WO2019045503A1

WO2019045503A1 - Insertion guide needle integrated with blood glucose measurement sensor of carbon nanotube structure

Info

Publication number: WO2019045503A1
Application number: PCT/KR2018/010095
Authority: WO
Inventors: 최규동
Original assignee: 최규동
Priority date: 2017-09-01
Filing date: 2018-08-30
Publication date: 2019-03-07
Also published as: KR20190025208A

Abstract

The present invention relates to an insertion guide needle integrated with a blood glucose measurement sensor of a carbon nanotube structure. More particularly, the present invention relates to an insertion guide needle (100) integrated with a blood glucose measurement sensor of a carbon nanotube structure, comprising: a carbon nanotube blood glucose measurement sensor (110) composed of a carbon nanotube; a carbon nanotube insertion guide needle (120) having a sharp infiltration tip (121) formed at the end of an infiltration direction and having a sensor seating part (122) which is open on one side and on which the carbon nanotube blood glucose measurement sensor (110) can be seated; and a sensor-attached carbon fiber filament (130) connected to the carbon nanotube insertion guide needle (120) at an end of the infiltration direction and connected to the carbon nanotube blood glucose measurement sensor (110) at an opposite end of the infiltration direction.

Description

Carbon nanotube structure blood glucose measurement sensor integrated insertion guide needle

The present invention relates to an insertion guide needle integrated with a blood glucose measurement sensor of a carbon nanotube structure, comprising: a carbon nanotube blood glucose measurement sensor 110 composed of carbon nanotubes; And a sharpened tip portion 121 is formed at the end in the direction of the penetration and a carbon nanotube sensor 120 having one side opened and a sensor seating portion 122 on which the carbon nanotube blood glucose measurement sensor 110 is seated is formed, A tube insertion guide needle 120; And a sensor-bonded carbon fiber filament 130 connected to the carbon nanotube blood glucose measurement sensor 110. The sensor-bonded carbon fiber filament 130 is connected to the carbon nanotube insertion guide needle 120 at the infiltration direction side end, ; And an insertion guide needle 100 integrally formed with the blood glucose measurement sensor of the carbon nanotube structure.

In contrast, the glucose in the liver is converted into glucose, which flows into the blood to increase blood sugar. Therefore, the concentration of glucose in the blood is related to the diseases related to the metabolism such as diabetes, hyperglycemia due to diabetes, hypoglycemia, and measuring the glucose concentration is a very important means in the prevention, diagnosis and treatment of the diseases, In particular, if hypoglycemia occurs in a diabetic patient, it can lead to death due to shock, and blood glucose monitoring is very important for diabetic patients.

A biosensor employing an electrochemical method for measuring the concentration of glucose in the blood is a biosensor (for example, an antibody, an enzyme, an RNA, a DNA, etc.) having a specific recognition ability for a substance to be analyzed, The use of measurable compounds provides information on the presence and concentration of analytes.

Regarding such blood glucose measurement, conventionally, a user's blood is collected using a foot probe, and then transferred to a measurement strip to start a blood glucose measurement. The blood glucose level is measured by a continuous method such as Korean Patent No. 10-1512566 and a system capable of continuous glucose monitoring (CGM) have been proposed.

On the other hand, in order to perform continuous blood glucose monitoring, a probe type sensor for blood glucose measurement should be inserted into the human body. For this purpose, guides or guide needles have been used as disclosed in Korean Patent No. 10-1703948. The conventional guide or guide needle is mainly made of a metal material such as stainless steel and has a seating space 2 in which a probe type sensor can be seated as shown in Fig. And a connecting line passage opening 3 through which the connecting line can pass is formed in the longitudinal direction.

However, such conventional guide needles have a problem that it is very difficult to process the needles thinly, and that the number of work processes increases due to the post-processing such as the front face processing inserted into the human body after processing.

In addition, in order to insert a CGMS sensor into a human body using a conventional stainless steel needle, a separate rubber ring for binding a CGMS sensor and a stainless steel needle for inserting the human body should be provided. This rubber ring is not handled by the production facility, and most of the work is done manually by the hand of most people. Accordingly, it is very difficult to reduce the production cost of the CGMS sensor and the inserter (combination of sensor and guide needle).

