WO2017204384A1 - Blood pressure measuring apparatus and blood pressure measuring method using same - Google Patents

Abstract

The present invention relates to a blood pressure measuring apparatus and a blood pressure measuring method using the same. The apparatus can calculate a sensed blood pressure value by using a maximum pulse pressure and a maximum pressurization value generating the maximum pulse pressure among pressurization values when a pressurization unit pressurizes a measurement region, and calibrate the sensed blood pressure value through an elasticity modulus of a skin and a blood vessel, a reduction ratio of a pulse pressure, and stiffness of a blood vessel and a skin of the measurement region, to calculate an actual blood pressure value, so as to precisely measure a blood pressure of a measurement subject. Further, the apparatus can precisely and continuously measure a blood pressure of a measurement subject by a predetermined period for a predetermined time, so as to check a daily blood pressure change for a normal person through a blood pressure observation or a continuous blood pressure measurement at one minute intervals, or secure a minute change or an average value for ten seconds with respect to a blood pressure which may be changed by breathing or other factors. Therefore, the apparatus can more stably monitor blood pressure.

Description

Blood pressure measuring device and blood pressure measuring method using the same

The present invention relates to a blood pressure measuring apparatus and a blood pressure measuring method using the same. More specifically, the reaction pressure is measured by pressurizing a blood vessel, and the blood pressure is measured through the blood pressure. Blood pressure measuring apparatus capable of continuous blood pressure tracking relates to a continuous blood pressure measuring method using the same.

Generally, a device for measuring blood pressure includes a device using an invasive method and a device using a noninvasive method.

A typical example is a method of directly measuring the pressure of blood vessels by inserting a catheter for measuring the pressure of blood vessels into the peripheral artery by the invasive method, but this method has a risk of arterial bleeding and requires invasion. There is a disadvantage that it is unsuitable as a device which is frequently and conveniently used for the measurement of.

As the non-invasive method, a mercury sphygmomanometer is typically used. In such a method using a mercury sphygmomanometer, pressure is applied to the measurement site, and the blood pressure is detected at the start point and the vanishing point of the pulse by detecting a pulse with a stethoscope or a hand while gradually exhausting the blood pressure.

The blood pressure measuring apparatus using the non-invasive method is a blood pressure measuring apparatus using an oscillometric method as an electronic measuring method. The oscillometric method uses a pressure sensor to measure the magnitude of the pressure oscillation in the cuff when the cuff is wrapped around the upper arm, lower arm or wrist to inflate air, and then the air is removed again. It is a method of measuring blood pressure by detecting and recording.

That is, the blood pressure measuring device using an oscillometric method is a cuff which can wind the upper arm, the lower arm or the wrist and the air can be injected therein, and a pressure sensor that detects the magnitude of the pressure oscillation generated in the cuff. It includes.

The blood pressure measuring apparatus using the oscillometric method has an advantage of easily measuring blood pressure by wrapping a cuff around the upper arm, the lower arm, or the wrist, but distortion of the signal occurs by using air as a pressure transfer medium.

In addition, the blood pressure measurement device using the oscillometric method can simplify the interpretation of the signal when the intended air pressure change in the cuff is secured, but the amount of air remaining in the air chamber and Because the system is injected and leaked in response to pressure, it is difficult to linearly increase or decrease the pressure in the air chamber, which makes it difficult to linearly adjust the response of the vessel.

Therefore, the blood pressure measuring apparatus using the oscillometric method has a problem of lower accuracy in blood pressure measurement compared to the blood pressure measuring apparatus by the invasive method due to the difficulty of linearly controlling the signal distortion and the response of the medium. there was.

In addition, the blood pressure measuring apparatus using the oscillometric method has a problem that it is impossible to measure the continuous blood pressure because it takes time to inflate and deflate the cuff by injecting air into the cuff.

In addition, the blood pressure may need to be periodically checked according to the patient's condition, and the blood pressure measuring device using an oscillometric method may be worn by the cuff wrapped around the upper arm or wrist, and the patient may press the entire part during blood pressure measurement. When the blood pressure is measured during bedtime, there is a problem of disturbing the patient's sleep and worsening the patient's health.

On the other hand, the device has recently been developed to compensate for the shortcomings of the non-invasive blood pressure measuring device to continuously measure the blood pressure using a non-invasive method.

In the case of such a device, an electrocardiogram (ECG) and a photoplethysmography (PPG) are provided to measure blood pressure, and it is cumbersome because two devices must be provided and blood pressure of various parts of the body must be measured. In addition, the accuracy of the measured blood pressure depends on the precision of the two types of machines used in the method, rather than the precision by the blood pressure itself.

An object of the present invention is to pressurize the blood vessels of the radial artery, measure the reaction pressure according to the pressurization, and correct them through the elastic modulus of the skin and blood vessels as well as the stiffness of the blood vessels and the skin, the pulse pressure suppression coefficient according to the pressure to accurately An object of the present invention is to provide a blood pressure measuring device capable of measuring and a blood pressure measuring method using the same.

Another object of the present invention is to provide a blood pressure measuring device capable of continuously measuring blood pressure by measuring and tracking the pulse pressure change every beat in the state of maintaining the pressing force in which the average blood pressure is measured, and a blood pressure measuring method using the same.

One embodiment of the blood pressure measuring device according to the present invention for achieving the above object is a pressure unit for pressing the measurement site for measuring the pulse pressure, the pressure value pressed by the pressure unit and the pressure at the pressure measurement site A sensor unit configured to calculate a maximum blood pressure value that generates the highest pulse pressure among the pressure values detected by the sensor unit, and a blood pressure calculation unit that calculates a sensing blood pressure value using the maximum pulse pressure; It characterized in that it comprises a blood pressure correction unit for calculating the actual blood pressure value by correcting through the elastic modulus of the blood vessels, pulse pressure decay rate, blood vessels and the stiffness of the skin.

In the present invention, the blood pressure calculation unit checks the highest pressure value as the sensing average blood pressure value (sMBP) of the measurement target sensed by the sensor unit, and the maximum pulse pressure value is the sensing pulse pressure of the measurement target sensed by the sensor unit. By checking the value sPP, a sensing systolic blood pressure value sSBP and a sensing diastolic blood pressure value sDBP may be calculated from the sensing average blood pressure value sMBP and the sensing pulse pressure value sPP.

