WO2016095685A1 - Pneumatic constant pressure continuous liquid feeding device and method - Google Patents

Pneumatic constant pressure continuous liquid feeding device and method Download PDF

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Publication number
WO2016095685A1
WO2016095685A1 PCT/CN2015/095752 CN2015095752W WO2016095685A1 WO 2016095685 A1 WO2016095685 A1 WO 2016095685A1 CN 2015095752 W CN2015095752 W CN 2015095752W WO 2016095685 A1 WO2016095685 A1 WO 2016095685A1
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WO
WIPO (PCT)
Prior art keywords
constant pressure
pressure tank
tank
liquid
valve
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PCT/CN2015/095752
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French (fr)
Chinese (zh)
Inventor
应跃斌
江海燕
陈静
杨少烽
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应跃斌
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Publication of WO2016095685A1 publication Critical patent/WO2016095685A1/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04F—PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
    • F04F1/00—Pumps using positively or negatively pressurised fluid medium acting directly on the liquid to be pumped
    • F04F1/06—Pumps using positively or negatively pressurised fluid medium acting directly on the liquid to be pumped the fluid medium acting on the surface of the liquid to be pumped

Definitions

  • the invention belongs to the technical field of liquid transportation, and particularly relates to a pneumatic constant pressure liquid continuous feeding device and method.
  • the filter unit is widely used in water treatment, chemical industry and food industry.
  • the filtration technology has been developed and applied as never before.
  • the pore size of the liquid filtration membrane it can be divided into reverse osmosis, ultrafiltration, nanofiltration, and microfiltration.
  • reverse osmosis is used for injection water production, ultrafiltration for protein concentration and buffer system replacement, nanofiltration for virus filtration, microfiltration for sterilization filtration and particle filtration;
  • the material is compounded or surface-modified, and a deep filtration membrane and an ion exchange filtration membrane have been developed.
  • the former is mainly used for efficient clarification of the feed liquid, and the latter is mainly used for fine purification of the protein.
  • Operating pressure is an important process parameter for all filtration unit operations, and any commercial filtration material must provide the user with a range of pressures for normal operation.
  • the operating pressure is too low, the liquid permeability is low, and the working efficiency is lowered; if the operating pressure is too high, the concentration polarization is easily caused, and the liquid permeability is also lowered. If the operating pressure exceeds a certain range, the filter medium is broken down. Feed fluid contamination, so providing optimized constant pressure for filtration unit operation is important to increase filtration efficiency. The importance of constant pressure to filtration is particularly evident in the biopharmaceutical sector.
  • the centrifugal driving, peristaltic pump or diaphragm pump for the liquid driving pressure of the filtering unit in industrial production is mainly used.
  • the pump can provide a stable flow rate, but since the filtration is a dynamic process, as the throughput increases, the filter membrane becomes clogged and the system pressure will become higher and higher. Therefore, the filter system with a higher degree of automation will filter.
  • the pressure at the feed port acts as a feedback signal to control the speed of the pump to maintain the operating pressure constant or within a certain range.
  • the object of the present invention is to provide a pneumatic constant pressure liquid continuous feeding device and method without pulse, high constant pressure precision, wide working pressure range, low shear force and continuous production, and at the same time, to meet the product cleanliness in the biopharmaceutical field.
  • the special requirement is that a disposable plastic bag can be placed in the feeding device of the invention for convenient cleaning.
  • the pneumatic constant pressure liquid continuous feeding device comprises a first constant pressure tank, and the upper wall or the side wall of the first constant pressure tank is provided with a ventilation duct communicating with the inner chamber of the first constant pressure tank, and the outer end portion of the ventilation duct passes
  • An intake valve is installed on the intake pipe connected to the three-way, and an emptying valve is connected to the exhaust pipe through the three-way communication, and the bottom wall of the tank wall of the first constant pressure tank is provided with the first constant pressure tank inner cavity
  • a first inlet conduit communicating with the inner chamber of the first constant pressure tank is disposed on the communicating outlet conduit, the upper wall or the side wall, and the first inlet conduit and the outlet conduit are each provided with a valve;
  • the liquid conduit has one of the following two external components:
  • the first external connecting member on the first inlet conduit is configured such that a ventilation duct communicating with the inner chamber of the second constant pressure tank is disposed on the upper wall or the side wall of the second constant pressure tank, and the outer end portion of the ventilation conduit is passed
  • An intake valve is installed on the intake pipe connected to the three-way, and an emptying valve is connected to the exhaust pipe through the three-way communication, and the bottom wall of the tank wall of the second constant pressure tank is provided with the second constant pressure tank inner cavity
  • a second liquid inlet conduit communicating with the inner chamber of the second constant pressure tank is disposed on the outlet conduit, the upper wall or the side wall, and the second inlet conduit and the outlet conduit are respectively provided with a valve, the first constant pressure tank
  • the outer end portions of the first and second liquid inlet conduits on the second constant pressure tank are connected by a three-way connection, and the outer ends of the first constant pressure tank and the second constant pressure tank are connected by a three-way joint;
  • the second external component on the first inlet conduit has a structure in which a third inlet pipe and a ventilation conduit are disposed on the upper wall or the side wall of the buffer tank, and a valve is installed on the third inlet pipe, and the ventilation conduit is externally
  • An intake valve is installed on the intake pipe through which the end is connected through the three-way, and an emptying pipe is connected to the exhaust pipe through the three-way communication, and the first inlet conduit provided with the valve passes through the bottom wall of the buffer tank and the buffer tank
  • the inner chamber is connected, and the buffer tank and the upper wall or the side wall of the first constant pressure tank are connected to the buffer tank and the inner chamber of the first constant pressure tank through the pressure equalizing tube, and the equalizing tube is provided with a valve.
  • the upper inner wall of the first constant pressure tank, the second constant pressure tank and the buffer tank are respectively provided with a loop hook or a circumferentially distributed hook, and the upper end opening of the clean plastic bag is inlaid or hung on the hook, and the plastic bag is
  • the bottom wall is provided with a rigid and hollow cannula communicating with the inner cavity of the plastic bag, the outer diameter of the cannula and the second
  • the constant pressure tank, the first constant pressure tank or/and the inner diameter of the hollow connecting pipe on the bottom wall of the buffer tank are matched, and the inner diameter of the cannula is matched with the outer diameter of the external plug, and the inner diameter of the cannula and the outer diameter of the external plug
  • a sealing ring is arranged between the insertion tube and the external plug through the inner and outer diameters, and is connected by a sealing ring, and the outlet conduit is connected to the external plug.
  • the external plug and the connecting pipe are connected by a flange or a screw connection or a quick connector.
  • the first constant pressure tank and the outer end of the liquid outlet conduit on the second constant pressure tank are connected to the third through-connected conduit of the tee after the three-way connection; or the outer end of the liquid outlet conduit A filter is connected to the part.
  • the first constant pressure tank and the inlet pipe on the second constant pressure tank share a compressed body source, and the pressure of the compressed gas provided by the compressed body source can be adjusted according to the process requirements.
  • the first constant pressure tank and the intake pipe on the buffer tank share a compressed body source, and the pressure of the compressed gas provided by the compressed body source can be adjusted according to the process requirements.
  • the above-mentioned continuous feeding method of the pneumatic constant pressure liquid continuous feeding device has the first constant pressure tank and the second constant pressure tank liquid continuous feeding device: when the first constant pressure tank is pressurized, the first The second constant pressure tank is continuously fed with a compressed gas of a certain pressure. When the second constant pressure tank is fed at a normal pressure, the first constant pressure tank is continuously supplied with a compressed gas of a certain pressure, and the first constant pressure tank is filled with the first constant pressure tank.
  • the two constant pressure tanks are alternately fed and fed to achieve continuous feeding of the pneumatic constant pressure liquid; or the liquid continuous feeding device having the first constant pressure tank and the buffer tank: the tank is periodically fed and The first constant pressure tank is periodically replenished, and a compressed gas of a certain pressure is supplied from the first constant pressure tank and continuously supplied, thereby continuously feeding the liquid of the pneumatic constant pressure. .
  • the liquid feeding mode of the present invention because it is driven by a compressed gas, the liquid does not generate severe enthalpy.
  • the pneumatic liquid feeding mode of the present invention since the air pressure is controlled at a set constant pressure (for example, 2 bar), the fluctuation of the feeding pressure is eliminated compared with the conventional pump feeding; the working pressure during the filtering process does not exceed the preset constant pressure. Eliminates the risk of damage to the membrane due to overpressure.
  • a set constant pressure for example, 2 bar
  • the pneumatic liquid feeding mode of the invention can be promoted according to the sensitivity of the protein in the liquid to oxygen, and the inert gas such as nitrogen is used to further improve the protection of the protein.
  • the invention realizes continuous feeding by rotating the first constant pressure tank and the second constant pressure tank in turn, or continuously supplies the first constant pressure tank through the buffer tank to realize continuous feeding, so that the filtering work can be continuously performed.
  • the production efficiency is high; compared with the servo transmission system with pressure feedback function, the control is simpler, the manufacturing cost is low, and the running cost is low.
  • the invention hangs a clean plastic bag in the tank of the first constant pressure tank, the second constant pressure tank or the first constant pressure tank and the buffer tank, and the tank body is not cleaned before and after each production, and only the circulation pump is used. It can be used for circulating cleaning of pipes or conduits that come into contact with liquids. The cleaning time is short and the cleaning cost is low.
  • the special joint design enables the pressure operation in the one-time production process.
  • the invention is suitable for liquid filtration feeding in the field of biotechnology, and the invention is particularly suitable for virus filtration of protein solution having special requirements for constant pressure feeding in the field of biopharmaceutical, and unidirectional flow ultrafiltration concentration of high pressure and low flow rate. In the production process.
  • Figure 1 is a schematic illustration of one of the structures of the present invention.
  • Figure 2 is a schematic illustration of the second structure of the present invention.
  • FIG 3 is a schematic view showing the structure of a first constant pressure tank, a second constant pressure tank and a buffer tank of the present invention.
  • Fig. 4 is an enlarged view of a portion A of Fig. 3;
  • Figure 5 is a schematic illustration of a first portion of a particular structure of the structure of the present invention.
