WO2020060397A1 - Tissue transfer device - Google Patents

Tissue transfer device Download PDF

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Publication number
WO2020060397A1
WO2020060397A1 PCT/NL2019/050608 NL2019050608W WO2020060397A1 WO 2020060397 A1 WO2020060397 A1 WO 2020060397A1 NL 2019050608 W NL2019050608 W NL 2019050608W WO 2020060397 A1 WO2020060397 A1 WO 2020060397A1
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WO
WIPO (PCT)
Prior art keywords
wall sections
tissue
transfer device
proximal end
distal end
Prior art date
Application number
PCT/NL2019/050608
Other languages
French (fr)
Inventor
Aimée SAKES
Paulus Breedveld
Original Assignee
Technische Universiteit Delft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universiteit Delft filed Critical Technische Universiteit Delft
Publication of WO2020060397A1 publication Critical patent/WO2020060397A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B17/3421—Cannulas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
    • A61B2017/00398—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like using powered actuators, e.g. stepper motors, solenoids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00858—Material properties high friction, non-slip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A61B17/32002—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes with continuously rotating, oscillating or reciprocating cutting instruments
    • A61B2017/320024—Morcellators, e.g. having a hollow cutting tube with an annular cutter for morcellating and removing tissue

Definitions

  • the invention relates to a tissue transfer device com prising a tubular structure with a lumen, wherein the lumen is arranged between a proximal end and a distal end of the device, and wherein tissue is transportable between the distal end and the proximal end.
  • Such a tissue transfer device is known from
  • US2015/0223787 discloses a distant transport trough for tissue, wherein the trough is provided with an extension, and wherein proximally the extension can be rolled to move the trough with the tissue.
  • a tissue transfer device is particu larly applicable in combination with and during or after medical surgery, such as for instance when performing a hysterectomy.
  • a morcella- tor In order to initiate tissue transport out and away from the patient's body, it is also known to use suction or a grasper.
  • suction is used on the lumen of the morcellator' s cutting blade as a driving force for moving the tissue through said lumen of the morcellator. The problems relate to obstructions hindering the tissue removal from the pa tient's body, due to
  • the length of the lu men that is the length of the hollow cutting blade and/or any longitudinal tube connected thereto for further transporting the tissue, restricts the possibilities to remove tissue, since the differential pressure between the proximal end and the distal end is limited to the barometric pressure.
  • This aspect also re stricts miniaturization of the known device and does not allow sufficient length of the device in some applications.
  • tissue transfer device is proposed in accordance with one or more of the appended claims.
  • the tubular struc ture of the tissue transfer device is provided with longitudi nally movable wall sections, and that said wall sections are in dividually back and forth movable in the longitudinal direction of the device, wherein the device is arranged such that during transport of tissue between the distal end and the proximal end, first wall sections assume a repetitious cycle of longitudinally moving in the direction of the proximal end and back, and second wall sections assume a repetitious shifted cycle with reference to the motions of the first wall sections such that while the first wall sections move in the direction of the proximal end and back, the second wall sections longitudinally move in the direction of the distal end and forth, wherein the first wall sections and the second wall sections exert in absolute terms mutually different frictional forces on the tissue.
  • tissue transfer device of the invention With the construction of the tissue transfer device of the invention the need to use suction or a grasper is avoided, and the tissue transport is not adversely affected by the slen derness of the construction of the device.
  • the tissue transfer device of the invention can be used on a very broad range of tissue types, including bone and fat tissue. It is even possible to construe the longitudinally movable wall sections of the de vice to make it flexible and capable to follow bends. It is also possible to make the device steerable.
  • tissue transfer device is highly versatile, which follows from the many optional embodiments that are feasible as men- tioned hereinafter.
  • the wall sections are selected from the group comprising cables, rods, tubes, glassfibres or combinations thereof. Since the group is not limited also other embodiments are feasible.
  • the wall sections are provided with one or more shapes selected from the group comprising round, square, rectangular, or triangular or combinations thereof. Since also this group is not limited other shapes are feasible as well.
