482223e-05 / 0.0004422271229621968 / 5.2109649171464235e-06 / 5.2109649171464235e-06 / 4.0242910407	1.998372850901874e-09 / 1.0776011928357113e-07 / 5.6474630649123774e-08 / 4.2739967072439055e-08 / 5.763039230727411e-08 / 9.002284340324614e-08 / 7.938422465642845e-08 / 1.2831192229268504e-09 / 7.481479973456353e753 / 07 1.5568 1.3255462641590073e-07 / 1.2540923765124735e-08 / 1.1641859357749167e-06 / 6.487275081622067e-07 / 6.067873978076284e-07 / 4.061559955180453e-06 / 3.085926641657104e-07 / 2.1304437118144328e-07 / 1.614987656365666e-06 / 1.6505215 1.100046276296759e-07 / 7.257376518723062e-08 / 6.752087125171909e-06 / 5.013481886934968e-07 / 7.94905114529822e-06 / 2.0096587893651723e-06 / 1.4098818268841097e-06	0.00054563	27
13	FUCA2_5	0.0000000000	7.326897656479634e-08 / 6.283050277058581e-07 / 6.33011695404466e-08 / 1.557810894407547e-08 / 1.4405701094138483e-07 / 8.973492705988831e-07 / 1.2247130912164364e-05 / 1.615099681752137e-08 / 1.0657346371809004e-06 1.9131942692024663e-06 / 1.7122549667747245e-06 / 1.8435980433182962e-05 / 1.6062625517222244e-05 / 2.1026075258297646e-05 / 4.784284498191245e-06 / 5.047975911248677e-07 / 3.7790277202725207e-05 / 0.000270963272846968809 06 / 1.2637608316913067e-05 / 3.318559639876234e-05 / 0.00019702583169390873 / 0.0001046372470755123 / 1.6587047672491597e-05	2.695852819501535e-08 / 2.244217853888235e-07 / 2.1408641399345624e-09 / 4.459485961371418e-08 / 6.368941796707181e-08 / 1.6401205520911236e-06 / 9.97301936759034e-07 / 1.213349385759083e-08 / 8.60619982006544e-07 / 6.5421822 2.4706785728123763e-06 / 2.8446904316163366e-07 / 3.1535389731478223e-06 / 4.116049846272149e-06 / 2.7284438670428954e-06 / 1.3028596303113042e-06 / 8.126089203342205e-06 / 1.927097516170564e-06 / 8.31845006069511e250 / 2.6e 3.954576249334482e-06 / 2.2796504010207573e-06 / 2.8025242380326764e-05 / 3.9907455715014176e-05 / 1.0808234857902164e-05 / 1.4622833564552763e-06	3.05171E-05	26
14	ZNF862_2	0.0000000000	5.757970402201313e-07 / 2.4029731505743387e-06 / 3.4338370713294263e-06 / 8.969803817399693e-06 / 3.673072285712733e-05 / 3.335194286983359e-06 / 9.35679667115326e-07 / 2.4638369795534228e-05 / 9.857812985592748e06 4.252860467065013e-05 / 9.555888578983361e-05 / 2.9781866792031246e-05 / 0.0001422310318318236 / 2.0739253861638837e-06 / 2.0842424513236034e-05 / 0.0001466471398885516 / 1.960392177885001e-05 / 0.00014017916355145386 / 3.5078700784406 / 2.4179541415210912e-05 / 4.771691927687007e-05 / 0.0018357138624291076 / 0.0004214818735639107	6.669284403690585e-09 / 1.0986500719843909e-07 / 1.2920530726355395e-08 / 7.144193992690255e-07 / 8.897098518847435e-08 / 2.143448052078468e-07 / 1.1024290553572537e-07 / 1.4570264791055579e-06 / 5.394353982216976790787 4.261784119390405e-06 / 3.913300846178839e-06 / 3.851296907021924e-07 / 1.3419887854662606e-06 / 7.36330097877341e-07 / 6.509968171609093e-06 / 6.683327596452262e-07 / 2.3915368068802614e-06 / 6.713901833795875e-06e 1.4047060577114316e-06 / 1.484859827728269e-06 / 2.9956513765454837e-05 / 1.3836812552345798e-05 / 1.8400365047125074e-06 / 2.8632422146042694e-05	0.000119677	26
15	JAKMIP2_1	0.0000003136	1.887107728600381e-05 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0001432193232982916 / 0.0002441254991542676 / 0.006227948945630897 / 0.0003000003635118199 / 0.003136344446815041 / 0.0010434554869778357 / 0.001424661642376461 / 0.0004963923899259765 / 0.00011484315511043709 / 0.0011412468921657625 / 0.00033206653362091303 / 0.0011737393453168934 / 0.00021988598115354305 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0007934067413946306 / 0.0007228851823325908 / 0.0003242200414121999 / 0.0033705319486407362 / 0.0020865035640383737 / 0.004284102869708787 / 0.001710012299865077	1.5055398107137094e-08 / 1.1317898810241505e-07 / 3.014192988473054e-07 / 6.562524735452552e-07 / 1.2620827414204395e-06 / 1.3813768678383736e-05 / 3.0528002185491916e-06 / 4.084105074757677e-06 / 1.276826259182333463506 5.301506195235781e-06 / 3.73908096007415e-06 / 2.881552294460198e-07 / 3.7090918031637474e-06 / 8.877144806640423e-06 / 1.0731167574000379e-05 / 4.60217321009711e-06 / 3.1972497431176806e-06 / 7.72630923511333e-06 / 7.78830923511333e-06 / 9.788 1.694391766170071e-05 / 1.9122978701285485e-05 / 2.1160442665025628e-05 / 0.00012419843212817223 / 3.665339330112523e-05	0.001203905	25
16	RHBDD2_2	0.0000000381	1.3853996990825065e-07 / 4.7520049447710837e-07 / 3.956087072154918e-06 / 1.280613569121123e-06 / 8.539102875978968e-07 / 2.5501614319254746e-05 / 0.0005420861101080113 / 5.7745918340825286e-08 / 8.776477751355082e-06 / 0.0073697720 e-06 / 1.140318186185745e-06 / 7.232001821345798e-06 / 3.9201554157572025e-06 / 4.4499857317195853e-07 / 6.930572497830363e-05 / 1.047470062062923e-07 / 0.00019163973853294472 / 7.3804316374052654e-06 / 3.6878940499153197e08 / 0.0012079337533688077	1.3993846023737915e-07 / 4.7782451098120726e-08 / 1.34825995314718e-07 / 9.277238538824435e-08 / 7.956677787090288e-08 / 1.9225900129783712e-07 / 4.7263934234281247e-07 / 4.706709396786997e-07 / 6.949261184656789e-07 / 7.829247 5.071860028688062e-06 / 6.993311385406026e-06 / 1.4497257721405869e-06 / 1.0714836567004093e-06 / 1.4372683450836863e-06 / 4.455852411812759e-07 / 1.815987875798767e-05 / 5.0475687702261924e-05 / 2.8193572587039603e77 9.053292911304865e-07 / 7.583935924635759e-06 / 9.83485693819911e-06	9.91481E-05	23
17	NELL2_2	0.0000000034	1.6974372024295342e-05 / 6.21390552863653e-07 / 7.492219023207615e-07 / 0.00033397296479027066 / 6.419532166056714e-06 / 3.680752556412065e-06 / 2.702881264505673e-05 / 0.0001892136695208884 / 0.00013627250802194024 / 4.7592039918405816 6.893999398193879e-07 / 2.7044709406151057e-06 / 1.030767276264569e-05 / 0.00011664561575068539 / 7.396819433180742e-05 / 0.0033003547134611197 / 0.0007339964856567068 / 3.212738000062656e-05 / 5.509863153367014e-05 / 0.00141345655091	1.805210992172401e-08 / 1.036277076972443e-06 / 1.6727928235519174e-05 / 1.3595686728091487e-05 / 3.109078579168171e-07 / 2.9751938937015323e-06 / 3.0194508969201275e-06 / 1.6481167858879217e-07 / 1.0183622735900536e-06 / 2.5513434 8.778520319265194e-07 / 4.509011181702684e-05 / 3.1588674679295282e-06 / 4.870956378452621e-06 / 4.222740574602922e-06 / 9.393121861778026e-06 / 5.533180942415662e-06 / 2.6252332329450155e-05 / 8.461228664041275e-0611297130 5.2787519047573424e-05 / 2.9042216064749748e-05 / 4.1781335008242154e-05	0.000322735	23
18	LIPI_3_23	0.0000000000	8.447946079053626e-08 / 1.205208755759072e-06 / 4.854502381230392e-07 / 2.1301603555625764e-05 / 6.853246565784258e-06 / 2.1960012732279454e-05 / 2.6827365804354637e-05 / 1.2548296867935075e-05 / 0.0002009891841455023 / 4.514325 05 / 3.312532784218011e-05 / 6.011489855493573e-07 / 0.00014831370330060418 / 1.7445373847640036e-05 / 0.004714448601828642 / 0.0032002760896811776 / 0.0004620869369249564 / 0.0003755600058949459 / 1.2884839156193493e-05 / 0.001151273616214569613	5.468987072460599e-10 / 2.6158726903289238e-08 / 3.565426338432271e-08 / 8.478661382630348e-07 / 3.875609327625631e-07 / 4.840300983601908e-07 / 8.703948887755087e-07 / 9.72132002734069e-07 / 6.098991982334273e77607 1.739637519533283e-05 / 3.2315430831611734e-06 / 8.154288030550316e-08 / 3.3855189139433126e-06 / 1.76044274336364e-06 / 3.077281478322042e-06 / 7.717215517819916e-05 / 3.986852616595454e-05 / 0.0001488041159355547 / 4.81219243547 05 / 2.5976982501110966e-05 / 1.2619626971823594e-05	0.000505799	23
19	RUNX1_1	0.0000001763	3.2501044823812903e-07 / 9.2240719 80226081e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 0.005510243055764825 / 0.00193339154906231231 / 2.408755304649635e-05 / 0.0005120167928359619 / 2.710974709423062807 / 0.0006200425273220967 / 0.00029640089162746337 / 5.2109649171464235e-06 / 8.058554843717415e-06 / 5.2109649171464235e-06 / 0.0006813940301036226 / 0.0003167991900078877 / 5.831891151164244e-05 / 0.0017723102864169204 / 6.979794879972793e	1.1641966632063906e-10 / 7.92535031547177e-09 / 5.753632350484074e-09 / 1.0677978948737271e-07 / 3.665113066608255e-07 / 1.4992785773118291e-06 / 1.2569627975426034e-06 / 4.294667785263063e-07 / 2.58629690488761e007 2.7175791335738627e-06 / 5.643067361003201e-07 / 1.7425168489071174e-06 / 1.244203208123666e-06 / 1.3319999198783528e-06 / 7.864816120590302e-08 / 1.998199593822845e-07 / 3.4658375428977435e-06 / 1.228062366600316e-06 / 1.35964405 1.714256584966273e-06 / 4.1558712164911445e-06 / 1.5033075637026901e-06	0.00051678	23
20	UGT3A2_1	0.0000012269	9.224071980226081e-07 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 6.979794879972793e-06 / 0.0003167991900078877 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 8.058554843717415e-06 / 0.00040731137 e-06 / 0.0005120167928359619 / 3.54688199707126e-05 / 0.0019333915490623197 / 9.224071980226081e-07 / 0.017443989828652796 / 1.615375160694009e-05 / 5.2109649171464235e-06 / 5.1601659937199475e-05 / 0.00029640089162746337 / 0.00193339154154	1.381799790744931e-09 / 1.805210992172401e-08 / 9.694448730531385e-08 / 4.403550218821958e-07 / 2.9355105945215545e-08 / 1.045969028083387e-07 / 3.835974713623205e-06 / 2.3222021704967167e-07 / 4.773025688625418e-08 / 9.343660 3.6689667424468134e-07 / 2.4140542299703294e-06 / 3.1276785123692046e-07 / 5.018595857384795e-07 / 2.387431583758606e-06 / 1.0035560526801471e-07 / 2.2657213911761568e-05 / 1.0022702721591722e-05 / 9.972925901562962e-06 / 1.805 1.554298505895915e-06 / 2.5796549872310057e-06 / 4.9185008634943495e-06	0.001005204	23
21	SLAIN1_2	0.0000000001	1.3401582342156554e-08 / 7.359704703027111e-07 / 4.659755401849588e-08 / 0.00012785013168945162 / 3.4192931304829014e-06 / 4.592877446409494e-06 / 5.207246052888057e-07 / 3.633081984870721e-07 / 4.05395891219117e-07 / 4.63640889 05 / 2.225580423517811e-06 / 5.326859676055172e-06 / 2.0535846739106096e-05 / 1.3942380334535833e-06 / 1.096889887353167e-06 / 4.77141612260032e-05 / 4.592877446409494e-06 / 0.00011487199668000062 / 0.00021267966425080588	7.85839937243628e-09 / 4.2881222404900966e-09 / 4.232043687265545e-08 / 4.48703162941859e-07 / 3.401659596258682e-07 / 5.695617165978249e-07 / 3.159236368559607e-07 / 1.9077743153626155e-07 / 1.305430203445936e-0677 3.5948370 1.4937326562948882e-07 / 9.345028580131548e-07 / 2.9676196803014993e-06 / 2.4190454710072306e-06 / 7.316779637097216e-06 / 2.031054374651815e-06 / 4.1261024294080975e-06 / 4.360382079203378e-06 / 1.3128908636239939e-06 / 3.4828888	2.99622E-05	20
22	TRPM4_3	0.0000000003	9.196770242715937e-09 / 2.664719965991362e-08 / 3.725931030072998e-06 / 2.0944901905984007e-05 / 1.347120953229711e-06 / 1.0865942049799405e-07 / 0.00047815490214213265 / 9.236060166459222e-07 / 3.900469077615773e-06 / 8.121739906278 07 / 0.0042689591705948856 / 8.209562763309459e-06 / 1.5485664592082808e-05 / 2.1196123383966528e-05 / 3.5495647595004414e-05 / 3.8020455601505727e-07 / 1.8325658404407734e-05 / 1.9521118173804467e-05 / 3.311124664582957e06	2.1749725015902454e-10 / 2.0414050703934923e-08 / 3.1693546387669756e-07 / 3.0408081748624807e-06 / 9.653812249086853e-07 / 2.9355105945215545e-08 / 2.00027266182616e-05 / 2.7663883060711165e-06 / 5.405035911800092e-07 / 817 827 4.794639512641633e-06 / 7.1412649173752545e-06 / 1.0690993559290582e-05 / 4.620846133046724e-06 / 2.5629460029005674e-06 / 1.8751868580077024e-05 / 9.824959916701546e-06 / 6.0957425825213314e-06 / 2.2006142512020074e77	0.000245445	20
23	SLC24A3_1	0.0000000210	1.1263759452799203e-06 / 2.051237402337122e-05 / 9.971939174478468e-05 / 4.369070707050029e-05 / 0.00017366806695686554 / 0.0008581803853921776 / 0.00014547367344876742 / 0.0001395680222164631 / 0.0001249119186090808 / 0.0002944288613709527 / 0.0010353911778693099 / 6.267778266652492e-05 / 0.0006503983018257066 / 0.0012393227037226365 / 7.924407878618111e-05 / 0.0002944288613709527 / 0.0008619933402586612 / 0.0026702661426604127 / 1.7999540459370774e-05 / 0.0031060111248571412	6.407832325684251e-09 / 9.240926568058304e-09 / 9.966453961357818e-08 / 3.08922513577382e-07 / 8.520500454117749e-07 / 7.642146337997833e-07 / 2.5299574218373655e-07 / 7.330469554133431e-08 / 1.6814800128714516e-07 / 6.095742 2.9345983642597263e-07 / 1.0181132930253954e-06 / 3.4215164228215663e-07 / 4.6580022097987207e-07 / 8.830988008417038e-07 / 2.65171239271242e-06 / 2.322060799489299e-06 / 9.727443509821518e-06 / 3.786868009340554e-07 / 15027	0.000595951	20
24	NCKAP1L_1	0.0000001762	3.2501044823812903e-07 / 9.2240719 80226081e-07 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 4.0242980256377906e-05 / 5.2109649171464235e-06 / 0.0004073113752386311 / 0.00029640089162746337 / 0.0003167991900078877 / 5.21096491764 -06 / 5.1601659937199475e-05 / 2.7109747094287326e-07 / 0.0005120167928359619 / 8.058554843717415e-06 / 2.408755304649635e-05 / 0.0019333915490623197 / 1.3062838211579366e-05	7.9904530083348e-11 / 2.4994053567542328e-09 / 9.924736193254942e-08 / 1.8132622674092954e-07 / 1.4200503117731924e-07 / 2.069668183072629e-07 / 1.2682052722257146e-06 / 2.9447437356082395e-07 / 6.313636923660506e-07 / 4.4682920249147006e-07 / 1.7578808963170404e-05 / 4.263423766146041e-07 / 7.92201170417271e-07 / 9.008258721422489e-07 / 2.0908224860853314e-06 / 3.056396462394648e-07 / 1.3307689369536397e-06 / 5.9816062896412147959808	0.001056536	20
25	RAB32_3	0.0000000000	7.292182530573412e-05 / 0.0003225223870914812 / 2.2327691127733746e-05 / 0.00038393847007829764 / 3.886421476307484e-05 / 0.00013655060364162736 / 0.00024209823898958905 / 1.5637203423692577e-05 / 2.238208719127431e-05 / 0.0002565324608559 / 0.0003781658379275213 / 0.0039368730296373096 / 0.0023817198498238316 / 0.0021712362602544022	1.0130573619295235e-08 / 5.741020731646927e-08 / 9.202018333928226e-08 / 1.4025070456802076e-07 / 7.718777494211644e-07 / 7.407426548536711e-08 / 1.8556041703527292e-07 / 5.751375891322542e-07 / 9.654719902897998e0707 2.4077694825580987e-06 / 7.539024856072121e-08 / 1.4948990890785054e-06 / 3.549228834149341e-06 / 2.6963041058083467e-06 / 5.538818081011408e-06 / 9.408104215481871e-06 / 7.311276565893818e-07 / 5.17516813573647e-06	0.000814351	19
26	E2F5_1	0.0000004973	4.335544688590604e-05 / 0.0016610593752756947 / 0.00015165886425239433 / 0.0020037138718268558 / 0.0062926107897605076 / 0.008954836987534829 / 0.0013997024178051241 / 0.0017438515808585928 / 0.005852051539088946 / 0.0013991989944309945 / 0.0037308274054686026 / 0.001807326102912818 / 0.0014458717426393303 / 0.0006825622924508404 / 0.006160732768120326 / 0.008954836987534829 / 0.004687460046810221 / 0.0001360945704417454 / 0.0072609125485500695	2.612437800154611e-10 / 1.5925972264030232e-08 / 3.100531350503503e-08 / 6.448536988230897e-08 / 5.466544241455998e-07 / 3.2169896739895314e-07 / 3.1906789245845806e-06 / 2.3096174786096604e-06 / 1.0141504136839242e-06 / 2.260690937267 9.279972919171246e-07 / 2.847754855927293e-07 / 6.680245031011018e-06 / 5.490090984753377e-06 / 1.077519353313373e-06 / 5.376695975590836e-06 / 4.7530598444137695e-06 / 2.3590259977159812e-06 / 8.340398610953811e06	0.003387824	19
27	RBM11_5	0.0000000000	1.4526084780295787e-06 / 5.443773486089936e-07 / 1.1971991474232777e-05 / 6.91934628205793e-05 / 2.5796294158785155e-05 / 2.552372456547772e-05 / 1.829615188324561e-05 / 0.00032472688716174674 / 0.001180151638718015 / 4.2244922676716 -05 / 1.4103499755990336e-05 / 0.0008670088401703034 / 0.00038070130611975926 / 0.0007339140203518938 / 0.0002219001663689648	3.3998096773618356e-07 / 1.045969028083387e-07 / 8.800196900298445e-06 / 8.936798924355491e-07 / 2.208556405239799e-06 / 2.223017106257352e-06 / 4.845393516836826e-06 / 2.2421339006083023e-05 / 4.345707282768042e 8.025474759619109e-07 / 0.00010333461220899216 / 3.039816166758595e-05 / 1.0072708544500107e-05 / 1.0221468717522446e-05 / 0.0001719448294932468 / 8.296198213269645e-05 / 2.393187109770829e-05	0.000515791	18
28	JHDM1D_1	0.0000000465	1.887107728600381e-05 / 0.0019194247450850443 / 0.0010434554869778357 / 0.00021988598115354305 / 0.00011602560329098725 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0003000003635118199 / 88	5.957947041241642e-10 / 4.7213815560041737e-07 / 1.2953287867816182e-06 / 1.517275876808106e-07 / 2.0848690809316758e-07 / 2.1505701666588e-07 / 7.184717182652482e-08 / 3.4470235709692284e-07 / 6.582103467311211e-07 / 3.469012 2.581774969081794e-07 / 2.783019047305537e-07 / 2.2587138448042827e-06 / 3.436077993294023e-07 / 1.3808771629119943e-07 / 1.0777981400774649e-06 / 4.837594802084705e-06	0.000703078	17
29	SDC1_2	0.0000000025	3.24920563754477e-05 / 1.3377106429420062e-05 / 2.286373051099475e-05 / 8.919615355047188e-05 / 0.00015487870247863725 / 0.0003070420132331339 / 6.552854468616073e-05 / 0.010204546359181573 / 0.0004579043420381389 / 0.0003133243150903811 06 / 0.0002836145894393715 / 0.0014642811488913923 / 3.349324237754571e-06	1.446249458351141e-08 / 1.1593366582600526e-07 / 1.8212505086597223e-07 / 2.805221831770931e-07 / 1.52555181061785e-07 / 1.3421491093673395e-07 / 5.838895464045765e-08 / 8.431612764947411e-07 / 1.4442373350859127e-06 5.355505538740775e-07 / 1.058510323843106e-06 / 6.635824670736839e-07 / 3.247865406241601e-05 / 4.51316772311888e-06 / 2.621113516811208e-07 / 1.9091723806799227e-06	0.000798393	17
30	ENPP3_2	0.0000000002	7.220251902586713e-08 / 1.5415033312027603e-05 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.864296167501907e-07 / 4.1398213999064624e-06 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 5.9617084438303865 1.2072926853768964e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.3398427589553948e-05 / 2.132615896596937e-05 / 2.4103457859893014e-05	1.9517835933891448e-08 / 2.248231048691535e-08 / 4.830482337300574e-08 / 1.481967113051988e-07 / 4.175954165049041e-08 / 1.6171122367004618e-07 / 1.6052769492778243e-06 / 4.900800780379338e-07 / 9.924621104960267e-566 / 5.843072350429807e-07 / 3.2579388947351196e-06 / 1.1836495389262217e-06 / 1.1411599622062492e-05 / 2.843023304997815e-06 / 1.828727174279431e-05	8.88611E-06	16
31	RBM33_1	0.0000000000	9.289397717877934e-06 / 3.2501044823812903e-07 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 2.408755304649635e-05 / 5.2109649171464235e-06 / 3.546 3.54688199707126e-05 / 0.0004073113752386311 / 5.1601659937199475e-05 / 0.00043137964232097263 / 4.0242980256377906e-05 / 5.2109649171464235e-06	8.944918223939934e-09 / 9.053698775288811e-09 / 2.5457122572689533e-07 / 1.5628889781375459e-07 / 9.626516148430137e-08 / 4.9661337040464625e-08 / 1.4653913639914694e-07 / 9.345028580131548e-07 / 1.2202889190119188e-07 / 206 3.4985449908631084e-07 / 3.210007225110076e-06 / 3.041361665158829e-06 / 7.856862302531046e-06 / 1.7638568513415927e-06 / 8.270219208624064e-07	6.93645E-05	16
32	MYOM2_1	0.0000000034	3.2501044823812903e-07 / 9.224071980226081e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 0.001077781567228248 / 05 / 0.0006200425273220967 / 5.1570472200670454e-05 / 3.1219185299958266e-05 / 0.0005820808941317769 / 2.7109747094287326e-07	7.84964801360265e-09 / 1.1586817234891624e-08 / 6.152115559989733e-07 / 1.6684003331859656e-07 / 3.958329447265834e-09 / 4.242888917541819e-08 / 2.859898115713063e-07 / 2.0425825542054087e-07 / 4.255278048064328e34 / 0729 1.2927770179758555e-06 / 4.840614386607516e-07 / 6.826429036349635e-07 / 3.953740273881905e-07 / 1.6027712459664707e-07 / 1.277864202481348e-06	0.000153777	16
33	ADRB1_1	0.0000010659	3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 5.2109649171464235e-06 / 3.1219185299958266e-05 / 2.0071481202007584e-05 / 6.979794879972793e670 3.54688199707126e-05 / 0.00299921656722761 / 1.3062838211579366e-05 / 2.408755304649635e-05 / 1.615375160694009e-05 / 0.0006200425273220967	2.5354833517437137e-10 / 1.2841215292330722e-08 / 3.315225754524024e-08 / 8.863210863839688e-09 / 2.599695216645358e-08 / 5.874422234352583e-08 / 2.2101941341811467e-07 / 9.580348649532748e-07 / 2.32003591797698e-0673 1.3425131 2.4253616535611087e-06 / 9.891342242857947e-06 / 1.1746244916516119e-05 / 2.092495310550426e-06 / 3.681660463815629e-06 / 1.4268112459432864e-05	0.000239944	16
34	FAM19A5_1	0.0000000251	2.051237402337122e-05 / 0.0001249119186090808 / 1.1263759452799203e-06 / 0.00014547367344876742 / 0.004362771524153584 / 6.267778266652492e-05 / 0.00036105139567184824 / 0.004298857351174951 / 0.0026702661426604127 / 0.000294428861370939	3.7316428195760516e-08 / 4.801672877175668e-08 / 2.2512706653969313e-08 / 2.2270178280725655e-08 / 1.1663586146149853e-07 / 5.1617837573062526e-08 / 9.920288294972892e-08 / 1.0628762332633252e-07 / 7.803934546881044e0707 3.618961161943627e-07 / 1.737206632640488e-06 / 1.114198886925796e-06 / 1.737206632640488e-06 / 4.390716794223026e-06 / 1.5851926645157727e-06	0.001409487	16
35	CDK6_2	0.0000001305	0.00013786395373714154 / 0.00012482662815781762 / 6.30950668542991e-06 / 3.539797690840022e-05 / 0.0021106959648809795 / 0.0019402604943496325 / 0.0004050172910570013 / 0.003362553960006399 / 0.0013208680612235583 / 0.00017037141729627674 / 0.00702600 780 625	1.9544766970910803e-08 / 3.902848227411897e-06 / 1.1734588197031495e-06 / 1.1118487852102413e-06 / 1.8215667472555084e-06 / 1.2168005067226621e-05 / 1.2378495979370532e-05 / 1.2610279737677179e-06 / 7.5858403127194657 1.4962029489277431e-05 / 1.155615785434093e-05 / 9.614370500489897e-06 / 5.003114862001264e-06 / 5.28580544479192e-05 / 1.4068709149077956e-05	0.002220337	16
36	C1orf54_1	0.0000004284	0.0014458717426393303 / 0.0020037138718268558 / 4.335544688590604e-05 / 0.0016610593752756947 / 6.184726372815994e-05 / 0.0001877376372184388 / 0.004687460046810221 / 2.6541144234526445e-05 / 0.0072609125485500695 / 0.00020855415394078816 / 2.305129761580506	4.431617867534599e-08 / 9.764176338067594e-08 / 1.6551951268345963e-08 / 5.4670195572463556e-08 / 8.693119479065898e-08 / 6.467247715906918e-08 / 1.3820781181904612e-07 / 2.601353524092188e-07 / 1.4346332512235168e724 2.1381221213988253e-05 / 2.0697206630187898e-07 / 2.0216248384142136e-05 / 1.3296295127951121e-05 / 4.089595896778703e-05 / 6.182750614867968e-06	0.003194747	16
37	HOOK1_1	0.0000000509	3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 9.289397717877934e-06 / 0.017443989828652796 / 0.0019333915490623197 / 5.2109649171464235e-06 / 0.0003167991900078877 / 8.006126 / 0.0004073113752386311 / 0.001077781567228248 / 2.408755304649635e-05 / 0.03666459832926511	6.576012762267339e-08 / 1.4455622042691941e-06 / 4.885610187770645e-07 / 3.76701623356669e-07 / 1.8059093721170035e-06 / 2.676171176620618e-05 / 5.749753783810232e-05 / 1.1638593888237151e-05 / 8.6335388114483390606 2.090650282526137e-06 / 2.5661246047916315e-05 / 1.5202656143498954e-05 / 9.9612781999649e-06 / 1.6231643656615e-05 / 0.00012445882667471073	0.003621722	16
38	EVI2A_1	0.0000000779	2.0071481202007584e-05 / 1.3062838211579366e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 0.0006200425273220967 / 3.54688199707126e-05 / 0.006968336904458093 / 5.2109649171464235e-06 / 99064 0.0006813940301036226 / 2.408755304649635e-05	1.5609086500143182e-09 / 2.4274791706684804e-07 / 1.3635987406508816e-07 / 1.6189487637413584e-07 / 3.704245549261797e-08 / 5.850917111819974e-07 / 4.021754229335225e-06 / 5.99711639772174e-06 / 5.939256052201768e-07 / 927 1.752058259452043e-06 / 3.3967361752805547e-06 / 1.4521128153120201e-05 / 2.839421384468485e-05 / 1.9278657989741134e-05	0.000856793	15
39	KDSR_1	0.0000003143	1.887107728600381e-05 / 0.0005437871552770366 / 0.002087197919276702 / 0.0001432193232982916 / 0.00021988598115354305 / 0.002087197919276702 / 0.0010434554869778357 / 0.0002441254991542676 / 8.177669445709026e-05 / 0.006227948945630897 / 0.00161934022383 88893	7.774619885339959e-09 / 9.17707137009986e-09 / 6.345932895218097e-07 / 3.824093835557216e-08 / 4.870463435270994e-07 / 1.781378071484659e-07 / 1.5486153095797136e-06 / 3.2667817640867473e-06 / 9.66394881627529e817 7.511357995471599e-06 / 2.1985427007215493e-06 / 4.469268122727537e-06 / 5.302698252478667e-06 / 5.826180628047725e-05	0.00108321	15
40	TRIM69_1	0.0000000466	1.887107728600381e-05 / 0.0002441254991542676 / 0.0001432193232982916 / 0.0004863107130580812 / 0.0001432193232982916 / 0.00021988598115354305 / 0.00021988598115354305 / 0.0005437871552770366 / 8.177669445709026e-05 / 0.0016193402238388898 / 0.006227948945630897	1.1433357759584753e-08 / 8.836349820396399e-08 / 1.0186144265985267e-07 / 9.978329579501906e-08 / 5.327953099928334e-07 / 2.0403148485445152e-07 / 1.36202730898669e-07 / 1.8476610323825603e-07 / 1.9599293797405736e62606 4.736723443537097e-06 / 3.824375400480388e-06 / 1.7111709589036534e-06 / 5.410761494405694e-07 / 1.1672532290928993e-05	0.001913028	15
41	FAM69A_1	0.0000000702	0.0013130417279779386 / 0.00015668136762185704 / 0.000580627296776329 / 0.00021513618339111576 / 0.0006379488254521119 / 0.0038002956245117296 / 0.00023863087793556863 / 0.009089976463332457 / 0.009732706737130784 / 0.0015596001225492795 / 0.0012028677089548085426 0.0079887	5.207979195444387e-10 / 2.3954906890799492e-08 / 8.376642315944637e-08 / 3.029086308872845e-09 / 8.2602839443737e-08 / 4.5432680388905903e-07 / 3.4215164228215663e-07 / 3.6227709430270065e-07 / 1.1119851588379871e-06456 9.884962 6.58864064133256e-07 / 1.9066424564105585e-07 / 1.0175118608827892e-07 / 9.736821003526402e-06 / 2.2836387735375516e-06	0.003082358	15
42	MCF2_1	0.0000000950	0.002107325343692074 / 0.0007073001228128905 / 0.0016226906289916678 / 0.013331886853589549 / 0.004410274724633273 / 0.004410274724633273 / 3.1219185299958266e-05 / 0.0011323441860117745 / 0.005133998810813905 / 8.807499017205126e-05 / 0.008672939675174894	2.8385942053147423e-07 / 7.000874559889031e-07 / 1.0191814816838582e-06 / 1.937510906526569e-06 / 1.219795851846249e-06 / 1.1273301221243648e-06 / 7.451700758866295e-08 / 4.510350188873355e-07 / 1.6503324272286632e419 7.86885268932808e-06 / 2.4523766799232255e-06 / 8.771491504288576e-06 / 4.472728712108301e-06 / 6.181222965809451e-06	0.004209327	15
43	DNMT3A_1	0.0000000038	3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 1.615375160694009e-05 / 9.289397717877934e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 5.1570472200670454e-05 / e-05 / 0.0003167991900078877 / 0.04025623380130843 / 0.016412811603890378	8.647692450087712e-10 / 3.609830399524262e-08 / 1.0850349172583042e-07 / 4.2367786991922625e-07 / 5.547034323026097e-08 / 4.995600154079587e-06 / 9.034850264291034e-07 / 1.1942660873924224e-07 / 3.47640466680970139406 4.064896475030508e-06 / 5.950697198132815e-06 / 2.1639192493163854e-06 / 0.0003267886041800874 / 2.5073506475872135e-05	0.005016004	15
44	RAP1GAP_1	0.0000001086	1.3062838211579366e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 8.058554843717415e-06 / 5.2109649171464235e635 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 0.0004073113752386311	1.0234263973416661e-07 / 8.919463455114289e-08 / 3.3072632243081114e-08 / 1.5105555334027616e-07 / 2.5836122972488502e-08 / 1.2756238211643116e-07 / 9.299416219218907e-08 / 2.1342000804921115e-07 / 7.37724046840261e70007 3.3529930477004465e-06 / 2.385355833544641e-06 / 9.364193044327943e-08 / 5.244484117278139e-06	4.06208E-05	14
45	GCNT1_2	0.0000000002	2.78484877909426e-05 / 4.864296167501907e-07 / 9.764023441666015e-05 / 2.140496501618477e-08 / 0.00016651089487352638 / 3.0074215404236193e-05 / 0.0006617980305097352 / 1.3483681400210042e-06 / 4.031241782169131e-05 / 1.1981309904 e-09 / 7.220251902586713e-08 / 3.539399887995572e-05	1.8148339446273985e-07 / 6.847165231186148e-07 / 2.165545875875814e-05 / 2.3188274882197003e-07 / 6.0280690987430294e-06 / 5.2750455191025595e-06 / 4.06671138458547e-05 / 1.2997762974345022e-06 / 2.217018783282958306-368 / 9.170085944984048e-06 / 1.1905756638522483e-06 / 5.8239343353291375e-06 / 2.5038906043292028e-05	7.59475E-05	14
46	ACVR2B_1	0.0000024645	0.004342013504637762 / 0.010062997503423064 / 0.01546878234616017 / 0.0043172887751955534 / 0.004147048109487421 / 0.0027366161949255864 / 0.004302356273800125 / 0.003851105873342487 / 0.010924554738209911 / 0.0034419337702655166 / 0.0016993523409038112 / 0.00881541006358	4.6969645977238944e-08 / 1.0646048244254027e-06 / 2.074984122638114e-06 / 1.6464210539762824e-06 / 3.55074742901801e-07 / 8.336014361253352e-07 / 1.0819897944403119e-06 / 6.649001393280087e-07 / 1.771560615564129e-07 / 2.1882250 5.884742871708681e-07 / 1.359935106570381e-05 / 2.757047405189331e-06 / 3.7316428195760516e-08	0.006036009	14
47	FLII_1	0.0000003706	0.013438701196916187 / 0.0013131196768949175 / 0.001313597832987636 / 0.010966427251690712 / 0.0010967995115722952 / 0.00283637665495315 / 0.020637719307260594 / 0.009544509177234737 / 0.011113919331766907 / 0.002612407689400646 / 0.00014659710165947198 / 0.0117431113167	2.0358630016163756e-07 / 9.38178289658818e-07 / 1.5768550290633048e-06 / 4.170842922005371e-07 / 1.2667845868111258e-06 / 5.267900245960507e-07 / 1.0328138955557601e-05 / 2.5703309767846595e-06 / 9.713959639172909e-0677 5.689594876108628e-07 / 5.210656857814663e-06 / 2.5072452506982253e-06 / 2.1338889654131307e-06	0.00796357	14
48	TGS1_1	0.0000000593	0.005817871625455744 / 0.001612584660708291 / 0.0053998526759721725 / 0.01862777129511709 / 0.0053998526759721725 / 0.01862777129511709 / 0.007245502894805505 / 0.0077845190703610834 / 0.006739142831934305 / 0.02903454585336941 / 0.04017463251009088 / 0.012410515410339	1.1383417891948003e-06 / 3.9578672189598e-07 / 9.316488159288118e-07 / 1.3710585742644193e-06 / 2.6082574074268862e-06 / 1.3166677315221278e-06 / 1.7045413888506067e-06 / 3.708237186148934e-05 / 5.818012600528764e06 2.2843722976730473e-05 / 8.803523078622629e-06 / 3.9399829491464125e-06 / 3.3285882689135296e-05	0.014553902	14
49	XG_2	0.0000000005	1.3401582342156554e-08 / 1.7203065067402312e-07 / 1.3942380334535833e-06 / 4.659755401849588e-08 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.017482106342708e-05 / 4.835640776889601e-06 / 2.349875627851099506-7353 7.359704703027111e-07 / 3.633081984870721e-07 / 2.0535846739106096e-05	1.9199076986833634e-08 / 5.521935167514162e-09 / 3.002088015685159e-08 / 1.1673991664313873e-07 / 2.339150064869274e-07 / 7.850967660487343e-07 / 4.37609121214664e-07 / 4.313448454057681e-06 / 4.476536711400614e-0673013 2.1997972567339213e-06 / 1.1288300480073834e-05 / 7.933567388992601e-06	4.70488E-06	13
50	PCDH17_2	0.0000000072	7.492219023207615e-07 / 1.6974372024295342e-05 / 1.6060512405884523e-05 / 3.680752556412065e-06 / 6.21390552863653e-07 / 6.893999398193879e-07 / 6.419532166056714e-06 / 0.00011541115360842292 / 3.212738000062656e-0584 603 e-05 / 1.030767276264569e-05	6.224247092494593e-07 / 1.908891295970431e-06 / 1.876118975664838e-08 / 6.86071862572385e-07 / 2.666345798254567e-06 / 2.440951781485953e-06 / 1.963413625423467e-06 / 2.0652089761761355e-06 / 1.494707065464428e-0614 8.28372335 7.600283334205516e-05 / 1.3148299792014698e-05 / 1.7938478170268224e-06	4.39826E-05	13
51	FCGRT_4	0.0000000001	1.6626318528356214e-07 / 4.1454120935946585e-08 / 1.2856777469915098e-05 / 2.655269050407992e-06 / 4.4947875774412546e-05 / 0.00076179506295693 / 8.948391869055381e-06 / 2.7424661803535043e-05 / 4.648680805728703e-06 / 1.91632420450747 06 / 2.5267554662269253e-05 / 6.405110910660664e-05	2.1372152215021398e-08 / 2.057088830240376e-08 / 5.269671774798225e-06 / 3.982312076585435e-06 / 2.495582032458844e-06 / 2.870333661857787e-05 / 9.483756578219822e-07 / 1.25762087754457e-05 / 9.76651146667424e-06 / 2.6617 1.3930567108132102e-05 / 1.1400150976360551e-05 / 2.349102225413189e-05	7.35514E-05	13
52	PPAPDC2_5	0.0000000000	4.5169034086855336e-09 / 9.742548139480632e-07 / 5.217506022585185e-05 / 3.5026216529567156e-06 / 2.4673093720667337e-06 / 5.3153783898022636e-05 / 1.3937823180284198e-07 / 7.982877170487641e-08 / 6.508221395478821e800 05 / 3.21116578085472e-05 / 6.01263079824308e-05	1.1212152252396135e-09 / 7.076208121664563e-08 / 4.726350666602277e-08 / 1.0531985708720735e-07 / 2.551343424529328e-06 / 1.7296428659338845e-05 / 2.9345983642597263e-07 / 8.883747046871617e-07 / 7.1695441364551825e9306 905 06 / 2.895020091940764e-06 / 9.487544302661349e-06	0.001561006	13
53	OTUD1_1	0.0000066678	0.0001143785517442608 / 7.116374713072327e-05 / 0.0013570458512569155 / 0.002178697316418811 / 0.0038052297192277813 / 0.0007240451812165356 / 0.0019400441864677392 / 0.0023946671170695885 / 0.011483919297924996 / 0.0019400441864677392 / 0.0011976310136393364 / 8.349404	2.4271728701188334e-07 / 2.716202606694871e-08 / 4.962003898295528e-07 / 1.3066402773912248e-06 / 2.94591397016505e-06 / 7.18702142240598e-07 / 1.4280279163673197e-07 / 7.547674557111806e-06 / 6.26163745905449e-06 / 6.44 5.452589541736924e-06 / 0.00036648972212703103 / 3.720187278061506e-05	0.002701445	13
54	IRS2_2	0.0000000037	7.220251902586713e-08 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.1398213999064624e-06 / 1.5415033312027603e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.4279427966735553e-05 / 4.864296167501907e08 5.7336006475198166e-05 / 5.9617084438303865e-06	2.2709629567530206e-06 / 2.0247353106423544e-07 / 1.3837713193741096e-07 / 1.0531985708720735e-07 / 1.1721035444282598e-06 / 5.783428499209018e-07 / 1.1344098678195103e-05 / 1.301499532725973e-06 / 8.452688032747793e0606 3.0574198226347985e-06 / 4.1558712164911445e-06	1.02809E-05	12
55	AKAP7_1	0.0000000393	3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 1.615375160694009e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 5.1570472200670454e-05 / 2.408755304649635e77705	1.765676819518555e-07 / 3.972296959609109e-08 / 3.2695301895520668e-06 / 1.5934388217060153e-05 / 3.721417159936691e-06 / 5.5785045280072256e-06 / 4.163536679627491e-06 / 5.719017833567702e-06 / 1.026744929609048e05 2.8764328668118886e-05 / 2.5301330015839306e-05	0.000155783	12
56	PCMTD2_1	0.0000000068	0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 3.54688199707126e-05 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 2.0071481202007584e-05 / 0.0006813940301036226 / 6.979794879972793e-06 / 0.0005120 167 905	5.861015607960784e-07 / 3.59230415078595e-07 / 6.529460316458851e-08 / 3.4690122473485e-07 / 8.012676260040657e-08 / 1.8059093721170035e-06 / 8.298018416641704e-07 / 9.470642017366756e-05 / 1.948928228321219e-06 / 2.35716 2.8538696820324185e-07 / 6.729556671438922e-06	0.000295734	12
57	ANXA11_1	0.0000005151	2.408755304649635e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 0.004410274724633273 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 0.0019333915490623197 / 4.559947799797 e-05	3.3435882766015197e-08 / 1.9719084534841054e-07 / 7.15064607927488e-08 / 6.417376094706333e-07 / 4.257425478509546e-06 / 1.5694978207696109e-06 / 3.888433936368708e-06 / 5.0965829347694e-07 / 3.057977557175645992-822e 3.6558508721641653e-06 / 2.5076660883555645e-06	0.000545266	12
58	CYP4F22_1	0.0000027180	1.887107728600381e-05 / 0.0001432193232982916 / 0.0003242200414121999 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0010434554869778357 / 0.002087197919276702 / 0.0004963923899259765 / 0.0002441254991542676 / 0.006227948945630897 / 0.00011484315511043709 / 0.00021988598	1.855878357665062e-07 / 4.5205001853266315e-06 / 1.6230646465299277e-07 / 1.9937810791618053e-06 / 2.459173869598607e-06 / 1.418028686271357e-06 / 3.0798872921235664e-06 / 1.4638448696185004e-05 / 4.174632323174143e-06188 8.13226356593833e-06 / 4.0324998931408915e-06	0.000931617	12
59	FAH_1	0.0000000544	9.971939174478468e-05 / 0.0014783442733670397 / 2.051237402337122e-05 / 1.1263759452799203e-06 / 1.7999540459370774e-05 / 0.005398390884784092 / 0.0002944288613709527 / 0.0026702661426604127 / 0.0028963504457353837 / 0.0008619933402586445	1.0046436835312793e-07 / 3.154681248422513e-08 / 5.394104603263994e-07 / 2.7366646890842144e-07 / 5.480720006502052e-08 / 1.6335104962830753e-06 / 1.8420227314596207e-06 / 7.083329258820255e-06 / 2.102391157291273e0606 1.745e 0.00019992317018209673 / 1.9765391249129614e-06	0.001397921	12
60	PRSS35_1	0.0000001503	3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.408755304649635e-05906 0.011066537502725836 / 0.017443989828652796	2.153587369784463e-08 / 1.0035560526801471e-07 / 1.5112245406129175e-07 / 8.734069561342572e-09 / 6.456193736055655e-07 / 1.1915844331577668e-07 / 1.2496790707220447e-06 / 5.187593428631375e-06 / 7.677479865946060 2.4926729322946157e-05 / 6.095320536599329e-05	0.002384904	12
61	ARID2_1	0.0000000008	3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 1.3062838211579366e-05 / 2.7109747094287326e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793 3.54688199707126e-05	1.4085604923353669e-09 / 2.1559634977578997e-08 / 3.073451224470281e-08 / 6.67627891847618e-07 / 9.45287179820993e-07 / 1.6026605078229915e-06 / 2.8723110644674783e-07 / 6.593293352572093e-08 / 1.76044274336364e-06 / 4.083275206575873e-06	1.52054E-05	11
62	GBE1_2	0.0000000002	1.0829140297466289e-09 / 1.1605014260398891e-06 / 2.140496501618477e-08 / 2.4103457859893014e-05 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 3.539399887995572e-05 / 4.926323640851737e-05 / 4.864296167507390706 4.1398213999064624e-06	6.14215099741482e-11 / 8.633691649398072e-08 / 3.1558675335691306e-07 / 6.649001393280087e-07 / 1.5766900825696111e-06 / 4.000342337039938e-06 / 2.5158332022026807e-06 / 1.3914120255170465e-05 / 3.7817976979062494e944 / 1.4262192253107675e-06	1.63761E-05	11
63	FEZF1_2	0.0000000048	2.140496501618477e-08 / 1.0829140297466289e-09 / 1.5415033312027603e-05 / 0.0006617980305097352 / 3.934765724180659e-07 / 4.864296167501907e-07 / 3.539399887995572e-05 / 7.220251902586713e-08 / 1.1605014260398891e14006 05	3.290701334443236e-08 / 5.517282972397794e-07 / 2.461670483939178e-07 / 3.7377331388541626e-05 / 5.142883274641414e-06 / 4.043272115285976e-06 / 2.938617309558263e-05 / 4.8239179614945364e-05 / 7.309372974198873e-06 / 1.0228531 2.3639654167207866e-05	6.72904E-05	11
64	ACACB_2	0.0000000003	2.135362618124217e-07 / 2.2402150648537843e-08 / 3.983245164121986e-08 / 4.136645421698625e-06 / 3.025796797872868e-08 / 0.0005588402339511055 / 8.584401402568793e-06 / 1.471749614726362e-06 / 0.0003892038851689398 / 3.89870447058717e	1.3484124764189522e-08 / 4.706709396786997e-07 / 9.271074896090571e-07 / 5.302698252478667e-06 / 2.0500342574990374e-06 / 1.551726788306523e-06 / 1.781550905952925e-05 / 7.047194494372442e-06 / 1.9709880947249853e-0627 1.1244039336708898e-05	8.83571E-05	11
65	CUX2_1	0.0000000906	0.0001432193232982916 / 1.887107728600381e-05 / 0.0003935478447180597 / 0.00033206653362091303 / 0.00021988598115354305 / 0.0001432193232982916 / 0.0007228851823325908 / 0.00036719870368562404 / 0.00011484315511043709 / 0.00011602560329098725 / 0.0004963923899259765	1.1673991664313873e-07 / 1.284325373822431e-07 / 1.6698077738985942e-06 / 6.902441910511023e-07 / 3.4215164228215663e-07 / 3.007835341834974e-06 / 1.919682119213592e-06 / 1.5381709053459223e-06 / 3.6946271417190457e 6.529025230777642e-06	0.000278923	11
66	H2AFY2_1	0.0000000422	0.0008581803853921776 / 1.1263759452799203e-06 / 2.051237402337122e-05 / 0.0031060111248571412 / 0.0005345324666238675 / 0.0001395680222164631 / 4.369070707050029e-05 / 9.971939174478468e-05 / 0.0003301911422383287 / 0.006072266622156599 / 0.00527944288613	5.135300319990053e-08 / 7.661142091219907e-10 / 7.618409522067726e-07 / 1.0083404706814497e-06 / 8.282189290342112e-07 / 1.147296721987914e-06 / 5.029041750177964e-07 / 2.8221672702900553e-06 / 6.87678977620963866e-06 / 1.681720206 1.5631172248405328e-05	0.001045475	11
67	SCNN1G_1	0.0000000555	3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 9.224071980226081e-07 / 9.206396477	1.613539402686862e-07 / 3.7316428195760516e-08 / 6.371651336534961e-07 / 1.237673510094506e-06 / 6.701672901978117e-05 / 1.972791863813969e-06 / 1.1012098448593559e-06 / 1.967576698919758e-06 / 4.9444208073732495817 3.1007051507707384e-05	0.001646658	11
68	MICAL2_1	0.0000002288	0.00049387566368266 / 8.019236578134864e-05 / 0.004971246918927329 / 0.004078510310946084 / 0.0004290110230937398 / 0.00043106377145357623 / 0.0006315592529035093 / 0.001914379403049941 / 0.0034656404808317003 / 0.0025176594807100345 / 0.00031707617750638764	2.1762204790117787e-09 / 3.2272833090138044e-07 / 7.827762172740352e-08 / 6.06643046842526e-08 / 1.3129367317358875e-07 / 4.830225730426315e-07 / 3.928902637745179e-07 / 3.9101702420209316e-06 / 9.84639797132252e-07 / 6.086407 2.1279294679682064e-06	0.001757292	11
69	SWT1_2	0.0000000170	2.9659818641279015e-06 / 0.00029176699231122706 / 1.5046470240543167e-06 / 0.004644223206500837 / 0.010900569633432996 / 2.7522055206568103e-06 / 0.00013583448483780612 / 0.004741348922243877 / 0.0003486124797281799 / 7.371030323660905e-9559	4.9187331773462e-08 / 2.5012881769902937e-08 / 6.268977803019969e-07 / 1.3528096310298506e-06 / 2.783451231831402e-06 / 2.565078990567409e-07 / 8.86664377274927e-07 / 5.964528017547677e-07 / 6.174004769239488e-07 / 1.0484586327302643e-05	0.001938646	11
70	PDE6B_1	0.0000013889	1.228676574562544e-05 / 0.0011323441860117745 / 8.807499017205126e-05 / 0.002107325343692074 / 0.0014854545690578267 / 0.019751746709410014 / 0.004410274724633273 / 0.005133998810813905 / 0.0020170234515396526 / 0.004410274724633273 / 0.0016232581034909483	5.065661868983875e-07 / 7.17995131525044e-07 / 4.053723016913819e-06 / 8.937583768343871e-07 / 1.1790960971280032e-06 / 4.154079216411671e-06 / 1.726041894379202e-05 / 1.0279309246897823e-05 / 0.0003143462985658605331 05	0.003833824	11
71	FUT11_4	0.0000000000	6.74235053631547e-08 / 4.771768758103407e-07 / 3.1959674906838326e-06 / 1.3575216074689785e-06 / 1.8241579597627434e-05 / 8.479913437625553e-06 / 8.284064752711457e-06 / 0.00018644210000651158 / 5.006828327534464e-05 / 8.236105250	2.4685536420123714e-08 / 4.05022735179046e-08 / 8.733965575196973e-08 / 1.3604574320151334e-07 / 8.805480517015095e-07 / 2.385334687979164e-07 / 4.9124234903367736e-06 / 9.92600195563702e-06 / 3.057977557175645e-06 / 1.118638657	2.8485E-05	10
72	CRMP1_2	0.0000000000	2.0535846739106096e-05 / 1.3401582342156554e-08 / 2.225580423517811e-06 / 1.3942380334535833e-06 / 0.00024560379848655926 / 4.659755401849588e-08 / 2.1627385395830295e-05 / 3.633081984870721e-07 / 3.4192931304829014e-068549787939	7.620811819896486e-06 / 4.382658462880079e-06 / 1.3863143636682347e-05 / 1.3319999198783528e-06 / 1.2152438530817433e-05 / 4.382658462880079e-06 / 8.241971999095359e-06 / 9.923377128421226e-06 / 6.249002717536056e-06 / 5.602505	9.83169E-05	10
73	ATP2B3_2	0.0000000043	0.0003163773097135214 / 7.172518710454511e-06 / 7.245191987655973e-05 / 8.741819060152168e-05 / 5.359794419137135e-05 / 4.430782193013355e-05 / 0.00023847763377654726 / 4.824032561244295e-06 / 4.5251992585881006e-07 / 0.00049496597238	2.4865375915662647e-06 / 1.5062494177669247e-06 / 1.688540465706646e-06 / 1.6196306143315863e-06 / 2.748486185526218e-07 / 2.086193436943505e-05 / 2.6861282329371614e-06 / 5.547613575367754e-06 / 3.303970125073177e-05 / 15238	0.000132005	10
74	KLHL23_2	0.0000000192	6.893999398193879e-07 / 6.419532166056714e-06 / 2.702881264505673e-05 / 6.21390552863653e-07 / 0.0017884623559603927 / 1.6974372024295342e-05 / 0.001013875347197311 / 7.396819433180742e-05 / 0.0005052900676961513 / 7.73108993084	4.968239365259682e-09 / 1.7135370925414656e-07 / 2.932867120091765e-07 / 3.3425571794650135e-07 / 3.0548311202804935e-06 / 3.451257716664588e-06 / 2.1699721245824695e-06 / 4.163536679627491e-06 / 2.920396755301379e657	0.000344106	10
75	PNMAL1_1	0.0000000001	9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 8.058554843717415e-06 / 2.408755304649635e-05 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 3.54688199707126e-05 / 0.003763661611010697 / 2.00714812020084	2.398130659400807e-08 / 3.3728825978612466e-08 / 2.556768800894887e-07 / 1.098753545263955e-07 / 8.352881705441376e-07 / 4.562304305269522e-07 / 1.08096832891062e-06 / 1.1362044976111473e-06 / 3.965156059753076e-06 / 2.5325448	0.000390179	10
76	DPP9_1	0.0000000903	0.0001432193232982916 / 0.009103599585178113 / 0.001710012299865077 / 0.00011602560329098725 / 0.0004963923899259765 / 0.0002441254991542676 / 1.887107728600381e-05 / 0.00021988598115354305 / 0.00033206653362091303 / 0.00011484315511043709	2.8179456082348394e-09 / 2.727075953865357e-06 / 1.168813758935927e-06 / 3.371222633783479e-08 / 4.426276839356633e-07 / 7.736320976296901e-08 / 1.0399111877082387e-07 / 5.1926198984756595e-08 / 2.443030575808895e08	0.001249904	10
77	GPC2_1	0.0000011913	0.00038318838044808375 / 0.0005893191501630695 / 0.00015165886425239433 / 0.0001877376372184388 / 7.79155859315203e-05 / 3.4006794328894204e-05 / 9.771266164691155e-05 / 0.0021345675385303783 / 0.009896861713608592 / 0.00046672125625950257	5.8322357175018814e-08 / 3.819394841783607e-06 / 4.185755315703245e-06 / 8.9047725673033e-06 / 1.688540465706646e-06 / 1.3977429686239098e-06 / 7.632716224230066e-06 / 2.3986226430486996e-06 / 8.321983027984269e0505	0.001401969	10
78	RBM27_1	0.0000328921	0.00019056149396649567 / 1.0762691116666793e-05 / 0.00016655530309410099 / 0.00014532888285824017 / 0.008666672397448167 / 0.0011926586521531122 / 8.547883129077166e-06 / 0.0005615344938163923 / 0.0009516879673421394 / 0.008666672397448167	3.272103105129996e-05 / 6.146543343371357e-05 / 3.6952686083686934e-05 / 1.4957676302550525e-05 / 0.00044169721387816736 / 0.0002538625473566664 / 6.352688846998858e-05 / 0.00045432042455129443 / 0.0011408393624126037 / 4.513400088366357e05	0.002056098	10
79	HOXD13_1	0.0000000916	2.7109747094287326e-07 / 3.2501044823812903e-07 / 3.1219185299958266e-05 / 0.0027465190930067913 / 0.017443989828652796 / 0.016412811603890378 / 9.224071980226081e-07 / 0.0006813940301036226 / 5.2109649171464235e-06 / 9.289397717877934e06	1.1132672619587453e-06 / 2.168405947503928e-06 / 8.632653046332761e-07 / 2.661765393750704e-07 / 2.9706339258865287e-05 / 9.772801528529325e-07 / 6.119157345497534e-06 / 4.403524887759186e-05 / 3.9616874289254276e05	0.003733195	10
80	TFCP2_1	0.0000155106	0.0032558342640986913 / 0.003164163749771866 / 0.007834759439000943 / 0.0006574116836031526 / 0.0004120327968848806 / 0.002547330192150467 / 0.023671720746870278 / 0.01008298563196674 / 0.003825348546364798 / 0.012865293420775923	1.7408199559491215e-08 / 3.662770588769913e-08 / 2.4230602059049713e-09 / 7.057607420139844e-09 / 5.864919427085214e-09 / 4.067269852743229e-09 / 1.2958775867702838e-07 / 2.4061415002001486e-07 / 1.04445857509862e-08 / 8.40682633	0.006831688	10
81	MLC1_2	0.0000000000	2.3317798357459768e-08 / 3.950726068803937e-05 / 7.200240759113992e-08 / 6.485065795284483e-06 / 2.72061163246224e-07 / 1.0914465968113564e-09 / 8.785255275890593e-07 / 2.260908840956264e-06 / 3.4091273206128115e-06	3.821355197181773e-10 / 4.815234643922553e-08 / 4.880618111292151e-07 / 6.535686301472137e-07 / 5.01553847742357e-09 / 9.071527094231567e-07 / 1.561363617000177e-06 / 3.5739771593065375e-08 / 6.799019141310347e-07	5.87882E-06	9
82	NUDT10_1	0.0000000252	5.2109649171464235e-06 / 2.0071481202007584e-05 / 1.3062838211579366e-05 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 6.979794879972793e-06 / 4.559947241482223e05	8.543772901530404e-08 / 3.0560088249163646e-06 / 3.4630204183867344e-06 / 1.75703491771623e-06 / 8.596645616376963e-06 / 6.6659679642121145e-06 / 6.998717296179836e-06 / 6.1225414982440546e-06 / 6.176627272024636e-05	1.57573E-05	9
83	ABHD6_5	0.0000000011	3.358358494818591e-05 / 2.9134927252228483e-07 / 2.9938150702443185e-06 / 2.052332708446901e-06 / 1.4490238008299036e-06 / 3.2017228485917034e-06 / 7.134949223903302e-05 / 9.16995079558899e-05 / 3.381829650307869e05	1.889438601616299e-06 / 1.2766781385500044e-06 / 2.363524198350829e-06 / 3.917011825001329e-06 / 7.303755032082717e-06 / 1.3315374780889495e-05 / 2.4860974232140882e-05 / 1.6960856788042183e-05 / 1.807142776332772e05	2.67155E-05	9