  • Figure 6 is a schematic view of a second portion of a specific structure of one of the structures of the present invention.
  • 5 and 6 are combined diagrams showing a specific structure of one of the structures of the present invention.
  • Figure 7 is a schematic diagram of the pressure signal of the pressure sensor of the present invention.
  • FIG. 1 A first figure
  • the pneumatic constant pressure liquid continuous feeding device comprises a first constant pressure tank 10, and the upper wall or the side wall of the first constant pressure tank 10 is provided with a ventilation duct 11 communicating with the inner cavity of the first constant pressure tank 10, and the ventilation duct 11
  • An intake valve 15 is mounted on the intake pipe 16 communicating with the tee 14 at the outer end portion, and an evacuation valve 13 is disposed on the evacuation pipe 12 communicating through the tee 14 to the bottom of the tank wall of the first constant pressure tank 10.
  • the wall is provided with a liquid outlet conduit 40 communicating with the inner cavity of the first constant pressure tank 10, and the upper wall or the side wall is provided with a first liquid inlet conduit 17 communicating with the inner cavity of the first constant pressure tank 10, the first liquid inlet
  • the conduits 17 and the outlet conduits 40 are each provided with valves 18, 41; the first inlet conduit 17 has one of the following two external components:
  • the first external connecting member on the first inlet conduit 17 is configured such that the upper wall or the side wall of the second constant pressure tank 20 is provided with a ventilation duct 21 communicating with the inner chamber of the second constant pressure tank 20, and the ventilation duct 21
  • the intake pipe 25 is connected to the intake pipe 26 that communicates with the tee 24 at the outer end portion, and the exhaust valve 23 is connected to the exhaust pipe 22 that communicates through the tee 24, and the bottom of the tank wall of the second constant pressure tank 20 is installed.
  • the wall is provided with a liquid outlet conduit 45 communicating with the inner cavity of the second constant pressure tank 20, and a second inlet conduit 27 disposed on the upper wall or the side wall and communicating with the inner chamber of the second constant pressure tank 20, the second liquid inlet Valves 28 and 44 are disposed on the conduit 27 and the outlet conduit 45, and the outer ends of the first and second inlet conduits 17, 27 on the first constant pressure tank 10 and the second constant pressure tank 20 pass through the tee 29 Connecting, the first constant pressure tank 10 and the outer end portions of the liquid outlet conduits 45, 40 on the second constant pressure tank 20 are connected by a three-way 43;
  • the second external component on the first inlet conduit 17 is constructed such that a third inlet tube 51 and a venting conduit 55 are disposed on the upper wall or side wall of the buffer tank 50, and a valve is mounted on the third inlet tube 51. 52.
  • the intake pipe 56 is connected to the intake pipe 80 of the outer end of the ventilation duct 55 through the three-way 57, and the exhaust valve 58 is connected to the exhaust pipe 59 that communicates through the three-way 57.
  • the valve 18 is provided.
  • An inlet conduit 17 communicates with the inner chamber of the buffer tank 50 through the bottom wall of the buffer tank 50, and the buffer tank 50 and the upper wall or side wall of the first constant pressure tank 10 pass through the pressure equalizing tube 53 and the buffer tank 50 and the first constant
  • the inner chamber of the pressure tank 10 is in communication, and the pressure equalizing tube 53 is provided with a valve 54.
  • the upper inner wall of the second constant pressure tank 20, the first constant pressure tank 10 and the buffer tank 50 is provided with a U-shaped hook or a circumferentially distributed hook 103.
  • the upper end opening of the plastic bag 60 is inlaid or hung on the hook.
  • 103, on the bottom wall of the clean (for example, after sterilization) plastic bag 60 is provided with a rigid and hollow cannula 61 communicating with the inner cavity of the plastic bag 60, the outer diameter of the cannula 61 and the second constant pressure
  • the tank 20, the first constant pressure tank 10 or/and the inner diameter of the hollow connecting pipe 101 on the bottom wall of the buffer tank 50 are fitted, and the inner diameter of the cannula 61 is matched with the outer diameter 72 of the external plug 70, and the inner diameter of the cannula 61
  • a sealing ring 73 is disposed between the outer diameter of the external plug 70, and the outer plug is coupled to the external plug through the inner and outer diameters, and is connected by a sealing ring.
  • the external plug 70 and the connecting pipe 101 described above are connected by a flange 102, 71 or a screw connection or a quick connector.
  • the first constant pressure tank 10 and the third end connection conduit 42 of the tee 43 connected to the outer end of the outlet conduits 40, 45 on the second constant pressure tank 20 through the tee 43 are connected with a virus removal.
  • a jig or filter; or a virus removing jig or filter is attached to the outer end of the liquid outlet conduit 40.
  • the first constant pressure tank 10 and the intake pipes 16, 26 on the second constant pressure tank 20 share a compressed gas source 81, and the pressure of the compressed gas supplied from the compressed gas source 81 can be adjusted according to process requirements, for example, The gas pressure is 2 bar.
  • the first constant pressure tank 10 described above shares one with the intake pipes 16, 80 on the buffer tank 50, and the pressure of the compressed gas supplied from the compressed gas source 81 can be adjusted according to the process demand, for example, the gas pressure is 2 bar.
  • the above continuous feeding method of the pneumatic constant pressure liquid continuous feeding device is: in the liquid continuous feeding device having the first constant pressure tank 10 and the second constant pressure tank 20: when the first constant pressure tank 10 is constantly pressurized During the feeding, the second constant pressure tank 20 is continuously fed with a compressed gas of a certain pressure. When the second constant pressure tank 20 is fed at a normal pressure, the first constant pressure tank 10 is continuously fed with a compressed gas of a certain pressure.
  • the first constant pressure tank 10 and the second constant pressure tank 20 are alternately fed and fed to realize continuous feeding of the liquid of a constant constant pressure; or the liquid continuous feeding device having the first constant pressure tank 10 and the buffer tank 50 Medium: periodically feeding from the buffer tank 50 and periodically replenishing the first constant pressure tank 10, and the first constant pressure tank 10 is supplied with a compressed gas of a certain pressure and continuously supplied to achieve a pneumatic constant pressure. The liquid is continuously fed.
  • the top cover of the first constant pressure tank 10 and the second constant pressure tank 20 is opened, and the clean plastic bags 60 are respectively hung on the hooks 103 of the first constant pressure tank 10 and the second constant pressure tank 20 and pressed by the annular pressure block 104.
  • the plastic bag 60 cannula 61 is respectively passed downward from the hollow connecting tube 101 at the bottom of the first constant pressure tank 10 and the second constant pressure tank 20, and is inserted into the upper portion of the external plug 70, and the external plug 70 is externally connected.
  • the flange 71 is connected to the flange 102 on the connecting pipe 101, and the lower portion of the external plug 70 is connected to the liquid outlet conduits 40, 45 and connected to the liquid outlet conduit 42 through the tee 43.
  • the outer end of the liquid outlet conduit 42 is connected to the filter.
  • the top cover of the first constant pressure tank 10 and the second constant pressure tank 20 is closed, and the first inlet conduit 17 and the second inlet conduit 27 are connected to the inlet conduit 31 through the tee 29, and the outer end of the inlet conduit 31 is
  • the liquid supply bag 30 or the liquid outlet of the liquid storage tank is connected to close all the valves, the ventilation pipes 26 and 16 are externally connected to the compressed gas source 81, and after opening the valves 18 and 13, the liquid storage bag 30.
  • the liquid level of the first constant pressure tank 10 reaches a certain height (high limit)
  • the valves 18 and 13 are closed, and the valves are sequentially opened.
  • 15 and 41 in the case where the pressure of the compressed gas of the compressed gas source 81 is 2 bar, the liquid in the first constant pressure tank 10 is stably filtered through the liquid outlet conduits 40 and 42 into the filter;
  • the valves 28, 23 are opened, so that the pressure formed by the liquid in the liquid storage bag 30 or the liquid storage tank automatically flows into the second constant pressure tank 20, and the second constant pressure tank 20 is liquid.
  • the surface reaches a certain height (high limit), the valves 28, 23 are closed and the valve 25 is opened for use, and the liquid level of the first constant pressure tank 10 reaches a certain height (low limit), the valve 44 is opened, and the valves 41, 15 are closed.
  • the first constant pressure tank 10 stops supplying liquid
  • the second constant pressure tank 20 takes over the liquid supply, realizes continuous continuous liquid supply and filtration, and then opens the valve 13 to evacuate the pressure in the first constant pressure tank 10, and then opens
  • the valve 18 automatically flows into the first pressure that causes the liquid in the liquid storage bag 30 or the liquid storage tank to be separated by the height difference.
  • the constant pressure tank 10 after the liquid level of the first constant pressure tank 10 reaches a certain height (high limit), then closes the valves 18, 13, opens the valve 15 for pressurization, and the liquid in the liquid storage bag 30 or the liquid storage tank is all After the output, the new liquid storage bag 30 or the liquid storage tank can be replaced under normal pressure without affecting the continuous feeding; of course, if the cleaning requirement of the liquid is not high, or the first constant pressure tank 10 and the second constant pressure If the cleaning of the inner wall of the can 20 is not high, the components such as the plastic bag 60 and its associated cannula 61 may not be used.
  • the top cover of the first constant pressure tank 10 and the buffer tank 50 is opened, and the clean plastic bags 60 are respectively hung on the hooks 103 of the first constant pressure tank 10 and the buffer tank 50, and are pressed by the annular pressing block 104 to press the plastic bag 60.
  • the cannula 61 is respectively passed downward from the hollow connecting tube 101 at the bottom of the first constant pressure tank 10 and the buffer tank 50, and is inserted into the upper portion of the external plug 70, and the flange 71 of the external plug 70 and the connecting tube 101 are connected.
  • the flange 102 is connected, the lower portion of the external plug 70 is connected to the liquid outlet conduit 40, and the outer end of the liquid outlet conduit 40 is connected to the filter to close the top cover of the first constant pressure tank 10 and the buffer tank 50, first
  • the inlet tanks 80 and 16 of the constant pressure tank 10 and the buffer tank 50 are connected to the external compressed gas source 81 through a three-way connection, and the outer end of the inlet conduit 31 is connected with the liquid supply bag 30 or the liquid outlet of the liquid storage tank, and all of them are closed.