One embodiment of the blood pressure measuring apparatus according to the present invention further includes a correction factor calculation unit for calculating the elastic modulus (K) of the skin and blood vessels, the pulse pressure decay rate (a), the stiffness of the blood vessels and skin (u), the correction factor The calculation unit is mathematical

To calculate the elastic modulus (K) of the skin and blood vessels,

The pulsation pressure attenuation rate (a) is calculated and the stiffness (u) of the skin is calculated as the inverse of the pressure compliance (b) of the blood vessel, and the pressure compliance (b) of the blood vessel is the time taken for the blood vessel to expand by pressure. Can be.

(dP: pressure value, dx: vertical displacement of skin, dAP: change in pressure value, dpp: change in sensing pulse pressure value (sPP), α: sensor adaptation coefficient)

One embodiment of the blood pressure measuring apparatus according to the present invention measures the pulse wave for a predetermined time while maintaining the highest pressing force applied to the measurement site in the pressing portion, by measuring the sensing pulse pressure value per beat the same actual average blood pressure value The blood pressure calculating unit and the blood pressure correcting unit may further include a continuous blood pressure value tracking unit for continuously calculating and tracking an actual systolic blood pressure value rSBP and an actual diastolic blood pressure value rDBP.

One embodiment of the blood pressure measuring apparatus according to the present invention further comprises a continuous measurement information input unit for inputting the measurement period and the continuous measurement time in the continuous blood pressure value tracking operation unit, the continuous blood pressure value tracking operation unit actual average blood pressure value (rMBP) After the operation of continuously measuring the blood pressure during the input continuous measurement time in the fixed state) is detected after the input measuring cycle again the maximum pressure value and the maximum pulse pressure value for deriving the maximum pressure value, thereby detecting The blood pressure calculation unit and the blood pressure correction unit newly calculate the actual average blood pressure value (rMBP), measure the pulse wave for a predetermined time while maintaining the maximum applied pressure applied to the measurement site in the pressure unit, and sense pulse pressure value for each beat. The blood pressure calculation is performed by calculating the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) on the same actual mean blood pressure value (rMBP). By repeatedly calculating the portion and the blood pressure correcting unit continuously, it is possible to repeat the measurement of continuous blood pressure for a predetermined time in a predetermined time period.

In the present invention, the blood pressure correction unit calculates the actual pulse pressure value rPP and the actual average blood pressure value rMBP through Equations 4 and 5 below, and the actual pulse pressure value rPP and the actual average blood pressure value rMBP. The actual systolic blood pressure value rSBP and the actual diastolic blood pressure value rDBP can be calculated.

[Equation 4]

rPP = k × sPP + a × sPP + (sPP + sMBP) × u + C

[Equation 5]

rMBP = k × sMBP + sMBP × u + C

k: modulus of elasticity

a: pulse pressure reduction rate

u: stiffness of blood vessels and skin

C: mean blood pressure correction constant (0.1mmHg ~ 0.9mmHg)

In the present invention, the sensor unit may be an array sensor mounted on the back of the pressing unit to search for the position of the measuring vessel in which the largest and clearest signal is input when pressing the skin of the measuring unit to position the pressing unit in the measuring vessel. .

One embodiment of the blood pressure measuring method according to the present invention in order to achieve the above object is to press the measurement site for measuring the pulse pressure of the subject to measure the maximum pressure value to generate the maximum pressure and the maximum pulse pressure at the measurement site Sensing blood pressure calculation step of calculating the sensing blood pressure value with the highest pressure value and the maximum pressure value derived from the detection step, the pulse pressure detection step, the elastic modulus of the skin and blood vessels of the measurement site, pulse pressure attenuation rate, blood vessels and skin It characterized in that it comprises a blood pressure correction step of calculating the actual blood pressure value by correcting through the stiffness.

In the present invention, the sensing blood pressure calculation step confirms the highest pressure value as the sensing average blood pressure value (sMBP) of the measurement target, and checks the highest pulse pressure value as the sensing pulse pressure value (sPP) of the measurement target. sSBP), and the sensed diastolic blood pressure value sDBP may be calculated.

An embodiment of the blood pressure measuring method according to the present invention further comprises a correction factor calculation step which is performed after the sensing blood pressure calculation step and before the blood pressure correction step, and calculates elastic modulus, pulse pressure decay rate, stiffness of blood vessels and skin. The correction factor calculation step is

To calculate the elastic modulus (K) of the skin and blood vessels,

The pulsation pressure attenuation rate (a) is calculated and the stiffness (u) of the skin is calculated as the inverse of the pressure compliance (b) of the blood vessel, and the pressure compliance (b) of the blood vessel is the time taken for the blood vessel to expand by pressure. Can be.

(dP: pressure value, dx: vertical displacement of skin, dAP: change in pressure value, dpp: change in sensing pulse pressure value (sPP), α: sensor adaptation coefficient)

In the present invention, the blood pressure correction step calculates the actual pulse pressure value (rPP) and the actual average blood pressure value (rMBP) through the following Equations 4 and 5, and the actual pulse pressure value (rPP) and the actual average blood pressure value (rMBP). ), The actual systolic blood pressure value rSBP and the actual diastolic blood pressure value rDBP can be calculated.

[Equation 4]

rPP = k × sPP + a × sPP + (sPP + sMBP) × u + C

[Equation 5]

rMBP = k × sMBP + sMBP × u + C

k: modulus of elasticity

a: pulse pressure reduction rate

u: stiffness of blood vessels and skin

C: mean blood pressure correction constant (0.1mmHg ~ 0.9mmHg)

One embodiment of the blood pressure measuring method according to the present invention is a blood vessel identification step of locating the pressing unit for measuring the pulse pressure in the measurement vessel by searching for the position of the measurement vessel where the largest and clearest signal is input when pressing the skin of the measurement site. It may further include.

