WO2020040584A1

WO2020040584A1 - Molecule sensor and cancer diagnostic system using same

Info

Publication number: WO2020040584A1
Application number: PCT/KR2019/010737
Authority: WO
Inventors: 권민상; 권위상; 카사마야스히코; 이명관; 인기욱; 박남현; 강우신
Original assignee: 권민상; 권위상
Priority date: 2018-08-23
Filing date: 2019-08-23
Publication date: 2020-02-27

Abstract

The present invention pertains to a molecule sensor capable of accurately detecting, at a molecular level, a substance to be detected using energy levels of oxidation-reduction potential. Particularly, the energy levels of oxidation-reduction potential of a substance to be detected are analyzed, and, with the electrons provided by the substance to be detected as the medium, energy levels of the negative electrode substance and positive electrode substance are configured so that, when the substance to be detected is introduced, the electrons are transferred from the negative electrode to positive electrode.

Description

Molecular sensor and cancer diagnosis system using this molecular sensor

The present invention relates to a molecular sensor that detects the presence, type, and amount of a substance to be detected in units of molecules, and in particular, is proportional to the number of molecules of the substance to be detected (hereinafter referred to as "detectable substance"). By designing the energy levels of the cathode and anode in consideration of the energy level of the redox potential of the target material so that a large number of electrons can move from the cathode to the anode, it is possible to precisely detect the target material on a molecular basis.

In addition, the method further includes a substance (hereinafter, referred to as a "mobile inducing substance") that assists and induces electron movement from the cathode to the anode according to the type of the detection target material to be detected, and the electrons in the valence band are conducted as conduction bands. By further comprising an excitation energy supply unit for supplying excitation energy to excite (excited atoms), more precise detection can be made.

In addition, using a dye, fullerene, fullerene salt, or fullerene containing ions (hereinafter referred to as “ion-containing fullerene”) as a mobile inducer, the redox potential is lowered and quantum yield is obtained. Increasing) increases the range of the detectable substance and improves the measurement sensitivity.

In addition, the present invention is to use the molecular sensor described above to detect cancer, early detection of cancer, to prolong life and to pursue a healthy life.

Efforts to detect whether a particular substance is present have accelerated with the development of industrial technology, resulting in the development of many types of sensors that use different principles in different industries. These sensors have quickly replaced the five senses of human beings in all fields of industry such as electricity, electronics, machinery, chemistry, physics, biotechnology, medicine, etc. have.

As the technology is further developed, the development of ultra-precision sensors capable of detecting trace amounts of materials is continuously used, which is used in the fields of ultra-precision diagnostic medicine, ultra-precision sensing, ultra-precision control, and bio and space science.

1) cantilever type precision sensor for detecting a substance to be detected by detecting mechanical distortion caused by adsorption of the substance to be detected;

2) a precision sensor of a semiconductor sensor type for detecting a substance to be detected by detecting a change in resistance according to adsorption of the substance to be detected;

3) A precision sensor using an asymmetric field ion transport analysis method that detects a substance to be detected by passing a substance to be detected inside a fluctuating electric field so that only molecules having a specific mass area ratio reach the detector;

4) An accurate sensor using a gene sensing method that detects a substance to be detected using a genetically modified mouse receptor is an example of such an ultra precision sensor.

However, in ~ ppb (. Parts per billion 1/10 -9) conventional techniques is that the detection accuracy ^{ppm (parts per million, 1/10 -6} ) level as described above, ppt (parts per trillion, 1/10 - ¹² ) There were problems such as accurate measurement reaching the level and ultra-precision measurement in molecular units.

An object of the present invention is to solve the conventional problems as described above, in particular, by using the energy level of the redox potential to detect the target material in molecular units of a new concept that can accurately detect the ppt level To provide a "molecular sensor".

In addition, it is to provide a "molecular sensor" capable of real-time detection by detecting a current through the electrons donated from the detection target material.

In addition, the detection target material is detected by using a mobile induction material (anode-side movement induction material, cathode-side movement induction material) having energy levels of various redox potentials, thereby widening the detection object and making more accurate detection. will be.

The present invention is a molecular sensor capable of precisely detecting a target substance on a molecular basis by using the energy level of the redox potential, in particular, by analyzing the energy level of the redox potential of the substance to be detected, In this case, the energy levels of the negative electrode material and the positive electrode material are designed and configured such that electrons are transferred from the negative electrode to the positive electrode through the electrons donated by the detection target material.

In addition, the energy level is designed using one or more moving inducing materials that induce electron transfer from the cathode to the anode, and the lumo of the conduction band in the Highest Occupied Molecular Orbital (HOMO). (LUMO: Lowest Unoccupied Molecular Orbital) provides excitation energy (light energy, heat energy, etc.) to control the movement of the electrons to excite the electrons, characterized in that it is configured to make more accurate detection.

In addition, it is characterized by extending the detection range and improving the measurement sensitivity by constituting the mobile inducer with at least one of fullerene, fullerene salt, ion-containing fullerene, pigment, or complex of ion-containing fullerene and pigment.

The fullerene is any one of C60, C70, C72, C78, C82, C90, C94, C96, and the ions contained in the iontofullerene are lithium, sodium, potassium, cesium, magnesium, calcium, Or strontium, and the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT , P3OT, POPT, MDMO-PPV, MEH-PPV and the like, characterized in that at least one of a polymer or a derivative thereof.

In particular, the "molecular sensor" of the present invention has the effect of accurately detecting the molecular units at the ppt level by detecting the detection target substance using the energy level of the redox potential.

In addition, by designing the energy level using a mobile induction material, it is effective to widen the detection range, increase selectivity, and increase accuracy.

In addition, the energy level of the redox potential is very low and the quantum yield is high by using ion-containing fullerenes and pigments to design the energy level, thereby further extending the detection range and accuracy.

The present invention provides a ppt level of precision detection technology to solve the detection problems that could not be solved by the existing technologies in the field of ultra-precision diagnostic medicine, ultra-precision sensing, ultra-precision control and bio, aerospace sciences to make a leap forward in the field. It is effective to tow.

For example, it can be configured to detect early cancers (substances caused by cancer) present in trace amounts in the breath, urine, blood and saliva, and to diagnose early cancer, Can be configured to detect tuberculosis early, to detect the bad breath (materials caused by bad breath) to determine the cause of bad breath, stress caused substances It is effective in detecting the stress level by detecting (substances caused by stress). In addition, it can be configured to detect a small amount of deadly poison gas such as sarin gas, dioxin and the like to pre-alarm, as well as to configure a variety of precision sensors in various fields.

1 is a view showing the energy level design of the "molecular sensor" of the present invention,

2 is a view showing another energy level design of the "molecular sensor" of the present invention;

3 is a view showing another energy level design of the "molecular sensor" of the present invention;

4 is a view showing another energy level design of the "molecular sensor" of the present invention;

5 is a view showing another energy level design of the "molecular sensor" of the present invention;

6 is a view showing another energy level design of the "molecular sensor" of the present invention;

7 is a view showing another energy level design of the "molecular sensor" of the present invention;

8 is a view showing another energy level design of the "molecular sensor" of the present invention;

9 is a view showing another energy level design of the "molecular sensor" of the present invention;

10 is a view showing another energy level design of the "molecular sensor" of the present invention;

11 is a view showing another energy level design of the invention "molecular sensor",

12 is a view showing another energy level design of the present invention "molecular sensor",

13 is a view showing another energy level design of the "molecular sensor" of the present invention;

14 is a view showing another energy level design of the invention "molecular sensor",

15 is a block diagram showing a system configuration of the present invention;

16 is a view showing the configuration of the sensor electrode unit of the present invention;

17 is a view showing an energy level design according to an embodiment of the present invention;

18 is a view showing a configuration of a sensor electrode unit according to an embodiment of the present invention;

19 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention;

20 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention;

21A is a conceptual diagram showing an ion containing fullerene,

Fig. 21B is a conceptual diagram showing the structure of a polymer in which an iontophorfullerene and a dye are bonded;

21C is a conceptual diagram showing an excited state of electrons by light energy;

22 is a conceptual diagram showing the electrophoresis of fullerene-pigment polymer on the positive electrode,

Fig. 23 shows the energy level of electrons.

24 is a diagram conceptually showing a circuit configuration of a potentiostat;

25 is a diagram showing an example of a configuration of a measuring electrode;

26 is a graph illustrating interval enlargement of a CV graph;

27 is a graph showing an example of quantum yield according to wavelength.

29 and 28 are views for explaining a second embodiment of the present invention;

30 to 32 are views for explaining a third embodiment of the present invention;

33 to 38 are views for explaining a fourth embodiment of the present invention;

39 and 40 are views for explaining a fifth embodiment of the present invention;

41 to 45 are views for explaining a sixth embodiment of the present invention;

46 is a view for explaining a seventh embodiment of the present invention;

47 and 48 are views for explaining an eighth embodiment of the present invention;

49 is a view for explaining a ninth embodiment of the present invention;

Hereinafter, an embodiment of the present invention will be described.

[First Embodiment]

The first embodiment of the present invention relates to a molecular sensor and can detect cancer or other molecules such as explosives using the energy of the molecular sensor. Preferably, the present invention is based on cancer detection, and the following configurations 1 to 7 and other configurations are utilized for designing the energy level of the sensor electrode of the cancer diagnostic sensor.

Configuration 1 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 1, the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected; And an anode configured to have a redox potential lower than the energy level of the valence band of the detection target material. When the detection target material is introduced between the cathode and the anode, The technical configuration is characterized by the fact that the energy level is set to allow electron movement to the anode.

In the configuration 1 of the present invention configured as described above, the energy level of the cathode is designed to be higher than that of the detection target material, and the energy level of the anode is designed to be lower than that of the detection target material. The electrons can be moved to the anode.

The relationship between the energy level c of the valence band of the positive electrode, the energy level e of the valence band of the detection target material, and the energy level a of the valence band of the negative electrode is as follows.

Energy level of configuration 1: c <e, e <a

In the configuration 1 of the present invention, when a detection material having an energy level between the energy level value of the cathode and the energy level value of the anode is introduced, electrons in the valence band of the detection material have a lower energy level than their own. The electrons move from the cathode to the hole of the valence band of the detection target material caused by the electrons moved to the anode, and the number of electrons proportional to the detection target material is maintained as long as the detection target material exists. Will be moved to.

At this time, it is possible to determine whether the detection target material exists by detecting the movement of electrons (whether the current flows), and precisely determine the amount of the detection target material introduced by detecting the degree of movement of electrons (amount of current). have.

Since the movement of electrons is proportional to the number of molecules of the incoming detection target material, very precise detection of the molecular units can be performed by detecting the movement (current amount) of the moving electrons.

The selectivity for the substance to be detected increases as the energy level difference between the cathode and the anode becomes smaller.

The technique according to the configuration 1 of the present invention is preferably used when detecting a substance having a radical in a natural state such as nitrogen oxides (NOx) or hydrogen peroxide.

Configuration 2 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 2, the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential lower than the energy level of the conduction band of the detection target material; And an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the detection target material can be excited with a conduction band, when the detection target material is introduced between the cathode and the anode. The excitation energy supplied from the supply unit excites the electrons in the valence band of the target material into the conduction band, the electrons excited in the conduction band move to the anode, and are holes in the valence band of the material to be detected. It is characterized by the technical configuration that the energy level is set so that the process of moving is accomplished.

Energy levels in composition 2: c> e, e <a

In the configuration 2 of the present invention configured as described above, excitation energy (for example, light) larger than the band gap energy of the valence band and conduction band of the detection target material is supplied to the detection target material to provide the valence band of the detection target material. The electrons in the band are excited by the conduction band, and the electrons excited in the band are transferred to the anode having an energy level lower than the energy level of the band. In addition, the electrons are moved from the cathode to the positive holes generated in the valence band of the detection target material, and the current is proportional to the number of molecules of the detection target material by repeating the above process as long as the excitation energy is supplied. Is to flow.

According to the configuration 2 of the present invention, when the energy level of the anode is higher than the energy level of the valence band of the detection target material, the electrons in the valence band of the detection target material cannot move to the anode. It is excited to conduct the excited electrons to the anode by using the energy level of the excited electrons.

This will be described as follows.

As is well known, as shown in Fig. 22, a band filled with electrons is called a valence band, and its highest trajectory is called a HOMO. In addition, the band in which the electron is empty is called a conduction band, the lowest orbit is called LUMO, and the energy between the homo and lumo is called bandgap energy (Eg). When supplied, the electrons in the valence band can be excited by a conduction band.

As shown in FIG. 2, the configuration 2 of the present invention supplies energy above the bandgap energy through an excitation energy supply unit to excite electrons in the valence band of the detection target to a conduction band to raise the energy level to the anode. Is to make the electron transfer.

The excitation energy supply unit is characterized in that it is composed of any one or more of an optical energy supply unit, an electromagnetic wave energy supply unit, or a thermal energy supply unit for supplying energy above the band gap energy between the valence band and the conduction band.

The excitation energy supply unit configures excitation energy using light energy, electromagnetic wave energy, or thermal energy, and in some cases, excitation energy may be configured by using two or more energy sources together. For example, it may be configured to supply a predetermined amount of excitation energy with light energy and to supply a predetermined amount of excitation energy with thermal energy. This configuration is intended to be used when one energy source cannot supply excitation energy of the desired size.

In the description, the term "electromagnetic wave" includes both heat and light, but is used for convenience of description.

The light irradiated by the optical energy supply unit is characterized by consisting of one or more lights having different wavelengths and brightness.

The light source irradiated by the light energy supply unit is characterized in that the LED light source having a different wavelength, or a laser light source having a different wavelength, a halogen lamp, a mercury lamp, or any one of xenon lamp.

Such an optical energy supply unit is for supplying different bandgap energy by designing an amount of excitation energy by wavelength or brightness.

For example, when a plurality of anode-side induction materials or cathode-side movement induction materials are used, and the bandgap energy of the used mobile induction materials is different, and each bandgap energy needs to be supplied separately, This can be achieved by adjusting the wavelength or brightness of the light to be supplied.

At this time, the band gap energy can be supplied to all the mobile induction materials by using one light separately. That is, it can be configured to supply excitation energy to a plurality of moving induction materials by using one light source that supplies energy above the largest bandgap energy.

Since the configuration and operation of the driving device for driving the different light sources are well known, detailed description thereof will be omitted.

The electromagnetic wave supplied from the electromagnetic wave energy supply unit is characterized by consisting of one or more electromagnetic waves having different wavelengths and intensities.

The electromagnetic wave energy supply unit is for supplying different bandgap energy by designing the amount of excitation energy by wavelength or intensity. For example, electromagnetic waves such as 1.0 GHz, 1.2 GHz, and 2 GHz may be used.

Since the configuration and operation of the electromagnetic wave generating device for supplying the different electromagnetic waves are well known, detailed description thereof will be omitted.

The heat irradiated by the heat energy supply unit is characterized by consisting of one or more heat having different temperatures and intensities.