  • the valves 52, 18 and 13 are opened, the pressure formed by the height difference between the liquid in the liquid storage bag 30 or the liquid storage tank first flows into the buffer tank 50 and then flows into the first constant pressure tank 10, and waits for the first constant pressure tank.
  • the liquid level reaches a certain height (high limit), the valves 52, 18 and 13 are closed, and the valves 15 and 41 are sequentially opened.
  • the first constant pressure tank 10 is under the constant pressure of the compressed gas source of the compressed gas source 81 of 2 bar.
  • the liquid inside is stably passed into the filter through the outlet conduit 41 for filtration; during the operation of the first constant pressure tank 10, the valves 52, 58 are opened to make the liquid in the liquid storage bag 30 or the liquid storage tank high in height difference.
  • the formed pressure automatically flows into the buffer tank 50, and the liquid level of the buffer tank 50 reaches a certain height (high limit), the valves 52, 58 are closed, the valve 56 is opened to pressurize, the pressure of the buffer tank 50 is stabilized, the valve 56 is closed, and the valve 54 is opened. Eliminating the slight pressure that may exist between the buffer tank 50 and the first constant pressure tank 10 When the liquid level in the first constant pressure tank 10 reaches a certain height (low limit), the valve 18 is opened, so that the pressure formed by the height difference of the liquid in the buffer tank 50 automatically flows into the first constant pressure tank 10, and is closed after the liquid replacement is completed.
  • the valves 18, 54 open the valve 58, evacuate the air pressure in the buffer tank 50, open the valve 52, and enter the next feeding cycle, thereby performing an uninterrupted continuous liquid supply and filtration according to the cycle; the liquid storage bag 30 or After the liquid in the liquid storage tank is completely output, the new liquid storage bag 30 or the liquid storage tank can be replaced under normal pressure without affecting the continuous feeding; of course, if the cleaning requirement of the liquid liquid is not high, or the first If the inner wall cleaning requirements of the constant pressure tank 10 and the second constant pressure tank 20 are not high, the plastic bag 60 and its associated cannula 61 and the like may not be used.
  • a small prototype which can be automatically operated (see Figs. 5 and 6) is produced, and automatic continuous feeding under stable pressure is realized, and the practicability of the present invention is verified.
  • the pressure of the first constant pressure tank 10 is monitored in real time using the pressure sensor 201, and the pressure of the second constant pressure tank 20 is monitored in real time using the pressure sensor 211, and is monitored in real time using the pressure sensor 221.
  • the inlet pressure of the filter 222; the upper limit and the lower limit of the liquid level of the first constant pressure tank 10 are monitored using the upper level sensor 202 and the lower level sensor 203, and the second constant pressure is monitored using the upper level sensor 212 and the lower level sensor 213
  • the upper and lower limits of the tank 20 are.
  • the automation controller is composed of the following components: using the OMRON small PLC 230 (including the analog expansion module) according to the received pressure and level signals of the first constant pressure tank 10, the second constant pressure tank 20, and the pressure signal of the filter 222, Automatically send action commands (via relay groups 240-247) to solenoid valve 15 (control intake of first constant pressure tank 10), solenoid valve 13 (control exhaust of first constant pressure tank 10), solenoid valve 25 (control Intake of the second constant pressure tank 20, solenoid valve 23 (control of exhaust of the second constant pressure tank 20), solenoid valve 231 (for controlling opening and closing of the pneumatic diaphragm valve 18), and solenoid valve 232 (for control) Opening and closing of the pneumatic diaphragm valve 41, solenoid valve 233 (for controlling opening and closing of the pneumatic diaphragm valve 28), solenoid valve 234 (for controlling opening and closing of the pneumatic diaphragm valve 44); display and control using the Weiluntong touch screen 235 Operating state; power is supplied to
  • the PLC 230 transmits a signal to open the electromagnetic valve 233 (ie, opens the pneumatic diaphragm valve 28), and the liquid liquid enters the second constant pressure tank 20 from the liquid storage bag 30 by gravity; Constant voltage within two liquid feed tank 20 level rises To contact the upper level sensor 212, the upper level sensor 212 feeds back a signal to the PLC 230, the PLC 230 transmits a signal to close the solenoid valve 233 (ie, closes the pneumatic diaphragm valve 28), and the PLC 230 transmits a signal to close the solenoid valve 23, transmitting a signal to turn on the electromagnetic
  • the valve 25 the compressed air enters the second constant pressure tank 20 in a short time and is balanced to be equal to the air pressure in the first constant pressure tank 10, and the second constant pressure tank 20 waits for filtration; when the liquid liquid in the first constant pressure tank 10 The position is lowered to the lower level sensor 203 as the filter progresses
  • the solenoid valve 232 is closed (ie, the pneumatic diaphragm valve 41 is closed), and after 2 seconds, the PLC 230 transmits a signal to open the solenoid valve 13, the first constant pressure tank 10 is released from pressure, and the pressure sensor 201 feeds back the pressure in the first constant pressure tank 10 and the outside. After the atmospheric pressure is equal, the PLC 230 transmits a signal to open the solenoid valve 231 (i.e., opens the pneumatic diaphragm valve 18), and the liquid enters the first constant pressure tank 10 from the liquid storage bag 30 by gravity; thus, the filtration operation of the system completes one cycle.
  • the filtration operation can be automatically and continuously performed while the feed in the reservoir 30 is processed, or before artificially terminating from the touch screen 235, and the pressure at the inlet of the filter 222 is maintained relatively constant.
  • the pressure signal data of the pressure sensors 201, 211, 221 can be displayed and saved in real time through a touch screen or connected to a computer.
  • the pressure signals of the pressure sensors 201, 211, 221 are shown in Figure 7 during typical operation.
  • the first stage is that the first constant pressure tank 10 is being filtered, the second constant pressure tank 20 is pressurized to be filtered; the second stage is that the first constant pressure tank 10 is lower than the liquid level lower limit, and the feeding is stopped.
  • the second constant pressure tank 20 takes over the feeding;
  • the third stage is the first constant pressure tank 10 is pressurized, the second constant pressure tank 20 is filtering the feeding;
  • the fourth stage is the first constant pressure tank 10 After the material is finished, pressurized, the second constant pressure tank 20 is filtering the feed;
  • the fifth stage is for the first constant pressure tank 10 to be filtered, the second constant pressure tank 20 is filtering the feed;
  • the sixth stage is the second constant pressure tank 20 medium liquid is lower than the lower limit of liquid level, stop feeding and exhaust pressure release, first constant pressure tank 10 takes over feeding;
  • 7 stage is second constant pressure tank 20 normal pressure feeding, first constant pressure tank 10 is filtering feeding In the 8th stage, the second constant pressure tank 20 is fed, pressurized, the first constant pressure tank 10 is filtering the feed;
  • the 9th stage pressurizes the second constant pressure tank 20 to be filtered, and the first constant pressure tank 10 is being In the filtration feeding;
  • the 10th stage is that the first constant pressure tank 10 is lower than the liquid level
  • the two-point liquid level sensor of the present invention can use an ultrasonic level sensor or a load cell to continuously and accurately monitor the liquid volume in the first constant pressure tank 10 and the second constant pressure tank 20.
  • the feed mode can be switched to vacuum feed and pump feed in addition to gravity feed.

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  • Chemical Kinetics & Catalysis (AREA)
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Abstract

A pneumatic constant pressure continuous liquid feeding device and method. The device comprises a first constant pressure tank (10). A ventilating guide pipe (11) communicated with an inner cavity of the first constant pressure tank (10) is arranged on the upper wall or side wall of the first constant pressure tank (10). An air inlet valve (15) is mounted on an air inlet pipe (16) communicated with a tee joint (14) at the outer end part of the ventilating guide pipe (11), and an emptying valve (13) is mounted on an emptying pipe (12) communicated with the tee joint (14). A liquid outlet guide pipe (40) communicated with the inner cavity of the first constant pressure tank (10) is arranged on the bottom wall of the tank wall of the first constant pressure tank (10), a first liquid inlet guide pipe (17) communicated with the inner cavity of the first constant pressure tank (10) is arranged on the upper wall or the side wall of the first constant pressure tank (10), and valves (18, 41) are respectively arranged on the first liquid inlet guide pipe (17) and the liquid outlet guide pipe (40). A second constant pressure tank (20) is connected to the first liquid inlet guide pipe (17), and continuous feeding is realized by means of in-turn feeding of the first constant pressure tank (10) and the second constant pressure tank (20); or a buffer tank (50) is connected to the first liquid inlet guide pipe (17), and continuous feeding is realized in a manner of periodically supplying materials to the first constant pressure tank (10) by means of the buffer tank (50).

Description

气动恒压的液体连续送料装置及方法Pneumatic constant pressure liquid continuous feeding device and method 技术领域Technical field
本发明属于液体输送技术领域，特指一种气动恒压的液体连续送料装置及方法。The invention belongs to the technical field of liquid transportation, and particularly relates to a pneumatic constant pressure liquid continuous feeding device and method.
背景技术Background technique
过滤单元广泛应用于水处理、化工、食品工业，近几十年新兴的生物技术领域中，过滤技术更是得到了前所未有的发展与应用。根据液体过滤膜的孔径不同可分为反渗透、超滤、纳滤、微滤。在生物技术领域，反渗透应用于注射水生产，超滤用于蛋白质浓缩和缓冲体系置换，纳滤主要用于除病毒过滤，微滤主要用于除菌过滤和颗粒过滤；近年来对过滤膜材质进行复合设计或表面修饰，发展出了深层过滤膜与离子交换过滤膜，前者主要用于料液的高效澄清，后者主要应用于蛋白质精细纯化。The filter unit is widely used in water treatment, chemical industry and food industry. In the emerging biotechnology field in recent decades, the filtration technology has been developed and applied as never before. According to the pore size of the liquid filtration membrane, it can be divided into reverse osmosis, ultrafiltration, nanofiltration, and microfiltration. In the field of biotechnology, reverse osmosis is used for injection water production, ultrafiltration for protein concentration and buffer system replacement, nanofiltration for virus filtration, microfiltration for sterilization filtration and particle filtration; The material is compounded or surface-modified, and a deep filtration membrane and an ion exchange filtration membrane have been developed. The former is mainly used for efficient clarification of the feed liquid, and the latter is mainly used for fine purification of the protein.
