WO2017042767A1 - Method and device for monitoring the state of a patient with neurodegenerative disease - Google Patents

Method and device for monitoring the state of a patient with neurodegenerative disease Download PDF

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Publication number
WO2017042767A1
WO2017042767A1 PCT/IB2016/055851 IB2016055851W WO2017042767A1 WO 2017042767 A1 WO2017042767 A1 WO 2017042767A1 IB 2016055851 W IB2016055851 W IB 2016055851W WO 2017042767 A1 WO2017042767 A1 WO 2017042767A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
monitoring
keyboard
neurodegenerative disease
state
Prior art date
Application number
PCT/IB2016/055851
Other languages
French (fr)
Inventor
Marcos ODENS
José Angel GONZÁLEZ GILL
Juan Bosco GUEVARA PERÉZ
Ulises GAMALIER MADERO
Yino Xavier SEGURA MARTINEZ
Ricardo Antonio DE LEVANTE
Original Assignee
Universidad Tecnológica De Panamá
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Tecnológica De Panamá filed Critical Universidad Tecnológica De Panamá
Publication of WO2017042767A1 publication Critical patent/WO2017042767A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6897Computer input devices, e.g. mice or keyboards
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1126Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4082Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia

Definitions

  • the present invention relates to methods and devices for monitoring neurodegenerative diseases. Specifically, with devices with which the users interact through graphic interfaces.
  • neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases, among others, have a range of diagnostic techniques such as Biomarkers, Magnetic Resonance Imaging (MRI), Single-Photon Emission Computerized Tomography (SPECT) and Positron Emission Tomography (PET), Cerebrospinal Fluid (CSF) and plasma biochemical markers, biochemical studies in plasma, but these techniques are very expensive for patients and are invasive mechanisms for the patient.
  • MRI Magnetic Resonance Imaging
  • SPECT Single-Photon Emission Computerized Tomography
  • PET Positron Emission Tomography
  • CSF Cerebrospinal Fluid
  • the present invention consists of a non-invasive diagnosis method based on the creation of a recreational application aimed at capturing data from the patient such as the time to complete an action, or the time in which he or she responds to a stimulus through the use of keystroke biometrics. These responses shall be captured by means of the use of a user interface.
  • Patent application 12/117,389 applied for by Dan details a user interface but is used for processing communication problems and in an invasive manner.
  • Patent application number 10/813,796 applied for by Leinbach discloses graphic interfaces towards the user for the processing of problems such as dementia, autism or similar.
  • This document details a non-invasive method which is used for monitoring users with neurodegenerative diseases, using a biometric technique of the keyboard or keystrokes by means of an electronic device equipped with input means to collect the data obtained from the patient on interacting with a videogame shown on the touchscreen of the electronic device so that the monitoring is performed through playing recreational activities.
  • positive messages can also be emitted to the user at the time when an activity is completed or the monitoring is started, all the data and times are stored for later evaluation by qualified personnel.
  • Said data can be used to assess the advance of the disease so that it is possible to start, pause, cancel or modify the prescription of medication or treatments aimed at improving the patient.
  • the method of the invention can be implemented in a device to monitor the advance of neurodegenerative diseases in users, which has a touchscreen to perform the monitoring.
  • Figure 1 Shows a view of the electronic device used to perform the method of the invention.
  • Figure 2. Shows a view of the electronic device used to perform the method of the invention dismantled, wherein the screen and its housing is observed.
  • Figure 3. Shows a view of the electronic device used to perform the method of the invention dismantled, wherein the assembly of the screen in the socket of the device body is observed.
  • Figure 4 Shows a rear view of the electronic device used to perform the method of the invention.
  • FIG. 5 Shows a flow diagram of the method of the invention.
  • DETAILED DESCRIPTION OF THE INVENTION To perform the method of the invention of one aspect of the invention and detailed in figure 5 and designed to monitor the patient, who is a previously registered user who wants to be monitored in case he/she is in an initial phase of a neurodegenerative disease, the patient interacts with a user interface shown on a touchscreen (2) embedded in a socket (5) of the main body of an electronic device (1) object of a second aspect of the invention; where said screen (2) is observed, among others, in figures 1 or 3, so that it allows the input of data in the electronic device (1) and the display of data from said touchscreen (2).
  • the patient is registered as a user after entering user credentials in credentials panels of the electronic device (1) comprising a user credentials panel and a user password credentials panel.
  • Said interaction allows performing the method for monitoring the state of a patient with neurodegenerative disease of one aspect of the invention since, once recreational activities start, which may comprise activities such as videogames shown on the screen (2) and the user performs them, the electronic device (1), by means of a processing unit, records biometric patterns of keystrokes on a keyboard of the touchscreen (2) whilst said recreational activities are performed and saves the biometric result in a database, which will contain the biometric behaviour information of the patient's keystrokes to generate a medical record of advance of the disease.
  • recreational activities start which may comprise activities such as videogames shown on the screen (2) and the user performs them
  • the electronic device (1) by means of a processing unit, records biometric patterns of keystrokes on a keyboard of the touchscreen (2) whilst said recreational activities are performed and saves the biometric result in a database, which will contain the biometric behaviour information of the patient's keystrokes to generate a medical record of advance of the disease.
  • a biometric result is generated, which corresponds to a state of the patient, from the biometric patterns of keystrokes on the keyboard of the touchscreen (2) in response to stimuli generated by the videogame where the biometric result is generated by means of synchronized input capture on the keyboard and displays on the touchscreen (2); where said biometric patterns of keystrokes on the keyboard of the touchscreen (2) comprise at least one of: pressure exerted on the screen (2), total keystroke time, average keystroke speed, partial keystroke speed, time between keystrokes, total keystroke rate and partial keystroke rate.
  • All the necessary data and instructions for executing the videogame can be uploaded in the electronic device (1) by means of a port (4), as shown in figure 4, which serves as programming data input and can also serve as power input or by means of a connection (3) of the electronic device (1) for the connection designed to recharge the power and transfer data as shown in figure 2.