The thermal energy supply unit is designed to supply different bandgap energy by designing an amount of excitation energy by temperature and intensity. For example, it can be comprised so that heat, such as 1,000 degreeC heat and 1,500 degreeC heat, may be supplied.

Since the configuration and operation of the heat generating device for generating heat are well known, detailed description thereof will be omitted.

In this configuration 2, the anode or cathode is preferably made of a transparent electrode. Such a transparent electrode is intended to allow light emitted from the excitation energy supply to be transmitted through the detection target material. The transparent electrode is transparent conducting oxide (TCO), F-doped [SnO₂] fluorine-doped tin oxide, Transparent electrodes such as ITO (Indium tin oxide), AZO (Al-doped ZnO: aluminum doped zinc oxide), GZO (Ga-doped ZnO: galvanized doped zinc oxide) may be used.

Configuration 3 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 3, the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; The anode side is configured such that the energy level of the redox potential of the valence band is lower than that of the valence band of the substance to be detected, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Mobile derivatives; And an excitation energy supply unit for supplying excitation energy to excite electrons in the valence band of the anode-side movement inducing material to a conduction band, when the detection target material is introduced between the cathode and the anode. Electrons in the valence band of the anode-side induction material are excited as conduction bands by the excitation energy supplied from an excitation energy supply unit, electrons excited in the conduction band of the cathode-side transport induction material are moved to the anode, and the anode-side movement is performed. The technical configuration is characterized in that the energy level is set so that the electrons of the detection target material move to the holes generated in the valence band of the inductive material, and the electrons move from the cathode to the holes generated in the valence band of the detection target material. do.

Energy levels in composition 3: c> e> g, e <a

Configuration 3 of the present invention configured as described above is characterized in that an electron transfer path is designed by further configuring an anode-side movement inducing material between the detection target material and the anode.

In other words, an electron transport path is designed through the electron donated from the detection target material by further configuring an anode-side movement induction material having an energy level lower than the energy level of the valence band of the detection target material.

The anode-side movement inducing material or the cathode-side movement inducing material is characterized in that it is composed of any one or more of a fullerene, a fullerene salt, ion-containing fullerenes, pigments, or polymers of ion-containing fullerenes and pigments.

The fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, C96.

The ion contained in the fullerene is any one of lithium, sodium, potassium, cesium, magnesium, calcium, or strontium.

The pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, MDMO-PPV, MEH-PPV It is characterized by one or more of a high molecular polymer or derivatives thereof.

FIG. 20A shows the inclusion of ions in C60 fullerene, FIG. 20B shows the binding of ionic inclusion fullerene and a pigment, and 20c is a conceptual diagram showing excitation of electrons by light energy.

Lithium-included fullerene has an advantage that the energy level of the redox potential of the valence band is very low, thereby broadening the range of a target to be detected.

In addition, lithium-encapsulated fullerene has a high quantum yield (IPCE: Incident Photon to Current Efficiency) has the advantage of improving the measurement sensitivity.

The quantum yield indicates the ratio of the number of molecules and the number of photons absorbed, which actually caused a chemical change in the photochemical reaction.

The anode-side movement inducing material, or cathode-side movement inducing material is characterized in that it is included in the positive electrode, or the negative electrode by using electrophoresis (electrophoresis).

FIG. 21 is a diagram showing the electrophoresis of the fullerene-pigment polymer 122a on the positive electrode 121a.

The anode-side movement inducing material or cathode-side movement inducing material may be a material having energy levels of various redox potentials, such as [TiO₂], [SnO₂], by using such a mobile induction material more precise and accurate energy level Can be designed.

Configuration 4 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 4, the negative electrode configured to have a redox potential higher than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; Anode-side shifting where the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Inducer; And excitation energy for supplying excitation energy to excite the electrons in the valence band of the anode-side moving induction material to the conduction band, and excitation energy for supplying excitation energy for electrons in the valence band of the detection target material to the conduction band. When the detection target material is introduced between the cathode and the anode, first, the electrons in the valence band of the anode-side moving induction material by the excitation energy supplied from the excitation energy supply unit Electrons excited by the conduction band of the anode-side moving inducing material move to the anode, and second, electrons in the valence band of the detection target material are excited by the excitation energy supplied from the excitation energy supply unit, Electrons excited by the conduction band of the detection target material are holes generated in the valence band of the anode-side transfer inducing material. And, third, an energy level is set so that a process of moving electrons from the cathode to the holes formed in the valence band of the detection target material is made.

Energy levels in Configuration 4: c> g> e, e <a

In the configuration 4 of the present invention configured as described above, in designing the electron migration path according to the inflow of the detection target material, the molecular sensor is configured by exciting the electrons in the valence band of the detection target material and the anode-side movement induction material with a conduction band. There is a characteristic.

Configuration 5 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 5, the negative electrode configured to have a redox potential lower than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential lower than the energy level of the valence band of the detection target material; The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And an excitation energy supply unit for supplying excitation energy to excite the electrons in the valence band of the cathode-side movement inducing material to the conduction band, when the detection target material is introduced between the cathode and the anode. And electrons in the detection target material move to the anode, and second, electrons in the valence band of the cathode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the cathode-side moving induction material Electron excited by the conduction of the electrons moved to the hole formed in the valence band of the target material, and third, the energy level is set so that the process of electrons move from the cathode to the hole formed in the valence band of the cathode-side moving induction material The technical configuration features.

Energy level in Configuration 5: c <e, e> a> i

The configuration 5 of the present invention configured as described above is characterized in that when the energy level of the detection target material is higher than that of the cathode, smooth electron transfer can be performed by the cathode-side movement inducing substance.

According to the technical idea of the "molecular sensor" of the present invention, the configuration 6, as shown in Figure 6, the negative electrode configured to have a redox potential lower than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential lower than the energy level of the conduction band of the detection target material; The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And excitation energy for supplying excitation energy to excite the electrons in the valence band of the cathode-side moving induction material to the conduction band, and excitation energy for supplying excitation energy for electrons in the valence band of the detection target material to the conduction band. When the detection target material is introduced between the cathode and the anode, first, the electrons in the valence band of the detection target material is excited by the excitation energy supplied from the excitation energy supply unit, Electrons excited by the conduction band of the detection target material move to the anode, and second, electrons in the valence band of the cathode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the cathode side The electrons excited by the conduction band of the mobile induction material move to the hole formed in the valence band of the detection target material. Second, and that the process of the electron transfer from the cathode to the electron hole occurs in the valence band of the cathode-side movement inducer done so that the energy level is set, characterized in that on the technical configuration.

Energy levels in Configuration 6: c> e, e> a> i

In the structure 6 of the present invention configured as described above, in designing an electron migration path according to the inflow of the detection target material, the molecular sensor is configured by exciting the electrons in the valence band of the detection target material and the cathode-side moving induction material with a conduction band. There is a characteristic.

According to the technical idea of the "molecular sensor" of the present invention, a configuration 7 includes: a cathode configured to have a redox potential lower than the energy level of the valence band of a detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; The anode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the substance to be detected, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the redox level of the anode. Mobile derivatives; The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And supplying excitation energy so that electrons in the valence band of the anode-side mobile induction material can be excited with a conduction band, and supplying excitation energy so that electrons in the valence band of the cathode-side moving inductive material can be excited with a conduction band. When the detection target material is introduced between the cathode and the anode, first, the electrons in the valence band of the positive electrode-side moving induction material by the excitation energy supplied from the excitation energy supply unit Electrons excited by the conduction band and excited by the conduction band of the anode-side transport inducing material move to the anode, and second, electrons of the detection target material move to the holes generated in the valence band of the anode-side transport inducing material. The electrons in the valence band of the cathode-side mobile induction material are excited by the excitation energy supplied from the excitation energy supply unit. Electrons excited by the conduction band of the cathode-side movement inducing material move to holes formed in the valence band of the detection target material, and fourth, holes generated in the valence band of the cathode-side movement inducing material are electrons in the cathode. The technical configuration is characterized by the fact that the energy level is set so that the process of movement takes place.

Energy level of composition 7: c> e> g, e> a> i

Configuration 7 of the present invention configured as described above is characterized by configuring the molecular sensor by designing the electron transfer path according to the inflow of the detection target material using the anode-side induction material and the cathode-side movement induction material.

Configuration 8 according to the technical idea of the "molecular sensor" of the present invention, as shown in Figure 8, the negative electrode configured to have a redox potential lower than the energy level of the valence band of the detection target material to be detected; An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material; Anode-side shifting where the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Inducer; The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And supplying excitation energy so that the electrons in the valence band of the anode-side mobile induction material can be excited with a conduction band, and supplying excitation energy so that electrons in the valence band of the cathode-side moving inductive material can be excited with a conduction band. And an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the detection target material can be excited with a conduction band. When the detection target material is introduced between the cathode and the anode, first, the The electrons in the valence band of the anode-side induction material are excited to the conduction band by the excitation energy supplied from the excitation energy supply unit, and the electrons excited in the conduction band of the cathode-side transport induction material are moved to the anode, and second, the excitation Excitation energy supplied from the energy supply unit causes electrons in the valence band of the detection target to The electrons excited by the conduction band of the detection target material move to the positive holes generated in the valence band of the anode-side moving induction material, and third, the home appliance of the cathode-side moving induction material is excited by the excitation energy supplied from the excitation energy supply unit. The electrons in the magnetic field are excited by the conduction band, the electrons excited by the conduction band of the cathode-side transport inducing material move to the hole formed in the valence band of the detection target material, and fourth, the electrons generated in the valence band of the cathode-side transport inducing material It is characterized by the technical configuration that the energy level is set so that the process of electrons move from the cathode to the positive hole.

Energy level of configuration 8: c> g> e, e> a> i

In the configuration 8 of the present invention configured as described above, in designing the electron transfer path according to the inflow of the detection target material using the anode-side induction material and the cathode-side movement induction material, the anode-side movement induction material and the cathode-side movement induction material And constituting a molecular sensor by exciting the detection target material.

In the above configurations, the anode-side movement inducing material for inducing the movement of the donated electrons to the anode is characterized in that it is composed of one or more.

In the above configurations, when a plurality of anode-side movement inducing substances are formed, as shown in FIGS. 9 to 10 and 13 to 14, the first anode-side movement induction for receiving electrons from the detection target material is shown. The energy level of the conduction band of the material is set to be higher than the energy level of the valence band of the next anode-side inductive material, and the energy level of the conduction band of the anode-side mobile inductive material that contributes electrons to the anode is the energy level of the anode. The energy level of the anode-side mobile induction material in the intermediate stage is set higher than the energy level of the valence band of the anode-side mobile inductive material in the next stage. It is characterized by setting the level below the energy level of the conduction band of the anode-side mobile induction material in the previous stage.

Such a configuration enables the detection of a detection target material by using a plurality of anode-side moving induction materials, and enables a more accurate energy level design for the detection target material.

In the above configurations, the cathode-side movement inducing material for inducing the movement of the electrons donated from the cathode to the detection target material is characterized in that it is composed of one or more.

In the above configuration, in the case where a plurality of cathode-side movement inducing substances are formed, as shown in Figs. 11 to 14, the energy level of the conduction band of the first cathode-side movement inducing substance that receives electrons from the cathode is The energy level of the conduction band of the cathode-side moving inductive material which is higher than the energy level of the valence band of the cathode-side moving induction material and donates electrons to the holes generated in the valence band of the detection material is determined by The energy level of the cathode-side mobile induction materials in the middle stage is set higher than the energy level of the valence band, and the energy level of the conduction band is set higher than that of the valence band of the cathode-side mobile induction material in the next stage. In other words, the energy level of the valence band is set lower than that of the conduction band of the cathode-side mobile inductive material in the previous stage. It shall be.

This configuration allows the detection of the detection target material by using a plurality of cathode-side moving induction materials, which allows for more accurate energy level design for the detection target material.

In the above configuration, as shown in Figure 15, the detection unit 110 for detecting the flow of electrons according to the detection target material: characterized in that it further comprises a.

The detection unit 110 detects the flow of electrons moving from the cathode to the anode and calculates the amount, as well as whether or not the substance to be detected is present. That is, the current and the voltage between the positive electrode and the negative electrode are detected to detect whether or not the detection target material flows in and its amount.

The detection unit detects one or more of Cyclic Voltammetry (CV), Chrono Amperometry (CA), Chrono Potentiommetry (CP), Stripping Voltammetry (SV), or Linear Sweep Voltammetry (LSV) of a target substance. Detecting the presence and amount of the substance.

That is, the presence or the amount of the detection target material is detected by measuring the CV, or CA, or CP, or SV, or LSV of the detection target material using a potentiostat. do.

FIG. 23 is a circuit diagram showing a simplified configuration of a potentiostat. The detection target material is detected through a working electrode (W), a reference electrode (RE), and a counter electrode (CE). can do. That is, after constructing the working electrode (W) using a moving induction material (anode-side moving induction material, cathode side moving induction material), after obtaining the CV, CA, CP, SV, LSV, etc. By analyzing this, it is possible to precisely determine the presence and amount of the detection target material.

Since the structure and operation principle of the potentiostat used in the electrochemical field, the three-electrode method, the two-electrode method, CV, CA, CP, SV, LSV, etc. are well known, the detailed description thereof is omitted.

The detection unit is characterized by detecting the presence and amount of the detection target material by detecting the quantum yield (IPCE: Incident Photon to Current Efficiency) according to the wavelength of the light source supplied to the excitation energy.

FIG. 26 shows the quantum yield (IPCE) according to the wavelength of the light source. As shown in the figure, the quantum yield according to the wavelength varies depending on the material. Therefore, it is possible to know the presence or absence of the detection target material by using the characteristics of the quantum yield curvature. For example, the quantum yield graph of Fig. 26A has a maximum at about 440 nm, a second peak value at 560 nm, and a third order peak value at 620 nm, and this characteristic (peak value, wavelength, slope, peak interval, etc.). ) Can be determined whether or not the substance to be detected.

Since the quantum yield measurement is well known, its detailed description is omitted.

In the above configuration, the display unit 160 for displaying information on the detection target material; characterized in that it further comprises a configuration.

The display unit 160 preferably includes a visual display unit 161 that visually displays information on the flow of electrons according to the detection of a detection target material, and an auditory display unit 162 that is acoustically displayed.

In the above configuration, the communication unit 170 for transmitting information on the detection of the detection target material to the outside; further comprises.

The communication unit 170, the wired communication unit 171 for transmitting information on the detection of the detection target material to a wired line (dedicated line, dedicated network, Internet, etc.), and the information on the detection of the detection target material wireless (wireless communication, mobile communication, Short-range wireless communication, Wi-Fi, Bluetooth, etc.) is preferably composed of a wireless communication unit 172 for transmitting.

In the above configuration, the data storage unit 140 for storing information on the detection of the detection target material; further comprises.

In the drawing, reference numeral 150 denotes a controller, and 180 denotes a power supply unit for supplying operating power to each component.