In the present invention, the step of identifying blood vessels is located at a plurality of points estimated to be the positions of the measurement vessels in which the array sensor is mounted on the rear surface, applying the same pressing force at each point, and the positions of the pulse pressure reacting when the pressing force is applied. A pressure measurement process for storing the pressure, a pressure comparison process for selecting a pulse pressure having the largest pulse pressure by comparing the pulse pressures at each point measured in the pulse pressure measurement process, and the pressure to a point corresponding to the pulse pressure selected in the pulse pressure comparison process It may include a pressing part positioning process for moving the part.

One embodiment of the blood pressure measuring method according to the present invention measures the pulse wave for a predetermined time while maintaining the maximum pressure applied to the measurement site after the blood pressure correction step, by measuring the sensing pulse pressure value per beat the same actual average blood pressure A continuous blood pressure value tracking step of continuously calculating and tracking the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) in the sensing blood pressure calculation step and the blood pressure correction step may be further included.

One embodiment of the blood pressure measurement method according to the present invention further includes a continuous measurement information input step of inputting the continuous measurement time and the measurement period of the blood pressure of the continuous blood pressure value tracking step, inputted to the continuous measurement information input step The pulse pressure detection step, the sensing blood pressure calculation step, the blood pressure correction step, and the continuous blood pressure value tracking step are repeated as a measurement period of blood pressure, and the continuous blood pressure value tracking step is performed on the same actual average blood pressure value during the input continuous measurement time. Systolic blood pressure value (rSBP), the actual diastolic blood pressure value (rDBP) can be continuously calculated and tracked.

The present invention pressurizes the blood vessels of the radial artery, and measures the reaction pressure according to the pressurization, and corrects this through not only the elastic modulus of the skin and blood vessels but also the pulse pressure attenuation rate, the blood vessels and the stiffness of the skin to accurately measure the blood pressure of the subject. It has an effect.

The present invention can accurately measure the blood pressure of the subject continuously for a certain period of time at regular intervals to check the daily blood pressure fluctuations through the monitoring of normal blood pressure or continuous blood pressure measurement at 1 minute intervals, or to change due to respiration or other factors. It is possible to monitor blood pressure more stably by securing a minute variation or average value for 10 seconds for blood pressure.

The present invention can measure the blood pressure continuously comfortably during sleep, and by measuring the blood pressure of the emergency patient transported to the emergency car continuously to check the blood pressure value change according to the patient to cope with the urgent situation It has the effect of making it possible.

1 is a bottom perspective view showing an embodiment of a blood pressure measuring apparatus according to the present invention.

Figure 2 is a block diagram showing an embodiment of a blood pressure measuring apparatus according to the present invention.

Figure 3 is a graph showing a change in the pulse pressure value according to the pressure value pressed by the pressing unit in the blood pressure measuring device according to the present invention.

Figure 4 is a graph showing the amount of pulse wave changes in the pulse period of the heart in the blood pressure measuring apparatus according to the present invention.

5 is a flow chart showing an embodiment of a blood pressure measuring method according to the present invention.

Figure 6 is a flow chart illustrating a blood vessel identification step in the blood pressure measurement method according to the invention.

* Description of the major symbols in the drawings *

1: blood pressure measurement body 2: wearing band member

2a: first band portion 2b: second band portion

2c: male velcro tape 2d: female velcro tape

10: pressurization unit 20: sensor unit

30: blood pressure calculation unit 40: blood pressure correction unit

50: correction factor calculation unit 60: continuous blood pressure value tracking operation unit

70: output control unit

S100: blood vessel identification step S110: pulse pressure measurement process

S120: Pulse pressure comparison process S130: Pressurizing part positioning process

S200: pulse pressure detection step S300: sensing blood pressure calculation step

S310: correction factor calculation step S400: blood pressure correction step

S500: Continuous measurement information input step S600: Continuous blood pressure value tracking step

Hereinafter, the present invention will be described in more detail.

When described in detail with reference to the accompanying drawings a preferred embodiment of the present invention. Prior to the detailed description of the invention, the terms or words used in the specification and claims described below should not be construed as limiting in their usual or dictionary meanings. Therefore, the embodiments described in the specification and the drawings shown in the drawings are only one of the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various modifications that can be replaced at the time of the present application It should be understood that there may be equivalents and variations.

1 is a bottom perspective view showing an embodiment of a blood pressure measuring apparatus according to the present invention, and shows an example including a wearing band member (2) that can be carried out by wearing any one of the wrist, upper arm, lower arm.

Referring to FIG. 1, the blood pressure measuring apparatus according to the present invention may include a blood pressure measuring body 1 having a pressing part 10 for pressing a measuring part to measure a pulse pressure on a lower surface thereof.

The blood pressure measuring body 1 may be provided with a wearing band member (2) to be worn on any one of the wrist, upper arm, lower arm, the wearing band member (2) of the blood pressure measuring body (1) It may include a first band portion (2a) provided on one side to surround a portion of the wearing portion, the second band portion (2b) provided on the other side of the blood pressure measurement body (1) surrounding the remaining portion of the wearing portion.

A male velcro tape 2c is provided on one side of the first band portion 2a and the second band portion 2b, and the other side of the first band portion 2a and the second band portion 2b is provided with the male velcro tape 2c. It is taken as an example that the velcro tape 2d detachable from the velcro tape 2c is provided.

The first band part 2a and the second band part 2b are detachably coupled to each other in addition to the male velcro tape 2c and the arm velcro tape 2d so that the blood pressure measuring body 1 is worn on a worn portion. It will be apparent that the present invention can be modified in various other embodiments which can be easily released in a worn state.

Inside the blood pressure measurement body 1 may be provided with a sensor unit 20 for detecting the pressure value pressed by the pressing unit 10 and the pressing unit 10 and the pulse pressure at the pressed measurement site.

Blood pressure measuring apparatus according to the present invention may be manufactured in a form that the subject to be directly worn and used, such as the blood pressure measuring body (1), in addition to the measuring robot that allows the measurement person to measure in a sitting or supine state Obviously, the present invention may be embodied in various forms known in the art to measure blood pressure of a subject.