84	NDST4_2	0.0000000040	2.668064610627935e-06 / 6.6526771052306895e-06 / 1.1230314579614556e-05 / 1.8473033200489925e-05 / 6.627915836434039e-07 / 8.256090054064686e-05 / 1.116884259988551e-05 / 5.25757451328789e-05 / 9.075192641901149e-05	9.235058235332018e-08 / 3.739290293217579e-07 / 8.778520319265194e-07 / 4.805213523603749e-07 / 9.024033737327827e-06 / 1.2463662086892492e-06 / 2.593919669520066e-06 / 1.5869215394518834e-05 / 6.9327764685965786e-06	3.07494E-05	9
85	POU3F2_5	0.0000000000	7.323883195296019e-07 / 5.815521557860219e-06 / 1.9482696423142906e-05 / 0.0007454381092335746 / 1.161047392436168e-05 / 1.810779009958944e-06 / 4.647086083767663e-06 / 1.4526839867076841e-05 / 3.820854417705018e-05	4.118783678942697e-07 / 1.9018218973456198e-06 / 5.1834489629063885e-06 / 0.00016912370949213852 / 1.1280051635983909e-05 / 3.251853365907979e-06 / 6.769433778371573e-06 / 2.785132091011529e-05 / 7.035159184655411e-05	9.35858E-05	9
86	RND2_1	0.0000002063	3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 0.0006200425273220967 / 0.0019333915490623197	4.692355741850912e-08 / 3.057428987575251e-08 / 1.287838376941801e-06 / 6.249875151319963e-07 / 2.5823199743834396e-06 / 2.0615635366014647e-06 / 1.0191814256901842e-06 / 1.8943189562108068e-06 / 2.0339342639032117e05	0.000325095	9
87	TEKT2_1	0.0000012269	3.2501044823812903e-07 / 0.00299921656722761 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 0.0019333915490623197	2.626807545548127e-07 / 8.972858217500653e-07 / 8.188038459526457e-05 / 1.2353713533928581e-05 / 4.657480324879461e-05 / 6.734781530483014e-06 / 3.917368514292802e-05 / 4.398198496660895e-05 / 3.85813042649088e-05	0.000552853	9
88	RCOR1_1	0.0000002629	0.0035374364838401885 / 0.0005794708000429308 / 0.004598611207763406 / 0.00027838639004009185 / 0.00254170936910902 / 0.0007730790428095843 / 0.0008116048904747243 / 0.00028760490535839194 / 0.0006209741142612609	2.12095972377237e-08 / 5.371804546576567e-07 / 1.3631627975922064e-06 / 1.3930567108132102e-05 / 7.320109762709196e-06 / 3.5012227758823163e-06 / 9.972925901562962e-06 / 5.848283608879877e-06 / 1.9939940203933426e-05	0.001558764	9
89	SH3GLB1_1	0.0000001142	1.1263759452799203e-06 / 0.0002944288613709527 / 1.7999540459370774e-05 / 0.009181416163184238 / 0.0001249119186090808 / 0.001133267650419163 / 0.0026702661426604127 / 0.005398390884784092 / 0.00014547367344876742	5.021137237572428e-08 / 1.412114735889678e-07 / 2.6082574074268862e-06 / 2.1694530129992346e-06 / 2.622668544008386e-06 / 1.3863143636682347e-05 / 2.2950455177001124e-05 / 8.882430105407664e-06 / 8.761908558227523e-06	0.002107476	9
90	ZCCHC5_1	0.0000003387	0.0002944288613709527 / 0.004641723683002966 / 0.00036105139567184824 / 0.0036790499750236597 / 0.0005345324666238675 / 0.0021653473543332357 / 0.0067509647795811235 / 0.0033178709219427965 / 0.0001395680222164631	2.1634030409586368e-05 / 1.0447439952129488e-05 / 4.841492876651217e-06 / 8.425020418700623e-06 / 1.7550566576642783e-06 / 1.829374010437789e-05 / 0.00016237480333105512 / 2.4267895369009183e-05 / 1.021655106614923e-05	0.002431615	9
91	EVI2B_1	0.0000000810	0.0005654433700885616 / 0.0021345675385303783 / 0.0010514734188248587 / 0.01706732677471782 / 0.00016882475928990226 / 0.0017046060667733898 / 1.7173658335771082e-06 / 0.0010760707198761224 / 0.01365229997365103	4.967070750533046e-07 / 9.339254057047784e-06 / 2.37004080182631e-05 / 1.7573172310813478e-05 / 4.067330085914587e-07 / 1.0577974069325492e-06 / 9.173510310512699e-06 / 1.887257789753108e-05 / 6.115093766942535e-05	0.004158037	9
92	EPC1_2	0.0000000072	0.0034390541604176214 / 0.0002448208689788285 / 0.01617199881991826 / 0.02211371791626479 / 0.0025035638269418226 / 0.01851025775546256 / 0.006305703578524486 / 0.00515664879236201 / 0.009067920198647179	5.695617165978249e-07 / 1.1672960349256724e-07 / 2.840596912722915e-06 / 6.081404109618168e-06 / 2.4211525355218317e-06 / 1.1016073014221325e-05 / 1.0934695006353887e-05 / 4.4117963688512546e-05 / 2.106616906903645e-05	0.009279298	9
93	VAX1_2	0.0000000005	1.3401582342156554e-08 / 4.659755401849588e-08 / 4.835640776889601e-06 / 7.359704703027111e-07 / 1.096889887353167e-06 / 1.3942380334535833e-06 / 5.207246052888057e-07 / 3.4192931304829014e-06	7.755118664932962e-08 / 9.171116579440387e-08 / 1.1013084399854174e-05 / 4.524910966526263e-06 / 1.529385415217493e-06 / 1.427223677524831e-05 / 1.4066320814267013e-05 / 2.2774582231147903e-05	1.50784E-06	8
94	DLG2_3	0.0000000002	7.813308929582946e-09 / 1.6547061876174137e-09 / 1.3841014381780992e-08 / 3.911794473620475e-08 / 3.925563562928499e-06 / 1.0025262671531361e-05 / 1.4592559377242048e-06 / 7.203525855071736e-08	5.333355940483967e-07 / 2.493514693804668e-05 / 1.3553742801395556e-05 / 2.784723823441103e-05 / 0.00031844709703193725 / 3.540970687955017e-05 / 4.292537092544752e-05 / 4.4176636548796324e-05	1.94307E-06	8
95	PPP1R1A_2	0.0000000058	6.21390552863653e-07 / 6.893999398193879e-07 / 7.492219023207615e-07 / 2.702881264505673e-05 / 3.680752556412065e-06 / 1.6060512405884523e-05 / 7.73108993011784e-06 / 6.419532166056714e-06	2.1597799174876656e-06 / 1.9305294911280603e-06 / 5.352949078223872e-06 / 6.799175330608916e-06 / 8.452688032747793e-06 / 1.5945569790774137e-05 / 3.22477346098806e-05 / 2.984896137178954e-05	7.87259E-06	8
96	EFNB1_1	0.0000000276	2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 4.0242980256377906e-05 / 3.2501044823812903e-07 / 0.0004073113752386311 / 5.2109649171464235e-06 / 4.559947241482223e-05	2.1957511801277782e-07 / 4.889428996554765e-08 / 2.1248474074975664e-07 / 1.7135370925414656e-07 / 3.884450294793579e-06 / 5.591633483860606e-06 / 1.8857958946421756e-06 / 2.8107942340015973e-05	6.33579E-05	8
97	POU3F1_2	0.0000000002	1.0829140297466289e-09 / 2.140496501618477e-08 / 0.0006617980305097352 / 3.539399887995572e-05 / 1.1605014260398891e-06 / 4.1398213999064624e-06 / 4.864296167501907e-07 / 1.3483681400210042e-06	6.030358521257982e-09 / 1.7387409176294374e-08 / 5.254390767028075e-06 / 2.543218750177778e-06 / 1.6396573544351217e-06 / 8.529464444824402e-07 / 6.695092024209846e-06 / 8.770352824154869e-06	8.80437E-05	8
98	JPH1_2	0.0000000087	5.556780192800504e-08 / 2.0874526624748995e-06 / 0.0012644399858917665 / 4.607960729596523e-06 / 2.1738520362230936e-05 / 1.6503521660931074e-06 / 2.1738520362230936e-05 / 0.00015574282021503215	3.4277179006258406e-08 / 1.490529071824182e-08 / 3.286947652963165e-05 / 8.194195146930721e-06 / 2.1888678883833245e-05 / 2.6787516426543844e-06 / 1.2909385190385643e-05 / 1.5296407537085686e-05	0.000184008	8
99	LGALS3_5	0.0000000000	0.0003565042040229888 / 9.438944028750308e-06 / 9.04485841302387e-07 / 1.6632151970584391e-06 / 3.410158051548764e-05 / 0.0003318801877935931 / 0.0012804486516771864 / 0.00021733046754869307	6.677920897376901e-06 / 2.6764509283677262e-06 / 1.8682268381796687e-06 / 7.156112560189961e-06 / 5.102936564089435e-05 / 1.756292794705785e-05 / 9.025855388190028e-05 / 1.637569955003e-05	0.000279034	8
100	LRRC4B_1	0.0000002709	1.887107728600381e-05 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00011602560329098725 / 0.00021988598115354305 / 0.0007228851823325908 / 0.002087197919276702 / 0.0004963923899259765	5.474742848216316e-08 / 7.540000372679234e-08 / 2.4324836459725464e-07 / 1.1863961735006869e-06 / 1.582805196129757e-06 / 3.4634781029298443e-06 / 3.0574198226347985e-06 / 7.803003903662519e-07	0.000543533	8
101	ARHGAP19_1	0.0000004900	1.1263759452799203e-06 / 0.0002944288613709527 / 2.051237402337122e-05 / 0.00014547367344876742 / 0.0003301911422383287 / 0.0001395680222164631 / 0.0026702661426604127 / 0.006072266622156599	8.088262923201297e-10 / 5.32512126526287e-09 / 8.298236021731966e-08 / 3.5084952233067013e-07 / 2.3265577637109093e-06 / 1.1001720936904985e-06 / 3.6392711556668255e-06 / 1.2562017250662189e-06	0.001209229	8
102	MYL9_1	0.0000000778	9.224071980226081e-07 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 3.2501044823812903e-07	2.459173869598607e-06 / 3.652101302901246e-06 / 1.2972527217084128e-05 / 8.597378090854104e-06 / 5.7833188092788925e-06 / 1.4022276300344631e-05 / 2.145854408813797e-06	4.89895E-06	7
103	TMEM170B_1	0.0000002606	9.289397717877934e-06 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 4.559947241482223e-05 / 2.408755304649635e-05 / 5.2109649171464235e-06	1.9697921819906958e-07 / 3.165978824218861e-07 / 2.2816438659720932e-06 / 2.742836199391347e-06 / 6.990510977409468e-05 / 2.9323575212698406e-06 / 8.993575247920803e-05	1.50723E-05	7
104	CSAD_1	0.0000002822	5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 6.979794879972793e-06	6.111203426085803e-07 / 2.171879517260808e-06 / 5.854820901741727e-07 / 7.835058995288738e-07 / 2.7557290434491165e-06 / 6.817652862377265e-07 / 1.2092985656812561e-05	1.62017E-05	7
105	ASGR1_5	0.0000000000	1.1623489088470996e-07 / 3.721066145469274e-07 / 3.333239304736607e-06 / 2.1608013080506192e-07 / 3.230485829869497e-05 / 8.060189282236343e-06 / 8.676969132083257e-05	7.305647078744524e-09 / 5.144455443656822e-07 / 1.4357703259269896e-06 / 1.2509260043210937e-08 / 5.934720152286974e-06 / 2.2212849303091722e-05 / 1.856219255522198e-05	1.87389E-05	7
106	KIAA1958_1	0.0000014113	9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.0071481202007584e-05 / 0.00029640089162746337 / 1.3062838211579366e-05 / 2.408755304649635e-05	1.7837147826607992e-06 / 6.377999497501375e-07 / 6.986597395696305e-07 / 2.0980658004722796e-06 / 1.9921322770288805e-06 / 1.773331235256366e-05 / 5.3250557763788615e-06	5.20228E-05	7
107	NPW_2	0.0000000041	3.24920563754477e-05 / 1.6676618048371524e-06 / 3.349324237754571e-06 / 0.00026033133118006545 / 2.8198901661861037e-07 / 1.3377106429420062e-05 / 0.00015487870247863725	1.1216334102038042e-05 / 3.795870398901593e-05 / 2.789700527592356e-05 / 2.4370350557859375e-05 / 2.383281576252229e-06 / 1.739637519533283e-05 / 4.995051896804675e-05	6.66255E-05	7
108	CAP1_1	0.0000001084	3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 5.1570472200670454e-05 / 0.0006813940301036226 / 1.615375160694009e-05	2.3269670797546372e-09 / 2.178989287248064e-07 / 1.5690808649462252e-07 / 2.2812382420261574e-07 / 5.003267757352306e-07 / 5.854077230406485e-06 / 3.5713716118086355e-06	0.000111963	7
109	SIAH3_1	0.0000003288	2.7109747094287326e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 3.2501044823812903e-07 / 1.615375160694009e-05 / 0.0019333915490623197	6.049342679130285e-07 / 8.815712638887937e-06 / 4.740549194395327e-06 / 9.480468782335477e-06 / 1.5820053502878103e-05 / 6.463404069739772e-06 / 1.6126637325555423e-05	0.000283492	7
110	PALM3_1	0.0000000299	1.1263759452799203e-06 / 0.00014547367344876742 / 0.0002944288613709527 / 6.267778266652492e-05 / 0.00036105139567184824 / 4.369070707050029e-05 / 0.0012393227037226365	1.61127559567575e-08 / 5.017834401276047e-07 / 3.661929862620404e-06 / 1.2173443563611742e-05 / 1.1966193354414176e-05 / 2.4195118600922182e-05 / 1.7243254719929916e-05	0.000306824	7
111	STMN3_1	0.0000000026	7.246316173948605e-05 / 3.547654313435299e-05 / 0.0009373528710364089 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0003279301515605841	7.322406775875832e-06 / 8.942892958849265e-06 / 1.807142776332772e-05 / 2.509219654843992e-05 / 1.8505484636417077e-05 / 3.37731892462157e-05 / 9.285668025091915e-06	0.000473893	7
112	TMEM81_1	0.0000008765	5.273896379563962e-05 / 6.356656086987109e-05 / 0.00043134694416039135 / 0.00013546030217733798 / 0.0004059772887267331 / 0.0023391751758116753 / 0.00032373731095170963	1.0787679920477812e-07 / 2.5789707372412023e-07 / 2.2840059569727543e-06 / 3.5876629179259e-06 / 1.224552952677817e-05 / 1.3699807790719473e-05 / 0.00010021610177229421	0.000536	7
113	SPATA6L_2	0.0000000000	6.561438181488045e-08 / 0.0039060792371246288 / 1.2713340125393577e-06 / 4.9709559427158936e-05 / 2.9984630262222775e-05 / 2.5044323053359897e-05 / 0.0003189222745634422	1.1928730580085498e-07 / 1.6308994378745635e-05 / 7.252465307108788e-07 / 4.675129100784084e-05 / 2.4918595616148034e-05 / 1.2527391630040111e-05 / 0.00035139543234848433	0.000618725	7
114	CSRP2BP_5	0.0000000001	0.0010693215114176687 / 0.0005366621924321155 / 5.114637961482107e-05 / 0.001965268902490897 / 0.0006502221049801445 / 1.6105294963590637e-05 / 0.0010730574005743563	3.1276785123692046e-07 / 9.71112422824034e-07 / 6.485117187559721e-06 / 9.024033737327827e-06 / 2.832326930093088e-06 / 4.687104252350739e-07 / 1.9659786069911358e-05	0.000765969	7
115	MAP2K6_1	0.0000003962	0.00049387566368266 / 0.001914379403049941 / 0.0025176594807100345 / 0.0006315592529035093 / 0.0034656404808317003 / 0.00043106377145357623 / 0.004971246918927329	1.1930754029013138e-06 / 8.239304675009157e-06 / 9.456559403963851e-07 / 1.224552952677817e-05 / 1.1431401687645685e-05 / 4.3734040668837504e-05 / 2.2586038013431965e-05	0.002060775	7
116	HOXB13_1	0.0000005163	3.2501044823812903e-07 / 0.011066537502725836 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 0.017443989828652796 / 1.615375160694009e-05	2.2857725793381497e-08 / 6.58231193542836e-07 / 9.335221622816497e-07 / 5.9574734192841e-07 / 9.009609250490209e-07 / 6.752637204404786e-06 / 6.717516905544411e-06	0.004079613	7
117	RBM12B_1	0.0000027010	0.04720120118838744 / 0.01326934306028551 / 0.016928162681653376 / 0.031078733529297287 / 0.002048221708938053 / 0.0034110277620841853 / 0.0010661050941684071	2.1680661197087e-06 / 2.9189015908569146e-07 / 1.1699094105987198e-06 / 7.252465307108788e-07 / 7.978099824844419e-07 / 9.884000914674844e-06 / 2.094766018419809e-07	0.016428971	7
118	ADRB3_1	0.0000000110	3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 9.224071980226081e-07	4.241171654391019e-07 / 1.460759694934436e-06 / 1.0275041110630902e-05 / 2.951788675228993e-05 / 2.7256307870565235e-06 / 1.7536333634491446e-06	5.3003E-06	6
119	LUC7L_5	0.0000000000	4.893976636572636e-08 / 4.301553480101108e-06 / 1.9454781373606418e-07 / 2.401972521996653e-06 / 2.7416809858149543e-05 / 2.126445195983224e-06	9.243344747900569e-10 / 5.575865427598105e-07 / 7.332853758502689e-07 / 1.804034226196658e-06 / 3.3436666464536245e-05 / 5.494452455047808e-06	6.08171E-06	6
120	ITM2A_1	0.0000000846	2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 4.0242980256377906e-05	9.57143021581257e-08 / 2.3530982511650296e-08 / 9.277238538824435e-08 / 9.772375417317643e-08 / 7.542510909686565e-07 / 5.344419818471506e-07	8.99204E-06	6
121	ICAM4_1	0.0000001503	3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 3.1219185299958266e-05 / 2.7109747094287326e-07	6.095674277276536e-08 / 1.9332727891019487e-07 / 1.5381709053459223e-06 / 2.6680204178603233e-06 / 3.8772692803359075e-06 / 2.7997676176494448e-05	1.03498E-05	6
122	HMCN1_1	0.0000002057	9.224071980226081e-07 / 6.979794879972793e-06 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 3.54688199707126e-05 / 2.7109747094287326e-07	2.325888657256971e-08 / 7.057956530849985e-08 / 4.408357829435433e-07 / 3.236174072045171e-07 / 2.3836720647269927e-06 / 1.2257808319403609e-05	1.06731E-05	6
123	ZNF397_4	0.0000000000	1.1490697075516314e-07 / 5.267608369882088e-05 / 2.6997110563148354e-05 / 1.1548564870533097e-06 / 2.0333256661723552e-08 / 5.997442187105882e-06	1.209273134002773e-07 / 2.356993671060887e-07 / 1.889438601616299e-06 / 4.5197938838389625e-07 / 1.0616232919691243e-07 / 1.1196923674745125e-06	1.44935E-05	6
124	DRAP1_1	0.0000000328	2.408755304649635e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 5.1570472200670454e-05	1.8161954541326127e-08 / 2.3467711706414707e-08 / 7.39840605537318e-08 / 9.681901028699171e-08 / 6.251568155356543e-07 / 7.07965550831983e-07	1.77111E-05	6
125	DTX3L_1	0.0000000920	2.408755304649635e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.1570472200670454e-05	3.2169896739895314e-07 / 6.548683737212715e-07 / 1.9632962963789034e-07 / 8.23683137309925e-07 / 1.3384906301502949e-06 / 3.688500356447034e-06	2.02773E-05	6
126	NUDT11_5	0.0000000000	2.520077460838455e-06 / 0.00019847043212428944 / 9.212731853638905e-06 / 5.327685852957849e-05 / 7.074807022331135e-06 / 5.506319326881712e-06	6.030864046314226e-07 / 5.4148978375789446e-05 / 4.298503068923771e-06 / 4.6387467002391374e-07 / 3.113591613373381e-06 / 2.237597740187554e-06	4.60102E-05	6
127	ADAM19_3	0.0000000000	0.00014925747204187325 / 2.926784989427661e-05 / 3.9436377050004215e-05 / 8.350382499334708e-05 / 9.099838750221392e-06 / 0.00012689846158790022	4.429367557026339e-06 / 3.859292848839367e-07 / 7.371158036631407e-06 / 3.558113101675235e-06 / 1.737907854441337e-05 / 1.0224109644328716e-05	7.29106E-05	6
128	HS3ST4_2	0.0000000267	4.981322036893917e-06 / 2.606975599460185e-05 / 8.565659227788306e-05 / 0.0002754556536102276 / 7.209835341373319e-05 / 3.152964683173717e-05	1.1012098448593559e-06 / 1.1675757440124896e-05 / 1.5407255327564443e-05 / 1.049514284917264e-05 / 1.031858123131195e-05 / 0.0001438654836752122	8.26319E-05	6
129	CRIPAK_4	0.0000000000	0.00015414987039053912 / 0.00011823367623626102 / 0.0009189200604961089 / 0.0007149452063580587 / 0.0006845676304155839 / 0.00041005648424125555	2.245806750816546e-06 / 4.7163754949833893e-07 / 2.309187383213676e-06 / 1.0481115140245655e-05 / 1.5648091897413959e-06 / 2.123855035553147e-06	0.000500145	6
130	OLFM3_1	0.0000002915	1.1263759452799203e-06 / 9.971939174478468e-05 / 2.051237402337122e-05 / 0.0001395680222164631 / 0.0028963504457353837 / 7.924407878618111e-05	2.6837870218219574e-09 / 3.561518617190357e-08 / 1.882754136330223e-07 / 1.470434762035522e-07 / 3.069489887698277e-07 / 4.200340993458125e-06	0.00053942	6
131	LMO2_4	0.0000000000	1.3505056742555753e-05 / 1.1618150079504721e-07 / 0.00013064212236741545 / 4.111357296377365e-06 / 0.0035192650416157674 / 4.781143220313644e-05	2.1639192493163854e-06 / 1.7833831305356847e-07 / 2.620411019163743e-06 / 2.1101434315006795e-06 / 2.7275081013397453e-05 / 1.3040674962690977e-06	0.000619242	6
132	SALL2_1	0.0000003934	1.1263759452799203e-06 / 0.0038265104822853674 / 2.051237402337122e-05 / 0.0002944288613709527 / 0.0008581803853921776 / 0.00014547367344876742	1.6243939304465606e-09 / 9.280889011804578e-07 / 7.466764406748627e-07 / 6.300687009130246e-07 / 1.0493357935620423e-05 / 9.50907155614804e-07	0.000857705	6
133	SLC35F3_1	0.0000002146	0.0008619727380490119 / 0.004410274724633273 / 8.807499017205126e-05 / 0.0007073001228128905 / 1.228676574562544e-05 / 0.002107325343692074	4.661997914978101e-07 / 8.34478701501445e-07 / 8.627333575428783e-07 / 1.0961759232568219e-05 / 1.5605455965805294e-06 / 4.962489165357357e-06	0.001364539	6
134	RHOH_1	0.0000001993	1.887107728600381e-05 / 0.0001432193232982916 / 0.0002441254991542676 / 0.0020865035640383737 / 0.006227948945630897 / 0.00021988598115354305	8.908782275302052e-08 / 1.3002938709565544e-06 / 8.336014361253352e-07 / 1.0527458641807459e-06 / 1.1820153415714242e-05 / 2.4865375915662647e-06	0.001490092	6
135	MED23_1	0.0000009756	0.0007073001228128905 / 0.0011323441860117745 / 0.004410274724633273 / 0.0010325370165401593 / 0.002107325343692074 / 0.0016226906289916678	1.0975653631511024e-07 / 1.045969028083387e-07 / 6.416985820926155e-07 / 1.5558825628623162e-06 / 8.122287757832368e-07 / 1.1607897314120871e-06	0.001835412	6
136	ALS2CR8_2	0.0000000009	0.0006315082871911089 / 0.0005431426189626602 / 0.0021396275484352 / 0.026018702566094058 / 0.001000241728120363 / 0.0003308344387923977	1.2953287867816182e-06 / 3.495208827896601e-06 / 1.6445250431991489e-06 / 2.13746074336515e-05 / 1.4749418379777713e-06 / 1.7906341936525482e-06	0.005110676	6
137	PDS5B_1	0.0000000930	0.009896861713608592 / 0.020827775351599746 / 0.0012471395414138215 / 0.0017014302658606788 / 0.0353590157796084 / 0.0012471395414138215	3.174956286948255e-05 / 2.3820952039675057e-05 / 7.64885082423866e-07 / 5.201073420332339e-07 / 3.138162419750589e-05 / 1.8874782131634276e-06	0.011713227	6
138	POU4F1_1	0.0000343460	0.009505749235636515 / 0.01380503352362386 / 0.006032512595643146 / 0.016514991038692903 / 0.03991486389987273 / 0.023304012767638813	1.736820199971154e-08 / 1.0181132930253954e-06 / 0.00018045749659898887 / 7.716585431260322e-06 / 5.0799933930760124e-06 / 2.2950455177001124e-05	0.018179527	6
139	LINGO1_4	0.0000000000	1.7973910992848286e-09 / 3.2068838263254377e-07 / 5.436354594228244e-06 / 9.44534744977059e-08 / 8.340191540542289e-07	4.250081788501893e-07 / 3.2784019242777824e-06 / 9.246191514674586e-06 / 6.77126904336827e-07 / 1.2203319241697544e-05	1.33746E-06	5
140	EZH2_2	0.0000000004	2.2402150648537843e-08 / 1.471749614726362e-06 / 3.983245164121986e-08 / 8.584401402568793e-06 / 2.135362618124217e-07	7.330469554133431e-08 / 6.45181252176691e-06 / 2.8233957548442e-07 / 1.386977654368529e-06 / 3.4840585402585815e-07	2.06638E-06	5
141	ZNF786_5	0.0000000000	0.00011773904137664178 / 1.3280032513820524e-05 / 9.576463103103271e-05 / 4.4014899917305675e-06 / 8.430577899747024e-06	2.140329000239017e-05 / 7.930355204992489e-07 / 4.145669385412816e-06 / 9.512787508368679e-07 / 2.434604498224823e-06	4.79232E-05	5
142	SLCO5A1_1	0.0000008012	3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.408755304649635e-05 / 9.289397717877934e-06	3.0174324318950897e-07 / 9.418668072896726e-07 / 1.6676348515768935e-05 / 3.957834622626353e-06 / 6.700293161768197e-06	7.02847E-05	5
143	DKK2_1	0.0000006927	9.224071980226081e-07 / 2.7109747094287326e-07 / 3.2501044823812903e-07 / 0.0004073113752386311 / 9.289397717877934e-06	6.460209020485614e-08 / 3.59230415078595e-07 / 1.0312698979503442e-06 / 1.4199406561075603e-05 / 5.457198354391937e-06	8.36239E-05	5
144	ATP11C_1	0.0000001503	2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 0.0004422271229621968 / 5.2109649171464235e-06	1.9332727891019487e-07 / 1.36409072963545e-08 / 3.1896874375468994e-07 / 4.81561728868056e-06 / 8.990145137526255e-07	9.11223E-05	5
145	KMO_1	0.0000001461	1.887107728600381e-05 / 0.0001432193232982916 / 0.0005437871552770366 / 0.00021988598115354305 / 0.0002441254991542676	2.485807963409032e-07 / 1.1240339046572947e-06 / 3.782902556894412e-07 / 4.67845142282578e-06 / 3.603323688705048e-06	0.000233978	5
146	SPOCD1_1	0.0000000083	3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.0019333915490623197 / 1.615375160694009e-05	7.818277659920641e-08 / 5.795083345677293e-07 / 4.4221671271015996e-06 / 9.908657729834685e-06 / 1.2284458405143113e-05	0.000394173	5
147	LMO3_1	0.0000005163	2.0071481202007584e-05 / 9.224071980226081e-07 / 0.00029640089162746337 / 6.979794879972793e-06 / 0.005510243055764825	2.8303059659858582e-08 / 1.2770021336022465e-07 / 1.8886612700849868e-06 / 1.5048748666061165e-06 / 9.979708008853078e-07	0.001166924	5
148	SUCLG2_1	0.0000006277	0.0012538224517635887 / 0.00030020193073310375 / 0.001142443802029975 / 0.0015995521116198169 / 0.0025493281320611745	6.010018117118236e-09 / 1.4873864874902438e-08 / 2.812059954690805e-06 / 4.5297727245223865e-07 / 1.0136268892104269e-06	0.00136907	5
149	CDC42EP3_1	0.0000005053	0.00015668136762185704 / 0.0017937623479293012 / 0.00014067446309259184 / 0.0006379488254521119 / 0.0054623966213403945	4.0545605557306084e-07 / 2.0579987707958014e-06 / 6.648866334116203e-06 / 6.110689397168396e-05 / 5.05967411068452e-06	0.001638293	5
150	VIM_2	0.0000150468	0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 / 0.006523673737606515 / 0.0004302878134597533	3.450494605886152e-11 / 2.904281074975244e-11 / 4.5432513762116924e-07 / 4.7610232918156417e-07 / 3.936782111680953e-06	0.00171452	5
151	KIAA1456_5	0.0000000000	3.392135383479947e-09 / 1.6065108187886577e-09 / 9.157017996950809e-07 / 3.6928231492352363e-07	5.371804546576567e-07 / 8.674274096479547e-08 / 5.026970587223131e-06 / 3.9399829491464125e-06	3.22496E-07	4
152	ATP1A1_1	0.0000003288	2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06	4.379090848715678e-06 / 3.77167172557141e-06 / 3.5551496515817035e-06 / 8.53191167142631e-06	2.12458E-06	4
153	EFHD2_3	0.0000000000	2.621657181978166e-09 / 5.054801258373376e-07 / 9.68006271762989e-06 / 1.8365412363165977e-07	8.572257412643892e-07 / 1.794103459804273e-06 / 9.95075608052033e-06 / 1.2610525065949156e-05	2.59295E-06	4
154	NPY1R_1	0.0000000555	3.2501044823812903e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 9.224071980226081e-07	3.314259306506593e-07 / 3.2811589034439775e-06 / 2.0319189662380453e-05 / 4.769447269863606e-06	2.70198E-06	4
155	PTPN13_1	0.0000002820	2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06	2.6783272230077516e-07 / 1.895295482848707e-08 / 1.8806480924583324e-07 / 9.335221622816497e-07	3.34607E-06	4
156	SOX11_3	0.0000000001	1.2099644991608733e-05 / 2.0089868169610723e-07 / 1.0776466574906309e-07 / 4.755876859816789e-06	7.955105981028123e-06 / 1.0121247355306893e-06 / 3.4448329577362182e-06 / 1.4342875182087443e-05	4.29105E-06	4
157	RAVER2_1	0.0000000192	3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 1.3062838211579366e-05	3.105760909035132e-07 / 7.687495446941115e-07 / 1.1986592733451634e-06 / 9.900405822480467e-06	5.89991E-06	4
158	CD44_3	0.0000000000	7.172707428277077e-07 / 4.481007438950932e-07 / 8.746535299915613e-07 / 2.5220058311922642e-05	1.7230525778249127e-07 / 2.754399275478179e-07 / 5.399255839823898e-06 / 5.404432984233412e-06	6.81502E-06	4
159	WIPI1_1	0.0000000779	3.2501044823812903e-07 / 4.559947241482223e-05 / 9.224071980226081e-07 / 2.408755304649635e-05	2.847754855927293e-07 / 5.356440974504928e-05 / 3.583982029691469e-06 / 9.40961708804259e-06	1.77336E-05	4
160	MEIG1_1	0.0000021159	2.768256422538597e-05 / 9.531965824595176e-05 / 3.738602753166595e-05 / 7.050646137918624e-07	3.8552589093989376e-07 / 5.403268031058945e-06 / 1.875181574291302e-06 / 3.691562617026471e-06	4.02733E-05	4
161	ITGAV_1	0.0000043137	5.198191671140737e-06 / 2.078130544858706e-05 / 8.173042888768766e-05 / 6.124458953230731e-05	2.675335342140057e-08 / 5.91155167762294e-06 / 3.175137319143903e-07 / 1.4088412652065131e-05	4.22386E-05	4
162	WASF1_2	0.0000000139	1.249810740543092e-06 / 4.033558519530211e-05 / 1.5172365718941338e-06 / 0.00016701924649532873	4.465170531049283e-08 / 7.347798043454918e-07 / 3.12571392342915e-07 / 2.1882250573351623e-06	5.25305E-05	4
163	SEPT5_1	0.0000000779	3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.0071481202007584e-05	4.6698972944525575e-06 / 2.50941550434497e-06 / 7.4466622077249586e-06 / 4.094296941956349e-06	8.45295E-05	4
164	ZNF703_4	0.0000000000	2.212311553111884e-06 / 7.684875066256022e-06 / 1.6293260278199978e-05 / 0.0008381727818825804	3.314259306506593e-07 / 7.977471601458215e-07 / 1.8053474935255696e-05 / 2.523320003794371e-06	0.000216091	4
165	RCAN1_1	0.0000004561	2.051237402337122e-05 / 0.0008581803853921776 / 1.1263759452799203e-06 / 0.00014547367344876742	1.151531177459646e-07 / 1.639867245393111e-05 / 1.1127380583214237e-07 / 3.9475777725155106e-07	0.000256323	4
166	MEIS1_1	0.0000004303	0.0001249119186090808 / 0.001757554115983901 / 2.051237402337122e-05 / 0.000326206047495105	2.6783272230077516e-07 / 3.936737849973941e-06 / 1.6694305968259358e-06 / 7.365498385123174e-06	0.000557296	4
167	DOCK9_2	0.0000000000	4.145085061135413e-05 / 3.702123384814164e-05 / 0.0003340879256796464 / 0.001986982649747413	2.7146173079304695e-06 / 2.6989667147770683e-07 / 5.081672826189643e-05 / 3.9279153945945585e-05	0.000599886	4
168	MAP2K1_1	0.0000000599	0.0007934067413946306 / 0.001424661642376461 / 0.0001432193232982916 / 0.0001432193232982916	6.397852510979244e-07 / 1.229050427171932e-05 / 4.600454084913176e-07 / 1.216134119529828e-07	0.000626127	4
169	BAZ2A_1	0.0000087909	0.0006400860846326889 / 0.00019507867134893112 / 0.0005646566395776797 / 0.0011256461353458978	3.4543484518327023e-07 / 2.666805309562172e-06 / 5.506146432831658e-07 / 2.9358775945182435e-06	0.000631367	4
170	TMEM70_2	0.0000000042	0.000803532445292482 / 3.592934798967807e-05 / 2.0485173730412846e-05 / 0.002205124341612829	2.2344846667733606e-07 / 1.07351128025269e-06 / 3.1896874375468994e-07 / 3.0408081748624807e-06	0.000766268	4
171	CSRP3_1	0.0000008027	0.0018449614599039168 / 0.00038686777181974065 / 0.00048368218865146016 / 0.001675382961010776	2.60376611739122e-06 / 2.102391157291273e-06 / 2.004512392075139e-06 / 1.2729780600591483e-06	0.001097724	4
172	MSRB3_1	0.0000003307	2.1638869199653735e-05 / 0.0029815335281472605 / 0.0005737747064104953 / 0.007382285536659921	1.4806435472894142e-06 / 1.0110256424760308e-06 / 3.5361568488813283e-06 / 8.63235449098127e-05	0.002739808	4
173	PTGER2_1	0.0000002152	0.00269524080408226 / 0.007101048391336863 / 0.00668150271306391 / 7.915379277260866e-05	3.584070271555361e-09 / 1.3436997812686243e-07 / 1.3606501871455058e-06 / 1.1858761514818132e-06	0.004139236	4
174	ARHGAP44_2	0.0000005305	0.001389487072786441 / 3.911112061086556e-05 / 0.0072669444150837495 / 0.032560551569980084	1.5851926645157727e-06 / 5.333355940483967e-07 / 4.1196587397566423e-07 / 1.9907111943687763e-05	0.010314024	4
175	TTC7A_2	0.0000431038	0.0034136112166290996 / 0.019663495986739683 / 0.015108389305698126 / 0.023304012767638813	1.9331908145550604e-07 / 2.9725508005745186e-07 / 6.456589638188038e-07 / 1.1620049901469098e-06	0.015372377	4
176	SLC35F1_1	0.0000000393	9.224071980226081e-07 / 3.2501044823812903e-07 / 2.7109747094287326e-07	2.910892954811522e-06 / 2.427468480432927e-06 / 1.497883668566738e-05	5.06172E-07	3
177	KRT25_4	0.0000000910	1.8022657475902624e-06 / 3.876432302949376e-08 / 9.243212121314035e-07	8.698985549478663e-06 / 1.3122203018407308e-05 / 2.3955519604051558e-05	9.21784E-07	3
178	PAX7_1	0.0000004451	3.2501044823812903e-07 / 9.224071980226081e-07 / 5.2109649171464235e-06	2.237597740187554e-06 / 4.6661224912755335e-06 / 6.814494589515358e-05	2.15279E-06	3
179	ENC1_1	0.0000002820	3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06	1.9120440072426562e-07 / 4.6661224912755335e-06 / 2.0866430814653658e-06	2.7424E-06	3
180	ERO1L_3	0.0000000002	4.539445950022412e-06 / 2.5790650047618876e-07 / 3.931265767356836e-06	8.753743400501336e-05 / 2.307172538255043e-06 / 0.0001811706174672882	2.90954E-06	3
181	KANSL2_2	0.0000000036	5.454092964102538e-06 / 2.0483330180932313e-06 / 1.3610927050562742e-06	1.3993846023737915e-07 / 4.67736331535542e-05 / 3.809175259493249e-06	2.95451E-06	3
182	RPN1_3	0.0000000004	8.225833660011401e-07 / 8.696575941061198e-06 / 2.1691780926743226e-07	2.5845817998249264e-07 / 2.15788202970697e-06 / 7.928931114532352e-06	3.24536E-06	3
183	PTGER3_2	0.0000000653	6.627915836434039e-07 / 2.668064610627935e-06 / 6.6526771052306895e-06	4.987581945086968e-07 / 6.416985820926155e-07 / 1.042398266072424e-06	3.32784E-06	3
184	CACHD1_2	0.0000000001	6.841823795764238e-06 / 1.1611327091078624e-06 / 3.757056495538064e-06	6.036905353459894e-07 / 1.7240231306506295e-06 / 2.495170691986825e-05	3.92E-06	3
185	VPS37D_2	0.0000000001	8.999654334938381e-06 / 3.0621601602130305e-06 / 2.72061163246224e-07	5.620700861394285e-07 / 1.1802005266016428e-06 / 1.1362044976111473e-06	4.11129E-06	3
186	ZDHHC17_1	0.0000000110	1.3062838211579366e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07	1.9472709844203468e-07 / 8.64813860440053e-09 / 4.08973006429415e-08	7.55908E-06	3
187	TMEM9B_2	0.0000000138	1.0001419899907697e-05 / 2.088214452889034e-05 / 3.1085970554200676e-07	7.663345318857788e-08 / 9.904773066152364e-07 / 1.645825440209025e-06	1.03981E-05	3
188	HOXD10_1	0.0000000921	2.7109747094287326e-07 / 3.1219185299958266e-05 / 9.224071980226081e-07	2.565463018954012e-06 / 1.941433683772925e-06 / 4.178051372181341e-06	1.08042E-05	3
189	ITFG2_1	0.0000005163	4.559947241482223e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06	3.439076468267492e-06 / 5.9260015900657735e-06 / 5.4469810926531135e-05	2.36273E-05	3
190	EGFL7_1	0.0000000299	1.1263759452799203e-06 / 4.369070707050029e-05 / 0.00018252021476464813	1.8700341255096223e-09 / 5.293074654152259e-06 / 1.2852959762944565e-05	7.57791E-05	3
191	PPP2R2A_5	0.0000000000	2.3018920608566846e-05 / 2.515879541149387e-06 / 0.00026563530537353084	2.892554421707878e-06 / 2.79139624836141e-06 / 0.0002549462415116326	9.70567E-05	3
192	BRF2_2	0.0000000001	9.751314166241359e-06 / 0.0003129016625892748 / 0.00016417889880625215	3.759229641754634e-08 / 2.1837529883578724e-05 / 1.5455954512499827e-06	0.000162277	3
193	ATP1B2_1	0.0000007792	8.350565572888588e-05 / 0.0003022930393277112 / 0.00012034822430170891	4.9185008634943495e-06 / 1.749159859965176e-05 / 1.758385056892761e-05	0.000168716	3
194	PTGES3_2	0.0000000002	0.00028889915694293186 / 0.0004343373075467472 / 2.3874708929429098e-06	6.3806928808699615e-06 / 3.6976674058849736e-07 / 2.590931905512812e-06	0.000241875	3
195	NR0B1_2	0.0000000017	0.00095500393558891 / 4.835640776889601e-06 / 1.3401582342156554e-08	0.00012317884029827643 / 9.41313565329906e-05 / 1.946170412794958e-05	0.000319951	3
196	GALNT10_2	0.0000073319	0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612	4.2967502063254294e-08 / 2.7580106394921852e-08 / 1.6050811528160658e-07	0.000539547	3
197	TMEM229A_1	0.0000019763	1.1263759452799203e-06 / 0.0017875715263402634 / 2.051237402337122e-05	4.470056894883235e-08 / 3.212400793996756e-05 / 3.0330851096686316e-06	0.00060307	3
198	NCEH1_1	0.0000021880	0.0025176594807100345 / 2.9249667673039124e-05 / 0.00049387566368266	2.9852999237846436e-07 / 3.6664065520662378e-06 / 1.4296784245243089e-06	0.001013595	3
199	C1orf27_1	0.0000005347	2.4400796134349794e-05 / 0.00048683461556788134 / 0.004468346085026116	3.3728825978612466e-08 / 1.7773181504273556e-05 / 1.1552987857913018e-05	0.00165986	3
200	TMEM14C_1	0.0000014171	0.00013494197652300576 / 0.008044269920970437 / 0.00043124882395994033	1.4472691259712559e-07 / 6.268977803019969e-07 / 2.4350896869975287e-07	0.002870154	3
201	DKK3_1	0.0000003462	0.0013248126277991738 / 0.0010602701525608943 / 0.008185982685681903	1.5846200021034092e-07 / 9.094647997910571e-07 / 1.069596462403796e-05	0.003523688	3
202	LRRC4C_1	0.0000000007	0.001612584660708291 / 0.008357898545557461 / 0.004641723683002966	5.839066787020226e-06 / 8.030484942525321e-05 / 2.874321825060119e-06	0.004870736	3
203	HOXD9_1	0.0000001816	0.003521766194763358 / 0.009358203838825317 / 0.006565901152596447	8.908782275302052e-08 / 1.4262192253107675e-06 / 1.1653976873204907e-05	0.006481957	3
204	SLC5A6_2	0.0000083594	0.00329856915210616 / 0.016629670900162985 / 0.003718378687262143	3.9237422990064166e-08 / 2.1675313933802943e-06 / 3.4461744463603383e-07	0.007882206	3
205	LYPD1_1	0.0039884477	0.00561851618326168 / 0.010298037138015295 / 0.011465748499709204	0.00012364715000227235 / 7.610927192464296e-06 / 3.436634759679429e-05	0.009127434	3
206	CIB1_1	0.0000012582	2.4400796134349794e-05 / 0.025949952318682364 / 0.005327800743076973	6.521419935683383e-08 / 0.0001508899394071643 / 2.7037258898085093e-06	0.010434051	3
207	PDSS1_2	0.0000001438	2.087686423298029e-05 / 0.032547979119801014 / 0.0009731125399429332	9.181067152023525e-08 / 1.866363701474153e-07 / 7.882821468850854e-06	0.011180656	3
208	SHC2_1	0.0000043527	0.008666672397448167 / 0.01221055371440681 / 0.023108053632132773	3.5046868808471237e-08 / 1.4152639674778885e-07 / 1.1044438525648634e-06	0.01466176	3
209	ATP6V0B_1	0.0000652113	0.0017008783545293586 / 0.03338582426278086 / 0.022359654779542756	1.8156513888722432e-05 / 0.0006738450240411453 / 0.00015710780312305387	0.019148786	3
210	SEPSECS_1	0.0000880523	0.03187722870624648 / 0.03280798665424235 / 0.039867021959100635	2.337882197149697e-08 / 1.6555950610598878e-06 / 2.8381722284939996e-06	0.034850746	3
211	BHLHE22_2	0.0000000002	1.3401582342156554e-08 / 4.659755401849588e-08	1.3361783713514048e-06 / 9.916119753409963e-07	2.99996E-08	2
212	FOXC1_1	0.0000001081	3.2501044823812903e-07 / 9.224071980226081e-07	2.464261525645891e-06 / 8.614020001816719e-06	6.23709E-07	2
213	DMRTA1_1	0.0000001005	1.0687433356337492e-05 / 7.348784993241683e-08	1.8860719855838867e-06 / 7.505602457021459e-06	5.38046E-06	2
214	CRYBG3_2	0.0000000000	7.842763361037193e-06 / 6.517914638754384e-06	1.266977339256832e-07 / 1.1569843022665961e-05	7.18034E-06	2
215	ANKRD28_1	0.0000001762	3.2501044823812903e-07 / 2.0071481202007584e-05	2.0833362771380855e-07 / 1.1004838243302006e-06	1.01982E-05	2
216	ZNF467_3	0.0000000000	1.6294904067329883e-05 / 1.3870388730546243e-05	7.288715501245973e-07 / 2.038126089530678e-07	1.50826E-05	2
217	MCU_1	0.0000000041	4.559947241482223e-05 / 2.7109747094287326e-07	0.00014805201662727028 / 1.3235442660276658e-05	2.29353E-05	2
218	ALG6_1	0.0000000034	4.559947241482223e-05 / 9.289397717877934e-06	7.757632613398362e-05 / 1.8142742683524817e-06	2.74444E-05	2
219	DST_1	0.0000000354	1.1263759452799203e-06 / 0.00018252021476464813	2.5055687616812065e-08 / 7.501693754343125e-06	9.18233E-05	2
220	CNOT6_1	0.0000000101	1.1263759452799203e-06 / 0.0002944288613709527	1.1075622702926509e-08 / 1.129572691211572e-06	0.000147778	2
221	SLC25A46_1	0.0000002913	0.00036105139567184824 / 0.00014547367344876742	2.5994147109530116e-05 / 4.968741535651153e-06	0.000253263	2
222	STRBP_3	0.0000000000	1.5669300524965997e-07 / 0.0005064725174938412	1.481967113051988e-07 / 1.3155160149040273e-05	0.000253315	2
223	SLFN11_1	0.0000000685	2.4400796134349794e-05 / 0.00048683461556788134	1.0022702721591722e-05 / 9.972925901562962e-06	0.000255618	2
224	IL1R1_1	0.0000016239	0.000617308483698201 / 6.569591094283755e-05	4.5432680388905903e-07 / 9.107588752182431e-08	0.000341502	2
225	PDE9A_2	0.0000000400	0.00041731220668757806 / 0.0005855390414154741	1.221895236718122e-05 / 4.308375284196633e-07	0.000501426	2
226	TXNDC11_1	0.0000008009	0.00037816990481376106 / 0.001675382961010776	3.35563055514752e-05 / 1.6158804956085833e-05	0.001026776	2
227	NRP1_2	0.0000038002	0.0004994794183737504 / 0.002324394606725177	5.465744973286784e-06 / 7.656204640097829e-05	0.001411937	2
228	QSER1_1	0.0000182809	0.0013570458512569155 / 0.002178697316418811	9.58284147411479e-06 / 8.84455021841255e-06	0.001767872	2
229	TNIP1_1	0.0000036678	5.198191671140737e-06 / 0.004144214246475889	6.508715673074529e-09 / 0.00019241774459470402	0.002074706	2
230	LIMS1_1	0.0000029556	0.0018263671837831345 / 0.0029439691339069544	1.6606027203704394e-06 / 2.8416546588022426e-06	0.002385168	2
231	PNISR_1	0.0000015994	0.0010325370165401593 / 0.00423890420622936	1.0714836567004093e-06 / 4.211924899648025e-05	0.002635721	2
232	MOAP1_1	0.0001095279	0.0013957283134908426 / 0.004002216537936575	1.439059920097413e-05 / 4.3262437480883325e-07	0.002698972	2
233	KAT2B_3	0.0000000754	0.00036235601618888415 / 0.0056682839670987315	7.275549292242543e-06 / 6.222503271842437e-05	0.00301532	2
234	NBAS_2	0.0001936498	0.002248148734104571 / 0.003937219671693211	5.238094547402913e-05 / 2.261642163972036e-05	0.003092684	2
235	RPAP3_1	0.0000000959	0.006578021053153416 / 0.0003022930393277112	0.00010709405231539574 / 5.7996012896130105e-05	0.003440157	2
236	PCDH8_1	0.0000003649	0.001612584660708291 / 0.0053998526759721725	6.979705922681422e-07 / 2.352485760414308e-06	0.003506219	2
237	NRTN_1	0.0000000085	0.006576322331343084 / 0.000682440200485821	1.3872766655850854e-09 / 1.1570279948530293e-08	0.003629381	2
238	NFE2L3_3	0.0000025415	0.006071092121717285 / 0.001441190253067779	0.0007954168620537718 / 2.313845386160375e-05	0.003756141	2
239	AXL_2	0.0000082526	0.004702764394990607 / 0.0030062439789624545	1.694397819105341e-07 / 2.938209735715061e-06	0.003854504	2
240	FAM84B_1	0.0000011219	0.00253490211532945 / 0.006638130601347837	9.817330455454356e-07 / 1.8299892086956357e-05	0.004586516	2
241	SERPING1_2	0.0000000003	0.00029302171972017536 / 0.00899955161467775	5.171117305573901e-07 / 3.4719444187468846e-06	0.004646287	2
242	MAN2A2_1	0.0000016596	0.008666656930380014 / 0.0017164152096634118	3.010976905505238e-07 / 1.2681089550233342e-06	0.005191536	2
243	PPP1R1B_2	0.0000081910	0.0007369895164838126 / 0.015544944078315552	4.952255809431967e-06 / 0.0008507571424411441	0.008140967	2
244	LIM2_1	0.0000574583	0.015037462614525989 / 0.0066321488107590094	1.3552898512014677e-07 / 1.5995954452124522e-06	0.010834806	2
245	ENC1_1	0.0000008380	0.019200633106000394 / 0.0072430591690685955	9.369739248583604e-07 / 9.796657658766679e-08	0.013221846	2
246	TXNDC15_1	0.0002035799	0.01560397243862297 / 0.026007387241751754	1.3487999148831977e-05 / 2.383861518054849e-06	0.02080568	2
247	CTGF_1	0.0006621219	0.04284073842146925 / 0.004328209862304807	1.2802249170334234e-06 / 4.161322882701981e-06	0.023584474	2
248	EGFLAM_2	0.0000009904	9.101668425963222e-05 / 0.04959722009227676	2.2688565832705132e-07 / 4.996639973079422e-06	0.024844118	2
249	ARHGAP10_2	0.0000000002	1.0829140297466289e-09	3.358932763107935e-10	1.08291E-09	One
250	EBF3_1	0.0000002820	2.7109747094287326e-07	1.8343370720153953e-05	2.71097E-07	One
251	PLAGL2_1	0.0000000508	3.2501044823812903e-07	1.8455903922148852e-07	3.2501E-07	One
252	XKR4_3	0.0000000000	3.984768315573071e-07	3.1239365009333255e-05	3.98477E-07	One
253	HR_1	0.0000000121	9.224071980226081e-07	1.9179741330821166e-06	9.22407E-07	One
254	GLB1L2_1	0.0000000160	1.1263759452799203e-06	7.033045636092652e-08	1.12638E-06	One
255	GOLIM4_1	0.0000004900	1.1263759452799203e-06	6.007938707379104e-06	1.12638E-06	One
256	TMEM127_1	0.0000000593	1.1263759452799203e-06	4.773025688625418e-08	1.12638E-06	One
257	USP21_1	0.0000003387	1.1263759452799203e-06	9.225028218311642e-07	1.12638E-06	One
258	FAIM_5	0.0000000000	1.1673685534992903e-06	9.826697889420593e-07	1.16737E-06	One
259	COX19_2	0.0000000297	2.674810306988624e-06	6.962982384295879e-06	2.67481E-06	One
260	LRP10_3	0.0000000000	4.146152323500948e-06	2.8381722284939996e-06	4.14615E-06	One
261	ASPH_1	0.0000031107	5.198191671140737e-06	1.24607424448712e-09	5.19819E-06	One
262	CASP4_1	0.0000231527	5.198191671140737e-06	8.920036916236078e-07	5.19819E-06	One
263	PPFIBP1_1	0.0000009218	5.198191671140737e-06	2.822471900981502e-07	5.19819E-06	One
264	PRRX2_1	0.0000102422	5.198191671140737e-06	1.997454040091158e-06	5.19819E-06	One
265	TADA1_1	0.0000011043	5.198191671140737e-06	4.130298014547339e-06	5.19819E-06	One
266	FBXO15_2	0.0000000001	7.752739683840974e-06	1.0459642383728147e-08	7.75274E-06	One
267	RPRD1A_3	0.0000000001	1.0121621258597313e-05	5.117366799673119e-08	1.01216E-05	One
268	HS3ST3B1_2	0.0000000001	1.589621421980893e-05	5.712322089852472e-05	1.58962E-05	One
269	RBM39_1	0.0000000427	1.615375160694009e-05	1.0486585374452342e-06	1.61538E-05	One
270	MRPS34_1	0.0000059445	2.078130544858706e-05	3.007629978522511e-07	2.07813E-05	One
271	PPARD_1	0.0000000391	2.4400796134349794e-05	1.781378071484659e-07	2.44008E-05	One
272	TRIM29_2	0.0000000342	2.5328503789616034e-05	3.171256366090173e-06	2.53285E-05	One
273	SLITRK3_2	0.0000000001	2.606975599460185e-05	1.5642166542934073e-05	2.60698E-05	One
274	AOX1_1	0.0000000161	2.9249667673039124e-05	1.5889876142270276e-06	2.92497E-05	One
275	WDR41_1	0.0000008795	3.490933492066787e-05	0.00031815123884038185	3.49093E-05	One
276	WDR60_1	0.0000000100	3.54688199707126e-05	5.069649573469536e-05	3.54688E-05	One
277	ELOVL1_1	0.0000000046	3.613318380627543e-05	2.329132806551381e-05	3.61332E-05	One
278	ISYNA1_1	0.0000000671	4.335544688590604e-05	1.6739811178590666e-07	4.33554E-05	One
279	BTBD17_1	0.0000001085	4.559947241482223e-05	5.155148635414614e-07	4.55995E-05	One
280	E2F6_1	0.0000000779	4.559947241482223e-05	1.7462091622562324e-05	4.55995E-05	One
281	REEP5_1	0.0000012251	4.559947241482223e-05	4.0559240566408105e-05	4.55995E-05	One
282	HIF3A_2	0.0000001724	5.1802263378395004e-05	7.343981030754773e-06	5.18023E-05	One
283	PLIN3_1	0.0000007202	7.498301012054149e-05	8.715915351978061e-08	7.4983E-05	One
284	SLC25A43_1	0.0000000584	7.498301012054149e-05	1.042304728724042e-06	7.4983E-05	One
285	NINL_2	0.0000000000	8.157777488089495e-05	1.9047854067387114e-06	8.15778E-05	One
286	ZNF232_2	0.0000000005	9.615096996117447e-05	2.7228077881606553e-05	9.6151E-05	One
287	SIRT4_5	0.0000000006	9.759198409764184e-05	0.00022059348443664346	9.7592E-05	One
288	TP53BP2_1	0.0000015006	0.00011602560329098725	1.0705081193459222e-06	0.000116026	One
289	DLGAP1_1	0.0000000768	0.0001432193232982916	3.5620325640614317e-07	0.000143219	One
290	ELL2_1	0.0000001831	0.00014547367344876742	1.8060650315234512e-06	0.000145474	One
291	L3MBTL1_1	0.0000000672	0.00015165886425239433	2.7256307870565235e-06	0.000151659	One
292	VCL_1	0.0000000164	0.00015165886425239433	3.3683533578357084e-06	0.000151659	One
293	FOXN4_1	0.0000000718	0.00018648294090879803	6.71170895523933e-08	0.000186483	One
294	DGKD_2	0.0000000001	0.00021891772305978252	3.0596605696933097e-07	0.000218918	One
295	UHMK1_2	0.0000022832	0.0002538027145357861	1.287838376941801e-06	0.000253803	One
296	ATG10_1	0.0000013709	0.00045105792374135455	1.9817995812370057e-05	0.000451058	One
297	RTN4_1	0.0000004000	0.0005279514394131604	2.4302265052169763e-06	0.000527951	One
298	ZBTB34_2	0.0000000006	0.000905796995991497	2.480782410785219e-06	0.000905797	One
299	TRAPPC1_1	0.0000002410	0.0009321635980700065	5.038494138176741e-08	0.000932164	One
300	MAN1A1_1	0.0000012120	0.0010091155669931342	9.89628655829039e-07	0.001009116	One
301	GPR155_1	0.0000001571	0.0010353911778693099	2.456527177029259e-08	0.001035391	One
302	NUP205_1	0.0000011129	0.0012133361599562802	4.618395361515403e-05	0.001213336	One
303	DFNA5_1	0.0000000842	0.0013248126277991738	1.0306269703522314e-06	0.001324813	One
304	ESYT2_1	0.0000000362	0.0014584828902455792	1.480537378886556e-06	0.001458483	One
305	ARRDC5_1	0.0000004478	0.0016631235717637551	5.470825563951457e-06	0.001663124	One
306	WWOX_1	0.0000000652	0.001710012299865077	3.466057717888151e-05	0.001710012	One
307	TTC12_1	0.0000000828	0.001757554115983901	1.1207466412214644e-06	0.001757554	One
308	PHLDA1_1	0.0000002242	0.0025176594807100345	2.681228774385004e-07	0.002517659	One
309	USP44_2	0.0000000006	0.002828735395322951	7.615307891070635e-07	0.002828735	One
310	PLTP_1	0.0000001423	0.0037115156714849027	6.256739082396771e-06	0.003711516	One
311	FOXK2_2	0.0017280500	0.004268133535531114	1.124004668909467e-06	0.004268134	One
312	ERRFI1_1	0.0000343124	0.004549100059734061	2.615853467480574e-06	0.0045491	One
313	NCAPG2_2	0.0000096301	0.004679455399141524	3.410090272140929e-05	0.004679455	One
314	GNG12_2	0.0000008966	0.004702764394990607	2.448152787066068e-07	0.004702764	One
315	GTF2IRD1_2	0.0000000000	0.005180332874805364	1.0191189286267774e-05	0.005180333	One
316	CDH13_1	0.0000528396	0.008698504315979544	5.505206380486848e-07	0.008698504	One
317	USPL1_1	0.0000887089	0.008919618004927028	2.867060371186775e-05	0.008919618	One
318	C8orf33_2	0.0000000686	0.012040847937930112	6.965053271201718e-06	0.012040848	One
319	LARP4_1	0.0000539238	0.012598829000918008	1.5446384568414948e-07	0.012598829	One
320	WISP2_3	0.0007560493	0.015549504727258205	4.1338081640385414e-05	0.015549505	One
321	ACTR3B_1	0.0000005421	0.01578579910468178	2.8755424998338056e-06	0.015785799	One
322	CACNA1H_1	0.0000005564	0.016412811603890378	2.7000252287495107e-06	0.016412812	One
323	KIT_5	0.0000464952	0.018517123226998455	6.704030752101419e-08	0.018517123	One
324	PFKFB4_1	0.0000652997	0.020508581406833964	3.9540280994682333e-05	0.020508581	One
325	PRKCA_1	0.0000002757	0.022453642395359744	8.550515929117645e-06	0.022453642	One
326	PPIB_1	0.0005395298	0.022633220383071653	1.1620529438552381e-07	0.02263322	One
327	GUK1_1	0.0002165806	0.025889538503308045	0.00027733726642677973	0.025889539	One
328	TOMM20_1	0.0000295101	0.026424697119045135	5.7696335620157635e-06	0.026424697	One
329	MCFD2_1	0.0000296801	0.02889039127169977	5.21788791253075e-06	0.028890391	One
330	ARL2BP_1	0.0009748737	0.03656942798482464	2.769366837708274e-07	0.036569428	One
331	DSTN_2	0.0000209668	0.040590852862758056	0.0002808473162478281	0.040590853	One