操作压力是所有过滤单元操作的重要工艺参数，任何一种商业化过滤材料都必须向用户提供正常操作的压力范围。操作压力过低，料液透过率低，降低工作效率；操作压力过高，容易引起浓差极化，同样导致料液透过率降低，如操作压力超过一定范围将导致过滤介质击穿，料液污染，因此为过滤单元操作提供经过优化的恒定压力对于提高过滤效率十分重要。恒定压力对过滤的重要性在生物制药领域的除病毒过滤操作单元尤为明显，在纳滤除病毒过程中，中途压力释放将导致某些滤膜的病毒过滤效率下降，从而增加产品的病毒污染风险[LaCasse D，et al，Impact of process interruption on virus retention of small-virus filters.Bioprocess International，2013，11(10)：34]。 Operating pressure is an important process parameter for all filtration unit operations, and any commercial filtration material must provide the user with a range of pressures for normal operation. The operating pressure is too low, the liquid permeability is low, and the working efficiency is lowered; if the operating pressure is too high, the concentration polarization is easily caused, and the liquid permeability is also lowered. If the operating pressure exceeds a certain range, the filter medium is broken down. Feed fluid contamination, so providing optimized constant pressure for filtration unit operation is important to increase filtration efficiency. The importance of constant pressure to filtration is particularly evident in the biopharmaceutical sector. In the process of nanofiltration, the release of pressure in the middle of the process will result in a decrease in the efficiency of virus filtration of certain membranes, thereby increasing the risk of viral contamination of the product. [LaCasse D, et al, Impact of process interruption on virus retention of small-virus filters. Bioprocess International, 2013, 11(10): 34].
目前工业生产上为过滤单元提供液体驱动压力的主要为离心泵、蠕动泵或隔膜泵。泵可以提供稳定的流速，但由于过滤是一个动态变化的过程，随着处理量的增加，过滤膜逐渐堵塞，系统压力将越来越高，因此一般自动化程度较高的过滤系统都将过滤器进料口的压力作为反馈信号来控制泵的转速，以维持操作压力恒定或在一定范围之内。世界上各大过滤操作整体解决方案供应商都推出了各自的用于生物制药的高度自动化的过滤系统，如Millipore公司的
Figure PCTCN2015095752-appb-000001
Pall公司的AllegroTMMVP，Sartorius公司的
Figure PCTCN2015095752-appb-000002
旭化成公司的PlanovaTMVirus FIltration Controller等，另外配置有恒压功能的自动化层析系统，如GE公司的AKTA系列，也常被用作过滤操作的供料系统。尽管上述自动化系统可以解决过滤操作中的恒压问题，但使用泵作为过滤操作的驱动力存在以下缺点：1、离心泵、蠕动泵产生的机械剪切力对蛋白质具有一定的破坏作用[李国荣等.泵对生物制品工艺的重要影响.流程工业(制药)，2014，10：68]；2、蠕动泵、隔膜泵工作时产生压力脉冲，难以实现较高程度的恒压；3、恒压工作范围小，尤其在低压工作范围，泵的转速较低，由于控制较低的泵转速在技术上较为困难，容易造成系统压力不稳；4、配有伺服系统的设备价格昂贵。At present, the centrifugal driving, peristaltic pump or diaphragm pump for the liquid driving pressure of the filtering unit in industrial production is mainly used. The pump can provide a stable flow rate, but since the filtration is a dynamic process, as the throughput increases, the filter membrane becomes clogged and the system pressure will become higher and higher. Therefore, the filter system with a higher degree of automation will filter. The pressure at the feed port acts as a feedback signal to control the speed of the pump to maintain the operating pressure constant or within a certain range. The world's major filtration solutions total solution providers have launched their own highly automated filtration systems for biopharmaceuticals, such as Millipore's
Figure PCTCN2015095752-appb-000001
Pall's Allegro TM MVP, Sartorius
Figure PCTCN2015095752-appb-000002
Asahi Kasei Company Planova TM Virus FIltration Controller etc. In addition, automated chromatography system configuration of the voltage function, AKTA as GE's series, is also often used as a feed system the filter operation. Although the above-mentioned automatic system can solve the constant pressure problem in the filtration operation, the use of the pump as the driving force of the filtration operation has the following disadvantages: 1. The mechanical shear force generated by the centrifugal pump and the peristaltic pump has a certain destructive effect on the protein [李国荣等Pumps have an important impact on the process of biological products. Process Industry (Pharmaceutical), 2014, 10:68]; 2, peristaltic pump, diaphragm pump generates pressure pulses when working, it is difficult to achieve a higher degree of constant pressure; 3, constant pressure work The range is small, especially in the low-pressure working range, the pump speed is low, because the control of the lower pump speed is technically difficult, it is easy to cause the system pressure to be unstable; 4, the equipment equipped with the servo system is expensive.
发明内容Summary of the invention
本发明的目的是提供一种无脉冲、恒压精度高、工作压力范围广、低剪切力、可连续生产的气动恒压液体连续送料装置及方法；同时为了满足生物制药领域对于产品洁净度的特殊要求，在本发明的送料装置中可放置可抛弃型塑料袋，方便清洗。The object of the present invention is to provide a pneumatic constant pressure liquid continuous feeding device and method without pulse, high constant pressure precision, wide working pressure range, low shear force and continuous production, and at the same time, to meet the product cleanliness in the biopharmaceutical field. The special requirement is that a disposable plastic bag can be placed in the feeding device of the invention for convenient cleaning.
本发明的目的是这样实现的： The object of the invention is achieved in this way:
气动恒压的液体连续送料装置，包括第一恒压罐，第一恒压罐的上壁或侧壁上设置有与第一恒压罐内腔连通的通气导管，通气导管的外端部通过三通连通的进气管上安装有进气阀、通过三通连通的排空管上安装有排空阀，第一恒压罐的罐壁的底壁上设置有与第一恒压罐内腔连通的出液导管、上壁或侧壁上设置有与第一恒压罐内腔连通的第一进液导管，第一进液导管和出液导管上均设置有阀门；其中的第一进液导管上有下述两种外接部件之一：The pneumatic constant pressure liquid continuous feeding device comprises a first constant pressure tank, and the upper wall or the side wall of the first constant pressure tank is provided with a ventilation duct communicating with the inner chamber of the first constant pressure tank, and the outer end portion of the ventilation duct passes An intake valve is installed on the intake pipe connected to the three-way, and an emptying valve is connected to the exhaust pipe through the three-way communication, and the bottom wall of the tank wall of the first constant pressure tank is provided with the first constant pressure tank inner cavity a first inlet conduit communicating with the inner chamber of the first constant pressure tank is disposed on the communicating outlet conduit, the upper wall or the side wall, and the first inlet conduit and the outlet conduit are each provided with a valve; The liquid conduit has one of the following two external components:
第一进液导管上的第一种外接部件的结构是：第二恒压罐的上壁或侧壁上设置有与第二恒压罐内腔连通的通气导管，通气导管的外端部通过三通连通的进气管上安装有进气阀、通过三通连通的排空管上安装有排空阀，第二恒压罐的罐壁的底壁上设置有与第二恒压罐内腔连通的出液导管、上壁或侧壁上设置有与第二恒压罐内腔连通的第二进液导管，第二进液导管和出液导管上均设置有阀门，第一恒压罐与第二恒压罐上的第一、第二进液导管的外端部通过三通连接，第一恒压罐与第二恒压罐上的出液导管的外端部通过三通连接；The first external connecting member on the first inlet conduit is configured such that a ventilation duct communicating with the inner chamber of the second constant pressure tank is disposed on the upper wall or the side wall of the second constant pressure tank, and the outer end portion of the ventilation conduit is passed An intake valve is installed on the intake pipe connected to the three-way, and an emptying valve is connected to the exhaust pipe through the three-way communication, and the bottom wall of the tank wall of the second constant pressure tank is provided with the second constant pressure tank inner cavity a second liquid inlet conduit communicating with the inner chamber of the second constant pressure tank is disposed on the outlet conduit, the upper wall or the side wall, and the second inlet conduit and the outlet conduit are respectively provided with a valve, the first constant pressure tank The outer end portions of the first and second liquid inlet conduits on the second constant pressure tank are connected by a three-way connection, and the outer ends of the first constant pressure tank and the second constant pressure tank are connected by a three-way joint;
第一进液导管上的第二种外接部件的结构是：缓冲罐的上壁或侧壁上设置有第三进液管和通气导管，第三进液管上安装有阀门，通气导管的外端部通过三通连通的进气管上安装有进气阀、通过三通连通的排空管上安装有排空阀，设置有阀门的第一进液导管通过缓冲罐的底壁与缓冲罐的内腔连通，缓冲罐和第一恒压罐的上壁或侧壁通过均压管与缓冲罐和第一恒压罐的内腔连通，均压管上设置有阀门。The second external component on the first inlet conduit has a structure in which a third inlet pipe and a ventilation conduit are disposed on the upper wall or the side wall of the buffer tank, and a valve is installed on the third inlet pipe, and the ventilation conduit is externally An intake valve is installed on the intake pipe through which the end is connected through the three-way, and an emptying pipe is connected to the exhaust pipe through the three-way communication, and the first inlet conduit provided with the valve passes through the bottom wall of the buffer tank and the buffer tank The inner chamber is connected, and the buffer tank and the upper wall or the side wall of the first constant pressure tank are connected to the buffer tank and the inner chamber of the first constant pressure tank through the pressure equalizing tube, and the equalizing tube is provided with a valve.