Hereinafter, the technical idea of the "molecular sensor" of the present invention will be described in detail with reference to Examples.

In the description, the same or similar names and symbols are used for components having the same or similar configurations and functions.

In this embodiment, an FTO (F-doped [SnO₂]) transparent electrode is used as the anode, platinum (Pt) is used as the cathode, and titanium dioxide (TiO₂) and lithium are used as the anode-side inductive materials. containing-fullerene hexafluorotitanate phosphate salt ^- one in toluene ^{([Li + @ C60] [} PF6]) to the (material arising as a cause of cancer) configure the sensor electrode unit, and the memorization of material through the sensor electrode used ( Toluene) will be described as an example.

Therefore, the present embodiment will be described by further comprising an excitation energy supply unit for supplying excitation energy to the anode-side movement inducing material. In the present embodiment, the excitation energy supply unit will be described with an example of supplying light energy.

In the present embodiment, the detection unit for detecting the flow of electrons from the cathode to the anode when the detection material (toluene) is introduced into the sensor electrode portion, and the detection information (detection process, detection conditions, detection results, etc.) A display unit for displaying, a data storage unit for storing the same, and a communication unit for exchanging information on the detection with an external device will be described as an example.

In the present embodiment, the detection of toluene contained in air (exhalation) will be described as an example. Therefore, the sensor electrode unit will be described with an example in which a structure in which air flows between the cathode and the anode is configured. Air (exhalation) containing the detection target material is supplied to the sensor electrode unit using a pumping device.

The reason why the present embodiment is configured as described above is that other configurations and embodiments according to the technical idea of the present invention can be easily understood from the present embodiment.

Hereinafter, the configuration of the present embodiment as described above with reference to the accompanying drawings in detail as follows.

1) Energy level design

An energy level design process of this embodiment for detecting toluene will be described with reference to FIG. 17 as follows.

The energy level based on the vacuum of the valence band of toluene, the substance to be detected, is -6.55 eV, and the energy level of the conduction band is -0.18 eV. Therefore, the energy level of the cathode requires an electrode having an energy level higher than -6.55 eV, which is the energy level of the valence band of the toluene. In this embodiment, platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode. Therefore, when toluene, which is a detection target material, contacts the cathode made of platinum (Pt), it has an energy level structure in which electrons can move from the cathode as holes generated in the valence band of toluene, which is a detection target, due to the difference in energy levels.

In the present embodiment, toluene, which is a detection target material to be detected, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inductive material having a lower energy level is required. In this embodiment, [Li ⁺ @ C60] [PF6 ⁻ ] having an energy level of -7.70 eV in the valence band is used as the anode-side first moving inducer. The energy level of the valence band of [Li ⁺ @ C60] [PF6 ⁻ ] used as the anode-side first moving inducer is lower than the energy level of the valence band of toluene as the detection target material at −6.55 eV. the electrons that ^{[Li + @ C60] [PF6} -] will have the energy level structure that can move electron hole generated in the valence band.

Since the energy level of the conduction band of [Li ⁺ @ C60] [PF6 ⁻ ], which is the anode-side first moving inducer, is -4.90 eV, and the energy level of the valence band of FTO used as the anode is -4.85 eV, the [Li ⁺ @ C60] [PF6 ^-] the electrons in the conduction band can not move directly to the anode of. Therefore, a positive electrode-side second moving material is required.

An anode cheukje first mobile inducers ^{[Li + @ C60] [PF6} -] Since the energy level of the conduction band is -4.90eV, the energy level of the valence band of the positive electrode FTO is -4.85eV, anode cheukje second mobile inducer of the - There is a need for a valence band with an energy level lower than 4.90 eV and a conduction band with an energy level higher than -4.85 eV.

Titanium dioxide (TiO₂) has -6.21eV energy level in valence band and -3.21eV energy level in conduction band. do. Then, the electron excited in the conduction band of [TiO₂] has an energy level structure that can move to the anode.

That is, when the conditions are satisfied, the electrons excited in the electron band of [TiO₂], which is the anode-side second mobile induction material, move to the anode, and the positive holes in the valence band of [TiO₂] are [ Li ⁺ @ C60] [PF6 ^-] move the electrons excited to the conduction band, and wherein [Li ⁺ @ C60] [PF6 of ^-] e of toluene target substance with electron hole generated in the valence band movement, and the toluene Holes in the valence band of the electrons have a moving energy level in the platinum (Pt) cathode.

The positive electrode cheukje first mobile inducer of ^{[Li + @ C60] [PF6} -] Here, the excitation of the light source need 2.8eV or more power with a wavelength of 457nm, and the [TiO₂] cheukje anode 2 move inducer has a 413nm A power of 3.0 eV or more with a light source having a wavelength is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions. For example, a halogen lamp that meets the above conditions can be used.

FIG. 17 illustrates the energy level and the corresponding material designed through the above process, and as shown in the drawing, when toluene as the detection target material is introduced, electrons are moved from the cathode to the anode through two excitation processes according to the energy level. It is designed to move.

2) Sensor electrode part composition

As shown in FIG. 18, the cathode 121 and the cathode 124 are mounted inside the case 125, and operation power is supplied to the anode 121 and the cathode 124 through the power supply unit 180. In addition, the sensor 110 is connected to the detector 110 so as to detect a current flowing between the anode 121 and the cathode 124.

The case 125 is formed of a transparent material (eg, glass, quartz, etc.) on the surface on which the anode 121, which is a transparent electrode, is mounted, and light supplied from the light source 131, which is the excitation energy supply unit 130. It is comprised so that it may irradiate to the positive electrode 121 which is this transparent electrode.

As shown in FIG. 19, the case 125 may be configured such that a light source irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion where the anode is mounted.

In the drawing, reference numeral 122a denotes an anode-side first moving inducer and 122b denotes an anode-side second movement inducing substance, respectively, and reference numeral 1 denotes air (exhalation) containing toluene as a detection target substance. Indicates.

The air (exhalation) 1 passes through the inside of the sensor electrode part 120 by a pump (not shown) located at the rear of the sensor electrode part 120, and a detailed description thereof will be omitted.

3) Detection system configuration

As shown in FIG. 15, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the system according to the present embodiment. Configure The power supply unit 180 supplies operating power to each component.

Preferably, the controller 150 is configured as a microprocessor or a computer system, and the data storage 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. desirable.

The data storage unit 140 stores a detection result of the detection target material and a data table indicating a correlation between the amount of detection target material and the amount of current.

Hereinafter, the operation of the present embodiment configured as described above will be described in detail.

First, when the light source 131 of the excitation energy supply unit 130 is turned on (ON), the light energy irradiated from the light source 131 is [Li ⁺ @ C60] [where the anode-side first moving inducer 122a is used. PF6 ⁻ ] and [TiO₂], the anode-side second moving inducer 122b, supply excitation energy.

Then, the electrons in the valence band of [TiO₂], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO₂]. The energy level of electrons excited by the conduction band of [TiO₂] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.

By the light energy irradiated from the light source 131, the electrons in the valence band of the anode-side first moving inducer [Li + @ C60] [PF6-] are excited to the conduction band, and the [Li + @ C60] [PF6-] A hole is generated in the valence band of. The energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO₂], which is the anode-side second moving inducer. The excited electrons move to the hole formed in the valence band of [TiO₂].

In this state, when toluene as a detection target material flows between FTO as a cathode and platinum (Pt) as a cathode, electrons (energy level: -6.55 eV) in the valence band of the toluene are the anode-side first inducing substance. The hole moves to the valence band of [Li + @ C60] [PF6-] (energy level: -7.70 eV), and the hole is generated in the valence band of toluene.

Then, the electrons (energy level: -5.93eV) in the valence band of platinum (Pt), which is a cathode, move to the hole (energy level: -6.55 eV) generated in the valence band of the toluene as the detection target material.

Thereafter, as long as the excitation energy is supplied from the excitation energy supply unit 130, the above process is repeated to move electrons proportionally to the toluene, the detection target material, from the cathode to the anode.

The detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.

The controller 150 detects whether or not current flows through the detection unit 110 to determine whether or not toluene as a detection target material is present, and determines the amount of toluene as a detection target material from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the target substance stored in the data storage unit and the current amount.

Thereafter, the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, such a process is repeatedly performed to continuously detect a detection target material.

In this case, by detecting the current flowing through the electrons donated from the detection target material, accurate and accurate detection in proportion to the number of molecules of the detection target material can be performed.

For reference, the data indicating the amount of toluene detected may be configured to diagnose the degree of cancer by referring to a data table indicating the amount of toluene and the degree of cancer progression.

The precision of the lung cancer sensor is described as follows.

The number of molecules in the expiration of about 500cc is about 1.19 × 10 ²² .

The number of molecules contained in 1 ppt of aerobic gas of 500 cc is

1.19 × 10 ²² × 10 ^-12 = 1.19 × 10 ¹⁰ .

If this is expressed as the amount of charge,

(1.19 × 10 ¹⁰ ) × (1.62 × 10 ^{) -19} C) = about 1.19 × 10 ^-9 C = 1.9 nA.

That is, even if 1ppt of the memorizing substance is contained in the expiration of 500cc it can be detected.

If 500 ppm of exhaled air contains 1% of memorizing substance in 1ppt of air, the charge amount is about 19pA.

Since the configuration of the detection unit 110 for detecting the charge amount in the nano-ampere (nA) or pico-ampere (pA) unit is well known, its detailed description is omitted.

On the other hand, in the present invention [C60] fullerene and lithium ion-encapsulated fullerene constituting a mobile induction material (anode-side mobile induction material, negative electrode-side mobile induction material) is about 1nm in size including an electron cloud, the lithium ion containing fullerene and The supramolecular molecule consists of pigments of about 2 nm in size.

Therefore, if the 500cc unit contains 1ppt of memorizing substance, and the mobile inducing substance is composed of ultra-molecules (about 2 nm) composed of lithium ion containing fullerene and pigment, the size of the electrode plate to react simultaneously with the memorizing substance is A size of about (0.22 mm ㅧ 0.22 mm) is sufficient. In the case where 1% of the memorized substance is present in 1 ppt of the 500cc, the positive electrode (or negative electrode) may be made of a smaller electrode plate.

That is, a lung cancer sensor having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the memorandous substance to move and directly detecting the number of moved electrons.

However, in the above embodiment, the detection of the detection target material using two anode-side movement inducing materials as an example, but the technical concept of the present invention is not limited to this. That is, as shown in Figs. 1 to 14, the molecular sensor of the present invention is constructed without a moving inducing substance or by using one anode-side inducing substance or one cathode side inducing substance. Or by constructing the molecular sensor of the present invention using a plurality of anode side movement inducing materials or a plurality of cathode side movement inducing materials, or as many anode side movement inducing materials as required and as many cathode side movements as necessary. It turns out that the molecular sensor according to the present invention can be configured by using all of the inducers. Fig. 16 is a diagram showing an example of the configuration of the sensor electrode part using both the anode side movement inducing material 122 and the cathode side movement inducing material 123.

In addition, in the above-described embodiment, the light source is supplied with an excitation energy supply unit, and the light source is limited to one, which has been described as an example. However, the technical spirit of the present invention is not limited thereto. That is, the excitation energy supply unit may be configured using several different light sources, and it may be configured to supply excitation energy using different energy sources.

In addition, in the above embodiment, the detection of the detection target material contained in the air has been described as an example, but the technical spirit of the present invention is not limited thereto. In other words, it can be configured to detect the detection target material contained in the liquid. For example, in the construction of the sensor electrode unit, the present invention can be configured to be configured to contain liquids (blood, urine, saliva, other liquids, etc.) or to temporarily stay, rather than to allow air to pass. Reveal.

In addition, in the above embodiment, the detection of only one detection target substance has been described as an example, but the technical spirit of the present invention is not limited thereto. In other words, it can be configured to detect a plurality of detection target material. For example, it will be appreciated that it can be configured to detect two or more detection target materials at the same time by using a plurality of anode-side inducing substances, a plurality of cathode-side inducing substances and a plurality of excitation energy supply units.

In addition, in the present embodiment, the technical idea of the present invention has been described with the example of detecting toluene, which is a cancerous substance, but the technical idea of the present invention is not limited thereto. That is, it can be configured to detect tuberculosis-related substances to diagnose tuberculosis early, to detect the cause of bad breath by detecting bad breathing substance), and to detect stress levels by detecting stress-causing substances. It can be configured to detect poisonous gas such as sarin gas, dioxin and the like, as well as the molecular sensor according to the present invention can be configured within the scope of the technical idea of the present invention without limiting the detection target material. Put it.

In addition, in the above embodiment, the detection of the amount of electrons moved by the detection target material has been described as an example, but the technical spirit of the present invention is not limited thereto. In other words, potentiostat is used to measure CV, measure CA, measure CP, measure SV, measure LSV, etc., to detect a substance to be detected as well as to measure the amount thereof. Can be. For example, as shown in FIG. 24, [TiO2] and [Li + @ C60] [PF6-] are moved to the FTO transparent electrode to form the working electrode W, and the counter electrode is formed of the platinum electrode Pt. (CE), a reference electrode (RE) made of silver chloride electrode (AgCl), mounted on a quartz glass test tube, and the target to be detected was placed in an electrolyte solution (eg, acetonitrile) and subjected to CV measurement. The presence and amount of can be measured. 25 is an enlarged graph of a portion of a CV curve, and shows a response according to energy level design of a substance ((curve) curve) and a substance ((curve) curve) to be detected. In the curve (a), when "a" is periodically switched on and off of light (excitation energy), excitation occurs at the anode-side induction material due to the excitation energy of light, resulting in a large amount of current (light irradiation). "B" shows when the light is not irradiated (the "b" section shows the state where the light source was turned off for convenience of explanation). At this time, it is possible to know the presence or absence of the detection target material by analyzing the difference of the current value or the graph characteristic. (B) The curve is not a substance to be detected, indicating that there is no change according to excitation energy (light irradiation).

In addition, as shown in FIG. 26, it is found that the detection target material can be specified by using quantum yield (IPCE) according to the wavelength of the light source supplied with excitation energy as a feature.

Example 2

Next, a cancer diagnosis system using the energy level, in particular a cancer diagnostic sensor will be described in detail.

In the drawings, the present invention is referred to FIGS. 28 and 29 and the drawings of the molecular sensor.

Like the molecular sensor described above, the cancer sensor using the energy level according to the present invention further includes a detection unit 110 for detecting the flow of electrons according to the dark matter, as shown in FIG. 15.

The detection unit 110 detects the flow of electrons moving from the cathode to the anode and calculates the amount, as well as whether the memorandous material is present. That is, the current and the voltage between the positive electrode and the negative electrode are detected to detect whether the memorandum is introduced and the amount thereof is detected.

In the above configuration, the display unit 160 for indicating the information on the flow of electrons according to the memorizing material; it characterized in that it further comprises a configuration.