The sensor unit 20 is used in a tonometry method that directly presses the blood vessel in the vertical direction to measure the reaction pressure at this time and analyzes the pulse wave showing the change in the blood pressure and the pressure value through the vessel. Note that the detailed description of the sensor is omitted.

The sensor unit 20 detects the position of the measurement vessel in which the largest and clearest signal is input when pressing the skin of the measurement site to position the pressing unit 10 in the measurement vessel. An example is an array sensor mounted on the rear surface.

The measurement blood vessel is a blood vessel in which the largest and clearest signal is input when the skin is pressed by the pressing unit 10 and is a position where the pulse wave can be detected most accurately.

The array sensor may be composed of a plurality of pressure sensors for measuring the pressure applied by the pressing unit 10 and the pulse pressure of the blood vessel, the pressure sensor is preferably a piezoresistive pressure sensor. Pressing force is the pressure applied to the measuring vessel. The array sensor may be implemented as a pressure sensor whose number and area are appropriately changed according to the area to be measured and the size of the corresponding artery.

The piezoresistive pressure sensor may be composed of a diaphragm for converting external pressure into stress and a part for converting vibration generated from the diaphragm into an electrical signal so as to simultaneously measure the pressing force and the pulse pressure according to the pressing force. The piezoresistive pressure sensor is preferably selected to measure the pressing force and pulse pressure within the linear section.

The blood vessel checking step (S100) of searching the position of the measurement vessel and placing the array sensor on the measurement vessel includes the pressurizing unit 10 until the pressure sensor in the center of the array sensor receives the largest and clearest signal. By repeating the operation of checking the location of the blood vessel by pressing the skin of the subject to a certain pressing force to be made so that the measurement blood vessel is located in the center of the pressurizing unit 10, which is a method for measuring blood pressure according to the present invention To explain in more detail.

The sensor unit 20 confirms that the blood vessel that is the largest and clearest signal is input at the center of the pressing unit 10 when the blood vessel is pressurized by the measuring unit, that is, the pressing unit 10, and is measured by the measuring vessel. While pressing the skin of the site, the highest pressure value that generates the highest pulse pressure is detected. In addition, the highest pulse pressure value is detected along with the highest pressure value.

According to a preferred embodiment of the present invention, the highest pressure value was measured by a tonometry method for observing a change in pulse pressure appearing in a blood vessel according to a pressure value applied to the predetermined measurement site. Here, the maximum pulse pressure value means the pulse pressure value when the maximum pressure value is obtained.

3 is a graph showing a change in pulse pressure value according to the pressure value pressed by the pressurizing unit 10 in the blood pressure measuring device according to the present invention. Referring to FIG. It becomes the highest pulse pressure value PPmax which is the pulse pressure value at the time of obtaining this highest pressure value.

Referring to FIG. 2 again, the highest pressure value and the highest pulse pressure value detected by the sensor unit 20 may be measured by a blood pressure value of the subject, that is, an average blood pressure value, a pulse pressure value, a systolic blood pressure value, a diastolic blood pressure value, or the like. The blood pressure calculation unit 30 calculates the blood pressure value.

That is, the sensing blood pressure value includes a sensing average blood pressure value sMBP, a sensing pulse pressure value sPP, a sensing systolic blood pressure value sSBP, and a sensing diastolic blood pressure value sDBP.

The blood pressure calculating unit 30 checks the highest pressure value as the sensing average blood pressure value (sMBP) of the subject to be sensed by the sensor unit 20, and detects the highest pulse pressure value by the sensor unit 20. Check the measured pulse pressure value (sPP) of the measured subject, and the remaining blood pressure parameters, that is, the sensing systolic blood pressure value (sSBP), the sensing diastolic blood pressure value (sDBP) to calculate a general blood pressure value formula such as Equation 1 and Equation 2 below. Calculate through

[Equation 1]

MBP = DBP + PP / 3

[Equation 2]

PP = SBP-DBP

Equations 1 and 2 are well known equations, and more detailed description thereof will be omitted.

The blood pressure values calculated by the blood pressure calculator 30, that is, the sensing average blood pressure value sMBP, the sensing pulse pressure value sPP, the sensing systolic blood pressure value sSBP, and the sensing diastolic blood pressure value sDBP are the blood pressure correction unit 40. ) Is corrected by the elastic modulus of the skin and blood vessels at the measurement site, the rate of decay of pressure, and the stiffness of blood vessels and skin.

That is, the blood pressure correcting unit 40 measures the sensing average blood pressure value sMBP, sensing pulse pressure value sPP, sensing systolic blood pressure value sSBP, and sensing diastolic blood pressure value sDBP calculated by the blood pressure calculating unit 30. The actual blood pressure value, that is, the actual mean blood pressure value (rMBP) and the actual pulse pressure value (rPP), are corrected by using the elasticity coefficient (k) of the skin and blood vessels at the measurement site, the rate of attenuation of pulse pressure (a), and the stiffness of the blood vessels and skin (u). ), The actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) are calculated.

The blood pressure correcting unit 40 calculates an actual pulse pressure value rPP and an actual average blood pressure value rMBP through Equations 4 and 5 below, and calculates a general blood pressure value, that is, Equation 1 and the above. Equation 2 is used to calculate the actual systolic blood pressure value rSBP and the actual diastolic blood pressure value rDBP.

[Equation 4]

rPP = k × sPP + a × sPP + (sPP + sMBP) × u + C

[Equation 5]

rMBP = k × sMBP + sMBP × u + C

C: mean blood pressure correction constant (0.1mmHg ~ 0.9mmHg)

The C is obtained by the difference between the mean blood pressure value (rMBP) finally obtained according to the present invention and the mean blood pressure value (MBP) obtained from A-Line, an invasive blood pressure measurement result considered as the gold standard of blood pressure measurement. Any value between 0.1 mmHg and 0.9 mmHg can be used.

On the other hand, the blood pressure measuring apparatus according to the present invention may further include a correction factor calculation unit 50 for calculating the elastic modulus of the skin and blood vessels, the pulse pressure reduction rate, the stiffness of the blood vessels and skin.

