WO2019010635A1 - Signal detector and signal detection method - Google Patents

Signal detector and signal detection method Download PDF

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Publication number
WO2019010635A1
WO2019010635A1 PCT/CN2017/092524 CN2017092524W WO2019010635A1 WO 2019010635 A1 WO2019010635 A1 WO 2019010635A1 CN 2017092524 W CN2017092524 W CN 2017092524W WO 2019010635 A1 WO2019010635 A1 WO 2019010635A1
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Prior art keywords
signal
electric field
skin
antenna
tested
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PCT/CN2017/092524
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French (fr)
Chinese (zh)
Inventor
刘振哲
李舟健
赵林
陈洋
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悦享趋势科技(北京)有限责任公司
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Priority to PCT/CN2017/092524 priority Critical patent/WO2019010635A1/en
Publication of WO2019010635A1 publication Critical patent/WO2019010635A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 

Definitions

  • the present invention relates to the field of signal processing, and in particular to a signal detector and a signal detecting method.
  • non-invasive human tissue physiological signal detection has a variety of technical approaches.
  • piezoelectric signal sensors In the field of cardiovascular parameter detection, piezoelectric signal sensors, electrocardiographic signals (ECG), photoplethysmography (PPG), and Impedance Cardiography (ICG) Doppler shift/phase shift signal sensors have achieved remarkable results, and many related products have been available.
  • ECG electrocardiographic signals
  • PPG photoplethysmography
  • ICG Impedance Cardiography
  • Extracting the physiological and pathological information of the human body from the pulse wave as the basis for clinical diagnosis and treatment has always been valued by the Chinese and foreign medical circles. Studies have shown that measuring pulse waves on human aortic vessels can yield more realistic and effective signals. However, because the aortic blood vessels are buried in the complex skin, fat, muscles, bones and other tissues of the human body, various detection techniques are brought tough challenges.
  • Piezoelectric signal sensors inevitably require the airbag to apply external pressure to compress the blood vessels to complete the blood pressure measurement. External pressure exerts adverse reactions such as emotional stress and discomfort, which affects the detection accuracy and experience; ECG signal sensor It is necessary to directly attach the metal electrode on the human skin, or at least touch the electrode with both hands; the photoelectric volume pulse wave signal sensor is currently only suitable for capillary measurement of the skin surface, the signal is extremely unstable, and is affected by the skin color; the bioimpedance signal sensor also needs The measuring electrode is attached around the heart; while the signal detected by the Doppler shift/phase shift detection mode is very weak, is susceptible to interference, and requires complicated signal processing, and the detection accuracy is low.
  • the signal input port is generally connected to the human body tissue to be tested, and the input signal and the output signal of the signal output port are measured by the corresponding measuring circuit, thereby obtaining the human body.
  • the tissue physiological activity signal increases the complexity of the measurement circuit because it needs to measure the incident signal and the reflected signal of the antenna input port at the same time.
  • another measurement method is: based on inductance or capacitance sensing, the parasitic capacitance or parasitic inductance generated by the human body changes with the pulse periodic pulse, thereby causing a change in the sensor resonance circuit parameter (resonance frequency).
  • the resonant circuit is required to have a higher intrinsic quality factor. Due to the high loss and high dielectric properties of human tissue itself, the resonant circuit is susceptible to great influence. The practical use of the sensor brings many difficulties and inconveniences.
  • the embodiment of the invention provides a signal detector and a signal detecting method, so as to at least solve the technical problems in the related art that when measuring the physiological activity of the tissue, the measurement is complicated and the use is inconvenient.
  • a signal detector includes: a radio frequency RF signal generator for generating an RF signal; and an RF antenna for exciting an alternating electric field according to the input RF signal, and Receiving an electric field disturbance signal; wherein the electric field disturbance signal is an alternating electric field is disturbed by a vibration signal of a surface of the skin to be tested, and an amplitude modulation signal generated by an amplitude of the vibration signal of the skin surface to be measured is modulated to an alternating electric field; amplitude modulation envelope detection And a signal for demodulating the surface of the skin to be tested from the electric field disturbance signal.
  • the signal detector further comprises: an RF output power amplifier for amplifying the RF signal generated by the RF RF signal generator and controlling the output power at -10 dBm to 20 dBm; and an RF output matching circuit for The output impedance of the RF signal is matched to the input impedance of the RF antenna; the RF input matching circuit is configured to perform maximum power transfer of the electric field disturbance signal received from the RF antenna.
  • the signal detector further includes: a first filter, configured to filter out an interference signal outside the working frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit; and a second filter, And filtering an interference signal out of a predetermined cutoff frequency of the vibration signal of the skin surface to be tested outputted from the amplitude modulation envelope detector according to a spectral characteristic of the vibration signal of the skin surface to be tested; a signal amplifier, Amplifying the demodulated vibration signal of the surface of the skin to be tested; an analog digital AD converter for converting the demodulated vibration signal of the surface of the skin to be tested into a digital signal; and a data signal processor Processing and displaying the digital signal.
  • a first filter configured to filter out an interference signal outside the working frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit
  • a second filter And filtering an interference signal out of a predetermined cutoff frequency of the vibration signal of the skin surface to be tested outputted from the amplitude modulation envelope detector
  • the RF antenna is one or more, the RF antenna supports transmission and reception sharing, or supports transmission and reception separation, wherein the RF antenna adopts an unbalanced feed.
  • the RF antenna is fabricated on a flexible circuit board FPC; or the RF antenna is fabricated on a flexible conductive braid, wherein the conductive yarn embroidering process or the conductive woven fabric is cut and pasted to make a close fit. On the clothes.
  • one or more coupling components are added within a predetermined distance around the RF antenna, and matching circuits corresponding to the one or more coupling components are used to change the electric field distribution of the RF antenna.
  • the coupling component is a metal structure
  • the shape of the coupling component is one of: a rectangular piece, a meander line, a deformation of a rectangular piece, a deformation of a meander line, wherein the coupling part and the RF antenna
  • the spacing between the two is adjustable; the corresponding matching circuit of the one or more coupling components is used to interconnect the corresponding coupling component and the circuit metal ground.
  • the signal detector further includes: an insulating isolation layer disposed between the RF antenna and the surface of the skin to be tested for isolating the air space.
  • the insulating isolation layer is made of medical silica gel, animal leather, and leather.
  • a signal detecting method comprising: generating an RF signal by using a radio frequency RF signal generator; exciting an alternating electric field according to the input RF signal by an RF antenna, and receiving an electric field disturbance signal
  • the electric field disturbance signal is that the alternating electric field is disturbed by the vibration signal of the surface of the skin to be tested, and the amplitude of the vibration signal of the skin surface to be tested is modulated to an amplitude modulation signal generated on the alternating electric field; the amplitude modulation envelope detector is used
  • the vibration signal of the surface of the skin to be tested is demodulated in the electric field disturbance signal.
  • the RF input matching circuit is used to receive the RF antenna The maximum power transmission of the electric field disturbance signal; and using a first filter to filter out an interference signal outside the working frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit; using amplitude modulation envelope detection
  • the second filter is used to filter out the amplitude modulation envelope detection according to the spectral characteristics of the vibration signal of the skin surface to be tested.
  • the vibration amplitude of the vibration signal of the skin surface to be tested is modulated to an electric field disturbance signal generated on the alternating electric field, and the vibration signal of the skin surface to be tested is demodulated from the electric field disturbance signal.
  • FIG. 1 is a schematic structural view of a signal detector according to an embodiment of the present invention.
  • FIG. 2 is a schematic diagram of an RF antenna of a wearable detector for detecting surface vibration of a human skin according to a first embodiment of the present invention
  • FIG. 3 is a schematic view of a wearable detector device for detecting surface vibration of a human skin according to a first embodiment of the present invention
  • FIG. 4 is a schematic view showing a result of detecting a skin surface vibration at a radial artery of a human body according to an embodiment of the present invention
  • Figure 5 is a schematic illustration of a wearable detector device for detecting surface vibration of a human skin in accordance with a second embodiment of the present invention
  • Figure 6 is a flow chart in accordance with a first embodiment of the present invention.
  • FIG. 1 is a schematic structural diagram of a signal detector according to an embodiment of the present invention. As shown in FIG. 1, the signal detector includes:
  • a radio frequency (Radio Frequency, RF for short) signal generator 11 for generating an RF signal can be used to generate a continuous wave RF signal, the signal frequency is in the RF antenna resonance frequency band; the RF antenna 12, and the RF signal generated above
  • the device 11 is connected to excite an alternating electric field according to the input RF signal and receive an electric field disturbance signal, wherein the electric field disturbance signal is an alternating electric field disturbed by a vibration signal of a surface of the skin to be tested, and the vibration of the surface of the skin to be tested
  • the amplitude of the signal is modulated to an amplitude modulated signal generated on the alternating electric field; an amplitude modulation envelope detector 13 is coupled to the RF antenna 12 for demodulating the vibration signal of the surface of the skin to be tested from the electric field disturbance signal.
  • an electric field disturbance signal generated by modulating the amplitude of the vibration signal on the surface of the skin to be measured to the alternating electric field is used, and the vibration signal of the surface of the skin to be tested is demodulated from the electric field disturbance signal to achieve
  • the purpose of directly measuring the physiological activities of the tissue is solved, and in the related art, when measuring the physiological activities of the tissue, there are technical problems of complicated measurement and inconvenient use.