  • first and second wall sections have mutually different dimensions to provide that, because of the different dimensions which imply different contact areas with the tissue, these wall sections will exert mutually different frictional forces on the tissue.
  • first and second wall sections have mutually different surface properties or claddings or structures to provide that these wall sections exert mutually different frictional forces on the tissue.
  • the first and second wall sections move at mutually different speeds and/or accelerations, which will then affect the frictional forces that will be applied on the tissue by the respective first and second wall sections.
  • first wall sections and the second wall sections differ in number.
  • a preselected first number of wall sections cyclically moves in the direction of the proximal end and back, and a pre selected second number of wall sections longitudinally moves in the direction of the distal end and forth, wherein the first number is higher than the second number in case it is desired that the tissue moves towards the proximal end and lower in case it is desired that the tissue moves towards the distal end.
  • a straightforward and relatively simple sub-embodiment of the fourth embodiment is that when the wall sections are mu tually identical the first number and the second number add up to a total of at least three longitudinally movable wall sec tions .
  • An advantage of this sub-embodiment of the fourth em bodiment is that it is already possible to provide an effective transfer device by arranging that the first number and the sec ond number of the longitudinally movable wall sections add up to a total of at least three.
  • the first number is four and the second number is two, so the total number of movable wall sections is then six.
  • the tubular structure comprises an outer tube wherein the longitudinally movable wall sections are at least in part contained. In this manner interference of the longitudinally movable wall sections with the tissue remaining in the patient's body can be effectively avoided.
  • the tissue transfer device of the invention is suitably embodied such that the device comprises a motor drive at the proximal end for individually driving the longitudinally movable wall sections.
  • the device comprises a motor drive at the proximal end for individually driving the longitudinally movable wall sections.
  • the device could well func tion when it would be manually driven as can be noted from the main claim which does not specify how the wall sections are driven .
  • the invention will hereinafter be further elucidated with reference to the drawing of an exemplary embodiment of a tissue transfer device according to the invention that is not limiting as to the appended claims. For the purpose of this ex planation and for reasons of simplicity reference is made to the above-mentioned fourth embodiment.
  • -figure 1 shows a perspective view at a tissue transport device according to the invention in an experimental setup
  • FIG. 1 shows a side view of the tissue transport de vice according to figure 1;
  • FIG. 3 shows a sequence of events in a first embodi ment of the tissue transfer device of figure 1;
  • FIG. 4 shows a sequence of events in a second embod iment of the tissue transfer device of figure 1.
  • FIG. 1 shows an experimental setup of a tissue transport device 1 according to a fourth embodiment of the in vention.
  • This tissue transport device 1 comprises a tubular structure 2 with a lumen 3.
  • the lumen 3 is arranged between a proximal end 5 and a distal end 4 of the device 1 which may be better seen in figure 2.
  • the distal end 4 is during use located in the patient's body for picking up the tissue to be removed.
  • the device 1 according to this fourth embodiment is de signed to transport tissue from the distal end 4 to the proximal end 5, and for this purpose the tubular structure 2 comprises longitudinally movable wall sections 6.
  • Said wall sections 6 are individually back and forth movable in the longitudinal direc tion of the device 1, such that during transport of tissue from the distal end 4 to the proximal end 5, at any instance during the transport a preselected first number of wall sections longi tudinally moves in the direction of the proximal end 5, and a preselected second number of wall sections 6 stands still or longitudinally moves in the direction of the distal end 4, wherein the first number is higher than the second number.
  • the longitudinally movable wall sections 6 are back and forth movable or reciprocating in order to entertain indeed a continuous movement of the tissue from the distal end 4 to the proximal end 5 of the device 1.
  • the first number and the second number add up to a total of at least three longitudinally movable wall sections 6.
  • the first number is four and the second number is two, so that the total number of longitudi nally movable wall sections 6 counts six.