On the other hand, the stainless steel guide needle is required to hold the CMGS sensor temporarily in the inside and to maintain a certain strength in order to be inserted into the human body. In order to do so, the thickness of the guide needle necessarily increases. Therefore, most of these conventional guide needles use very thick needles of about 28 gauge, so that there is a problem that when the CGMS sensor is inserted into the human body, it causes considerable pain.

SUMMARY OF THE INVENTION It is an object of the present invention to provide an insertion guide needle integrated with a blood glucose measurement sensor of a carbon nanotube structure having high strength and flexibility together with a simple process by solving the problems of the prior art.

In addition, a carbon nanotube structure blood glucose measurement sensor capable of precise measurement with a small diameter, and insert guide needles to be inserted into a human body by seating it can be inserted into a small diameter, thereby reducing the foreign body sensation or pain The problem is to be able to do.

The blood glucose measurement sensor and the insertion guide needle are connected to each other through the sensor binding fiber filaments. In the process of removing the guide needles, the sensor binding fiber filaments are cut off and separated from each other, So that the removal process can be performed.

In addition, in the case of moving in the direction of invasion, the load is transmitted from the guide needle oblique toothed protrusion portion to the sensor oblique serration protrusion, so that the blood glucose measuring sensor is efficiently infiltrated by the guide needle at the time of invasion, So that only the guide needle can be removed.

In order to accomplish the above object, a blood glucose measurement sensor integrated insertion guide needle having a carbon nanotube structure includes a carbon nanotube blood glucose measurement sensor 110 composed of carbon nanotubes; And a sharpened tip portion 121 is formed at the end in the direction of the penetration and a carbon nanotube sensor 120 having one side opened and a sensor seating portion 122 on which the carbon nanotube blood glucose measurement sensor 110 is seated is formed, A tube insertion guide needle 120; And a sensor-bonded carbon fiber filament 130 connected to the carbon nanotube blood glucose measurement sensor 110. The sensor-bonded carbon fiber filament 130 is connected to the carbon nanotube insertion guide needle 120 at the infiltration direction side end, ; And a control unit.

The carbon nanotube blood glucose measurement sensor 110 includes a carbon nanotube (CNT) 113 hybrid sensor electrode 112 on which boron doped diamond (BDD) 112 is fixed, .

Also, a sensor oblique serration protrusion 111 formed on a part of a side surface of the carbon nanotube blood glucose measurement sensor 110; Shaped protrusion 111 of the sensor when the carbon nanotube blood glucose measurement sensor 110 is seated in the sensor seating part 122. The sensing part 122 may be formed in a part of the sensor seating part 122, A guide needle oblique serration protrusion 125; And further comprising:

The sensor oblique saw tooth protrusion 111 and the guide needle oblique saw tooth protrusion 125 may protrude from the guide needle oblique saw tooth protrusion 125 when the carbon nanotube insertion guide needle 120 moves in the infiltration direction And the sensor is formed in a direction in which a load is transmitted to the oblique serration protrusion 111.

The infiltrating tip 121 may include a sensor end protector 123 formed to protect the carbon nanotube blood glucose measurement sensor 110 by surrounding the end portion of the carbon nanotube blood glucose measurement sensor 110 during the infiltration process. A sensor passage opening 124 formed to allow the carbon nanotube blood glucose measurement sensor 110 to exit when the carbon nanotube insertion guide needle 120 is removed after the invasion process; And further comprising:

According to the present invention, there is an advantage that it is possible to provide an insertion guide needle integrated with a blood glucose measurement sensor of a carbon nanotube structure having a high strength and flexibility together with a simple process by solving the problems of the conventional methods.

In addition, a carbon nanotube structure blood glucose measurement sensor capable of precise measurement with a small diameter, and insert guide needles to be inserted into a human body by seating it can be inserted into a small diameter, thereby reducing the foreign body sensation or pain It is possible to do so.

The blood glucose measurement sensor and the insertion guide needle are connected to each other through the sensor binding fiber filaments. In the process of removing the guide needles, the sensor binding fiber filaments are cut off and separated from each other, There is an advantage that it is possible to make the removal process possible.