  • the RF antenna can adopt an unbalanced feeding mode and operates in a near-field mode for generating an alternating oscillating electric field in a surface area of a human skin to be tested; the alternating electric field is disturbed by vibration of a human skin surface, thereby The skin surface vibration amplitude is modulated onto the alternating electric field to produce an amplitude modulated electric field disturbance signal.
  • the RF antenna may also be one or more, and the RF antenna may support transmission and reception sharing, and may also support transmission and reception separation. Therefore, it can be flexibly selected according to specific needs or design requirements.
  • the RF antenna can be preferentially fabricated on a flexible printed circuit (FPC) dielectric substrate, wherein the FPC dielectric substrate has a certain flexibility and can conform to the surface of the human tissue and is freely attached. Hehe.
  • FPC flexible printed circuit
  • the RF antenna can also be preferentially fabricated on a flexible metal braid, and is formed on the close-fitting clothing by a metal yarn embroidering process or a conductive cloth after cutting and pasting.
  • one or more coupling components and their corresponding matching circuits may be added within a predetermined distance around the RF antenna to change the electric field distribution in the vicinity of the RF antenna to obtain a maximum electric field strength in the target region; usually the predetermined distance is not A quarter wavelength greater than the operating frequency of the RF antenna, wherein the matching circuit is an interconnection between the coupling component and the circuit metal ground.
  • one or more metal structures may be added on both sides of the RF antenna as coupling members, and the metal structure may be a rectangular piece, a meander line or a deformation thereof.
  • the increased metal structure and the spacing between the antennas are adjustable. It is also possible to adjust the shape and spacing of the coupling components and their interconnection with the circuit metal to adjust the electric field strength and distribution on both sides of the antenna to improve the amplitude modulation effect of the skin surface vibration on the alternating electric field near the antenna.
  • the signal detector can also be provided with a duplexer, which is connected to the RF antenna for realizing the transceiving and sharing of the RF antenna.
  • an insulating isolation layer is disposed between the RF antenna and the surface of the skin to be tested; the RF antenna and the person There is a low dielectric loss, biocompatible insulating barrier between the skin surface.
  • the material of the insulating isolation layer may be medical silica gel, animal leather, leather.
  • the low dielectric loss insulating isolation layer may be made of medical silica gel, and the medical silicone injection molding the RF antenna through the slotting. Or ridged so that the medium between the barrier layer and the skin surface is air.
  • the insulating isolation layer may be made of animal skin and leather such as cowhide and sheepskin, and the RF antenna is skinned by the animal cortex, and the medium between the separation layer and the skin surface is air. .
  • the detector may further include an RF output power amplifier for amplifying the continuous wave RF signal and limiting the output power to -10 dBm to 20 dBm.
  • the detector may further include: an RF output matching circuit for matching an output impedance of the RF signal to an input impedance of the RF antenna, for example, an RF signal output by the RF signal source or the RF output power amplifier
  • the output impedance is matched to the input impedance of the RF antenna; the RF input matching circuit is used to perform maximum power transfer to the electric field disturbance signal received from the RF antenna. Achieve as much lossless transmission as possible of the RF signal.
  • the signal detector may further include: a first filter for filtering out the interference signal outside the working frequency band of the continuous wave RF signal.
  • the signal detector may further include: a second filter, configured to select a suitable cutoff frequency according to the spectral characteristics of the surface vibration signal of the human skin, and filter out other interference signals.
  • the signal detector further includes: a signal amplifier for demodulating the to-be-tested The vibration signal of the skin surface is amplified; an AD converter for converting the demodulated human skin surface vibration signal into a digital signal; and a digital signal processor for performing subsequent algorithm processing and display on the converted digital signal .
  • the detector provided by the above embodiment may be a wearable detector for detecting surface vibration of a human skin, which effectively solves the problem that the detector needs airbag pressure and direct skin when detecting the physiological tissue in the related art.
  • Contact susceptible to interference, low detection accuracy and other technical issues.
  • a signal detector is used as a wearable detector for detecting surface vibration of a human skin as an example.
  • the RF antenna includes:
  • the RF antenna radiator is a single radiator, using unbalanced feeding to improve the sky
  • the line is coupled to the electric field of the body tissue and contributes to the design of the coupling components around the antenna.
  • the coupling member 1 and the coupling member 2 are respectively distributed on both sides of the RF antenna radiator; the shape of the coupling member and the indirect adjustment of the RF antenna radiator.
  • the matching circuit 1 and the matching circuit 2 respectively connect the corresponding coupling components and realize different matching, thereby adjusting the electric field distribution and improving the amplitude modulation effect of the skin surface vibration.
  • the detector device includes:
  • RF antenna 12 which can be fed unbalanced and operates in near field mode.
  • the RF antenna 12 can be preferentially designed as a flexible antenna to be more easily attached to the human body; optionally, the RF antenna 12 is formed on the flexible FPC dielectric substrate by planar printing; alternatively, the RF antenna 12 is adopted.
  • the conductive yarn embroidering process or the conductive woven fabric is cut and pasted and made on the clothes worn by the body;
  • a duplexer 38 connected to the RF antenna to implement transceiver sharing of the RF antenna;
  • An insulating isolation layer 39 a biocompatible insulating isolation layer for a low dielectric loss between the RF antenna and the human skin surface;
  • the insulating isolation layer has a low dielectric loss, and the thickness should be as thin as possible, and it is recommended not to exceed 1 mm to reduce the loss of energy propagation in the medium.
  • the insulating insulation layer has good biocompatibility to ensure long-term contact with human skin.
  • the insulating layer also has good mechanical flexibility and can conform well to the skin of various parts of the human body, and should be introduced between the two. The air gap is to ensure that the insulating barrier does not oppress the surface vibration of the skin.
  • the low dielectric loss, biocompatible insulating isolation layer is made of medical silica gel.
  • the medical silicone injection molding RF antenna is used to form a medium between the separation layer and the skin surface by slotting or ribbing. For the air.
  • the low dielectric loss, biocompatible insulating insulation layer is made of animal skin and leather such as cowhide and sheepskin.
  • the RF antenna is skinned by animal leather and is isolated by slotting or ribbing.
  • the medium between the layer and the skin surface is air.
  • RF signal generator 11 generating a continuous wave RF signal, the signal frequency is within the resonant frequency band of the RF antenna;
  • RF output power amplifier 36 amplifying the continuous wave RF signal, the output power is limited to -10dBm to 20dBm;
  • An RF output matching circuit 37 matching the output impedance of the RF output power amplifier to the input impedance of the antenna in a maximum power matching manner;
  • An RF input matching circuit 35 matching the output impedance of the antenna to the next stage circuit in a maximum power matching manner;
  • a first filter 34 filtering out interference signals outside the working frequency band of the continuous wave RF signal
  • An amplitude modulation envelope detector 13 demodulating an amplitude modulated electric field disturbance signal carrying a skin surface vibration signal;
  • a second filter 33 according to the characteristics of the surface vibration signal of the human skin, selecting a suitable cutoff frequency to filter out other interference signals;
  • a signal amplifier 32 for amplifying the demodulated vibration signal of the surface of the skin to be tested;
  • the AD converter and the digital signal processor 31 convert the demodulated human skin surface vibration signal into a digital signal and perform subsequent algorithm processing.
  • FIG. 4 is a schematic diagram showing the detection result of the skin surface vibration at the radial artery of the human body according to an embodiment of the present invention.
  • the pulse signal waveform obtained by the wristband type watch test using the 418 MHz detection signal is as shown in FIG. 4, and the test result also shows: The peak amplitude is about 8520000, the trough amplitude is about 8350000, and the pulse wave state is continuous with time.
  • the test results show that the method for detecting surface vibration of human skin according to the embodiment of the present invention can be used and has good results.
  • FIG. 5 is a schematic diagram of a wearable detector device for detecting surface vibration of a human skin according to a second embodiment of the present invention. As shown in FIG. 5, this embodiment differs from FIG. 3 in that an amplitude modulation envelope detector is used. 13 is replaced with a mixer 51, and the signal amplifier 32 is omitted. The mixer 51 requires the RF signal generator 11 to provide an RF signal as a local oscillator signal for synchronous demodulation with the received signal after the first filter 34. This method can improve the conversion gain of the demodulation circuit and save the signal amplifier.
  • FIG. 6 is a flow chart according to the first embodiment of the present invention. As shown in FIG. 6, the method includes the following steps:
  • Step S101 placing the RF antenna on a skin surface of the human body having superficial vibration, such as a radial artery, a radial artery, a carotid artery, a subclavian artery, or the like;
  • Step S102 the RF signal generator generates a continuous wave RF signal, which is amplified by the RF output power amplifier, and connected to the antenna duplexer signal input terminal through the RF output matching circuit; at this time, the alternating oscillation is excited near the antenna.