  • figure 1 shows four wall sections of a first group indicat ed with reference 6' that may act on the tissue to be transport ed by moving towards the distal end 4, whilst in a mode shifted with reference to said first group a second and larger group of wall sections indicated with reference 6' ' that stands still or moves in the direction of the proximal end 5.
  • the resulting force acting on the tissue is that the forces applied by the wall sections 6' ' of the second group will be higher than the forces applied by the wall sections 6' of the first group, which will cause the tissue to move towards the proximal end 5.
  • FIG. 3 A detailed illustration of possible movements of the wall sections 6' of the first group and the wall sections 6' ' of the second group is provided by figure 3, in which each time a single wall section 6' (see f.i. fig. 3b) moves towards the dis tal end 4, and the remaining five wall sections 6'' move in a mutually shifted phase towards the proximal end 5.
  • the wall section 6' ' -h that is closest to the proximal end 5 has reached its farthest position, it stops and changes direction and becomes the next single wall section 6'-c (see fig.
  • Figure 4 shows an alternative embodiment wherein two pairs of wall sections 6' ' move towards the proximal end 5 while one pair of wall sections 6' moves towards the distal end 4.
  • the friction exerted upon the tissue by the wall sections 6' ' is twice as large as the friction exerted by the wall sections 6' .
  • the wall sections belonging to the same pair oppose each other so that the (small) forces of gravity and the amount of surface contact of the wall sections with irregu larly shaped pieces of transportable tissue affect each pair of wall sections equally.
  • Figure 1 further clearly shows a preferable arrangement wherein the tubular structure 2 comprises an outer tube 7 where in the longitudinally movable wall sections 6 are at least in part contained.
  • the device 1 preferably comprises a motor drive 8 at the proximal end 5 for individually driving the longitudinally movable wall sections 6.
  • the wall sections 6 are selected from the group comprising cables, rods, tubes, glassfibres ;
  • the wall sections 6 are provided with a shape se lected from the group comprising round, square, rectangular, or triangular;
  • first and second wall sections 6 have mutual ly different dimensions to provide that these wall sections ex ert mutually different frictional forces on the tissue; -that facing the lumen 3 the first and second wall sec tions 6 have mutually different surface properties or claddings or structures to provide that these wall sections exert mutually different frictional forces on the tissue; and
  • first and second wall sections 6 move during transportation of the tissue at mutually different speeds and/or accelerations .

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  • Life Sciences & Earth Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

Tissue transfer device (1) comprising a tubular structure (2) with a lumen (3), wherein the lumen (3) is arranged between a proximal end (5) and a distal end (4) of the device (1), and wherein tissue is transportable between the distal end (4) and the proximal end (5), wherein the tubular structure (2) com- prises longitudinally movable wall sections (6), and that said wall sections (6) are individually back and forth movable in the longitudinal direction of the device (1), wherein the device (1) is arranged such that during transport of tissue between the distal end (4) and the proximal end (5), first wall sections (6) assume a repetitious cycle of longitudinally moving in the direction of the proximal end (5) and back, and second wall sections (6) assume a repetitious shifted cycle with reference to the motions of the first wall sections (6) such that while the first wall sections (6) move in the direction of the proximal end (5) and back, the second wall sections (6) longitudinally move in the direction of the distal end (4) and forth, wherein the first wall sections (6) and the second wall sections (6) exert in absolute terms mutually different frictional forces on the tissue.

Description

Tissue transfer device
The invention relates to a tissue transfer device com prising a tubular structure with a lumen, wherein the lumen is arranged between a proximal end and a distal end of the device, and wherein tissue is transportable between the distal end and the proximal end.
Such a tissue transfer device is known from
US2010/331883, wherein within the tubular structure one or more wires with tissue adhering material attached thereto or formed therein may be preloaded, and withdrawn one by one during the procedure to remove tissue as it is cut .
US2015/0223787 discloses a distant transport trough for tissue, wherein the trough is provided with an extension, and wherein proximally the extension can be rolled to move the trough with the tissue.