The display unit 160 preferably includes a visual display unit 161 that visually displays information on the detection of a memorandum and an auditory display unit 162 that is auditory.

In the above configuration, the communication unit 170 for transmitting the information on the memorizing substance detection to the outside; further comprises.

The communication unit 170, the wired communication unit 171 for transmitting the information on the memorizing substance detection to a wire (dedicated line, dedicated network, Internet, etc.), and the information on the memorizing substance detection wireless (wireless communication, mobile communication, Short-range wireless communication, Wi-Fi, Bluetooth, etc.) is preferably composed of a wireless communication unit 172 for transmitting.

In the above configuration, the data storage unit 140 for storing the information on the memorandum detection, characterized in that it further comprises. In the drawing, reference numeral 150 denotes a controller, and 180 denotes a power supply unit for supplying operating power to each component.

Hereinafter, the technical concept of the "arm sensor using the energy level" of the present invention will be described in detail with reference to Examples.

In Example 1, the detection of 2,6-diisopropyl phenol (2,6-Diisopropylphenol), which is one of memorizing substances, will be described as an example.

In addition, in Example 1, an FTO (F-doped [SnO 2]) transparent electrode is used as the anode and platinum (Pt) is used as the cathode.

In addition, in Example 1, fullerene [C60] is used as an anode side movement inducing substance, and it demonstrates as an example.

Therefore, the sensor electrode part according to the first embodiment uses FTO as the anode, electrophoreses [C60] to the FTO, and uses platinum (Pt) as the cathode. In addition, the excitation energy supply unit for supplying excitation energy to the anode-side movement inducing material is further configured, and the excitation energy supply unit will be described as an example of supplying optical energy.

In addition, in the first embodiment, when the memorizing substance (2,6-diisoprophylphenol) is introduced into the sensor electrode unit, a detector for detecting the flow of electrons moving from the cathode to the anode, and the detection information (detection process, A display unit for displaying detection conditions, detection results, etc.), a data storage unit for storing the detection conditions, and a communication unit for exchanging information on the detection with an external device will be described as an example.

In addition, in this Example, the detection of 2, 6- diisoprofil phenol contained in air (exhalation) is demonstrated as an example. Therefore, the sensor electrode unit will be described with an example in which a structure in which air flows between the cathode and the anode is configured. The air (exhalation) containing the memorizing substance is supplied to the sensor electrode unit by using a pumping device.

The reason why the first embodiment is configured as described above is that other configurations and embodiments according to the technical idea of the present invention can be easily understood from the present embodiment.

Hereinafter, the configuration of the first embodiment configured as described above with reference to the accompanying drawings in detail as follows.

1) Energy level design

The energy level design process of Example 1 for detecting 2,6-diisoprophylphenol is described below with reference to FIG.

The energy level based on the vacuum of the valence band of 2,6-diisoprophylphenol, a memorized substance, is -5.93 eV, and the energy level of the conduction band is -0.01 eV. Therefore, the energy level of the negative electrode requires an electrode having an energy level higher than -5.93 eV, which is the energy level of the valence band of the memorized substance 2,6-diisoprophylphenol. In Example 1, platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode. Therefore, when 2,6-diisoprophyl phenol which is a memorized substance is contacted with a cathode made of platinum (Pt), electrons can move from the cathode to a hole generated in the valence band of 2,6-diisoprophyl phenol which is a memorized substance. It has an energy level structure.

2,6-diisoprophylphenol, the memorizing substance to be detected in Example 1, has a low energy level of -5.93 eV in the valence band, and thus an anode-side inducing substance having a lower energy level is required. In Example 1, [C60] having an energy level of -6.72 eV in the valence band is used as the anode-side inductive material. The energy level of the valence band of [C60] used as the anode-side inducing substance is lower than the energy level of the valence band of the 2,6-diisoprophylphenol, which is the base material, is -5.93 eV. The electrons in the valence band of soprophyllphenol have an energy level structure that can move to the positive holes generated in the valence band of [C60].

Since the energy level of the conduction band of [C60], which is the anode-side inductive substance, is -3.89 eV, and the energy level of the valence band of the FTO used as the anode, is -4.85 eV, the electrons excited in the conduction band of [C60] are anodes. It has an energy level structure that can move to.

That is, when the conditions are satisfied, electrons excited in the electron band of [C60], which is the positive electrode-side transfer inducing material, move to the anode, and 2,6-, which is a memorized substance, are holes generated in the valence band of [C60]. The electrons of the diisoprophyl phenol are moved, and the electrons move in the platinum (Pt), which is a cathode, as holes generated in the valence band of the 2,6-diisoprophyl phenol.

Excitation of [C60], which is the anode-side mobile induction material, requires a power of 2.83 eV or more, which has a wavelength of 438 nm. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions. For example, a halogen lamp that meets the above conditions can be used.

Figure 23 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, once the excitation process according to the energy level when the 2,6-diisoprophylphenol which is a memorandous material is introduced It is designed to move electrons from cathode to anode via

2) Sensor electrode part composition

21 to 23, the anode 121 and the cathode 124 are mounted inside the case 125 to form the sensor electrode 120 according to the first embodiment.

The operating power is supplied to the positive electrode 121 and the negative electrode 124 through a power supply unit 180, and the detection unit 110 is connected to detect a current flowing between the positive electrode 121 and the negative electrode 124. .

As shown in FIG. 20, the case 125 may be configured such that light irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion where the anode is mounted.

In the figure, reference numeral 122 denotes an anode-side moving inducer, and 1 denotes air (exhalation) containing 2,6-diisoprophylphenol, which is a memorandous substance.

3) Detection system configuration

As shown in FIG. 15, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the first embodiment. Configure the system. The power supply unit 180 supplies operating power to each component.

The data storage unit 140 stores a result of the detection of the memorized substance and a data table indicating a correlation between the amount of the substance to be detected and the amount of current.

Hereinafter, the operation of the first embodiment configured as described above will be described in detail.

First, when the light source 131 of the excitation energy supply unit 130 is turned on (ON), the excitation energy is supplied to [C60] that the light energy irradiated from the light source 131 is the anode-side movement inducing material 122 Done.

Then, the electrons in the valence band of [C60], which is the anode-side movement inducing material, are excited with a conduction band, and a hole is generated in the valence band of [C60]. The energy level of the electrons excited by the conduction band of [C60] is -3.89 eV, which is higher than the energy level of -4.85 eV of the valence band of the anode FTO, and the electrons excited by the conduction band move to the anode FTO.

In this state, when 2,6-diisoprophyl phenol, which is a memorizing substance, flows between FTO, which is an anode, and platinum (Pt), which is a cathode, electrons (energy levels) in the valence band of the 2,6-diisoprophyl phenol are : -5.93eV) moves to the positive hole (energy level: -6.72eV) generated in the valence band of [C60] which is the anode-side mobile induction material, and the positive hole is generated in the valence band of 2,6-diisoprophylphenol. Will be.

Then, the electrons (energy level: -5.93eV) in the valence band of platinum (Pt) as the positive hole generated in the valence band of the memorized substance 2,6-diisoprophylphenol (energy level: -5.93 eV) Will move.

Thereafter, as long as the excitation energy is supplied from the excitation energy supply unit 130, the above process is repeated, and the number of electrons proportional to the number of molecules of the 2,6-diisoprophylphenol, which is the base material, is from the cathode to the anode. Will continue to move.

The controller 150 detects whether current flows through the detector 110 to determine whether 2,6-diisoprophylphenol, which is a memorandous substance, is present, and the memorized substance is determined from the amount of current. The amount of 2,6-diisoprophylphenol is determined. That is, the amount of 2,6-diisoprophylphenol introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.

Thereafter, the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect the memorandum.

At this time, by detecting the current flowing through the electrons donated from the memorized material, accurate and precise detection in proportion to the number of molecules of the memorized material can be performed.

That is, the presence or absence of a memorandous substance is detected and the presence or absence of cancer cells is determined, and the extent of cancer is determined by the amount of the memorandum. Two or more types of cancers detected in the same sample are determined by the composition ratio of the cancer-causing substance.

The progress of cancer is determined by referring to the data table indicating the amount of cancer and the progress of cancer, and the type of cancer is determined by referring to the data table of the composition and the type of cancer.

The precision of the lung cancer sensor is described as follows.

The number of molecules contained in 1 ppt of aerobic gas of 500 cc is

1.19 × 10 ²² × 10 ^-12 = 1.19 × 10 ¹⁰ .

If this is expressed as the amount of charge,

In Example 2, the detection of toluene, which is one of memorizing substances, will be described as an example.

In Example 2, as in Example 1, FTO is used as the positive electrode and platinum (Pt) is used as the negative electrode.

In addition, in Example 2, titanium dioxide (TiO2) and anode-side first lithium-included fullerene hexafluorophosphate salt ([Li + c60] [PF6-]) were used as the anode-side second moving inducer. It demonstrates as an example.

Therefore, the sensor electrode part according to the first embodiment uses FTO as an anode, electrophoreses [TiO2] and [Li + c60] [PF6-] to the FTO, and uses platinum (Pt) as the cathode. In addition, the excitation energy supply unit for supplying excitation energy to [TiO2] and [Li + c60] [PF6-] is further configured, and the excitation energy supply unit will be described with an example of supplying optical energy.

In the second embodiment, as in the first embodiment, a detection unit, a display unit, a data storage unit, and a communication unit are described as an example, and the detection of toluene contained in air (exhalation) will be described as an example. .

The reason why the present embodiment 2 is configured as described above is that other configurations and embodiments according to the technical idea of the present invention can be easily understood from the present embodiment.

Hereinafter, the configuration of the second embodiment as described above with reference to the accompanying drawings in detail as follows.

1) Energy level design

An energy level design process of the second embodiment for detecting toluene will be described with reference to FIG. 18 as follows.

The energy level based on the vacuum of the valence band of toluene, the memorized substance, is -6.55 eV, and the energy level of the conduction band is -0.18 eV. Therefore, the energy level of the cathode requires an electrode having an energy level higher than -6.55 eV, which is the energy level of the valence band of the toluene. In the second embodiment, platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode. Therefore, when toluene, which is a memorized substance, comes into contact with a cathode made of platinum (Pt), has an energy level structure in which electrons can move from the cathode to holes formed in the valence band of toluene, which is a memorized substance, by the energy level difference.

Toluene, which is a memorized substance to be detected in Example 2, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inductive substance having a lower energy level is required. In this embodiment, [Li + @ C60] [PF6-] having an energy level of -7.70eV in the valence band is used as the anode-side first inducing substance. The energy level of the valence band of [Li + @ C60] [PF6-], which is used as the anode-side first moving inducer, is lower than the energy level of the valence band of the toluene, which is the base material, of -6.55 eV. The electrons have an energy level structure that can move to the positive holes in the valence band of [Li + @ C60] [PF6-].

Since the energy level of the conduction band of [Li + @ C60] [PF6-], which is the anode-side first moving induction material, is -4.90 eV, and the energy level of the valence band of FTO used as the anode is -4.85 eV, the [Li + @ C60 ] The electrons in the conduction band of [PF6-] cannot move directly to the anode. Therefore, a positive electrode-side second moving material is required.

The energy level of the conduction band of [Li + @ C60] [PF6-], the anode-side first induction material, is -4.90 eV, and the energy level of the valence band of the anode FTO is -4.85 eV. What is needed is a material consisting of a valence band with an energy level lower than eV and a conduction band with an energy level higher than -4.85 eV.

Titanium dioxide (TiO2) has the energy level of the valence band of -6.21 eV and the conduction band of energy of -3.21 eV, which satisfies the above conditions. do. Then, the electrons excited in the conduction band of [TiO 2] have an energy level structure that can move to the anode.

That is, when the conditions are satisfied, the electrons excited in the electron band of [TiO2], which is the anode-side second moving inducing material, move to the anode, and the positive holes generated in the valence band of [TiO2] are [ Electrons excited in the conduction band of Li + @ C60] [PF6-] move, and electrons of toluene, which is a memorized substance, move to the hole generated in the valence band of [Li + @ C60] [PF6-], and the home appliances of the toluene The positive holes in the magnetic field cause the electrons to move in the platinum (Pt) cathode.

[Li + @ C60] [PF6-], which is the anode-side first mobile induction material, requires a power of 2.8 eV or more with a light source having a wavelength of 457 nm, and a wavelength of 413 nm for the [TiO2], which is an anode-side second mobile inductive material. Power of 3.0 eV or more is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions.

Figure 18 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, when toluene is a memorandous substance is introduced into the electron from the cathode to the anode through two excitation processes according to the energy level It is designed to move.

2) Sensor electrode part composition

As shown in FIG. 21, the cathode 121 and the cathode 124 are mounted inside the case 125, and operation power is supplied to the anode 121 and the cathode 124 through the power supply unit 180. In addition, the sensor 110 is connected to the detector 110 so as to detect a current flowing between the anode 121 and the cathode 124.

The case 125 has a surface on which the anode 121, which is a transparent electrode, is mounted, or the entire case is made of a transparent material, and the light supplied from the light source 131, which is the excitation energy supply unit 130, is the anode 121, which is a transparent electrode. Configure it to be investigated.

In the figure, reference numeral 122a denotes an anode-side first moving inducer, and 122b denotes an anode-side second moving inducer, and (1) represents air (exhalation) containing toluene, which is a memorizing substance.

The air (exhalation) 1 is configured to pass through the inside of the sensor electrode part 120 by a pump (not shown) located at the rear of the sensor electrode part 120.

3) Detection system configuration

As shown in FIG. 15, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the second embodiment. Configure the system. The power supply unit 180 supplies operating power to each component.

Hereinafter, the operation of the second embodiment configured as described above will be described in detail.

First, when the light source 131 of the excitation energy supply unit 130 is turned on (ON), the light energy irradiated from the light source 131 is [Li + @ C60] [PF6] being the anode-side first moving inducer 122a. Excitation energy is supplied to [TiO 2], which is the negative electrode-side second moving inducer 122b.

Then, the electrons in the valence band of [TiO2], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO2]. The energy level of electrons excited by the conduction band of [TiO2] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.

By the light energy irradiated from the light source 131, the electrons in the valence band of the anode-side first moving inducer [Li + @ C60] [PF6-] are excited to the conduction band, and the [Li + @ C60] [PF6-] A hole is generated in the valence band of. The energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO2], which is the anode-side second moving inducer. The excited electrons are moved to the holes generated in the valence band of [TiO 2].

In this state, when the toluene, which is a memorizing substance, is introduced between the anode, FTO, and the cathode, platinum (Pt), the electrons (energy level: -6.55 eV) in the valence band of the toluene are the anode-side first moving inducing substance. The hole moves to the valence band of [Li + @ C60] [PF6-] (energy level: -7.70 eV), and the hole is generated in the valence band of toluene.

Then, the electrons (energy level: -5.93eV) in the valence band of platinum (Pt), which is a cathode, move to the hole (energy level: -6.55eV) generated in the valence band of the toluene, which is the memorizing substance.