  • the electric field; the alternating electric field is disturbed by the vibration of the surface of the human skin, thereby modulating the amplitude of the skin surface vibration to the alternating electric field, and generating an amplitude-modulated electric field disturbance signal;
  • Step S103 the electric field disturbance signal is detected by the RF antenna, and is connected to the RF input matching circuit through the duplexer output port;
  • Step S104 filtering the interference signal outside the working frequency band by the first filter, and demodulating the surface vibration signal of the human skin by the amplitude modulation envelope detector;
  • Step S105 the demodulated human skin surface vibration signal is filtered by the second filter, input to the digital signal processor for subsequent processing by AD conversion.
  • the disclosed technical contents may be implemented in other manners.
  • the device embodiments described above are only schematic.
  • the division of cells may be a logical function division.
  • multiple units or components may be combined or integrated into Another system, or some features can be ignored or not executed.
  • the mutual coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection through some interface, unit or module, and may be electrical or otherwise.
  • the units described as separate components may or may not be physically separate, and the components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of the embodiment.
  • each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit.
  • the above integrated unit can be implemented in the form of hardware or in the form of a software functional unit.
  • An integrated unit if implemented in the form of a software functional unit and sold or used as a standalone product, can be stored in a computer readable storage medium.
  • the technical solution of the present invention which is essential or contributes to the prior art, or all or part of the technical solution, may be embodied in the form of a software product stored in a storage medium.
  • a number of instructions are included to cause a computer device (which may be a personal computer, server or network device, etc.) to perform all or part of the steps of the various embodiments of the present invention.
  • the foregoing storage medium includes: a U disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a removable hard disk, a magnetic disk, or an optical disk, and the like. .

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Abstract

Provided are a signal detector and a signal detection method. The signal detector comprises: a radio frequency (RF) signal generator (11) for generating an RF signal; an RF antenna (12) for exciting an alternating electric field according to the input RF signal, and receiving an electric field disturbance signal, wherein the electric field disturbance signal is an amplitude modulation signal generated by means of the alternating electric field being disturbed by a vibration signal on a skin surface to be detected, and the amplitude of the vibration signal on the skin surface to be detected is modulated onto the alternating electric field; and an amplitude modulation envelope detector (13) for demodulating the vibration signal on the skin surface to be detected from the electric field disturbance signal. The technical problems in the related art of complex measurement and inconvenient use occurring when the physiological activities of tissues are measured are solved.

Description

信号探测器及信号探测方法Signal detector and signal detection method 技术领域Technical field
本发明涉及信号处理领域,具体而言,涉及一种信号探测器及信号探测方法。The present invention relates to the field of signal processing, and in particular to a signal detector and a signal detecting method.
背景技术Background technique
当前,非侵入式人体组织生理信号探测已有多种技术途径。在心血管状态参数检测领域,压电信号传感器、心电信号传感器(Electrocardiograph,简称为ECG)、光电容积脉搏波信号传感器(Photoplethysmography,简称为PPG)、生物阻抗信号传感器(Impedance Cardiography,简称为ICG)、多普勒频移/相移信号传感器等均取得了显著的研究成果,并有众多相关产品问世。At present, non-invasive human tissue physiological signal detection has a variety of technical approaches. In the field of cardiovascular parameter detection, piezoelectric signal sensors, electrocardiographic signals (ECG), photoplethysmography (PPG), and Impedance Cardiography (ICG) Doppler shift/phase shift signal sensors have achieved remarkable results, and many related products have been available.
从脉搏波中提取人体的生理病理信息作为临床诊断和治疗依据,历来都受到中外医学界的重视。研究表明,在人体主动脉血管上测量脉搏波能够获得更加真实有效的信号。但由于主动脉血管埋藏在人体复杂的皮肤、脂肪、肌肉、骨骼等组织中,给各项探测技术都带来严峻挑战。Extracting the physiological and pathological information of the human body from the pulse wave as the basis for clinical diagnosis and treatment has always been valued by the Chinese and foreign medical circles. Studies have shown that measuring pulse waves on human aortic vessels can yield more realistic and effective signals. However, because the aortic blood vessels are buried in the complex skin, fat, muscles, bones and other tissues of the human body, various detection techniques are brought tough challenges.
压电信号传感器不可避免的需要气囊施加外部压力以压迫血管来完成血压测量,外部施压往往会给人带来情绪紧张、感觉不适等不良反应,从而影响检测精度和使用体验;心电信号传感器需要在人体皮肤上直接贴金属电极片,或至少需要双手触摸电极;光电容积脉搏波信号传感器目前只适用于皮肤表面毛细血管测量,信号极不稳定,且受肤色影响;生物阻抗信号传感器同样需要在心脏四周粘贴测量电极;而多普勒频移/相移检测方式检测到的信号非常微弱,容易受到干扰,且需要复杂的信号处理,检测精度较低。Piezoelectric signal sensors inevitably require the airbag to apply external pressure to compress the blood vessels to complete the blood pressure measurement. External pressure exerts adverse reactions such as emotional stress and discomfort, which affects the detection accuracy and experience; ECG signal sensor It is necessary to directly attach the metal electrode on the human skin, or at least touch the electrode with both hands; the photoelectric volume pulse wave signal sensor is currently only suitable for capillary measurement of the skin surface, the signal is extremely unstable, and is affected by the skin color; the bioimpedance signal sensor also needs The measuring electrode is attached around the heart; while the signal detected by the Doppler shift/phase shift detection mode is very weak, is susceptible to interference, and requires complicated signal processing, and the detection accuracy is low.
在相关技术中,在对人体组织生理活动进行探测时,一般将信号输入口连接待测人体组织,通过对应的测量电路对输入的信号以及对信号输出口的输出信号进行测量,从而得到获得人体组织生理活动信号,由于需要同时对天线输入端口的入射信号和反射信号进行测量,增加了测量电路的复杂度。In the related art, when detecting physiological activities of human tissues, the signal input port is generally connected to the human body tissue to be tested, and the input signal and the output signal of the signal output port are measured by the corresponding measuring circuit, thereby obtaining the human body. The tissue physiological activity signal increases the complexity of the measurement circuit because it needs to measure the incident signal and the reflected signal of the antenna input port at the same time.
在相关技术中,另外一种测量方式是:基于电感或电容感测,人体组织产生的寄生电容或寄生电感随脉搏周期性的搏动而变化,从而引起传感器谐振电路参数(谐振频率)的变化。为了获得较高的探测灵敏度,要求该谐振电路具有较高的本征品质因数。由于人体组织本身具有的高损耗和高介电特性,该谐振电路很容易受到极大影响, 对传感器实际使用带来诸多困难和不便。In the related art, another measurement method is: based on inductance or capacitance sensing, the parasitic capacitance or parasitic inductance generated by the human body changes with the pulse periodic pulse, thereby causing a change in the sensor resonance circuit parameter (resonance frequency). In order to achieve higher detection sensitivity, the resonant circuit is required to have a higher intrinsic quality factor. Due to the high loss and high dielectric properties of human tissue itself, the resonant circuit is susceptible to great influence. The practical use of the sensor brings many difficulties and inconveniences.
因此,在相关技术中,对组织生理活动进行测量时,存在测量复杂,使用不便的问题。Therefore, in the related art, when measuring physiological activities of tissues, there is a problem that measurement is complicated and inconvenient to use.
针对上述的问题,目前尚未提出有效的解决方案。In response to the above problems, no effective solution has been proposed yet.
发明内容Summary of the invention
本发明实施例提供了一种信号探测器及信号探测方法,以至少解决相关技术中,对组织生理活动进行测量时,存在测量复杂,使用不便的技术问题。The embodiment of the invention provides a signal detector and a signal detecting method, so as to at least solve the technical problems in the related art that when measuring the physiological activity of the tissue, the measurement is complicated and the use is inconvenient.
根据本发明实施例的一个方面,提供了一种信号探测器,包括:射频RF信号发生器,用于产生RF信号;RF天线,用于根据输入的所述RF信号激励起交变电场,并接收电场扰动信号;其中,所述电场扰动信号为交变电场被待测皮肤表面的振动信号所扰动,待测皮肤表面的振动信号幅度调制到交变电场上产生的调幅信号;调幅包络检波器,用于从所述电场扰动信号中解调出所述待测皮肤表面的振动信号。According to an aspect of an embodiment of the present invention, a signal detector includes: a radio frequency RF signal generator for generating an RF signal; and an RF antenna for exciting an alternating electric field according to the input RF signal, and Receiving an electric field disturbance signal; wherein the electric field disturbance signal is an alternating electric field is disturbed by a vibration signal of a surface of the skin to be tested, and an amplitude modulation signal generated by an amplitude of the vibration signal of the skin surface to be measured is modulated to an alternating electric field; amplitude modulation envelope detection And a signal for demodulating the surface of the skin to be tested from the electric field disturbance signal.
可选地,该信号探测器还包括:RF输出功率放大器,用于放大所述射频RF信号发生器产生的RF信号,并控制输出功率在-10dBm至20dBm;RF输出匹配电路,用于将所述RF信号的输出阻抗匹配到RF天线的输入阻抗;RF输入匹配电路,用于完成对从所述RF天线接收的所述电场扰动信号的最大功率传输。Optionally, the signal detector further comprises: an RF output power amplifier for amplifying the RF signal generated by the RF RF signal generator and controlling the output power at -10 dBm to 20 dBm; and an RF output matching circuit for The output impedance of the RF signal is matched to the input impedance of the RF antenna; the RF input matching circuit is configured to perform maximum power transfer of the electric field disturbance signal received from the RF antenna.