Generally speaking a tissue transfer device is particu larly applicable in combination with and during or after medical surgery, such as for instance when performing a hysterectomy. In a hysterectomy, but also in other surgery wherein tissue is to be removed from a patient's body, use can be made of a morcella- tor. In order to initiate tissue transport out and away from the patient's body, it is also known to use suction or a grasper. There are several problems when suction is used on the lumen of the morcellator' s cutting blade as a driving force for moving the tissue through said lumen of the morcellator. The problems relate to obstructions hindering the tissue removal from the pa tient's body, due to
-diameter expansion of the tissue after resection
-accumulated friction within the hollow cutting blade -jamming of tissue
-coagulation, etc.
It is furthermore a problem that the length of the lu men, that is the length of the hollow cutting blade and/or any longitudinal tube connected thereto for further transporting the tissue, restricts the possibilities to remove tissue, since the differential pressure between the proximal end and the distal end is limited to the barometric pressure. This aspect also re stricts miniaturization of the known device and does not allow sufficient length of the device in some applications.
It is an object of the invention to resolve these prob lems of the prior art and to provide a tissue transfer device which can be well handled, and which is equipped to transport removed tissue over extended distances.
According to the invention a tissue transfer device is proposed in accordance with one or more of the appended claims.
In a first aspect of the invention the tubular struc ture of the tissue transfer device is provided with longitudi nally movable wall sections, and that said wall sections are in dividually back and forth movable in the longitudinal direction of the device, wherein the device is arranged such that during transport of tissue between the distal end and the proximal end, first wall sections assume a repetitious cycle of longitudinally moving in the direction of the proximal end and back, and second wall sections assume a repetitious shifted cycle with reference to the motions of the first wall sections such that while the first wall sections move in the direction of the proximal end and back, the second wall sections longitudinally move in the direction of the distal end and forth, wherein the first wall sections and the second wall sections exert in absolute terms mutually different frictional forces on the tissue. This pro vides the effect that the frictional forces exerted by the first wall sections and the second wall sections in combination result in a net frictional force acting on the tissue pointing in an intended direction towards one of the proximal end and the dis tal end, which will cause the tissue to move in such intended direction .
With the construction of the tissue transfer device of the invention the need to use suction or a grasper is avoided, and the tissue transport is not adversely affected by the slen derness of the construction of the device. The tissue transfer device of the invention can be used on a very broad range of tissue types, including bone and fat tissue. It is even possible to construe the longitudinally movable wall sections of the de vice to make it flexible and capable to follow bends. It is also possible to make the device steerable.
One of the niceties of the invention is that the design of the tissue transfer device is highly versatile, which follows from the many optional embodiments that are feasible as men- tioned hereinafter.
Suitably the wall sections are selected from the group comprising cables, rods, tubes, glassfibres or combinations thereof. Since the group is not limited also other embodiments are feasible.
Also suitably the wall sections are provided with one or more shapes selected from the group comprising round, square, rectangular, or triangular or combinations thereof. Since also this group is not limited other shapes are feasible as well.
In a first preferable embodiment the first and second wall sections have mutually different dimensions to provide that, because of the different dimensions which imply different contact areas with the tissue, these wall sections will exert mutually different frictional forces on the tissue.
In a second preferable embodiment which may be applied in combination with or separate from the first embodiment, at their side facing the lumen the first and second wall sections have mutually different surface properties or claddings or structures to provide that these wall sections exert mutually different frictional forces on the tissue.
In a third preferable embodiment which may be applied in combination with or separate from the first and/or second em bodiment, the first and second wall sections move at mutually different speeds and/or accelerations, which will then affect the frictional forces that will be applied on the tissue by the respective first and second wall sections.
In a fourth preferable embodiment which may be applied in combination with or separate from the first embodiment, or in combination with or separate from the second embodiment, or in combination with or separate from the third embodiment, or in any other suitable permutation of combinations with a selection or with all of said other embodiments, the first wall sections and the second wall sections differ in number.