Abstract

This document details a method and a device for monitoring the state of a user or patient who is at the start or during the convalescence period of a neurodegenerative disease. The object of the invention described here is based on the capture and processing of biometric data collected by means of a series of sensors, biometric data which correspond to reactions of the patient to audio-visual stimuli displayed on a screen and which allow determining, together with the measurement of the input data of said reactions to the stimuli, a response generated by means of synchronized input capture on the keyboard and displays on the screen. With said response it is possible to generate a monitoring pattern that allows starting, modifying or cancelling a treatment to said neurodegenerative disease.

Description

METHOD AND DEVICE FOR MONITORING THE STATE OF A PATIENT WITH NEURODEGENERATIVE DISEASE
FIELD OF THE INVENTION The present invention relates to methods and devices for monitoring neurodegenerative diseases. Specifically, with devices with which the users interact through graphic interfaces.
BACKGROUND OF THE INVENTION
According to the WHO, neurological disorders such as Parkinson's disease, Alzheimer's disease and dementia will become one of the greatest threats to global public health due to the increase in elderly population. Since the risk of suffering from these diseases considerably increases with age and it is calculated that between 25% and 30% of people who are 85 years old or more suffer from a certain degree of cognitive deterioration. It is expected that between 2015 and 2050, the proportion of the global population over the age of 60 will go from 900 million to 2000 million, which represents an increase from 12% to 22%.
The health problems caused by the high rate of neurodegenerative diseases at in social, ethnic and economic levels and age groups is one of the main threats in productivity for the state, companies, communities and markets. Currently, neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases, among others, have a range of diagnostic techniques such as Biomarkers, Magnetic Resonance Imaging (MRI), Single-Photon Emission Computerized Tomography (SPECT) and Positron Emission Tomography (PET), Cerebrospinal Fluid (CSF) and plasma biochemical markers, biochemical studies in plasma, but these techniques are very expensive for patients and are invasive mechanisms for the patient.
The present invention consists of a non-invasive diagnosis method based on the creation of a recreational application aimed at capturing data from the patient such as the time to complete an action, or the time in which he or she responds to a stimulus through the use of keystroke biometrics. These responses shall be captured by means of the use of a user interface. Patent application 12/117,389 applied for by Dan details a user interface but is used for processing communication problems and in an invasive manner.
Patent application number 10/813,796 applied for by Leinbach discloses graphic interfaces towards the user for the processing of problems such as dementia, autism or similar.
DESCRIPTION OF THE INVENTION
This document details a non-invasive method which is used for monitoring users with neurodegenerative diseases, using a biometric technique of the keyboard or keystrokes by means of an electronic device equipped with input means to collect the data obtained from the patient on interacting with a videogame shown on the touchscreen of the electronic device so that the monitoring is performed through playing recreational activities.
When the interaction is performed, positive messages can also be emitted to the user at the time when an activity is completed or the monitoring is started, all the data and times are stored for later evaluation by qualified personnel.
Said data can be used to assess the advance of the disease so that it is possible to start, pause, cancel or modify the prescription of medication or treatments aimed at improving the patient.