可选地,该信号探测器还包括:第一滤波器,用于滤除从所述RF输入匹配电路输出的电场扰动信号中所述RF信号的工作频段外的干扰信号;第二滤波器,用于根据所述待测皮肤表面的振动信号的频谱特征,滤除从所述调幅包络检波器中输出的所述待测皮肤表面的振动信号中预定截止频率外的干扰信号;信号放大器,将解调出的所述待测皮肤表面的振动信号进行放大;模拟数字AD转换器,用于将解调出的所述待测皮肤表面的振动信号转换为数字信号;数据信号处理器,用于对所述数字信号进行处理和显示。Optionally, the signal detector further includes: a first filter, configured to filter out an interference signal outside the working frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit; and a second filter, And filtering an interference signal out of a predetermined cutoff frequency of the vibration signal of the skin surface to be tested outputted from the amplitude modulation envelope detector according to a spectral characteristic of the vibration signal of the skin surface to be tested; a signal amplifier, Amplifying the demodulated vibration signal of the surface of the skin to be tested; an analog digital AD converter for converting the demodulated vibration signal of the surface of the skin to be tested into a digital signal; and a data signal processor Processing and displaying the digital signal.
可选地,所述RF天线为一个或多个,所述RF天线支持收发共用,或者支持收发分离,其中,所述RF天线采用非平衡式馈电。Optionally, the RF antenna is one or more, the RF antenna supports transmission and reception sharing, or supports transmission and reception separation, wherein the RF antenna adopts an unbalanced feed.
可选地,所述RF天线制作在柔性电路板FPC上;或者,所述RF天线制作在柔性导电编织物上,其中,采用导电纱线刺绣工艺或导电织布裁剪后粘贴的方式制作在贴身衣物上。Optionally, the RF antenna is fabricated on a flexible circuit board FPC; or the RF antenna is fabricated on a flexible conductive braid, wherein the conductive yarn embroidering process or the conductive woven fabric is cut and pasted to make a close fit. On the clothes.
可选地,所述RF天线周边预定距离内增加有一个或多个耦合部件,以及所述一个或多个耦合部件对应的匹配电路,用于改变所述RF天线的电场分布。 Optionally, one or more coupling components are added within a predetermined distance around the RF antenna, and matching circuits corresponding to the one or more coupling components are used to change the electric field distribution of the RF antenna.
可选地,所述耦合部件为金属结构,所述耦合部件的形状为以下之一:矩形片、曲折线、矩形片的变形、曲折线的变形,其中,所述耦合部件与所述RF天线间的间距可调;所述一个或多个耦合部件对应的匹配电路用于互联对应的耦合部件和电路金属地。Optionally, the coupling component is a metal structure, and the shape of the coupling component is one of: a rectangular piece, a meander line, a deformation of a rectangular piece, a deformation of a meander line, wherein the coupling part and the RF antenna The spacing between the two is adjustable; the corresponding matching circuit of the one or more coupling components is used to interconnect the corresponding coupling component and the circuit metal ground.
可选地,该信号探测器还包括:绝缘隔离层,设置于所述RF天线与待测皮肤表面之间,用于隔离出空气间隔。Optionally, the signal detector further includes: an insulating isolation layer disposed between the RF antenna and the surface of the skin to be tested for isolating the air space.
可选地,所述绝缘隔离层的材质为医用硅胶、动物皮质、皮革。Optionally, the insulating isolation layer is made of medical silica gel, animal leather, and leather.
根据本发发明的另一个方面,提供了一种信号探测方法,包括:采用射频RF信号发生器产生RF信号;通过RF天线根据输入的所述RF信号激励起交变电场,并接收电场扰动信号;其中,所述电场扰动信号为交变电场被待测皮肤表面的振动信号所扰动,待测皮肤表面的振动信号幅度调制到交变电场上产生的调幅信号;采用调幅包络检波器从所述电场扰动信号中解调出所述待测皮肤表面的振动信号。According to another aspect of the present invention, a signal detecting method is provided, comprising: generating an RF signal by using a radio frequency RF signal generator; exciting an alternating electric field according to the input RF signal by an RF antenna, and receiving an electric field disturbance signal Wherein the electric field disturbance signal is that the alternating electric field is disturbed by the vibration signal of the surface of the skin to be tested, and the amplitude of the vibration signal of the skin surface to be tested is modulated to an amplitude modulation signal generated on the alternating electric field; the amplitude modulation envelope detector is used The vibration signal of the surface of the skin to be tested is demodulated in the electric field disturbance signal.
可选地,在采用所述RF信号发生器产生所述RF信号之后,采用RF输出功率放大器放大所述射频RF信号发生器产生的RF信号;并通过RF输出匹配电路将所述RF信号的输出阻抗匹配到RF天线的输入阻抗;在采用调幅包络检波器从所述电场扰动信号中解调出所述待测皮肤表面的振动信号之前,采用RF输入匹配电路完成对从所述RF天线接收的所述电场扰动信号的最大功率传输;以及采用第一滤波器滤除从所述RF输入匹配电路输出的电场扰动信号中所述RF信号的工作频段外的干扰信号;在采用调幅包络检波器从所述电场扰动信号中解调出所述待测皮肤表面的振动信号之后,采用第二滤波器根据所述待测皮肤表面的振动信号的频谱特征,滤除从所述调幅包络检波器中输出的所述待测皮肤表面的振动信号中预定截止频率外的干扰信号;通过信号放大器,将解调出的所述待测皮肤表面的振动信号进行放大;通过模拟数字AD转换器将解调出的所述待测皮肤表面的振动信号转换为数字信号;以及采用数据信号处理器对所述数字信号进行处理和显示。Optionally, after generating the RF signal by using the RF signal generator, amplifying the RF signal generated by the RF RF signal generator with an RF output power amplifier; and outputting the RF signal by an RF output matching circuit The impedance is matched to the input impedance of the RF antenna; before the vibration signal of the surface of the skin to be tested is demodulated from the electric field disturbance signal by using an amplitude modulation envelope detector, the RF input matching circuit is used to receive the RF antenna The maximum power transmission of the electric field disturbance signal; and using a first filter to filter out an interference signal outside the working frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit; using amplitude modulation envelope detection After demodulating the vibration signal of the surface of the skin to be tested from the electric field disturbance signal, the second filter is used to filter out the amplitude modulation envelope detection according to the spectral characteristics of the vibration signal of the skin surface to be tested. An interference signal outside the predetermined cutoff frequency of the vibration signal of the surface of the skin to be tested outputted in the device; the demodulated The skin surface of the vibration signals is amplified; by the analog-digital converter AD demodulated measured skin surface the vibration signal into a digital signal; and a data signal using the digital signal processor for processing and display.
在本发明实施例中,采用将待测皮肤表面的振动信号的振动幅度调制到交变电场上产生的电场扰动信号,并从该电场扰动信号中解调出待测皮肤表面的振动信号的方式,达到了直接测量组织生理活动的目的,进而解决了相关技术中,对组织生理活动进行测量时,存在测量复杂,使用不便的技术问题。In the embodiment of the present invention, the vibration amplitude of the vibration signal of the skin surface to be tested is modulated to an electric field disturbance signal generated on the alternating electric field, and the vibration signal of the skin surface to be tested is demodulated from the electric field disturbance signal. The purpose of directly measuring the physiological activities of the tissue is achieved, and the technical problems of complicated measurement and inconvenient use are also solved in the related art when measuring the physiological activities of the tissue.
附图说明DRAWINGS
此处所说明的附图用来提供对本发明的进一步理解,构成本申请的一部分,本发明的示意性实施例及其说明用于解释本发明,并不构成对本发明的不当限定。在附图 中:The drawings described herein are intended to provide a further understanding of the invention, and are intended to be a part of the invention. In the drawing in:
图1是根据本发明实施例的信号探测器的结构示意图;1 is a schematic structural view of a signal detector according to an embodiment of the present invention;
图2是根据本发明第一实施例的可穿戴式用于检测人体皮肤表面振动的探测器的RF天线的示意图;2 is a schematic diagram of an RF antenna of a wearable detector for detecting surface vibration of a human skin according to a first embodiment of the present invention;
图3是根据本发明第一实施例的可穿戴式用于检测人体皮肤表面振动的探测器装置的示意图;3 is a schematic view of a wearable detector device for detecting surface vibration of a human skin according to a first embodiment of the present invention;
图4是根据本发明实施例的人体桡动脉处皮肤表面振动的探测结果的示意图;4 is a schematic view showing a result of detecting a skin surface vibration at a radial artery of a human body according to an embodiment of the present invention;
图5是根据本发明第二实施例的可穿戴式用于检测人体皮肤表面振动的探测器装置的示意图;Figure 5 is a schematic illustration of a wearable detector device for detecting surface vibration of a human skin in accordance with a second embodiment of the present invention;
图6是根据本发明第一实施例的流程图。Figure 6 is a flow chart in accordance with a first embodiment of the present invention.