Thereafter, as long as the excitation energy is supplied by the excitation energy supply unit 130, the above process is repeated, and the number of electrons proportional to the toluene, which is the base material, is continuously moved from the cathode to the anode.

The control unit 150 detects whether current flows through the detection unit 110 to determine whether or not toluene, which is a memorandant, is present, and determines the amount of toluene, which is a memorized substance, from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.

That is, the presence of cancer cells is detected by the presence or absence of toluene, which is a cancerous substance, and the progress of cancer is determined by the amount of the cancerous substance. The type of cancer is determined by the composition ratio of two or more cancer-causing substances detected in the same sample (for example, the composition ratio of toluene and 2,6-diisoprophylphenol, or toluene, 2,6-diisoprophylphenol, 2- Composition of methyl pyrazine, cyclohexanone, etc.)

However, in the above embodiments, it has been described with the example of detecting the memorizing material using two anode-side movement inducing material, it is clear that the present invention is not limited to this. That is, as shown in Figs. 1 to 14, the arm sensor of the present invention is configured without a moving induction material, or the cancer sensor of the present invention using a plurality of anode-side movement inducing materials or a plurality of cathode-side movement inducing materials. Or it can be understood that the cancer sensor according to the present invention can be configured by using both the required number of the anode-side induction material and the required number of cathode-side movement inducing material. Fig. 16 is a diagram showing an example of the configuration of the sensor electrode part using both the anode side movement inducing material 122 and the cathode side movement inducing material 123.

In addition, in the above embodiment, it has been described with an example of detecting the dark base material contained in the air, but the technical spirit of the present invention is not limited thereto. In other words, it can be configured to detect the memorizing substance contained in the liquid. For example, in the construction of the sensor electrode unit, the present invention can be configured to be configured to contain liquids (blood, urine, saliva, other liquids, etc.) or to temporarily stay, rather than to allow air to pass. Reveal.

In addition, in the above embodiment, it has been described with the example of detecting one memorizing substance, but the technical idea of the present invention is not limited thereto. In other words, it can be configured to detect a plurality of memorandous substances. For example, it can be configured to detect two or more memorizing substances at the same time by using a plurality of anode-side inducing substances or a plurality of cathode-side inducing substances and a plurality of excitation energy supply units.

In addition, in the present embodiment, the technical idea of the present invention has been described with an example of detecting toluene and 2,6-diisoprophylphenol in the base material, but the technical idea of the present invention is not limited thereto. That is, it can be configured to detect toluene, 2,6-diisoprophylphenol, 2-methylpyrazine, cyclohexanone, and other memorandants.

Third Embodiment

The third embodiment according to the present invention is to capture the exhalation, and to use it to diagnose cancer, especially lung cancer.

The present invention, as shown in Figures 30 to 32, the sensor electrode portion 120 is designed for the energy level of the redox potential to move the electrons from the cathode to the anode via a memorandum material contained in the expiration; An excitation energy supply unit 130 for supplying excitation energy of electrons to the sensor electrode portion; A detection unit 110 for detecting electron movement of the sensor electrode unit 120; A display unit 160 showing the detection contents of the detection unit 110; A data storage unit 140 for storing detection contents of the detection unit; Communication unit 170 for transmitting the detection information; A control unit 150 connected to the sensor electrode unit 120, the excitation energy supply unit 130, the detection unit 110, the data storage unit 140, the display unit 160, and the communication unit 170; And a power supply unit 180 for supplying operation power to each of the components, and detecting and displaying a memorizing substance in the exhalation flowed into the sensor electrode unit 120. .

The present invention is such that when the subject breath is introduced between the cathode and the anode of the sensor electrode unit 120, the sensor to move the electron from the cathode to the anode via the electrons donated from the memorandum included in the breath The energy level of the redox potential of each component constituting the electrode part is designed.

That is, the energy level is designed so that the number of electrons proportional to the memorandum contained in the exhalation moves from the cathode to the anode, and the presence or absence of the memorandum is detected by detecting whether the electrons move (current flow). It determines whether or not, by detecting the degree of movement of the electrons (current amount) to accurately determine the amount of the memorizing substance introduced, and whether the lung cancer has occurred and whether or not the cancer occurs from the type and amount of the memorizing substance, the data storage unit The data is stored in the display unit 140, displayed on the display unit 160, and transmitted to the external device through the communication unit 170.

Since the movement of electrons is proportional to the number of molecules of the memorandum, the memorandum can be detected in molecular units, and real-time detection is possible by indicating the amount of the memorandum as an amount of current.

In the above configuration, as shown in Figure 25, the breathing apparatus 190 for collecting the breath of the subject; characterized in that it further comprises.

The exhalation collecting device 190 is for easily collecting the exhalation of the subject to supply to the sensor electrode unit 120.

The memorandum is a cancer metabolite that is caused by cancer, and the discovery of this memorandum means that there are cancer cells in the body.

Memorandizers include toluene, 2,6-diisopropylphenol, 2-methylpyrazine, cyclohexanone, and the like. When the memorizing substance is detected, the type of the memorizing substance is determined, the ratio of each memorizing substance is judged to determine the type of cancer, and the amount of the memorizing substance is detected to determine the progress of the cancer.

As described above, the excitation energy supply unit 130 may include an optical energy supply unit (not shown), an electromagnetic wave energy supply unit (not shown), or a thermal energy supply unit (not shown) for supplying energy above the band gap energy between the valence band and the conduction band as described above. It is characterized by consisting of any one or more of).

On the other hand, the sensor electrode 120 applied to the third embodiment of the present invention is the same as Figs. 21 to 23, the energy level design of the configuration 1 to 7 and the other configuration of the first embodiment is used.

A third embodiment will be described below.

1) Composition of Exhalation Collector

As shown in FIGS. 30 and 32, the exhalation collecting device 190 fits an exhalation pocket 193 into the inside of the quantitative jacket 194, and an exhalation inlet pipe 191 and one side of the exhalation pocket 193. It is provided with the inflow opening and closing means 192, and is provided with the air outlet pipe 196 and the outflow opening and closing means 197 on the opposite side.

2) Energy level design of sensor electrode

The energy level design process of Example 1 for detecting 2,6-diisoprofil phenol is described with reference to FIG.

In the present embodiment, 2,6-diisoprophylphenol, which is a memorized substance to be detected, has a low energy level of -5.93 eV in the valence band, and thus an anode-side inductive substance having a lower energy level is required. In Example 1, [C60] having an energy level of -6.72 eV in the valence band is used as the anode-side inductive material. The energy level of the valence band of [C60] used as the anode-side inducing substance is lower than the energy level of the valence band of the 2,6-diisoprophylphenol, which is the base material, is -5.93 eV. The electrons in the valence band of soprophyllphenol have an energy level structure that can move to the positive holes generated in the valence band of [C60].

Figure 29 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, once the excitation process according to the energy level when the 2,6-diisoprophylphenol which is a memorandous material is introduced It is designed to move electrons from cathode to anode via

3) Sensor electrode part composition

As shown in FIGS. 18 to 20, the sensor electrode unit 120 according to the first embodiment is configured by mounting the anode 121 and the cathode 124 in the case 125.

As shown in the figure, the case 125 may be configured such that the light irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion where the anode is mounted.

In the figure, reference numeral 122 denotes an anode-side movement inducing substance, and (1) denotes an exhalation (exhalation) containing 2,6-diisoprophylphenol which is a memorizing substance.

The exhalation (exhalation) 1 passes through the inside of the sensor electrode unit 120 by a pump (not shown) located at the rear of the sensor electrode unit 120, and a detailed description thereof will be omitted.

As shown in FIG. 30, the aerobic collecting device 190 is coupled to the sensor electrode unit 120 configured as described above through a coupling structure.

4) System Configuration

As shown in FIG. 1, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the first embodiment. Configure the system. The power supply unit 180 supplies operating power to each component.

The data storage unit 140 stores a detection result of 2,6-diisoprophyl phenol, which is a memorizing substance, and a data table showing a correlation between the amount of 2,6-diisoprophyl phenol and the amount of current.

First, as shown in Fig. 32, exhalation is collected. When the operator bites and blows the exhalation inlet pipe 191 into the mouth as shown in (a), the inflow opening and closing means 192 is opened by the blowing force as shown in Fig. 32 (b), and the exhalation pocket 193 This swells and exhalation is collected in the collecting space 195.

Thereafter, as shown in FIG. 32 (c), the exhalation collecting device 190 is attached to the sensor electrode unit 120. Then, the exhalation opening means 197 provided in the exhalation outlet pipe 196 by the exhalation induction pipe 127 is opened to supply the exhalation to the sensor electrode unit 120 through the exhalation induction pipe 127.

Figure 32 (d) shows that when the exhalation pocket 193 is made of a flexible material such as rubber, the exhalation flows out through the exhalation guide pipe 127 by its elastic force, Figure 28 (e) When the exhalation pocket 193 is made of a material having no elasticity, such as vinyl, it shows that exhalation is supplied to the sensor electrode unit 120 through the fan 126.

The exhalation preferably uses a fan 126, as shown in Figure 32 (e). When the fan 126 is used, it is possible to control the amount of exhaled air supplied and whether it is supplied.

When the exhaled air collected in the exhalation trap device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, the light source 131 of the excitation energy supply unit 130 is turned on (ON), The light energy irradiated from the light source 131 supplies excitation energy to [C60], which is the anode-side movement inducing material 122.

In this state, when the 2,6-diisoprophyl phenol, which is a memorandous substance contained in the aerobic phase, flows between the positive electrode FTO and the negative electrode platinum (Pt), the 2,6-diisoprophyl phenol is in the valence band of the 2,6-diisoprophyl phenol. The electrons (energy level: -5.93 eV) move to the hole (energy level: -6.72 eV) generated in the valence band of [C60] which is the anode-side transfer inducing substance, and the valence band of the 2,6-diisoprophylphenol. Holes will be generated in.

In other words, the presence or absence of a memorandum contained in the expiration is detected whether the presence of cancer cells, and the extent of cancer is determined by the amount of the memorandum. Two or more types of cancers detected in the same sample are determined by the composition ratio of the cancer-causing substance.

The precision of the lung cancer sensor is described as follows.

The number of molecules contained in 1 ppt of aerobic gas of 500 cc is

1.19 × 10 ²² × 10 ^-12 = 1.19 × 10 ¹⁰ .

If this is expressed as the amount of charge,

In Example 2, the detection of toluene, which is one of the cancer-causing substances that occur when lung cancer occurs, will be described as an example.

In the present Example 2, titanium dioxide (TiO 2) and the positive electrode 1 lithium-pothofullerene hexafluorophosphate salt ([Li + c60] [PF6-]) were used as the anode-side second moving inducer. The example used is demonstrated.

Therefore, the sensor electrode part according to the present Example 2 uses FTO as an anode, electrophoreses [TiO2] and [Li + c60] [PF6-] to the FTO, and uses platinum (Pt) as the cathode. do. In addition, the excitation energy supply unit for supplying excitation energy to [TiO2] and [Li + c60] [PF6-] is further configured, and the excitation energy supply unit will be described with an example of supplying optical energy.

In the second embodiment, as in the first embodiment, a detection unit, a display unit, a data storage unit, and a communication unit are described as an example, and the detection of toluene contained in the exhalation (exhalation) will be described as an example. .

The reason why the present Embodiment 2 is configured is because other configurations and embodiments according to the technical spirit of the present invention can be easily understood from the present embodiment.

Hereinafter, the configuration of the present embodiment 2 will be described in detail with reference to the accompanying drawings.

1) Composition of Exhalation Collector

Same as <Example 1>.

2) Energy level design of sensor electrode

An energy level design process of the second embodiment for detecting toluene will be described with reference to FIG. 30 as follows.

The energy level based on the vacuum of the valence band of toluene, the memorized substance, is -6.55 eV, and the energy level of the conduction band is -0.18 eV. Therefore, the energy level of the cathode requires an electrode having an energy level higher than -6.55 eV, which is the energy level of the valence band of the toluene. In Example 2, platinum (Pt) whose energy level of the valence band is -5.93 eV and the energy level of the conduction band is -5.12 eV is used as the cathode. Therefore, when toluene, which is a memorized substance, comes into contact with a cathode made of platinum (Pt), has an energy level structure in which electrons can move from the cathode to holes formed in the valence band of toluene, which is a memorized substance, due to the difference in energy levels.

Toluene, which is a memorized substance detected in <Example 2>, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inductive substance having a lower energy level is required. In Example 2, [Li + @ C60] [PF6-] having the valence band energy level of −7.70 eV is used as the anode-side first moving inducing substance. The energy level of the valence band of [Li + @ C60] [PF6-], which is used as the anode-side first moving inducer, is lower than the energy level of the valence band of the toluene, which is the base material, of -6.55 eV. The electrons have an energy level structure that can move to the positive holes in the valence band of [Li + @ C60] [PF6-].

Figure 30 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, when toluene is a memorandous material is introduced into the electron from the cathode to the anode through two excitation processes according to the energy level It is designed to move.

3) Sensor electrode part composition

As shown in FIGS. 21 to 23, the cathode 121 and the cathode 124 are mounted inside the case 125, and operating power is supplied to the anode 121 and the cathode 124 through the power supply unit 180. The sensor electrode unit 120 according to the second embodiment is configured by connecting the detection unit 110 so as to supply and detect a current flowing between the anode 121 and the cathode 124.

In the figure, reference numeral 122a denotes an anode-side first moving inducer, and 122b denotes an anode-side second moving inducer, and (1) denotes an exhalation (exhalation) containing toluene, which is a cancerous substance.

The exhalation (exhalation) 1 is configured to pass through the inside of the sensor electrode 120 by a pump (not shown) located in the rear of the sensor electrode 120.

4) System Configuration

As shown in FIG. 26, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the second embodiment. Configure the system. The power supply unit 180 supplies operating power to each component.

The data storage unit 140 stores a result of detection of toluene and a data table indicating a correlation between the amount of toluene and the amount of current.

Hereinafter, the operation of the present Embodiment 2 configured as described above will be described in detail.

When the exhaled air collected in the exhalation trap device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, the light source 131 of the excitation energy supply unit 130 is turned on (ON), The light energy irradiated from the light source 131 supplies excitation energy to [Li + @ C60] [PF6-], which is the anode-side first movement inducing material 122a, and [TiO2], which is the anode-side second movement inducing material 122b. do.

Example 4

A fourth embodiment according to the present invention relates to a portable cancer diagnosis system using energy levels.

This system uses electrons from the cathode to the anode, especially through donations from memorandum (a substance that is caused by cancer) contained in body fluids (blood, urine, sweat, tears, runny nose, etc.). By designing the energy level of the redox potential to move, it is possible to make a precise diagnosis on a molecular basis.

In this embodiment, 1) the first and second anode energy level designs are constructed in the same manner as the energy level designs of the second and third embodiments, that is, the second and third embodiments based on FIGS. The electrode portion is as follows.