The sensor unit 20 detects the vertical movement displacement dx of the skin according to the pressure value dP applied to the measurement site, and corrects the vertical movement displacement of the skin with the pressure value detected by the sensor unit 20. By transmitting to the calculation unit 50, the correction factor calculation unit 50 to calculate the elastic modulus of the skin and blood vessels.

For example, the correction factor calculator 50 calculates an elastic modulus k of skin and blood vessels through Equation 6 below.

[Equation 6]

In addition, the correction factor calculator 50 is an example of calculating the pulse pressure reduction ratio (a) through the following equation (7).

When the applied pressure recognized as the sensing mean blood pressure value (sMBP) is over a certain range and appears in a high pressure band, the sensing pulse pressure value (sPP) is attenuated by the external pressure to be pressed, and the attenuation rate is noticeable. The attenuation rate (a) is different for each individual, and precisely controls the pressurizing unit 10 to change the amount of change of the sensing pulse pressure value sPP (dpp), that is, the change of the pressing force of the pressurizing unit 10 per hour (dAp). It may be calculated through the derivative of the change amount dpp of the sensing pulse pressure value sPP relative to the change amount dAp, which is expressed by Equation 7 below.

[Equation 7]

α: sensor adaptation coefficient

Α is obtained by using a regression equation obtained between a sensor value and a real value having a linear relationship or a secondary relationship at the time of correction before using the sensor unit 20, which is a sensor used in a known tonometry method. It is applied selectively by the type of the part 20, and it turns out that it is a known sensor adaptation coefficient calculated when employing and using the sensor part 20 in a well-known tonometric method.

In addition, the stiffness (u) of the skin is calculated as the inverse of the pressure compliance (b) of the blood vessels, that is, 1 / b, the pressure compliance (b) of the blood vessels is the time taken to expand the blood vessels by the pressure shown in Figure 4 and As can be seen from the graph showing the change amount of the pulse wave in the pulse period of the heart in the blood pressure measuring device according to the present invention, it is possible to confirm the parameters h1 and t1 for confirming the pressure compliance (b) of the blood vessel.

On the other hand, the blood pressure measuring apparatus according to the present invention measures the pulse wave for a predetermined time in the state of maintaining the highest pressing force applied to the measurement site in the pressing unit 10, by measuring the sensing pulse pressure value per beat the same actual average blood pressure It further comprises a continuous blood pressure value tracking operation unit 60 for continuously calculating and tracking the actual systolic blood pressure value (rSBP), the actual diastolic blood pressure value (rDBP) by the blood pressure calculation unit 30 and the blood pressure correction unit 40 on the value. can do.

In addition, the blood pressure measuring apparatus according to the present invention may further include a continuous measurement information input unit for inputting the measurement period and the continuous measurement time in the continuous blood pressure value tracking operation unit 60.

The continuous blood pressure value tracking operation unit 60 is inputted after the operation of continuously measuring the blood pressure for a predetermined time, that is, during the input continuous measurement time (5 to 10 seconds) in a state where the actual average blood pressure value rMBP is fixed. After the measurement cycle, the process of measuring the original blood pressure again is applied, that is, the sensor unit 20 again detects the highest pressure value and the highest pulse pressure value for deriving the maximum pressure value, whereby the blood pressure calculator 30 and The blood pressure correcting unit 40 newly calculates the actual average blood pressure value rMBP, and maintains the maximum applied pressure applied to the measurement site in the pressing unit 10 while fixing the changed actual mean blood pressure value rMBP. The pulse wave is measured for a predetermined time in one state, and the sensing pulse pressure value is measured for each beat to continuously calculate the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) on the same actual mean blood pressure value (rMBP). The repeat is capable of pre-set time of the continuous blood pressure measurement method of repeating a cycle period of time set to the continuous blood pressure measurement for the implementation of the by.

For example, it is possible to implement a continuous blood pressure measurement method of measuring continuous blood pressure for 10 seconds during 10 second time at 1 minute intervals and again measuring new blood pressure values for 10 seconds at 1 minute intervals.

In addition, the blood pressure measuring apparatus according to the present invention is a pulse pressure change graph detected by the sensor unit 20, the sensing blood pressure value calculated by the blood pressure calculation unit 30, the actual blood pressure value calculated by the blood pressure correction unit 40 The apparatus may further include an output controller 70 outputting a graph of a change in the actual blood pressure value continuously detected by the continuous blood pressure value tracking calculator 60 on a screen.

The output control unit 70 may output the result value obtained in the blood pressure measuring apparatus according to the present invention, that is, the pulse pressure value sensed by the sensor unit 20, the sensing blood pressure value, the actual blood pressure value, etc., respectively, as a graph or a numerical value. It is.

On the other hand, Figure 5 is a flow chart showing an embodiment of the blood pressure measuring method according to the present invention with reference to Figure 5, the blood pressure measuring method according to the present invention by pressing the measurement site for measuring the pulse pressure of the measurement target at the measurement site Sensing blood pressure calculation step (S300) for calculating the maximum blood pressure value to generate the highest pressure value and the maximum pressure value to generate the maximum pressure value (S200), the maximum pressure value and the maximum pulse pressure derived from the pulse pressure detection step (S200) The blood pressure correction step (S400) of calculating the actual blood pressure value by correcting the sensed blood pressure value through the elastic modulus of the skin and blood vessels of the measurement site, the pulse pressure reduction rate, and the stiffness of the blood vessel and skin.

The sensing blood pressure calculation step (S300) is to calculate the sensing blood pressure value by the blood pressure calculating unit 30, confirming the highest pressure value as the sensing average blood pressure value (sMBP) of the subject, and measuring the maximum pulse pressure value. The blood pressure calculating unit calculates a sensing systolic blood pressure value sSBP and a sensing diastolic blood pressure value sDBP through a general blood pressure value calculation formula such as Equation 1 and Equation 2 by checking the subject's sensing pulse pressure value sPP. As described in detail in the embodiment of 30), the description is omitted as a redundant description.