具体实施方式Detailed ways
为了使本技术领域的人员更好地理解本发明方案,下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分的实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都应当属于本发明保护的范围。The technical solutions in the embodiments of the present invention are clearly and completely described in the following with reference to the accompanying drawings in the embodiments of the present invention. It is an embodiment of the invention, but not all of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of the present invention.
需要说明的是,本发明的说明书和权利要求书及上述附图中的术语“第一”、“第二”等是用于区别类似的对象,而不必用于描述特定的顺序或先后次序。应该理解这样使用的数据在适当情况下可以互换,以便这里描述的本发明的实施例能够以除了在这里图示或描述的那些以外的顺序实施。此外,术语“包括”和“具有”以及他们的任何变形,意图在于覆盖不排他的包含,例如,包含了一系列步骤或单元的过程、方法、系统、产品或设备不必限于清楚地列出的那些步骤或单元,而是可包括没有清楚地列出的或对于这些过程、方法、产品或设备固有的其它步骤或单元。It is to be understood that the terms "first", "second", and the like in the specification and claims of the present invention are used to distinguish similar objects, and are not necessarily used to describe a particular order or order. It is to be understood that the data so used may be interchanged where appropriate, so that the embodiments of the invention described herein can be implemented in a sequence other than those illustrated or described herein. In addition, the terms "comprises" and "comprises" and "the" and "the" are intended to cover a non-exclusive inclusion, for example, a process, method, system, product, or device that comprises a series of steps or units is not necessarily limited to Those steps or units may include other steps or units not explicitly listed or inherent to such processes, methods, products or devices.
组织生理活动,例如,人体的浅表动脉如桡动脉、肱动脉、颈动脉、锁骨下动脉等区域,通常动脉血管离皮肤表面很近,由脉搏波引起的血管振动可以直接传播,并反映到其相邻皮肤表面的振动上。大量的临床实测结果证实,脉搏波其表现出的形态(波的形状)、强度(波的幅值)、速率(波的速度)与节律(波的周期)等方面的综合信号,在相当程度上反映出人体心血管系统的许多生理和病理特征。基于此,在本发明实施例中,提供了一种信号探测器,图1是根据本发明实施例的信号探测器的结构示意图,如图1所示,该信号探测器包括: Tissue physiological activities, for example, the superficial arteries of the human body such as the radial artery, the radial artery, the carotid artery, the subclavian artery, etc., usually the arteries are close to the surface of the skin, and the vibration of the blood vessels caused by the pulse wave can be directly transmitted and reflected to The vibration of its adjacent skin surface. A large number of clinical results confirm that the pulse wave exhibits a comprehensive signal of the shape (wave shape), intensity (wave amplitude), velocity (wave velocity) and rhythm (wave cycle). It reflects many of the physiological and pathological features of the human cardiovascular system. Based on this, in the embodiment of the present invention, a signal detector is provided. FIG. 1 is a schematic structural diagram of a signal detector according to an embodiment of the present invention. As shown in FIG. 1, the signal detector includes:
射频(Radio Frequency,简称为RF)信号发生器11,用于产生RF信号,例如,可以用于产生一个连续波RF信号,信号频率处于RF天线谐振频段内;RF天线12,与上述RF信号发生器11连接,用于根据输入的RF信号激励起交变电场,并接收电场扰动信号,其中,该电场扰动信号为交变电场被待测皮肤表面的振动信号所扰动,待测皮肤表面的振动信号幅度调制到交变电场上产生的调幅信号;调幅包络检波器13,与上述RF天线12连接,用于从电场扰动信号中解调出待测皮肤表面的振动信号。A radio frequency (Radio Frequency, RF for short) signal generator 11 for generating an RF signal, for example, can be used to generate a continuous wave RF signal, the signal frequency is in the RF antenna resonance frequency band; the RF antenna 12, and the RF signal generated above The device 11 is connected to excite an alternating electric field according to the input RF signal and receive an electric field disturbance signal, wherein the electric field disturbance signal is an alternating electric field disturbed by a vibration signal of a surface of the skin to be tested, and the vibration of the surface of the skin to be tested The amplitude of the signal is modulated to an amplitude modulated signal generated on the alternating electric field; an amplitude modulation envelope detector 13 is coupled to the RF antenna 12 for demodulating the vibration signal of the surface of the skin to be tested from the electric field disturbance signal.
通过上述信号探测器,采用将待测皮肤表面的振动信号的幅度调制到交变电场上产生的电场扰动信号,并从该电场扰动信号中解调出待测皮肤表面的振动信号的方式,达到了直接测量组织生理活动的目的,进而解决了相关技术中,对组织生理活动进行测量时,存在测量复杂,使用不便的技术问题。Through the above signal detector, an electric field disturbance signal generated by modulating the amplitude of the vibration signal on the surface of the skin to be measured to the alternating electric field is used, and the vibration signal of the surface of the skin to be tested is demodulated from the electric field disturbance signal to achieve The purpose of directly measuring the physiological activities of the tissue is solved, and in the related art, when measuring the physiological activities of the tissue, there are technical problems of complicated measurement and inconvenient use.
其中,该RF天线可以采用非平衡式馈电,工作在近场模式,用于在待测人体皮肤表面区域产生一个交变的振荡电场;交变电场会被人体皮肤表面的振动所扰动,从而将皮肤表面振动幅度调制到交变电场上,产生调幅的电场扰动信号。另外,需要说明的是,该RF天线也可以为一个或多个,而且,该RF天线可以支持收发共用,也可以支持收发分离。因此,可以根据具体需要或者设计要求灵活选择。Wherein, the RF antenna can adopt an unbalanced feeding mode and operates in a near-field mode for generating an alternating oscillating electric field in a surface area of a human skin to be tested; the alternating electric field is disturbed by vibration of a human skin surface, thereby The skin surface vibration amplitude is modulated onto the alternating electric field to produce an amplitude modulated electric field disturbance signal. In addition, it should be noted that the RF antenna may also be one or more, and the RF antenna may support transmission and reception sharing, and may also support transmission and reception separation. Therefore, it can be flexibly selected according to specific needs or design requirements.
可选地,RF天线可以优先制作在柔性电路板(Flexible Printed Circuit,简称为FPC)介质基板上,其中,该FPC介质基板具有一定的柔韧性,能够与人体组织皮肤表面良好共形、自如贴合。Optionally, the RF antenna can be preferentially fabricated on a flexible printed circuit (FPC) dielectric substrate, wherein the FPC dielectric substrate has a certain flexibility and can conform to the surface of the human tissue and is freely attached. Hehe.
可选地,该RF天线也可以优先制作在柔性金属编织物上,采用金属纱线刺绣工艺或导电布裁剪后粘贴的方式制作在贴身衣物上。Optionally, the RF antenna can also be preferentially fabricated on a flexible metal braid, and is formed on the close-fitting clothing by a metal yarn embroidering process or a conductive cloth after cutting and pasting.
可选地,该RF天线周边预定距离内可以增加一个或多个耦合部件及其对应的匹配电路,以改变该RF天线附近的电场分布,在目标区域获得最大的电场强度;通常该预定距离不大于RF天线工作频率的四分之一波长,其中,匹配电路为耦合部件与电路金属地之间的互联。Optionally, one or more coupling components and their corresponding matching circuits may be added within a predetermined distance around the RF antenna to change the electric field distribution in the vicinity of the RF antenna to obtain a maximum electric field strength in the target region; usually the predetermined distance is not A quarter wavelength greater than the operating frequency of the RF antenna, wherein the matching circuit is an interconnection between the coupling component and the circuit metal ground.
可选地,在RF天线两侧还可以增加一个或多个金属结构作为耦合部件,金属结构可以为矩形片、曲折线或其变形。其中,增加的金属结构与天线间的间距可调。还可以通过优化耦合部件的形状与间距,以及其与电路金属地互联匹配,从而调整天线两侧的电场强度与分布,达到提高皮肤表面振动对天线附近交变电场的调幅效果。Optionally, one or more metal structures may be added on both sides of the RF antenna as coupling members, and the metal structure may be a rectangular piece, a meander line or a deformation thereof. Among them, the increased metal structure and the spacing between the antennas are adjustable. It is also possible to adjust the shape and spacing of the coupling components and their interconnection with the circuit metal to adjust the electric field strength and distribution on both sides of the antenna to improve the amplitude modulation effect of the skin surface vibration on the alternating electric field near the antenna.
为实现装置的简化,优选地,该信号探测器还可以设置一双工器,该双工器与RF天线相连,用于实现RF天线的收发共用。In order to achieve the simplification of the device, preferably, the signal detector can also be provided with a duplexer, which is connected to the RF antenna for realizing the transceiving and sharing of the RF antenna.
为保证安全,在RF天线与待测皮肤表面之间设置一绝缘隔离层;该RF天线和人 体皮肤表面之间有一层低介电损耗的、具生物相容性的绝缘隔离层。To ensure safety, an insulating isolation layer is disposed between the RF antenna and the surface of the skin to be tested; the RF antenna and the person There is a low dielectric loss, biocompatible insulating barrier between the skin surface.