2) Sensor electrode part

As shown in FIG. 34, the first anode 121a, the cathode 124, and the second anode 121b are zigzag formed on the transparent substrate. One side of the first positive electrode 121a, the negative electrode 124 and the second positive electrode 121b is provided with a connection pattern so as to be inserted into and connected to the connector 120b provided in the portable arm diagnosis apparatus 100 according to the present embodiment. The sensor electrode unit 120 according to the embodiment is configured.

The first anode 121a and the second cathode 121b are doped with a moving induction material by electrophoresis.

The first anode 121a, the cathode 124, and the second anode 121b are provided with an absorbent cloth 126 of a thin film, and when the body fluid is dropped onto the absorbent cloth 126, the first anode is spread evenly. The medicine may be evenly contacted with the 121a, the cathode 124, and the second anode 121b.

Thereafter, operating power is supplied to the first positive electrode 121a, the negative electrode 124 and the second positive electrode 121b through the power supply unit 180, and the first positive electrode 121a, the negative electrode 124, The

detection units

110a and 110b are connected to detect a current flowing between the second anodes 121b.

As shown in FIG. 1, the portable cancer diagnosis apparatus 100 according to the present embodiment is provided with a connector 120b to which the sensor electrode part 120a is connected, and each electrode of the sensor electrode part 120a is provided. The light source 131a of the excitation energy supply unit 130 is positioned below the first anode, the cathode, and the second anode, and is configured to supply light energy to the sensor electrode unit 120a through a transparent window.

3) System Configuration

33 to 38, the light source 131a of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the

detection units

110a and 110b are applied to the sensor electrode unit 120a. Connect it. Thereafter, the

detectors

110a and 110b, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, the communication unit 170, and the switch unit 190 are connected to the control unit 150. It connects and comprises the detection system which concerns on a present Example. The power supply unit 180 supplies operating power to each component.

Preferably, the controller 150 is configured as a microprocessor or a small computer system. The data storage unit 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. This is preferred.

The visual display unit 161 of the display unit 160 includes a touch screen 161a, and the auditory display unit 162 includes a speaker 162a embedded in the portable cancer diagnosis apparatus 100, and the communication unit 170 Wired communication unit 171 of the) is preferably configured to communicate through the USB connection device (171a). The wireless communication device 172 is composed of Bluetooth and Wi-Fi (not shown).

The switch unit 190 is configured on the touch screen that forms the button-type switch 191 and the visual display unit 161a.

The data storage unit 140 includes a detection result of the 2,6-diisoprophylphenol phenol, which is a memorizing substance, a data table showing the correlation between the amount of the 2,6-diisoprophyl phenol and the current amount, the detection result of toluene, A data table and the like showing the correlation between the amount of toluene and the amount of current are stored.

First, as shown in FIG. 34, the sensor electrode portion 120a is mounted on the connector 120b.

Thereafter, a drop of body fluid is dropped onto the absorbent cloth 126 of the sensor electrode 120a.

As a result, the body fluid dropped on the absorbent cloth 126 is evenly spread to contact the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b evenly.

In this state, electron movement (current) of the cathode 124 and the first anode 121a and the cathode 124 and the second anode 121b is performed through the first detector 110a and the second detector 110b. Detect. That is, the electron movement is detected while the off state of the light source 131a of the excitation energy supply unit 130 is maintained.

This initial detection is for detecting the current value by the body fluid itself in a state where the excitation energy supply unit 130 is not operated, that is, there is no electron movement by the memorandous substance. This initial detection value is for calculating only the value of the electron transfer which causes the memorandable substance compared with the detection value by the memorable substance.

Thereafter, the light source 131a of the excitation energy supply unit 130 is turned on to detect electron movement in the state where the excitation energy is supplied to the sensor electrode unit 120a. Then, the electron transfer by the memorandum contained in the body fluid occurs to detect the value including the value by the memorandum in the initial detection value, the initial detection value is removed from the detection value containing the memorandum The electron transfer value by the memorandum can be known, and the kind and the progress of the cancer can be determined from the presence, the amount, and the composition ratio of each memorandum.

On the other hand, in the present embodiment will be described in detail the electron transfer process caused by the memorized material in the first anode (121a) and the second anode (121b) as follows.

In the present embodiment, since the first anode 121a detects 2,6-diisoprophylphenol, which is a memorandous substance contained in the body fluid, and uses [C60] as an anode-side inducing substance, it will be described. .

First, when the light source 131a of the excitation energy supply unit 130 is turned on while the body fluid is supplied to the sensor electrode unit 120a, the light energy irradiated from the light source 131a is transferred to the anode side induction material ( Excitation energy is supplied to [C60].

Then, as illustrated in FIG. 17, electrons in the valence band of the anode-side movement inducing material [C60] are excited as conduction bands, and holes are generated in the valence band of [C60]. The energy level of the electrons excited by the conduction band of [C60] is -3.89 eV, which is higher than the energy level of -4.85 eV of the valence band of the anode FTO, and the electrons excited by the conduction band move to the anode FTO.

In addition, the hole (energy level: -6.72eV) in which the electron (energy level: -5.93eV) in the valence band of the 2,6-diisoprophylphenol is generated in the valence band of [C60] which is the anode-side mobile inducer In the valence band of the 2,6-diisoprophylphenol phenol, holes are generated.

Thereafter, the same process is repeated as long as the excitation energy is supplied from the light source 131a of the excitation energy supply unit 130, and the 2,6-diisoprofil which is the memorized substance from the cathode to the first anode 121a is then repeated. The number of electrons in proportion to the number of molecules of the phenol is constantly moving.

The first detector 110a detects a current (movement of electrons) flowing between the cathode 124 and the first anode 121a.

The controller 150 detects whether a current flows through the first detection unit 110a to determine whether 2,6-diisoprophylphenol, which is a memorandum, is present, and memorizes from the amount of current. The amount of 2,6-diisoprophylphenol which is a substance is determined. That is, the amount of 2,6-diisoprophylphenol introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.

In the present exemplary embodiment, toluene, which is a memorized substance contained in the body fluid, is detected at the second anode 121b, and [Li + @ C60] [PF6-] is used as the anode-side first movement inducing substance, and the anode-side second movement induction. Since [TiO 2] is used as an example, it will be described.

First, when the light source 131a of the excitation energy supply unit 130 is turned on while the body fluid is supplied to the sensor electrode unit 120a, the light energy irradiated from the light source 131a is the anode-side first moving inducing material. Excitation energy is supplied to [Li + @ C60] [PF6-] (122a) and [TiO2], which is the anode-side second moving inducer 122b.

By the light energy irradiated from the light source 131a, electrons in the valence band of [Li + @ C60] [PF6-], which are anode-side first moving induction materials, are excited as conduction bands, and [Li + @ C60] [PF6-] A hole is generated in the valence band of. The energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO2], which is the anode-side second moving inducer. The excited electrons are moved to the holes generated in the valence band of [TiO 2].

In addition, the holes (energy level: -6.55eV) in the valence band of toluene are generated in the valence band of [Li + @ C60] [PF6-] which is the anode-side first moving inducer (energy level: -7.70eV) It moves to and the hole is generated in the valence band of toluene.

Thereafter, the same process is repeated as long as the excitation energy is supplied from the light source 131a of the excitation energy supply unit 130 to be proportional to the toluene which is the memorized substance from the cathode 124 to the second anode 121b. The number of electrons are constantly moving.

The second detector 110b detects a current (movement of electrons) flowing between the cathode 124 and the second anode 121b.

The controller 150 determines whether current is flowing through the second detector 110b to determine whether or not toluene, which is a cancerous substance, is present, and determines the amount of toluene, which is a cancerous substance, from the amount of current. Done. That is, the amount of toluene introduced is calculated by comparing the detected current amount with the data table indicating the relationship between the amount of the memorizing substance and the current amount stored in the data storage 140.

That is, the presence of cancer cells is detected by the presence or absence of toluene, which is a cancerous substance, and the progress of cancer is determined by the amount of the cancerous substance.

The type of cancer is determined by the composition ratio of two or more cancer-causing substances detected in the same sample (for example, the composition ratio of toluene and 2,6-diisoprophylphenol, or toluene, 2,6-diisoprophylphenol, 2- Composition of methyl pyrazine, cyclohexanone, etc.)

The precision of the portable cancer diagnostic apparatus according to the present invention will be described as follows. Since the molecular weight of the body fluid varies depending on the type of body fluid, it will be described based on water.

The volume of one drop of liquid dropped into the dropper is about 0.05 cc.

So the number of molecules in a drop of water is

(0.00005ℓ / 18ℓ) × (6.02 × 10 ²³ ) ≒ 1.67 × 10 ¹⁸ pieces.

The number of molecules contained in 1 ppt of this 0.05cc of water is

(1.67 × 10 ¹⁸ ) × 10 ^-12 = 1.67 × 10 ⁶

If this is expressed as the amount of charge,

(1.67 x 10 ⁶ ) x (1.62 x 10 ^-19 C) = approximately 1.99 x 10 ^-11 C ≒ 20 pA.

That is, even if 1ppt of the memorized substance is contained in 0.05cc of water, it can be detected.

Since the configuration of the detection unit 110 for detecting the charge amount in the nano ampere (nA) or the picoampere (pA) unit is well known, its detailed description is omitted.

Therefore, it is said that there is 1 ppm of the memorandable substance in the 0.05cc water, and the mobile inducing substance is composed of ultra-molecules (about 2 nm) composed of lithium ion containing fullerene and a pigment. Should be about (0.22mm ㅧ 0.22mm).

That is, a lung cancer diagnosis apparatus having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the memorandant to be moved and directly detecting the number of moved electrons.

Urine consists of 95% water and 5% other components (urea, uric acid, etc.). The molecular weight of water is about 18, the molecular weight of urea is about 60, and the molecular weight of uric acid is about 168.

Example 5

Embodiment 5 of the present invention is a portable cancer diagnosis system using a smartphone.

This system is basically the same as the energy level design of Examples 1 to 4, and the sensor electrode portion is the same as Example 4. Therefore, the sensor electrode of this example will be described with reference to FIG. 34, and the system configuration will be described with reference to FIG. 30.

The cancer diagnosis system according to the present invention is a portable detection device for detecting a cancer-causing substance by setting the energy level of the redox potential so that electrons are moved from the cathode to the anode via the cancer-causing substance contained in the body fluid, and the portable detection Comparing and analyzing the measured value measured by the device is a cancer diagnostic app indicating the presence or absence of cancer memorandum and cancer, and the cancer diagnostic app is installed, and includes a smart phone for communicating with the mobile detection device.

The cancer diagnostic app is to determine the presence of cancer in the presence or absence of the memorandum, and to determine the progress of the cancer by the amount of the memorandum.

As shown in FIG. 34, the basic configuration of the cancer diagnosis system using the smart phone enables the light source 131a of the excitation energy supply unit 130 to be irradiated to the sensor electrode unit 120, and the sensor electrode unit ( The

detectors

110a and 110b are connected to the 120a. Thereafter, the

detectors

110a and 110b, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, the communication unit 170, and the switch unit 190 are connected to the control unit 150. By connecting, the portable detection device 100 according to the present embodiment is configured. The power supply unit 180 supplies operating power to each component.

The visual display unit 161 of the display unit 160 is composed of a touch screen 161a, the auditory display unit 162 is composed of a speaker 162a built in the portable detection device 100, the communication unit 170 Wired communication unit 171 is preferably configured to communicate through the USB connection device (171a). The wireless communication device 172 is composed of Bluetooth and Wi-Fi (not shown).

On the other hand, the memory (not shown) of the smartphone 200, the data table showing the correlation between the result of the detection of 2,6-diisoprophylphenol phenol, and the amount and current amount of 2,6-diisoprophylphenol, The detection result of toluene, and a data table showing the correlation between the amount of toluene and the amount of current are stored.

First, as shown in Figs. 36 and 38, the sensor electrode portion 120a is mounted on the connector 120b.

This initial detection is for detecting the current value by the body fluid itself in a state where the excitation energy supply unit 130 is not operated, that is, there is no electron movement by the memorandous substance. This initial detection value is for calculating only the value of the electron transfer caused by the memorandum substance compared with the detection value by the memorandum substance in the cancer diagnostic app 300.

40 shows a diagnosis process of the cancer diagnosis system using the smart phone.

Example 6

It is for diagnosing lung cancer most feared by modern people in the cancer detection system using exhalation.

The sensor electrode part of this system is preferably composed of the sensor electrode part of FIGS. 43 to 45 attached thereto.

That is, as shown, the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b are formed inside the transparent rectangular tube base material. The first anode 121a and the second cathode 121b are doped with a moving induction material by electrophoresis.

The operating power is supplied to the first positive electrode 121a, the negative electrode 124 and the second positive electrode 121b through the power supply unit 180, and the first positive electrode 121a, the negative electrode 124, The

detectors

110a and 110b are connected to detect a current flowing between the two anodes 121b.

As shown in FIG. 2, the left and right exhalation inlets and outlets of the sensor electrode unit 120a are fitted with an exhalation induction pipe 126a for inducing exhalation and an exhalation exhalation pipe 126b for exhalation. .

The mouthpiece 127 is inserted into the exhalation induction pipe 126a so as to inhale it and blow the exhalation.

Then, the exhalation passes through the exhalation induction pipe 126a, the inside of the sensor electrode part 120a, and the exhalation outlet pipe 126b, and the first anode 121a configured in the sensor electrode part 120a in the process. ), The cathode 124 and the second anode 121b are uniformly contacted.

The excitation energy supply unit 130 is installed at a position capable of supplying optical energy to the sensor electrode unit 120a, and the anode-side moving induction material by energy supplied from the light source 131 of the excitation energy supply unit 130. This is configured to be excited.

Diagnostic device configuration

The basic configuration is as shown in Figs. 41 and 45, and the system is referred to Fig. 35 for the configuration. The light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120a, and the

detection units

110a and 110b are connected to the sensor electrode unit 120a. Thereafter, the

detectors

110a and 110b, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, the communication unit 170, and the switch unit 190 are connected to the control unit 150. The present embodiment is constructed by connecting. The power supply unit 180 supplies operating power to each component.

The visual display unit 161 of the display unit 160 includes a touch screen 161a, the auditory display unit 162 includes a speaker 162a embedded in the body 100a, and the wired communication unit of the communication unit 170. 171 is preferably configured to communicate via the USB connection device (171a). The wireless communication device 172 is composed of Bluetooth and Wi-Fi (not shown).

In the diagnosis process, the mouthpiece 127 is inserted into the aerobic induction conduit 126a, the operation button of the switch unit 191 is pressed, and the breath is blown into the mouthpiece 127. Then, the exhalation 1 is in contact with the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b of the sensor electrode 120a through the air induction pipe 126a.

When exhalation flows into the sensor electrode unit 120a, the controller 150 controls the operations of the light source 131, the first detector 110a, and the second detector 110b of the excitation energy supply unit 130. The value when the light source 131 is turned on and the value when the light source 131 is turned off are respectively detected.