Likewise, the method of the invention can be implemented in a device to monitor the advance of neurodegenerative diseases in users, which has a touchscreen to perform the monitoring.
DESCRIPTION OF THE FIGURES
To complement the description being made and in order to aid towards a better understanding of the characteristics of the invention, in accordance with a preferred example of practical embodiment thereof, a set of drawings is attached as an integral part of said description wherein, with illustrative and non-limiting character, the following has been represented:
Figure 1. Shows a view of the electronic device used to perform the method of the invention. Figure 2. Shows a view of the electronic device used to perform the method of the invention dismantled, wherein the screen and its housing is observed.
Figure 3. Figure 2.- Shows a view of the electronic device used to perform the method of the invention dismantled, wherein the assembly of the screen in the socket of the device body is observed.
Figure 4. Shows a rear view of the electronic device used to perform the method of the invention.
Figure 5. Shows a flow diagram of the method of the invention. DETAILED DESCRIPTION OF THE INVENTION To perform the method of the invention of one aspect of the invention and detailed in figure 5 and designed to monitor the patient, who is a previously registered user who wants to be monitored in case he/she is in an initial phase of a neurodegenerative disease, the patient interacts with a user interface shown on a touchscreen (2) embedded in a socket (5) of the main body of an electronic device (1) object of a second aspect of the invention; where said screen (2) is observed, among others, in figures 1 or 3, so that it allows the input of data in the electronic device (1) and the display of data from said touchscreen (2).
The patient is registered as a user after entering user credentials in credentials panels of the electronic device (1) comprising a user credentials panel and a user password credentials panel.
Said interaction allows performing the method for monitoring the state of a patient with neurodegenerative disease of one aspect of the invention since, once recreational activities start, which may comprise activities such as videogames shown on the screen (2) and the user performs them, the electronic device (1), by means of a processing unit, records biometric patterns of keystrokes on a keyboard of the touchscreen (2) whilst said recreational activities are performed and saves the biometric result in a database, which will contain the biometric behaviour information of the patient's keystrokes to generate a medical record of advance of the disease.
To do this, a biometric result is generated, which corresponds to a state of the patient, from the biometric patterns of keystrokes on the keyboard of the touchscreen (2) in response to stimuli generated by the videogame where the biometric result is generated by means of synchronized input capture on the keyboard and displays on the touchscreen (2); where said biometric patterns of keystrokes on the keyboard of the touchscreen (2) comprise at least one of: pressure exerted on the screen (2), total keystroke time, average keystroke speed, partial keystroke speed, time between keystrokes, total keystroke rate and partial keystroke rate. On starting the interaction, i.e. when the videogame starts being displayed on the screen (2) it is possible to emit a sound by means of audio playing means (6)
All the necessary data and instructions for executing the videogame can be uploaded in the electronic device (1) by means of a port (4), as shown in figure 4, which serves as programming data input and can also serve as power input or by means of a connection (3) of the electronic device (1) for the connection designed to recharge the power and transfer data as shown in figure 2.