需要说明的是,绝缘隔离层的材质可以为医用硅胶、动物皮质、皮革,例如,该低介电损耗的绝缘隔离层可以采用医用硅胶为主要材质,医用硅胶注塑包裹该RF天线,通过开槽或加棱,使隔离层与皮肤表面之间的介质为空气。It should be noted that the material of the insulating isolation layer may be medical silica gel, animal leather, leather. For example, the low dielectric loss insulating isolation layer may be made of medical silica gel, and the medical silicone injection molding the RF antenna through the slotting. Or ridged so that the medium between the barrier layer and the skin surface is air.
可选地,绝缘隔离层可以采用牛皮、羊皮等动物皮质、皮革为主要材质,将该RF天线用动物皮质蒙皮,通过开槽或加棱,使隔离层与皮肤表面之间的介质为空气。Optionally, the insulating isolation layer may be made of animal skin and leather such as cowhide and sheepskin, and the RF antenna is skinned by the animal cortex, and the medium between the separation layer and the skin surface is air. .
为了使得输出到RF天线上的信号合适,该探测器还可以包括:RF输出功率放大器,用于放大连续波RF信号,并将输出功率限制在-10dBm至20dBm。In order to make the signal output to the RF antenna suitable, the detector may further include an RF output power amplifier for amplifying the continuous wave RF signal and limiting the output power to -10 dBm to 20 dBm.
另外,该探测器还可以包括:RF输出匹配电路,用于将所述RF信号的输出阻抗匹配到RF天线的输入阻抗,例如,将所述RF信号源或RF输出功率放大器输出的RF信号的输出阻抗匹配到RF天线的输入阻抗;RF输入匹配电路,用于完成对从RF天线接收的电场扰动信号的最大功率传输。实现RF信号的尽可能的无损传输。Additionally, the detector may further include: an RF output matching circuit for matching an output impedance of the RF signal to an input impedance of the RF antenna, for example, an RF signal output by the RF signal source or the RF output power amplifier The output impedance is matched to the input impedance of the RF antenna; the RF input matching circuit is used to perform maximum power transfer to the electric field disturbance signal received from the RF antenna. Achieve as much lossless transmission as possible of the RF signal.
为了有效地控制干扰信号的干扰,该信号探测器,还可以包括:第一滤波器,用于滤除连续波RF信号工作频段外的干扰信号。In order to effectively control the interference of the interference signal, the signal detector may further include: a first filter for filtering out the interference signal outside the working frequency band of the continuous wave RF signal.
为了进一步地避免干扰信号的干扰,该信号探测器,还可以包括:第二滤波器,用于根据人体皮肤表面振动信号的频谱特点,选取合适截止频率,滤除其他干扰信号。In order to further avoid the interference of the interference signal, the signal detector may further include: a second filter, configured to select a suitable cutoff frequency according to the spectral characteristics of the surface vibration signal of the human skin, and filter out other interference signals.
在解调出待测皮肤表面的振动信号后,为有效实现对该待测皮肤表面的振动信号进行有效处理,该信号探测器还包括:信号放大器,用于将解调出的所述待测皮肤表面的振动信号进行放大;AD转换器,用于将解调出的人体皮肤表面振动信号转换成数字信号;以及数字信号处理器,用于对转换成的数字信号进行后续的算法处理和显示。After demodulating the vibration signal of the surface of the skin to be tested, in order to effectively implement the effective processing of the vibration signal of the skin surface to be tested, the signal detector further includes: a signal amplifier for demodulating the to-be-tested The vibration signal of the skin surface is amplified; an AD converter for converting the demodulated human skin surface vibration signal into a digital signal; and a digital signal processor for performing subsequent algorithm processing and display on the converted digital signal .
需要说明的是,上述实施例所提供的探测器可以为一种可穿戴式用于检测人体皮肤表面振动的探测器,有效解决了相关技术中探测器检测生理组织时需要气囊加压、直接皮肤接触,易受干扰、检测精度低等技术问题。It should be noted that the detector provided by the above embodiment may be a wearable detector for detecting surface vibration of a human skin, which effectively solves the problem that the detector needs airbag pressure and direct skin when detecting the physiological tissue in the related art. Contact, susceptible to interference, low detection accuracy and other technical issues.
下面以信号探测器为一种可穿戴式用于检测人体皮肤表面振动的探测器为例进行说明。In the following, a signal detector is used as a wearable detector for detecting surface vibration of a human skin as an example.
图2是根据本发明第一实施例的可穿戴式用于检测人体皮肤表面振动的探测器的RF天线的示意图,如图2所示,该RF天线包括:2 is a schematic diagram of an RF antenna of a wearable detector for detecting surface vibration of a human skin according to a first embodiment of the present invention. As shown in FIG. 2, the RF antenna includes:
RF天线辐射体,该RF天线辐射体为单一辐射体,采用非平衡式馈电,以提高天 线与人体组织的电场耦合强度,并且有利于天线周围耦合部件的设计。RF antenna radiator, the RF antenna radiator is a single radiator, using unbalanced feeding to improve the sky The line is coupled to the electric field of the body tissue and contributes to the design of the coupling components around the antenna.
耦合部件1、耦合部件2,分别分布在RF天线辐射体两侧;耦合部件的形状、与RF天线辐射体的间接可调。The coupling member 1 and the coupling member 2 are respectively distributed on both sides of the RF antenna radiator; the shape of the coupling member and the indirect adjustment of the RF antenna radiator.
匹配电路1、匹配电路2,分别连接对应的耦合部件,并实现不同的匹配,达到调整电场分布,改善皮肤表面振动的幅度调制效果。The matching circuit 1 and the matching circuit 2 respectively connect the corresponding coupling components and realize different matching, thereby adjusting the electric field distribution and improving the amplitude modulation effect of the skin surface vibration.
图3是根据本发明第一实施例的可穿戴式用于检测人体皮肤表面振动的探测器装置的示意图,如图3所示,该探测器装置包括:3 is a schematic view of a wearable detector device for detecting surface vibration of a human skin according to a first embodiment of the present invention. As shown in FIG. 3, the detector device includes:
RF天线12,该RF天线可以采用非平衡式馈电,工作在近场模式。RF antenna 12, which can be fed unbalanced and operates in near field mode.
其中,该RF天线12可以优先设计成柔性天线,以便更易与人体贴合;可选地,该RF天线12采用平面印制方式制作在柔性FPC介质基板上;可选地,该RF天线12采用导电纱线刺绣工艺或导电织布裁剪后粘贴方式制作在贴身穿戴的衣物上;The RF antenna 12 can be preferentially designed as a flexible antenna to be more easily attached to the human body; optionally, the RF antenna 12 is formed on the flexible FPC dielectric substrate by planar printing; alternatively, the RF antenna 12 is adopted. The conductive yarn embroidering process or the conductive woven fabric is cut and pasted and made on the clothes worn by the body;
双工器38;与上述RF天线相连,实现RF天线的收发共用;a duplexer 38; connected to the RF antenna to implement transceiver sharing of the RF antenna;
绝缘隔离层39;用于在上述RF天线和人体皮肤表面之间有一层低介电损耗的、具生物相容性的绝缘隔离层;An insulating isolation layer 39; a biocompatible insulating isolation layer for a low dielectric loss between the RF antenna and the human skin surface;
其中,绝缘隔离层具有低的介电损耗,厚度应尽量薄,建议不超过1mm,以降低能量在介质中传播的损耗。绝缘隔离层具有良好的生物相容性以保证与人体皮肤长期接触的安全;绝缘层还具有较好的机械柔韧性,能与人体各部位皮肤良好共形,并在两者之间应引入足够的空气间隔,以保障绝缘隔离层没有压迫皮肤表面振动。Among them, the insulating isolation layer has a low dielectric loss, and the thickness should be as thin as possible, and it is recommended not to exceed 1 mm to reduce the loss of energy propagation in the medium. The insulating insulation layer has good biocompatibility to ensure long-term contact with human skin. The insulating layer also has good mechanical flexibility and can conform well to the skin of various parts of the human body, and should be introduced between the two. The air gap is to ensure that the insulating barrier does not oppress the surface vibration of the skin.
可选的,低介电损耗的、具生物相容性的绝缘隔离层采用医用硅胶为主要材质,医用硅胶注塑包裹RF天线,通过开槽或加棱,使隔离层与皮肤表面之间的介质为空气。Optionally, the low dielectric loss, biocompatible insulating isolation layer is made of medical silica gel. The medical silicone injection molding RF antenna is used to form a medium between the separation layer and the skin surface by slotting or ribbing. For the air.
可选的,低介电损耗的、具生物相容性的绝缘隔离层采用牛皮、羊皮等动物皮质、皮革为主要材质,将RF天线用动物皮质蒙皮,通过开槽或加棱,使隔离层与皮肤表面之间的介质为空气。Optionally, the low dielectric loss, biocompatible insulating insulation layer is made of animal skin and leather such as cowhide and sheepskin. The RF antenna is skinned by animal leather and is isolated by slotting or ribbing. The medium between the layer and the skin surface is air.