上述的第一恒压罐、第二恒压罐和缓冲罐的上方内壁上均设置有一圈挂钩或周向均布有挂钩，洁净的塑料袋的上端开口部镶嵌或挂设在挂钩上，塑料袋的底壁上设置有与塑料袋的内腔连通的硬质且中空的插管，插管的外径与第二 恒压罐、第一恒压罐或/和缓冲罐底壁上的中空的连接管的内径相配合，插管的内径与外接插头的外径相配合，插管的内径与外接插头的外径之间设置有密封圈，插管与外接插头通过内外径配合，辅以密封圈连接，所述的出液导管连接在外接插头上。The upper inner wall of the first constant pressure tank, the second constant pressure tank and the buffer tank are respectively provided with a loop hook or a circumferentially distributed hook, and the upper end opening of the clean plastic bag is inlaid or hung on the hook, and the plastic bag is The bottom wall is provided with a rigid and hollow cannula communicating with the inner cavity of the plastic bag, the outer diameter of the cannula and the second The constant pressure tank, the first constant pressure tank or/and the inner diameter of the hollow connecting pipe on the bottom wall of the buffer tank are matched, and the inner diameter of the cannula is matched with the outer diameter of the external plug, and the inner diameter of the cannula and the outer diameter of the external plug A sealing ring is arranged between the insertion tube and the external plug through the inner and outer diameters, and is connected by a sealing ring, and the outlet conduit is connected to the external plug.
上述的外接插头与连接管之间通过法兰盘或螺纹连接部或快装接头连接。The external plug and the connecting pipe are connected by a flange or a screw connection or a quick connector.
上述的第一恒压罐与第二恒压罐上的出液导管的外端部通过三通连接后的三通的第三通连接的导管上连接有过滤器；或出液导管的外端部上连接有过滤器。The first constant pressure tank and the outer end of the liquid outlet conduit on the second constant pressure tank are connected to the third through-connected conduit of the tee after the three-way connection; or the outer end of the liquid outlet conduit A filter is connected to the part.
上述的第一恒压罐与第二恒压罐上的进气管共用一个压缩体源，压缩体源提供的压缩气体的压力根据工艺需求可以调节设定。The first constant pressure tank and the inlet pipe on the second constant pressure tank share a compressed body source, and the pressure of the compressed gas provided by the compressed body source can be adjusted according to the process requirements.
上述的第一恒压罐与缓冲罐上的进气管共用一个压缩体源，压缩体源提供的压缩气体的压力根据工艺需求可以调节设定。The first constant pressure tank and the intake pipe on the buffer tank share a compressed body source, and the pressure of the compressed gas provided by the compressed body source can be adjusted according to the process requirements.
上述的气动恒压的液体连续送料装置的连续送料方法，具有所述的第一恒压罐和第二恒压罐的液体连续送料装置中：当第一恒压罐常压进料时，第二恒压罐通入一定压力的压缩气体连续供料，当第二恒压罐常压进料时，第一恒压罐通入一定压力的压缩气体连续供料，第一恒压罐与第二恒压罐交替地进料和送料，从而实现气动恒压的液体连续送料；或具有所述的第一恒压罐和缓冲罐的液体连续送料装置中：由缓冲罐周期性地进料并周期性地为第一恒压罐补充进料，由第一恒压罐通入一定压力的压缩气体并连续供料，从而实现气动恒压的液体连续送料。。The above-mentioned continuous feeding method of the pneumatic constant pressure liquid continuous feeding device has the first constant pressure tank and the second constant pressure tank liquid continuous feeding device: when the first constant pressure tank is pressurized, the first The second constant pressure tank is continuously fed with a compressed gas of a certain pressure. When the second constant pressure tank is fed at a normal pressure, the first constant pressure tank is continuously supplied with a compressed gas of a certain pressure, and the first constant pressure tank is filled with the first constant pressure tank. The two constant pressure tanks are alternately fed and fed to achieve continuous feeding of the pneumatic constant pressure liquid; or the liquid continuous feeding device having the first constant pressure tank and the buffer tank: the tank is periodically fed and The first constant pressure tank is periodically replenished, and a compressed gas of a certain pressure is supplied from the first constant pressure tank and continuously supplied, thereby continuously feeding the liquid of the pneumatic constant pressure. .
本发明相比现有技术突出且有益的技术效果是：The technical effects of the present invention that are outstanding and beneficial over the prior art are:
1、本发明的液体送料方式，由于是用压缩气体推动，液体不会产生剧烈湍 流，相对常规的泵送料，降低了剪切力对料液中蛋白质的破坏。1. The liquid feeding mode of the present invention, because it is driven by a compressed gas, the liquid does not generate severe enthalpy. The flow, relative to the conventional pump feed, reduces the damage of the protein in the feed by shear forces.
2、本发明的气动液体送料方式，由于气压控制在设定的恒定压力(例如2bar)，相对常规的泵送料，消除了送料压力的波动；过滤过程中工作压力不会超过预设的恒定压力，消除了因过压导致的滤膜破坏风险。2. The pneumatic liquid feeding mode of the present invention, since the air pressure is controlled at a set constant pressure (for example, 2 bar), the fluctuation of the feeding pressure is eliminated compared with the conventional pump feeding; the working pressure during the filtering process does not exceed the preset constant pressure. Eliminates the risk of damage to the membrane due to overpressure.
3、本发明的气动液体送料方式，可以根据料液中蛋白质对氧气的敏感程度，选用氮气等惰性气体进行推动，进一步提高对蛋白质的保护。3. The pneumatic liquid feeding mode of the invention can be promoted according to the sensitivity of the protein in the liquid to oxygen, and the inert gas such as nitrogen is used to further improve the protection of the protein.
4、本发明通过第一恒压罐与第二恒压罐轮流供料实现连续供料，或通过缓冲罐不断地为第一恒压罐补充供料实现连续供料，使得过滤工作可以连续进行，生产效率高；相对具有压力反馈功能的伺服传输系统，控制更加简单，制造成本低，运行成本低。4. The invention realizes continuous feeding by rotating the first constant pressure tank and the second constant pressure tank in turn, or continuously supplies the first constant pressure tank through the buffer tank to realize continuous feeding, so that the filtering work can be continuously performed. The production efficiency is high; compared with the servo transmission system with pressure feedback function, the control is simpler, the manufacturing cost is low, and the running cost is low.
5、本发明在第一恒压罐、第二恒压罐或第一恒压罐与缓冲罐的罐体内挂设清洁的塑料袋，每次生产前后不用对罐体进行清洗，仅用循环泵对接触液体的管道或导管进行循环清洗即可，清洗时间短，清洗成本低，特殊的接头设计使一次性生产工艺中实现带压操作。5. The invention hangs a clean plastic bag in the tank of the first constant pressure tank, the second constant pressure tank or the first constant pressure tank and the buffer tank, and the tank body is not cleaned before and after each production, and only the circulation pump is used. It can be used for circulating cleaning of pipes or conduits that come into contact with liquids. The cleaning time is short and the cleaning cost is low. The special joint design enables the pressure operation in the one-time production process.
6、本发明适用于生物技术领域的料液过滤送料，本发明尤其适用于生物制药领域对恒压送料有特殊要求的蛋白质溶液除病毒过滤，以及高压力、低流速的单向流超滤浓缩等生产工艺中。6. The invention is suitable for liquid filtration feeding in the field of biotechnology, and the invention is particularly suitable for virus filtration of protein solution having special requirements for constant pressure feeding in the field of biopharmaceutical, and unidirectional flow ultrafiltration concentration of high pressure and low flow rate. In the production process.
附图说明DRAWINGS
图1是本发明的结构之一的示意图。Figure 1 is a schematic illustration of one of the structures of the present invention.
图2是本发明的结构之二的示意图。Figure 2 is a schematic illustration of the second structure of the present invention.
图3是本发明的第一恒压罐、第二恒压罐和缓冲罐的结构示意图。3 is a schematic view showing the structure of a first constant pressure tank, a second constant pressure tank and a buffer tank of the present invention.
图4是图3的A部放大图。 Fig. 4 is an enlarged view of a portion A of Fig. 3;
图5是本发明的结构之一具体结构之第一部分示意图。Figure 5 is a schematic illustration of a first portion of a particular structure of the structure of the present invention.
图6是本发明的结构之一具体结构之第二部分示意图。Figure 6 is a schematic view of a second portion of a specific structure of one of the structures of the present invention.
图5、图6合并成为本发明的结构之一的具体结构示意图。5 and 6 are combined diagrams showing a specific structure of one of the structures of the present invention.
图7是本发明的压力传感器的压力信号示意图。Figure 7 is a schematic diagram of the pressure signal of the pressure sensor of the present invention.
具体实施方式detailed description
下面结合附图以具体实施例对本发明作进一步描述，参见图1一图7：The present invention will be further described below with reference to the accompanying drawings in which: FIG.