Claims

1. Method for monitoring the state of a patient with neurodegenerative disease by means of a device comprising:
• a touchscreen designed to allow the display of data and comprising a keyboard designed to allow the data input in the device,
• a user credentials panel, and
• a user password credentials panel, wherein the display of data on the screen comprises a videogame and the method comprises: · performing an interaction between the patient registered as user in response to the videogame by means of the keyboard,
• generating biometric patterns of keystrokes on the touchscreen keyboard, and
• generating a biometric result, which corresponds to a state of the patient from the biometric patterns of keystrokes on the touchscreen keyboard in response to stimuli generated by the videogame where the biometric result is generated by means of synchronized input capture on the keyboard and displays on the screen.
2. Method for monitoring the state of a patient with neurodegenerative disease, according to claim 1 , additionally comprising: · entering user credentials in the credentials panels, and
• generating a display of data on the screen when an identity is verified of the user from the user credentials.
3. Method for monitoring the state of a patient with neurodegenerative disease, according to claim 1 , where the biometric patterns of keystrokes on the keyboard of the touchscreen (2) comprise at least one of: total typing time, average typing speed, maximum typing speed, time between keystrokes, total typing rhythm and partial typing rhythm.
4. Method for monitoring the state of a patient with neurodegenerative disease, according to claim 1 , where the biometric result is stored in a database.
5. Device for monitoring the status of a patient with neurodegenerative disease, said device comprising a main body and a processing unit whereto the following are associated:
• a touchscreen designed to show audio-visual content and allow data input by means of interaction therewith, and
• audio playing means designed to generate audio, where the processing unit is operational to generate a biometric result, which corresponds to a state of the patient from biometric patterns of keystrokes on the touchscreen keyboard in response to stimuli generated by a videogame shown on the screen where the biometric result is generated by means of synchronized input capture on the keyboard and displays on the screen.
6. Device for monitoring the status of a patient with neurodegenerative disease, according to claim 5, additionally comprising a port and a connection designed to allow programming data input and power input.
PCT/IB2016/055851 2016-07-20 2016-09-30 Method and device for monitoring the state of a patient with neurodegenerative disease WO2017042767A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PA9124701 2016-07-20
PA91247 2016-07-20

Publications (1)

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WO2017042767A1 true WO2017042767A1 (en) 2017-03-16

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10314521B2 (en) 2017-09-19 2019-06-11 International Business Machines Corporation User condition evaluation system through touch screen device usage pattern change
CN111329444A (en) * 2020-02-14 2020-06-26 桂林医学院附属医院 Parkinson's disease condition monitoring system based on virtual keyboard

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690325B1 (en) * 2005-07-12 2014-04-08 Sandy Helene Straus Sensory input devices, sensory output devices, and automatic systems, methods, and apparatuses for at least one of mass measurement, evaluation, or communication
US20160117940A1 (en) * 2012-09-12 2016-04-28 Lingraphicare America Incorporated Method, system, and apparatus for treating a communication disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690325B1 (en) * 2005-07-12 2014-04-08 Sandy Helene Straus Sensory input devices, sensory output devices, and automatic systems, methods, and apparatuses for at least one of mass measurement, evaluation, or communication
US20160117940A1 (en) * 2012-09-12 2016-04-28 Lingraphicare America Incorporated Method, system, and apparatus for treating a communication disorder

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10314521B2 (en) 2017-09-19 2019-06-11 International Business Machines Corporation User condition evaluation system through touch screen device usage pattern change
CN111329444A (en) * 2020-02-14 2020-06-26 桂林医学院附属医院 Parkinson's disease condition monitoring system based on virtual keyboard

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