RF信号发生器11;产生一个的连续波RF信号,信号频率为RF天线谐振频段内;RF signal generator 11; generating a continuous wave RF signal, the signal frequency is within the resonant frequency band of the RF antenna;
RF输出功率放大器36;放大连续波RF信号,输出功率限制在-10dBm至20dBm;RF output power amplifier 36; amplifying the continuous wave RF signal, the output power is limited to -10dBm to 20dBm;
RF输出匹配电路37;将RF输出功率放大器的输出阻抗以最大功率匹配方式匹配到天线的输入阻抗; An RF output matching circuit 37; matching the output impedance of the RF output power amplifier to the input impedance of the antenna in a maximum power matching manner;
RF输入匹配电路35;将天线的输出阻抗以最大功率匹配方式匹配到下一级电路;An RF input matching circuit 35; matching the output impedance of the antenna to the next stage circuit in a maximum power matching manner;
第一滤波器34;滤除连续波RF信号工作频段外的干扰信号;a first filter 34; filtering out interference signals outside the working frequency band of the continuous wave RF signal;
调幅包络检波器13;解调携带有皮肤表面振动信号的调幅电场扰动信号;An amplitude modulation envelope detector 13; demodulating an amplitude modulated electric field disturbance signal carrying a skin surface vibration signal;
第二滤波器33;根据人体皮肤表面振动信号的特点,选取合适截止频率,滤除其他干扰信号;a second filter 33; according to the characteristics of the surface vibration signal of the human skin, selecting a suitable cutoff frequency to filter out other interference signals;
信号放大器32;用于将解调出的所述待测皮肤表面的振动信号进行放大;a signal amplifier 32; for amplifying the demodulated vibration signal of the surface of the skin to be tested;
AD转换器与数字信号处理器31;将解调出的人体皮肤表面振动信号转换成数字信号,并进行后续的算法处理。The AD converter and the digital signal processor 31 convert the demodulated human skin surface vibration signal into a digital signal and perform subsequent algorithm processing.
图4是根据本发明实施例的人体桡动脉处皮肤表面振动的探测结果的示意图,采用418MHz的探测信号,通过腕带式手表测试得到的脉搏信号波形如图4所示,测试结果同时显示:波峰幅值8520000左右,波谷幅值8350000左右,脉搏波状态是随时间连续的等。测试结果表明,本发明实施例的人体皮肤表面振动的探测方法可用并具有良好的结果。4 is a schematic diagram showing the detection result of the skin surface vibration at the radial artery of the human body according to an embodiment of the present invention. The pulse signal waveform obtained by the wristband type watch test using the 418 MHz detection signal is as shown in FIG. 4, and the test result also shows: The peak amplitude is about 8520000, the trough amplitude is about 8350000, and the pulse wave state is continuous with time. The test results show that the method for detecting surface vibration of human skin according to the embodiment of the present invention can be used and has good results.
图5是根据本发明第二实施例的可穿戴式用于检测人体皮肤表面振动的探测器装置的示意图,如图5所示,该实施例与图3的区别在于,将调幅包络检波器13换成了混频器51,且省略了信号放大器32。混频器51需要RF信号发生器11提供一路RF信号作为本振信号用于与第一滤波器34之后的接收信号进行同步解调,该方法可以提高解调电路转换增益,节省掉信号放大器。5 is a schematic diagram of a wearable detector device for detecting surface vibration of a human skin according to a second embodiment of the present invention. As shown in FIG. 5, this embodiment differs from FIG. 3 in that an amplitude modulation envelope detector is used. 13 is replaced with a mixer 51, and the signal amplifier 32 is omitted. The mixer 51 requires the RF signal generator 11 to provide an RF signal as a local oscillator signal for synchronous demodulation with the received signal after the first filter 34. This method can improve the conversion gain of the demodulation circuit and save the signal amplifier.
根据本发明实施例,提供了一种可穿戴式用于检测人体皮肤表面振动的探测方法。该探测方法可以由本发明第一实施例的探测器装置执行,图6是根据本发明第一实施例的流程图,如图6所示,该方法包括如下步骤:According to an embodiment of the present invention, a wearable method for detecting surface vibration of a human skin is provided. The detecting method can be performed by the detecting device of the first embodiment of the present invention. FIG. 6 is a flow chart according to the first embodiment of the present invention. As shown in FIG. 6, the method includes the following steps:
步骤S101,将RF天线放置在人体有浅表振动的皮肤表面,如桡动脉、肱动脉、颈动脉、锁骨下动脉等对应位置处;Step S101, placing the RF antenna on a skin surface of the human body having superficial vibration, such as a radial artery, a radial artery, a carotid artery, a subclavian artery, or the like;
步骤S102,RF信号发生器产生一个连续波RF信号,通过RF输出功率放大器放大,经RF输出匹配电路,连接到天线双工器信号输入端;此时,天线周围附近会激励起交变的振荡电场;交变电场会被人体皮肤表面的振动所扰动,从而将皮肤表面振动幅度调制到交变电场上,产生调幅的电场扰动信号;Step S102, the RF signal generator generates a continuous wave RF signal, which is amplified by the RF output power amplifier, and connected to the antenna duplexer signal input terminal through the RF output matching circuit; at this time, the alternating oscillation is excited near the antenna. The electric field; the alternating electric field is disturbed by the vibration of the surface of the human skin, thereby modulating the amplitude of the skin surface vibration to the alternating electric field, and generating an amplitude-modulated electric field disturbance signal;
步骤S103,该电场扰动信号被RF天线探测到,经过双工器输出端口连接到RF输入匹配电路; Step S103, the electric field disturbance signal is detected by the RF antenna, and is connected to the RF input matching circuit through the duplexer output port;
步骤S104,经过第一滤波器滤除工作频段外的干扰信号,由调幅包络检波器解调出人体皮肤表面振动信号;Step S104, filtering the interference signal outside the working frequency band by the first filter, and demodulating the surface vibration signal of the human skin by the amplitude modulation envelope detector;
步骤S105,解调出的人体皮肤表面振动信号,经第二滤波器滤波,通过AD转换,输入到数字信号处理器中做后续处理。Step S105, the demodulated human skin surface vibration signal is filtered by the second filter, input to the digital signal processor for subsequent processing by AD conversion.
上述本发明实施例序号仅仅为了描述,不代表实施例的优劣。The serial numbers of the embodiments of the present invention are merely for the description, and do not represent the advantages and disadvantages of the embodiments.
在本发明的上述实施例中,对各个实施例的描述都各有侧重,某个实施例中没有详述的部分,可以参见其他实施例的相关描述。In the above-mentioned embodiments of the present invention, the descriptions of the various embodiments are different, and the parts that are not detailed in a certain embodiment can be referred to the related descriptions of other embodiments.
在本申请所提供的几个实施例中,应该理解到,所揭露的技术内容,可通过其它的方式实现。其中,以上所描述的装置实施例仅仅是示意性的,例如单元的划分,可以为一种逻辑功能划分,实际实现时可以有另外的划分方式,例如多个单元或组件可以结合或者可以集成到另一个系统,或一些特征可以忽略,或不执行。另一点,所显示或讨论的相互之间的耦合或直接耦合或通信连接可以是通过一些接口,单元或模块的间接耦合或通信连接,可以是电性或其它的形式。In the several embodiments provided by the present application, it should be understood that the disclosed technical contents may be implemented in other manners. The device embodiments described above are only schematic. For example, the division of cells may be a logical function division. In actual implementation, there may be another division manner. For example, multiple units or components may be combined or integrated into Another system, or some features can be ignored or not executed. In addition, the mutual coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection through some interface, unit or module, and may be electrical or otherwise.
作为分离部件说明的单元可以是或者也可以不是物理上分开的,作为单元显示的部件可以是或者也可以不是物理单元,即可以位于一个地方,或者也可以分布到多个单元上。可以根据实际的需要选择其中的部分或者全部单元来实现本实施例方案的目的。The units described as separate components may or may not be physically separate, and the components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of the embodiment.
另外,在本发明各个实施例中的各功能单元可以集成在一个处理单元中,也可以是各个单元单独物理存在,也可以两个或两个以上单元集成在一个单元中。上述集成的单元既可以采用硬件的形式实现,也可以采用软件功能单元的形式实现。In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above integrated unit can be implemented in the form of hardware or in the form of a software functional unit.
集成的单元如果以软件功能单元的形式实现并作为独立的产品销售或使用时,可以存储在一个计算机可读取存储介质中。基于这样的理解,本发明的技术方案本质上或者说对现有技术做出贡献的部分或者该技术方案的全部或部分可以以软件产品的形式体现出来,该计算机软件产品存储在一个存储介质中,包括若干指令用以使得一台计算机设备(可为个人计算机、服务器或者网络设备等)执行本发明各个实施例方法的全部或部分步骤。而前述的存储介质包括:U盘、只读存储器(ROM,Read-Only Memory)、随机存取存储器(RAM,Random Access Memory)、移动硬盘、磁碟或者光盘等各种可以存储程序代码的介质。An integrated unit, if implemented in the form of a software functional unit and sold or used as a standalone product, can be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention, which is essential or contributes to the prior art, or all or part of the technical solution, may be embodied in the form of a software product stored in a storage medium. A number of instructions are included to cause a computer device (which may be a personal computer, server or network device, etc.) to perform all or part of the steps of the various embodiments of the present invention. The foregoing storage medium includes: a U disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a removable hard disk, a magnetic disk, or an optical disk, and the like. .
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。 The above description is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can also make several improvements and retouchings without departing from the principles of the present invention. It should be considered as the scope of protection of the present invention.