气动恒压的液体连续送料装置，包括第一恒压罐10，第一恒压罐10的上壁或侧壁上设置有与第一恒压罐10内腔连通的通气导管11，通气导管11的外端部通过三通14连通的进气管16上安装有进气阀15、通过三通14连通的排空管12上安装有排空阀13，第一恒压罐10的罐壁的底壁上设置有与第一恒压罐10内腔连通的出液导管40、上壁或侧壁上设置有与第一恒压罐10内腔连通的第一进液导管17，第一进液导管17和出液导管40上均设置有阀门18、41；其中的第一进液导管17上有下述两种外接部件之一：The pneumatic constant pressure liquid continuous feeding device comprises a first constant pressure tank 10, and the upper wall or the side wall of the first constant pressure tank 10 is provided with a ventilation duct 11 communicating with the inner cavity of the first constant pressure tank 10, and the ventilation duct 11 An intake valve 15 is mounted on the intake pipe 16 communicating with the tee 14 at the outer end portion, and an evacuation valve 13 is disposed on the evacuation pipe 12 communicating through the tee 14 to the bottom of the tank wall of the first constant pressure tank 10. The wall is provided with a liquid outlet conduit 40 communicating with the inner cavity of the first constant pressure tank 10, and the upper wall or the side wall is provided with a first liquid inlet conduit 17 communicating with the inner cavity of the first constant pressure tank 10, the first liquid inlet The conduits 17 and the outlet conduits 40 are each provided with valves 18, 41; the first inlet conduit 17 has one of the following two external components:
第一进液导管17上的第一种外接部件的结构是：第二恒压罐20的上壁或侧壁上设置有与第二恒压罐20内腔连通的通气导管21，通气导管21的外端部通过三通24连通的进气管26上安装有进气阀25、通过三通24连通的排空管22上安装有排空阀23，第二恒压罐20的罐壁的底壁上设置有与第二恒压罐20内腔连通的出液导管45、上壁或侧壁上设置有与第二恒压罐20内腔连通的第二进液导管27，第二进液导管27和出液导管45上均设置有阀门28、44，第一恒压罐10与第二恒压罐20上的第一、第二进液导管17、27的外端部通过三通29连接，第一恒压罐10与第二恒压罐20上的出液导管45、40的外端部通过三通43连接； The first external connecting member on the first inlet conduit 17 is configured such that the upper wall or the side wall of the second constant pressure tank 20 is provided with a ventilation duct 21 communicating with the inner chamber of the second constant pressure tank 20, and the ventilation duct 21 The intake pipe 25 is connected to the intake pipe 26 that communicates with the tee 24 at the outer end portion, and the exhaust valve 23 is connected to the exhaust pipe 22 that communicates through the tee 24, and the bottom of the tank wall of the second constant pressure tank 20 is installed. The wall is provided with a liquid outlet conduit 45 communicating with the inner cavity of the second constant pressure tank 20, and a second inlet conduit 27 disposed on the upper wall or the side wall and communicating with the inner chamber of the second constant pressure tank 20, the second liquid inlet Valves 28 and 44 are disposed on the conduit 27 and the outlet conduit 45, and the outer ends of the first and second inlet conduits 17, 27 on the first constant pressure tank 10 and the second constant pressure tank 20 pass through the tee 29 Connecting, the first constant pressure tank 10 and the outer end portions of the liquid outlet conduits 45, 40 on the second constant pressure tank 20 are connected by a three-way 43;
第一进液导管17上的第二种外接部件的结构是：缓冲罐50的上壁或侧壁上设置有第三进液管51和通气导管55，第三进液管51上安装有阀门52，通气导管55的外端部通过三通57连通的进气管80上安装有进气阀56、通过三通57连通的排空管59上安装有排空阀58，设置有阀门18的第一进液导管17通过缓冲罐50的底壁与缓冲罐50的内腔连通，缓冲罐50和第一恒压罐10的上壁或侧壁通过均压管53与缓冲罐50和第一恒压罐10的内腔连通，均压管53上设置有阀门54。The second external component on the first inlet conduit 17 is constructed such that a third inlet tube 51 and a venting conduit 55 are disposed on the upper wall or side wall of the buffer tank 50, and a valve is mounted on the third inlet tube 51. 52. The intake pipe 56 is connected to the intake pipe 80 of the outer end of the ventilation duct 55 through the three-way 57, and the exhaust valve 58 is connected to the exhaust pipe 59 that communicates through the three-way 57. The valve 18 is provided. An inlet conduit 17 communicates with the inner chamber of the buffer tank 50 through the bottom wall of the buffer tank 50, and the buffer tank 50 and the upper wall or side wall of the first constant pressure tank 10 pass through the pressure equalizing tube 53 and the buffer tank 50 and the first constant The inner chamber of the pressure tank 10 is in communication, and the pressure equalizing tube 53 is provided with a valve 54.
上述的第二恒压罐20、第一恒压罐10和缓冲罐50的上方内壁上设置有一圈U型的挂钩或周向均布有挂钩103，塑料袋60的上端开口部镶嵌或挂设在挂钩103上，洁净(例如消毒灭菌后)的塑料袋60的底壁上设置有与塑料袋60的内腔连通的硬质且中空的插管61，插管61的外径与第二恒压罐20、第一恒压罐10或/和缓冲罐50底壁上的中空的连接管101的内径相配合，插管61的内径与外接插头70的外径72相配合，插管61的内径与外接插头70的外径之间设置有密封圈73，插管与外接插头通过内外径配合，辅以密封圈插接连接，所述的出液导管40、45连接在外接插头70上。The upper inner wall of the second constant pressure tank 20, the first constant pressure tank 10 and the buffer tank 50 is provided with a U-shaped hook or a circumferentially distributed hook 103. The upper end opening of the plastic bag 60 is inlaid or hung on the hook. 103, on the bottom wall of the clean (for example, after sterilization) plastic bag 60 is provided with a rigid and hollow cannula 61 communicating with the inner cavity of the plastic bag 60, the outer diameter of the cannula 61 and the second constant pressure The tank 20, the first constant pressure tank 10 or/and the inner diameter of the hollow connecting pipe 101 on the bottom wall of the buffer tank 50 are fitted, and the inner diameter of the cannula 61 is matched with the outer diameter 72 of the external plug 70, and the inner diameter of the cannula 61 A sealing ring 73 is disposed between the outer diameter of the external plug 70, and the outer plug is coupled to the external plug through the inner and outer diameters, and is connected by a sealing ring. The outlet conduits 40 and 45 are connected to the external plug 70.
上述的外接插头70与连接管101之间通过法兰盘102、71或螺纹连接部或快装接头连接。The external plug 70 and the connecting pipe 101 described above are connected by a flange 102, 71 or a screw connection or a quick connector.
上述的第一恒压罐10与第二恒压罐20上的出液导管40、45的外端部通过三通43连接后的三通43的第三通连接的导管42上连接有除病毒夹具或过滤器；或出液导管40的外端部上连接有除病毒夹具或过滤器。The first constant pressure tank 10 and the third end connection conduit 42 of the tee 43 connected to the outer end of the outlet conduits 40, 45 on the second constant pressure tank 20 through the tee 43 are connected with a virus removal. A jig or filter; or a virus removing jig or filter is attached to the outer end of the liquid outlet conduit 40.
上述的第一恒压罐10与第二恒压罐20上的进气管16、26共用一个压缩气体源81，压缩气体源81提供的压缩气体的压力可根据工艺需求调节设定，例如 气体压力为2bar。The first constant pressure tank 10 and the intake pipes 16, 26 on the second constant pressure tank 20 share a compressed gas source 81, and the pressure of the compressed gas supplied from the compressed gas source 81 can be adjusted according to process requirements, for example, The gas pressure is 2 bar.
上述的第一恒压罐10与缓冲罐50上的进气管16、80共用一个，压缩气体源81提供的压缩气体的压力可根据工艺需求调节设定，例如气体压力为2bar。The first constant pressure tank 10 described above shares one with the intake pipes 16, 80 on the buffer tank 50, and the pressure of the compressed gas supplied from the compressed gas source 81 can be adjusted according to the process demand, for example, the gas pressure is 2 bar.
上述的气动恒压的液体连续送料装置的连续送料方法是：具有所述的第一恒压罐10和第二恒压罐20的液体连续送料装置中：当第一恒压罐10常压进料时，第二恒压罐20通入一定压力的压缩气体连续供料，当第二恒压罐20常压进料时，第一恒压罐10通入一定压力的压缩气体连续供料，第一恒压罐10与第二恒压罐20交替地进料和送料，从而实现气动恒压的液体连续送料；或具有所述的第一恒压罐10和缓冲罐50的液体连续送料装置中：由缓冲罐50周期性地进料并周期性地为第一恒压罐10补充进料，由第一恒压罐10通入一定压力的压缩气体并连续供料，从而实现气动恒压的液体连续送料。The above continuous feeding method of the pneumatic constant pressure liquid continuous feeding device is: in the liquid continuous feeding device having the first constant pressure tank 10 and the second constant pressure tank 20: when the first constant pressure tank 10 is constantly pressurized During the feeding, the second constant pressure tank 20 is continuously fed with a compressed gas of a certain pressure. When the second constant pressure tank 20 is fed at a normal pressure, the first constant pressure tank 10 is continuously fed with a compressed gas of a certain pressure. The first constant pressure tank 10 and the second constant pressure tank 20 are alternately fed and fed to realize continuous feeding of the liquid of a constant constant pressure; or the liquid continuous feeding device having the first constant pressure tank 10 and the buffer tank 50 Medium: periodically feeding from the buffer tank 50 and periodically replenishing the first constant pressure tank 10, and the first constant pressure tank 10 is supplied with a compressed gas of a certain pressure and continuously supplied to achieve a pneumatic constant pressure. The liquid is continuously fed.