Next, a biomarker that affects the reactivity to drugs for each drug type, calculated through GBLscan using the functional Haflow type in the present invention, will be described.

Specifically, by type of drug type (Drug Class), 108 biomarkers of ABL (see Table 15), 132 biomarkers of CHROMATIN (see Table 16), 832 biomarkers of EGFR (see Table 17), ERK_MAPK There are 42 biomarkers (see Table 18), 153 biomarkers of IGFR (see Table 19), and 88 biomarkers of MITOSIS (see Table 20).

[Table 15] to [Table 20] below include biomarkers discovered by the present invention for each drug type. Here, the form and expression method of the biomarker are the same as the biomarker classified for each cancer type.

Definition of drug type (DrugClass) targeting specific pathway & signaling

division	DrugClass	Drugs	Pathway & signaling (Target gene & function)
One	ABL	Imatinib, GNF-2, Dasatinib, Saracatinib, WH-4-023, Bosutinib, Ponatinib, HG-5-113-01, Nilotinib	ABL, SRC, KIT, PDGFR, ABL1, TEC, LOK, LTK, TRCB,
2	CHROMATIN	Phenformin, AICA_Ribonucleotide, Daporinad	HDAC, RAR, HDAC inhibitor Class I, IIa, IIb, IV; HDAC6, EGFR, G9a (EHMT2), GLP (EHMT1), Q8TEK3 (DOT1L), BRD2, BRD3, BRD4
3	EGFR	Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714, Pelitinib	ERBB2, EGFR, ADCK4
4	ERK_MAPK	Dabrafenib, VX-11e, AZ628, Selumetinib, CI-1040, PD0325901, Selumetinib, Refametinib, Trametinib, TL-2-105, HG6-64-1, PLX-4720, SB590885, SL0101, CMK, FMK, FR = 180204	MAP2K1 (MEK1), MAP2K2 (MEK2), BRAF, ERK, RSK, AURKB, PIM3, CRAF, BRAFV600E, TAK, MAP4K5
5	IGFR	CSK1904529A, BMS-536924, BMS-754807, Linsitinib	IGF1R
6	MITOSIS	Dacinostat, JQ1, SGC0946, VNLG / 124, UNC0638, Belinostat, CUDC-101, Vorinostat, CAY10603, AR-42, I-BET-762, Tubastatin A, PFI-1, Entinostat, JQ12	AURKB, MPS1, KIF11, AURKA, PLK3, AURKC, FLT3, ABL1, JAK2, PLK3

Table 15 shows the biomarkers associated with ABL drugs and the degree of reactivity (P-value) of the drugs.

In Table 15, FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the value of the correlation (P-vlaue) of the marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 37, correlation values (P-vlaue) values of ABL drugs of major biomarkers among the biomarkers described in [Table 15] are graphically displayed.

Reactive biomarker for ABL drug and verification result of reactivity with drug

No.	FRH	Variants	Var_Drug (pval)	Var_Exp (Pval)
One	MEI1_1	22_41743050_G_A	4.85E-06	0.048265101
2	MYO1E_1	15_59223315_G_A	9.45E-06	0.007356789
3	HSPG2_1	1_21855190_T_G	3.11E-05	0.047030976
4	DUS1L_1	17_82060026_C_T	3.91E-05	0.03583129
5	ANXA2_1	15_60382524_A_G	5.75E-05	0.01380595
6	CDA_1	1_20613970_T_C	0.000123749	0.01233326
7	R3HDM1_1	2_135621624_GT_G	0.000150326	0.007933574
8	HMGB1_1	13_30465849_T_C	0.000160907	1.54E-07
9	TRIM35_1	8_27311444_G_A	0.000300142	0.010188344
10	NMT2_1	10_15119275_A_C	0.000338877	0.015194231
11	WWC1_1	5_168453939_T_G	0.000400908	0.007809824
12	EPB41_1	1_28987461_G_A	0.000407874	0.032052572
13	TGS1_1	8_55790504_CT_C	0.000507403	0.000527822
14	CLIP4_1	2_29189528_C_T	0.000680402	0.012550596
15	PPFIBP1_1	12_27671307_G_A	0.000932648	0.043451196
16	GNG12_1	1_67707581_C_T	0.000988807	0.022170841
17	MATN3_1	2_20002159_T_TACAC	0.000997596	0.02071966
18	LAMA5_1	20_62325178_T_C	0.001153135	0.010970602
19	SECISBP2_1	9_89319872_A_G	0.001203729	0.020014055
20	CARD10_1	22_37506170_T_C	0.001543214	0.032625328
21	CELF3_1	1_151714507_T_A	0.001901287	0.026406472
22	RPRD2_1	1_150470594_A_C	0.002054115	0.049994398
23	LONP1_1	19_5707040_C_G	0.002145064	0.014919269
24	CELSR1_1	22_46397746_T_G	0.002174791	0.029193759
25	AVPI1_1	10_97677649_A_G	0.002288252	0.001581419
26	HEATR5A_1	14_31321626_G_C	0.002664426	0.037377577
27	ABCC3_1	17_50687493_T_G	0.002687235	0.008875192
28	BCL9L_1	11_118897861_A_C	0.003330363	0.034238861
29	ATP9A_1	20_51712877_T_C	0.003711948	0.007942465
30	PPL_1	16_4899248_T_G	0.003916476	0.036032874
31	WTIP_1	19_34482571_G_A	0.004231715	0.04930162
32	SEC11C_1	18_59152698_T_C	0.004414812	0.00225746
33	RIN2_1	20_19990244_G_A	0.004460992	0.013004393
34	VPS13C_1	15_61910091_C_T	0.004506626	0.031208891
35	WAS_1	X_48691219_A_C	0.004569497	0.02612273
36	ITGA2_1	5_53062931_TA_T	0.005690843	0.016066848
37	SNX6_1	14_34581380_G_T	0.006210652	0.003379828
38	ITGB5_1	3_124769064_T_G	0.006500498	0.000658854
39	KIF13A_1	6_17796543_CTT_C	0.006766834	0.022643788
40	HNRNPD_1	4_82373387_A_G	0.006955259	0.035424294
41	PDE7A_1	8_65724444_TATAA_T	0.006982791	0.049491005
42	TAB1_1	22_39417620_CA_C	0.007324331	0.041922448
43	TSPAN17_1	5_176657159_A_G	0.009147394	0.031164715
44	MYO1C_1	17_1484178_C_T	0.009858187	0.007802374
45	CDC42BPA_1	1_227318293_C_CG	0.010493359	0.000358115
46	ACTN4_1	19_38728028_T_G	0.011156467	0.005408687
47	MET_1	7_116757685_T_G	0.012677621	5.06E-05
48	GPC1_1	2_240451010_T_G	0.013814172	0.00346274
49	HERC1_1	15_63725445_C_A	0.014048274	0.007901005
50	RAB13_1	1_153982198_T_C	0.015384036	0.007436568
51	UBE2N_1	12_93411182_C_T	0.015885474	1.51E-06
52	STRBP_1	9_123266116_C_G	0.017136074	0.001078377
53	EZH1_1	17_42729015_C_CA	0.018478925	0.00312166
54	RNASEH2B_1	13_50956394_G_T	0.01852788	0.005925233
55	LTBP3_1	11_65547976_T_G	0.019306265	0.001002058
56	EGFR_1	7_55205662_A_C	0.020078083	0.000779757
57	LPIN3_1	20_41358465_C_G	0.020089538	6.89E-05
58	PHF21A_1	11_46079428_CT_C	0.020895851	0.00265565
59	SPR_1	2_72891611_A_C	0.021434042	0.000101783
60	RCHY1_1	4_75509142_T_A	0.022232183	7.00E-06
61	EPHA2_1	1_16148437_A_C	0.023495387	0.003022958
62	GMEB1_1	1_28690201_G_T	0.025608914	0.005247117
63	KRI1_1	19_10565667_A_T	0.026306225	2.71E-07
64	MADD_1	11_47325027_T_C	0.027877784	0.001497343
65	ITGAV_1	2_186622542_G_T	0.027935094	0.000708467
66	FN1_1	2_215384980_GA_G	0.028277863	0.006411138
67	ITGB8_1	7_20404676_A_G	0.03058173	0.00229404
68	MYOF_1	10_93341723_C_T	0.031403296	1.02E-05
69	MICALL1_1	22_37911902_T_C	0.031573614	0.005136303
70	TXNL4A_1	18_80033872_T_C	0.035325542	0.000843174
71	AHR_1	7_17339074_A_C	0.036910472	0.009928124
72	HCFC1_1	X_153963207_T_G	0.040430125	0.001579155
73	TJP1_1	15_29761137_A_C	0.040841908	0.005695684
74	DPF1_1	19_38216453_A_C	0.041618699	0.002769532
75	TUFT1_1	1_151565936_G_A	0.042197322	0.004559558
76	CNN3_1	1_94903018_TA_T	0.044343955	0.002044509
77	CALD1_1	7_134891710_CTT_C	0.044361406	0.006749784
78	DCP1A_1	3_53342054_G_C	0.044944752	0.003471409
79	CNBP_1	3_129183756_G_T	0.045255004	0.001660507
80	CDC42BPB_1	14_102952453_T_G	0.046084899	0.003315245
81	ZNF557_2	19_7083618_A_G / 19_7083750_A_G	0.00011707290070365984 / 6.389914683218769e-05	1.6329734686551152e-07 / 4.640996358288638e-07
82	TSC22D1_2	13_44574373_G_T / 13_44436480_G_A	0.00011795878001107085 / 0.0037018440403040202	0.0064804726533923464 / 0.03180017409101453
83	KDM2B_2	12_121579943_C_CA / 12_121444386_T_G	0.0001937979358872413 / 0.00792596940180308	0.01794421156168876 / 0.019501973878425127
84	TMEM206_3	1_212365230_C_T / 1_212377513_G_A / 1_212377773_C_T	0.00020121681284993422 / 0.0003349904631200686 / 5.8829810838971604e-05	0.015527989364148976 / 0.03220676605475732 / 0.012309846725869236
85	CNOT10_2	3_32727933_TAA_T / 3_32704796_GT_G	0.0004336510041481753 / 0.008993061026214434	0.009535253937430231 / 0.00725632017358903
86	AHNAK2_6	14_104939818_T_C / 14_104947943_T_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950989_T_C / 14_104944923_A_G	0.0013733032135289033 / 9.993054536650758e-05 / 0.0009826292819827367 / 0.008303598761450906 / 0.009151781473220755 / 0.016815570915054142	0.0009255099251631373 / 0.014057846162243957 / 0.00506490504122054 / 0.005256944789299486 / 0.039201386575838416 / 0.004782218518041667
87	HNRNPH1_2	5_179614784_GAAAAA_G / 5_179616992_TA_T	0.0015622332101704927 / 0.013101283499781437	0.009729395921872941 / 0.006282233288170697
88	KCTD11_2	17_7355768_G_A / 17_7353417_T_G	0.0021551269324258863 / 0.011987917410278012	0.042125567363077016 / 0.0012683162409826913
89	DCBLD2_2	3_98800637_G_A / 3_98822022_G_A	0.002171037536345973 / 0.000251692831370466	0.02405283820151249 / 0.02321925017861924
90	MICALL2_6	7_1434706_A_T / 7_1436884_C_A / 7_1436960_A_G / 7_1434574_G_A / 7_1438692_G_A / 7_1438940_G_A	0.0035785281207345704 / 0.005806506395454868 / 0.0023336782590812483 / 0.003953693182824404 / 0.01322256820373324 / 0.01322256820373324	0.03116600791585888 / 0.020144032243767682 / 0.0387968938865376 / 0.018579241850634483 / 0.001706040259270731 / 0.001706040259270731
91	YEATS4_3	12_69360050_G_A / 12_69360067_T_C / 12_69359732_G_C	0.004863813186856697 / 0.017375818716536366 / 0.03137776422130159	0.00020734016607029562 / 9.576513142549652e-05 / 0.00015854860163792644
92	FAM129B_2	9_127505498_C_G / 9_127507507_A_G	0.0058285941972244645 / 0.02690463941303876	0.011307547073529664 / 0.009068416405751362
93	DAZAP1_2	19_1432575_T_C / 19_1434836_G_C	0.007270894232908141 / 0.04710249822900437	0.008783799588482919 / 0.0025498805972486143
94	TRIO_2	5_14390880_CT_C / 5_14489165_TA_T	0.008880626014071066 / 0.01650056581622358	7.026077789590974e-05 / 0.0025442006562780626
95	LTBR_2	12_6385217_T_C / 12_6385074_A_G	0.009079148191429435 / 0.006460458599235777	9.805545850814532e-05 / 0.044833733345219534
96	CRIM1_2	2_36479368_G_C / 2_36441370_A_C	0.009119609813496462 / 0.019906184227680684	0.012444715286562538 / 0.003648330338783967
97	LRRC1_2	6_53795560_C_T / 6_53922469_G_C	0.01198676814286411 / 0.0006843529222630762	0.000908035692517222 / 0.04843244804719673
98	PLEC_3	8_143935900_T_G / 8_143916360_A_G / 8_143919099_A_G	0.014640529544546175 / 0.009983558087568838 / 0.034402276881097434	0.0004960012901022363 / 0.00910116635228719 / 0.0010288222361061275
99	CCAR1_4	10_68737725_A_G / 10_68749117_T_C / 10_68786466_C_T / 10_68747145_CT_C	0.01483460962771855 / 0.019812419206917474 / 0.021724978822350548 / 0.012199365670034771	0.007861846127742463 / 0.007748422295395019 / 0.009002153564015953 / 0.007417608363424872
100	PBRM1_10	3_52550415_T_TCTC / 3_52550699_A_G / 3_52576635_T_A / 3_52603470_C_G / 3_52609291_A_G / 3_52658108_G_A / 3_52658343_C_G / 3_52642048_AC_A / 3_52642050_A_T / 3_526412	0.015475400089384512 / 0.0016628718776702444 / 0.035404535122126136 / 0.013312042665148668 / 0.0242839606361519 / 0.02159841119723304 / 0.03729870903666122 / 0.025323429673084204 / 0.025323429673084204 / 0.0001941847064581337	0.0035430700286634563 / 0.0001926448792301472 / 0.007441673662340349 / 0.002758979013645352 / 0.0010612844220239503 / 0.004958532862731571 / 0.004683945580784586 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218
101	EPAS1_2	2_46356096_C_A / 2_46375583_T_C	0.01783131944184612 / 0.0010999393665466503	0.008349664569290316 / 0.024779624499683697
102	MYL12B_2	18_3277079_C_A / 18_3261766_G_T	0.02040887855273308 / 0.006963645724708455	0.0006636499143577351 / 0.002628020597022407
103	ASPH_3	8_61578734_T_G / 8_61642872_G_A / 8_61638365_TA_T	0.02703041744922913 / 0.04217140046834995 / 0.0037026849241301204	0.00027481062695969863 / 9.242250914202104e-05 / 0.0033421074285719613
104	CTTN_2	11_70433765_G_C / 11_70433037_T_G	0.028796315723836858 / 0.0215077683383786	0.008528354106314544 / 0.004388396641544275
105	GBP3_2	1_89009135_A_G / 1_89013185_G_A	0.03712796271516626 / 0.046403726190448136	2.531316619591342e-10 / 0.003766535351837685
106	RBM6_3	3_50077082_C_T / 3_50066484_G_A / 3_50075273_C_A	0.03754138190716002 / 0.009406589543431777 / 0.006286329345703225	4.469564601606787e-06 / 0.014325869585835831 / 0.04790544676634136
107	GULP1_2	2_188589974_C_CT / 2_188569425_C_A	0.04155742757047321 / 0.00797269939608827	0.004507263398919969 / 0.006203700518672077
108	RAI14_2	5_34822821_T_C / 5_34795871_A_G	6.659980942617595e-05 / 0.005987810799744655	0.002995737088482826 / 0.006423617908157835

Table 16 shows the biomarkers associated with the CHROMATIN drug and the degree of reactivity (P-value) of the drug by the table.

In [Table 16], FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the correlation (P-vlaue) value of the marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 38, correlation values (P-vlaue) values of CHROMATIN drugs of major biomarkers among the biomarkers described in [Table 16] are graphically displayed.