In the case of the fourth embodiment it is preferred that a preselected first number of wall sections cyclically moves in the direction of the proximal end and back, and a pre selected second number of wall sections longitudinally moves in the direction of the distal end and forth, wherein the first number is higher than the second number in case it is desired that the tissue moves towards the proximal end and lower in case it is desired that the tissue moves towards the distal end.
When the first number of the longitudinally movable wall sections that move in the direction of the proximal end is higher than the second number of the longitudinally movable wall sections that move in the direction of the distal end, this pro vides the effect that the combined frictional forces applying to the tissue to be transported will cause the tissue to move to wards the proximal end. Conversely when the first number of the longitudinally movable wall sections that move in the direction of the proximal end is lower than the second number of the lon gitudinally movable wall sections that move in the direction of the distal end, this provides the effect that the combined fric tional forces applying to the tissue to be transported will cause the tissue to move towards the distal end.
A straightforward and relatively simple sub-embodiment of the fourth embodiment is that when the wall sections are mu tually identical the first number and the second number add up to a total of at least three longitudinally movable wall sec tions .
An advantage of this sub-embodiment of the fourth em bodiment is that it is already possible to provide an effective transfer device by arranging that the first number and the sec ond number of the longitudinally movable wall sections add up to a total of at least three. In a preferable further developed em bodiment the first number is four and the second number is two, so the total number of movable wall sections is then six.
In all embodiments it is preferred, that means that it is not a requirement, that the tubular structure comprises an outer tube wherein the longitudinally movable wall sections are at least in part contained. In this manner interference of the longitudinally movable wall sections with the tissue remaining in the patient's body can be effectively avoided.
The tissue transfer device of the invention is suitably embodied such that the device comprises a motor drive at the proximal end for individually driving the longitudinally movable wall sections. Of course this is only an option (correspondingly it is part of a dependent claim) and the device could well func tion when it would be manually driven as can be noted from the main claim which does not specify how the wall sections are driven . The invention will hereinafter be further elucidated with reference to the drawing of an exemplary embodiment of a tissue transfer device according to the invention that is not limiting as to the appended claims. For the purpose of this ex planation and for reasons of simplicity reference is made to the above-mentioned fourth embodiment.
In the drawing:
-figure 1 shows a perspective view at a tissue transport device according to the invention in an experimental setup;
-figure 2 shows a side view of the tissue transport de vice according to figure 1;
-figure 3 shows a sequence of events in a first embodi ment of the tissue transfer device of figure 1; and
-figure 4 shows a sequence of events in a second embod iment of the tissue transfer device of figure 1.
Whenever in the figures the same reference numerals are applied, these numerals refer to the same parts.
Figure 1 shows an experimental setup of a tissue transport device 1 according to a fourth embodiment of the in vention. This tissue transport device 1 comprises a tubular structure 2 with a lumen 3. The lumen 3 is arranged between a proximal end 5 and a distal end 4 of the device 1 which may be better seen in figure 2. The distal end 4 is during use located in the patient's body for picking up the tissue to be removed.
The device 1 according to this fourth embodiment is de signed to transport tissue from the distal end 4 to the proximal end 5, and for this purpose the tubular structure 2 comprises longitudinally movable wall sections 6. Said wall sections 6 are individually back and forth movable in the longitudinal direc tion of the device 1, such that during transport of tissue from the distal end 4 to the proximal end 5, at any instance during the transport a preselected first number of wall sections longi tudinally moves in the direction of the proximal end 5, and a preselected second number of wall sections 6 stands still or longitudinally moves in the direction of the distal end 4, wherein the first number is higher than the second number. In this manner the frictional forces applying to the tissue to be transported through the lumen 3 cause that the tissue moves in the direction of the proximal end 5. In order to arrange for a continuous movement of the tissue, the longitudinally movable wall sections 6 are back and forth movable or reciprocating in order to entertain indeed a continuous movement of the tissue from the distal end 4 to the proximal end 5 of the device 1.