1 shows a sensor insertion needle according to an embodiment of the present invention;

2 is a view showing a configuration of a single-unit insertion needle of a carbon nanotube structure according to an embodiment of the present invention.

3 is a view showing the structure of a carbon nanotube continuous blood glucose measurement sensor of an integrated insertion needle of a carbon nanotube structure sensor according to an embodiment of the present invention.

4 is a view showing an operation process of the integral insertion needle of the carbon nanotube structure according to the embodiment of the present invention.

Description of reference numerals used in drawings

100: Carbon nanotube structure blood glucose measurement sensor integrated insertion guide needle

110: Carbon nanotube blood sugar measurement sensor

111: sensor oblique serration protrusion

112: Boron doped diamond (BDD)

113: Carbon Nano Tube (CNT)

120: Carbon nanotube insertion guide needle

121: invasive tip portion 122: sensor seating portion

123: sensor end protecting portion 124: sensor passage opening

125: guide needle angular serration projection

130: Sensor-bonded carbon fiber filament

F: Breakage

S: skin

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, referring to the accompanying drawings, a carbon nanotube-structured sensor integrated insertion guide needle according to an embodiment of the present invention will be described in detail. First, it should be noted that, in the drawings, the same components or parts are denoted by the same reference numerals whenever possible. In describing the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

As shown in FIG. 2, the integrated insertion guide needle having a carbon nanotube structure according to an exemplary embodiment of the present invention includes a carbon nanotube blood glucose measurement sensor 110, a carbon nanotube insertion guide needle 120, And a binder carbon fiber filament 130.

The carbon nanotube blood glucose measurement sensor 110 is composed of carbon nanotubes as shown in FIG. 2, and is configured to measure blood glucose by being inserted into a human body. In this case, the carbon nanotube blood glucose measurement sensor 110 preferably includes carbon nanotubes (CNTs) on which boron-doped diamond (BDD) 112 as shown in FIG. Nano Tube (113) hybrid sensor electrode.

A carbon nanotube (CNT) hybrid sensor electrode having a boron-doped diamond (BDD) 112 fixed on the surface thereof is made of an amperometic glucose biosensor In one embodiment to be implemented, an enzyme for glucose measurement, such as glucose oxidase, is usually fixed between the porous sensor electrodes.

Diamond, which is a quaternary semiconductor element such as silicon, is an ultra-high-speed device material having a charge transfer speed of three times that of silicon and 4.5 times that of GaAs (gallium alsenide). The basic impedance of a sensor electrode made of gold or platinum The impedance of a carbon nanotube (CNT) hybrid sensor electrode structure in which boron doped diamond (BDD) 112 is fixed on the surface is in the range of 1,000 to 3,200 Ω, . Therefore, they have extremely sensitive and efficient detection characteristics.

On the other hand, since it has a much larger effective electrode area than a conventional carbon nanotube (CNT) single substance sensor or a boron doped diamond (BDD) sensor, an extremely excellent sensitivity and measurement limit . In addition, it has superior sensitivity and measurement limit compared to the existing electrodes of various other materials.

As described above, the carbon nanotube (CNT) hybrid sensor electrode on which the boron-doped diamond (BDD) is fixed on the surface has a high sensitivity and a minimum detection limit, It is possible to perform sufficient measurement even if the depth of the user's skin is invaded only by a depth of about 2 to 5 mm at a depth of 10 mm or more. In addition, by reducing the depth of the penetration, the capillary length of the probe sensor can be reduced. As a result, fast reaction time and short settling time can be expected. In addition, despite the shortened sensing time, More accurate measurement becomes possible.

In addition, due to the structure using a carbon nanotube (CNT: Carbon Nano Tube) whose diameter is extremely small (usually several tens of micrometers), the total diameter of the injection needle is hardly increased, and smooth invasion and scanning are possible .