本发明的工作过程：The working process of the invention:
一、本发明结构之一的工作过程，参见图1及图3、图4：1. The working process of one of the structures of the present invention, see Figure 1 and Figure 3, Figure 4:
打开第一恒压罐10、第二恒压罐20的顶盖，将洁净的塑料袋60分别悬挂在第一恒压罐10、第二恒压罐20的挂钩103上并用环形压块104压紧，将塑料袋60插管61分别从第一恒压罐10、第二恒压罐20底部中空的连接管101内向下穿出，并与外接插头70的上部插接好，外接插头70的法兰盘71与连接管101上的法兰盘102通过连接，外接插头70的下部连接出液导管40、45并通过三通43连接出液导管42，出液导管42的外端连接过滤器，关闭第一恒压罐10、第二恒压罐20的顶盖，第一进液导管17、第二进液导管27通过三通29连接进液导管31，进液导管31的外端与储液袋30或储液罐的出液接头连接，关闭所有的阀门，通气导管26、16外接压缩气体源81，打开阀门18、13后，储液袋 30或储液罐内的液体靠高度差形成的压力自动流入第一恒压罐10后，待第一恒压罐10液面到达一定高度(高限)，关闭阀门18、13，依次打开阀门15及41，在压缩气体源81的压缩气体的压力为2bar的恒压情况下，第一恒压罐10内的液体稳定地通过出液导管40、42进入过滤器进行过滤；在第一恒压罐10工作的过程中，打开阀门28、23，使得储液袋30或储液罐内的液体靠高度差形成的压力自动流入第二恒压罐20后，待第二恒压罐20液面到达一定高度(高限)，关闭阀门28、23并打开阀门25加压待用，待第一恒压罐10液面到达一定高度(低限)，打开阀门44，关闭阀门41、15后第一恒压罐10停止供液，由第二恒压罐20接替供液，实现了不间断的连续供液及过滤，然后打开阀门13排空第一恒压罐10内的压力，再打开阀门18向使得储液袋30或储液罐内的液体靠高度差形成的压力自动流入第一恒压罐10，待第一恒压罐10液面到达一定高度(高限)，后关闭阀门18、13，打开阀门15加压备用，储液袋30或储液罐在其内的液体全部输出后可以在常压下更换新的储液袋30或储液罐，不影响连续供料；当然，如果对料液的洁净要求不高，或对第一恒压罐10及第二恒压罐20的内壁清洁要求不高的话，也可以不用塑料袋60及其配套的插管61等部件。The top cover of the first constant pressure tank 10 and the second constant pressure tank 20 is opened, and the clean plastic bags 60 are respectively hung on the hooks 103 of the first constant pressure tank 10 and the second constant pressure tank 20 and pressed by the annular pressure block 104. Tightly, the plastic bag 60 cannula 61 is respectively passed downward from the hollow connecting tube 101 at the bottom of the first constant pressure tank 10 and the second constant pressure tank 20, and is inserted into the upper portion of the external plug 70, and the external plug 70 is externally connected. The flange 71 is connected to the flange 102 on the connecting pipe 101, and the lower portion of the external plug 70 is connected to the liquid outlet conduits 40, 45 and connected to the liquid outlet conduit 42 through the tee 43. The outer end of the liquid outlet conduit 42 is connected to the filter. The top cover of the first constant pressure tank 10 and the second constant pressure tank 20 is closed, and the first inlet conduit 17 and the second inlet conduit 27 are connected to the inlet conduit 31 through the tee 29, and the outer end of the inlet conduit 31 is The liquid supply bag 30 or the liquid outlet of the liquid storage tank is connected to close all the valves, the ventilation pipes 26 and 16 are externally connected to the compressed gas source 81, and after opening the valves 18 and 13, the liquid storage bag 30. After the pressure formed by the height difference of the liquid in the liquid storage tank automatically flows into the first constant pressure tank 10, the liquid level of the first constant pressure tank 10 reaches a certain height (high limit), the valves 18 and 13 are closed, and the valves are sequentially opened. 15 and 41, in the case where the pressure of the compressed gas of the compressed gas source 81 is 2 bar, the liquid in the first constant pressure tank 10 is stably filtered through the liquid outlet conduits 40 and 42 into the filter; During the operation of the pressure tank 10, the valves 28, 23 are opened, so that the pressure formed by the liquid in the liquid storage bag 30 or the liquid storage tank automatically flows into the second constant pressure tank 20, and the second constant pressure tank 20 is liquid. The surface reaches a certain height (high limit), the valves 28, 23 are closed and the valve 25 is opened for use, and the liquid level of the first constant pressure tank 10 reaches a certain height (low limit), the valve 44 is opened, and the valves 41, 15 are closed. The first constant pressure tank 10 stops supplying liquid, and the second constant pressure tank 20 takes over the liquid supply, realizes continuous continuous liquid supply and filtration, and then opens the valve 13 to evacuate the pressure in the first constant pressure tank 10, and then opens The valve 18 automatically flows into the first pressure that causes the liquid in the liquid storage bag 30 or the liquid storage tank to be separated by the height difference. The constant pressure tank 10, after the liquid level of the first constant pressure tank 10 reaches a certain height (high limit), then closes the valves 18, 13, opens the valve 15 for pressurization, and the liquid in the liquid storage bag 30 or the liquid storage tank is all After the output, the new liquid storage bag 30 or the liquid storage tank can be replaced under normal pressure without affecting the continuous feeding; of course, if the cleaning requirement of the liquid is not high, or the first constant pressure tank 10 and the second constant pressure If the cleaning of the inner wall of the can 20 is not high, the components such as the plastic bag 60 and its associated cannula 61 may not be used.
二、本发明结构之二的工作过程，参见图2及图3、图4：Second, the working process of the second structure of the present invention, see Figure 2 and Figure 3, Figure 4:
打开第一恒压罐10、缓冲罐50的顶盖，将洁净的塑料袋60分别悬挂在第一恒压罐10、缓冲罐50的挂钩103上并用环形压块104压紧，将塑料袋60插管61分别从第一恒压罐10、缓冲罐50底部中空的连接管101内向下穿出，并与外接插头70的上部插接好，外接插头70的法兰盘71与连接管101上的法兰盘102通过连接，外接插头70的下部连接出液导管40，出液导管40的外端连接过滤器，关闭第一恒压罐10、缓冲罐50的顶盖，第一 恒压罐10、缓冲罐50的进气导管80、16通过三通连接外接压缩气体源81，进液导管31的外端与储液袋30或储液罐的出液接头连接，关闭所有的阀门，打开阀门52、18及13后，储液袋30或储液罐内的液体靠高度差形成的压力先自动流入缓冲罐50后再流入第一恒压罐10，待第一恒压罐10液面到达一定高度(高限)，关闭阀门52、18及13，依次打开阀门15及41，在压缩气体源81的压缩气体的压力为2bar的恒压情况下，第一恒压罐10内的液体稳定地通过出液导管41进入过滤器，进行过滤；在第一恒压罐10工作的过程中，打开阀门52、58，使得储液袋30或储液罐内的液体靠高度差形成的压力自动流入缓冲罐50，待缓冲罐50液面到达一定高度(高限)，关闭阀门52、58，打开阀门56加压，待缓冲罐50压力稳定，关闭阀门56，打开阀门54，消除缓冲罐50与第一恒压罐10内之间可能存在的微小压力差；待第一恒压罐10内液面到达一定高度(低限)，打开阀门18，使得缓冲罐50内的液体靠高度差形成的压力自动流入第一恒压罐10内，补液完成后关闭阀门18、54，打开阀门58，排空缓冲罐50内的气压，打开阀门52，进入下一个进料循环，依此循环操作，实现了不间断的连续供液及过滤；储液袋30或储液罐在其内的液体全部输出后可以在常压下更换新的储液袋30或储液罐，不影响连续供料；当然，如果对料液的洁净要求不高，或对第一恒压罐10及第二恒压罐20的内壁清洁要求不高的话，也可以不用塑料袋60及其配套的插管61等部件。The top cover of the first constant pressure tank 10 and the buffer tank 50 is opened, and the clean plastic bags 60 are respectively hung on the hooks 103 of the first constant pressure tank 10 and the buffer tank 50, and are pressed by the annular pressing block 104 to press the plastic bag 60. The cannula 61 is respectively passed downward from the hollow connecting tube 101 at the bottom of the first constant pressure tank 10 and the buffer tank 50, and is inserted into the upper portion of the external plug 70, and the flange 71 of the external plug 70 and the connecting tube 101 are connected. The flange 102 is connected, the lower portion of the external plug 70 is connected to the liquid outlet conduit 40, and the outer end of the liquid outlet conduit 40 is connected to the filter to close the top cover of the first constant pressure tank 10 and the buffer tank 50, first The inlet tanks 80 and 16 of the constant pressure tank 10 and the buffer tank 50 are connected to the external compressed gas source 81 through a three-way connection, and the outer end of the inlet conduit 31 is connected with the liquid supply bag 30 or the liquid outlet of the liquid storage tank, and all of them are closed. After the valves 52, 18 and 13 are opened, the pressure formed by the height difference between the liquid in the liquid storage bag 30 or the liquid storage tank first flows into the buffer tank 50 and then flows into the first constant pressure tank 10, and waits for the first constant pressure tank. The liquid level reaches a certain height (high limit), the valves 52, 18 and 13 are closed, and the valves 15 and 41 are sequentially opened. The first constant pressure tank 10 is under the constant pressure of the compressed gas source of the compressed gas source 81 of 2 bar. The liquid inside is stably passed into the filter through the outlet conduit 41 for filtration; during the operation of the first constant pressure tank 10, the valves 52, 58 are opened to make the liquid in the liquid storage bag 30 or the liquid storage tank high in height difference. The formed pressure automatically flows into the buffer tank 50, and the liquid level of the buffer tank 50 reaches a certain height (high limit), the valves 52, 58 are closed, the valve 56 is opened to pressurize, the pressure of the buffer tank 50 is stabilized, the valve 56 is closed, and the valve 54 is opened. Eliminating the slight pressure that may exist between the buffer tank 50 and the first constant pressure tank 10 When the liquid level in the first constant pressure tank 10 reaches a certain height (low limit), the valve 18 is opened, so that the pressure formed by the height difference of the liquid in the buffer tank 50 automatically flows into the first constant pressure tank 10, and is closed after the liquid replacement is completed. The valves 18, 54 open the valve 58, evacuate the air pressure in the buffer tank 50, open the valve 52, and enter the next feeding cycle, thereby performing an uninterrupted continuous liquid supply and filtration according to the cycle; the liquid storage bag 30 or After the liquid in the liquid storage tank is completely output, the new liquid storage bag 30 or the liquid storage tank can be replaced under normal pressure without affecting the continuous feeding; of course, if the cleaning requirement of the liquid liquid is not high, or the first If the inner wall cleaning requirements of the constant pressure tank 10 and the second constant pressure tank 20 are not high, the plastic bag 60 and its associated cannula 61 and the like may not be used.
根据本发明结构之一的工作过程，制作了可自动运行的小型样机(参见图5、图6)，实现了稳定压力下的自动化连续送料，验证了本发明的实用性。使用压力传感器201实时监控第一恒压罐10的压力，使用压力传感器211实时监控第二恒压罐20的压力，使用压力传感器221实时监控过 滤器222的进液压力；使用上液位传感器202和下液位传感器203监控第一恒压罐10的液位上限和下限，使用上液位传感器212和下液位传感器213监控第二恒压罐20的液位上限和下限。自动化控制器由以下部分组成：使用OMRON小型PLC 230(含模拟量扩展模块)根据接收的第一恒压罐10、第二恒压罐20的压力和液位信号以及过滤器222的压力信号，自动发送动作指令(通过继电器组240～247)至电磁阀15(控制第一恒压罐10的进气)、电磁阀13(控制第一恒压罐10的排气)、电磁阀25(控制第二恒压罐20的进气)、电磁阀23(控制第二恒压罐20的排气)、电磁阀231(用于控制气动隔膜阀18的开闭)、电磁阀232(用于控制气动隔膜阀41的开闭)、电磁阀233(用于控制气动隔膜阀28的开闭)、电磁阀234(用于控制气动隔膜阀44的开闭)；使用威纶通触摸屏235显示与控制工作状态；使用24V开关电源236为控制系统供电。According to the working process of one of the structures of the present invention, a small prototype which can be automatically operated (see Figs. 5 and 6) is produced, and automatic continuous feeding under stable pressure is realized, and the practicability of the present invention is verified. The pressure of the first constant pressure tank 10 is monitored in real time using the pressure sensor 201, and the pressure of the second constant pressure tank 20 is monitored in real time using the pressure sensor 211, and is monitored in real time using the pressure sensor 221. The inlet pressure of the filter 222; the upper limit and the lower limit of the liquid level of the first constant pressure tank 10 are monitored using the upper level sensor 202 and the lower level sensor 203, and the second constant pressure is monitored using the upper level sensor 212 and the lower level sensor 213 The upper and lower limits of the tank 20 are. The automation controller is composed of the following components: using the OMRON small PLC 230 (including the analog expansion module) according to the received pressure and level signals of the first constant pressure tank 10, the second constant pressure tank 20, and the pressure signal of the filter 222, Automatically send action commands (via relay groups 240-247) to solenoid valve 15 (control intake of first constant pressure tank 10), solenoid valve 13 (control exhaust of first constant pressure tank 10), solenoid valve 25 (control Intake of the second constant pressure tank 20, solenoid valve 23 (control of exhaust of the second constant pressure tank 20), solenoid valve 231 (for controlling opening and closing of the pneumatic diaphragm valve 18), and solenoid valve 232 (for control) Opening and closing of the pneumatic diaphragm valve 41, solenoid valve 233 (for controlling opening and closing of the pneumatic diaphragm valve 28), solenoid valve 234 (for controlling opening and closing of the pneumatic diaphragm valve 44); display and control using the Weiluntong touch screen 235 Operating state; power is supplied to the control system using a 24V switching power supply 236.