The reason why the light source 131 detects the value when it is turned on and the value when it is turned off, is to correct an error from the value and to calculate the electron movement by pure memorized substance. That is, by subtracting the value detected when the light source 131 is turned on from the value detected when the light source 131 is turned off, various sources of error can be eliminated, and the error can be corrected to detect the movement of electrons through the memorized substance. From the presence or absence of the memorizing substance, the amount and the composition ratio of each memorizing substance can determine whether the cancer occurs, the type of cancer, and the progress of the cancer.

Example 7

Embodiment 7 of the present invention relates to a portable lung cancer diagnosis system using a smart phone, as shown in FIG. 46.

That is, a short range wireless communication network such as Bluetooth or Wi-Fi or GPS may be used for the portable lung cancer diagnosis system and the mobile phone, and the cancer diagnosis app is installed in the smartphone as in the fifth embodiment.

In this system, the mouthpiece 127 is inserted into the aerobic induction pipe 126a as in the sixth embodiment, the operation button of the switch unit 191 is pressed, and the breath is injected into the mouthpiece 127. Then, the exhalation 1 is in contact with the first positive electrode 121a, the negative electrode 124, and the second positive electrode 121b of the sensor electrode 120a through the air induction pipe 126a.

The detected value is transmitted to the smartphone and can be immediately confirmed by the user.

Example 8

This embodiment relates to a cancer diagnostic system.

The sensor electrode unit 120 described in the first to seventh embodiments, the excitation energy supply unit 130 and the exhalation collecting device 210 is configured to be connected to the sensor electrode unit. Here, the collecting device is similar to the collecting device of Example 3, but shows that it can be configured as a tube of a slightly slippery form.

In other words, the present embodiment will be described with reference to FIGS. 47 to 48, the switch unit 190 operated for diagnosing cancer, the sensor electrode unit 120 for detecting a cancer-causing substance, and the sensor electrode unit 120. An excitation energy supply unit 130 for supplying excitation energy to electrons, a detection unit 110 for detecting electron movement of the sensor electrode unit, a data storage unit 140 for storing information on the detection of the memorizing substance, Consists of a communication unit 170 for communicating with an external device and a control unit 150 for performing cancer diagnosis,

They are accommodated, and are comprised by the main body 200 which has a switch part and a detachable part in the upper surface, and a monitor, a display part provided in this main body.

The present invention of such a configuration is to diagnose the cancer by connecting the exhalation collected in the collecting device to the sensor electrode.

Example 9

The present invention relates to a cancer diagnosis system using big data, and in particular, to build a database by analyzing and processing a large amount of diagnostic data, and to analyze the cancer detection data requested by the client, cancer occurrence, cancer type, cancer progression degree This is to provide information about.

According to the technical idea of the present invention "cancer diagnosis system using big data", as shown in FIG.

A communication server performing communication;

A customer management server managing information about subscribers;

A database server for storing diagnostic data;

A backup server performing data backup;

A decision server having a level determining unit capable of determining a value level according to a predetermined decision criterion with respect to information transmitted from one server 12;

A filter module for classifying information of an information medium transmitted from the outside; And a main server for controlling the operation of each component. The diagnostic data transmitted from the cancer diagnosis system, which is a client system, is analyzed to calculate whether cancer is generated, the type, and the degree of progression.

The client cancer diagnosis system, which is a client system, is a system that detects a memorandum contained in exhalation or body fluid. The discovery of this memorandum means that there are cancer cells in the body.

Such a system is employed in any one of the system configuration, sensor electrode portion, and energy level design described in the above first to seventh embodiments.

The present invention is used in a molecular sensor, a sensor for diagnosing cancer using the molecular sensor, and a system for diagnosing cancer through the cancer diagnostic sensor provided with the cancer diagnostic sensor and collecting the breath.

Claims

A cathode configured to have a redox potential higher than the energy level of the valence band of the detection target material; And,

It includes; an anode configured to have a redox potential lower than the energy level of the valence band of the detection target material,

When the detection target material is introduced between the cathode and the anode, the molecular level sensor is characterized in that the energy level is set so that the electron movement from the cathode to the anode via the detection target material.
A cathode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential lower than the energy level of the conduction band of the detection target material; And,

And an excitation energy supply unit for supplying excitation energy to excite the electrons in the valence band of the detection target material to the conduction band.

When the detection target material flows between the cathode and the anode, the electrons in the valence band of the detection target material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction band are transferred to the anode. The molecular sensor is characterized in that the energy level is set to move the electrons from the cathode to the hole formed in the valence band of the detection target material.
A cathode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

The anode side is configured such that the energy level of the redox potential of the valence band is lower than that of the valence band of the substance to be detected, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Mobile derivatives; And,

And an excitation energy supply unit for supplying excitation energy to excite the electrons in the valence band of the anode-side movement inducing material to a conduction band.

When the detection target material flows between the cathode and the anode, the electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the cathode-side movement induction material The electrons excited by the conduction band move to the anode, the electrons of the detection target material move to the holes generated in the valence band of the anode-side transfer induction material, and the electrons move from the cathode to the holes generated in the valence band of the detection target material. Molecular sensor characterized in that the energy level is set to achieve the process.
A cathode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

Anode-side shifting where the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Inducer; And,

An excitation energy supply unit supplies excitation energy to excite the electrons in the valence band of the anode-side moving induction material to the conduction band, and supplies excitation energy to excite the electrons in the valence band of the detection target material into the conduction band. Including;

When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. Electrons excited by the conduction of the material move to the anode, and second, electrons in the valence band of the detection target material are excited by the excitation energy supplied from the excitation energy supply unit, and excitation according to the conduction of the detection target material The electrons move to the holes formed in the valence band of the anode-side moving induction material, and third, the energy level is set so that the electrons move from the cathode to the holes formed in the valence band of the detection target material. sensor.
A cathode configured to have a redox potential lower than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential lower than the energy level of the valence band of the detection target material;

The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And,

And an excitation energy supply unit for supplying excitation energy to excite the electrons in the valence band of the cathode-side movement inducing material to a conduction band.

When the detection target material is introduced between the cathode and the anode, first, electrons in the detection target material move to the anode, and second, the valence band of the cathode-side moving induction material is excited by the excitation energy supplied from the excitation energy supply unit. Electrons in the substrate are excited by the conduction band, and the electrons excited by the conduction band of the cathode-side transport inducing material move to the holes formed in the valence band of the detection target material, and third, the holes in the valence band of the cathode-side transport inductive material Molecular sensor, characterized in that the energy level is set so that the process of electrons in the cathode is made.
A cathode configured to have a redox potential lower than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential lower than the energy level of the conduction band of the detection target material;

The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And,

An excitation energy supply unit supplies excitation energy to excite the electrons in the valence band of the cathode-side moving induction material to the conduction band, and supplies excitation energy to excite the electrons in the valence band of the detection target material into the conduction band. Including;

When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the detection target material are excited by the excitation energy supplied from the excitation energy supply unit, and the excitation zone is excited by the conduction band of the detection target material. Electrons are moved to the anode, and second, the electrons in the valence band of the cathode-side mobile induction material are excited by the excitation energy supplied from the excitation energy supply unit, and are excited to the conduction band of the cathode-side mobile induction material. The molecular sensor is characterized in that the energy level is set so that the electron moves to the hole formed in the valence band of the detection target material, and third, the electron moves from the cathode to the hole formed in the valence band of the cathode-side moving induction material. .
A cathode configured to have a redox potential lower than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

The anode side is configured such that the energy level of the redox potential of the valence band is lower than that of the valence band of the substance to be detected, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Mobile derivatives;

The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And,

Excitation energy to supply electrons in the valence band of the cathode-side mobile induction material to excite the conduction band and excitation energy to supply electrons in the valence band of the cathode-side mobile induction material to the conduction band Including an energy supply unit,

When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. The electrons excited by the conduction of the material move to the anode, and second, the electrons of the detection target material move to the holes generated in the valence band of the anode-side moving induction material, and third, by the excitation energy supplied from the excitation energy supply unit. The electrons in the valence band of the cathode-side transfer inducing material are excited by the conduction band, and the electrons excited in the conduction band of the cathode-side transfer inducing material move to the holes generated in the valence band of the detection target material. Fourth, the cathode side The energy level is set so that electrons move from the cathode to the hole formed in the valence band of the mobile inductive material. Molecular sensor, characterized.
A cathode configured to have a redox potential lower than the energy level of the valence band of the detection target material;

An anode configured to have a redox potential higher than the energy level of the valence band of the detection target material;

Anode-side shifting where the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox level of the anode. Inducer;

The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and that the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the detection target material. Mobile derivatives; And,

Supply excitation energy to excite the electrons in the valence band of the anode-side mobile induction material to the conduction band, supply excitation energy to excite the electrons in the valence band of the cathode-side mobile induction material to the conduction band, And an excitation energy supply unit for supplying excitation energy to excite the electrons in the valence band of the detection target material to the conduction band.

When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. Electrons excited by the conduction of the material move to the anode, and second, electrons in the valence band of the detection target material are excited by the excitation energy supplied from the excitation energy supply unit, and excitation according to the conduction of the detection target material Electrons in the valence band of the cathode-side movement inducing material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons in the valence band of the anode-side movement inducing material are excited as conduction bands. Electrons excited by the conduction band of the cathode-side transfer inducing material are holes generated in the valence band of the detection target material. Fourth, the molecular sensor, characterized in that the energy level is set so that the process of the electrons from the cathode to the hole formed in the valence band of the cathode-side movement inducing material.
The molecular sensor according to claim 1, wherein the detection target material is nitrogen oxide (NOx) or a substance having radicals in a natural state.
The method according to any one of claims 3 to 4 or 7 to 8, wherein the anode-side movement inducing substance which induces the movement of donated electrons to the anode is composed of one or more. Molecular sensor characterized by.
The method of claim 10, wherein when the anode-side movement inducing substance is composed of a plurality of

The energy level of the conduction band of the first anode-side mobile induction material that receives electrons from the detection target material is set higher than the energy level of the valence band of the next anode-side mobile induction material,

The energy level of the conduction band of the last anode-side inductive material that donates electrons to the anode is set higher than that of the anode.

The energy level of the anode-side mobile induction material in the middle stage is set to the energy level of the conduction band higher than that of the valence band of the anode-side mobile induction material in the next stage, and the energy level of the valence band is set to the previous stage. Molecular sensor characterized in that the lower than the energy level of the conduction band of the anode-side moving induction material.
The molecular sensor according to any one of claims 5 to 8, wherein the cathode-side movement inducing substance which induces the movement of the electrons donated from the cathode to the substance to be detected is composed of one or more.
The method of claim 12, wherein when the cathode-side movement inducing substance is composed of a plurality of

The energy level of the conduction band of the first cathode-side mobile induction material receiving electrons from the cathode is set higher than the energy level of the valence band of the next cathode-side mobile induction material,

The energy level of the conduction band of the last cathode-side mobile inductive material that contributes electrons to the hole generated in the valence band of the detection target material is set higher than the energy level of the valence band of the detection target material.

The energy level of the cathode-side mobile induction material in the middle stage is set to the energy level of the conduction band higher than the energy level of the valence band of the cathode-side mobile induction material in the next stage, and the energy level of the valence band is set to the previous stage. Molecular sensor, characterized in that the lower than the energy level of the conduction band of the cathode-side moving induction material.
9. The excitation energy supply unit according to claim 2, wherein the excitation energy supply unit supplies an optical energy supply unit supplying optical energy equal to or greater than the bandgap energy between the valence band and the conduction band, or an electromagnetic energy supply unit supplying electromagnetic wave energy, or thermal energy. Molecular sensor, characterized in that consisting of any one or more of the heat energy supply.
The molecular sensor of claim 14, wherein the optical energy supply unit supplies one or more optical energy having different wavelengths and brightnesses.
15. The molecular sensor according to claim 14, wherein the light source of the light energy supply unit comprises at least one of an LED light source having different wavelengths, a laser light source having different wavelengths, or a halogen lamp.
15. The molecular sensor according to claim 14, wherein the electromagnetic wave energy supply unit supplies one or more electromagnetic energy with different wavelengths and intensities.
15. The molecular sensor of claim 14, wherein the thermal energy supply unit supplies one or more thermal energy having different temperatures.
The method of any one of claims 3 to 4 or 7 to 8, wherein the positive electrode-side transfer inducing substance is a fullerene, a fullerene salt, an iontofullerene, a pigment, or a complex of an iontofullerene and a pigment. Molecular sensor, characterized in that composed of any one or more of.
The molecular sensor according to claim 19, wherein the fullerene is any one of C60, C70, C72, C78, C82, C90, C94, and C96.
20. The molecular sensor according to claim 19, wherein the ions contained in the iontophorus fullerene are any one of lithium, sodium, potassium, cesium, magnesium, calcium, and strontium.
The method of claim 19, wherein the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, A molecular sensor characterized in that at least one of a polymer polymer or derivatives thereof, such as MDMO-PPV, MEH-PPV.
The method of claim 5, wherein the cathode-side movement inducing substance, characterized in that composed of any one or more of fullerenes, fullerene salts, ion-containing fullerenes, pigments, or complexes of ion-containing fullerenes and pigments. Molecular sensor.
The molecular sensor according to claim 23, wherein the fullerene is any one of C60, C70, C72, C78, C82, C90, C94, and C96.
24. The molecular sensor according to claim 23, wherein the ion contained in the iontophorus fullerene is any one of lithium, sodium, potassium, cesium, magnesium, calcium, and strontium.
The method of claim 23, wherein the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, A molecular sensor characterized in that at least one of a polymer polymer or derivatives thereof, such as MDMO-PPV, MEH-PPV.
The molecular sensor according to any one of claims 3 to 4 or 7 to 8, wherein the anode-side movement inducing substance is included in the anode using electrophoresis.
The molecular sensor according to any one of claims 5 to 8, wherein the cathode-side movement inducing substance is included in the cathode by using electrophoresis.
The molecular sensor according to any one of claims 1 to 8, further comprising a detection unit for detecting the flow of electrons according to the detection target material.
30. The molecular sensor according to claim 29, further comprising a display unit for displaying information on the detection of the detection target substance.
30. The molecular sensor according to claim 29, further comprising a communication unit which transmits information on the detection of the detection target substance to the outside.
30. The molecular sensor according to claim 29, further comprising a data storage unit for storing information on the detection of the detection target substance.
The molecular sensor according to any one of claims 1 to 8, wherein the cathode or anode comprises a transparent electrode.
34. The molecular sensor according to claim 33, wherein the transparent electrode is made of at least one of FTO, ITO, AZO, GZO, and TCO.
The cancer diagnosis system according to any one of claims 1 to 8, wherein the detection target material is a memorandum.
36. The cancer diagnosis system according to claim 35, wherein the memorizing substance is a substance having radicals in its natural state.
The method according to any one of claims 1 to 8, wherein the detection target substance is a memorizing substance, and the memorizing substance is toluene, 2,6-diisopropyl phenol (2,6-Diisopropylphenol), Cancer diagnosis system, characterized in that any one or more of 2-methylpyrazine (cyclomethylazine), cyclohexanone (Cyclohexanone).
9. The cancer diagnosis system according to any one of claims 1 to 8, wherein the type of cancer is determined by calculating a ratio of two or more detection target substances.
36. The cancer diagnostic system using energy level according to claim 35, wherein the amount of the memorandum is detected to determine the progress of cancer.
A sensor electrode part in which an energy level of a redox potential is set to move electrons from a cathode to an anode through a memorandum included in the expiratory phase;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A control unit connected between the sensor electrode unit, the detection unit, and the display unit; And,

And a power supply unit supplying operation power to each of the components.