Next, the carbon nanotube insertion guide needle 120 will be described. The carbon nanotube insertion guide needle 120 is formed of carbon nanotubes in the same manner as the carbon nanotube blood glucose measurement sensor 110. As shown in FIG. 2, at the distal end of the carbon nanotube insertion guide needle 120, And a sensor seating portion 122 is formed on one side of the sensor to allow the carbon nanotube blood glucose measurement sensor 110 to be placed thereon.

2, the infiltrating tip 121 may include a sensor end protector 123 formed to protect the end portion of the carbon nanotube blood glucose measurement sensor 110 in the infiltration direction during the infiltration process And the like. As shown in FIG. 2, when the carbon nanotube insertion guide needle 120 is removed after the infiltration process, the infiltrating tip 121 is moved to the carbon nanotube blood glucose measurement sensor 110 And a sensor passage opening (124) formed so as to protrude from the sensor opening (124).

The infiltrating tip 121 may have various shapes and sizes as required.

Next, the sensor-bonded carbon fiber filament 130 will be described. As shown in FIG. 2 and FIG. 4, the sensor-bonded carbon fiber filament 130 is connected to the carbon nanotube insertion guide needle 120 at the side in the infiltration direction, And is connected to the blood glucose measurement sensor 110.

In this case, the sensor-bonded carbon fiber filament 130 is formed of a carbon fiber material and has a filament shape. Therefore, the tensile strength of the sensor-bonded carbon fiber filament 130 is extremely high with respect to the force in the pulling direction, , It is easily broken or broken. 4 (A), when the carbon nanotube insertion guide needle 120 is inserted into the human body and inserted, the sensor-bonded carbon fiber filament 130 has a strong tensile strength, The carbon nanotube blood glucose measurement sensor 110 can be inserted into the human body together with the carbon nanotube insertion guide needle 120 because the carbon nanotube blood glucose measurement sensor 110 is pulled.

Meanwhile, as shown in FIG. 4 (B), in the process of removing and separating the carbon nanotube insertion guide needle 120, the carbon nanotube blood glucose measurement sensor 110 already inserted and the carbon nanotube The sensor binding carbon fiber filaments 130 connected between the tube insertion guide needles 120 exert mutual pressing forces at both ends. Therefore, the carbon nanotube blood glucose measurement sensor 110 may be broken down or broken (F) because the sensor-bonded carbon fiber filament 130 having a characteristic that the strength in the pushing direction is comparatively weak, And the carbon nanotube insertion guide needle 120 is released from the mechanical connection of the carbon nanotube insertion guide needle 120. Therefore, the carbon nanotube blood glucose measurement sensor 110 can be safely inserted into the human body, It becomes possible to remove it.

In this case, the force transmitted from the carbon nanotube insertion guide needle 120 to the carbon nanotube blood glucose measurement sensor 110 is not transmitted through only the sensor-bonded carbon fiber filament 130 during the invasion process It is desirable to be able to be delivered more efficiently. For this, as shown in FIG. 2, a sensor oblique serration protrusion 111 formed on a part of a side surface of the carbon nanotube blood glucose measurement sensor 110; Shaped protrusion 111 of the sensor when the carbon nanotube blood glucose measurement sensor 110 is seated in the sensor seating part 122. The sensing part 122 may be formed in a part of the sensor seating part 122, A guide needle oblique serration protrusion 125; And further comprising: As shown in FIGS. 2 and 4, the sensor oblique saw tooth protrusion 111 and the guide needle oblique saw tooth protrusion 125 move in a direction in which the carbon nanotube insertion guide needle 120 moves in the infiltration direction It is preferable that the guide needle is formed in a direction in which the load is transmitted from the oblique serration protrusion 125 to the sensor oblique serpentine protrusion 111.

The sensor oblique sawtooth protrusion 111 and the guide needle oblique sawtooth protrusion 125 of this structure are interlocked with the sensor-bonded carbon fiber filament 130, thereby enabling more effective transmission and release of the load. 4 (A), the sensor-bonded carbon fiber filament 130 is pulled so that the carbon nanotube blood glucose measurement sensor 110 and the carbon nanotube insertion The guide needles 120 are pulled in close contact with each other. Accordingly, the sensor oblique saw tooth protrusion 111 and the guide needle oblique saw tooth protrusion 125 are also in close contact with each other, so that the force to be infiltrated by the carbon nanotube insertion guide needle 120 can be more efficiently transferred to the carbon nano- And transmits it to the tube blood glucose measurement sensor 110.