Reactivity biomarker for CHROMATIN drug and verification result of reactivity with drug

No.	FRH	Variants	Var_Drug (pval)	Var_Exp (Pval)
One	SPR_1	2_72891611_A_C	1.13E-09	0.000101783
2	BCL9L_1	11_118897861_A_C	3.13E-08	0.034238861
3	ZDHHC7_1	16_84981848_T_G	1.25E-07	0.007398316
4	CCDC69_1	5_151185396_T_C	2.83E-07	0.005439839
5	DDX60_1	4_168220820_G_T	4.91E-07	0.047715445
6	RASSF5_1	1_206507640_A_C	6.00E-07	0.042432506
7	C21orf58_1	21_46302477_A_G	5.32E-06	0.028316032
8	KIAA0922_1	4_153466445_G_C	1.35E-05	0.014460739
9	NR2F2_1	15_96331144_C_T	1.41E-05	0.041165877
10	WWC2_1	4_183261395_G_T	2.29E-05	0.017749371
11	ERRFI1_1	1_8013331_A_G	3.34E-05	0.000188249
12	KIAA1191_1	5_176361895_T_C	4.29E-05	0.02279099
13	QSOX1_1	1_180196892_T_G	5.61E-05	0.048904626
14	NTN4_1	12_95683554_A_C	5.86E-05	0.007698614
15	KIFC3_1	16_57765532_T_G	6.78E-05	0.038497261
16	LPP_1	3_188484677_T_G	7.25E-05	0.027828249
17	TUFT1_1	1_151565936_G_A	8.20E-05	0.004559558
18	CDC14B_1	9_96496393_T_TACC	0.000102442	0.034844355
19	DTX1_1	12_113093500_A_T	0.000105094	0.02107386
20	P4HA2_1	5_132227207_C_T	0.000133282	0.048816114
21	ARHGAP25_1	2_68818005_T_G	0.000231771	0.004043302
22	TIMM13_1	19_2425296_G_C	0.000236058	0.025389471
23	CAST_1	5_96741643_A_C	0.000249549	0.007284203
24	PTPN12_1	7_77627576_G_C	0.000317226	0.012844299
25	MED28_1	4_17614675_T_G	0.000322999	0.029816577
26	SLC35F5_1	2_113723196_TA_T	0.000333219	0.009792442
27	TPBG_1	6_82364929_T_C	0.000334942	0.003828919
28	CD79B_1	17_63932334_A_C	0.000528438	0.048052988
29	DIRC2_1	3_122856322_A_G	0.000825084	0.013416691
30	UEVLD_1	11_18558312_C_A	0.000960879	0.026771319
31	LRP10_1	14_22875577_A_C	0.001001744	0.013008771
32	UGDH_1	4_39504307_CA_C	0.001468644	0.048378289
33	VMP1_1	17_59841357_A_C	0.001495454	0.00700708
34	DOT1L_1	19_2190948_TTGG_T	0.001590625	0.039142783
35	OSMR_1	5_38933647_C_T	0.001601244	0.048095084
36	CYR61_1	1_85581605_TA_T	0.001618999	0.000620768
37	EMP1_1	12_13211531_T_G	0.001632317	0.001600571
38	PRDM2_1	1_13781628_C_T	0.001853506	0.028812792
39	UBE2N_1	12_93411182_C_T	0.001919604	1.51E-06
40	PDE7A_1	8_65724444_TATAA_T	0.001930609	0.049491005
41	ZNF775_1	7_150397765_G_A	0.002410672	0.02103353
42	ACSS2_1	20_34920910_T_G	0.002415783	0.038456731
43	TNRC6C_1	17_78049826_A_C	0.002419277	0.037719795
44	OPTN_1	10_13108909_T_C	0.002658339	0.009854403
45	FHL2_1	2_105398737_G_C	0.002849654	0.020214714
46	TSR2_1	X_54440646_T_G	0.003023868	0.016676081
47	PON2_1	7_95406313_A_C	0.003172125	9.37E-06
48	RIN2_1	20_19990244_G_A	0.003495398	0.013004393
49	ACVR1_1	2_157780624_GA_G	0.003989606	0.003394881
50	ARRB2_1	17_4720324_T_G	0.004024916	0.04522165
51	STRBP_1	9_123266116_C_G	0.005108062	0.001078377
52	APLP2_1	11_130110790_G_A	0.006767893	0.002129537
53	PPM1D_1	17_60656555_C_G	0.007483948	0.004279928
54	MICALL2_1	7_1442358_T_G	0.008296918	0.00384944
55	SDC4_1	20_45330303_T_G	0.00885313	0.000496261
56	MAP4K1_1	19_38617327_T_G	0.009035501	0.013203631
57	DDX51_1	12_132144264_G_A	0.00950629	0.039746501
58	CD63_1	12_55725568_A_C	0.010191282	0.006277176
59	TSEN34_1	19_54192354_T_G	0.015320711	0.001848481
60	RND3_1	2_150487464_GA_G	0.016355986	0.009852344
61	DYNC1LI2_1	16_66723584_GTTT_G	0.020987801	0.00547115
62	ATG4D_1	19_10547046_A_G	0.025677384	0.001170719
63	TEAD4_1	12_3019250_C_T	0.025841261	0.001625407
64	SPATS2L_1	2_200329386_C_A	0.025958546	0.003348759
65	TCF3_1	19_1627423_T_C	0.04297822	0.006623288
66	GPX8_1	5_55164338_T_C	0.043500083	0.000150103
67	CHD7_1	8_60781091_A_C	0.049386713	0.009144258
68	IQCB1_1	3_121788568_C_T	0.049430015	1.56E-06
69	CD84_2	1_160549875_A_G / 1_160550877_C_G	0.00011388443370850483 / 0.0007812325110491749	0.011914227680681896 / 0.04088607952168802
70	GSN_2	9_121300011_T_G / 9_121321305_A_C	0.00014939533964484881 / 0.03316947281106813	0.027350252864946387 / 0.0036521684936499576
71	PTPRC_2	1_198703381_A_C / 1_198752063_T_C	0.00016494389721910315 / 0.0013479983597789753	0.02703768662070396 / 0.04525193826667434
72	DAG1_2	3_49531399_T_G / 3_49530812_A_G	0.00020026524182288077 / 0.006009115344867996	0.000829773140052924 / 0.031395065099950874
73	CLEC16A_3	16_11156556_C_A / 16_11060913_G_A / 16_11042191_C_G	0.0002094249249848047 / 6.263351817687237e-07 / 0.000591215275919509	0.00562768771681351 / 0.001657798405900209 / 0.0008509758531100063
74	SEMA3C_2	7_80748927_A_C / 7_80758439_T_G	0.00023588106210457256 / 0.002402247845707725	0.04566908222348532 / 0.022537466343331126
75	MYO1E_3	15_59272288_G_C / 15_59223315_G_A / 15_59138181_A_C	0.0002531868313324391 / 0.017294701356675626 / 0.012353995820357604	0.006181875879725325 / 0.0073567891788311425 / 0.000506485287819266
76	FBRSL1_2	12_132582046_C_T / 12_132490757_A_G	0.0002541174963279791 / 0.0016132414574028821	0.017168862085872382 / 0.014332097218830869
77	PLAUR_2	19_43665377_C_A / 19_43665506_A_C	0.0004816822177162012 / 0.000329711238045009	0.013703989625456308 / 0.02821338934893095
78	UPP1_2	7_48108129_C_G / 7_48108147_T_G	0.0005053096271809359 / 0.032569834532674265	0.0002337913556195707 / 0.0015081620173450355
79	TM4SF1_3	3_149375338_T_G / 3_149375342_T_G / 3_149375345_A_G	0.0006450924297222392 / 0.00041880937510606033 / 0.0045963625050391855	0.00025288036755393063 / 0.005766354533635817 / 0.02993773631668
80	ZNF430_4	19_21020746_C_T / 19_21022725_C_T / 19_21034405_A_G / 19_21022773_T_G	0.0006475458714423392 / 0.0074498992574896375 / 0.001227492240630532 / 0.0008007999312255407	0.0014493947676260713 / 7.931044376997757e-06 / 0.043344266998276815 / 0.024171318376603662
81	CYTIP_2	2_157427544_C_T / 2_157427198_A_G	0.000837855207497095 / 0.004314698497827655	0.016967272956506692 / 0.0066627404504453576
82	FAM129B_3	9_127531490_GA_G / 9_127525143_T_G / 9_127578821_C_G	0.000922821517572468 / 0.0002411893320187629 / 8.276570085958934e-05	0.031013612085774283 / 0.010661251800502545 / 0.0009666899162254512
83	SEC11C_2	18_59152698_T_C / 18_59139887_T_G	0.0009260156067678403 / 0.049013482279269986	0.0022574597582570113 / 0.007830715004334495
84	SERPINB6_3	6_2955641_A_C / 6_2955644_A_C / 6_2959401_A_C	0.001043382693355795 / 0.024971781697072672 / 0.0010045092345408332	0.01355817950847752 / 0.003892754006925403 / 0.039976665559382514
85	HEXB_5	5_74696581_T_G / 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A / 5_74715716_T_TA	0.0011109425360834742 / 0.0004588063308077307 / 0.00032306189000466006 / 0.0012875359612772113 / 0.013801634858228495	0.0076182846696747 / 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071 / 0.008716125756790354
86	CHAF1A_5	19_4431899_C_T / 19_4442339_C_T / 19_4443049_T_C / 19_4422720_A_G / 19_4442532_T_C	0.0013371878989745694 / 4.704638650715319e-06 / 0.002601657035134123 / 0.00848724820837247 / 0.0008277326854784058	1.913287638550038e-06 / 2.142565869765625e-07 / 2.294297809586175e-06 / 0.024620616607439628 / 0.010330162535447171
87	DTNBP1_5	6_15522870_T_C / 6_15662701_T_G / 6_15524467_T_C / 6_15637909_C_A / 6_15651411_GA_G	0.00140727662017035 / 0.0007340285829190258 / 0.000563588210134313 / 0.0015365486679584585 / 0.012631556103580063	0.02838345350893315 / 0.001004314451212422 / 0.0038345211108275156 / 0.02038116210082405 / 0.0014349866138238813
88	NPC1_6	18_23533587_A_G / 18_23531466_TG_T / 18_23543332_G_GA / 18_23556539_A_C / 18_23551637_T_C / 18_23540944_CT_C	0.001437129484746987 / 7.150026947753571e-05 / 0.0029007221429512673 / 0.0002201554381797956 / 0.00283655966462793 / 0.003557570436749789	0.049542946772028126 / 0.03680603821841593 / 0.0011845211365567286 / 0.011218938268584914 / 0.00977392034448968 / 0.040822963170832685
89	DCK_2	4_71023678_G_A / 4_71023683_A_T	0.0025792753639569685 / 0.004519208391207111	0.0495745351142595 / 0.03292890320415958
90	MYOF_5	10_93402739_A_T / 10_93341723_C_T / 10_93456833_C_T / 10_93359764_G_A / 10_93379679_T_C	0.0031553117726987327 / 0.0003251886046767745 / 0.0012115888716542418 / 0.0011033881652818386 / 1.1152022033742226e-05	0.008275987890594253 / 1.0154009952651607e-05 / 4.5730649026336375e-05 / 0.04572104850464974 / 0.0006543495060757152
91	CNOT6L_4	4_77720488_T_G / 4_77819455_A_C / 4_77720486_A_G / 4_77726534_A_C	0.003413275456645043 / 0.004884718330098437 / 1.3017900050261066e-05 / 0.013675885143940456	0.00045440611666765506 / 0.0041059419980858354 / 0.003812687853894012 / 0.002323583718729919
92	SNX24_2	5_122845530_G_A / 5_123023772_TA_T	0.003825812212204896 / 0.005412166991196986	0.032851178784777335 / 0.010215103992736332
93	SQSTM1_4	5_179833153_C_T / 5_179833213_G_A / 5_179822433_T_C / 5_179832842_G_C	0.004089948495769615 / 0.007896407107059047 / 1.0391418374918043e-11 / 5.901642675392869e-07	0.014656854055438881 / 0.015290841042493631 / 0.0024949336391905503 / 0.0024314650981475784
94	CTTN_7	11_70419876_A_C / 11_70419880_T_C / 11_70433755_A_G / 11_70433765_G_C / 11_70407283_C_T / 11_70433037_T_G / 11_70435435_C_T	0.004793877560857165 / 0.0029267237988671235 / 0.0002662301400632249 / 2.1853977605406948e-05 / 5.710606729324503e-07 / 0.00010373335018763256 / 0.002764146814493288	0.00030309409522359497 / 0.003131141961303907 / 0.02047999046614251 / 0.008528354106314544 / 0.005941149857145408 / 0.004388396641544275 / 0.013709818259161087
95	KDM2B_4	12_121580903_A_C / 12_121579943_C_CA / 12_121444386_T_G / 12_121580252_TG_T	0.004804220239616889 / 5.298915204579247e-06 / 7.807472174797022e-08 / 0.024172279934987287	0.04290936139558865 / 0.01794421156168876 / 0.019501973878425127 / 0.004964292850525796
96	CTNNA1_4	5_138812304_T_G / 5_138824633_A_C / 5_138933920_C_T / 5_138812289_C_G	0.005041441550878414 / 0.009914746459480685 / 0.00032076772718977635 / 0.013542487211798218	0.013339032203366944 / 0.004284224604488671 / 0.00010488952235634391 / 0.0010251811268691103
97	TRIOBP_2	22_37751927_A_C / 22_37757383_C_G	0.0053165450762140245 / 0.0016386338499532257	0.008760146502383994 / 8.295724649894844e-05
98	EGR1_2	5_138467153_A_C / 5_138466811_A_C	0.005590395913285018 / 0.00018684738505679937	0.006707694887573882 / 0.00027393305226194143
99	MYCBP2_8	13_77070727_G_A / 13_77165156_A_T / 13_77098982_T_G / 13_77051091_G_A / 13_77051098_A_C / 13_77058230_T_G / 13_77061586_T_C / 13_77267898_T_G	0.008036895878308711 / 0.012181733375411912 / 0.0004449974043640469 / 0.0007742974469162077 / 0.004690941013903492 / 0.022811552981952272 / 0.0002327215378800939 / 0.004205585533754351	0.029852585169277374 / 0.00045980757332588846 / 0.0038229074053839733 / 0.00017518564876142542 / 4.397700485560215e-05 / 0.0032117224925540928 / 0.030373685856290068 / 0.00592396173483849
100	TCF4_6	18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55275664_A_G / 18_55403517_A_C / 18_55461237_G_T	0.008090959269238968 / 0.0056178520760126974 / 0.001559758175866868 / 0.012472558742737408 / 0.0011862271176169732 / 0.006912522905586032	0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 0.00619762753769391 / 1.5397131093463103e-06 / 0.04572000946513434
101	LAMC1_3	1_183132309_A_C / 1_183131203_C_T / 1_183131172_CAA_C	0.008181813089040216 / 3.4320876665108484e-05 / 0.02745630451997897	0.01655294869349123 / 0.03400723316751987 / 0.002417084109353407
102	DCBLD2_2	3_98800637_G_A / 3_98822022_G_A	0.00885632710582371 / 0.003195091628487625	0.02405283820151249 / 0.02321925017861924
103	FAM114A1_2	4_38905545_G_A / 4_38905553_A_G	0.008914101428030875 / 9.057397575383816e-05	0.004385515653682114 / 0.0017226027017899913
104	RXRA_2	9_134379472_C_A / 9_134432274_T_C	0.01212893284996885 / 0.0010613625702847742	0.008306707838893354 / 0.02628295923936911
105	TXNL4A_2	18_80033872_T_C / 18_79988525_A_C	0.013055851849266827 / 0.0007334523399616647	0.0008431735834914795 / 0.0008431735834914795
106	PLOD1_3	1_11957799_T_G / 1_11958607_A_C / 1_11949823_T_G	0.016423562694112787 / 0.0001256608005905079 / 0.00021455234639659347	0.008642421166450967 / 0.04289731210522306 / 0.033198246352540164
107	ZBTB40_2	1_22508509_T_G / 1_22490438_G_C	0.019306644087308318 / 0.0028404969140742	0.007412910007401148 / 0.034427044070664166
108	LAMB1_4	7_107937003_CT_C / 7_107937011_T_C / 7_107932321_G_T / 7_107962914_G_C	0.02001404015878396 / 0.03127808008490267 / 2.518001172595479e-05 / 0.001938778625683203	0.0036685711722291453 / 0.0056496711183904105 / 0.008417008915963444 / 0.03562871053322305
109	ZNF407_2	18_74635526_T_C / 18_74631665_A_C	0.02054827360868693 / 0.0027671214071800644	0.0030145474545959137 / 0.0007578348015755224
110	PLK2_2	5_58457156_TA_T / 5_58459186_CA_C	0.02678606136810066 / 0.011492772698233265	0.0067079016563832035 / 0.009712841903254471
111	ITGAV_6	2_186622542_G_T / 2_186637080_T_G / 2_186637084_A_G / 2_186602110_C_T / 2_186665096_ATTT_A / 2_186665096_ATTT_AT	0.02893229553935201 / 1.7690277512995773e-05 / 5.7650114136378393e-05 / 0.0008794014178128033 / 0.0009612996704148748 / 0.0001992070205841996	0.0007084667177580308 / 0.001139110475330106 / 0.032143834630956734 / 0.02901306245899837 / 0.02901306245899837 / 0.044847327779240435
112	TPP2_4	13_102649187_G_T / 13_102654868_C_T / 13_102663598_G_C / 13_102663763_G_A	0.03448812010250688 / 0.0477208297438401 / 0.019367023504440688 / 0.03879139461694567	0.0003388682906380855 / 0.0002674729630147893 / 5.0196213345567326e-05 / 0.0001694198597404117
113	EGFR_2	7_55205133_G_A / 7_55205662_A_C	0.03713506709789649 / 0.0018125796749231603	0.003745674667154008 / 0.0007797573368817686
114	FAM57A_2	17_733080_T_TCTC / 17_733026_A_AGGGCC	0.039798318296646464 / 0.015321230586696297	0.00016240672631849488 / 4.5958865963508443e-05
115	RBFOX1_2	16_7676807_A_C / 16_7653705_T_G	1.089283918433845e-06 / 0.009933638723622762	0.017746981967786752 / 0.040139058541755146
116	PLEC_10	8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143917234_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143925385_A_C / 8_143919088_C_G / 8_143927138_G_A / 8_143930	1.2060887811693293e-09 / 0.0045339553290741135 / 0.000104533588224814 / 1.7757593439950334e-05 / 0.00011641011921845986 / 1.9686417676937634e-05 / 0.006102754107095385 / 0.01695040934478527 / 0.039180192965724406 / 0.017591680187249745	0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 0.013279688389245713 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.0062995698781779215 / 0.009415988048366521 / 0.008162873576760793 / 0.001268625363946227
117	ACTN1_2	14_68904620_A_G / 14_68879945_C_A	2.2790061519900746e-05 / 0.002826959920374089	0.01924890787722053 / 0.03820518094606298
118	YES1_2	18_724697_A_C / 18_732727_A_G	2.3090624801719088e-05 / 0.007129044591559579	0.008883311549914912 / 0.026256278963938562
119	SMARCC1_2	3_47662444_T_G / 3_47735913_C_T	2.3383243293118917e-06 / 0.002421910157609216	0.0017680794934126945 / 0.01814701077813162
120	LMNA_2	1_156139242_AT_A / 1_156138783_A_G	2.3951192128687798e-05 / 0.0022551444971150103	0.04237931129547261 / 0.040758441980734486
121	CCND1_2	11_69650913_A_G / 11_69651969_C_G	2.86821845503723e-06 / 0.0004216841283241181	0.024298615321604846 / 0.021515769887785408
122	SMARCA4_3	19_11025539_C_G / 19_11025639_C_T / 19_11059900_G_C	3.0403566208171576e-05 / 9.60336281664007e-06 / 0.00028978302130045137	0.00029624992802644123 / 0.02706216606857304 / 0.035243495124704975
123	KMT2C_7	7_152273692_G_A / 7_152235860_C_T / 7_152145265_T_G / 7_152152848_C_A / 7_152177504_T_G / 7_152236218_G_A / 7_152152869_A_G	4.1091183934080156e-05 / 0.03814263508657298 / 0.010803753158495692 / 0.018128565763915704 / 0.001183790631102062 / 0.008327722660599219 / 0.017441444102837326	0.02044755694417402 / 0.00015664974968742393 / 0.0030671124260532785 / 0.00028670765106413883 / 0.0007976241891358237 / 0.0009326888762057726 / 0.008191480303636886
124	PXN_2	12_120219856_A_C / 12_120219864_A_C	4.578278108445838e-05 / 0.0074220837424624425	0.0003630643828121584 / 0.0023389819820739933
125	BCOR_2	X_40052275_A_C / X_40074609_T_G	4.939704915952993e-09 / 0.0027449638737320047	0.00020414397606395237 / 0.02744186131378764
126	FLI1_2	11_128810729_A_G / 11_128810736_G_C	5.306393173162265e-05 / 0.004212940238900314	1.6562593178924343e-05 / 1.4658089385344776e-05
127	LAMB2_4	3_49121431_A_C / 3_49126013_T_G / 3_49125146_T_G / 3_49121239_T_G	5.5170807525836925e-05 / 0.03902097870402451 / 7.419230761410297e-05 / 0.003164093062093864	2.9470349723526757e-05 / 0.002569958840604656 / 0.002569958840604656 / 0.028556312248339717
128	HMGA2_2	12_65841991_CT_C / 12_65838525_G_A	5.57550946086e-05 / 0.039914434884169736	0.032926686839147117 / 0.00575414262140414
129	ZNF708_3	19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A	5.694223127781568e-05 / 9.010844850080123e-06 / 0.0003481251422158083	0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05
130	ASPH_2	8_61578734_T_G / 8_61578968_A_C	6.56790692451237e-08 / 0.0009758798617439217	0.00027481062695969863 / 0.0029272870469332557
131	CCAR1_5	10_68737016_C_A / 10_68736998_A_C / 10_68747386_A_C / 10_68749170_A_C / 10_68747145_CT_C	8.229773536774104e-06 / 0.007146867657347806 / 0.0011117731660420908 / 0.0013852137674061765 / 0.003664158474067453	0.003954046326130957 / 0.005283569468845993 / 0.002868590533518923 / 0.044268019704288585 / 0.007417608363424872
132	DOCK1_3	10_127008567_ATAACT_A / 10_127248024_G_T / 10_127414990_T_G	9.077419985352092e-05 / 0.0002745710836507499 / 0.00705137247255559	0.0011610761862802675 / 0.020184142497530616 / 0.047170945666414485

Table 17 shows the biomarkers associated with EGRF drugs and the degree of reactivity (P-value) of the drugs by the tables.

In [Table 17], FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" means the correlation (P-vlaue) value of the corresponding marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified by the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 39, correlation values (P-vlaue) values of EGRF drugs of major biomarkers among the biomarkers described in [Table 17] are displayed in a graph.