The blood pressure measuring method according to the present invention is performed after the sensing blood pressure calculation step (S300) and before the blood pressure correction step (S400) and calculates a correction factor calculating step of calculating elastic modulus of the skin and blood vessels, pulse pressure attenuation rate, blood vessel and skin stiffness ( S310), wherein the correction factor calculation step (S310) detects the vertical displacement of the skin according to the amount of change in the pressure value applied to the measurement site, the skin and blood vessels by the amount of change in the pressure value and the vertical displacement of the skin The process of calculating the elastic modulus of the pressure, the process of calculating the pulse pressure decay rate through the derivative of the change amount of the sensing pulse pressure value (sPP) compared to the change amount of the pressure force (dAp), the pressure of the vessel, which is the time taken for the vessel to expand by pressure Deriving compliance and calculating the stiffness of the skin as the inverse of the pressure compliance of the blood vessels.

The correction factor calculation step (S310) is calculated by Equation 6 and Equation 7 in the correction factor calculation unit 50, and thus, the description of the correction factor calculation unit 50 will be omitted. Put it.

In addition, the blood pressure correction step (S400) is calculated by the blood pressure correction unit 40 to calculate the actual pulse pressure value (rPP) and the actual average blood pressure value (rMBP) by the equations (4) and (5), and The blood pressure correcting unit 40 calculates an actual systolic blood pressure value rSBP and an actual diastolic blood pressure value rDBP using a general blood pressure value calculation formula, that is, Equation 1 and Equation 2 above. As described above, the description is omitted as a duplicate description.

In addition, the blood pressure measuring method according to the present invention is a pressure unit for measuring the pulse pressure in the measurement vessel by searching for the position of the measurement vessel where the largest and clearest signal is inputted when pressing the skin of the measurement region before the pulse pressure detection step (S200). It may further comprise a blood vessel identification step (S100) for positioning (10).

The blood vessel checking step (S100) is such that the measurement blood vessel is positioned in the center of the pressure sensor, that is, the pressure sensor located at the center of the array sensor mounted on the back of the pressing unit 10.

It is confirmed that the plane of the pressing unit 10 is a surface in contact with the skin of the subject to be measured, and the rear surface of the pressing unit 10 is opposite to the plane of the pressing unit 10.

Figure 6 is a flow chart showing the blood vessel check step (S100) in the blood pressure measurement method according to the present invention, referring to Figure 6 the blood vessel check step (S100) measures the pressure unit 10 mounted on the rear of the array sensor A pulse pressure measurement process (S110) and a pulse pressure measurement process (S110), which are located at a plurality of points estimated as the positions of blood vessels, apply the same pressing force at each point, and store the positions of the pulse pressure and the positions of the respective points when the pressing force is applied, respectively. The pressure unit 10 is moved to a point corresponding to the pulse pressure selected in the pulse pressure comparison process (S120) and the pulse pressure comparison process (S120) by comparing the pulse pressures at each point measured at the pulse pressure comparison process (S120). Pressing part positioning process (S130) to include.

The blood vessel checking step (S100) applies the same pressing force to each point while moving the pressing unit 10 to a plurality of points, senses the pulse pressure at the corresponding point, and generates the largest signal by comparing the pulse pressure at each point. That is, by placing the blood vessel in which the largest pulse pressure is generated at the same pressing force in the center of the pressing unit 10 to be able to measure the blood pressure value of the measurement target more accurately.

Referring back to Figure 5, the blood pressure measurement method according to the present invention measures the pulse wave for a predetermined time in the state of maintaining the maximum pressing force applied to the measurement site after the blood pressure correction step (S400), the sensing pulse pressure value for each beat A continuous blood pressure value which is measured and continuously calculated by tracking the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) in the sensing blood pressure calculation step (S300) and the blood pressure correction step (S400). It may further include a tracking step (S600).

In addition, the blood pressure measurement method according to the present invention further comprises a continuous measurement information input step (S500) for inputting the continuous measurement time and the measurement period of the blood pressure in the continuous blood pressure value tracking step (S600), the continuous measurement information input Repeating the pulse pressure detection step (S200), the sensing blood pressure calculation step (S300), the blood pressure correction step (S400), the continuous blood pressure value tracking step (S600) as the measurement cycle of the blood pressure input to the step (S500), Continuous blood pressure value tracking step (S600) continuously calculates and tracks the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) on the same actual average blood pressure value during the input continuous measurement time.

When the blood pressure measuring method according to the present invention finishes the operation of continuously measuring the blood pressure for a predetermined time, that is, during the input continuous measurement time (5 to 10 seconds) while fixing the first actual average blood pressure value (rMBP) of the subject to be measured. As an example, an input measuring cycle is applied to the process of measuring the original blood pressure again after 1 minute, that is, the maximum pressure value and the maximum pressure value are derived again by the pulse pressure detecting step S200, and thus the sensing blood pressure calculation step ( S300), the new average blood pressure value (rMBP) is newly calculated in the blood pressure correction step (S400), that is, the fixed maximum actual blood pressure value (rMBP) is fixed, that is, the highest applied to the measurement site in the pressure unit 10 The pulse wave is measured for a predetermined time while maintaining the pressing force, and the sensing pulse pressure value is measured for each beat to open the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) on the same actual average blood pressure value. Repeat this to ever calculated by group may repeat a cycle period of time set to the continuous blood pressure measurement of the set time.

For example, it is possible to implement a continuous blood pressure measurement method of measuring continuous blood pressure for 10 seconds during 10 second time at 1 minute intervals and again measuring new blood pressure values for 10 seconds at 1 minute intervals.

In addition, the blood pressure measurement method according to the present invention, the pulse pressure change graph detected by the pulse pressure detection step (S200), the sensing blood pressure value calculated in the sensing blood pressure calculation step (S300), the actual blood pressure value calculated in the blood pressure correction step The method may further include an output step of outputting a graph of a change in the actual blood pressure value continuously detected in the continuous blood pressure value tracking step (S600).

In the output step, all the result values obtained by the blood pressure measuring method according to the present invention, that is, the pulse pressure value sensed by the sensor unit 20, the sensing blood pressure value, the actual blood pressure value, etc. are output as graphs or numerical values, respectively, to be confirmed on the screen. To be able.