Meanwhile, as shown in FIG. 4 (B), in the process of removing and separating the carbon nanotube insertion guide needle 120, the sensor-bonded carbon fiber filament 130 is cut and the carbon nanotube blood glucose measurement sensor 110 and the carbon nanotube insertion guide needle 120 are also loosened. Therefore, the sensor oblique toothed protrusion 111 and the guide needle oblique toothed protrusion 125, in addition to the direction of formation of the teeth of the sensor oblique toothed protrusion 111 and the guide needle oblique toothed protrusion 125, The carbon nanotube blood glucose measurement sensor 110 and the carbon nanotube insertion guide needle 120 can be more smoothly separated from each other.

Meanwhile, the carbon nanotube blood glucose measurement sensor 110, the carbon nanotube insertion guide needle 120, and the sensor-bonded carbon fiber filament 130 are all made of a carbon material such as carbon fiber It is possible. That is, the carbon fibers can be laminated in a predetermined shape, processed and bonded, and can be easily processed into a final shape through laser processing or etching. After that, it is preferable that the components including the carbon nanotube blood glucose measurement sensor 110 are coated with boron doped diamond (BDD) to have predetermined characteristics and strength. In this case, since the steel has a mechanical strength close to that of diamond in terms of strength, it can be manufactured to have sufficient strength even with an extremely small diameter.

Optimal embodiments have been disclosed in the drawings and specification. Although specific terms have been employed herein, they are used for purposes of illustration only and are not intended to limit the scope of the invention as defined in the claims or the claims. Therefore, those skilled in the art will appreciate that various modifications and equivalent embodiments are possible without departing from the scope of the present invention. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

Claims

A carbon nanotube blood glucose measuring sensor 110 composed of carbon nanotubes;

The carbon nanotube insertion portion 122 is formed at the distal end of the carbon nanotube blood glucose measurement sensor 110 and has a sharp penetrating tip portion 121 formed at the end of the carbon nanotube blood glucose measurement sensor 110, A guide needle 120;

A sensor-bonded carbon fiber filament 130 connected to the carbon nanotube insertion guide needle 120 at an infiltration direction side end and connected to the carbon nanotube blood glucose measurement sensor 110 at an opposite end side in the infiltration direction; And an insertion guide needle (100) integrally formed with the blood glucose measurement sensor of the carbon nanotube structure.
The method according to claim 1,

The carbon nanotube blood glucose measurement sensor 110 includes:

And a carbon nanotube (CNT) 113 hybrid sensor electrode on which boron doped diamond (BDD) 112 is fixed on the surface of the carbon nanotube structure. Integrated sensor insertion guide needle (100).
The method according to claim 1,

A sensor oblique serration protrusion 111 formed on a part of a side surface of the carbon nanotube blood glucose measurement sensor 110;

The sensor is formed in a part of the sensor seating part 122 and is configured to engage with the sensor oblique serration protrusion 111 when the carbon nanotube blood glucose measuring sensor 110 is seated on the sensor seating part 122. [ A needle-shaped serrated projection 125; And further comprising:

The sensor oblique saw tooth protrusion 111 and the guide needle oblique saw tooth protrusion 125 may protrude from the guide needle oblique saw tooth protrusion 125 when the carbon nanotube insertion guide needle 120 moves in the infiltration direction And the sensor is formed in a direction in which a load is transmitted to the oblique serration protrusion 111. The insertion guide needle 100 integrally formed with a blood glucose measurement sensor of the carbon nanotube structure.
The method according to any one of claims 1 to 3,

The infiltrating tip (121)

A sensor end protector 123 formed to surround and protect the end portion of the carbon nanotube blood glucose measurement sensor 110 during the invasion process;

A sensor passage opening 124 formed to allow the carbon nanotube blood glucose measurement sensor 110 to escape when the carbon nanotube insertion guide needle 120 is removed after the invasion process; (100) having a carbon nanotube structure integrated with a blood glucose measurement sensor.