Reactive biomarker for EGRF drug and verification result of reactivity with drug

No.	FRH	Variants	Var_Drug (pval)	Var_Exp (Pval)
One	CWC27_1	5_64977191_G_A	2.20E-08	0.002090721
2	RNF217_1	6_125082793_A_C	3.96E-08	0.0374208
3	PTGR1_1	9_111597344_C_A	8.25E-08	2.15E-05
4	NTN4_1	12_95738117_A_G	1.53E-07	0.019702457
5	ZNF276_1	16_89737928_T_C	1.72E-07	0.019670045
6	THBS1_1	15_39587486_A_C	2.59E-07	0.031233094
7	TRIM29_1	11_120115474_C_A	3.52E-07	0.011023929
8	APBB1_1	11_6401118_A_C	7.48E-07	0.04449344
9	RASA3_1	13_113981629_G_A	1.35E-06	0.009453296
10	TMX3_1	18_68700489_TA_T	1.39E-06	0.003224589
11	RRP1_1	21_43791417_C_A	1.65E-06	0.034182877
12	SIT1_1	9_35650461_G_A	1.75E-06	0.019947873
13	FRG1_1	4_189955114_T_C	2.25E-06	0.018901776
14	GTF2IRD1_1	7_74512993_A_G	3.54E-06	0.006481631
15	DCP1A_1	3_53342054_G_C	4.78E-06	0.003471409
16	SNRNP70_1	19_49101556_A_C	5.20E-06	0.016599779
17	DDX20_1	1_111756207_T_C	5.26E-06	0.008003234
18	TJP2_1	9_69237088_T_C	5.58E-06	0.04386431
19	RHOJ_1	14_63269236_T_G	6.18E-06	0.027885215
20	CXCL2_1	4_74098975_A_C	7.13E-06	0.000838562
21	CARD8_1	19_48212012_T_C	9.03E-06	0.00020501
22	TRMT2A_1	22_20117296_A_C	9.03E-06	0.048556634
23	CRIM1_1	2_36479368_G_C	9.53E-06	0.012444715
24	ELF3_1	1_202010991_C_G	9.65E-06	0.017391595
25	UHRF2_1	9_6482002_G_T	1.20E-05	0.007025127
26	HDHD2_1	18_47115026_C_T	1.42E-05	1.48E-06
27	ZBTB17_1	1_15944765_G_A	1.47E-05	0.010171388
28	THRB_1	3_24143504_G_A	1.80E-05	0.026515077
29	DHRS3_1	1_12568430_G_A	1.81E-05	0.043238329
30	AGTPBP1_1	9_85672687_TA_T	1.94E-05	0.017580094
31	DMTF1_1	7_87166631_TAG_T	1.97E-05	0.010040428
32	CTBP2_1	10_124993226_T_G	2.02E-05	0.022707139
33	BLK_1	8_11543171_G_A	2.24E-05	0.01145612
34	EPCAM_1	2_47373742_AT_A	2.57E-05	0.033377716
35	JUN_1	1_58782229_T_C	2.65E-05	0.037758558
36	RBM5_1	3_50114164_G_T	2.77E-05	0.00111984
37	CDKN2AIP_1	4_183445476_T_TGCACA	2.77E-05	0.002734488
38	ZCCHC7_1	9_37302158_C_T	2.93E-05	0.022389727
39	RAB8B_1	15_63262625_GTA_G	2.96E-05	0.020562837
40	ODC1_1	2_10444350_A_C	2.98E-05	0.031377929
41	CLTB_1	5_176397682_T_C	3.11E-05	0.006127908
42	UIMC1_1	5_176906125_C_T	3.66E-05	0.014840456
43	HCST_1	19_35903545_A_C	3.71E-05	0.031562304
44	HSPA1B_1	6_31828722_C_G	3.82E-05	0.018774385
45	MYL12B_1	18_3261766_G_T	4.16E-05	0.002628021
46	RHBDF1_1	16_63885_G_GCC	4.21E-05	0.04101508
47	UBE2N_1	12_93411182_C_T	4.29E-05	1.51E-06
48	SVIL_1	10_29524582_A_G	4.44E-05	0.010981597
49	CCDC28B_1	1_32202026_A_C	4.45E-05	0.031117706
50	ADARB1_1	21_45182568_CT_C	4.48E-05	0.049945862
51	PPP4R1_1	18_9549876_A_G	5.09E-05	0.004893788
52	CHD1L_1	1_147294440_C_G	5.10E-05	0.048656291
53	LRP5_1	11_68424878_T_G	5.20E-05	0.010363624
54	RND3_1	2_150487464_GA_G	5.77E-05	0.009852344
55	LONRF1_1	8_12731670_C_A	5.98E-05	0.001411904
56	BCOR_1	X_40052275_A_C	6.09E-05	0.000204144
57	CCT8_1	21_29070160_C_T	6.54E-05	0.02571665
58	ZNF330_1	4_141232702_CTT_C	8.61E-05	0.012329326
59	CEP128_1	14_80916501_C_A	8.82E-05	0.001156052
60	SH2D3A_1	19_6760997_A_G	9.99E-05	0.028745239
61	IRF6_1	1_209790735_C_T	0.000103095	0.008136801
62	ITGAL_1	16_30484175_C_T	0.000109049	0.037227837
63	UEVLD_1	11_18558312_C_A	0.000112934	0.026771319
64	RNF141_1	11_10530725_T_C	0.000116417	0.011923468
65	THRAP3_1	1_36288866_G_C	0.000117571	0.000131738
66	PIAS4_1	19_4028785_C_T	0.000120052	0.024864531
67	SLC22A5_1	5_132390655_C_A	0.000123083	0.004292176
68	JAG1_1	20_10648877_T_C	0.00012714	0.02148436
69	SPI1_1	11_47358510_A_C	0.000133865	0.03491009
70	TECPR1_1	7_98223587_A_G	0.000136841	0.023100583
71	ZC3HC1_1	7_130023656_C_T	0.000136956	0.010175357
72	PDGFA_1	7_518698_G_C	0.000139135	0.000252407
73	C16orf74_1	16_85741569_G_A	0.000148491	0.001823033
74	DOT1L_1	19_2226677_G_A	0.00015451	0.006191812
75	CD19_1	16_28937656_A_C	0.000155088	0.031114669
76	P2RY2_1	11_73235099_G_C	0.000158117	0.045669577
77	EHF_1	11_34661000_T_C	0.000158117	0.017992198
78	EPS15L1_1	19_16392488_A_C	0.000158117	0.033272384
79	AGTRAP_1	1_11750007_T_G	0.000159275	0.049159238
80	LYRM7_1	5_131199511_CT_C	0.000164473	0.021278948
81	EPAS1_1	2_46346944_T_G	0.000170063	0.018667654
82	SIX4_1	14_60713618_C_T	0.000180476	0.049844478
83	PROM2_1	2_95281185_T_G	0.000190311	0.033838771
84	CAPN1_1	11_65186241_T_G	0.000194914	0.02936405
85	SRRM1_1	1_24669380_C_A	0.000202713	0.019718891
86	KLF3_1	4_38689006_A_C	0.000228896	0.015121455
87	THSD4_1	15_71765130_A_C	0.000239788	1.95E-06
88	GPR107_1	9_130129853_A_G	0.000243505	0.033022802
89	TCERG1_1	5_146471685_A_C	0.000246294	0.042046343
90	ATG4C_1	1_62805167_G_T	0.000259178	0.028589986
91	SHQ1_1	3_72750552_C_T	0.000259737	0.005940284
92	DSG2_1	18_31524751_A_G	0.000261765	0.009944093
93	S100A14_1	1_153615226_C_T	0.000274681	0.01787459
94	CLDN4_1	7_73830773_C_T	0.000293995	0.000682466
95	OVOL2_1	20_18041767_A_G	0.000295117	0.047118131
96	CREB1_1	2_207577759_AT_A	0.00029854	0.000463006
97	BCLAF1_1	6_136278266_T_C	0.000301864	6.60E-05
98	PKP2_1	12_32791480_G_T	0.000343509	0.006486331
99	ADAM9_1	8_39082624_ATTT_A	0.000344695	0.022961
100	POLA1_1	X_24743203_T_G	0.000351661	0.028975018
101	FBXO10_1	9_37537560_G_A	0.000376887	0.024540631
102	CHMP4B_1	20_33811394_C_G	0.000388769	0.00409862
103	NOP56_1	20_2657708_GT_G	0.000405654	0.000313483
104	WIPF1_1	2_174585550_T_G	0.000407518	0.000483959
105	SCNN1A_1	12_6349108_G_C	0.00042455	0.003465155
106	C11orf80_1	11_66828178_C_T	0.000427492	0.010017428
107	ERP27_1	12_14914577_T_TGTGC	0.000433389	0.018734323
108	JAG2_1	14_105151295_T_G	0.000452695	0.00756224
109	SMARCC1_1	3_47693210_A_G	0.00046021	6.92E-05
110	RNF138_1	18_32123591_T_C	0.000469129	0.018606829
111	THYN1_1	11_134248640_G_T	0.000477172	0.042214253
112	CYP24A1_1	20_54164725_T_C	0.000480706	0.013922674
113	SH2D3C_1	9_127766923_A_C	0.000489816	0.042455713
114	TGFA_1	2_70453242_T_G	0.000497539	0.011508647
115	CXCL16_1	17_4738773_T_G	0.000507631	0.000457547
116	AEN_1	15_88629905_A_C	0.000523617	0.014580971
117	SLC37A1_1	21_42534616_T_G	0.00054592	0.025393921
118	EPHA2_1	1_16148437_A_C	0.000564393	0.003022958
119	BCS1L_1	2_218660859_A_G	0.000567546	0.011564609
120	FBXO43_1	8_100137711_G_C	0.000602338	0.026281824
121	ADAM22_1	7_88075657_C_T	0.000632153	0.041287227
122	ADAMTSL1_1	9_18636052_G_T	0.000649915	0.010200615
123	ATXN2L_1	16_28834263_C_T	0.000652099	0.023519932
124	ZCCHC4_1	4_25313024_A_C	0.000669769	0.022993547
125	BCL2_1	18_63318646_T_C	0.000676626	0.021320439
126	EGR1_1	5_138466811_A_C	0.000686817	0.000273933
127	HS3ST1_1	4_11399218_T_C	0.000704542	0.027639734
128	LEF1_1	4_108078210_G_A	0.000716837	0.012727304
129	SRSF7_1	2_38748190_GT_G	0.000734347	0.005863144
130	KHSRP_1	19_6415784_T_C	0.000787917	0.003576751
131	YPEL1_1	22_21704297_T_C	0.000796764	0.006311112
132	TAPT1_1	4_16162866_G_A	0.000802167	0.000763967
133	SNRK_1	3_43348277_C_T	0.000817875	0.00952899
134	UGCG_1	9_111932206_A_G	0.000846657	0.012775358
135	DBF4B_1	17_44709262_G_C	0.000856709	0.025236345
136	HOOK1_1	1_59860373_C_G	0.000856894	0.041888498
137	ITGB3BP_1	1_63572436_G_T	0.000871324	0.023830002
138	DTX4_1	11_59205028_T_C	0.000886385	0.025332013
139	PPP1R13L_1	19_45391868_T_C	0.000894105	0.005877508
140	CBLC_1	19_44790103_A_C	0.000937082	0.025305244
141	B4GALT4_1	3_119212822_G_T	0.000987069	8.97E-06
142	HSBP1_1	16_83809462_C_T	0.000990234	0.008673739
143	DTX1_1	12_113093500_A_T	0.001029524	0.02107386
144	TMEM51_1	1_15219789_A_C	0.001061315	0.004570596
145	ASAP2_1	2_9388476_A_C	0.001065564	0.013740425
146	PPP2R3C_1	14_35096667_C_A	0.001070573	0.008848084
147	WWC2_1	4_183280995_G_T	0.001131955	0.017164588
148	DMKN_1	19_35505819_C_T	0.001187435	0.023762682
149	EPHX1_1	1_225838589_T_G	0.001193048	0.015600736
150	PRPF4B_1	6_4051933_C_A	0.001231599	0.023843897
151	SNRNP40_1	1_31267793_A_G	0.001239539	0.0334327
152	LTBP3_1	11_65543062_T_C	0.00124246	0.027887632
153	BAG3_1	10_119651803_A_C	0.001254787	0.031179453
154	ANKRD2_1	10_97572685_T_G	0.001261251	0.014732168
155	ZNF451_1	6_57147971_C_A	0.001263762	0.000340137
156	ME2_1	18_50920583_C_T	0.00130336	2.53E-06
157	DLG5_1	10_77811963_T_G	0.001305738	0.016910687
158	USP19_1	3_49111457_T_C	0.001383111	0.008511689
159	PDCD11_1	10_103433899_A_G	0.001419074	0.023046171
160	PDE1B_1	12_54577030_T_G	0.0014774	0.000907902
161	LONP1_1	19_5707040_C_G	0.001478061	0.014919269
162	KCNN3_1	1_154733143_A_C	0.001483801	0.012755172
163	FSD1_1	19_4304543_G_C	0.001495716	0.036857163
164	F2RL1_1	5_76832874_T_G	0.001535054	0.000269192
165	XPO4_1	13_20787374_T_C	0.001546207	0.044182604
166	TM4SF1_1	3_149375342_T_G	0.001551483	0.005766355
167	NPAS1_1	19_47035965_T_G	0.001567313	0.037858765
168	FAM78A_1	9_131260861_G_A	0.001574494	0.029873205
169	SYTL2_1	11_85734802_A_C	0.001576085	0.007792297
170	TMEM57_1	1_25431052_T_G	0.001577095	0.001041181
171	TUBA1A_1	12_49186397_T_C	0.001584541	0.019746043
172	ITPR3_1	6_33692820_C_T	0.001625448	0.001333145
173	ATM_1	11_108317650_T_C	0.001633198	0.007926126
174	SGTA_1	19_2769109_A_C	0.001653712	0.041785185
175	LCORL_1	4_17883673_A_AAC	0.001662772	0.000314326
176	MTDH_1	8_97660911_G_GATA	0.001694886	0.048360283
177	IKBKB_1	8_42320656_T_C	0.00170984	2.52E-05
178	HNRNPD_1	4_82355277_C_CA	0.001737277	0.049911299
179	RAX_1	18_59272671_A_C	0.001739655	0.028250861
180	ZNF775_1	7_150397902_A_C	0.001751147	0.01910485
181	ALDH1A3_1	15_100885169_T_G	0.001758148	0.04003907
182	GNAI2_1	3_50252193_A_C	0.001785905	0.005183043
183	ZNF740_1	12_53187645_C_G	0.001788461	0.049202233
184	NTM_1	11_132307846_G_T	0.001796239	0.000193861
185	CHN1_1	2_174801578_A_G	0.001797358	0.038050415
186	PAX5_1	9_36923611_G_A	0.001934236	0.014759026
187	VAMP3_1	1_7781489_A_C	0.00200626	0.040313352
188	STK4_1	20_44995009_C_T	0.002049488	5.24E-05
189	USP24_1	1_55075675_C_A	0.002073268	0.008980628
190	EXOSC10_1	1_11080567_C_A	0.002083377	0.019692529
191	TINAGL1_1	1_31585380_T_G	0.002085646	0.037138102
192	SPTLC3_1	20_13093456_G_T	0.002145546	0.024467108
193	PLEKHA6_1	1_204257921_A_C	0.002162143	0.049362899
194	PLXNC1_1	12_94219931_T_G	0.002163508	0.043558201
195	CAPN2_1	1_223717830_G_A	0.0022465	0.020893773
196	TJP1_1	15_29718124_TA_T	0.002277416	0.026903818
197	ASPHD2_1	22_26442326_G_A	0.002296851	0.029916144
198	IFT43_1	14_76082206_T_G	0.002305612	0.012552105
199	CASK_1	X_41578463_T_G	0.002309184	0.043343775
200	C21orf33_1	21_44144829_C_T	0.002316139	0.047114252
201	AFAP1L2_1	10_114294856_CCTAA_C	0.00232372	0.037962739
202	MEI1_1	22_41699656_A_C	0.002354824	0.019192604
203	HAUS6_1	9_19080551_G_A	0.002357763	0.027262757
204	LRRC8E_1	19_7899842_G_A	0.002381607	0.011668019
205	SMARCB1_1	22_23787366_GGC_G	0.002396307	0.000127894
206	DUT_1	15_48332272_A_C	0.002405318	0.00018263
207	MON1A_1	3_49911902_A_G	0.002439566	0.010543368
208	SASH1_1	6_148440274_CT_C	0.002448515	0.046157021
209	MAP1S_1	19_17726640_A_C	0.002527497	0.022464441
210	TOE1_1	1_45340381_G_A	0.002528538	0.048016234
211	CNOT7_1	8_17242848_C_T	0.002530932	7.40E-11
212	CD244_1	1_160836124_G_A	0.002583957	0.026316972
213	EPM2AIP1_1	3_36992730_A_C	0.002610713	0.00113706
214	PRSS16_1	6_27249457_C_T	0.002649855	0.041003068
215	GPSM3_1	6_32192179_T_C	0.002655487	0.017253689
216	UGDH_1	4_39527132_G_A	0.002672816	0.035973223
217	AIG1_1	6_143060973_T_C	0.002697343	0.001184612
218	PMS1_1	2_189864380_G_A	0.002709035	0.028805775
219	PTGFR_1	1_78497752_G_A	0.002814073	0.008690688
220	AGPAT2_1	9_136674614_A_G	0.002858165	0.022967509
221	CBL_1	11_119278299_T_G	0.002995636	0.015544213
222	RAB37_1	17_74694690_G_A	0.003050869	0.017656336
223	GTPBP3_1	19_17338111_A_C	0.003059974	0.000709713
224	HDAC4_1	2_239053232_A_C	0.003067942	0.036469606
225	MBD3_1	19_1577118_C_T	0.003069952	0.001822739
226	CEP170_1	1_243164906_G_A	0.003157617	0.005533907
227	S100A16_1	1_153607964_A_G	0.003160582	0.026054854
228	DCK_1	4_71022615_CT_C	0.003222902	0.021365647
229	INF2_1	14_104713013_A_C	0.003224544	0.022440089
230	MYO6_1	6_75870526_T_C	0.003249199	0.022167818
231	CDS1_1	4_84635369_T_A	0.003299427	0.032630939
232	CTDSPL_1	3_37980672_C_T	0.003333659	0.043268165
233	EPB41L1_1	20_36187855_G_T	0.003410098	0.042407864
234	FGR_1	1_27617489_T_A	0.003443717	0.014581374
235	CAPRIN1_1	11_34051813_A_G	0.003553009	0.001206062
236	FOXC1_1	6_1612184_TA_T	0.00358795	0.004712911
237	ARHGEF6_1	X_136685627_G_A	0.003598733	0.001837929
238	BCAR3_1	1_93674923_G_C	0.003606528	0.049870881
239	BCL9L_1	11_118897861_A_C	0.003681075	0.034238861
240	TMEM201_1	1_9610425_T_A	0.003707837	0.025977963
241	RPS11_1	19_49496985_C_T	0.003720736	0.048243831
242	GMEB1_1	1_28690201_G_T	0.003734863	0.005247117
243	XRCC5_1	2_216109182_G_C	0.00380529	0.019360584
244	IL13RA1_1	X_118776541_G_T	0.003874528	0.009303333
245	PRR14_1	16_30651924_T_G	0.003882844	0.041861928
246	SH2B3_1	12_111418260_C_G	0.003991404	0.00753988
247	DTNBP1_1	6_15662698_A_G	0.00400197	0.006306033
248	PADI1_1	1_17228910_T_G	0.004006843	0.013302935
249	FAF1_1	1_50787989_A_G	0.004030148	0.030848308
250	RAB11FIP5_1	2_73075763_G_GGCCT	0.004085081	0.024778824
251	ZBTB40_1	1_22508509_T_G	0.004115308	0.00741291
252	BLCAP_1	20_37517746_T_C	0.004121218	0.011965638
253	KIF2A_1	5_62373627_T_G	0.004150384	0.036674489
254	HCFC1_1	X_153963207_T_G	0.004154957	0.001579155
255	HINFP_1	11_119121467_T_C	0.004250524	0.04539997
256	PRDM2_1	1_13823349_T_A	0.004303676	0.011003429
257	EIF4E_1	4_98902074_AT_A	0.004333629	0.008214508
258	PARVG_1	22_44206294_C_G	0.004424	0.028583204
259	COX18_1	4_73064835_G_A	0.004489575	0.009081073
260	WDR33_1	2_127701640_C_G	0.004497758	0.006721664
261	ARHGAP9_1	12_57474460_G_A	0.004523019	0.041357487
262	GGCX_1	2_85550432_A_G	0.004614743	0.015128917
263	ZNF182_1	X_47983350_T_G	0.004661316	0.045101518
264	ANXA6_1	5_151117292_C_T	0.004727288	0.038173193
265	RPL14_1	3_40457950_G_A	0.004955666	0.001218496
266	FCHO2_1	5_73082876_ATT_A	0.004962427	0.029256929
267	RAB28_1	4_13473790_TATC_T	0.004968595	0.040901005
268	RNGTT_1	6_88769645_C_T	0.00502562	0.002545266
269	NNT_1	5_43602611_T_C	0.005081886	0.030151517
270	CLDN1_1	3_190308594_C_T	0.005105908	0.019956392
271	NRN1_1	6_6003752_C_T	0.005133833	0.006175355
272	ZNF423_1	16_49635837_A_C	0.005155281	0.015077717
273	YES1_1	18_732727_A_G	0.00519113	0.026256279
274	RAPGEF6_1	5_131433731_GA_G	0.005213959	0.0053626
275	MGAT4B_1	5_179799918_A_G	0.005262946	0.044186289
276	GATAD2B_1	1_153818250_T_C	0.005279052	0.026743921
277	FCRL5_1	1_157518564_T_C	0.005397526	0.023539142
278	ACSS2_1	20_34925819_A_C	0.00560253	0.016776881
279	CTR9_1	11_10773884_CAAAAA_C	0.005625384	0.03664895
280	INPP5B_1	1_37872885_G_T	0.005738649	0.010365859
281	RPAIN_1	17_5421266_TTC_T	0.005740177	0.041469888
282	RCHY1_1	4_75509142_T_A	0.00575286	7.00E-06
283	RASSF7_1	11_562335_A_C	0.005935904	0.018138357
284	NKX3-2_1	4_13541263_A_G	0.00596504	0.000419444
285	IGFBP3_1	7_45917562_GT_G	0.006141827	0.045400401
286	LTBR_1	12_6385217_T_C	0.006192879	9.81E-05
287	GNG2_1	14_51950694_A_C	0.006226032	0.02637487
288	NAP1L1_1	12_76084896_T_C	0.006264126	0.018182577
289	GULP1_1	2_188589974_C_CT	0.006362476	0.004507263
290	PXDC1_1	6_3727577_C_G	0.006364895	0.027367829
291	WDR12_1	2_202897546_T_A	0.006402216	0.044170968
292	TMBIM6_1	12_49742405_G_A	0.006435087	0.019471463
293	PPM1D_1	17_60656452_CA_C	0.006580355	0.01692061
294	RPA2_1	1_27907061_GA_G	0.006586873	0.02798096
295	PRR3_1	6_30562126_T_G	0.006592704	0.005676599
296	RBM28_1	7_128310614_C_A	0.006924451	0.019795754
297	ENAH_1	1_225519569_GAAAA_G	0.007036997	0.048924277
298	KIAA0922_1	4_153592379_A_G	0.0070597	0.048688528
299	TRIM2_1	4_153276097_A_G	0.007183471	0.011894098
300	ATP8B1_1	18_57731374_T_C	0.007320467	0.035819404
301	QSOX1_1	1_180178802_A_G	0.007420273	0.008203943
302	MB_1	22_35607296_C_G	0.007592955	0.045421658
303	ORAI2_1	7_102433548_G_A	0.007786599	0.035889292
304	WNT7B_1	22_45931386_G_A	0.007831858	0.025701725
305	PIKFYVE_1	2_208330748_GT_G	0.007852983	0.009816454
306	ARHGAP32_1	11_128972609_T_G	0.007895267	0.007875634
307	SH3YL1_1	2_249571_C_T	0.007939764	0.043096755
308	DEPDC5_1	22_31843912_CT_C	0.00801665	0.025230811
309	VSIG10_1	12_118073908_T_G	0.008024404	0.001976122
310	SLX4_1	16_3595722_A_C	0.008031231	0.013087513
311	REEP3_1	10_63621980_A_G	0.008035335	0.03021965
312	FARSB_1	2_222571709_T_C	0.00812224	0.037339824
313	NDUFS3_1	11_47578800_A_G	0.00843631	0.008511324
314	HIBADH_1	7_27538786_G_A	0.008437431	0.025866827
315	SCLT1_1	4_128957191_A_C	0.008485976	0.015508556
316	SLC20A2_1	8_42439475_C_T	0.008560526	0.001296999
317	LMO7_1	13_75855483_C_A	0.008616687	0.000790188
318	SREBF2_1	22_41897136_G_C	0.008665061	0.031235978
319	SPAG1_1	8_100194395_C_A	0.008766072	0.025833604
320	NCAM1_1	11_113270137_A_G	0.008796809	0.040540565
321	ATP1B1_1	1_169111407_C_G	0.008822814	0.015890801
322	PLXNB2_1	22_50281752_C_G	0.008850507	0.048268974
323	PFAS_1	17_8269414_A_G	0.008856682	0.026137416
324	CEP152_1	15_48762574_G_C	0.008866418	0.044026406
325	GNRH1_1	8_25423267_A_G	0.009056061	0.039449902
326	CARD10_1	22_37508612_T_C	0.009110799	0.021324272
327	COL6A3_1	2_237351090_T_G	0.00914922	0.009459532
328	RBM12B_1	8_93733158_G_T	0.009183374	0.012443278
329	ITPKC_1	19_40737666_A_C	0.009205546	0.045257656
330	ARHGAP31_1	3_119390922_C_T	0.009221747	0.042725387
331	GRAMD1A_1	19_35022992_C_T	0.00930255	0.030347265
332	SAE1_1	19_47131056_T_G	0.009443122	0.006083296
333	MICALL1_1	22_37924607_T_G	0.009460572	0.025017274
334	GABRB2_1	5_161336809_G_A	0.009484795	0.019276169
335	SPINT2_1	19_38287977_A_G	0.009500965	0.018521267
336	ATXN7_1	3_63990247_A_C	0.009623217	5.97E-05
337	TATDN2_1	3_10248824_C_CT	0.009659313	0.000116552
338	AP4E1_1	15_50968319_T_G	0.009752147	0.046599506
339	CHST2_1	3_143121243_A_G	0.009892538	0.040099833
340	PRKAG2_1	7_151560579_A_G	0.009896448	0.024618763
341	C16orf45_1	16_15596596_T_G	0.009927037	0.04351851
342	SULT2B1_1	19_48591514_T_G	0.009943382	0.006727275
343	DSTN_1	20_17600864_A_G	0.009947784	0.000427203
344	TPD52L2_1	20_63889961_A_C	0.010191021	0.005896198
345	E2F2_1	1_23521217_C_G	0.010495212	0.008957912
346	TSEN34_1	19_54192354_T_G	0.010854598	0.001848481
347	FOXN3_1	14_89162512_A_C	0.011014558	0.001249668
348	MND1_1	4_153408912_G_GTATATA	0.011263008	0.006400349
349	ZDHHC5_1	11_57696028_T_C	0.01129582	0.000204877
350	ARMCX4_1	X_101488321_C_G	0.011422104	0.008157752
351	P2RY11_1	19_10115376_G_A	0.011466091	0.000105991
352	C1orf198_1	1_230839028_T_C	0.011890625	0.008759206
353	TPTE2_1	13_19425773_G_A	0.011929579	0.00812417
354	TMEM206_1	1_212379769_G_C	0.01195192	0.000739419
355	REEP5_1	5_112891583_T_A	0.012573055	0.001996089
356	CNNM4_1	2_96798981_T_G	0.012933399	0.000393837
357	GPR65_1	14_88011069_C_T	0.013002947	0.005376071
358	ZDHHC7_1	16_84981848_T_G	0.013133304	0.007398316
359	KCNAB3_1	17_7925552_G_A	0.013376003	0.008474756
360	ASNSD1_1	2_189670812_C_T	0.013663903	0.004106264
361	LY9_1	1_160814485_A_C	0.014209114	0.004017681
362	SKIV2L2_1	5_55307994_T_C	0.01489715	0.008290134
363	MADD_1	11_47325027_T_C	0.01504914	0.001497343
364	ITPRIPL1_1	2_96325641_T_G	0.0151793	0.004828474
365	SDC4_1	20_45330303_T_G	0.015973482	0.000496261
366	SLC2A8_1	9_127398490_G_A	0.016168742	0.003968261
367	CSF2RB_1	22_36923285_A_C	0.016450302	0.008060727
368	WWTR1_1	3_149669685_C_T	0.016674011	0.040303211
369	PEX10_1	1_2410431_A_C	0.017756279	7.19E-05
370	SCMH1_1	1_41033845_T_G	0.01786284	0.006455807
371	WNT10A_1	2_218882471_A_C	0.018148757	0.008633339
372	SIRT4_1	12_120303510_G_GAA	0.018478224	0.002426212
373	SLC25A43_1	X_119451980_A_G	0.018546868	0.000927303
374	SLC35F5_1	2_113723196_TA_T	0.019332514	0.009792442
375	PLEKHA5_1	12_19369550_A_AAAAG	0.019740309	0.004535622
376	RASEF_1	9_82982805_CAGAG_C	0.019798987	5.81E-06
377	RASSF2_1	20_4797919_T_G	0.019937429	0.007153311
378	ANKRD44_1	2_197099965_G_A	0.020081182	0.009634061
379	ZFYVE19_1	15_40812591_A_AAG	0.020142634	0.000177529
380	TMEM2_1	9_71704688_T_G	0.02064031	0.00528138
381	TMEM159_1	16_21174063_G_A	0.020994925	0.001734513
382	PEX13_1	2_61045783_A_T	0.021004523	0.005293964
383	BCAR1_1	16_75229126_T_A	0.021029307	0.004775721
384	SLC25A38_1	3_39389590_G_A	0.021402491	5.21E-05
385	ING5_1	2_241711916_A_C	0.021779734	0.000297693
386	AHR_1	7_17339074_A_C	0.021825994	0.009928124
387	ETV1_1	7_13900838_A_C	0.022234699	0.00028392
388	FUS_1	16_31191353_T_G	0.022580325	0.000527105
389	ELMO1_1	7_36986095_A_C	0.022675843	0.000582138
390	FLI1_1	11_128772826_T_G	0.022696029	2.10E-08
391	RBPJ_1	4_26321137_C_A	0.023026755	0.005948758
392	TGM1_1	14_24260894_A_C	0.023877255	4.06E-05
393	MAD2L2_1	1_11680485_C_A	0.024343193	0.005401081
394	CCDC66_1	3_56613771_T_C	0.024734355	0.00694013
395	E2F3_1	6_20402547_A_C	0.024779926	0.001096854
396	TRIM47_1	17_75875198_A_C	0.025043777	0.006990418
397	LACTB2_1	8_70657773_A_C	0.025193805	0.000265188
398	S100A13_1	1_153619154_A_C	0.026872567	0.000285894
399	PRKCZ_1	1_2059508_T_G	0.027355157	0.000553783
400	KIAA0430_1	16_15601202_A_G	0.027767771	0.008344755
401	PARP1_1	1_226377365_T_C	0.028078591	0.000660394
402	VMP1_1	17_59841357_A_C	0.028144116	0.00700708
403	TRPM7_1	15_50619668_AT_A	0.028234282	0.007696192
404	RPL11_1	1_23695353_C_A	0.028842665	0.006999268
405	RHPN2_1	19_33002924_G_A	0.02894401	0.001694408
406	MAST3_1	19_18107675_A_T	0.028979003	0.002887665
407	SACS_1	13_23354711_A_C	0.029483838	0.007436264
408	ZBTB4_1	17_7463332_C_G	0.030579241	0.009123992
409	SSH3_1	11_67309455_A_C	0.031167208	0.006068708
410	STAU1_1	20_49153934_T_C	0.031695969	0.047157357
411	PRSS22_1	16_2853046_G_C	0.032478102	0.003660773
412	SRRD_1	22_26488073_G_A	0.03313164	0.001986837
413	ITGB8_1	7_20399120_C_G	0.033295835	0.000193939
414	FLII_1	17_18245630_C_G	0.033989678	0.00994433
415	TMEM40_1	3_12769284_C_T	0.034416268	0.003842868
416	SLC19A1_1	21_45512453_A_C	0.034642487	0.009916208
417	FBN1_1	15_48425289_G_T	0.035154355	0.007224526
418	TMC4_1	19_54160564_G_A	0.03557474	0.008695606
419	TACC2_1	10_122132454_G_A	0.036645036	7.09E-05
420	HEATR5A_1	14_31315848_T_C	0.037815962	0.000583004
421	SLC25A24_1	1_108161212_C_T	0.038139179	0.001625377
422	TMEM39B_1	1_32091713_A_C	0.038513492	0.008701631
423	ANKRD22_1	10_88831974_A_C	0.039475145	0.00796284
424	SFSWAP_1	12_131753058_C_G	0.039748632	0.004289964
425	C1orf54_1	1_150279750_G_C	0.039956255	0.001281485
426	SEPT10_1	2_109564377_G_T	0.040053757	0.00487648
427	FOS_1	14_75280999_A_C	0.04011469	0.001488063
428	AARS2_1	6_44301927_CAGG_C	0.041166243	0.004966986
429	EMP1_1	12_13211531_T_G	0.041461108	0.001600571
430	FBXO2_1	1_11648995_C_G	0.042445462	0.005932397
431	UBE3A_1	15_25408653_C_A	0.044428109	0.002080316
432	GPC1_1	2_240451007_T_G	0.044965723	0.007919222
433	ACTN4_1	19_38728028_T_G	0.045229843	0.005408687
434	EPB41L4B_1	9_109182980_T_C	0.045378555	0.002429073
435	SERTAD3_1	19_40441466_GGATC_G	0.045415799	0.001465832
436	WHSC1L1_1	8_38315857_G_C	0.046096872	0.004506209
437	QRICH1_1	3_49076524_TAAA_T	0.046339149	0.007356338
438	CAMSAP3_1	19_7618018_A_C	0.046801001	0.000416732
439	TCHP_1	12_109907472_T_G	0.047094137	0.003720466
440	TUFT1_1	1_151565936_G_A	0.048675231	0.004559558
441	CHMP1A_1	16_89649256_C_T	0.048695701	0.003804631
442	LAMB2_1	3_49125146_T_G	0.049754671	0.002569959
443	PNRC2_1	1_23961290_GCTT_G	0.049756672	0.006024417
444	MARVELD2_1	5_69419733_A_C	0.049786079	0.007668831
445	SLC22A18_3	11_2919250_T_G / 11_2903361_G_A / 11_2919268_T_G	0.00010006113410040524 / 0.0011537278855378685 / 0.03948380156101269	0.003253241739951185 / 0.009485355002003664 / 0.004588734004408302
446	SH3D19_3	4_151148254_TACACACACACACACAC_T / 4_151122202_T_C / 4_151148202_G_T	0.00010065962678441032 / 0.015768562077467373 / 0.0009087951468125592	0.016052772944150497 / 0.00026537095134489047 / 0.004030165987762314
447	LARS2_5	3_45474156_T_C / 3_45476267_G_A / 3_45488909_G_A / 3_45500591_T_C / 3_45417241_A_G	0.00010374784857743111 / 3.7424426310272928e-06 / 1.2434210249182578e-07 / 6.432927229497336e-08 / 0.004689576487598519	1.1453239774161183e-13 / 9.671821420877082e-13 / 6.257680298053254e-14 / 4.345853387032865e-14 / 0.022164736928693304
448	SRGAP1_2	12_64142411_T_C / 12_64097222_GTT_G	0.00010959539878441124 / 0.0011886231256692465	0.006505852651723906 / 0.02613509690642953
449	ALDH3A1_3	17_19742310_G_A / 17_19748298_C_T / 17_19740913_C_G	0.00011241479007533596 / 0.0023838380538555946 / 0.026511359318080838	0.016065461057378518 / 0.04852415829065191 / 0.0007153928676742558
450	LPIN3_5	20_41345676_A_G / 20_41358461_T_G / 20_41358465_C_G / 20_41340873_C_A / 20_41350009_T_G	0.00011710984250539265 / 0.000846270947552816 / 0.0063262440202536815 / 7.192100726008128e-05 / 0.033798727519866234	0.001902884670314011 / 5.712471333190794e-05 / 6.891802498643105e-05 / 0.025739865299148755 / 0.0036707505113827256
451	LAMB3_3	1_209626885_C_T / 1_209626996_C_T / 1_209630438_C_T	0.00012286163323842149 / 0.0001560650413956853 / 0.00010264198687506551	0.014463355479842403 / 0.005725629984184445 / 0.0254414675884508
452	RAC1_2	7_6398689_A_C / 7_6401802_T_G	0.00012312607987750062 / 0.022378677686989437	0.0005959472772163739 / 0.003141262984465143
453	CERKL_2	2_181603835_A_C / 2_181678048_T_G	0.00012332912254087272 / 0.00048702996607960313	8.976196985876391e-05 / 0.010552400468127526
454	MTO1_2	6_73492090_C_T / 6_73473277_C_CAGAT	0.0001242869571724915 / 0.027975699490295474	0.0009500421967262693 / 0.0034299441619718607
455	SUMF1_2	3_4419885_G_A / 3_3846683_A_C	0.00013129129316308624 / 0.007888292383663753	0.017506933739797337 / 0.0026519652256760252
456	WDFY4_5	10_48946696_T_C / 10_48774557_A_C / 10_48823427_C_T / 10_48826590_T_A / 10_48709976_C_T	0.00014298234740370438 / 7.877438075749654e-06 / 0.006750199117687904 / 0.008731995024502738 / 0.0057882693531272345	0.03553981554074815 / 0.02592605078891659 / 0.041159506689191376 / 0.03934434383747865 / 0.036092320181802036
457	DSC2_3	18_31091249_T_G / 18_31093490_T_G / 18_31080273_C_T	0.00014328639925920681 / 0.026176748525728964 / 0.004444668756137834	0.002053875263128439 / 3.7895626071773765e-05 / 1.9855794171946574e-05
458	MBD1_4	18_50276088_C_A / 18_50276601_A_G / 18_50275492_T_G / 18_50275430_G_A	0.00014793743904567252 / 0.01877342572270696 / 0.003092273916220477 / 0.0033406482616730533	0.002775832151787685 / 0.0007205116796968372 / 0.027183042271681262 / 0.047488972926164726
459	KIAA1671_2	22_25029373_T_C / 22_25170874_A_C	0.00015698694769979702 / 0.0006020288880688977	0.04147687852552058 / 0.03878706897291035
460	MET_3	7_116740945_T_G / 7_116757685_T_G / 7_116740947_C_G	0.00016797515698396606 / 0.002832945772163542 / 0.002231117554658809	0.00017295700570667475 / 5.0554093231126755e-05 / 0.0012218666498089645
461	RCBTB1_2	13_49585356_T_A / 13_49533768_G_A	0.0001756869709333519 / 0.009455073314037034	0.02533885676009956 / 0.019692263494698818
462	PPL_4	16_4883459_A_G / 16_4894423_G_C / 16_4901058_T_G / 16_4891747_T_G	0.0001758787943382569 / 0.0007098905861696843 / 0.0005647077594982514 / 0.011689794335935037	0.009286392985327631 / 0.04550405331166151 / 0.01682150071796396 / 0.0032410422551606864
463	TMEM63A_3	1_225856800_GC_G / 1_225856891_C_T / 1_225845173_C_T	0.00017631469170194104 / 0.0005047149993335916 / 1.5371108451049484e-05	0.04262290781357216 / 0.031894233309554584 / 0.039853481810337744
464	KDM4B_5	19_5110783_A_G / 19_5047680_G_A / 19_5111856_C_T / 19_5152376_T_C / 19_5114105_T_G	0.00018149502531503815 / 0.0011449297013059851 / 3.0255655048228253e-05 / 0.0056532335440754155 / 0.005029743152006167	0.0038743952075057523 / 0.0010649511420676163 / 0.008640482718151363 / 0.012419815562589162 / 0.0315424322762135
465	TAF4B_2	18_26286027_C_A / 18_26293570_AT_A	0.0001933876544072626 / 0.0006065453361074753	0.005234163638807017 / 0.02416136973363145
466	MAP2K7_3	19_7905750_A_G / 19_7911231_T_C / 19_7910579_A_C	0.00020437876506728577 / 5.172101478935253e-05 / 6.985639899444967e-05	0.026466975715454883 / 0.014436739312155004 / 0.014559538606612087
467	EGFR_5	7_55160480_C_T / 7_55170771_T_G / 7_55205133_G_A / 7_55181370_G_A / 7_55205662_A_C	0.00020841604787297526 / 0.00045465182013688124 / 0.02209047666362801 / 0.00015707737069901731 / 0.0019734565993096485	0.042584839287283 / 0.004588325394927623 / 0.003745674667154008 / 0.030349772078527886 / 0.0007797573368817686
468	MED4_2	13_48079728_CAAA_C / 13_48077399_A_AT	0.00021592440051490123 / 0.00970359638804136	0.028274397927711425 / 0.04285821577494423
469	PSMG1_2	21_39183425_G_C / 21_39175728_T_C	0.00022608775731841645 / 0.012584465994979182	0.00513068025831651 / 0.006708397725563725
470	SYMPK_3	19_45823908_G_A / 19_45835234_G_A / 19_45842628_T_C	0.0002277738548719044 / 7.560389488032653e-05 / 0.007665716537369837	0.03948007686982654 / 0.026714512477614062 / 0.0420060391850977
471	CNKSR1_6	1_26180299_A_G / 1_26181802_G_A / 1_26181989_T_C / 1_26183270_A_C / 1_26184255_A_C / 1_26180691_T_G	0.00022855371657961118 / 0.000553633072814145 / 0.004976293349453925 / 0.0012311577321858017 / 0.00011380023959208459 / 2.366839986118124e-05	0.0031268776228605263 / 0.042309660108738684 / 0.031585176815995236 / 0.007340521806393782 / 0.03620130672603948 / 0.0014019419704167026
472	LGR4_3	11_27373900_C_T / 11_27380156_G_A / 11_27368981_G_A	0.00022889582425503487 / 0.00022889582425503487 / 7.68908468665983e-05	0.02925705779271898 / 0.02925705779271898 / 0.007261247877037425
473	VTCN1_3	1_117157003_C_T / 1_117172345_T_C / 1_117172578_ATTT_A	0.0002510217205927707 / 8.944919469827468e-06 / 0.016016251707355836	0.03055768777478911 / 0.023227355162109414 / 0.001594504991034824
474	CRBN_6	3_3151010_G_T / 3_3152273_A_C / 3_3154589_AT_A / 3_3175444_AT_A / 3_3179746_C_T / 3_3150840_A_ATAAC	0.0002626503373527541 / 0.013274951670738794 / 7.062286693324899e-05 / 0.0004048382754165016 / 0.003012811333138018 / 3.124023410218089e-05	0.0018118056645904023 / 0.00018124433406194467 / 2.1732312542326866e-07 / 7.214198132928058e-05 / 1.1224125713318842e-06 / 3.115850854605648e-06
475	SMCHD1_5	18_2707621_G_A / 18_2724932_A_T / 18_2763699_C_T / 18_2656105_T_G / 18_2795854_A_G	0.00026503656166190905 / 0.009320150621080624 / 0.0042306245640629115 / 0.025865035105419227 / 0.0001080554536414254	7.290016375189198e-05 / 0.03677531412547839 / 0.02250972081801197 / 3.289863234127764e-05 / 0.037011899642268684
476	HDAC11_2	3_13496579_C_G / 3_13496863_T_TG	0.00027757125208069643 / 0.00015267586088891374	0.0271728892750038 / 0.0149184097594151
477	PIK3CD_4	1_9720778_T_G / 1_9721354_C_G / 1_9722498_C_T / 1_9710297_C_T	0.00030314689537509136 / 7.877458405180158e-05 / 2.4181398805762395e-05 / 0.002966501395718009	0.0012148539768169404 / 0.04037203630033394 / 0.011926248274336807 / 0.011351289482054416
478	GCDH_3	19_12891586_G_C / 19_12891749_T_G / 19_12899706_A_G	0.000306793254674835 / 0.0003686903209515677 / 0.009343822168831345	0.0326186066813529 / 0.03376530749875928 / 0.00026130883839357806
479	SEC11C_2	18_59152698_T_C / 18_59158845_T_C	0.00030911539588566946 / 0.00956493460787828	0.0022574597582570113 / 0.029955010760308976
480	SAFB_2	19_5667193_AC_A / 19_5668433_GT_G	0.0003098805881779707 / 0.044739771014985504	0.002063538258127222 / 0.0026106809691974946
481	ATP6V1B2_3	8_20212278_G_C / 8_20218183_C_A / 8_20214681_A_G	0.0003172005709671975 / 1.980177091110716e-06 / 7.277973285376886e-05	0.001539493748390498 / 0.02168738622123026 / 0.025450124159694176
482	PUS3_4	11_125896149_C_A / 11_125896278_A_C / 11_125896309_G_C / 11_125896312_C_T	0.00031902172789162014 / 0.0016768215144890312 / 0.00019026344698916655 / 0.0006367828673033801	0.02249427642441209 / 0.03343255062895107 / 0.0192679955094738 / 0.02546202950317841
483	XDH_2	2_31383804_G_A / 2_31398732_T_C	0.00033628525023115955 / 0.007506095065621764	0.04221528923752448 / 0.006330815240399064
484	WDR7_4	18_56679573_T_G / 18_56781547_G_A / 18_56815915_A_G / 18_57027330_A_ACGGC	0.00034150498667130327 / 3.859660027634848e-06 / 0.002362739963128272 / 0.006245785108127786	1.7583606026050092e-08 / 0.0071713352600959014 / 0.003286339206119661 / 0.04783850584421885
485	GJB2_2	13_20189503_C_T / 13_20189241_T_C	0.00035796332888395017 / 0.008815817126700895	0.005240901157790961 / 0.03930064243744275
486	NFATC1_5	18_79486406_T_G / 18_79486978_G_A / 18_79449015_A_G / 18_79451175_T_C / 18_79467476_A_G	0.0003603073768446487 / 5.049273733042917e-05 / 0.02785434119032008 / 0.02220634088861789 / 0.0002507020345223831	0.018612271205492262 / 0.026732897678207176 / 0.0006549922975230749 / 0.0005874163668026321 / 0.003817175702412812
487	TMEM141_2	9_136791905_T_C / 9_136791680_A_G	0.0004169452454367874 / 3.984588209897019e-05	0.03333885281311693 / 0.020229651998436324
488	GON4L_3	1_155750010_A_G / 1_155813972_C_T / 1_155826993_A_G	0.0004229050700030183 / 0.009903573910672052 / 0.002653632924091959	0.014960076537640884 / 0.0034455240142541605 / 0.03840390796922083
489	THOC1_4	18_218753_C_A / 18_259800_G_GA / 18_264012_G_A / 18_260303_A_C	0.00043864187590166915 / 3.026788938964173e-05 / 6.794818264684467e-06 / 0.0036079810571773866	0.01174777561883113 / 0.04550027828580569 / 0.038030003830584136 / 0.031572528408919984
490	MOCOS_3	18_36268700_A_ATACAT / 18_36195408_G_A / 18_36195416_C_T	0.00045986586717034416 / 0.0014799368107284092 / 0.001731239408871138	3.5975000177046293e-13 / 0.007257645332317387 / 0.011340791435594116
491	TBC1D1_2	4_37920795_A_T / 4_38102880_CA_C	0.000488440493483436 / 0.0003703609091265926	0.005935046245136817 / 0.0040311926239692975
492	MYOF_6	10_93402739_A_T / 10_93335910_A_G / 10_93341723_C_T / 10_93349980_G_A / 10_93456833_C_T / 10_93379679_T_C	0.0005166123667663002 / 0.008644559399569549 / 0.030314897647199957 / 0.007378711399757192 / 0.014254715712501044 / 0.03684609798869681	0.008275987890594253 / 0.013383779511641422 / 1.0154009952651607e-05 / 0.013694532403103154 / 4.5730649026336375e-05 / 0.0006543495060757152
493	RBBP5_4	1_205096605_G_T / 1_205105296_C_T / 1_205121757_C_G / 1_205101436_A_G	0.0005227440198400762 / 0.00526416157273805 / 0.0030657012636972646 / 0.0013099169827028106	0.015139833707904771 / 0.008644227461685475 / 0.012113677398994695 / 0.04046396583686459
494	CLASP2_2	3_33577059_G_GA / 3_33684322_GA_G	0.0005299045117610777 / 0.035952102365944434	0.0005875510468728085 / 0.0001503619637647613
495	PHACTR1_2	6_13206050_C_T / 6_12749854_G_C	0.0005337924756049767 / 0.004317442990912475	0.00039532970764163586 / 0.035334891294853864
496	ANAPC4_3	4_25396670_G_C / 4_25396674_T_G / 4_25405734_A_G	0.0005663311621920986 / 0.0013075373037905336 / 0.0465779350486673	0.000361328058170187 / 0.03220079967613157 / 0.0019550422066677508
497	PSMD5_2	9_120820914_A_G / 9_120824459_T_G	0.0005809565738534683 / 0.0007453253514985393	0.02520354146772891 / 0.030923039758435706
498	ABCC3_4	17_50677651_A_G / 17_50687493_T_G / 17_50677654_A_G / 17_50661130_G_A	0.0006252991041556168 / 0.01577297864138986 / 0.003896335000953405 / 0.0010188260367160796	0.031817085633522264 / 0.0088751921752167 / 0.04421726142800319 / 0.010430910480796323
499	PDS5A_8	4_39826222_A_G / 4_39908552_GA_G / 4_39920322_A_G / 4_39928282_TCA_T / 4_39874433_GT_G / 4_39902522_ATT_A / 4_39922752_TAA_T / 4_39849438_CAA_C	0.0006804734038066716 / 0.0008478404674630213 / 0.0026866381085943365 / 0.00132808107004332 / 0.004772686052629922 / 0.0001500621143076567 / 0.007431666608049384 / 0.000683239660165417	0.013430761436295064 / 0.011566738826207195 / 0.012551712088653194 / 0.04498488242774648 / 0.0069892257136405615 / 0.002775620894064112 / 0.00845393532716467 / 0.015679705858385958
500	ARID1B_3	6_157084627_G_A / 6_157084796_G_A / 6_156779262_G_GCGC	0.0006899056725067633 / 0.00012305812201489173 / 0.003772804433314189	0.002480449952777213 / 0.003319459056638543 / 0.0297382920893214
501	ATP6V1D_2	14_67347484_T_C / 14_67347517_C_T	0.0006971003770886628 / 0.004311412775348075	0.0458931703260112 / 0.04673425843690365
502	TSPAN15_2	10_69506088_T_G / 10_69506076_T_C	0.0007322830521084773 / 0.005306461981362982	0.002401654647845401 / 0.00014212528801531312
503	MLH1_3	3_37007142_A_G / 3_37012077_A_G / 3_37042249_A_G	0.000740971042730754 / 0.00173625605182141 / 0.0001471514352872128	0.0011032555560560838 / 0.0188504234858543 / 0.00278116952700519
504	MCPH1_10	8_6563013_A_G / 8_6414878_G_T / 8_6415022_A_C / 8_6442011_A_G / 8_6444662_G_C / 8_6621439_C_G / 8_6621761_G_T / 8_6643023_C_T / 8_6643230_C_G / 8_6445504_G_	0.0007930301578494862 / 0.00783515709942311 / 0.0010653421345075958 / 0.01109994940299345 / 0.01748605668447073 / 0.014338437252537204 / 0.004071842491061435 / 0.0006919647053001271 / 0.012376440045340064 / 4.6837103256950894e-05	0.013491192511465546 / 0.00030214631498362885 / 1.4308699249286362e-06 / 0.000801511853950485 / 0.0006599247173344139 / 0.00022140087416861568 / 6.162352636469756e-05 / 4.2830362262517274e-05 / 0.0016916243554951818 / 0.00023822828634849838
505	APLP2_2	11_130110790_G_A / 11_130141602_T_C	0.0008186783504663072 / 0.005144250183511083	0.0021295365540794004 / 0.003817157441436617
506	GDF11_2	12_55743444_T_G / 12_55743453_A_G	0.0008261007388543191 / 0.03983988128537546	0.0038399667498981156 / 0.009308695658692865
507	DHRS1_2	14_24296416_G_A / 14_24296478_G_A	0.0008309168215997886 / 0.0004203355659529219	0.0011625249597744401 / 0.0009759887418146756
508	HMBOX1_2	8_29019076_C_G / 8_29049138_T_G	0.0008669919525569822 / 0.03171806222754735	0.004301459569275475 / 0.002544858829830765
509	FAM129B_3	9_127525147_A_C / 9_127531490_GA_G / 9_127578821_C_G	0.0008771327036108232 / 0.0021288478614580747 / 0.0022519852618096852	0.020053464930431048 / 0.031013612085774283 / 0.0009666899162254512
510	SQRDL_3	15_45676245_C_G / 15_45659211_A_T / 15_45659215_T_A	0.0008907771597097484 / 0.0020094614120517293 / 0.009204846533756823	0.014234174047984662 / 0.023564046281648054 / 0.01334902621156353
511	PAWR_3	12_79621127_A_T / 12_79621127_A_C / 12_79690012_G_C	0.0008953392161992621 / 4.018282599405261e-05 / 0.00946824676498348	0.00916697548400727 / 0.004195646894367022 / 0.04023621560178265
512	ZMYM4_2	1_35386039_A_G / 1_35398970_A_G	0.0009255268514009688 / 0.0010268025209398274	0.047414902378186935 / 0.03220211892803819
513	PNISR_3	6_99400577_G_T / 6_99400380_A_T / 6_99400680_T_C	0.0009649647745143484 / 0.0007159697124499053 / 0.04773876660712681	0.00024058514444646938 / 0.04850971607266792 / 4.045878429706501e-05
514	KCTD1_2	18_26455686_TTTTG_T / 18_26455824_G_A	0.0009651254517760071 / 0.00044897282981570764	0.011878660133524677 / 0.022677959399150814
515	YEATS4_4	12_69360050_G_A / 12_69360067_T_C / 12_69365771_AT_A / 12_69359732_G_C	0.0009657838134951767 / 0.010865427433622845 / 0.00010196861904854136 / 0.004781622790417561	0.00020734016607029562 / 9.576513142549652e-05 / 0.005769237544482665 / 0.00015854860163792644
516	MYH14_4	19_50257459_C_G / 19_50268152_A_C / 19_50223372_A_C / 19_50210705_A_C	0.0009907478792200786 / 0.00031027234534027856 / 0.009603188672713292 / 8.610623849100771e-05	0.003155642857162157 / 0.02679430539669753 / 0.04503905394492344 / 0.01011266806040028
517	TNRC6B_3	22_40246081_G_A / 22_40322746_C_G / 22_40270313_CTT_C	0.0010055560691593062 / 0.007906209412661305 / 0.009164202590452458	0.0005779404176446281 / 0.0047436478866502065 / 0.0364705418337816
518	INTS9_7	8_28780706_C_T / 8_28787754_C_T / 8_28793781_A_C / 8_28793783_A_C / 8_28835266_C_T / 8_28775581_A_C / 8_28775811_A_C	0.0010081741289715016 / 0.004592362992120706 / 0.0005120698884621372 / 0.0002773767656391789 / 0.02714848429874154 / 0.00020236348372473448 / 2.4854306942254155e-05	3.2138156864211546e-07 / 5.188443093736729e-09 / 4.024976616918393e-06 / 2.0930318384840388e-05 / 1.818850464108077e-06 / 3.257318543578891e-07 / 0.018623738854211223
519	SLC9A2_2	2_102708404_T_C / 2_102683152_T_C	0.0010228970665369316 / 0.0005020081620733607	0.009615984790689362 / 0.009480536166577638
520	CABYR_2	18_24159761_T_C / 18_24143046_A_T	0.0010567833091170056 / 0.0014968601112293539	0.005047158957377522 / 0.04396847891686953
521	GTF3A_3	13_27435783_G_C / 13_27434894_G_C / 13_27424632_T_C	0.0011190222584791265 / 0.004681955550098893 / 0.007918207229892667	6.8305505569380366e-06 / 4.651074413645253e-05 / 0.009084963551764854
522	C17orf80_2	17_73243051_A_T / 17_73243095_T_G	0.0011654886198261731 / 0.004494422448579687	0.010085515976883222 / 0.004743723689710052
523	SMU1_3	9_33042147_G_GC / 9_33048282_A_C / 9_33062151_T_C	0.0011669696398791268 / 7.696816352170192e-06 / 0.01499894245869885	0.04706645923394905 / 0.031220105263435657 / 0.0036210535474734524
524	APP_3	21_25881669_T_G / 21_25982373_C_A / 21_26053118_T_G	0.0011674640267523098 / 9.245713138747127e-05 / 0.004308340981093568	0.0009005203285702301 / 0.013334900192842466 / 0.04036723851049838
525	SF3A2_2	19_2247907_A_C / 19_2248684_C_T	0.0012266864812599976 / 0.002990131415570729	0.0030981828107111728 / 0.0468855780292127
526	MCM3AP_14	21_46242985_CA_C / 21_46245202_GAAGA_G / 21_46254361_G_A / 21_46256797_G_A / 21_46257020_T_C / 21_46258860_A_G / 21_46261213_T_C / 21_46265873_T_C / 21_462660 25_A_G / 21_462_	0.0012527393891514607 / 0.00036535930217642055 / 0.0024609384326425487 / 0.04643229751040803 / 2.118510728826028e-05 / 2.887414182548247e-06 / 1.05276826358399e-07 / 0.00025970635193207507 / 0.0005620952054741439 / 5.716570824504117e-0726	0.0002736694696369044 / 1.7616074069549246e-05 / 1.3003369428929314e-06 / 2.3123117180340123e-05 / 2.0562643179742515e-06 / 8.354163607590267e-05 / 0.00029806921327546384 / 5.3648509797744586e-06 / 1.5227506753175702e-05 / 7.2 511 625 / 1.858126949270524e-05 / 3.8129306546053804e-06
527	CLIP4_2	2_29160508_G_A / 2_29167435_A_G	0.001256177781998004 / 0.0032393618837062445	0.004054702946614456 / 0.02363327883448803
528	TSC22D1_3	13_44574373_G_T / 13_44574380_T_G / 13_44573675_A_G	0.001377124084836583 / 0.015722049040498624 / 0.02470162730235456	0.0064804726533923464 / 0.0020304861527569297 / 5.907708401459935e-06
529	PKP3_3	11_403980_G_A / 11_404317_C_T / 11_397331_G_C	0.0013876622699982295 / 0.016481995505848203 / 3.1228708373215485e-07	0.018674886861837936 / 0.009799627021991927 / 0.04880244320980319
530	CASP8AP2_4	6_89867828_C_A / 6_89846678_CT_C / 6_89854793_T_G / 6_89867387_T_G	0.0013957399418989352 / 0.0012351347166879073 / 0.01485793169450881 / 0.029929799896047743	0.004638447540709211 / 0.00012650141154496166 / 0.0049509957510286366 / 0.007919221858804896
531	SUGP1_3	19_19297181_T_G / 19_19320614_T_G / 19_19321154_G_T	0.001497727430536191 / 0.0019392453885837852 / 1.1604792778575085e-06	0.004713359874536658 / 0.0005015062282813169 / 2.8690586178505662e-05
532	MTMR14_2	3_9701714_TGGAG_T / 3_9688859_C_T	0.0015228522402605245 / 0.0034777774244127892	0.0064175485415249155 / 0.007328897092709648
533	RIOK2_2	5_97167674_T_C / 5_97179013_C_G	0.0015264299232640686 / 0.0009434563320843556	0.018107759921786072 / 0.01839083931192911
534	HCLS1_5	3_121631746_C_A / 3_121642799_G_A / 3_121642940_G_A / 3_121647276_C_T / 3_121647530_A_G	0.001531370286315401 / 0.007140010061027548 / 0.0056491920403494 / 0.0056491920403494 / 0.0033035345652737084	0.008666157872154578 / 0.028236059065420614 / 0.02925717871219745 / 0.02925717871219745 / 0.035251625940568736
535	USP20_2	9_129868385_TGAC_T / 9_129868775_T_C	0.001542609843192008 / 0.006644626432996628	0.028200134219961023 / 0.0362382211673806
536	OGT_3	X_71555839_AT_A / X_71555852_A_G / X_71556880_G_A	0.0015512975406232336 / 0.0006090442157279421 / 3.794330620993244e-05	0.03251106613283236 / 0.03051485289420325 / 0.02757062507023744
537	ILF3_4	19_10677068_C_G / 19_10683073_A_G / 19_10683954_G_T / 19_10689074_T_C	0.0015595887966999382 / 0.0008443307208163777 / 0.0014177004651836508 / 0.006992884477782401	0.02905299869911714 / 0.023662506952371584 / 0.024462171404793464 / 0.04401306590016355
538	AKAP17A_6	X_1593528_G_T / X_1593824_T_C / X_1593829_A_C / X_1593416_T_G / X_1599467_G_A / X_1601004_C_G	0.0016145426205006856 / 0.006626142886833432 / 0.0006549722036186197 / 1.3622821646377586e-09 / 1.4367220837077828e-05 / 0.0013113963664485734	1.7500984806304813e-06 / 0.004424305821371996 / 0.031339887946813465 / 0.0002164120997390045 / 0.0019808227552202268 / 0.022975239267281157
539	HLA-DPB1_25	6_33084838_T_C / 6_33086094_A_G / 6_33086100_G_A / 6_33086430_A_G / 6_33086431_C_T / 6_33086458_T_G / 6_33086503_T_C / 6_33086504_G_A / 6_33086525_T_C / 6_33084940_A_C / 6_33084942_G_A / 6_33084946_C_G / 6_33084959_G_A / 6_33086548_G_C / 6_33086623_T_C / 6_33086627_A_G / 6_33086636_T_G / 6_33086637_T_A / 6_33084934_T_C / 6_33086390_G_A / 6_33086399_T_A / 6_33086400_T_C / 6_33086554_T_C / 6_33086565_T_A / 6_33084918_T_G	0.0016170360777901915 / 0.035517335536449965 / 0.03859616732889496 / 0.0050484605719981115 / 0.006920322099559346 / 0.04723136941351201 / 0.01042058063158112 / 0.01982161136592692 / 0.004676661817713314 / 9.909297446240884e-05 / 0.00013864663028350917 / 0.0002553757712440544 / 0.00010148054048444211 / 0.0005733999890735651 / 0.001447191231242919 / 0.0006504207970493822 / 0.0014159972834331574 / 0.0011151099996242373 / 1.670066308093462e-07 / 0.002181120675090949 / 0.001551134422399547 / 0.001551134422399547 / 0.00018558558739674276 / 0.00027961484945332547 / 0.04098305035004495	.01738899621763897 / .0071970972262367875 / .0015085198751619124 / .009855204235078744 / .009159540445250336 / .0034148006003537623 / .0007725393378843376 / 0.00046914802311591013 / .0002211234236168895 / .01812705600921171 / .02551712776803155 / .02768815887474311 / .01961732896362046 / .00424548612011435 / .03272474670019398 / .034386513937956574 / .03829938821939845 / .02718298788851184 / .0008766728067700178 / .0010412174325617669 / 0.00027430911944352433 / 0.00027430911944352433 / .007068880728833383 / .0015589855961860727 / .0023729962607638784
540	ERBB2_7	17_39723335_A_G / 17_39725167_A_G / 17_39727303_T_G / 17_39723531_A_C / 17_39728154_A_C / 17_39709434_A_C / 17_39728753_A_G	0.0016350878443782172 / 4.136237081824547e-05 / 0.046602377151608726 / 0.0033861558195955052 / 0.0037588249676302338 / 0.03412502593916668 / 0.0037443415073794024	0.030443197190865717 / 0.016249088634527818 / 0.0009745478853255011 / 0.014043142620610086 / 0.002489169967351341 / 0.005151661954164628 / 0.0238332618696792
541	CNOT10_5	3_32773739_A_T / 3_32705030_A_G / 3_32717271_G_A / 3_32727933_TAA_T / 3_32704796_GT_G	0.0016526003311275095 / 0.0001231320148601887 / 0.00017728596732259782 / 0.009536795008099045 / 0.003991838672618705	0.0019461949221222566 / 0.0007110070373588129 / 0.0032142136890770555 / 0.009535253937430231 / 0.00725632017358903
542	BTAF1_3	10_91959744_A_G / 10_91959746_A_G / 10_92024732_G_GTTTTTTTGTT	0.0016639394777511788 / 0.017417232932444852 / 0.002725136934144748	0.0011854132574195902 / 0.002486161819230707 / 0.02294891315626264
543	KDM2B_2	12_121579961_G_A / 12_121444386_T_G	0.0016808767205032673 / 0.0018129427277068664	0.04715734536774355 / 0.019501973878425127
544	OSBPL8_3	12_76371622_A_G / 12_76459031_C_T / 12_76389816_G_A	0.001685976661542144 / 0.0019376612844524102 / 0.00034069060776455845	0.010145024239484482 / 0.023570151478943115 / 0.01081801975958232
545	SPATS2L_4	2_200477598_G_T / 2_200412421_T_G / 2_200477943_T_G / 2_200473083_GAA_G	0.0017077762924250339 / 0.005542406637614594 / 0.008957206491580714 / 0.02371288438579117	0.021972245787165747 / 0.03547678698863923 / 0.016080388811817628 / 0.0009052273948575811
546	KMT2C_2	7_152273692_G_A / 7_152177504_T_G	0.0017215770748878 / 0.0257040166730586	0.02044755694417402 / 0.0007976241891358237
547	C3_8	19_6679370_G_T / 19_6679500_C_T / 19_6679552_T_C / 19_6693625_A_G / 19_6710771_G_T / 19_6713164_G_C / 19_6713251_G_A / 19_6718376_G_C	0.0017242987096359706 / 0.011130009901872313 / 0.01112305118572054 / 0.03308700773309592 / 0.0007547726119911367 / 2.8401856724118085e-05 / 9.337374703033051e-05 / 0.00015757450123976866	0.021139612203482698 / 0.001328408206242609 / 0.0024788445051524576 / 0.009567716450671235 / 0.00949274728217466 / 0.015144191214707904 / 0.01135067374028043 / 0.013151961372936128
548	NFX1_3	9_33290534_A_G / 9_33290690_G_C / 9_33344254_T_A	0.0017340354418381332 / 0.00213071003554307 / 0.0008944872419168263	0.004533123491706767 / 0.03459515757598255 / 0.005356381351212509
549	KATNAL2_4	18_46963135_T_TGC / 18_46969062_T_TGC / 18_47028569_T_TGC / 18_47069438_A_T	0.0017826363249020844 / 0.0002158210829164119 / 0.002959998960433205 / 1.0166082620431142e-06	0.023566439092900897 / 0.042581318341999685 / 0.01792891562738572 / 0.04594422713064072
550	PLRG1_8	4_154538042_A_T / 4_154539961_T_C / 4_154540535_A_C / 4_154540996_A_T / 4_154544383_A_G / 4_154545783_T_C / 4_154546035_A_G / 4_154548807_G_GA	0.0017837327552204187 / 0.0022747756662197635 / 0.013232282684609756 / 0.006089524083842604 / 0.023466965037692716 / 0.011286717487280188 / 0.015766497021373137 / 0.001132424851953552	0.0025156591482322463 / 0.003876861205834139 / 0.008064183834782563 / 0.004736898325652559 / 0.004629934695328492 / 0.00625636632504058 / 0.006403275082048386 / 0.0051675452547446255
551	EDN1_2	6_12295840_T_G / 6_12295843_T_G	0.00181409210724337 / 0.0002763328454078789	0.024241257142762068 / 0.012273310260196891
552	RABEP1_2	17_5381248_TAA_T / 17_5361621_C_T	0.0018150712755665734 / 0.004152920156402154	0.007056745600928623 / 0.01880219353285387
553	RUNX3_2	1_24907301_T_G / 1_24907326_T_G	0.001835528705698884 / 0.0008816631461578386	0.0479402881785652 / 0.03367486268556343
554	ARID3A_2	19_929678_G_A / 19_965056_A_C	0.001844502898018781 / 0.0038221459346221604	0.0024448512910076343 / 0.038475803182823655
555	SETD2_6	3_47037622_G_A / 3_47083895_G_A / 3_47084411_A_C / 3_47084426_CT_C / 3_47101417_TCC_T / 3_47121171_A_G	0.0018886443163515503 / 0.0005724676673950148 / 0.0018507014329319895 / 0.002298087295161151 / 0.0018577181187481573 / 0.000573845912909288	0.000977617083994294 / 0.008205866594339892 / 0.008011204119723829 / 0.009083566444260623 / 0.0015764712914139378 / 0.0002475067417184235
556	MYO1E_4	15_59272288_G_C / 15_59223315_G_A / 15_59178167_C_T / 15_59138181_A_C	0.0019255092745879315 / 0.027929898310990055 / 0.00031389151980896725 / 0.04411515555617615	0.006181875879725325 / 0.0073567891788311425 / 0.014590984354000915 / 0.000506485287819266
557	SUGP2_5	19_19024510_A_G / 19_19025732_C_T / 19_18994964_G_A / 19_19026233_T_A / 19_19010089_T_G	0.001983285518752092 / 0.002941993796204625 / 0.01284029709782453 / 0.0020741831309949127 / 0.0008037924072482433	0.040831519054544435 / 0.008182273259557721 / 0.005749298256034085 / 0.007605074821863024 / 0.027745888328438603
558	KLHL18_3	3_47319581_T_G / 3_47344095_C_A / 3_47322481_G_T	0.0021891626387678365 / 0.0006911454072889093 / 0.0001458644297550943	0.013218876001835087 / 0.0063137500959640856 / 0.018113274866617776
559	TYSND1_2	10_70138599_C_T / 10_70140172_G_A	0.002210990629147794 / 0.0039640911222843436	0.009659099597965872 / 0.027700702531791875
560	EIF1B_5	3_40309993_C_T / 3_40311393_C_T / 3_40311934_CAG_C / 3_40311768_T_G / 3_40309649_C_G	0.0022271726409335488 / 7.503385234156634e-05 / 3.177548305907501e-05 / 2.1365604310883664e-06 / 0.006831469965345718	0.005496962588873379 / 0.0028348307389023737 / 0.0036905138907599726 / 3.949648255514959e-06 / 0.04857611284248277
561	C14orf79_2	14_104991443_T_G / 14_104992803_A_C	0.0022393155386724074 / 0.009479451263550959	1.7720854995940125e-07 / 7.586102006604381e-07
562	SLC52A3_2	20_761203_A_G / 20_763790_T_G	0.002271842149158581 / 0.0019785326127115858	0.0003747217630289052 / 0.003089764091274667
563	HDAC5_2	17_44087216_A_G / 17_44077102_A_G	0.0022775299741103626 / 0.009100177186215046	0.03161998848113075 / 0.021561030479614426
564	TCF7L2_4	10_112951117_C_T / 10_113165703_A_C / 10_113165557_GA_G / 10_113141157_T_G	0.0023062734857754803 / 0.006196689121801137 / 0.00015949311848004983 / 0.01042058063158112	0.01060529288873283 / 0.008309178089758909 / 0.04233413143117931 / 0.004504822920252362
565	DSP_2	6_7577915_A_C / 6_7581379_A_G	0.002345981327408041 / 0.02625851263459552	0.0018316675069518392 / 0.005935959963292785
566	GAS7_3	17_9943314_G_A / 17_9943407_C_A / 17_9940079_A_C	0.0024862474118096554 / 0.02161659825841676 / 0.01209844734945125	0.014304203615809547 / 0.007643530014898026 / 0.02182596122662912
567	ARHGEF5_5	7_144365079_A_C / 7_144371121_T_C / 7_144371117_T_G / 7_144364997_T_C / 7_144365475_T_C	0.0024945926126355923 / 0.02354548207827752 / 0.006211748094610735 / 0.002934715516170928 / 1.727507617843059e-06	0.02343547139067424 / 0.007520412833757487 / 3.130275501973943e-06 / 0.02778730920062768 / 0.003065464879158348
568	PTPRU_3	1_29275579_A_C / 1_29310715_T_G / 1_29255395_A_C	0.002539773248455689 / 0.0077226993558171956 / 0.0009778041944005973	0.007805553893565897 / 0.021084479691732515 / 0.046498222792818684
569	TTC39A_2	1_51288088_T_G / 1_51295930_G_T	0.002570863553329518 / 3.4909921895622464e-05	0.0009000808652072745 / 0.009859747746545187
570	KRT15_3	17_41516910_C_A / 17_41518370_T_G / 17_41518744_A_C	0.002573274763251264 / 0.011567941016623695 / 0.003420135618507444	0.005435309336568784 / 0.004600527769071169 / 0.020891294013713143
571	UBXN8_5	8_30744093_TC_T / 8_30744288_C_T / 8_30751256_A_G / 8_30751544_T_G / 8_30751561_A_T	0.002591192476579632 / 0.0006909486125387932 / 0.02443874890142141 / 0.03582659928743899 / 0.03582659928743899	1.0603773748192244e-05 / 4.865545060608271e-05 / 6.152112049146202e-05 / 3.811929186552625e-05 / 3.811929186552625e-05
572	SMARCA4_3	19_11003321_G_T / 19_11010261_C_T / 19_11026459_T_C	0.002630441388397466 / 0.010463060303081006 / 0.010088756192701873	0.010970724428159849 / 0.007818649393052565 / 0.008366105586796981
573	PSMD6_2	3_64018733_C_CA / 3_64023832_T_C	0.0026976125076584256 / 0.009878175034845338	0.010870617478385693 / 0.0044822108745555264
574	CCDC18_7	1_93226524_AAT_A / 1_93232665_C_G / 1_93180876_T_C / 1_93221838_T_C / 1_93239253_G_A / 1_93226314_TG_T / 1_93180563_T_G	0.0027123682464393244 / 0.0016657739488188466 / 0.0033797977817805816 / 0.0015978624867728733 / 0.002134999320804664 / 0.013590020119742256 / 0.003793743444563949	0.04835531632243841 / 0.0045740699346053185 / 0.00032147121850177287 / 0.0017542576026547778 / 0.0017542576026547778 / 0.003812032810040999 / 0.0440564257256616
575	MKRN2_2	3_12572367_T_C / 3_12576770_C_T	0.0027864675750747985 / 7.698740851570175e-06	0.0004133954800997532 / 0.00023875055451781275
576	POU2F2_2	19_42122415_A_C / 19_42116791_T_G	0.002831354927429977 / 0.00132487414614545	0.0009318465407261826 / 0.03195305321524156
577	CSNK1G2_2	19_1941300_C_CG / 19_1978367_A_C	0.002838297409364801 / 0.002057750736247525	0.0019266812436141687 / 0.04165592627236607
578	NADK_4	1_1754601_G_T / 1_1755504_T_C / 1_1755523_C_T / 1_1757030_C_G	0.0029196774804306136 / 0.0022487075080235863 / 0.0010425578675322944 / 0.004582127513664698	0.031872533533518106 / 0.005752610352558396 / 0.0031781335571060463 / 0.03556781287056178
579	CD151_2	11_837662_TG_T / 11_835877_C_T	0.003028852216804449 / 0.04104019245722205	3.3851264417503082e-06 / 0.005759250847020773
580	ATP5A1_9	18_46098069_T_C / 18_46086016_C_T / 18_46086895_T_C / 18_46086986_C_A / 18_46087562_T_C / 18_46088355_G_T / 18_46090014_T_C / 18_46098295_T_G / 18_46090084_G_T	0.0030434677700528394 / 0.0004952827031339936 / 0.007810554102540824 / 0.000648733348082285 / 0.013897849420604671 / 0.002385765549363269 / 0.0010062790676919331 / 0.005315177457540565 / 0.01959258956571804	0.0003047097440701736 / 0.0142075393191002 / 0.036323160579493724 / 0.013872652612254888 / 0.0036567482317310593 / 0.02085147005163321 / 0.01507674177782532 / 0.03454712220311499 / 0.007087269321528623
581	ACTR8_2	3_53876892_G_GT / 3_53876872_GA_G	0.003050264516832101 / 0.008934315374097621	5.979539416096826e-07 / 0.005988354207232076
582	KDM4C_3	9_7105548_G_C / 9_7170165_G_A / 9_7174813_T_A	0.003056285777006115 / 3.848309807154845e-06 / 0.028252899669062883	0.04853749604959928 / 0.04549941716484139 / 0.006907446061910031
583	AZI2_2	3_28331971_C_CA / 3_28340396_A_T	0.0031048857689516462 / 0.003592307504254993	0.014552320913166257 / 0.004305743220750069
584	SERTAD4_2	1_210241533_TC_T / 1_210241536_T_C	0.003132119859215549 / 0.009639231593611885	0.019963608830813308 / 0.006491338228956634
585	USP15_4	12_62302696_T_G / 12_62383784_G_T / 12_62404146_G_T / 12_62335441_G_C	0.0031338510061822643 / 0.014094139089898441 / 0.0031672583932668176 / 0.002293994252085232	0.00033081922207003954 / 0.0033557619531166464 / 0.00033479875073063453 / 0.039619833047337696
586	DOCK1_3	10_127012556_G_A / 10_127444251_G_A / 10_127248024_G_T	0.0031585127425178675 / 0.027688640963832358 / 0.0004879172723173928	0.004938898221400919 / 0.007801850145866487 / 0.020184142497530616
587	ITGB4_4	17_75736347_G_A / 17_75739839_G_A / 17_75742534_T_C / 17_75754823_A_C	0.003162157220078509 / 0.008328692436238487 / 0.007894779942929558 / 0.009860822677928005	0.01217344559335353 / 0.002457354260511787 / 0.01159864028497844 / 0.005496381411893582
588	ZDHHC17_2	12_76843188_G_A / 12_76815330_A_G	0.0032793703796479517 / 0.0004434027342669209	0.011228793208829205 / 0.0047926477879100746
589	STEAP4_2	7_88282586_G_A / 7_88283906_C_T	0.003287923696320924 / 0.0091566014690908	0.020956268813510096 / 0.020511289316670928
590	SON_2	21_33553093_A_C / 21_33553095_T_C	0.003287986051022628 / 0.0002182856164179604	0.023262781799198717 / 0.04085529307129965
591	SUZ12_2	17_31937449_T_G / 17_31937443_C_G	0.0032919118028606463 / 5.6901277653871055e-05	0.001414433092115542 / 0.02301260051890533
592	ZNF708_5	19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A / 19_21294601_T_G / 19_21310453_A_T	0.003305225750188495 / 0.0035049021956979373 / 0.004520698246333428 / 0.0002495831365867789 / 0.0067675270617948155	0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05 / 0.0371668734968966 / 0.010566885319869566
593	NPAT_3	11_108173261_C_T / 11_108188273_T_C / 11_108222481_A_T	0.003344965508099712 / 0.00917775939993597 / 0.039703241026176714	0.002496786878352684 / 0.04574657942913745 / 0.0037813176541691743
594	HSPG2_4	1_21848107_A_G / 1_21857246_A_G / 1_21854055_T_C / 1_21885485_A_C	0.003347609104205378 / 0.0006068526113653472 / 0.003704007084337551 / 0.00357256954025205	0.02697977272492986 / 0.03734459078034153 / 0.0018455746031783011 / 0.028105372966297285