It is found beneficial that the first number and the second number add up to a total of at least three longitudinally movable wall sections 6. Preferably the first number is four and the second number is two, so that the total number of longitudi nally movable wall sections 6 counts six. This is depicted in figure 1 that shows four wall sections of a first group indicat ed with reference 6' that may act on the tissue to be transport ed by moving towards the distal end 4, whilst in a mode shifted with reference to said first group a second and larger group of wall sections indicated with reference 6' ' that stands still or moves in the direction of the proximal end 5. The resulting force acting on the tissue is that the forces applied by the wall sections 6' ' of the second group will be higher than the forces applied by the wall sections 6' of the first group, which will cause the tissue to move towards the proximal end 5.
A detailed illustration of possible movements of the wall sections 6' of the first group and the wall sections 6' ' of the second group is provided by figure 3, in which each time a single wall section 6' (see f.i. fig. 3b) moves towards the dis tal end 4, and the remaining five wall sections 6'' move in a mutually shifted phase towards the proximal end 5. At the time the wall section 6' ' -h that is closest to the proximal end 5 has reached its farthest position, it stops and changes direction and becomes the next single wall section 6'-c (see fig. 3c) to move towards the distal end 4, whereas the previous wall section 6'-b that moved towards the distal end 4 has stopped and has started to move towards the proximal end 5 as shown in fig. 3c with reference 6''-c. This cycle repeats to give all wall sec tions a turn in acting as the single wall section 6' to move to wards the distal end 4, while the remainder of the wall sections 6'' moves towards the proximal end 5.
Figure 4 shows an alternative embodiment wherein two pairs of wall sections 6' ' move towards the proximal end 5 while one pair of wall sections 6' moves towards the distal end 4. In such a situation, the friction exerted upon the tissue by the wall sections 6' ' is twice as large as the friction exerted by the wall sections 6' . In an effort to reduce the effect of in strument orientation, the wall sections belonging to the same pair oppose each other so that the (small) forces of gravity and the amount of surface contact of the wall sections with irregu larly shaped pieces of transportable tissue affect each pair of wall sections equally.
Figure 1 further clearly shows a preferable arrangement wherein the tubular structure 2 comprises an outer tube 7 where in the longitudinally movable wall sections 6 are at least in part contained.
In figure 2 it is shown that the device 1 preferably comprises a motor drive 8 at the proximal end 5 for individually driving the longitudinally movable wall sections 6.
Although the invention has been discussed in the fore going detailed description with reference to an exemplary fourth embodiment of the tissue transport device of the invention, the invention is not restricted to this particular embodiment which can be varied in many ways without departing from the invention. This discussed exemplary fourth embodiment shall therefore not be used to construe the appended claims strictly in accordance therewith. On the contrary the fourth embodiment is merely in tended to explain the wording of the appended claims without in tent to limit the claims to this exemplary embodiment. The scope of protection of the invention shall therefore be construed in accordance with the appended claims only, wherein a possible am biguity in the wording of the claims shall be resolved using this exemplary embodiment.
As will be clear from the foregoing, other possible em bodiments are not shown in the drawing of figures 1 and 2, yet such other embodiments are also feasible.
Possible other embodiments show one of more of the fol lowing features:
-that the wall sections 6 are selected from the group comprising cables, rods, tubes, glassfibres ;
-that the wall sections 6 are provided with a shape se lected from the group comprising round, square, rectangular, or triangular;
-that the first and second wall sections 6 have mutual ly different dimensions to provide that these wall sections ex ert mutually different frictional forces on the tissue; -that facing the lumen 3 the first and second wall sec tions 6 have mutually different surface properties or claddings or structures to provide that these wall sections exert mutually different frictional forces on the tissue; and
-that the first and second wall sections 6 move during transportation of the tissue at mutually different speeds and/or accelerations .