Blood pressure changes in normal people are within a certain range, so check for daily blood pressure fluctuations through normal blood pressure monitoring or continuous blood pressure measurement at 1 minute intervals, or for blood pressure that may change due to breathing or other factors. More stable blood pressure monitoring is possible by securing minute variation or average value for 10 seconds.

Table 1 below shows the average blood pressure, systolic blood pressure, diastolic blood pressure, pulse pressure and non-invasive blood pressure measurement device according to the present invention measured by the invasion method using a catheter for 200 subjects Descriptive statistical analysis table comparing and confirming blood pressure value, systolic blood pressure value, diastolic blood pressure value and pulse pressure value.

In the following Comparative Example 1 is an example of measuring the mean blood pressure value, systolic blood pressure value, diastolic blood pressure value, pulse pressure value in the invasion method using a catheter for 200 subjects, the embodiment is a blood pressure measuring device according to the present invention And the blood pressure measurement method using the same is an example of measuring the average blood pressure value, systolic blood pressure value, diastolic blood pressure value, pulse pressure value.

Parameter		Comparative example	Example	Difference
Average blood pressure (MBP)	Mean	83.95	83.85	0.1
	Standard Deviation (STD)	13.99	13.21
Systolic Blood Pressure (SBP)	Mean	124.20	122.15	2.05
	Standard Deviation (STD)	18.13	17.50
Diastolic Blood Pressure (DBP)	Mean	68.08	66.35	-3.27
	Standard Deviation (STD)	9.53	9.90
Pulse pressure (PP)	Mean	61.12	58.42	2.70
	Standard Deviation (STD)	9.40	9.70

As confirmed in Table 1, invasive blood pressure measuring device according to the present invention and the four factors that determine the measured blood pressure value using the same, that is, mean blood pressure value, systolic blood pressure value, diastolic blood pressure value, pulse pressure value When compared with the mean blood pressure value, systolic blood pressure value, diastolic blood pressure value, and pulse pressure value measured by the method, it was confirmed that the difference in the mean was less than 5.

The error range of the medical precision sphygmomanometer required by the US AANI, etc. should be within the range of 5mmHg for all measurement variables, it can be confirmed that the blood pressure value measured by the blood pressure measuring device and the blood pressure measurement method using the same can satisfy this. .

The present invention pressurizes the blood vessels of the radial artery, and measures the reaction pressure according to the pressurization, and corrects this through not only the elastic modulus of the skin and blood vessels but also the pulse pressure attenuation rate, the blood vessels and the stiffness of the skin to accurately measure blood pressure of the subject have.

The present invention can accurately measure the blood pressure of the subject continuously for a certain period of time at regular intervals to check the daily blood pressure fluctuations through the monitoring of normal blood pressure or continuous blood pressure measurement at 1 minute intervals, or to change due to respiration or other factors. More stable blood pressure monitoring is possible by securing minute fluctuations or average values for 10 seconds of blood pressure.

The present invention can measure the blood pressure continuously comfortably during sleep, and by measuring the blood pressure of the emergency patient transported to the emergency car continuously to check the blood pressure value change according to the patient to cope with the urgent situation It is possible.

The present invention is not limited to the above-described embodiments, and various changes can be made without departing from the gist of the present invention, which is understood to be included in the configuration of the present invention.

Claims (15)

1. Pressurizing unit for pressurizing the measurement site for measuring the pulse pressure, the pressurization value pressurized by the pressurization unit and the sensor unit for detecting the pulse pressure at the pressurized measurement site, the highest pressurization to generate the highest pulse pressure among the pressurized value detected by the sensor unit A blood pressure calculator that calculates a sensing blood pressure value using the value and the highest pulse pressure, and the blood pressure value calculated by the blood pressure calculator is corrected through the elastic modulus of the skin and blood vessels at the measurement site, the pulse pressure attenuation rate, and the stiffness of the blood vessel and the skin. Blood pressure measuring device comprising a blood pressure correction unit for calculating the.
2. The method according to claim 1,

   The blood pressure calculating unit checks the highest pressure value as the sensing average blood pressure value (sMBP) of the measurement subject sensed by the sensor unit, and the maximum pulse pressure value is the sensing pulse pressure value (sPP) of the measurement subject sensed by the sensor unit. The blood pressure measurement device, characterized in that for calculating the sensing average blood pressure value (sMBP) and the sensing pulse pressure value (sPP) to calculate a sensing systolic blood pressure value (sSBP), a sensing diastolic blood pressure value (sDBP).
3. The method according to claim 1,

   Further comprising a correction factor calculation unit for calculating the elastic modulus (K) of the skin and blood vessels, the pulse pressure reduction rate (a), the stiffness of the blood vessels and skin (u),

   The correction factor calculating unit

   

   To calculate the elastic modulus (K) of the skin and blood vessels,

   

   The low pulse pressure attenuation rate (a) is calculated, and the stiffness (u) of the skin is calculated as the inverse of the pressure compliance (b) of the blood vessel, and the pressure compliance (b) of the blood vessel is the time taken for the blood vessel to expand by pressure. Blood pressure measuring device, characterized in that.

   (dP: pressure value, dx: vertical displacement of skin, dAP: change in pressure value, dpp: change in sensing pulse pressure value (sPP), α: sensor adaptation coefficient)
4. The method according to claim 1,

   The pulse wave is measured for a predetermined time in the state of maintaining the maximum pressing force applied from the pressurizing part to the measuring part, and the sensing pulse pressure value is measured for each beat, and the actual systolic pressure is measured by the blood pressure calculating part and the blood pressure compensating part on the same actual average blood pressure value. And a continuous blood pressure value tracking operation unit for continuously calculating and tracking a blood pressure value rSBP and an actual diastolic blood pressure value rDBP.
5. The method according to claim 4,

   The continuous blood pressure value tracking operation unit further comprises a continuous measurement information input unit for inputting the measurement period and the continuous measurement time,

   The continuous blood pressure value tracking operation unit after the operation of continuously measuring the blood pressure during the input continuous measurement time in a fixed state of the actual average blood pressure value (rMBP) after the input measuring cycle again the highest pressure value and the highest pressure Detects the highest pulse pressure value for deriving a value, thereby newly calculating the actual average blood pressure value (rMBP) in the blood pressure calculating section and the blood pressure correcting section, and maintaining the maximum pressure applied to the measurement site in the pressing section. The pulse wave is measured for a predetermined time, and the sensing pulse pressure value is measured for each beat, and the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rDBP) are converted to the blood pressure calculator and the blood pressure correction unit on the same actual average blood pressure value (rMBP). It is characterized by repeating the measurement of continuous blood pressure for a predetermined time by repeating the continuous calculation at a predetermined time period. Blood pressure measurement device with.
6. The method according to claim 3,

   The blood pressure correction unit calculates the actual pulse pressure value rPP and the actual average blood pressure value rMBP through Equations 4 and 5 below, and the actual systolic pressure is converted into the actual pulse pressure value rPP and the actual average blood pressure value rMBP. Blood pressure measuring device, characterized in that for calculating the blood pressure value (rSBP), the actual diastolic blood pressure value (rDBP).