Cancer diagnosis system, characterized in that the detection of the memorizing substance in the exhalation flows into the sensor electrode.
A sensor electrode part in which an energy level of a redox potential is set to move electrons from a cathode to an anode through a memorandum included in the expiratory phase;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, and the display unit; And,

And a power supply unit supplying operation power to each of the components.

Cancer diagnosis system, characterized in that the detection of the memorizing substance in the exhalation flows into the sensor electrode.
A sensor electrode part in which an energy level of a redox potential is set to move electrons from a cathode to an anode through a memorandum included in the expiratory phase;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A data storage unit for storing information on the memorized substance detection;

A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, and the data storage unit; And,

And a power supply unit supplying operation power to each of the components.

Cancer diagnosis system, characterized in that the detection of the memorizing substance in the exhalation flows into the sensor electrode.
A sensor electrode part in which an energy level of a redox potential is set to move electrons from a cathode to an anode through a memorandum included in the expiratory phase;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A data storage unit for storing information on the memorized substance detection;

A communication unit for exchanging information about the memorizing substance detection with an external device;

A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, the data storage unit, and the communication unit; And,

And a power supply unit supplying operation power to each of the components.

Cancer diagnosis system, characterized in that the detection of the memorizing substance in the exhalation flows into the sensor electrode.
44. The method of any one of claims 40 to 43, wherein the memorizing agent is toluene, 2,6-diisopropylphenol, 2-methylpyrazine, Cancer diagnostic system, characterized in that any one or more of cyclohexanone.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential higher than the energy level of the valence band of the memorandous substance contained in the expiratory phase; And,

It comprises; a positive electrode configured to have a redox potential lower than the energy level of the conduction band of the memorized material

When the memorized material is introduced between the cathode and the anode, the electrons in the valence band of the memorized material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction band move to the anode. Cancer energy system, characterized in that the energy level is set so that the process of moving electrons from the cathode to the hole formed in the valence band of the memorandous material.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential higher than the energy level of the valence band of the memorandous substance contained in the expiratory phase;

An anode configured to have a redox potential higher than the energy level of the valence band of the dark base material; And,

The anode side movement is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the memorized material, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. Inducer; consisting of,

When the memorizing material flows between the cathode and the anode, the electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the conduction band of the anode-side induction material is excited. The electrons excited to move to the anode, the electrons in the valence band of the memorized material move to the hole formed in the valence band of the anode-side moving induction material, and the electrons move from the cathode to the holes generated in the valence band of the memorized material. Cancer diagnosis system, characterized in that the energy level is set so that the process.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential higher than the energy level of the valence band of the memorandous substance contained in the expiratory phase;

An anode configured to have a redox potential higher than the energy level of the valence band of the dark base material; And,

The anode-side movement induction is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the memorized material, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. Including substance;

When the memorizing material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction material is excited. The electrons excited by the conduction of are moved to the anode, and second, the electrons in the valence band of the memorized material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction of the memorized material are And an energy level is set to move the electrons from the cathode to the holes formed in the valence band of the anode-side moving induction material.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential lower than the energy level of the valence band of the memorizing substance contained in the expiratory phase;

An anode configured to have a redox potential lower than the energy level of the valence band of the dark base material; And,

The cathode side movement is configured such that the energy level of the redox potential of the valence band is lower than that of the cathode and the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the memorized material. Inducer; consisting of,

When the memorizing material is introduced between the cathode and the anode, first, electrons in the memorizing material move to the anode, and second, the excitation energy supplied from the excitation energy supply unit is applied to the valence band of the cathode-side moving induction material. Electrons excited by the conduction band, and electrons excited by the conduction band of the cathode-side moving induction material move to the hole formed in the valence band of the memorizing material, and thirdly, the hole formed in the valence band of the cathode-side moving induction material Cancer diagnosis system, characterized in that the energy level is set so that the process of the electron movement.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential lower than the energy level of the valence band of the memorizing substance contained in the expiratory phase;

An anode configured to have a redox potential lower than the energy level of the conduction band of the memorizing material; And,

The cathode side movement is configured such that the energy level of the redox potential of the valence band is lower than that of the cathode and the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the memorized material. Inducer; consisting of,

When the memorized material is introduced between the cathode and the anode, first, electrons in the valence band of the memorized material are excited by the excitation energy supplied from the excitation energy supply unit, and electrons excited by the conduction of the memorized material are The electrons in the valence band of the cathode-side mobile induction material are excited to the conduction band, and the electrons excited in the conduction band of the cathode-side mobile induction material are memorized by excitation energy supplied from the excitation energy supply unit. A cancer diagnosis system, characterized in that the energy level is set to move to the hole formed in the valence band of the phosphorus material, and third, the electron is moved from the cathode to the hole formed in the valence band of the cathode-side movement inducing material.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential lower than the energy level of the valence band of the memorizing substance contained in the expiratory phase;

An anode configured to have a redox potential higher than the energy level of the valence band of the dark base material;

The anode side movement is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the memorized material, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. Inducer; And,

The cathode side movement is configured such that the energy level of the redox potential of the valence band is lower than that of the cathode and the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the memorized material. Inducer; consisting of,

When the memorizing material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. The electrons excited by the conduction of the material move to the anode, and second, the electrons in the valence band of the memorized material move to the holes generated in the valence band of the anode-side moving induction material, and third, the excitation supplied from the excitation energy supply unit. The electrons in the valence band of the cathode-side transfer inducing substance are excited by conduction bands by energy, and the electrons excited in the conduction band of the cathode-side transfer induction substance move to holes formed in the valence band of the memorized substance. Holes in the valence band of the cathode-side transfer inducing material are used to move the energy from the cathode to the energy level. Cancer diagnosis system, characterized in that is set.
The method according to any one of claims 40 to 43, wherein the sensor electrode unit,

A negative electrode configured to have a redox potential lower than the energy level of the valence band of the memorizing substance contained in the expiratory phase;

An anode configured to have a redox potential higher than the energy level of the valence band of the dark base material;

The anode-side movement induction is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the memorized material, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. matter; And,

The cathode side movement is configured such that the energy level of the redox potential of the valence band is lower than that of the cathode and the energy level of the redox potential of the conduction band has a higher energy level than that of the valence band of the memorized material. Inducer; consisting of,

When the memorizing material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. Electrons excited by the conduction of the material move to the anode, and second, electrons in the valence band of the memorized material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction of the memorized material Is moved to the positive hole formed in the valence band of the anode-side moving induction material, and third, the electrons in the valence band of the cathode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the cathode side The electrons excited by the conduction material of the mobile induction material move to the hole formed in the valence band of the memorizing material. Fourth, the cancer diagnosis system, characterized in that the energy level is set so that the process of moving the electrons from the cathode to the hole formed in the valence band of the cathode-side movement inducing material.
44. The method according to any one of claims 40 to 43, wherein the energy level of the redox potential is set so that the electrons are moved from the cathode to the anode via the electrons donated by the memorizing material in the sensor electrode. In the case of constructing a plurality of anode-side movement inducing materials that induce the movement of donor electrons to the anode,

The energy level of the conduction band of the first anode-side mobile induction material receiving electrons from the memorization material is set higher than the energy level of the valence band of the next anode-side mobile induction material,

The energy level of the conduction band of the last anode-side inductive material that donates electrons to the anode is set higher than that of the anode.

The energy level of the anode-side mobile induction material in the middle stage is set to the energy level of the conduction band higher than that of the valence band of the anode-side mobile induction material in the next stage, and the energy level of the valence band is set to the previous stage. Cancer diagnosis system, characterized in that the lower than the energy level of the conduction band of the anode-side mobile induction material.
44. The method according to any one of claims 40 to 43, wherein the energy level of the redox potential is set so that the electrons are moved from the cathode to the anode via the electrons donated by the memorizing material in the sensor electrode. In the case of constituting a plurality of cathode-side movement inducing substances which induce the movement of donated electrons from the cathode to the memorizing substance,

The energy level of the conduction band of the first cathode-side mobile induction material receiving electrons from the cathode is set higher than the energy level of the valence band of the next cathode-side mobile induction material,

The energy level of the conduction band of the last cathode-side mobile inductive material that contributes electrons to the hole formed in the valence band of the memorized substance is set higher than the energy level of the valence band of the memorized substance.

The energy level of the cathode-side mobile induction material in the middle stage is set to the energy level of the conduction band higher than the energy level of the valence band of the cathode-side mobile induction material in the next stage, and the energy level of the valence band is set to the previous stage. Cancer diagnosis system, characterized in that the lower than the energy level of the conduction band of the cathode-side moving induction material.
44. The method according to any one of claims 40 to 43, wherein the energy level of the redox potential is set so that the electrons are moved from the cathode to the anode via the electrons donated by the memorizing material in the sensor electrode. When the energy level is set using an anode-side movement inducing material that induces movement of donor electrons from a memorandum to the anode, or a cathode-side movement inducing material that induces movement of donated electrons from the memorization material. , The positive electrode side movement inducing material, or the negative electrode side movement inducing material,

Cancer diagnosis system, characterized in that it is composed of any one or more of fullerenes, fullerene salts, ion-containing fullerenes, pigments, or a complex of ion-containing fullerenes and pigments.
A sensor electrode part in which an energy level of a redox potential is set to move electrons from the cathode to the anode via a memorandum included in the body fluid;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A data storage unit for storing information on the memorized substance detection;

Communication unit for exchanging information on the memorized substance detection with an external device;

A switch unit comprising one or more switches;

A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, the data storage unit, the communication unit, and the switch unit; And,

And a power supply unit supplying operation power to each of the components.

Portable cancer diagnosis device using the energy level, characterized in that the detection of the memorizing substance in the body fluid flowing into the sensor electrode.
The method of claim 55, wherein the control unit,

And detecting the value of the sensor electrode portion before supplying the excitation energy, and correcting the value of the sensor electrode portion detected after the excitation energy is supplied.
The method of claim 55, wherein the control unit,

Portable cancer diagnosis device using the energy level, characterized in that to reset the sensor electrode by reversing the polarity of the power supplied to the sensor electrode.
A sensor electrode part in which an energy level of a redox potential is set to move electrons from a cathode to an anode through a memorandum included in the expiratory phase;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A data storage unit for storing information on the memorized substance detection;

Communication unit for exchanging information on the memorized substance detection with an external device;

A switch unit comprising one or more switches;

A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, the data storage unit, the communication unit, and the switch unit;

A power supply unit supplying operation power to each of the components; And,

The sensor electrode unit having the aerobic induction pipe and the aerobic outflow pipe inserted into the left and right penetrates the inside, and the excitation energy supply unit, the detection unit, the display unit, the data storage unit, the communication unit, the switch unit, the control unit, and the power supply Portable cancer diagnostic device using the exhalation, characterized in that it comprises a body;
A portable detection device for detecting the memorandum by setting the energy level of the redox potential so that electrons are moved from the cathode to the anode through the memorandum included in the expiratory phase;

A cancer diagnosis app indicating the presence of cancer memorandum and cancer occurrence by comparing and analyzing the measured values measured by the portable detection device; And,

The cancer diagnosis app is installed, the portable cancer diagnosis system using a smart phone, characterized in that it comprises a; smart communication to communicate with the portable detection device.
60. The method of claim 59, wherein the cancer diagnostic app,

Judging the presence of cancer by the presence or absence of a memorandum,

Portable cancer diagnosis system using a smartphone, characterized in that the judging of the cancer progression by the amount of memorandum.
60. The method of claim 59, wherein the cancer diagnostic app,

Portable lung cancer diagnostic system using a smart phone, characterized in that to determine the type of cancer by calculating the ratio of two or more memorandum.
60. The method of claim 59, wherein the memorizing substance is toluene (Toluene), 2,6-diisopropyl phenol (2,6-Diisopropylphenol), 2-methylpyrazine (2-Methylpyrazine), cyclohexanone (Cyclohexanone), 2 -Portable cancer diagnosis system using a smartphone, characterized in that any one or more of butanone, acetic acid, acetone, acetonitrile.
60. The method of claim 59, wherein the portable detection device,

A sensor electrode part in which an energy level of a redox potential is set to move electrons from a cathode to an anode through a memorandum included in the expiratory phase;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A display unit which displays information on the memorized substance detection;

A data storage unit for storing information on the memorized substance detection;

Communication unit for exchanging information on the memorized substance detection with an external device;

A switch unit comprising one or more switches;

A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, the data storage unit, the communication unit, and the switch unit;

A power supply unit supplying operation power to each of the components; And,

A sensor electrode unit having an aerobic induction pipe and an aerobic outflow pipe inserted into the left and right penetrates the inside thereof, wherein the excitation energy supply unit, the detection unit, the display unit, the data storage unit, the communication unit, the switch unit, the control unit, and the power supply Portable arm diagnosis system using a smart phone, characterized in that it comprises a body;
60. The method of claim 59, wherein the sensor electrode unit,

By designing the energy level of the redox potential to move the electron from the cathode to the anode through the electrons donated by the memorandum, there are a number of mechanisms that allow the movement of the electrons. Portable cancer diagnostic system using a smartphone, characterized in that configured to.
main body;

A switch unit installed at the main body and operated for diagnosing cancer;

A sensor electrode unit installed at the main body to allow the collecting device to be attached and detached and to detect a memorizing substance;

An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;

A detector for detecting electron movement of the sensor electrode unit;

A data storage unit for storing information on the memorized substance detection;

Communication unit for communicating with an external device

Cancer diagnosis system, characterized in that consisting of a control unit for performing cancer diagnosis.
A communication server performing communication;

A customer management server managing information about subscribers;

A database server for storing diagnostic data;

A backup server performing data backup;

A decision server having a level determining unit capable of determining a value level in accordance with a predetermined decision criterion with respect to information transmitted from one server;

A filter module for classifying information of an information medium transmitted from the outside; And a main server controlling the operation of each component; and analyzing the diagnostic data transmitted from each of the client systems, the cancer diagnosis system, to calculate whether cancer is generated, the type, and the degree of progress. Cancer diagnosis system using data.
The cancer diagnostic system according to claim 66, wherein the memorizing material is characterized by analyzing quantum yields according to wavelengths.