Claims

1. Tissue transfer device (1) comprising a tubular structure (2) with a lumen (3), wherein the lumen (3) is ar ranged between a proximal end (5) and a distal end (4) of the device (1), and wherein tissue is transportable between the dis tal end (4) and the proximal end (5), characterized in that the tubular structure (2) comprises longitudinally movable wall sec tions (6, 6' , 6' ' ) , and that said wall sections (6, 6' , 6'') are individually back and forth movable in the longitudinal direc tion of the device (1), wherein the device (1) is arranged such that during transport of tissue between the distal end (4) and the proximal end (5), first wall sections (6') assume a repeti tious cycle of longitudinally moving in the direction of the proximal end (5) and back, and second wall sections (6'') assume a repetitious shifted cycle with reference to the motions of the first wall sections (6') such that while the first wall sections (6') move in the direction of the proximal end (5) and back, the second wall sections (6'') longitudinally move in the direction of the distal end (4) and forth, wherein the first wall sections (6') and the second wall sections (6'') exert in absolute terms mutually different frictional forces on the tissue.
2. Tissue transfer device according to claim 1, characterized in that the combination of the frictional forces exerted by the first wall sections (b') and the second wall sections (6'') are arranged to result in a net frictional force acting on the tissue pointing in an intended direction towards one of the proximal end (5) and the distal end (4) .
3. Tissue transfer device according to claim 1 or 2, characterized in that the wall sections (6) are selected from the group comprising cables, rods, tubes, glassfibres.
4. Tissue transfer device according to any one of claims 1 - 3, characterized in that the wall sections (6) are provided with a shape selected from the group comprising round, square, rectangular, or triangular.
5. Tissue transfer device according to any one of claims 1 - 4, characterized in that the first and second wall sections (6) have mutually different dimensions to provide that these wall sections exert mutually different frictional forces on the tissue.
6. Tissue transfer device according to any one of claims 1 - 5, characterized in that facing the lumen (3) the first and second wall sections (6) have mutually different sur face properties or claddings or structures to provide that these wall sections exert mutually different frictional forces on the tissue .
7. Tissue transfer device according to any one of claims 1 - 6, characterized in that the first and second wall sections (6) move at mutually different speeds and/or accelera tions .
8. Tissue transfer device according to any one of claims 1 - 7, characterized in that the first wall sections and the second wall sections differ in number.
9. Tissue transfer device according to claim 8, characterized in that a preselected first number of wall sections (6') cyclically moves in the direction of the proximal end (5) and back, and a preselected second number of wall sections (6' ' ) longitudinally moves in the direction of the distal end (4) and forth, wherein the first number is higher than the second number in case it is desired that the tissue moves towards the proximal end and lower in case it is desired that the tissue moves to wards the distal end.
10. Tissue transfer device according to claim 9, characterized in that when the wall sections are mutually identical the first number and the second number add up to a total of at least three longitudinally movable wall sections (6) .
11. Tissue transfer device according to claim 9 or 10, characterized in that the first number is four and the second number is two.
12. Tissue transfer device according to any one of claims 1 - 11, characterized in that the tubular structure (2) comprises an outer tube (7) wherein the longitudinally movable wall sections (6) are at least in part contained.
13. Tissue transfer device according to any one of claims 1 - 12, characterized in that the device (1) comprises a motor drive (8) at the proximal end (5) for individually driving the longitudinally movable wall sections (6) .
PCT/NL2019/050608 2018-09-18 2019-09-17 Tissue transfer device WO2020060397A1 (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080249553A1 (en) * 2007-04-06 2008-10-09 William Harwick Gruber Method, system and device for tissue removal
US20100331883A1 (en) 2004-10-15 2010-12-30 Schmitz Gregory P Access and tissue modification systems and methods
US20150223787A1 (en) 2005-08-10 2015-08-13 C.R. Bard, Inc. Single-insertion, multiple sampling biopsy device usable with various transport systems and integrated markers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100331883A1 (en) 2004-10-15 2010-12-30 Schmitz Gregory P Access and tissue modification systems and methods
US20150223787A1 (en) 2005-08-10 2015-08-13 C.R. Bard, Inc. Single-insertion, multiple sampling biopsy device usable with various transport systems and integrated markers
US20080249553A1 (en) * 2007-04-06 2008-10-09 William Harwick Gruber Method, system and device for tissue removal

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