595	TOP2B_6	3_25618603_G_GT / 3_25620066_T_TA / 3_25630287_C_T / 3_25632344_A_C / 3_25632600_C_A / 3_25638247_T_C	0.0033763968792717173 / 0.008450908635462133 / 0.0012336549489001688 / 0.00024044846753362568 / 0.0010363758807633305 / 0.0007533307901546944	0.009406841430847504 / 0.006029442482514222 / 0.011303133266640238 / 0.01883862996744124 / 0.018119501937010576 / 0.00877690000990295
596	MUC16_3	19_8894929_A_T / 19_8979498_T_G / 19_8957088_C_T	0.0034029575974152395 / 0.00041258558252529193 / 0.001514661605616884	0.03041637790901308 / 0.002432253712629655 / 0.03213344574711092
597	TMEM144_3	4_158244471_A_C / 4_158253356_T_G / 4_158253361_T_G	0.0034876691228988683 / 0.0005647077594982514 / 0.0008326481477321537	8.607739077270522e-05 / 6.799118981257274e-05 / 0.0018072956471693355
598	SDC1_2	2_20204203_T_G / 2_20202279_A_C	0.003538404752618725 / 0.0156379764488537	0.012274967718012342 / 0.005607450656810002
599	RBM6_7	3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50075177_T_G / 3_50066484_G_A	0.0035570559373772188 / 0.00580221866025999 / 6.528791603289091e-07 / 0.001554315699435568 / 0.0007276852324929738 / 0.008508212434548797 / 0.002518709860742996	0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.000930075295183941 / 0.014325869585835831
600	FIP1L1_2	4_53377738_T_C / 4_53414538_G_GA	0.003618394551763958 / 0.000808630514933739	0.020612870650917825 / 0.014620279830838013
601	BAZ1A_6	14_34773800_G_A / 14_34761774_C_T / 14_34761902_A_T / 14_34771458_C_G / 14_34780118_A_G / 14_34862082_G_A	0.003674207621815091 / 0.00048794862757524084 / 0.0004529362621637724 / 0.00048794862757524084 / 0.0004529362621637724 / 0.0008633899521319537	0.020819109086183382 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995
602	ABLIM1_2	10_114468289_G_T / 10_114613516_C_T	0.003679575880821695 / 2.068694569003633e-05	0.013324532381057309 / 0.007365229118612223
603	KCTD11_3	17_7356629_G_T / 17_7356036_T_C / 17_7353417_T_G	0.003754571069046404 / 0.00017366868689943718 / 0.0012390848435611386	0.04600482755406116 / 0.034157938547959045 / 0.0012683162409826913
604	MICALL2_5	7_1442358_T_G / 7_1448634_T_G / 7_1438692_G_A / 7_1438940_G_A / 7_1434765_T_C	0.0037969325863282813 / 0.03384278289950645 / 0.029060946696468106 / 0.029060946696468106 / 0.0032003913710269877	0.003849439864891702 / 0.00957207447144348 / 0.001706040259270731 / 0.001706040259270731 / 0.009156797658911076
605	RFC1_4	4_39304977_A_C / 4_39317086_A_G / 4_39327482_G_A / 4_39366034_T_C	0.003804607068014229 / 0.002653298567768597 / 3.2670263647126826e-05 / 0.042208647376131	0.0020300192179148733 / 0.00027426635734190813 / 0.008638827908989666 / 0.0022061266378501725
606	AP1M2_5	19_10572926_C_T / 19_10579645_C_T / 19_10587097_A_G / 19_10587125_G_T / 19_10579014_TC_T	0.0038087692058226532 / 8.991675208563765e-05 / 1.1792724900645332e-05 / 5.261102684897293e-05 / 0.001877531631940374	0.02140839327697613 / 0.010527568877864577 / 0.0015316982164778213 / 0.023908631854345174 / 0.00821632833656041
607	RPS23_2	5_82278173_C_T / 5_82278363_C_T	0.003957786808705407 / 0.0008315075457503006	7.911328672036997e-05 / 2.402875788954321e-05
608	BARX2_2	11_129436792_A_C / 11_129436677_C_T	0.004015743982394933 / 3.8908364285059496e-05	0.0011297752143511178 / 0.006988734279853065
609	LRRC1_3	6_53913863_T_G / 6_53920478_C_A / 6_53899709_T_G	0.004131339558552957 / 0.0030469251357492584 / 1.3663885062737747e-07	0.02863343366704425 / 0.016849492489466617 / 0.0009777953947081833
610	POGZ_3	1_151423306_T_C / 1_151407350_A_C / 1_151459156_T_C	0.0041738932600083895 / 8.993795886819927e-07 / 0.008612349643764727	0.020015181832936737 / 0.02909488569964382 / 0.009809035888391762
611	PRKCI_2	3_170275187_CTTT_C / 3_170263168_CAAAAA_C	0.00425052374891476 / 0.002760121279997125	0.00012798467543814748 / 0.021989752739530143
612	PGBD1_2	6_28296652_T_G / 6_28298177_A_T	0.004288328285551539 / 0.00932669296817631	0.005702673764439882 / 0.020264770709017343
613	LGALS8_3	1_236537373_GAGC_G / 1_236539197_AGTTT_A / 1_236551447_T_C	0.00435552243438307 / 0.02490692830672263 / 0.005408439057885871	0.0007287918934518675 / 0.002689054589007359 / 0.013132223069499007
614	CYP4F11_7	19_15913852_G_C / 19_15914366_C_T / 19_15924707_G_A / 19_15927524_G_A / 19_15927580_G_T / 19_15929482_A_G / 19_15929663_T_C	0.004494422448579687 / 0.004118655653677505 / 0.009014030424870815 / 0.007737694175519336 / 0.005296914283554929 / 0.006573618747648885 / 0.0045029584577228	0.01037304937937457 / 0.022954596803030098 / 0.0124267741256932 / 0.011141708950444295 / 0.011312909542474079 / 0.016341169913201302 / 0.013422572430360932
615	ZNF24_3	18_35337816_G_GA / 18_35337680_T_C / 18_35344446_G_A	0.004517003572403403 / 0.00020451573869716152 / 0.02552298264953765	0.012709161524744772 / 0.04404021168973007 / 0.008269738810110396
616	ANKS6_2	9_98796162_G_A / 9_98778486_A_C	0.0045700537784898465 / 0.009257993261520582	0.047044500480316616 / 0.03370066145919663
617	POLR2B_6	4_56995192_C_T / 4_57010789_G_A / 4_57015549_G_A / 4_57025073_G_A / 4_57005234_AT_A / 4_57023798_AT_A	0.004738473697291275 / 0.00020500907676743697 / 0.0003428363180097953 / 0.00033030198738810576 / 0.000896266309671023 / 0.010078450270635015	0.00041802227600176717 / 0.03709404459710368 / 0.03851787302536296 / 0.03254648423802934 / 0.03704331970217288 / 0.007472844031288456
618	CDC42BPB_3	14_102939620_T_G / 14_102952453_T_G / 14_102945931_T_C	0.0049774861882444345 / 0.0002680622756333545 / 0.004938189506165365	4.775637628078603e-05 / 0.003315245095495249 / 0.001918499391114136
619	WDR62_3	19_36058788_C_T / 19_36084743_G_A / 19_36094002_C_T	0.005088637492213912 / 0.016915078735087723 / 0.007443859285838674	0.0005331846126391098 / 0.000415677937125236 / 0.0005211199976091131
620	PLCB2_2	15_40298884_T_G / 15_40297623_G_A	0.005308041472208479 / 0.0013941969299030182	0.025458039339188058 / 0.04960868971387879
621	ZEB1_4	10_31461157_A_C / 10_31521191_A_C / 10_31521414_A_T / 10_31461247_AT_A	0.005342806393282525 / 0.01137703502325166 / 0.0014780611664163069 / 5.800757504246017e-05	0.013618649263675358 / 0.006377825075174489 / 0.011119739548999731 / 0.0019400920584000448
622	NDUFAF4_2	6_96891399_CA_C / 6_96896910_G_A	0.005489763925784804 / 0.0005269475943804068	0.01909002509011261 / 0.009369364198285348
623	PHIP_9	6_78947674_G_A / 6_78954723_T_C / 6_78955031_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C / 6_78947709_T_C	0.005530164992886238 / 0.00548954353554207 / 0.01455660590235654 / 1.6913729880297845e-05 / 0.0035647193470514853 / 0.005289398736036421 / 0.001837097400913216 / 0.004209432623363282 / 0.02442132743404569	0.0010048550446085317 / 0.00648756713202656 / 0.0009432749408838033 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912 / 0.0006553233953188175
624	C6orf203_2	6_107044172_C_T / 6_107051038_GTTTTC_G	0.005594780806642859 / 0.010350958813062314	1.8543097341742985e-05 / 4.7416804336943046e-05
625	RIOK1_2	6_7390137_G_T / 6_7410502_GT_G	0.0056620989198510035 / 0.009940460227242327	0.004558417307934729 / 0.0007644747214841657
626	STX2_3	12_130796169_T_C / 12_130821769_C_G / 12_130827084_G_A	0.0057763908603848755 / 0.0026232291323331123 / 0.0017127068028307182	0.03019238327054641 / 0.01065610617547119 / 0.004236660791662807
627	DOCK9_6	13_98797273_A_G / 13_98888796_T_A / 13_98848509_C_T / 13_98902701_G_A / 13_98883901_TA_T / 13_98977850_C_T	0.005927598026328671 / 1.199291147137571e-06 / 0.00025790841294325934 / 0.0030628908663900517 / 0.003688722979152048 / 1.1373148571396284e-05	0.006004783016582045 / 0.01781055671478815 / 0.005840989451706359 / 0.025244747630348088 / 0.020609371467392473 / 0.01526774575825921
628	ADAM15_4	1_155056046_G_A / 1_155058081_A_C / 1_155058900_C_T / 1_155053372_T_G	0.005983172351155387 / 0.003608774130493322 / 0.02011005006826893 / 0.013070176515727179	0.02587883400458268 / 0.038829781369162535 / 0.006114928575864872 / 0.005438593481843924
629	ZNF430_3	19_21020746_C_T / 19_21033730_G_A / 19_21022725_C_T	0.006039060973644978 / 0.0017404412233575466 / 0.0032443389741318627	0.0014493947676260713 / 3.875366882434858e-05 / 7.931044376997757e-06
630	SLC41A2_2	12_104866497_A_G / 12_104805360_A_C	0.006042414055759166 / 0.003878181222682689	0.04584324420776458 / 0.01814258498012539
631	ARHGAP5_2	14_32092970_T_C / 14_32154828_T_C	0.006122997092230283 / 0.00899034241039037	0.000109609141495362 / 0.0028505632724505807
632	CTSB_5	8_11848168_C_G / 8_11853379_G_C / 8_11847933_G_T / 8_11852665_T_C / 8_11848361_G_A	0.006170091093918575 / 0.013883502523880249 / 0.013105854756963943 / 9.23481096080534e-05 / 0.0030280965583678638	0.010885538500044391 / 0.006363373856765906 / 0.00949712914495799 / 0.00465817682934427 / 0.02101769256107376
633	INTS10_7	8_19824136_G_A / 8_19825034_A_G / 8_19825081_A_G / 8_19832122_T_C / 8_19823225_T_C / 8_19823468_C_T / 8_19820404_G_A	0.006249656348718163 / 9.755626466214517e-05 / 0.0032595992956769558 / 1.3994534854585697e-05 / 0.01825573585413804 / 0.0007017951945376175 / 0.0019656324021710553	0.004251571736144285 / 0.006724158153343274 / 0.02600076241538477 / 0.015595096037435119 / 0.0063513471360198154 / 0.004329630966639476 / 0.012844960200188478
634	CHAF1A_3	19_4406163_G_A / 19_4442339_C_T / 19_4422720_A_G	0.0064074940660708 / 3.653207387854824e-06 / 1.4819698101788669e-05	0.0008752119921859383 / 2.142565869765625e-07 / 0.024620616607439628
635	MDC1_2	6_30711769_A_C / 6_30704316_T_G	0.006463206071893797 / 0.0019882207404644673	0.0020262441930086923 / 0.0013599597266763966
636	DYRK1A_3	21_37420484_TGGG_T / 21_37506256_A_C / 21_37505200_T_G	0.006470184695707864 / 0.007166152604563953 / 0.0018009306683812387	0.004141112427822946 / 0.023367448843283026 / 0.006729513952629108
637	SMPDL3B_2	1_27949055_T_G / 1_27956116_T_G	0.00686332660241626 / 0.005864140422713154	0.0015905760666496795 / 0.0137996143213625
638	EVPL_2	17_76023471_A_C / 17_76023459_T_G	0.007000637494837062 / 0.0007672223327735785	0.005291001652021031 / 0.010508474240463184
639	TOM1L1_5	17_54914767_TA_T / 17_54930294_T_G / 17_54936619_A_G / 17_54936871_A_ATTAAG / 17_54949462_TAAAAG_T	0.007038383297527345 / 0.0050109411285773646 / 0.00021710780579647815 / 0.00028231096361921765 / 0.00012667235189768908	0.04878127910267323 / 0.03275406093703293 / 0.014250045450198362 / 0.01731618533169237 / 0.009468652758198769
640	PPP6R2_6	22_50437806_T_C / 22_50444323_CT_C / 22_50438097_C_G / 22_50439767_G_A / 22_50444161_G_A / 22_50435068_C_T	0.007051784222833177 / 0.023269327181446267 / 3.439001444964778e-05 / 7.581666224780631e-05 / 3.643039740627613e-05 / 0.0008291832461198612	0.0008491344323951777 / 6.519259302157606e-08 / 0.02539141451283096 / 0.0453099522882128 / 0.048741469250829166 / 0.04553862958411738
641	DAB2IP_2	9_121772524_T_G / 9_121760326_A_C	0.0070915742180131395 / 0.007778717869708281	0.02191587566106909 / 0.01751891495836218
642	WRN_8	8_31096749_C_T / 8_31124455_G_T / 8_31141606_C_T / 8_31167122_C_T / 8_31068263_T_G / 8_31096728_GT_G / 8_31081188_G_A / 8_31154721_C_G	0.0071839350828315045 / 1.9744778112725726e-06 / 3.7195190403966525e-05 / 0.0005948019596535545 / 1.4689350346055224e-05 / 0.009117602293234885 / 4.455137121499956e-06 / 0.015467137724934844	0.015593392890488516 / 0.0002318154176456728 / 0.000309347551379363 / 0.008293074145156037 / 0.01874901447901884 / 0.0010432049093381938 / 0.02919802325158393 / 0.008229549817641594
643	SEC63_2	6_107876794_A_G / 6_107876670_C_A	0.007209006342709896 / 0.0019416198580565237	0.0015670897229372802 / 0.02957724273333363
644	MAU2_6	19_19336127_G_A / 19_19338794_G_A / 19_19338877_G_T / 19_19342712_T_G / 19_19342751_C_A / 19_19344019_G_A	0.007212671514055286 / 0.000960361991019274 / 0.0009059794395416026 / 0.0008876467494768484 / 0.0008876467494768484 / 0.001002378802893851	3.528738486135461e-07 / 1.9278481053706903e-06 / 3.174590417336852e-07 / 1.942933711490239e-07 / 1.942933711490239e-07 / 3.6691446641905493e-07
645	CDCP1_3	3_45091085_A_T / 3_45091145_T_C / 3_45095296_A_G	0.007224118191596861 / 0.003521903825993761 / 7.820303910973087e-07	0.01528693636083844 / 0.0025128061409562703 / 0.034457598045182634
646	NKTR_2	3_42630618_G_C / 3_42636885_C_A	0.007397151891706983 / 0.004629789663279317	0.0027059941965995107 / 3.766470432445502e-05
647	GSN_3	9_121321305_A_C / 9_121326911_A_C / 9_121282717_C_T	0.00754758939906495 / 9.99197364773904e-05 / 0.008701863324990747	0.0036521684936499576 / 0.014858234163842209 / 0.04144642618836994
648	MTR_3	1_236885200_A_G / 1_236897645_CT_C / 1_236812798_T_G	0.007571674596968512 / 0.00019121697493807043 / 0.006559116282295972	0.013876029031175869 / 0.019195378846888603 / 0.028819324921187783
649	DNAH1_4	3_52395506_T_G / 3_52398167_T_C / 3_52375405_A_G / 3_52394972_C_A	0.007807586400497246 / 5.188940804112937e-07 / 0.028701683809333287 / 0.04830043674512241	0.020152041638368784 / 0.04601002692990365 / 0.006840623405991567 / 0.005200470677837818
650	NDUFS7_6	19_1388539_C_T / 19_1389518_C_A / 19_1390758_C_A / 19_1391101_A_C / 19_1387920_T_G / 19_1387934_A_G	0.007902298175424828 / 0.01802139597834927 / 0.005968824663343653 / 2.816150837753928e-07 / 0.0031818920109542336 / 0.02651542479567508	0.004445598304300863 / 0.004267266689815653 / 0.007929745168935362 / 0.02277060279294577 / 0.0061684138287453226 / 0.0002841985871883526
651	TLN1_4	9_35711809_G_T / 9_35712826_G_A / 9_35700530_A_AGTTT / 9_35707057_C_T	0.008212937465719947 / 4.3027034258145176e-05 / 6.892028990051384e-06 / 1.5583116688212289e-06	0.03705209858981909 / 0.019628446580987526 / 0.03215388610263167 / 0.026823292872806558
652	PARPBP_3	12_102164766_G_C / 12_102165930_A_C / 12_102195841_T_TTAAAAA	0.008239841603573375 / 0.048432585939195916 / 0.009577111829889028	9.259289657162176e-05 / 0.0008692851756599481 / 4.1069065265654646e-06
653	FZD6_2	8_103300204_A_G / 8_103318860_G_C	0.008531191339496548 / 0.00031326302687667253	0.02679919317294273 / 0.01810032651868897
654	ITPR1_10	3_4651972_C_T / 3_4673329_A_C / 3_4712028_A_G / 3_4814550_G_A / 3_4645814_T_A / 3_4652327_G_A / 3_4653996_G_A / 3_4717319_C_T / 3_4652159_T_G / 3_4516699_C_T	0.00859416859519535 / 0.0036591352908788796 / 0.002472562485621646 / 0.0007540687837519184 / 1.174056333280529e-06 / 1.6973582056331476e-05 / 0.00018073915749960563 / 0.025102582779245618 / 0.0060202139881954326 / 0.01485572695651343	0.02221500748211688 / 0.028276024726866744 / 0.031417032356405285 / 0.020003750528966732 / 0.02165052204755015 / 0.04826424992681114 / 0.04219875731949733 / 0.00956347809995603 / 0.032544122080128725 / 0.04748127629652489
655	LAMA5_11	20_62307035_T_C / 20_62308863_T_C / 20_62315711_A_C / 20_62325178_T_C / 20_62327158_G_A / 20_62327540_T_G / 20_62310033_T_G / 20_62327738_A_C / 20_62332572_T_G / 20_62327734_623	0.008632920752406494 / 0.014295751572041776 / 0.02909024968748458 / 3.555862255130917e-08 / 2.9240346346210547e-06 / 0.00712140384613043 / 1.5666190990300454e-05 / 0.019613193736301028 / 0.03355260503997278 / 0.034148373295335904 / 1.07437734215058e	0.008839994985818419 / 0.003401604212977075 / 0.0003409731985327621 / 0.010970601799299722 / 0.037454561614064526 / 0.04839717926265442 / 0.00011553533752570969 / 0.00016041497097470358 / 0.00634985461358608 / 0.00014957483336764524 / 0.02125937044218393
656	MAPRE2_2	18_35132001_G_GT / 18_35070377_A_G	0.008697538540744818 / 0.0008936827603968188	0.027950082818089944 / 0.013874344261478143
657	PCM1_14	8_17938873_A_G / 8_17938874_C_T / 8_17947156_G_A / 8_17957171_G_C / 8_17962063_C_T / 8_17962252_A_G / 8_17972247_C_CAA / 8_17993739_C_A / 8_18010736_C_A / 8_180_180A_C8A_C8A	0.008797381653836422 / 0.008797381653836422 / 8.592105380343799e-09 / 9.956680768337928e-13 / 6.195811157969624e-08 / 1.8937727055349602e-07 / 0.012906783621554044 / 0.00024859599240286334 / 0.0005752822575338514 / 1.5559989504674227-e 0.013270249004941498	0.0286880097933444 / 0.0286880097933444 / 0.005755604603604279 / 0.003664181277087841 / 0.003941798080137453 / 0.000146676782393952 / 0.003377252281952908 / 0.0004892784845984415 / 0.01725609483145887 / 0.00016889400218637822 / 0.0005696202104790463 / 5.94669308647235
658	LAMC2_2	1_183207851_G_T / 1_183207864_G_T	0.0090311817049441 / 0.0010913836051824374	0.02500420336879176 / 0.034260068788679536
659	FAT1_2	4_186706505_TAAAAAA_T / 4_186628213_A_C	0.009108698459398929 / 0.008101657943453211	0.02585265305545377 / 0.01860566173117391
660	SQSTM1_3	5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C	0.0096926694417795 / 0.004856219591816439 / 0.0277352874184494	0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784
661	CCDC25_3	8_27736133_T_C / 8_27740525_GA_G / 8_27740655_A_G	0.009721303652590912 / 0.0012870249285031976 / 0.019736174159448082	0.012214514779241077 / 3.013644227200994e-08 / 0.009242113446549792
662	PTGFRN_2	1_116949272_C_G / 1_116985006_T_C	0.009786238032301352 / 0.0007152254747991232	0.04386987327886 / 0.015007302908998025
663	CUEDC1_2	17_57872703_C_T / 17_57873465_G_A	0.010263213673294223 / 0.0029406902030506186	0.0013582824059236026 / 0.00965828204249475
664	POLR3D_5	8_22247989_T_C / 8_22247116_G_A / 8_22247770_T_C / 8_22250473_A_G / 8_22245170_T_G	0.010361813952662016 / 0.040760845043798406 / 0.010265363996485286 / 0.010265363996485286 / 0.03202227743017228	0.0015081231813274575 / 0.0005996811951877831 / 0.0014851724380103976 / 0.0014851724380103976 / 0.0034846025589736784
665	MDN1_10	6_89661483_G_A / 6_89662267_C_T / 6_89680724_C_A / 6_89712908_G_C / 6_89728912_G_T / 6_89745710_T_C / 6_89819438_A_G / 6_89819440_C_G / 6_89819446_A_G / 6_89656810T	0.011142557737209857 / 0.019733545814518076 / 0.00671054318104286 / 0.009319633314546674 / 0.029067614736169964 / 0.014718502010945343 / 0.03726926768860217 / 4.658109373380921e-05 / 0.00043794075690144836 / 0.001077236984005633	8.702195141061847e-05 / 4.241840867716095e-05 / 3.792323014139115e-05 / 0.002381685713249437 / 0.003051989681616468 / 0.0024784505977437274 / 0.002315253787970113 / 0.00030565312846269634 / 0.0005358395597195241 / 0.045388379703494304
666	ZNF407_5	18_74635526_T_C / 18_74881076_C_G / 18_74881080_A_C / 18_75064165_G_A / 18_74881141_G_A	0.01132130975657727 / 0.03691411059827635 / 0.002564188916256107 / 0.00027018930993972406 / 0.0024107982547803396	0.0030145474545959137 / 0.009890224680183182 / 0.03975077518004473 / 0.0037574487440396095 / 0.018926593122392126
667	C18orf21_2	18_35977490_T_C / 18_35973023_A_G	0.011570265284110644 / 0.04350573719131977	8.814319140246499e-05 / 0.009001638536085271
668	DNHD1_2	11_6566998_G_A / 11_6502909_T_C	0.01157615377505105 / 0.024706472106323003	0.003441011845932656 / 0.0051368432267910715
669	KCNQ5_2	6_72622312_C_G / 6_73194868_A_C	0.011667048329227513 / 0.008556892857902195	0.005821769162034106 / 0.002035847347947271
670	USP7_3	16_8916969_T_TA / 16_8921401_T_C / 16_8919178_A_G	0.011921515809972538 / 0.0007259106255980508 / 0.00985787434616614	0.007935686984078177 / 0.03489258945527392 / 0.01271404693174776
671	KRT19_2	17_41524128_T_G / 17_41524420_C_T	0.012145831162385651 / 0.02329208372328466	0.006794604788851329 / 0.0075159453943370955
672	CHD4_2	12_6598281_A_C / 12_6596093_T_C	0.0122076861217219 / 0.004382346617449564	0.0023450404288739924 / 0.005341196474657028
673	TRIO_5	5_14270972_A_C / 5_14380924_T_A / 5_14287139_AT_A / 5_14485052_GTTTT_G / 5_14304660_GA_G	0.01228372579415868 / 3.324291735916414e-05 / 0.01866091088461598 / 0.0021188750196952637 / 0.001000539371629746	0.0041763005884629285 / 0.009266068007448034 / 4.1269944199248776e-05 / 0.00011802420018250479 / 0.0066869864395857175
674	NR2F6_3	19_17232488_A_G / 19_17240807_T_C / 19_17240813_T_C	0.012426826069594731 / 0.008405600723765323 / 0.0104569397340928	0.0005711072972571918 / 0.006907234943082266 / 1.728226736131038e-05
675	HNRNPH1_2	5_179621204_T_C / 5_179614784_GAAAAA_G	0.012466319116509934 / 0.03611121611218025	0.0008981889773064157 / 0.009729395921872941
676	POLDIP3_2	22_42585672_T_C / 22_42585502_A_C	0.012811765150489051 / 0.04394982419601543	3.6252104008481515e-06 / 0.004353728585767742
677	CASKIN2_4	17_75501358_G_A / 17_75501713_T_C / 17_75503616_T_C / 17_75508335_T_C	0.01313679969802845 / 0.0005650477736965628 / 0.0014275310574789414 / 0.004128633364054907	0.002427426610400476 / 0.00023272703416067725 / 0.00689117538932749 / 0.024705224854909082
678	ZNF557_3	19_7083618_A_G / 19_7083750_A_G / 19_7074861_G_A	0.014332802500416091 / 0.016198364111666076 / 0.009991664044269358	1.6329734686551152e-07 / 4.640996358288638e-07 / 0.019872633283012617
679	BPTF_2	17_67825365_C_T / 17_67911547_C_G	0.01437455334956587 / 0.027807620738219758	2.5754103071800682e-05 / 0.006958200054189394
680	UGGT2_3	13_95833163_A_G / 13_95853698_T_C / 13_95860933_T_C	0.015116310313098947 / 0.037400522782126695 / 0.007496186466991611	0.000224596103770692 / 0.0011686091908779301 / 0.002068524896740717
681	FNDC3B_3	3_172362611_AT_A / 3_172328905_GT_G / 3_172286041_CTTTT_C	0.015509630370521969 / 0.002266663581871069 / 0.0003779941256659541	0.0007669696976411361 / 1.7757436099968484e-05 / 0.031871180713847265
682	CLIP1_3	12_122328152_A_C / 12_122328157_C_T / 12_122328162_C_T	0.01554438347868009 / 0.004768276278894758 / 0.002667521200669866	0.002481037749459045 / 0.041472618812521435 / 0.048511002649469816
683	TNKS_6	8_9680125_G_A / 8_9720284_A_AT / 8_9720294_C_A / 8_9735571_A_C / 8_9751720_A_C / 8_9766458_A_C	0.015553063070783985 / 0.021640953132470588 / 0.009525586921605824 / 0.006640140033620625 / 0.006977786341777385 / 0.032727629530903864	1.1196019412041484e-09 / 6.428366457977679e-07 / 9.234432766615335e-08 / 4.809045747636942e-06 / 0.019396751254115357 / 9.650265166072016e-07
684	NAA15_2	4_139349721_G_A / 4_139349435_AT_A	0.01573160679440035 / 0.003429044586968857	0.0002098904518747522 / 0.002911064627846368
685	RANBP3_5	19_5928023_T_G / 19_5928174_T_C / 19_5915583_A_G / 19_5925847_A_C / 19_5978199_C_T	0.01583040778996785 / 4.474815722770587e-05 / 5.7769976083466666e-05 / 0.0026896515436457035 / 0.007526230369901563	0.009045897483820205 / 0.0004179910655369823 / 0.03657225828634877 / 0.013386174688145538 / 0.043887995871297616
686	CCP110_6	16_19536035_A_G / 16_19536181_C_T / 16_19545945_C_T / 16_19541861_T_C / 16_19536052_C_A / 16_19548016_T_G	0.016159655378318708 / 0.04502177918333454 / 0.008022125809200288 / 4.851993209582035e-06 / 0.0004153878057481152 / 0.025513237898367132	0.00016378049017362915 / 0.0005567133937571787 / 0.0006179187799490345 / 0.015929257083152543 / 0.0007996357401027085 / 0.009536820248258198
687	ANXA11_2	10_80166029_C_T / 10_80161797_T_C	0.016605419991514502 / 0.0051164435438795204	0.007800123858178394 / 0.0013053025194313356
688	PLEC_5	8_143935900_T_G / 8_143916360_A_G / 8_143918739_A_C / 8_143929244_A_C / 8_143934289_T_G	0.01665471808934805 / 0.0034243187807631525 / 0.0018067465091272969 / 0.0008521926558447601 / 0.0001319263889148404	0.0004960012901022363 / 0.00910116635228719 / 2.138708286444241e-05 / 0.04249632659180479 / 0.008202162742211878
689	PDHB_5	3_58429863_C_A / 3_58427942_G_T / 3_58430808_C_T / 3_58431043_T_TTTA / 3_58431689_C_T	0.016694590509161198 / 0.0034915452482365546 / 0.0014468501934601355 / 0.00012132584593612988 / 0.0014468501934601355	1.9636106867401007e-06 / 9.607912469556515e-06 / 1.1215690852590127e-06 / 4.480434017438887e-06 / 1.1215690852590127e-06
690	ABHD12_3	20_25307869_C_T / 20_25297964_G_A / 20_25301097_T_C	0.017594886478281925 / 0.043687457267011516 / 0.004129132243776882	8.56668297363822e-06 / 0.00227969505884927 / 0.0004270759204191932
691	TRAPPC8_10	18_31858057_A_C / 18_31913653_A_G / 18_31900873_G_A / 18_31900876_C_A / 18_31867505_T_G / 18_31907633_T_A / 18_31846589_A_C / 18_31871211_T_A / 18_31901115_GT_G / 18_31858058	0.01811627325789324 / 0.0017149077087971164 / 0.007882909715425471 / 0.0003097530865800165 / 0.0017696529343949547 / 0.003408008625421304 / 0.0025767772792916893 / 0.020052128513604172 / 0.0014872998913138286 / 0.009626844127190594	0.006180390175955454 / 0.009898646981541573 / 3.5402082656175115e-05 / 2.004341589623153e-05 / 0.00036773660587014015 / 0.0008596942505949141 / 0.0019258630221215085 / 0.0005317253240119541 / 0.03754796616685669 / 0.003048367023556882
692	NARF_2	17_82488071_A_G / 17_82485433_G_A	0.018611831902577654 / 0.0032741374426950077	0.0015678226483248074 / 0.03776328708562675
693	RPL9_3	4_39454772_G_A / 4_39458104_T_C / 4_39457622_A_G	0.01872028096022281 / 0.038040018913816906 / 0.013766563241610607	0.004161577416808298 / 0.004570198384291764 / 4.793806278603332e-07
694	SENP7_2	3_101347873_T_A / 3_101513249_C_A	0.01892010828896953 / 0.027162288974149237	4.432034386075619e-05 / 0.00843965290168897
695	HERC1_4	15_63666001_A_C / 15_63666004_T_C / 15_63754569_A_C / 15_63706823_T_C	0.018947416114520832 / 0.012801946597404643 / 0.009094911651776984 / 0.0001905333488051304	0.0009552551098417773 / 0.0050390069990103115 / 0.007343118479360836 / 0.005050957906342418
696	DOCK11_2	X_118627539_A_C / X_118580020_T_G	0.019238892996198773 / 0.002446966159681028	0.00012436903410890539 / 0.02379391735060052
697	KLF5_3	13_73063987_G_T / 13_73062772_A_AGTGT / 13_73063986_TG_T	0.019354403860496208 / 0.037567154465037694 / 0.006314572274949971	0.008502737493358522 / 0.0008455054702052634 / 0.045197394376435635
698	FERMT1_2	20_6119441_A_G / 20_6076305_T_G	0.01953104506649206 / 1.5328575507414378e-05	0.003951008923557318 / 0.005589077504505465
699	CGGBP1_2	3_88056114_A_C / 3_88058700_T_G	0.019690640293771062 / 0.0001488078729312028	0.0013325718879930134 / 7.124415972693971e-06
700	CEP85L_4	6_118511157_T_C / 6_118565452_T_C / 6_118565798_G_T / 6_118652790_A_G	0.019951442705337254 / 3.4006295145334306e-05 / 0.006640489210238536 / 0.005690521125333515	0.0019936945989450267 / 0.031500707148776626 / 0.011376444437361329 / 0.01248838915032558
701	TCF4_7	18_55585157_G_A / 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55403517_A_C / 18_55461237_G_T / 18_55234488_T_G	0.02005132938992895 / 9.139603483849228e-07 / 0.003907248287482544 / 0.04979553061082194 / 0.027277557605803925 / 0.004036463102105114 / 0.0005592100190603741	0.002362550141751555 / 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 1.5397131093463103e-06 / 0.04572000946513434 / 0.005926553123167896
702	DQX1_2	2_74518953_C_T / 2_74519195_A_T	0.02016550460713128 / 0.02345411840768387	0.001543466936969916 / 0.0012259823356569838
703	UBR5_3	8_102327653_A_C / 8_102288240_T_C / 8_102311353_A_G	0.02158342295983112 / 0.000182245886028422 / 0.002891650419980013	0.0014448817758050778 / 0.041616237854309936 / 0.00926532742682097
704	UBR7_2	14_93227076_C_T / 14_93227060_C_A	0.021764228343538142 / 0.00036547494521639036	5.580051554471299e-12 / 0.004489348973894868
705	PRDM15_6	21_41804523_A_G / 21_41857170_C_CT / 21_41878737_C_T / 21_41878845_C_CG / 21_41879218_C_A / 21_41860296_C_G	0.022209828018085867 / 0.0016831430872538335 / 0.001963497325920565 / 4.181886700329235e-07 / 0.0008539747138144563 / 0.003762939149636617	0.0024789131706555692 / 0.04559041805735448 / 0.004333100546220035 / 0.0014981405701937028 / 0.007033127481264185 / 0.003918924565748825
706	HPS4_3	22_26464303_G_C / 22_26466187_C_A / 22_26466246_T_C	0.023338960947810374 / 0.0034082024391394804 / 0.008599880725164986	0.00049975228288003 / 0.013660798942983977 / 0.013660798942983977
707	KIF13A_2	6_17759921_G_T / 6_17779691_GA_G	0.02351576585497226 / 0.0016700241845674759	0.005082432403932738 / 0.03874282920193672
708	SLC35B4_8	7_134294793_A_T / 7_134294800_C_T / 7_134294826_A_G / 7_134295043_T_C / 7_134296475_G_A / 7_134299375_A_G / 7_134300126_G_A / 7_134304791_A_G	0.02373113198705864 / 0.01698627709999008 / 0.006372984518535906 / 0.02196618128109366 / 0.0003440877501955943 / 0.006567115319239084 / 3.4006295145334306e-05 / 0.005046500727253695	0.007700956159853255 / 0.0033988992551489622 / 0.003846947305778054 / 0.003846947305778054 / 0.0005322435434420271 / 0.004732359355015072 / 0.00026123770283039777 / 0.0007109966209961128
709	L3MBTL2_6	22_41213686_C_T / 22_41221314_G_C / 22_41217184_C_T / 22_41217299_C_T / 22_41221156_T_TG / 22_41214238_A_G	0.02384699817673188 / 0.036506965435244586 / 0.00046243520821700383 / 0.0014542660494230402 / 0.0048712846790899276 / 0.009223190722677185	0.0010787186334203051 / 0.0001832674707524145 / 0.0038205423576211455 / 0.004209694792725524 / 4.2157738222413464e-06 / 0.04965109007915304
710	RAI14_6	5_34810866_G_A / 5_34811689_T_C / 5_34812303_A_G / 5_34812384_A_G / 5_34814795_A_G / 5_34826376_A_C	0.02398248389974741 / 0.003021738485801497 / 0.03016889098915158 / 0.04699754955019005 / 0.007276272312251042 / 0.03015590631046501	0.005930385895234786 / 0.02067007422009637 / 0.008963944637711066 / 0.0075054618188784596 / 0.002646842318515723 / 0.006485048570616563
711	ARHGEF10L_2	1_17632421_T_G / 1_17581112_C_T	0.02441616386812752 / 0.008405600723765323	0.00740919250255517 / 0.019746113249432044
712	WFS1_2	4_6300580_T_G / 4_6301666_T_G	0.024665242803626187 / 0.008957131401361508	0.0005139212842413073 / 0.005931412638336574
713	TPP2_5	13_102645085_CT_C / 13_102649187_G_T / 13_102629949_C_G / 13_102634223_C_T / 13_102645085_CTT_C	0.024741402723073853 / 0.028415295283801194 / 0.001061432461116305 / 0.03296472481201721 / 0.00032041277623460525	0.0017617933204615989 / 0.0003388682906380855 / 2.491492385425685e-05 / 0.0010859815068279958 / 0.04128722708381896
714	DPY19L3_3	19_32480317_C_T / 19_32482171_C_T / 19_32457979_A_AT	0.02575962131883935 / 0.041529928834727996 / 8.068330723796263e-08	0.00488668851811109 / 0.00656763144792808 / 0.0003669711749463792
715	SYNE1_13	6_152149487_A_G / 6_152310394_A_C / 6_152302141_A_G / 6_152350340_A_C / 6_152350418_A_G / 6_152350784_G_GA / 6_152350840_A_G / 6_152354719_A_G / 6_152373049_T_C / 6_152_C 6_152G_	0.02589202251594358 / 0.0068225672761204 / 0.018111885168250186 / 0.001534088782688901 / 0.00015349542079229654 / 0.003947934300958396 / 0.009039115199453142 / 0.0032281218393380826 / 0.034085027891066176 / 0.0074217808535962425 / 0.0003084243419514754 / 0.04013949092531816942	0.0022312687521415984 / 0.000300569048618415 / 0.000916091757381376 / 0.04334315784101184 / 0.025133645776259043 / 0.015037738599618973 / 0.049886685026608805 / 0.04777964311542563 / 0.003302156741579197 / 0.012499408296212235 / 0.002950466518563372949 / 0.0028434342
716	BAIAP2L1_2	7_98312162_T_G / 7_98310492_T_G	0.02645273506751201 / 0.017881464475754172	0.002108350377110309 / 3.1631490207583316e-05
717	CXXC1_4	18_50283881_C_G / 18_50283981_A_G / 18_50282775_A_C / 18_50285505_A_G	0.02700492420991353 / 0.00030830634455756233 / 0.00020363998830215009 / 0.024668590953954232	0.0054045514118498715 / 0.0069760254674185035 / 0.00041677651706905364 / 1.2396826716404366e-06
718	ITGB5_3	3_124769064_T_G / 3_124796789_C_T / 3_124809087_T_G	0.027271474201973192 / 0.0030628908663900517 / 0.02459057498205289	0.0006588536356118503 / 0.03655295537599197 / 5.4585187494895796e-05
719	BRD4_2	19_15255220_T_G / 19_15264730_T_G	0.02738257500091704 / 0.0024688743871748233	0.003128882089479218 / 0.012931811845921107
720	TUBGCP6_3	22_50218683_C_T / 22_50226183_A_G / 22_50216669_A_G	0.02873848846989375 / 1.7193787546395546e-05 / 0.001425645880342349	0.0032493001194240914 / 0.004608803965780261 / 0.0053976890998902035
721	SH2D4A_2	8_19373444_G_GTA / 8_19373444_G_A	0.029078590360841292 / 0.0012205889084294006	0.0029847738366696104 / 0.03439931765423256
722	UPP1_3	7_48088999_G_A / 7_48108129_C_G / 7_48108147_T_G	0.029144965782620207 / 0.015833254501378846 / 0.01682115524692246	0.0003765748447247093 / 0.0002337913556195707 / 0.0015081620173450355
723	WDR48_5	3_39068755_C_T / 3_39069649_C_A / 3_39066494_T_A / 3_39077046_G_A / 3_39052175_T_A	0.030420442989910295 / 0.044145461001922535 / 5.492585713676155e-05 / 0.00014207366024108895 / 0.015418219237359813	0.00013091692663621323 / 1.1291180538837308e-09 / 0.030704581537927867 / 0.04365312343408456 / 0.002516254064872987
724	PDS5B_5	13_32741072_A_T / 13_32758091_C_T / 13_32675925_C_A / 13_32710010_G_T / 13_32652145_GT_G	0.030726392282429425 / 0.00123879071402958 / 0.0006856670147522433 / 0.002121608222392312 / 0.0007921211551638221	0.001639201016530517 / 0.0023301391981286807 / 0.004241708828197667 / 0.017388913859398773 / 0.002787725341881676
725	AHNAK2_13	14_104948863_G_C / 14_104950348_C_G / 14_104952007_T_G / 14_104952054_C_T / 14_104954590_A_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950948_C_T / 14_104946565_A_C / 14_104_104_104G_14_10494	0.0308328381135858 / 0.016748316074642184 / 0.03839823545317707 / 0.03874915731384604 / 0.0072096008154851265 / 1.5768275144985015e-05 / 0.006402387188591212 / 0.006209224175079767 / 0.02197650841839336 / 0.005813098445302893 / 0.024214266407806717 / 0.0185888935	0.0037872773041585602 / 0.0010008042001551844 / 4.242877237542688e-05 / 4.758634079373864e-05 / 0.044213954062984784 / 0.00506490504122054 / 0.005256944789299486 / 0.009057439080581924 / 0.006657596405885244 / 0.015474300784924832 / 0.00350031652733231949
726	PSIP1_4	9_15469426_TA_T / 9_15472613_GA_G / 9_15478664_T_C / 9_15473904_C_CA	0.03090002089985741 / 0.010885733995064931 / 0.0036412739882121493 / 0.019522544533840024	0.0021167351616768765 / 0.002781333210996778 / 0.04454350703768868 / 0.047598542315053116
727	ANK3_2	10_60140286_C_G / 10_60140292_G_T	0.031415751059474716 / 0.004915637551152243	0.006334167714527676 / 0.025015110862319518
728	PLEK_3	2_68380987_A_C / 2_68388306_A_G / 2_68380161_C_G	0.0317726416239668 / 0.008640427676032429 / 0.003025481684231003	0.0018651167043750433 / 0.012112306050675708 / 0.004442991541746456
729	HMGB1_2	13_30463652_C_G / 13_30465849_T_C	0.03226480417721332 / 0.0001648093940653516	0.0005823170484383475 / 1.5385023502599213e-07
730	ACTN1_2	14_68890121_A_G / 14_68904620_A_G	0.032894585296185316 / 0.002540635063275344	0.0030504600602986385 / 0.01924890787722053
731	FAM193A_2	4_2662705_A_G / 4_2659865_A_C	0.033419216681695084 / 0.04113816735227994	0.006119225115333783 / 0.002421422710409682
732	ALS2CL_3	3_46688267_C_G / 3_46671861_C_A / 3_46683906_C_A	0.03379224538431711 / 2.315014453759593e-05 / 0.005940717099935289	0.0010458636942191153 / 0.016517080453509674 / 0.048512125386189216
733	SMARCA5_3	4_143521582_C_T / 4_143514027_G_A / 4_143513907_T_G	0.03389913212461259 / 0.0005336701932334038 / 0.00047650766195259835	0.009752627346239709 / 0.0006586181076668231 / 0.004556295949163353
734	TMBIM1_4	2_218278506_G_A / 2_218278604_T_C / 2_218279426_G_A / 2_218282145_T_C	0.03396031249525595 / 0.02844679337110864 / 0.0068961961974542295 / 0.0018492744109954121	0.002273449490648745 / 0.0012042001777173455 / 0.0022480783740468167 / 0.030530266212098117
735	ZNF236_5	18_76959812_T_C / 18_76968158_T_C / 18_76968252_C_T / 18_76936580_G_T / 18_76968514_A_G	0.034863364756142684 / 0.00544264119615534 / 0.007385442293655849 / 1.258127500782992e-05 / 0.001396157570840323	0.004671655781344212 / 3.359123080186937e-06 / 3.816383122507129e-05 / 2.2508576141383803e-05 / 0.00014020410621502926
736	DMAP1_3	1_44213884_A_G / 1_44219323_T_C / 1_44214487_A_C	0.03508585380179657 / 0.0001543183975019544 / 0.000996146741984629	2.797176359518221e-05 / 0.04898236049763705 / 0.041077293102317024
737	GIT2_2	12_109951210_A_C / 12_109952676_A_C	0.038020170939281527 / 0.044654978525331915	0.0015711134341594402 / 0.0073535263645836966
738	PBRM1_4	3_52642049_CA_C / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C	0.03826328245790342 / 0.003417708183485354 / 0.003417708183485354 / 0.004371631368875628	0.0014123627803440367 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218
739	SEMA4B_3	15_90230550_C_T / 15_90219735_T_G / 15_90223369_T_C	0.0382907038385724 / 0.00014017436078508742 / 0.003606528003523896	0.003576989974401659 / 0.0196110620734337 / 0.012423711849739305
740	CDH1_2	16_68823310_T_G / 16_68810107_C_G	0.03866739925480673 / 2.3568872507011226e-05	0.0025541666878341144 / 0.0045199561560194616
741	PAK4_3	19_39176740_T_C / 19_39178411_T_C / 19_39178960_A_ATG	0.03964657176847531 / 0.0031968419187330646 / 0.00031366512220605466	0.0005253339462112416 / 0.012050619287225093 / 0.04112372072532399
742	KDM5A_2	12_310904_G_A / 12_323658_C_A	0.040083104628847975 / 0.03485434053230182	8.99232571405919e-08 / 4.775460326696479e-06
743	CHMP7_4	8_23249152_A_G / 8_23260130_T_C / 8_23260642_T_C / 8_23255149_C_T	0.040858161657175214 / 0.0021955959993491484 / 0.001347026932454516 / 0.005979199546716722	0.00985156252549634 / 0.007951126415472621 / 0.005852678740537498 / 2.528028640474925e-05
744	FASTKD1_2	2_169557305_CA_C / 2_169557305_CAA_C	0.04142328785089491 / 0.016746895905411573	0.00016945881737810868 / 0.003864236188058555
745	MRPL39_5	21_25587877_T_G / 21_25588774_T_C / 21_25594005_A_G / 21_25603938_A_G / 21_25607316_G_A	0.04194490101459973 / 0.01937493996228174 / 0.01845646940649424 / 0.02800309093409305 / 0.00630118834188515	5.7418126731545284e-08 / 3.6929628125728576e-08 / 2.5701269842959545e-08 / 1.0577675519010665e-08 / 3.688861166466308e-08
746	PON2_2	7_95406313_A_C / 7_95406317_T_C	0.04295809677939748 / 0.03518057074232925	9.367508145310504e-06 / 9.041805671182428e-07
747	ATP9A_2	20_51608625_A_C / 20_51627544_T_G	0.0453107586125816 / 0.0033064577154371753	0.0016205979394364285 / 0.046011362965187
748	SYNE2_3	14_64189964_AT_A / 14_64022731_CT_C / 14_64122119_G_A	0.04554515566635235 / 0.0259958042872378 / 0.005029743152006167	6.34029580306576e-05 / 0.003556496243260812 / 0.031891035954103614
749	EXD2_2	14_69236592_C_T / 14_69236597_G_T	0.045815872520569866 / 0.007261223228798206	0.006743325380355538 / 0.009984452523516405
750	USP22_9	17_21002832_G_C / 17_21002938_C_T / 17_21002944_A_G / 17_21005012_T_C / 17_21018179_C_T / 17_21021210_G_A / 17_21021307_T_C / 17_21028347_G_T / 17_21043080_T_C	0.04602479247359704 / 0.008276359973551 / 0.0003145539245206166 / 0.00013159988064048868 / 0.00017641068386537028 / 0.00018037842009303046 / 0.002766843921558569 / 0.00965100020152009 / 0.0021915580128042123	5.2405530742318296e-05 / 0.0001522332352001979 / 0.0010200867803667195 / 0.0002608036035294038 / 0.0002258154609608441 / 0.00012857609143244398 / 4.777859944106238e-06 / 0.001140393407840919 / 0.01642994041963463
751	R3HDM1_2	2_135621624_GT_G / 2_135661361_A_C	0.04643229751040803 / 0.01096218490346052	0.007933574405897037 / 0.00075038338644858
752	LAIR1_2	19_54364274_T_C / 19_54364717_T_C	0.04672350230262375 / 0.015465209925053043	0.008257714587898193 / 0.006617848488520711
753	EVL_5	14_100126634_T_G / 14_100132827_G_A / 14_100126622_G_A / 14_100132645_T_G / 14_100135917_A_C	0.047372429474904484 / 0.0016660544745078804 / 0.004134369004838065 / 0.00016640135361204822 / 0.0031029134247096963	4.756430435799507e-06 / 0.00563219201718044 / 0.01997007957497231 / 0.026704266687616097 / 0.006469582595095918
754	RNF123_2	3_49714152_C_T / 3_49700145_G_T	0.047756940070976237 / 1.1366734297895966e-06	0.00816572334990732 / 0.0037608177292696564
755	DNMT1_2	19_10162649_G_A / 19_10143809_G_C	0.04804143143713783 / 0.022663915935835485	0.0013474327860987167 / 0.0054179883970128856
756	BTBD16_4	10_122275013_G_T / 10_122275188_T_C / 10_122285973_C_T / 10_122291060_G_A	0.04876523124872777 / 0.04476796806488366 / 0.00874169822078938 / 0.03049550442980961	0.0003520007001970831 / 0.00020893956494733148 / 0.0013169765604353282 / 0.0026073441109972398
757	FUCA2_2	6_143504166_C_A / 6_143507227_A_G	0.049200639651661375 / 0.029895339238934462	0.00639339868461808 / 0.0054745403112583324
758	PPIP5K2_3	5_103201499_T_G / 5_103201584_A_G / 5_103201656_T_C	0.04957254295359858 / 0.00015517194478671765 / 9.016600091479696e-05	0.00015030812167049831 / 0.020151832289907558 / 0.029631285544831236
759	TIMM44_3	19_7932571_A_G / 19_7932574_T_G / 19_7932577_T_G	1.3167297251695571e-05 / 0.0003422957438462025 / 0.0005904858316322034	0.02845639919448445 / 0.006688970144575634 / 0.006057634937627619
760	MEX3C_2	18_51196847_C_T / 18_51196775_CGCCGCCGCG_C	1.329885109524148e-10 / 0.0022225090338153708	5.249784413332885e-07 / 0.01963887463995091
761	MTUS1_3	8_17754377_G_A / 8_17755366_A_G / 8_17721812_A_C	1.3576985363683765e-05 / 1.972258766974004e-08 / 0.02629101974751153	0.001701316781434502 / 0.026616233857667596 / 0.002181030051469235
762	CTSH_2	15_78922969_A_C / 15_78939184_A_AG	1.4037598311677378e-05 / 0.0001924278188105154	0.010345021977573308 / 0.0344244477250216
763	IL18_3	11_112150193_T_G / 11_112155193_G_C / 11_112155192_T_C	1.461260124702572e-05 / 7.96641505141555e-07 / 0.03134154150698633	0.012472744364369587 / 0.011978242096605442 / 0.007248539214372238
764	ZNF654_2	3_88139270_G_A / 3_88140191_T_C	1.4751691487034687e-06 / 2.0819038805248358e-07	0.0018019171147236148 / 0.0019048877551503765
765	ZNF589_6	3_48241161_TGCGC_T / 3_48241205_A_G / 3_48257949_T_C / 3_48268338_C_G / 3_48286239_T_C / 3_48286261_G_A	1.6889590876869102e-06 / 1.1715920482680521e-06 / 7.920379942105592e-05 / 2.8491798121821795e-05 / 1.5027613326502343e-05 / 7.796162715352446e-06	0.0007986098597650371 / 0.0010457901523321454 / 4.006095509659407e-05 / 0.0020191705610664206 / 0.001627877596998014 / 0.0011919391649323414
766	EPS15_6	1_51361249_T_C / 1_51405766_G_GACTC / 1_51440277_CTGTG_C / 1_51463832_TA_T / 1_51472751_T_G / 1_51461237_G_A	1.6925862398730225e-06 / 4.1443509369940415e-05 / 0.031894015484001656 / 3.0950467922083264e-06 / 0.02951071302033457 / 0.01032478965873057	0.0002615744055786565 / 0.0005725418098281438 / 0.00017362501014406024 / 0.0002615744055786565 / 0.0045422702652321255 / 0.0029577065864897127
767	ZNF266_2	19_9413509_A_G / 19_9420011_TG_T	1.7177250175637761e-06 / 0.04040969628183889	2.6110373221371133e-14 / 0.004948136499581445
768	BCAM_2	19_44820881_G_A / 19_44811510_C_T	1.7938533698319987e-05 / 0.0006276370995178965	0.006588412083819078 / 0.021875016141096045
769	C3orf38_3	3_88150029_T_C / 3_88150035_T_TC / 3_88150148_T_C	1.7996666116084316e-06 / 0.00014178936922186315 / 2.595905755446793e-06	6.57647003118834e-05 / 4.649030455483649e-05 / 7.105213671060247e-05
770	ERICH1_8	8_659132_C_G / 8_657766_C_G / 8_658018_C_T / 8_666590_T_A / 8_673593_G_A / 8_715858_C_T / 8_659879_A_C / 8_659039_G_A	1.8121573621263876e-05 / 0.0010420319235614432 / 0.04660176454698252 / 0.004834244365989843 / 0.007260620745344446 / 0.04859602375702362 / 0.0025352106440479803 / 0.002455544576447661	0.0054140514901705895 / 0.043640948824396286 / 0.0013028832620993098 / 0.018154111038570942 / 0.01865482112843118 / 0.00034437810537597347 / 0.0461414202945825 / 0.014420687330437538
771	LSR_2	19_35267372_G_GGGA / 19_35267177_A_C	1.823380047726112e-06 / 0.03651632235421607	0.0021105674130373147 / 0.0028831204631532326
772	PIK3C3_3	18_41955191_C_G / 18_41955194_A_G / 18_42043978_A_G	1.9440372522869497e-06 / 0.0006320335833085862 / 0.023735103370508225	1.065744821934887e-06 / 0.0001342557450694381 / 0.00031280032152652704
773	TAF3_4	10_7824594_T_C / 10_8013652_G_C / 10_8013913_G_A / 10_8014532_C_T	2.0664435570944493e-05 / 0.004655883072306037 / 0.00943383216960874 / 0.0009463104379838767	0.03748233778862958 / 0.008249411816346357 / 0.004857051949006447 / 0.0014732747867095904
774	FNBP1_2	9_129909080_T_TG / 9_129923982_A_G	2.1184979283245958e-05 / 5.268485267589101e-05	0.013989753243576588 / 0.019443664939858312
775	SACM1L_14	3_45719623_G_C / 3_45722143_A_G / 3_45722754_A_G / 3_45723052_T_C / 3_45731250_T_C / 3_45731280_G_A / 3_45732240_G_A / 3_45737644_A_T / 3_45705344_A_G / 3_45__A_G_3_45_45	2.2026676208492585e-06 / 9.443816831049491e-07 / 0.0022018800476893614 / 3.5837125763699036e-08 / 4.4397997289151143e-07 / 1.2227532248856571e-06 / 1.3468374724431254e-06 / 7.150800554712763e-07 / 0.013551678428059705 / 0.00535 899	2.7990310927885382e-05 / 2.6591646486392756e-05 / 0.006779520290921261 / 3.962907852818685e-05 / 1.1237814806460453e-05 / 4.359294069545172e-05 / 5.1558332133000766e-05 / 3.496973226569382e-05 / 0.0006684767742569695 / 7.3024370058 / 0.03994336344384322 / 5.7399601602553275e-06
776	TXNL1_3	18_56602813_A_T / 18_56626612_C_T / 18_56651278_A_T	2.210469276189849e-06 / 0.022001595468935316 / 0.02149358538709261	4.0417773765221675e-09 / 2.767068005468822e-10 / 1.7102012334179478e-05
777	PTPN3_2	9_109436866_A_G / 9_109406452_T_G	2.248398882883789e-05 / 0.008436388558613016	0.022560149794550868 / 0.025748841495573487
778	LAMA3_9	18_23861753_C_T / 18_23915519_T_C / 18_23946123_C_T / 18_23949758_G_A / 18_23954737_C_A / 18_23954739_C_T / 18_23939340_A_C / 18_23713905_CT_C / 18_23846109_T_G	2.2546401848550504e-07 / 0.0006963202810397933 / 1.582829210028338e-05 / 1.6534066895813288e-06 / 2.6769400746243374e-05 / 1.9933398900670928e-05 / 0.0008881294144847822 / 3.0126882423530804e-05 / 3.5426816292959363e-05	0.033914720695717084 / 0.013114315448110179 / 0.03066224880164858 / 0.025703076793439833 / 0.042551605063568684 / 0.030472466536971138 / 0.013225085724631118 / 0.01613050085470659 / 0.04009682047166014
779	MTMR9_3	8_11284836_T_G / 8_11309724_G_A / 8_11322815_A_C	2.349458678158868e-06 / 0.0004653758499732343 / 0.008022838484344897	2.4088220462781546e-11 / 0.0074905636429132404 / 0.008917788804222488
780	ITGA6_4	2_172427981_A_G / 2_172427985_C_T / 2_172484735_A_G / 2_172490965_G_T	2.55642040821661e-05 / 1.1751587238624405e-05 / 0.002854965230943433 / 0.025550057038402886	0.021886276374067117 / 0.023752544661456654 / 5.351259734935356e-06 / 0.007174810273459709
781	KRI1_8	19_10557707_T_C / 19_10558277_G_A / 19_10560316_C_T / 19_10565667_A_T / 19_10565747_G_A / 19_10561817_C_T / 19_10562664_C_T / 19_10565811_G_GCC	2.6474598014609052e-05 / 9.523794655306364e-05 / 0.00011786607794266038 / 0.0001616270444439651 / 3.4012624242046115e-05 / 1.477271100442178e-06 / 1.0798436673597302e-06 / 6.316959826240111e-06	0.00012897741560140272 / 3.792910022705542e-05 / 2.0569928046658807e-05 / 2.711645177509063e-07 / 3.211054485740389e-07 / 1.8153836897508705e-05 / 0.0002329401807770252 / 0.0008450486067550477
782	GBP3_2	1_89007941_G_A / 1_89011034_A_T	2.713567196210831e-05 / 0.047917709012617486	1.221534419837023e-06 / 2.259902209453749e-08
783	FGFR2_2	10_121487530_T_C / 10_121520352_C_T	2.796050535454376e-05 / 9.346629403777272e-05	0.015364585786772819 / 0.004955596968571121
784	TNRC6C_2	17_78049826_A_C / 17_78067796_A_G	2.865420177578161e-05 / 0.003859622145256892	0.03771979541922566 / 0.03295200627528048
785	PDGFRB_2	5_150135511_G_A / 5_150129967_A_C	2.9565587793102473e-05 / 0.0011142332419287124	0.007951396082365123 / 0.010884978116376998
786	ASPH_2	8_61578734_T_G / 8_61638365_TA_T	3.0349566769525607e-06 / 0.014784455717628972	0.00027481062695969863 / 0.0033421074285719613
787	MRPS25_2	3_15065217_A_C / 3_15065038_A_C	3.231333497421803e-05 / 0.03913000849637771	0.0017607662142123156 / 0.008302391831822605
788	CNIH4_2	1_224356827_A_G / 1_224379302_G_A	3.345540294148141e-05 / 1.3298114540105321e-05	8.270232693194595e-06 / 0.004957072960670954
789	STAT5B_2	17_42212246_T_A / 17_42218217_T_TG	3.457612678303974e-05 / 0.009108698459398929	0.049805612849012526 / 0.041598649064757576
790	NRF1_5	7_129690176_C_G / 7_129709261_G_A / 7_129710330_A_C / 7_129711604_C_G / 7_129717099_T_G	3.514964941916984e-05 / 0.0012574856804500286 / 0.0029569614211133396 / 0.0009106050710647207 / 0.0008333980926761285	0.0008588680251565 / 0.0020358531276104324 / 0.001863531871592876 / 0.00048643171799331433 / 0.006420212881434713
791	C21orf58_2	21_46302477_A_G / 21_46322980_A_AG	3.600317129022087e-06 / 0.000178616399448272	0.028316032350682373 / 0.0464048927112107
792	EBF1_2	5_159099526_TA_T / 5_159099526_T_TA	3.7020844162640586e-06 / 0.0061991425888554795	6.309766911659592e-06 / 0.009920112112628023
793	PCNT_10	21_46438359_T_C / 21_46440304_C_T / 21_46442711_A_G / 21_46444647_CTTT_C / 21_46444900_C_T / 21_46444910_G_C / 21_46355631_G_C / 21_46425893_A_C / 21_46444675_T_G / 21_64G446T	3.8924131898677556e-05 / 0.00010294155569212726 / 0.00442543345514155 / 0.0007255960816556072 / 2.666879695038341e-05 / 2.666879695038341e-05 / 0.045239341586552524 / 0.0052653795831940926 / 0.011583428163992472 / 0.0012373038631552345	0.0007850146452497258 / 0.0011784720417395535 / 0.0010237263069919882 / 0.01824823490083048 / 0.00036147873774628185 / 0.00036147873774628185 / 0.0004512031541319047 / 0.01998375792506145 / 0.009046665740785187 / 0.01284951528238673
794	RFT1_3	3_53104238_T_C / 3_53120116_ATTAACTGCAC_A / 3_53120127_T_G	4.1039519054300644e-05 / 0.010916191776172972 / 0.0009241739865608092	0.019143884189355254 / 0.0012736601162827682 / 0.0003755806923286365
795	NGLY1_4	3_25733865_A_C / 3_25736073_G_T / 3_25764388_T_C / 3_25732334_A_C	4.193690016854428e-05 / 1.0629890346566115e-06 / 0.00018111373229034528 / 0.000337635257557846	0.004048589804059987 / 0.0001003348545752524 / 0.008193558074218642 / 0.0008517116761761035
796	SHPRH_2	6_145955343_T_G / 6_145922945_GT_G	4.197525341776357e-06 / 0.02497921302813516	0.0019437040989644704 / 0.0032085441168495693
797	PSAP_4	10_71817510_G_A / 10_71820222_G_A / 10_71823763_G_C / 10_71825769_A_G	4.253559292570684e-05 / 1.4584188008395623e-05 / 0.0007450217858733059 / 7.15024619363838e-07	0.005989723973244358 / 0.004815444492138627 / 0.005093191498317171 / 0.001137729147313085
798	EPG5_4	18_45907942_A_G / 18_45860332_T_G / 18_45967161_TG_T / 18_45949582_G_A	4.41056482155363e-05 / 0.0325761410753079 / 5.0265150457437094e-08 / 0.0009686733993730644	0.00018099150138285703 / 5.454441871402812e-06 / 0.0031405068156816515 / 0.04928013785599337
799	GRB7_2	17_39746744_A_C / 17_39737973_T_C	4.445333626793725e-06 / 3.7814817628535414e-05	0.015646545098240962 / 0.0275943135807812
800	TBC1D5_5	3_17233681_G_C / 3_17238034_T_C / 3_17258641_A_C / 3_17428395_ATG_A / 3_17238102_T_G	4.500069192335354e-07 / 5.287266410953234e-06 / 1.0934340959097885e-06 / 0.00038136339583758066 / 0.0015374412890621536	0.034850654424783314 / 0.048246561657752436 / 0.034850654424783314 / 9.180133184684152e-05 / 0.00428366923460265
801	TTLL3_5	3_9825941_C_T / 3_9826893_A_G / 3_9829346_T_G / 3_9832986_G_A / 3_9835303_G_A	4.506908857236149e-08 / 9.62440960091469e-07 / 6.721794266994746e-08 / 3.966565971028462e-07 / 0.047234941799100816	0.004512931116648239 / 0.009182452462015591 / 0.0016666988915567758 / 0.005845443747610279 / 0.00549007437147901
802	HAUS1_4	18_46118343_C_T / 18_46123257_C_G / 18_46122767_C_T / 18_46118217_A_T	4.791384820535998e-09 / 9.485176947904584e-06 / 0.0008672645013724843 / 0.00028116915718734436	0.0017369506644946814 / 0.009435638863427392 / 0.00147832294217736 / 0.0031860563996751264
803	FGD4_3	12_32640343_A_C / 12_32640545_A_C / 12_32582270_A_C	4.811506604588182e-07 / 0.027930843946287982 / 0.032681639982183666	0.0008756223675282764 / 0.0092856233481216 / 0.0015384650399147507
804	PPDPF_2	20_63522320_T_G / 20_63521771_A_C	5.287951236043515e-05 / 0.00689972604034751	0.043695255169413805 / 0.0005655672033991309
805	ITGA2_2	5_53091493_C_T / 5_53042183_A_C	5.4531358390517686e-05 / 0.03919199794742103	0.043791975990725485 / 0.0012604443318972665
806	SLC44A3_5	1_94839884_A_G / 1_94865029_A_C / 1_94857210_T_G / 1_94857357_C_G / 1_94892383_G_T	5.602338522082008e-05 / 0.046411065532556 / 0.007150508797521116 / 0.017457449518246654 / 0.009632517735858792	0.038972716080465035 / 0.008550555716824466 / 0.016460335501241437 / 0.008036938687219244 / 0.029740691948763408
807	USP4_5	3_49284594_T_A / 3_49305742_G_A / 3_49324936_C_T / 3_49335612_A_G / 3_49302213_T_A	5.782019897669962e-06 / 7.19205729889027e-06 / 1.709904241092868e-05 / 7.19205729889027e-06 / 5.51522445922424e-05	0.0014702427553570136 / 0.0018428609815186782 / 0.0024991863535684788 / 0.0018428609815186782 / 0.0003850173954240535
808	CCDC12_4	3_46922012_T_C / 3_46923707_C_G / 3_46941247_T_C / 3_46923591_T_G	5.914685515407129e-06 / 0.0018228664081414493 / 0.005309522612383735 / 0.004983454832882268	0.030142804350997518 / 0.03284103078371856 / 0.032410896819240385 / 0.04034475330385405
809	TRIOBP_4	22_37723206_G_A / 22_37734378_A_C / 22_37765828_T_TG / 22_37750578_C_T	5.971478816203375e-05 / 0.00027985715683595134 / 0.00029261375791339014 / 0.0030808446512811693	0.0051569691660451255 / 0.009407307485487609 / 0.022947122514129482 / 0.01009941891139795
810	RAF1_2	3_12603508_C_T / 3_12606048_T_TG	6.128646872671697e-07 / 0.0039523881023646075	0.0022616226810353037 / 8.653379217936721e-05
811	FMNL1_5	17_45241411_G_C / 17_45241412_C_G / 17_45243751_T_G / 17_45232440_T_G / 17_45244864_G_C	6.171874985510183e-05 / 0.00015929956646855425 / 0.003538404752618725 / 0.004784366369409091 / 3.9901595948387376e-05	0.0020906187745857413 / 0.0076474907511281205 / 0.013884774496511404 / 0.006430399709476225 / 0.0024365462048673877
812	RIPK4_2	21_41746606_T_G / 21_41746170_T_C	6.423837221659731e-05 / 0.00010177497615683857	0.014247426375762309 / 0.03297049438127817
813	AGPAT5_2	8_6724964_A_C / 8_6757085_A_G	6.429038885162565e-07 / 0.00364477408851887	1.266950151869815e-06 / 0.001321765776974001
814	USP48_3	1_21703696_T_C / 1_21706077_T_G / 1_21706735_G_A	6.450311033122228e-05 / 0.00028299304853152363 / 0.00012669514216415802	0.007845997236531468 / 0.01309954874203597 / 0.004449445235290158
815	AP1M1_8	19_16206608_T_TG / 19_16226612_T_C / 19_16227721_G_A / 19_16228258_G_A / 19_16228904_C_T / 19_16233717_C_G / 19_16234288_T_C / 19_16228794_T_G	6.528413032668653e-05 / 0.0064557081074910596 / 0.0024361725049911105 / 0.01837918810861549 / 0.025114292331133558 / 6.165054004198194e-05 / 0.002051667150159714 / 0.0008804072022582094	0.0008868669473225051 / 0.01491435109247843 / 0.00492438514382162 / 0.0030213758122107693 / 0.00454785100704076 / 6.396974124132157e-05 / 0.007302514064743812 / 0.008904488847639608
816	DAZAP1_2	19_1432575_T_C / 19_1432578_A_C	6.972933286419396e-09 / 0.00010616832462214354	0.008783799588482919 / 0.004625103934387489
817	PACSIN3_2	11_47180569_G_A / 11_47182508_A_C	7.134768403726839e-05 / 0.04020981298829434	0.021285924311691296 / 0.004000006496631303
818	R3HCC1_4	8_23288582_A_G / 8_23291465_G_T / 8_23293365_T_G / 8_23290051_G_A	7.2991599811489e-05 / 5.994421359171259e-05 / 0.012526023152146196 / 0.010041573920909331	0.02377854438814787 / 0.02377854438814787 / 9.39093538138813e-05 / 0.0033896878620269183
819	SERPINB5_10	18_63486810_T_C / 18_63487155_C_T / 18_63489373_G_C / 18_63493054_T_C / 18_63493152_T_C / 18_63503267_T_C / 18_63503488_T_C / 18_63503549_A_G / 18_63503234_G_A / 18_63504	7.512909343200293e-07 / 1.61367941078967e-12 / 0.0017661748524282887 / 0.00358191163139034 / 1.15283914089761e-08 / 3.707481964958598e-05 / 3.699707858963291e-05 / 1.4974781606492456e-10 / 8.547425345240158e-05 / 0.001617719369677095	0.002310192116365421 / 0.0001900079796436893 / 0.0024982561142762962 / 0.004570527834506507 / 2.6119929305428517e-05 / 0.004811319593060203 / 0.00038813827261946135 / 0.0001894559075360232 / 0.008723212833525323 / 0.023248521588281557
820	U2AF1_2	21_43107500_A_C / 21_43107485_A_C	7.700487442691808e-05 / 0.0006563940756543221	3.5456060624197415e-05 / 0.0031649133811599275
821	LLGL2_4	17_75569181_T_A / 17_75558442_C_G / 17_75573695_C_CCT / 17_75575074_T_C	7.971949158890872e-06 / 3.785506483286314e-07 / 0.0064833437780985005 / 0.00395910816955325	0.018355040177942674 / 0.0004418073280201704 / 0.047670437975331784 / 0.004283559000108913
822	PPFIA1_4	11_70365468_A_G / 11_70375250_G_T / 11_70337631_C_G / 11_70331778_TCAAAAA_T	8.1777600824213e-05 / 2.2154751602898654e-10 / 0.007683460638024795 / 2.733195536548977e-07	0.01601938240153477 / 1.0104020665663723e-05 / 0.008528354106314544 / 0.002219921170959074
823	STAG3_2	7_100197862_A_C / 7_100182660_G_A	8.238419261021031e-05 / 0.008737491145039442	0.0017528283507844654 / 0.035261037489752685
824	MYO5B_13	18_49837561_G_C / 18_49875910_A_C / 18_49937217_A_G / 18_49954290_G_A / 18_49847096_G_A / 18_49849562_C_G / 18_49849733_C_G / 18_49880543_A_G / 18_49880568_T_C / 18_49_49_4949	8.380774951798238e-06 / 0.006905476699523033 / 2.4263131433880795e-10 / 1.7494996128043332e-06 / 5.5387782704635815e-05 / 3.8985071268389133e-07 / 7.81858565470932e-07 / 1.54439656564615e-07 / 2.371423829111085e-08 / 8.182928745989 07 / 2.0981325041460703e-11 / 3.691444258026264e-11	0.03791686668587351 / 0.011592306302894794 / 0.0007689742137758647 / 0.011825548378506088 / 0.024802045476053625 / 0.0005688441791387698 / 0.0007265409595720793 / 0.010189243521059816 / 0.00680321425888459 / 7.83580041933832e-07 / 0.004868666362089778 / 9.442141848
825	ZNF441_2	19_11767280_T_G / 19_11778532_C_T	8.6437303626739e-08 / 3.655373741478951e-07	0.00119501780413069 / 0.007941778018462287
826	FAM83H_3	8_143728128_T_G / 8_143725596_G_C / 8_143730455_T_G	9.215742981089235e-05 / 0.005987749784597274 / 0.0009621524329080232	0.005904909381665708 / 0.003207570177222234 / 0.011128551580065676
827	KCNAB2_4	1_6085319_C_T / 1_6095272_T_C / 1_6085347_G_A / 1_6094357_C_T	9.311243022811629e-05 / 0.0002214464879819671 / 0.007488052354416149 / 0.0004024482530986694	0.04271710391545418 / 0.04289813943359165 / 0.010697792728178102 / 0.030197643178852058
828	MMP15_4	16_58038249_C_T / 16_58042518_A_G / 16_58045261_G_A / 16_58037634_A_C	9.375120301838935e-05 / 1.005487978512005e-05 / 0.00013842386491697844 / 0.035127559966572304	0.006545735139458929 / 0.008269298799745639 / 0.016496855574598585 / 3.732680793190984e-05
829	PKNOX1_3	21_43028653_G_C / 21_43028665_G_A / 21_43029807_G_A	9.45086875135022e-05 / 9.45086875135022e-05 / 0.0028391505331848486	0.02993846952653303 / 0.02993846952653303 / 0.04630035756513505
830	CNOT6L_3	4_77720488_T_G / 4_77720486_A_G / 4_77726534_A_C	9.499774295611595e-07 / 0.0011515987198065605 / 1.5337206523072135e-05	0.00045440611666765506 / 0.003812687853894012 / 0.002323583718729919
831	C1orf109_4	1_37683521_C_T / 1_37689469_G_GGT / 1_37689593_G_C / 1_37684175_A_G	9.499906971175951e-07 / 3.357943291134777e-07 / 2.4786643546299445e-07 / 0.03129818295251388	0.0019238150218027989 / 0.005985910424044681 / 0.004025869106193675 / 0.0047335795687796075
832	MAP7_2	6_136361034_G_A / 6_136411526_G_A	9.631600220201912e-05 / 0.00020915694169969668	0.004233710215813943 / 0.03701019146859175