   [Equation 4]

   rPP = k × sPP + a × sPP + (sPP + sMBP) × u + C

   [Equation 5]

   rMBP = k × sMBP + sMBP × u + C

   k: modulus of elasticity

   a: pulse pressure reduction rate

   u: stiffness of blood vessels and skin

   C: mean blood pressure correction constant (0.1mmHg ~ 0.9mmHg)
7. The method according to claim 1,

   The sensor unit is a blood pressure measurement, characterized in that the array sensor which is mounted on the back of the pressing unit to search the position of the measurement vessel that the largest and clear signal is input when pressing the skin of the measurement site to position the pressing unit in the measurement vessel Device.
8. A pulse pressure sensing step of deriving a maximum pressure value and a maximum pulse pressure for generating a maximum pulse pressure at the measurement site by pressing a measurement site for measuring a pulse pressure of a measurement subject;

   A sensing blood pressure calculation step of calculating a sensing blood pressure value using the highest pressure value and the highest pulse pressure derived in the pulse pressure detecting step;

   And a blood pressure correction step of calculating the actual blood pressure value by correcting the sensed blood pressure value through the elastic modulus of the skin and blood vessels of the measurement site, the pulse pressure decay rate, and the stiffness of the blood vessel and skin.
9. The method according to claim 8,

   In the sensing blood pressure calculation step, the highest pressure value is determined as the sensing average blood pressure value (sMBP) of the measurement target, and the maximum pulse pressure value is determined by the sensing pulse pressure value (sPP) of the measurement target. A blood pressure measurement method comprising calculating a sensing diastolic blood pressure value (sDBP).
10. The method according to claim 8,

    After the sensing blood pressure calculation step is performed before the blood pressure correction step and further comprises a correction factor calculation step for calculating the elastic modulus of the skin and blood vessels, the pulse pressure reduction rate, the stiffness of blood vessels and skin,

    The correction factor calculation step is the equation

    

    To calculate the elastic modulus (K) of the skin and blood vessels,

    

    The low pulse pressure attenuation rate (a) is calculated, and the stiffness (u) of the skin is calculated as the inverse of the pressure compliance (b) of the blood vessel, and the pressure compliance (b) of the blood vessel is the time taken for the blood vessel to expand by pressure. Blood pressure measuring method, characterized in that.

    (dP: pressure value, dx: vertical displacement of skin, dAP: change in pressure value, dpp: change in sensing pulse pressure value (sPP), α: sensor adaptation coefficient)
11. The method according to claim 10,

    The blood pressure correction step is to calculate the actual pulse pressure value (rPP) and the actual average blood pressure value (rMBP) through the following equations (4) and (5), the actual pulse pressure value (rPP) and the actual average blood pressure value (rMBP) Calculating a systolic blood pressure value (rSBP) and an actual diastolic blood pressure value (rDBP).

    [Equation 4]

    rPP = k × sPP + a × sPP + (sPP + sMBP) × u + C

    [Equation 5]

    rMBP = k × sMBP + sMBP × u + C

    k: modulus of elasticity

    a: pulse pressure reduction rate

    u: stiffness of blood vessels and skin

    C: mean blood pressure correction constant (0.1mmHg ~ 0.9mmHg)
12. The method according to claim 8,

    When the pressure on the skin of the measurement site prior to the pressure detection step to search for the location of the measurement vessel that the largest and clear signal is inputted further comprising the step of identifying the blood vessel to locate the pressure unit for measuring the pulse pressure in the measurement vessel How to measure blood pressure.
13. The method according to claim 12,

    The blood vessel confirmation step,

    A pulse pressure measuring process of placing a pressure sensor mounted on a rear surface of the array sensor at a plurality of points estimated as the positions of the measurement vessels, applying the same pressing force at each point, and storing the pulse pressure reacting when the pressing force is applied and the positions of the respective points;

    A pulse pressure comparison process of selecting a pulse pressure having the largest pulse pressure by comparing the pulse pressures at each point measured in the pulse pressure measurement process; And

    And a pressurizing unit positioning process of moving the pressurizing unit to a point corresponding to the selected pulse pressure in the comparing pulse pressure.
14. The method according to claim 8,

    After the blood pressure correction step, the pulse wave is measured for a predetermined time in the state of maintaining the maximum pressure applied to the measurement site, and the sensing pulse pressure value is measured for each beat, and the actual systolic blood pressure value (rSBP) and the actual diastolic device are measured on the same actual average blood pressure value. And a continuous blood pressure value tracking step of continuously calculating and tracking a blood pressure value (rDBP) as the sensing blood pressure calculation step and the blood pressure correction step.
15. The method according to claim 14,

    The continuous blood pressure value tracking step and the continuous measurement information input step of inputting the measurement period of the blood pressure further comprises the step, the pulse pressure detection step, the sensing blood pressure as the measurement period of the blood pressure input to the continuous measurement information input step The calculation step, the blood pressure correction step and the continuous blood pressure value tracking step are repeated, and the continuous blood pressure value tracking step includes the actual systolic blood pressure value (rSBP) and the actual diastolic blood pressure value (rSBP) on the same actual average blood pressure value during the input continuous measurement time. blood pressure measurement method characterized by continuously calculating and tracking rDBP).

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