Claims (11)

  1. 一种信号探测器,包括:A signal detector comprising:
    射频RF信号发生器,用于产生RF信号;An RF RF signal generator for generating an RF signal;
    RF天线,用于根据输入的所述RF信号激励起交变电场,并接收电场扰动信号;其中,所述电场扰动信号为交变电场被待测皮肤表面的振动信号所扰动,待测皮肤表面的振动信号幅度调制到交变电场上产生的调幅信号;An RF antenna for exciting an alternating electric field according to the input RF signal and receiving an electric field disturbance signal; wherein the electric field disturbance signal is an alternating electric field disturbed by a vibration signal of a surface of the skin to be tested, the surface of the skin to be tested The amplitude of the vibration signal is modulated to an amplitude modulated signal generated on the alternating electric field;
    调幅包络检波器,用于从所述电场扰动信号中解调出所述待测皮肤表面的振动信号。An amplitude modulation envelope detector for demodulating a vibration signal of the surface of the skin to be tested from the electric field disturbance signal.
  2. 根据权利要求1所述的信号探测器,其中,还包括:The signal detector of claim 1 further comprising:
    RF输出功率放大器,用于放大所述射频RF信号发生器产生的RF信号,并控制输出功率在-10dBm至20dBm;An RF output power amplifier for amplifying the RF signal generated by the RF RF signal generator and controlling the output power from -10 dBm to 20 dBm;
    RF输出匹配电路,用于将所述RF信号的输出阻抗匹配到RF天线的输入阻抗;An RF output matching circuit for matching an output impedance of the RF signal to an input impedance of the RF antenna;
    RF输入匹配电路,用于完成对从所述RF天线接收的所述电场扰动信号的最大功率传输。An RF input matching circuit for performing maximum power transfer of the electric field disturbance signal received from the RF antenna.
  3. 根据权利要求1所述的信号探测器,其中,还包括:The signal detector of claim 1 further comprising:
    第一滤波器,用于滤除从所述RF输入匹配电路输出的电场扰动信号中所述RF信号的工作频段外的干扰信号;a first filter, configured to filter out an interference signal outside the working frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit;
    第二滤波器,用于根据所述待测皮肤表面的振动信号的频谱特征,滤除从所述调幅包络检波器中输出的所述待测皮肤表面的振动信号中预定截止频率外的干扰信号;a second filter, configured to filter interference from a predetermined cutoff frequency of the vibration signal of the surface of the skin to be tested outputted from the amplitude modulation envelope detector according to a spectral characteristic of the vibration signal of the skin surface to be tested signal;
    信号放大器,用于将解调出的所述待测皮肤表面的振动信号进行放大;a signal amplifier for amplifying the demodulated vibration signal of the surface of the skin to be tested;
    模拟数字AD转换器,用于将解调出的所述待测皮肤表面的振动信号转换为数字信号;An analog digital AD converter for converting the demodulated vibration signal of the surface of the skin to be tested into a digital signal;
    数据信号处理器,用于对所述数字信号进行处理和显示。A data signal processor for processing and displaying the digital signal.
  4. 根据权利要求1所述的信号探测器,其中,所述RF天线为一个或多个,所述RF天线支持收发共用,或者支持收发分离,其中,所述RF天线采用非平衡式馈电。 The signal detector of claim 1 wherein said RF antennas are one or more, said RF antennas support transmission and reception sharing, or support for transmission and reception separation, wherein said RF antennas employ unbalanced feeds.
  5. 根据权利要求1所述的信号探测器,其中,The signal detector according to claim 1, wherein
    所述RF天线制作在柔性电路板FPC上;The RF antenna is fabricated on a flexible circuit board FPC;
    或者,or,
    所述RF天线制作在柔性导电编织物上,其中,采用导电纱线刺绣工艺或导电织布裁剪后粘贴的方式制作在贴身衣物上。The RF antenna is fabricated on a flexible conductive braid, wherein the conductive yarn embroidering process or the conductive woven fabric is cut and pasted to form the close-fitting clothing.
  6. 根据权利要求1所述的信号探测器,其中,The signal detector according to claim 1, wherein
    所述RF天线周边预定距离内增加有一个或多个耦合部件,以及所述一个或多个耦合部件对应的匹配电路,用于改变所述RF天线的电场分布。One or more coupling members are added within a predetermined distance around the RF antenna, and matching circuits corresponding to the one or more coupling members are used to change the electric field distribution of the RF antenna.
  7. 根据权利要求6所述的信号探测器,其中,The signal detector according to claim 6, wherein
    所述耦合部件为金属结构,所述耦合部件的形状为以下之一:矩形片、曲折线、矩形片的变形、曲折线的变形,其中,所述耦合部件与所述RF天线间的间距可调;The coupling component is a metal structure, and the shape of the coupling component is one of the following: a rectangular piece, a meander line, a deformation of a rectangular piece, and a deformation of a meander line, wherein a spacing between the coupling part and the RF antenna can be Tune
    所述一个或多个耦合部件对应的匹配电路用于互联对应的耦合部件和电路金属地。A matching circuit corresponding to the one or more coupling components is used to interconnect the corresponding coupling component and the circuit metal ground.
  8. 根据权利要求1所述的信号探测器,其中,还包括:The signal detector of claim 1 further comprising:
    绝缘隔离层,设置于所述RF天线与待测皮肤表面之间,用于隔离出空气间隔。An insulating spacer disposed between the RF antenna and the surface of the skin to be tested for isolating the air gap.
  9. 根据权利要求8所述的信号探测器,其中,所述绝缘隔离层的材质为医用硅胶、动物皮质、皮革。The signal detector according to claim 8, wherein the insulating isolation layer is made of medical silica gel, animal leather, and leather.
  10. 一种信号探测方法,包括:A signal detection method includes:
    采用射频RF信号发生器产生RF信号;Generating an RF signal using an RF RF signal generator;
    通过RF天线根据输入的所述RF信号激励起交变电场,并接收电场扰动信号;其中,所述电场扰动信号为交变电场被待测皮肤表面的振动信号所扰动,待测皮肤表面的振动信号幅度调制到交变电场上产生的调幅信号;The alternating electric field is excited by the RF antenna according to the input RF signal, and receives an electric field disturbance signal; wherein the electric field disturbance signal is an alternating electric field disturbed by a vibration signal of a surface of the skin to be tested, and the vibration of the surface of the skin to be tested The signal amplitude is modulated to an amplitude modulated signal generated on an alternating electric field;
    采用调幅包络检波器从所述电场扰动信号中解调出所述待测皮肤表面的振动信号。An amplitude modulation envelope detector is used to demodulate the vibration signal of the surface of the skin to be tested from the electric field disturbance signal.
  11. 根据权利要求10所述的信号探测方法,其中, The signal detecting method according to claim 10, wherein
    在采用所述RF信号发生器产生所述RF信号之后,采用RF输出功率放大器放大所述射频RF信号发生器产生的RF信号;并通过RF输出匹配电路将所述RF信号的输出阻抗匹配到RF天线的输入阻抗;After generating the RF signal by using the RF signal generator, amplifying the RF signal generated by the RF RF signal generator with an RF output power amplifier; and matching the output impedance of the RF signal to the RF by an RF output matching circuit The input impedance of the antenna;
    在采用所述调幅包络检波器从所述电场扰动信号中解调出所述待测皮肤表面的振动信号之前,采用RF输入匹配电路完成对从所述RF天线接收的所述电场扰动信号的最大功率传输;以及采用第一滤波器滤除从所述RF输入匹配电路输出的电场扰动信号中所述RF信号的工作频段外的干扰信号;Performing on the electric field disturbance signal received from the RF antenna by using an RF input matching circuit before demodulating the vibration signal of the skin surface to be tested from the electric field disturbance signal by using the amplitude modulation envelope detector a maximum power transmission; and a first filter is used to filter out an interference signal outside the operating frequency band of the RF signal in the electric field disturbance signal output from the RF input matching circuit;
    在采用调幅包络检波器从所述电场扰动信号中解调出所述待测皮肤表面的振动信号之后,采用第二滤波器根据所述待测皮肤表面的振动信号的频谱特征,滤除从所述调幅包络检波器中输出的所述待测皮肤表面的振动信号中预定截止频率外的干扰信号;通过信号放大器,将解调出的所述待测皮肤表面的振动信号进行放大;通过模拟数字AD转换器将解调出的所述待测皮肤表面的振动信号转换为数字信号;以及采用数据信号处理器对所述数字信号进行处理和显示。 After demodulating the vibration signal of the surface of the skin to be tested from the electric field disturbance signal by using an amplitude modulation envelope detector, filtering the signal according to the spectral characteristics of the vibration signal of the skin surface to be tested by using a second filter An interference signal outside the predetermined cutoff frequency of the vibration signal of the skin surface to be tested outputted in the amplitude modulation envelope detector; the demodulated vibration signal of the surface of the skin to be tested is amplified by a signal amplifier; An analog digital AD converter converts the demodulated vibration signal of the surface of the skin to be tested into a digital signal; and processes and displays the digital signal with a data signal processor.
PCT/CN2017/092524 2017-07-11 2017-07-11 Signal detector and signal detection method WO2019010635A1 (en)

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