Table 18 shows the biomarkers associated with the ERK_MAPK drug and the degree of reactivity (P-value) of the drug by the table.

In [Table 18], FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the value of the correlation (P-vlaue) that the marker has on the reactivity of the drug. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 40, correlation values (P-vlaue) values of ERK_MAPK drugs of major biomarkers among the biomarkers described in [Table 18] are graphically displayed.

Reactivity biomarker for ERK_MAPK drug and verification result of reactivity with drug

No.	FRH	Variants	Var_Drug (pval)	Var_Exp (Pval)
One	INHBE_1	12_57456335_T_G	5.77E-14	0.023018015
2	SMAP1_1	6_70773272_G_A	1.18E-08	0.029985176
3	SPRY4_1	5_142319698_T_G	6.07E-08	0.000420223
4	THEM4_1	1_151909409_A_C	8.56E-08	0.035981352
5	SERPINB1_1	6_2837820_C_G	1.44E-07	0.008676416
6	EIF2B3_1	1_44926782_G_C	7.36E-06	0.00572911
7	DUSP6_1	12_89350540_G_A	8.18E-06	0.001102792
8	TOLLIP_1	11_1295591_A_C	1.13E-05	0.041990571
9	CDC5L_1	6_44387945_G_A	0.000100417	0.000850114
10	PAPD7_1	5_6746131_C_G	0.000186035	0.046879537
11	ABHD2_1	15_89199849_C_A	0.000373834	0.002565266
12	PLEKHM1_1	17_45436185_C_G	0.002692591	0.035787973
13	SMC6_1	2_17731999_A_C	0.003115924	0.045907596
14	RNF38_1	9_36400965_C_G	0.004214532	0.007012003
15	METTL16_1	17_2415256_G_C	0.007239539	0.043637945
16	PARP2_5	14_20351190_T_A / 14_20354336_G_T / 14_20344985_T_C / 14_20354983_A_C / 14_20354994_T_C	0.0003461397642250317 / 0.008144629651779057 / 1.6511185678613746e-06 / 9.423861936900617e-06 / 4.248961897732616e-05	0.0026213592391782425 / 0.0343587058197046 / 0.0388723494826529 / 0.009448771221863612 / 0.035110640891692815
17	CRYL1_6	13_20439533_A_G / 13_20439514_CA_C / 13_20404113_C_G / 13_20404176_A_C / 13_20489466_A_C / 13_20512438_C_G	0.0007457569282103447 / 0.04490288969730257 / 5.4112288097843236e-05 / 0.0004125161353078136 / 7.340308839823958e-10 / 0.0008144017559447111	0.02254568941445808 / 0.006925654927699 / 0.014412490268573512 / 0.0358490969666835 / 0.0036810252474824734 / 0.0005690585314639865
18	MBD2_2	18_54222304_G_C / 18_54224621_A_C	0.0009174927734817775 / 0.003370522943374522	0.041746449937120685 / 0.0024467066581282037
19	NUCKS1_3	1_205727543_G_A / 1_205720599_G_C / 1_205719615_A_C	0.0019226380117114328 / 5.15182042228384e-07 / 5.169743185885884e-06	0.007966391204853542 / 0.0020116543690140926 / 1.829062095579077e-05
20	TMEM8A_4	16_377516_T_C / 16_374277_G_A / 16_377010_C_T / 16_375326_T_G	0.0022458300017618115 / 0.0004991219763661549 / 0.008152821570691773 / 0.00033905970470333573	0.02280191742379471 / 0.008448241096869875 / 0.02464199505583077 / 0.03164430214292932
21	MCM8_5	20_5950428_T_C / 20_5954739_T_C / 20_5967525_G_A / 20_5963301_T_G / 20_5983067_T_G	0.002650766144390827 / 0.0020883309843753076 / 7.538671246466503e-12 / 0.0005138671174250025 / 0.00032159758644408336	0.02450503355623649 / 0.0030061115573713558 / 0.02006455848870967 / 0.0209284066776318 / 0.012878505995892143
22	COPS3_3	17_17280719_G_T / 17_17249049_GAA_G / 17_17280660_A_C	0.0027601645216709264 / 0.0055818454987667495 / 0.009754104106729505	0.019538058668087298 / 0.04875712280071096 / 0.02319033941785423
23	NEDD1_2	12_96937308_A_C / 12_96936634_A_G	0.004287874507177774 / 0.0016187072229015974	0.019399114812349873 / 0.02229964139566365
24	HDAC6_3	X_48803171_T_G / X_48817284_T_G / X_48817251_CAA_C	0.007173863496387051 / 0.0004972749557463768 / 0.0027277691674834114	0.008701773238861378 / 3.6233113107314475e-06 / 0.00929153924222002
25	MRPL39_6	21_25592759_G_A / 21_25601549_G_T / 21_25603910_C_T / 21_25603925_C_T / 21_25604009_G_A / 21_25599683_T_C	0.007753577611892022 / 0.0015571108862256187 / 0.005054758659783033 / 0.00740873550689033 / 0.005591788896050463 / 0.03750113388472616	0.033844596383331746 / 0.005711821633941189 / 0.043198910460816656 / 0.020407458243495952 / 0.026357543170222462 / 0.002961561939886723
26	ZBTB8OS_2	1_32621836_G_A / 1_32634036_A_G	0.010623328091650126 / 0.005807902867508034	0.00035085154745507385 / 0.001609648081432905
27	SNRPC_3	6_34767901_T_C / 6_34767875_CT_C / 6_34767875_C_CT	0.016258858934554518 / 0.0255807459946655 / 0.008409734593854818	0.0021977163744789038 / 0.005833052025345314 / 0.047890724740450176
28	SH3TC2_5	5_149010200_G_A / 5_149026823_T_C / 5_149040673_A_C / 5_149040676_A_C / 5_149004975_C_T	0.036452606469764885 / 7.993368579087101e-05 / 1.313354358475822e-12 / 1.6742742304793365e-07 / 3.0188094863269486e-08	0.005163368200425915 / 0.02459748424962984 / 0.04603790254373362 / 0.03254802106345967 / 0.01898788013634638
29	NUP188_7	9_128970680_G_T / 9_128981422_CT_C / 9_128999694_A_C / 9_128993243_C_G / 9_129003287_A_C / 9_128952722_CAAAA_C / 9_128981422_CTT_C	0.03889727834709586 / 5.679744903985549e-07 / 0.00015792708806478532 / 0.00011477857081826123 / 0.006528287639189813 / 1.3483326927899365e-05 / 0.001011406252669107	0.006235319995753044 / 0.0026090470755132837 / 0.04562376131737803 / 0.034372383646284414 / 0.006351306341421021 / 0.030396670064505107 / 0.0486576378436576
30	PDCD5_2	19_32581360_T_C / 19_32581212_C_G	1.0613555124907784e-06 / 0.01707686442489131	1.930613826710712e-05 / 0.00963168433129465
31	PCDH1_5	5_141865023_A_C / 5_141864261_A_C / 5_141864335_T_G / 5_141854096_T_G / 5_141864895_A_C	1.146087693284126e-13 / 2.954523514000492e-06 / 1.2399540998886776e-05 / 6.010776449757326e-05 / 1.3125365237964413e-06	0.00022379266342278662 / 0.0017861354200376558 / 0.02539846277902666 / 0.023845011173266668 / 0.014684779508972238
32	ARL6IP6_3	2_152718606_T_G / 2_152718941_T_G / 2_152718947_T_G	2.1444201135699293e-06 / 3.4179740940841686e-10 / 5.150737082224498e-05	1.916382486428584e-05 / 0.0014347496711839814 / 0.0018772601891545288
33	TPP1_3	11_6616021_T_G / 11_6619456_A_C / 11_6616207_T_G	3.898164047661344e-05 / 6.206193500590457e-06 / 7.13357999675385e-06	0.03721832122361987 / 0.0021180587349231865 / 0.022734527785541702
34	SLC35B2_2	6_44253096_A_C / 6_44255584_T_G	4.1264755521968e-08 / 2.206940612751773e-06	0.045514675788588387 / 0.0354190738183241
35	ETV5_6	3_186057145_T_G / 3_186057158_T_G / 3_186105591_G_A / 3_186064432_A_G / 3_186057367_T_G / 3_186057421_A_C	4.28224233645744e-14 / 2.8538105380699127e-12 / 3.537860306738235e-07 / 3.53456731728789e-05 / 8.933112160257351e-07 / 2.0618345030808515e-05	0.000899440048018852 / 5.426858809490545e-05 / 0.008678217049363252 / 0.012387170842740151 / 0.01078700094209001 / 0.04370939373064901
36	DUSP4_2	8_29340229_A_C / 8_29337473_A_C	4.4035389796360024e-07 / 0.0013351841168008725	0.01853773742959819 / 0.013684370845169195
37	ST3GAL4_3	11_126408340_T_G / 11_126406566_A_C / 11_126424657_A_G	4.582342844339244e-12 / 1.1939071093750443e-06 / 6.212889562458534e-09	7.802484819683297e-05 / 0.006286854884921811 / 0.03738872157996522
38	SKP2_3	5_36183922_T_C / 5_36168236_A_G / 5_36168246_T_G	4.974059042110084e-09 / 2.3219549423702208e-12 / 1.6076332463417848e-08	0.008092624659189506 / 0.01597032245832584 / 0.022784487945753537
39	GPBP1_3	5_57230956_G_A / 5_57231420_T_C / 5_57251232_G_A	4.99115882517327e-06 / 1.8819931578981247e-06 / 2.491196233571318e-05	0.038048986044057084 / 0.04556667822911722 / 0.018325268985280727
40	CMTM7_2	3_32441841_T_G / 3_32454197_C_G	5.20316947282785e-11 / 1.865488768400554e-06	0.022587609002975642 / 0.027278626571090647
41	LRP5_2	11_68429633_T_G / 11_68448944_A_C	8.179359573414423e-10 / 2.733681134387847e-06	0.01579807768279053 / 0.024681714140317668
42	ETV4_2	17_43544973_A_C / 17_43533230_T_G	8.216801793356959e-07 / 9.218453009083366e-06	0.025227174262734704 / 0.0007956602344066278

Table 19 shows the biomarkers associated with IGFR drugs and the degree of reactivity (P-value) of the drugs.

In Table 19, FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the value of the correlation (P-vlaue) that the marker has on the reactivity of the drug. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 41, correlation values (P-vlaue) values of IGFR drugs of major biomarkers among the biomarkers described in [Table 19] are displayed in a graph.

Reactivity biomarker for IGFR drug and verification result of reactivity with drug

No.	FRH	Variants	Var_Drug (pval)	Var_Exp (Pval)
One	SEPT6_1	X_119618658_T_G	1.08E-09	0.00240717
2	EPHA2_1	1_16148437_A_C	2.39E-08	0.003022958
3	VRK1_1	14_96853031_T_G	3.01E-06	0.034233405
4	ACTR3_1	2_113934245_G_T	4.92E-06	0.01245207
5	FOS_1	14_75280999_A_C	6.24E-06	0.001488063
6	FCHO2_1	5_73082876_ATT_A	1.08E-05	0.029256929
7	RAC1_1	7_6401802_T_G	2.22E-05	0.003141263
8	CXCR5_1	11_118886492_C_G	6.30E-05	0.044645013
9	KCNQ5_1	6_72622312_C_G	8.39E-05	0.005821769
10	ACSS2_1	20_34920910_T_G	8.92E-05	0.038456731
11	CRLF3_1	17_30792416_T_G	0.000107788	0.014789711
12	TSEN34_1	19_54192354_T_G	0.000113175	0.001848481
13	GTF2IRD1_1	7_74512993_A_G	0.000122837	0.006481631
14	CECR1_1	22_17188516_G_C	0.000127223	0.003052868
15	MAP4K1_1	19_38617327_T_G	0.000134054	0.013203631
16	PAPSS2_1	10_87727355_T_G	0.000165034	0.012652487
17	LAMC1_1	1_183131172_CAA_C	0.000221332	0.002417084
18	TBX21_1	17_47742656_A_C	0.000232988	0.004538883
19	PNRC2_1	1_23961703_G_C	0.000287734	0.015853081
20	HSPG2_1	1_21885485_A_C	0.00029294	0.028105373
21	CD72_1	9_35610848_A_C	0.000296281	0.049937736
22	KLF3_1	4_38689006_A_C	0.000348148	0.015121455
23	ZNRF3_1	22_29048501_A_C	0.000348188	0.024970519
24	ASAP2_1	2_9399979_T_G	0.000416146	0.021780475
25	CCDC69_1	5_151185396_T_C	0.000422551	0.005439839
26	EPS15_1	1_51472751_T_G	0.000562256	0.00454227
27	CBR1_1	21_36071267_G_C	0.000703843	0.005777456
28	CST3_1	20_23634133_A_C	0.000813367	0.047435887
29	IGF1R_1	15_98934682_T_G	0.00081535	0.004668174
30	MEI1_1	22_41699656_A_C	0.000847426	0.019192604
31	PTPN6_1	12_6946697_T_C	0.000924277	0.002400753
32	PMEPA1_1	20_57700062_A_G	0.000939285	0.036764657
33	WASL_1	7_123692324_GA_G	0.001014849	0.000396379
34	ARHGAP15_1	2_143228433_T_C	0.001096444	0.039221572
35	CLDN12_1	7_90413108_T_G	0.00113931	0.004520847
36	UACA_1	15_70669470_GA_G	0.001211403	0.03571568
37	TRIM2_1	4_153276097_A_G	0.001260338	0.011894098
38	RCC2_1	1_17413487_C_A	0.001306044	0.02349276
39	CD48_1	1_160711863_GA_G	0.001708644	0.04718285
40	GLCE_1	15_69261053_A_G	0.001722968	0.004293961
41	C21orf91_1	21_17793434_T_G	0.001758128	0.044828498
42	SIGLEC10_1	19_51417063_T_G	0.00177184	0.045299996
43	NCKAP1_1	2_182967372_CA_C	0.001831659	0.004822611
44	CD86_1	3_122103557_A_C	0.001895858	0.046671667
45	ERRFI1_1	1_8013331_A_G	0.001920351	0.000188249
46	PTPRC_1	1_198703381_A_C	0.001955402	0.027037687
47	CTDSPL_1	3_37957127_T_G	0.002306486	0.04933152
48	TAF4B_1	18_26286027_C_A	0.00252716	0.005234164
49	CDC42BPB_1	14_102939620_T_G	0.002756257	4.78E-05
50	CTBP2_1	10_125026073_A_G	0.002878802	0.03391949
51	RASAL3_1	19_15458567_G_C	0.003342618	0.038134018
52	HLA-DOB_1	6_32813293_A_C	0.003408106	0.048853006
53	WAS_1	X_48691219_A_C	0.00381355	0.02612273
54	HBS1L_1	6_134965300_CA_C	0.004012929	0.010966837
55	FCRL5_1	1_157518564_T_C	0.004367637	0.023539142
56	UHRF2_1	9_6482002_G_T	0.004387102	0.007025127
57	SPR_1	2_72891611_A_C	0.005381455	0.000101783
58	DHX32_1	10_125867071_T_C	0.006025442	0.015306739
59	DAG1_1	3_49531399_T_G	0.006122816	0.000829773
60	RAVER2_1	1_64768580_T_G	0.007604338	0.049067483
61	KIAA0922_1	4_153635457_C_T	0.007681106	0.042172485
62	ITGAV_1	2_186637080_T_G	0.0079744	0.00113911
63	MSL3_1	X_11772199_A_C	0.00797531	0.040182738
64	LAPTM5_1	1_30733959_T_C	0.008095451	0.005337526
65	TPBG_1	6_82364929_T_C	0.009219323	0.003828919
66	CD52_1	1_26320120_TAA_T	0.009857578	0.041028395
67	APOBEC3G_1	22_39086265_G_T	0.009915615	0.042244805
68	ZNF107_1	7_64708051_G_A	0.010400777	0.013846694
69	PALLD_1	4_168691310_GT_G	0.011706523	0.009714355
70	WTAP_1	6_159753424_T_G	0.01384856	0.00215073
71	HCLS1_1	3_121634273_T_G	0.019280657	2.45E-06
72	AVPI1_1	10_97677649_A_G	0.021081758	0.001581419
73	FAM129B_1	9_127578987_C_T	0.021421759	0.016089528
74	SH3RF1_1	4_169096709_G_A	0.024084182	0.008799276
75	DR1_1	1_93361899_T_A	0.025156433	4.48E-05
76	CTTNBP2NL_1	1_112457049_C_A	0.028077079	0.00620874
77	PPP3CC_1	8_22539268_TC_T	0.032546359	0.004572653
78	WIPF1_1	2_174585550_T_G	0.037854213	0.000483959
79	RNGTT_1	6_88769645_C_T	0.04013553	0.002545266
80	CUEDC1_1	17_57873465_G_A	0.046175827	0.009658282
81	TMEM106A_2	17_43216747_A_C / 17_43216763_T_C	0.00010599595448116978 / 0.0011257303404920308	0.0005249300563644175 / 0.0005036765332449491
82	ARHGAP9_2	12_57474996_G_A / 12_57474460_G_A	0.00010627135291362362 / 0.0006872861852919692	0.036897912823510064 / 0.04135748735535435
83	ARHGAP25_3	2_68775067_A_G / 2_68818005_T_G / 2_68818023_T_G	0.00011953760418312583 / 1.4150706205617486e-06 / 0.0059084060389890105	0.04538887525617117 / 0.0040433016624282225 / 0.00032630206809361283
84	LMNA_2	1_156134461_T_G / 1_156139242_AT_A	0.00013744315797654898 / 0.021258069595818274	0.029742625031540286 / 0.04237931129547261
85	DAGLA_2	11_61734985_A_C / 11_61728297_A_C	0.00016688573126791192 / 8.09952511657234e-05	0.004132304336839055 / 0.025660366426589504
86	NR2F6_2	19_17240636_T_G / 19_17232479_A_C	0.0002005112664246795 / 0.004658617789678825	0.0007905076911971658 / 0.04560309985715085
87	PLEKHA1_2	10_122406608_C_A / 10_122426897_T_G	0.0002168843436880945 / 0.005333013480801039	0.013835632948640248 / 0.02718721223708819
88	APP_2	21_25881669_T_G / 21_25881706_A_T	0.00025836883792981226 / 0.012490170798802495	0.0009005203285702301 / 0.007363278374314075
89	ATP1B1_2	1_169127312_A_G / 1_169131404_A_C	0.0002769045008439269 / 0.0004647954716516378	0.009381431280957959 / 0.04764456683437238
90	IL10RA_2	11_117999603_A_C / 11_117999569_T_G	0.0003635149788055047 / 0.002791509228208489	0.033136103226175016 / 0.042909053419655285
91	ERICH1_7	8_658279_A_G / 8_659132_C_G / 8_659777_T_G / 8_666991_A_G / 8_673593_G_A / 8_659879_A_C / 8_664843_G_C	0.00036987702944603015 / 5.389836081615414e-05 / 0.042347501906470714 / 0.03423827293146818 / 0.002457155038695027 / 0.005217531740497581 / 0.03193881349739397	0.004174871941240723 / 0.0054140514901705895 / 0.007294372779032101 / 0.0012649483439199085 / 0.01865482112843118 / 0.0461414202945825 / 0.005281332497371782
92	ITGB5_4	3_124769064_T_G / 3_124809087_T_G / 3_124817591_T_G / 3_124859372_A_C	0.0004279586059829587 / 0.0005503781084358106 / 2.8998064871450438e-05 / 0.007293322508081707	0.0006588536356118503 / 5.4585187494895796e-05 / 0.004666117329251896 / 6.144253538463827e-06
93	RFTN1_4	3_16357670_G_A / 3_16369972_C_G / 3_16433938_A_G / 3_16316966_A_C	0.0005124144917873522 / 0.0007740692582134723 / 0.02739900235302105 / 1.3310696006188425e-05	0.014764917085914387 / 4.009218111239421e-08 / 9.30606513108498e-07 / 0.008243705342181723
94	RBFOX2_4	22_35759903_A_G / 22_35746471_A_C / 22_35761128_GA_G / 22_35745982_A_C	0.0005772251529531363 / 0.0026032665751075587 / 0.0005990432899641425 / 0.00370365047461572	0.0021501446732444386 / 0.003606660377686972 / 0.04845122900481105 / 0.009865449869643949
95	VSIG10_3	12_118095590_T_G / 12_118073908_T_G / 12_118095640_G_C	0.0006180518934147943 / 0.000288504312752602 / 0.003668316042902092	0.013058144491121623 / 0.0019761216603789984 / 0.03443934455659579
96	PLEKHG3_2	14_64741663_T_G / 14_64743474_T_G	0.0007814263254356411 / 0.001157048611523175	5.022222887595109e-05 / 0.0004341351157000161
97	ATP11A_7	13_112832759_A_G / 13_112871823_T_C / 13_112860417_A_C / 13_112810736_A_C / 13_112856140_A_C / 13_112832768_A_C / 13_112860332_A_C	0.0007951918344761818 / 0.0005482830943215422 / 0.0008173410245384687 / 0.00028609539850556404 / 0.0005652380914145368 / 0.01755140978606275 / 0.0026211055327575693	0.03593739412008719 / 0.030074291108272512 / 0.013638179892540932 / 0.02325523862538697 / 0.008605914805152383 / 0.0022773790348338983 / 0.006067631423556552
98	RUNX3_2	1_24907301_T_G / 1_24907326_T_G	0.0008468237773895464 / 0.006925491973632575	0.0479402881785652 / 0.03367486268556343
99	CTTN_3	11_70419876_A_C / 11_70419880_T_C / 11_70407283_C_T	0.000966697322875658 / 3.5345921815367516e-05 / 0.005641133258474765	0.00030309409522359497 / 0.003131141961303907 / 0.005941149857145408
100	CCDC28A_2	6_138785343_A_C / 6_138792859_T_C	0.0013622718680866052 / 0.005185054082793079	0.011499421256994664 / 0.046299906365056015
101	CD63_3	12_55725557_A_C / 12_55725568_A_C / 12_55727027_A_C	0.0015370519252913715 / 4.143328592583745e-05 / 0.0004442658715243917	0.006833645667760305 / 0.006277176385590093 / 0.0005016030317793939
102	SCARB2_2	4_76179751_A_C / 4_76179754_T_C	0.0016868597515864868 / 0.0015619118205883007	0.009508010711643462 / 0.003674712454161551
103	TJP1_4	15_29737354_A_C / 15_29761137_A_C / 15_29761418_A_C / 15_29718609_T_G	0.001722668303128766 / 0.001802650233952311 / 0.0039948883415691075 / 0.0004981143114140755	0.03635480241931981 / 0.005695684405240236 / 0.0032087876676378537 / 0.035918560945748516
104	CD84_2	1_160549875_A_G / 1_160550877_C_G	0.0018095916002787247 / 0.0007689474612337844	0.011914227680681896 / 0.04088607952168802
105	IKZF1_3	7_50368194_A_C / 7_50382645_A_C / 7_50387420_G_C	0.0018105241430139086 / 0.014707321465940356 / 0.001698752501804824	0.008403541889994377 / 0.009343110426337882 / 0.005840601801883746
106	LCP1_3	13_46143111_T_C / 13_46143326_T_G / 13_46143333_A_T	0.0018838737568387656 / 0.0030138622548272647 / 0.002533014213361492	0.004087453394348643 / 0.0014213406956657436 / 0.005160539969200112
107	FAM177A1_2	14_35081207_T_C / 14_35081218_T_C	0.0021562993680550448 / 0.0011900365723686852	0.020934419309292008 / 0.02682119468565008
108	WDR91_2	7_135211631_T_C / 7_135187272_A_C	0.0024692334154964657 / 0.032950442555311085	5.806021129546451e-05 / 0.006217596359933296
109	KLHL6_3	3_183492078_A_C / 3_183508233_G_T / 3_183508495_A_C	0.0026331756981726236 / 0.022647868110278375 / 7.774725762863598e-05	0.03828309904439229 / 0.005722620392157443 / 0.025101287121564474
110	ZNF543_2	19_57329179_A_G / 19_57328339_A_C	0.002905904571144909 / 0.0017155256244295665	0.0030296713890405878 / 0.0008395371531401164
111	PLEK_6	2_68380987_A_C / 2_68380990_A_C / 2_68386526_T_G / 2_68388306_A_G / 2_68388311_A_G / 2_68395610_G_T	0.0029347945425916644 / 0.002463266314490245 / 0.0008850637706738338 / 9.333617954680645e-06 / 0.0006950651263355477 / 0.0073361864658662125	0.0018651167043750433 / 0.004434568689990568 / 0.0232360676072928 / 0.012112306050675708 / 0.028732570109628937 / 0.04207168924285536
112	KDM4C_2	9_6990364_G_T / 9_7103596_C_T	0.0029959320396048127 / 0.031190087077651845	0.01165227785409256 / 0.0003043755324224803
113	STAG3_6	7_100197862_A_C / 7_100197337_A_T / 7_100197348_T_C / 7_100201126_G_C / 7_100180467_A_G / 7_100202616_A_T	0.003032352954227882 / 0.0003006428065929603 / 0.0015227072304436168 / 7.395320763427399e-05 / 2.7805601294277643e-05 / 0.0008727651283899594	0.0017528283507844654 / 0.0366941229125814 / 0.023320205307304158 / 0.027602097077102532 / 0.04660308396540184 / 0.020109594472644786
114	WDFY4_2	10_48733932_A_G / 10_48709976_C_T	0.00343399726598083 / 0.014958425459696244	0.04160917875360734 / 0.036092320181802036
115	PEX3_2	6_143462894_AT_A / 6_143468044_A_T	0.0038068988591272368 / 0.004816984657632503	0.01772831437707046 / 0.001265609891969809
116	FERMT3_2	11_64207498_T_G / 11_64220073_T_G	0.004734854868796705 / 0.0003860702269228193	6.601869405274685e-06 / 0.034308160983635066
117	ARHGAP5_3	14_32092970_T_C / 14_32154828_T_C / 14_32092963_G_C	0.00497062236861118 / 0.0024371349542205195 / 0.03352695059876293	0.000109609141495362 / 0.0028505632724505807 / 0.007275592799482284
118	NGLY1_3	3_25733762_T_C / 3_25736073_G_T / 3_25732334_A_C	0.0050051985544428655 / 0.00013354579539043645 / 0.00040433124284776166	0.0004571643127465467 / 0.0001003348545752524 / 0.0008517116761761035
119	NCKAP1L_3	12_54532103_A_T / 12_54509948_A_C / 12_54542688_G_C	0.005115130095563281 / 0.006142923665719964 / 0.003395761947631717	0.006178462220094093 / 0.01506335399115959 / 0.04657402586559346
120	DCK_2	4_71023692_C_A / 4_71022615_CTT_C	0.00551147320732032 / 0.003204858946259472	0.03456399228988244 / 0.04731976901534782
121	CNOT10_2	3_32705030_A_G / 3_32717271_G_A	0.005986207049477181 / 0.010027593265925021	0.0007110070373588129 / 0.0032142136890770555
122	ZNF430_2	19_21033730_G_A / 19_21022773_T_G	0.0060011071152059935 / 0.001269711279469131	3.875366882434858e-05 / 0.024171318376603662
123	DIRC2_2	3_122795117_A_C / 3_122856322_A_G	0.006254194164645703 / 0.003207873756680403	0.006533610459085206 / 0.013416690563532
124	DENND1C_2	19_6469618_A_C / 19_6466439_T_G	0.0067186287718049645 / 0.0016600261620732227	0.03949757317188018 / 0.022653353998851232
125	MRPL39_3	21_25592788_C_A / 21_25601549_G_T / 21_25599683_T_C	0.007244177399862964 / 0.02581153853071456 / 0.006446955687932745	0.0040263096113157286 / 0.005711821633941189 / 0.002961561939886723
126	POLH_2	6_43587207_T_G / 6_43587205_A_G	0.007282790737761695 / 0.004119102235979657	0.002197498680435875 / 0.0001905626583652103
127	LTBP3_4	11_65547976_T_G / 11_65547974_A_G / 11_65541348_A_C / 11_65543270_A_C	0.008230993013661442 / 0.002905381602762654 / 3.41563836791927e-05 / 0.000404704876316852	0.0010020580443514707 / 0.013780067605462305 / 0.02423580877660449 / 0.030868539513201374
128	CCND1_2	11_69650913_A_G / 11_69643258_A_C	0.009099246706999426 / 0.0062885656582625715	0.024298615321604846 / 0.0008578909246964013
129	CTNNA1_4	5_138812304_T_G / 5_138933920_C_T / 5_138932696_A_G / 5_138812295_G_A	0.009367597372283164 / 6.3503870330673816e-06 / 0.025253708380473885 / 0.0007665667912501635	0.013339032203366944 / 0.00010488952235634391 / 0.007557173168109447 / 0.014548265287747147
130	WDR7_2	18_56679573_T_G / 18_56781547_G_A	0.00936770621562205 / 0.0029337854053434692	1.7583606026050092e-08 / 0.0071713352600959014
131	RCL1_5	9_4844704_T_C / 9_4844778_A_C / 9_4849647_T_C / 9_4860917_G_GT / 9_4860980_G_A	0.01015934986765833 / 0.008166765063815772 / 0.013723578341305795 / 0.006228375621470136 / 0.0009546809601140933	0.001687161016128972 / 0.0053342789487147045 / 0.004306767506877943 / 1.3652309819438526e-05 / 0.014590769537426704
132	ZCCHC14_5	16_87414470_A_C / 16_87411666_T_C / 16_87412604_T_G / 16_87412609_T_G / 16_87407905_T_G	0.01093006007749231 / 0.004904074942282202 / 0.0043682847900583565 / 0.00032200703750807235 / 0.00016922609654741882	0.007871655864135534 / 0.012673355773035487 / 0.00292819630706063 / 0.0093411624607831 / 0.04674575207321762
133	TOM1L1_3	17_54937096_G_T / 17_54937101_G_T / 17_54947274_A_C	0.011389249245863157 / 0.02378503173158879 / 6.37493870407225e-05	0.0005351253630963304 / 4.7382046214109506e-05 / 0.0003719570020930906
134	SVIL_2	10_29532000_A_C / 10_29486218_G_T	0.014203541816552456 / 3.6685991514458535e-06	0.005199248570547408 / 0.02127330473082788
135	TEAD4_2	12_3019250_C_T / 12_3022032_A_C	0.02289390603064881 / 0.0001066489771189534	0.0016254072731388984 / 0.0001892435681560084
136	ARHGAP30_2	1_161052161_T_G / 1_161069551_T_G	0.026797750313656932 / 0.0002673414213531623	0.0011705834898046734 / 0.030642225735204174
137	FMNL1_3	17_45232440_T_G / 17_45238511_T_G / 17_45238503_C_G	0.02756877460315332 / 0.0011473580213809565 / 0.0021134470829949274	0.006430399709476225 / 1.3130360508344227e-05 / 0.014111760701313713
138	CD151_3	11_836023_C_T / 11_836227_A_G / 11_835877_C_T	0.031310628277621426 / 0.01189492161114428 / 0.0465236859230004	0.004311678571283407 / 0.001633994415617101 / 0.005759250847020773
139	MBD2_2	18_54204938_G_A / 18_54224621_A_C	0.032527518290623295 / 0.02387217907579878	0.007481293790069707 / 0.0024467066581282037
140	ACAP1_2	17_7350305_C_T / 17_7343627_T_G	0.03440244080220003 / 9.989468867792128e-05	0.009955377908509965 / 0.02484432576482206
141	RHPN2_4	19_33002924_G_A / 19_33044231_A_G / 19_33044540_A_C / 19_33011638_C_G	0.03758598191114063 / 6.498164345874758e-05 / 0.0019234652198936038 / 0.0005607094271426628	0.001694407500706198 / 0.0003445437417821702 / 0.0007353894363862997 / 0.0002119158667786005
142	RASSF2_3	20_4797919_T_G / 20_4784304_T_C / 20_4784247_T_G	0.037902749156553485 / 0.011694257494444695 / 0.00032929741865870437	0.007153311060028534 / 0.0020239510039769416 / 0.0013542591543729706
143	MYO1G_4	7_44965836_A_C / 7_44970706_A_C / 7_44964431_G_T / 7_44979051_A_C	0.04191223689634028 / 0.01979144289427551 / 0.00017645318680118606 / 0.041733273291402466	0.007221347246269528 / 0.002699507313002306 / 0.005180419499391653 / 0.0010403929060933288
144	PIK3CD_4	1_9720778_T_G / 1_9720785_A_G / 1_9719895_T_G / 1_9718938_A_G	1.0253516427976307e-05 / 0.0046476512085552105 / 0.00011802831952668278 / 0.006759908616419049	0.0012148539768169404 / 0.0398063487615097 / 0.0044497374818740715 / 0.04703097613769788
145	PTGR1_2	9_111594107_A_G / 9_111578959_GAA_G	1.5065359948490627e-06 / 0.005936401163136037	0.00764869645742515 / 0.03809849817293055
146	SH3D19_3	4_151122202_T_C / 4_151148202_G_T / 4_151175208_T_G	2.2029420860104835e-05 / 0.0016057485146252267 / 0.0049299501495510155	0.00026537095134489047 / 0.004030165987762314 / 0.036616308047703286
147	DTNBP1_2	6_15662698_A_G / 6_15662701_T_G	2.9366152452741533e-06 / 0.0006517798782510246	0.0063060334020981846 / 0.001004314451212422
148	ZNRD1_3	6_30062280_G_A / 6_30062358_G_A / 6_30062412_T_A	3.654974597084793e-05 / 1.1618445697892011e-05 / 0.0003334426304369216	0.006713962039550535 / 0.011500969330972352 / 0.02821821301850212
149	SPATS2L_7	2_200329386_C_A / 2_200412288_CT_C / 2_200329511_A_C / 2_200412421_T_G / 2_200412425_T_G / 2_200477943_T_G / 2_200473083_GAA_G	4.207550681496029e-05 / 0.0004415561732387749 / 2.0249110903712733e-05 / 6.324482115669083e-05 / 0.00042055460201680485 / 1.4403669192542887e-05 / 0.007061797305907755	0.0033487592228469143 / 0.011019446375268936 / 0.02491924164389806 / 0.03547678698863923 / 0.024316311222524558 / 0.016080388811817628 / 0.0009052273948575811
150	ELOVL5_4	6_53295600_A_G / 6_53295602_T_G / 6_53291875_T_C / 6_53291854_T_G	4.333948606334787e-05 / 9.154580881914281e-06 / 0.002303807174924029 / 0.010895023484809672	0.0008036056664569972 / 0.0007993551420952537 / 0.0030362229822457412 / 0.005396507263205953
151	AGER_6	6_32183680_C_G / 6_32183336_A_C / 6_32180626_G_C / 6_32182537_A_C / 6_32182532_A_C / 6_32180983_T_G	4.3474785520824183e-07 / 0.0008401867950240421 / 0.00012577188862559035 / 7.864018103130946e-05 / 0.0001383347487645318 / 0.0006412069737516832	0.026487158302874552 / 0.0008365781303084246 / 0.018710849801424196 / 0.024237923466307005 / 0.005092878554310726 / 0.028565251544064637
152	KLHL18_3	3_47319581_T_G / 3_47344095_C_A / 3_47319585_T_G	5.8893512793953086e-05 / 0.003560559459732024 / 0.0014314792247920815	0.013218876001835087 / 0.0063137500959640856 / 0.0442868915202707
153	RBM6_6	3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50066429_G_T	9.610797412978416e-06 / 0.0004692267600390496 / 0.001169115137001947 / 0.016014825049119413 / 0.00038946159538077817 / 6.545113568163317e-06	0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.0016854676901857401

Table 20 shows the biomarkers associated with the MITOSIS drug and the degree of reactivity (P-value) of the drug by the table.

In Table 20, FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the correlation value (P-vlaue) value of the corresponding marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 42, correlation values (P-vlaue) values of the major biomarkers among the biomarkers described in [Table 20] for MITOSIS drugs are displayed in a graph.

Reactive biomarker for MITOSIS drug and verification result of reactivity with drug

No.	FRH	Variants	Var_Drug (pval)	Var_Exp (Pval)
One	CYR61_1	1_85581605_TA_T	5.27E-05	0.000620768
2	MYB_1	6_135201764_A_C	0.000110474	0.008038119
3	MYH9_1	22_36302635_A_C	0.000236116	0.040823397
4	SNX24_1	5_123023772_TA_T	0.00028033	0.010215104
5	CHAF1A_1	19_4442532_T_C	0.000284751	0.010330163
6	CASP8AP2_1	6_89846678_CT_C	0.000313931	0.000126501
7	MTF2_1	1_93137118_TA_T	0.000462823	0.036903175
8	EGFR_1	7_55170771_T_G	0.000668389	0.004588325
9	ACVR1_1	2_157799371_CA_C	0.000905558	0.016548442
10	MED12_1	X_71132797_T_C	0.000941588	0.024279673
11	TRA2B_1	3_185921167_T_C	0.001087771	0.003158761
12	CYB5R3_1	22_42619486_G_T	0.001094814	0.002582708
13	NFX1_1	9_33303208_A_G	0.001100893	0.023431449
14	UACA_1	15_70669470_GA_G	0.001412253	0.03571568
15	MOK_1	14_102304907_T_C	0.001776612	0.001629205
16	RNF138_1	18_32123591_T_C	0.001798779	0.018606829
17	NMT2_1	10_15119275_A_C	0.002227268	0.015194231
18	DLG2_1	11_83980458_A_G	0.002667354	0.014824348
19	RIN2_1	20_19990244_G_A	0.002695061	0.013004393
20	DHX15_1	4_24540080_CT_C	0.003782084	0.012007783
21	CD276_1	15_73702902_T_G	0.00386155	0.020273648
22	HDAC2_1	6_113944423_T_C	0.004344928	0.041935697
23	PIAS4_1	19_4039058_G_C	0.005375712	0.037776153
24	ARHGAP15_1	2_143216291_G_A	0.005719356	0.035966273
25	STRBP_1	9_123266116_C_G	0.006459968	0.001078377
26	MYO1C_1	17_1484178_C_T	0.007569353	0.007802374
27	EPB41_1	1_29015578_GA_G	0.007616579	0.046541231
28	PRDM2_1	1_13823349_T_A	0.00796288	0.011003429
29	MDM4_1	1_204536848_GA_G	0.008010095	0.021420681
30	C1R_1	12_7091679_A_C	0.00873535	0.0246229
31	RGS16_1	1_182600365_T_G	0.009039587	0.036240935
32	KIFC3_1	16_57765532_T_G	0.009062011	0.038497261
33	NOTCH2_1	1_119922384_T_A	0.009876287	0.022769433
34	PRPF38A_1	1_52416794_T_G	0.012365097	0.004382879
35	U2AF1_1	21_43093000_GT_G	0.018718881	0.003527509
36	FNDC3B_1	3_172328905_GT_G	0.019450759	1.78E-05
37	ITPRIPL1_1	2_96325641_T_G	0.024457637	0.004828474
38	PRKCB_1	16_24174494_CT_C	0.029704271	0.000670802
39	GMEB1_1	1_28702335_T_A	0.031116839	0.003887013
40	IL6ST_1	5_55960635_CT_C	0.045023867	0.00567988
41	SRGAP1_1	12_64142411_T_C	0.046097342	0.006505853
42	DNMT1_1	19_10162649_G_A	0.048749303	0.001347433
43	NPC1_2	18_23540944_CT_C / 18_23539283_G_A	0.00011218638512848764 / 6.166244499849825e-05	0.040822963170832685 / 0.020956228007299703
44	KDM2B_2	12_121579943_C_CA / 12_121534367_T_A	0.0002469480356989407 / 0.00024928370737718086	0.01794421156168876 / 0.01671856514998881
45	MET_3	7_116740945_T_G / 7_116757685_T_G / 7_116795676_T_G	0.00037055097855276256 / 0.003772251227706767 / 0.04454843008676103	0.00017295700570667475 / 5.0554093231126755e-05 / 0.0006156874780574698
46	WWTR1_2	3_149669685_C_T / 3_149669894_G_A	0.0006147608436462098 / 0.0050779807840600905	0.040303211258058205 / 0.014886977556994025
47	RPRD2_2	1_150470594_A_C / 1_150473591_C_T	0.0006254084658607492 / 0.029513176305296374	0.04999439760188915 / 0.008299610316019734
48	PHIP_9	6_78946845_A_T / 6_78965984_A_G / 6_78947674_G_A / 6_78954723_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C	0.0007025290839441325 / 0.0008446291153155781 / 0.010121938819521418 / 0.017201835088518632 / 0.014930588444064525 / 0.02454094082336056 / 0.009915783788926756 / 0.0023583595976247713 / 0.011026610846676282	0.0325055100647953 / 0.0325055100647953 / 0.0010048550446085317 / 0.00648756713202656 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912
49	USP37_2	2_218485635_CAAAA_C / 2_218455538_T_G	0.0008931966771009113 / 0.00047307780771944745	0.04869664909579453 / 0.006248282014078397
50	RRAS_3	19_49636811_C_T / 19_49636835_G_A / 19_49636989_C_A	0.0012180086241795427 / 0.0008453114718541902 / 0.00389443225116509	0.011066495702872568 / 0.008806050890865063 / 0.010977696307794636
51	SHPRH_7	6_145910334_C_A / 6_145922445_C_T / 6_145923607_A_G / 6_145947487_T_A / 6_145948270_A_C / 6_145955343_T_G / 6_145922945_GT_G	0.0015751671472739686 / 0.008305307007300559 / 0.003356044877090312 / 0.00413644978183887 / 0.009574107378650136 / 0.0002467850170635296 / 0.0028322412885894953	0.0007641881109242402 / 0.0008695206428685066 / 0.0004025103622500861 / 0.0002754715942379004 / 0.020534325332750382 / 0.0019437040989644704 / 0.0032085441168495693
52	LAMB2_2	3_49132472_A_C / 3_49126013_T_G	0.0017423458459882547 / 0.041025181157896495	0.0019625130257961386 / 0.002569958840604656
53	THRAP3_2	1_36288866_G_C / 1_36282396_ATTT_A	0.0020512788997300887 / 0.0016248690625818355	0.0001317384338547229 / 0.04220913139330165
54	CTNNA1_2	5_138932696_A_G / 5_138932714_T_G	0.002692413567981528 / 0.005472909098268261	0.007557173168109447 / 0.0016091365079487266
55	TAPT1_2	4_16162866_G_A / 4_16202603_GA_G	0.002918386893883101 / 0.000914379509289869	0.000763966557961968 / 0.0004886648390188492
56	SLC35F5_3	2_113717856_GA_G / 2_113742699_CA_C / 2_113723196_TA_T	0.003014076668232333 / 0.005012402765669162 / 0.0170410099009839	0.01701812431912492 / 6.159712513106605e-06 / 0.009792441988171948
57	CCAR1_3	10_68737016_C_A / 10_68747145_CT_C / 10_68760969_CT_C	0.00325467857819848 / 0.025692165325181263 / 0.0016743825966123902	0.003954046326130957 / 0.007417608363424872 / 0.007417608363424872
58	TADA1_2	1_166858437_T_C / 1_166869276_TA_T	0.003257661220538658 / 0.007643004397209361	0.012600985482671512 / 0.00358370659710894
59	SAFB_2	19_5668433_GT_G / 19_5653276_T_G	0.0039066263073592 / 0.0014480393694902619	0.0026106809691974946 / 0.018733735357902476
60	LEPROTL1_2	8_30105682_AT_A / 8_30156243_A_C	0.005708636597504029 / 0.014522072472209685	0.02256500634957293 / 3.3209275234199355e-06
61	SQSTM1_3	5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C	0.005980563650762417 / 9.139203270628232e-06 / 0.04751023288058377	0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784
62	PLEC_10	8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143975295_A_G / 8_143919088_C_G / 8_143925285_C_T / 8_143927138_G_A / 8_143	0.006797512530240399 / 0.023847093097519808 / 0.003689478164571844 / 0.04007075765894598 / 0.03700251313887589 / 0.004544202282444686 / 0.03720602259473315 / 0.00047050570860322235 / 4.768364655899894e-05 / 0.0001893462141118206	0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.039226625991533134 / 0.009415988048366521 / 0.005460087145469642 / 0.008162873576760793 / 0.001268625363946227
63	CTSA_2	20_45893486_C_CT / 20_45894873_G_C	0.006806775220314732 / 0.009189197205389115	0.0011092438036515453 / 2.1137755776974608e-05
64	RND3_2	2_150471770_GA_G / 2_150487464_GA_G	0.006850825677580675 / 0.002608896214858801	0.004413096667547799 / 0.009852344084866441
65	DOCK1_3	10_127409601_G_A / 10_127248143_T_C / 10_127248024_G_T	0.0069346786852210966 / 0.001954876992257982 / 0.00010052759289672492	0.021839153568346648 / 0.030500963727912844 / 0.020184142497530616
66	MYOF_2	10_93341723_C_T / 10_93379679_T_C	0.007420864833221702 / 0.007547951219247403	1.0154009952651607e-05 / 0.0006543495060757152
67	PDS5B_2	13_32758091_C_T / 13_32675925_C_A	0.0075589035603876795 / 0.0017607048342993868	0.0023301391981286807 / 0.004241708828197667
68	HEXB_3	5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A	0.007745014587458687 / 4.786425040147315e-06 / 8.479985392616748e-06	0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071
69	TANC1_2	2_159136061_C_T / 2_159174959_G_C	0.00802472531176929 / 0.006460757964179747	0.017357470848779515 / 0.02749828370491698
70	ASPH_2	8_61642872_G_A / 8_61638365_TA_T	0.009092096160092012 / 2.1941312888430133e-05	9.242250914202104e-05 / 0.0033421074285719613
71	GSN_2	9_121326794_T_G / 9_121318750_T_C	0.009209877230841344 / 0.005427091425517584	0.014858234163842209 / 0.01549301533305157
72	ZNF292_3	6_87258847_A_G / 6_87260583_C_G / 6_87257934_G_C	0.0095880085401273 / 0.002653056510702511 / 0.037301685006945806	0.03664575782437445 / 0.02762172574455939 / 1.3565314335396872e-05
73	DTNBP1_2	6_15662660_G_A / 6_15651411_GA_G	0.016540725603977957 / 0.0034858875216863218	0.005994085134454578 / 0.0014349866138238813
74	SUGP2_2	19_19025732_C_T / 19_19008374_A_C	0.023033529177264773 / 0.0007995182905667767	0.008182273259557721 / 0.003040780848236827
75	ARID1B_5	6_157084627_G_A / 6_157084796_G_A / 6_156935454_GT_G / 6_156779132_C_G / 6_157206255_A_C	0.023572130650620228 / 0.0065953837312734045 / 0.00024483625735866694 / 0.0017474661626312965 / 0.008386743713695547	0.002480449952777213 / 0.003319459056638543 / 0.031030935390966245 / 0.0436791475273224 / 0.02302848816217332
76	DAZAP1_3	19_1432575_T_C / 19_1432578_A_C / 19_1421326_T_G	0.025717426655995912 / 0.012380456372647609 / 0.005697517435006497	0.008783799588482919 / 0.004625103934387489 / 0.03399063425366008
77	FAM76B_2	11_95786079_T_C / 11_95787545_T_C	0.026712661661121014 / 0.007093482411673812	0.008842917440325095 / 0.006738523037696958
78	CNTRL_3	9_121175323_T_C / 9_121167492_C_T / 9_121123912_AT_A	0.02777922136116125 / 0.03429035595633583 / 0.009987376618823514	0.008182636643218607 / 0.0016137010941682265 / 0.04001035208622377
79	IQCB1_4	3_121788384_A_T / 3_121807190_T_G / 3_121781663_A_T / 3_121781662_C_A	0.02873631298848243 / 0.04311975747619515 / 0.0034541658078948746 / 0.0008249500332497977	0.0011523884052119758 / 0.0035712731344638405 / 0.03680371502100786 / 0.031208890653500118
80	RRBP1_2	20_17636886_T_C / 20_17643440_G_A	0.03507251839152679 / 0.01991260739356573	1.9056892828600246e-06 / 0.0037236305333221867
81	ZNF84_2	12_133048690_A_T / 12_133048009_C_G	0.037210990330289934 / 0.040160599243354515	0.0028259388562976405 / 0.008314464537214374
82	MYCBP2_2	13_77098982_T_G / 13_77061586_T_C	0.03744183774757608 / 0.00310540257860121	0.0038229074053839733 / 0.030373685856290068
83	CALD1_3	7_134933124_A_G / 7_134891710_CTT_C / 7_134941283_GAAA_G	1.0681523332046643e-06 / 0.0055155972985149685 / 0.0008159520917689481	0.034156156662500686 / 0.006749784168432884 / 0.007042501841739691
84	RBMX_5	X_136874303_G_C / X_136874308_C_T / X_136876571_C_A / X_136880660_G_A / X_136879426_ATG_A	5.449363562924237e-05 / 3.4887046700057416e-07 / 6.172396284131506e-05 / 0.0054727241117358974 / 0.005573036956662709	0.0383480406291467 / 0.029837740684056712 / 0.015245783387880662 / 0.03540981223032282 / 0.0056729536604581
85	POLR2B_3	4_57005538_CA_C / 4_57023798_AT_A / 4_57024870_CT_C	5.482928793734288e-06 / 0.02167722586394588 / 0.0009543180256774695	0.018564114826717992 / 0.007472844031288456 / 0.0012756499136273938
86	SECISBP2_3	9_89319872_A_G / 9_89325866_A_T / 9_89348180_T_G	6.195560569127674e-05 / 0.0006584940331716795 / 0.0021577193257759702	0.020014055406942226 / 0.00642217291639139 / 0.01739212501206905
87	FBXO41_2	2_73258961_C_G / 2_73264474_A_C	7.08184621839895e-05 / 0.008886058285019023	0.010646018841909207 / 0.014910469893708134
88	TSPAN4_2	11_844057_C_G / 11_865650_C_G	8.251559449584364e-05 / 0.0042898689776822594	0.04166717005266338 / 0.02401170518473186

On the other hand, Fig. 23 shows a method of manufacturing a test chip used for biomarker detection for the co-diagnosis of drugs for 6 cancer types summarized in [Table 1] and 6 drug types summarized in [Table 14]. It is done.

As shown in FIG. 23, in the first step, a diagnostic chip for each biomarker for the cancer type and drug type specified in [Table 1] and [Table 14] is produced, or the cancer type and drug type All of the biomarkers for or all of them are made of one chip, and for the FRH marker associated with the drug type or cancer type from the patient, the illustrated example of FIG. 18 (EGFR pathway, one of the drug types of blood cancer) ) Using a set of FRHs that are highly related to drug response and total FRHs that are highly related to a specific cancer, the drug reactivity can be predicted by generating a linear regression prediction model of FIG. 20. Accordingly, various cancer and cancer drug companion diagnostic chips can be manufactured and utilized as shown in FIG. 23 using FRH biomarkers specific to the six cancer types (CancerClass) and six drug types (DrugClass) summarized in this patent.

Based on the results verified in [Table 2] to [Table 20], the significant biomarker composition is examined in each case.

First, in summary for biomarker compositions for determining reactivity to blood cancer drugs, each of the markers disclosed in [Table 2] was calculated to be significant, and among these markers, markers associated with MYB gene expression 13_37746458_AA_A, 16_46710765_T_A, 1_63382198_CA_C , 14_68477626_CT_C and 7_151221500_CT_C were analyzed as major marker combinations.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 2] in addition to the aforementioned markers.

Next, to summarize the biomarker composition for determining the reactivity to female cancer drugs, each of the markers disclosed in [Table 4] was calculated to be significant, and among these markers, markers 1_13248174_T_C (marker 1) associated with IRX5 gene expression ), 16_85071785_A_G (marker 2) and 9_34371054_A_C (marker 3) were analyzed as the major marker combinations.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 4] in addition to the aforementioned markers.

And in summary for biomarker compositions for determining the reactivity to brain tumor drugs, each marker disclosed in [Table 6] was calculated to be significant, and among these markers, markers associated with PTRF gene expression 11_12162199_T_G (Marker 1), 13_113159942_A_G (Marker 2), 5_181155466_T_G (Marker 3), 11_65547388_T_G (Marker 4), 10_11921140_T_G (Marker 5), 17_55774876_T_G (Marker 6), 12_40313960_G_T (Marker 7), 16_1817242_T_C (Marker 8) Was analyzed.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 6] in addition to the aforementioned markers.

In addition, to summarize the biomarker composition for determining the reactivity to the head and neck cancer drug, each marker disclosed in [Table 8] was calculated to be significant, and among these markers, markers related to RAI14 gene expression 14_21082261_T_G (Marker 1) And 7_140753336_A_T (Marker2) were analyzed as the main marker combination.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 8] in addition to the aforementioned markers.

And in summary for biomarker compositions for determining the reactivity to lung cancer drugs, each of the markers disclosed in [Table 10] was calculated to be significant, and among these markers, markers associated with POLR3K gene expression 2_217847583_C_T (Marker 1), 2_71424561_G_GT (Marker 2), 2_217847883_G_A (Marker 3), 2_217848003_A_G (Marker 4) and 17_81206909_A_C (Marker 5) were analyzed as the major marker combinations.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 10] in addition to the aforementioned markers.

In addition, to summarize the biomarker composition for determining the reactivity to sarcoma cancer drugs, each of the markers disclosed in [Table 12] was calculated to be significant, and among these markers, marker 1_26457907_T_G (marker 1) associated with LUC7L gene expression , 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4) and 22_18847351_G_C (marker 5) were analyzed as the major marker combinations.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 10] in addition to the aforementioned markers.

And in summary for biomarker compositions for determining the reactivity to ABL drugs, each of the markers disclosed in [Table 15] was calculated to be significant, and among these markers, the markers 15_59223315_G_A and HMGB1 were associated with gene expression. Marker 13_30465849_T_C was analyzed as the main marker combination.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 15] in addition to the aforementioned markers.

In addition, to summarize the biomarker composition for determining the responsiveness to CHROMATIN drug, each marker disclosed in [Table 16] was calculated to be significant, and among these markers, markers 2_72891611_A_C and ERRFI1 associated with SPR gene expression Associated markers 1_8013331_A_G were analyzed as the major marker combination.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 16] in addition to the aforementioned markers.

And in summary for biomarker compositions, for determining responsiveness to EGFR drugs, each of the markers disclosed in [Table 17] was calculated to be significant, and among these markers were associated with marker 9_111597344_C_A and HDHD2 gene expression associated with PTGR1 gene expression. Markers 18_47115026_C_T were analyzed for major marker combinations.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 17] in addition to the aforementioned markers.

In addition, to summarize the biomarker composition for determining the reactivity to the ERK_MAPK drug, each marker disclosed in [Table 18] was calculated to be significant, and among these markers, 5_142319698_T_G and DUSP6 gene expression associated with SPRY4 gene expression Associated markers 12_89350540_G_A were analyzed as the major marker combination.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 18] in addition to the aforementioned markers.

And in summary for biomarker compositions for determining the reactivity to IGFR drugs, each of the markers disclosed in Table 19 was calculated to be significant, and among these markers, the markers X_119618658_T_G and EPHA2 associated with SEPT6 gene expression were associated Markers 1_16148437_A_C were analyzed as the main marker combination.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 19] in addition to the aforementioned markers.

In addition, to summarize the biomarker composition for determining the reactivity to the MITOSIS drug, each of the markers disclosed in [Table 20] was calculated to be significant, and among these markers, markers 1_85581605_TA_T and MYB associated with CYR61 gene expression and Associated marker 6_135201764_A_C was analyzed with the main marker combination.

Of course, the above biomarker composition according to the present invention may be configured by various combinations by further including the biomarkers disclosed in [Table 20] in addition to the aforementioned markers.

Explanation of terms

In the present invention, the definition of the drug type (DrugClass) is a type of drug targets and a functionally similar functional type of drug, or a gene group, drug pathway, or drug signaling of a category in which the drug is affected. Pathway (drug signaling pathway), etc. are all termed as a generic drug type (DrugClass). FRH is a term for functionally related relative haplotype, eQTL is a term for expression quantitative trait loci for expression, and FRH (Exp | IC50) is over / under ) The term indicates the average value of IC50 for the expressed cluster, FRH (CNV | IC50) is the term indicating the average value of IC50 for the amplification / deletion cluster, and FRH (loci | IC50) is the given loci The term for the average value of IC50 for the type cluster, GDSC is the term for Genomics of Drug Sensitivity in Cancer, CCLP is the term for COSMIC Cell Lines Project, and the web page is http://cancer.sanger.ac.uk/cell_lines As can be seen from, CNV is a term for copy number variation, GBLscan is a term for Cancer Biomarker Labeling Scan, and ISCT stands for In Silico Clinical Trial. It is a term.

The rights of the present invention are not limited to the embodiments described above, but are defined by the claims, and those skilled in the art can make various modifications and adaptations within the scope of the claims. It is self-evident.

The present invention is a novel linear regression model that can reliably predict drug responsiveness by combining analysis of disease-specific specific gene mutation fingerprints including cancer and molecular pharmacological functional groups of drugs, drug indications and response prediction systems, and The method relates to GBLscan (Genetic Biomarker Scan), and according to the present invention, in the present invention, the degree of reactivity of the drug with a genome whose pharmacological effect is unknown from the results of drug reactivity to the genome collected from in vitro and in vivo clinical trials There is an effect that can be predicted.

Claims (36)

1. In order to determine the responsiveness to blood cancer drugs, in the biomarker composition consisting of a combination of markers containing a mutation that modulates gene expression,

   The biomarker composition,

   Biomarker composition for the determination of cancer drug responsiveness, comprising 13_37746458_AA_A (marker 1), 16_46710765_T_A (marker 2), 11_63382198_CA_C (marker 3), 14_68477626_CT_C (marker 4) and 7_151221500_CT_C (marker 5).
2. In order to determine the reactivity to the blood cancer drug, by detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the blood cancer drug,

   The biomarker composition,

   13_37746458_AA_A (marker 1), 16_46710765_T_A (marker 2), 11_63382198_CA_C (marker 3), 14_68477626_CT_C (marker 4) and 7_151221500_CT_C (marker 5) comprises a method for determining cancer drug reactivity using a biomarker composition.
3. In order to determine the responsiveness to a blood cancer drug, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a mutation that controls gene expression,

   The detection target, the biomarker composition,

   Diagnostic chip for detecting biomarker composition for cancer drug reactivity determination, comprising 13_37746458_AA_A (marker 1), 16_46710765_T_A (marker 2), 11_63382198_CA_C (marker 3), 14_68477626_CT_C (marker 4) and 7_151221500_CT_C (marker 5) .
4. In order to determine the responsiveness to a female cancer drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

   The biomarker composition,

   Biomarker composition for cancer drug reactivity determination, characterized in that it comprises 1_13248174_T_C (marker 1), 16_85071785_A_G (marker 2) and 9_34371054_A_C (marker 3).
5. In order to determine the responsiveness to a female cancer drug, in a method of determining a responsiveness to a female cancer drug by detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

   The biomarker composition,

   1_13248174_T_C (marker 1), 16_85071785_A_G (marker 2) and 9_34371054_A_C (marker 3) method for determining cancer drug reactivity using a biomarker composition.
6. In order to determine the responsiveness to female cancer drugs, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a mutation that controls gene expression,

   The detection target, the biomarker composition,

   1_13248174_T_C (marker 1), 16_85071785_A_G (marker 2) and 9_34371054_A_C (marker 3) diagnostic chip for detecting biomarker composition for cancer drug reactivity determination.
7. In order to determine the reactivity to the brain tumor drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression,

   The biomarker composition,

   11_12162199_T_G (marker 1), 13_113159942_A_G (marker 2), 5_181155466_T_G (marker 3), 11_65547388_T_G (marker 4), 10_11921140_T_G (marker 5), 17_55774876_T_G (marker 6), 12_40359_T_G (12) Biomarker composition for determining cancer drug responsiveness, characterized in that it comprises a marker 9).
8. In order to determine the reactivity to a brain tumor drug, in a method of detecting a biomarker composition composed of a combination of markers containing a variation that regulates gene expression, to determine the reactivity to a brain tumor drug,

   The biomarker composition,

   11_12162199_T_G (marker 1), 13_113159942_A_G (marker 2), 5_181155466_T_G (marker 3), 11_65547388_T_G (marker 4), 10_11921140_T_G (marker 5), 17_55774876_T_G (marker 6), 12_40359_T_G (12) Cancer drug reactivity determination method using a biomarker composition characterized in that it comprises a marker 9).
9. In order to determine the responsiveness to a brain tumor drug, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a mutation that controls gene expression,

   The detection target, the biomarker composition,

   11_12162199_T_G (marker 1), 13_113159942_A_G (marker 2), 5_181155466_T_G (marker 3), 11_65547388_T_G (marker 4), 10_11921140_T_G (marker 5), 17_55774876_T_G (marker 6), 12_40359_T_G (12) Diagnostic chip for detecting biomarker composition for cancer drug responsiveness, characterized in that it comprises a marker (9).
10. In order to determine the reactivity to the head and neck cancer drug, in the biomarker composition consisting of a combination of markers containing a variation that modulates gene expression,

    The biomarker composition,

    14_21082261_T_G (marker 1) and 7_140753336_A_T (marker 2) biomarker composition for determining the reactivity of cancer drugs, characterized in that comprises a.
11. In order to determine the reactivity to the head and neck cancer drug, by detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the head and neck cancer drug,

    The biomarker composition,

    14_21082261_T_G (marker 1) and 7_140753336_A_T (marker 2) cancer drug reactivity determination method using a biomarker composition characterized in that it comprises a.
12. In order to determine the reactivity to the head and neck cancer drug, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression,

    The detection target, the biomarker composition,

    14_21082261_T_G (marker 1) and 7_140753336_A_T (marker 2) diagnostic chip for detecting biomarker composition for cancer drug responsiveness, characterized in that it comprises.
13. In order to determine the responsiveness to lung cancer drugs, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    Biomarker composition for cancer drug reactivity determination comprising 2_217847583_C_T (marker 1), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4) and 17_81206909_A_C (marker 5).
14. In order to determine the reactivity to the lung cancer drug, in a method of determining a reactivity to the lung cancer drug by detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    2_217847583_C_T (marker 1), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4) and 17_81206909_A_C (marker 5) comprising the method of determining the drug drug responsiveness using a biomarker composition.
15. In order to determine the responsiveness to lung cancer drug, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression,

    The detection target, the biomarker composition,

    Diagnostic chip for detecting biomarker composition for cancer drug reactivity determination, comprising 2_217847583_C_T (marker 1), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4) and 17_81206909_A_C (marker 5) .
16. In order to determine the responsiveness to a sarcoma cancer drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    Biomarker composition for the determination of cancer drug reactivity, comprising 1_26457907_T_G (marker 1), 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4) and 22_18847351_G_C (marker 5).
17. In order to determine the reactivity to a sarcoma cancer drug, by detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to a sarcoma cancer drug,

    The biomarker composition,

    A method for determining cancer drug reactivity using a biomarker composition comprising 1_26457907_T_G (marker 1), 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4), and 22_18847351_G_C (marker 5).
18. In order to determine the responsiveness to a sarcoma cancer drug, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

    The detection target, the biomarker composition,

    Diagnostic chip for detecting biomarker composition for cancer drug reactivity determination, comprising 1_26457907_T_G (marker 1), 22_22643666_C_G (marker 2), 22_21127217_C_G (marker 3), 5_141432375_A_C (marker 4) and 22_18847351_G_C (marker 5) .
19. In order to determine the responsiveness to ABL drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    15_59223315_G_A (marker 1) and 13_30465849_T_C (marker 2) biomarker composition for determining cancer drug responsiveness.
20. In order to determine the reactivity to the ABL drug, in a method of determining a reactivity to the ABL drug by detecting a biomarker composition composed of a combination of markers containing a mutation that controls gene expression,

    The biomarker composition,

    15_59223315_G_A (marker 1) and 13_30465849_T_C (marker 2) cancer drug responsiveness determination method using a biomarker composition characterized in that it comprises a.
21. In order to determine the responsiveness to ABL drug, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing a mutation that controls gene expression,

    The detection target, the biomarker composition,

    15_59223315_G_A (marker 1) and 13_30465849_T_C (marker 2) diagnostic chip for detecting biomarker composition for cancer drug reactivity determination, characterized in that it comprises.
22. In order to determine the responsiveness to CHROMATIN drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    Biomarker composition for determining cancer drug responsiveness, characterized in that it comprises 2_72891611_A_C (marker 1) and 1_8013331_A_G (marker 2).
23. In order to determine the reactivity to the CHROMATIN drug, by detecting a biomarker composition composed of a combination of markers containing a variation that modulates gene expression, to determine the reactivity to the CHROMATIN drug,

    The biomarker composition,

    2_72891611_A_C (marker 1) and 1_8013331_A_G (marker 2) cancer drug reactivity determination method using a biomarker composition characterized in that it comprises a.
24. In order to determine the responsiveness to CHROMATIN drug, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The detection target, the biomarker composition,

    Diagnostic chip for biomarker composition detection for cancer drug reactivity determination, characterized in that it comprises 2_72891611_A_C (marker 1) and 1_8013331_A_G (marker 2).
25. In order to determine the responsiveness to the EGFR drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    9_111597344_C_A (marker 1) and 18_47115026_C_T (marker 2) biomarker composition for determining cancer drug responsiveness comprising a.
26. In order to determine the responsiveness to the EGFR drug, by detecting a biomarker composition consisting of a combination of markers containing a variation that modulates gene expression, to determine the responsiveness to the EGFR drug,

    The biomarker composition,

    9_111597344_C_A (marker 1) and 18_47115026_C_T (marker 2) cancer drug reactivity determination method using a biomarker composition characterized in that it comprises a.
27. In order to determine the responsiveness to the EGFR drug, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The detection target, the biomarker composition,

    9_111597344_C_A (marker 1) and 18_47115026_C_T (marker 2) diagnostic chip for detecting biomarker composition for cancer drug responsiveness, characterized in that it is configured.
28. In order to determine the reactivity to the ERK_MAPK drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    5_142319698_T_G (marker 1) and 12_89350540_G_A (marker 1) biomarker composition for cancer drug reactivity determination, characterized in that comprises a.
29. In order to determine the reactivity to the ERK_MAPK drug, a method for determining the reactivity to the ERK_MAPK drug by detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    5_142319698_T_G (marker 1) and 12_89350540_G_A (marker 1) cancer drug reactivity determination method using a biomarker composition characterized in that it comprises a.
30. In order to determine the responsiveness to ERK_MAPK drug, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

    The detection target, the biomarker composition,

    5_142319698_T_G (marker 1) and 12_89350540_G_A (marker 1) diagnostic chip for detecting biomarker composition for cancer drug reactivity determination, characterized in that it comprises.
31. In order to determine the responsiveness to the IGFR drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    Biomarker composition for determining cancer drug responsiveness, characterized in that it comprises X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2).
32. In order to determine the reactivity to the IGFR drug, in a method of determining a reactivity to the IGFR drug by detecting a biomarker composition composed of a combination of markers containing a mutation that modulates gene expression,

    The biomarker composition,

    X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2) cancer drug reactivity determination method using a biomarker composition characterized in that it comprises a.
33. In order to determine the responsiveness to the IGFR drug, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The detection target, the biomarker composition,

    Diagnostic chip for detecting biomarker composition for cancer drug reactivity determination, characterized in that it comprises X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2).
34. In order to determine the reactivity to the MITOSIS drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    Biomarker composition for determining cancer drug responsiveness, characterized in that it comprises 1_85581605_TA_T (marker 1) and 6_135201764_A_C (marker 2).
35. In order to determine the reactivity to the MITOSIS drug, in a method of determining a reactivity to the MITOSIS drug by detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

    The biomarker composition,

    1_85581605_TA_T (marker 1) and 6_135201764_A_C (marker 2), characterized in that the cancer drug responsiveness determination method using a biomarker composition.
36. In order to determine the responsiveness to MITOSIS drug, in a diagnostic chip for detecting a biomarker composition composed of a combination of markers containing mutations that regulate gene expression,

    The detection target, the biomarker composition,

    1_85581605_TA_T (marker 1) and 6_135201764_A_C (marker 2) diagnostic chip for detecting biomarker composition for cancer drug responsiveness, characterized in that it is configured.

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