按照图5、图6安装过滤系统、接好压缩气源(1.2bar压缩空气用于驱动液体，5bar压缩空气用于驱动气动隔膜阀)、系统上电，通过触摸屏235控制运行开始。运行开始后，电磁阀13打开，待压力传感器201反馈第一恒压罐10内的压力与外界大气压相等后，PLC 230传递信号开启电磁阀231，由电磁阀231控制的压缩空气驱动开启气动隔膜阀18，料液从储液袋30依靠重力进入第一恒压罐10；当第一恒压罐10内料液液位升高至接触上液位传感器202，上液位传感器202反馈信号至PLC 230，PLC 230传递信号关闭电磁阀231(即关闭气动隔膜阀18)，PLC 230再传递信号关闭电磁阀13，传递信号开启电磁阀15，传递信号开启电磁阀232(即开启气动隔膜阀41)，压缩空气短时间内进入第一恒压罐10并平衡，第一恒压罐10的料液开始过滤；相隔5秒钟后，PLC 230传递信号开启电磁阀23，待压力传感器211显示控制第二恒压罐20内的压力与外界大气压相等后，PLC 230传递信号开启电磁阀233(即开启气动隔膜阀28)，料液从储液袋30依靠重力进入第二恒压罐20；当第二恒压罐20内料液液位升高 至接触上液位传感器212，上液位传感器212反馈信号至PLC 230，PLC 230传递信号关闭电磁阀233(即关闭气动隔膜阀28)，PLC 230再传递信号关闭电磁阀23，传递信号开启电磁阀25，压缩空气短时间内进入第二恒压罐20并平衡至与第一恒压罐10内气压相等，第二恒压罐20等待过滤；当第一恒压罐10中的料液液位随过滤的进行降低至离开下液位传感器203，下液位传感器203反馈信号至PLC 230，PLC 230传递信号开启电磁阀234(即开启气动隔膜阀44)，2秒钟后PLC 230传递信号关闭电磁阀232(即关闭气动隔膜阀41)，2秒钟后PLC 230传递信号开启电磁阀13，第一恒压罐10泄压，压力传感器201反馈第一恒压罐10内的压力与外界大气压相等后，PLC 230传递信号开启电磁阀231(即开启气动隔膜阀18)，料液从储液袋30依靠重力进入第一恒压罐10；至此，本系统过滤操作完成一个循环。当储液袋30中的料液处理完毕，或从触摸屏235上人为终止之前，该过滤操作过程可以自动连续进行，并保持过滤器222的进口处压力相对恒定。在过滤操作过程中，压力传感器201、211、221的压力信号数据可通过触摸屏或连接电脑进行实时显示与保存。Install the filter system according to Figure 5 and Figure 6, connect the compressed air source (1.2 bar compressed air for driving the liquid, 5 bar compressed air for driving the pneumatic diaphragm valve), power on the system, and control the operation through the touch screen 235. After the start of the operation, the solenoid valve 13 is opened. After the pressure sensor 201 feeds back the pressure in the first constant pressure tank 10 to be equal to the external atmospheric pressure, the PLC 230 transmits a signal to open the solenoid valve 231, and the compressed air controlled by the solenoid valve 231 drives the pneumatic diaphragm to open. The valve 18, the material liquid enters the first constant pressure tank 10 from the liquid storage bag 30 by gravity; when the liquid level in the first constant pressure tank 10 rises to contact the liquid level sensor 202, the upper liquid level sensor 202 feeds back the signal to PLC 230, PLC 230 transmits a signal to close the solenoid valve 231 (ie, closes the pneumatic diaphragm valve 18), the PLC 230 transmits a signal to close the solenoid valve 13, transmits a signal to open the solenoid valve 15, and transmits a signal to open the solenoid valve 232 (ie, opens the pneumatic diaphragm valve 41) The compressed air enters the first constant pressure tank 10 and is balanced for a short time, and the liquid of the first constant pressure tank 10 starts to filter; after 5 seconds, the PLC 230 transmits a signal to open the electromagnetic valve 23, and the pressure sensor 211 displays control. After the pressure in the second constant pressure tank 20 is equal to the external atmospheric pressure, the PLC 230 transmits a signal to open the electromagnetic valve 233 (ie, opens the pneumatic diaphragm valve 28), and the liquid liquid enters the second constant pressure tank 20 from the liquid storage bag 30 by gravity; Constant voltage within two liquid feed tank 20 level rises To contact the upper level sensor 212, the upper level sensor 212 feeds back a signal to the PLC 230, the PLC 230 transmits a signal to close the solenoid valve 233 (ie, closes the pneumatic diaphragm valve 28), and the PLC 230 transmits a signal to close the solenoid valve 23, transmitting a signal to turn on the electromagnetic The valve 25, the compressed air enters the second constant pressure tank 20 in a short time and is balanced to be equal to the air pressure in the first constant pressure tank 10, and the second constant pressure tank 20 waits for filtration; when the liquid liquid in the first constant pressure tank 10 The position is lowered to the lower level sensor 203 as the filter progresses, the lower level sensor 203 feeds back the signal to the PLC 230, and the PLC 230 transmits a signal to open the solenoid valve 234 (ie, opens the pneumatic diaphragm valve 44), and after 2 seconds, the PLC 230 transmits a signal. The solenoid valve 232 is closed (ie, the pneumatic diaphragm valve 41 is closed), and after 2 seconds, the PLC 230 transmits a signal to open the solenoid valve 13, the first constant pressure tank 10 is released from pressure, and the pressure sensor 201 feeds back the pressure in the first constant pressure tank 10 and the outside. After the atmospheric pressure is equal, the PLC 230 transmits a signal to open the solenoid valve 231 (i.e., opens the pneumatic diaphragm valve 18), and the liquid enters the first constant pressure tank 10 from the liquid storage bag 30 by gravity; thus, the filtration operation of the system completes one cycle. The filtration operation can be automatically and continuously performed while the feed in the reservoir 30 is processed, or before artificially terminating from the touch screen 235, and the pressure at the inlet of the filter 222 is maintained relatively constant. During the filtering operation, the pressure signal data of the pressure sensors 201, 211, 221 can be displayed and saved in real time through a touch screen or connected to a computer.
典型的工作过程中，压力传感器201、211、221的压力信号见图7。图7中，①阶段为第一恒压罐10正在过滤送料中，第二恒压罐20已加压待滤；②阶段为第一恒压罐10中料液低于液位下限，停止送料并排气泄压，第二恒压罐20接替送料；③阶段为第一恒压罐10常压进料，第二恒压罐20正在过滤送料中；④阶段为第一恒压罐10进料完毕，加压，第二恒压罐20正在过滤送料中；⑤阶段为第一恒压罐10加压待滤，第二恒压罐20正在过滤送料中；⑥阶段为第二恒压罐20中料液低于液位下限，停止送料并排气泄压，第一恒压罐10接替送料；⑦阶段为第二恒压罐20常压进料，第一恒压罐10正在过滤送料中；⑧阶段为第二恒压罐20进料完毕，加压，第一恒压罐10正在过滤送料中；⑨阶段为第二恒压罐20加压待滤，第一恒压罐10正在过滤送料中；⑩阶段为第一恒压罐10中料液低于液位 下限，停止送料并排气泄压，第二恒压罐20接替送料；
Figure PCTCN2015095752-appb-000003
为第二恒压罐20正在过滤送料中，第一恒压罐10不再继续进料。The pressure signals of the pressure sensors 201, 211, 221 are shown in Figure 7 during typical operation. In Fig. 7, the first stage is that the first constant pressure tank 10 is being filtered, the second constant pressure tank 20 is pressurized to be filtered; the second stage is that the first constant pressure tank 10 is lower than the liquid level lower limit, and the feeding is stopped. And the exhaust pressure is released, the second constant pressure tank 20 takes over the feeding; the third stage is the first constant pressure tank 10 is pressurized, the second constant pressure tank 20 is filtering the feeding; the fourth stage is the first constant pressure tank 10 After the material is finished, pressurized, the second constant pressure tank 20 is filtering the feed; the fifth stage is for the first constant pressure tank 10 to be filtered, the second constant pressure tank 20 is filtering the feed; the sixth stage is the second constant pressure tank 20 medium liquid is lower than the lower limit of liquid level, stop feeding and exhaust pressure release, first constant pressure tank 10 takes over feeding; 7 stage is second constant pressure tank 20 normal pressure feeding, first constant pressure tank 10 is filtering feeding In the 8th stage, the second constant pressure tank 20 is fed, pressurized, the first constant pressure tank 10 is filtering the feed; the 9th stage pressurizes the second constant pressure tank 20 to be filtered, and the first constant pressure tank 10 is being In the filtration feeding; the 10th stage is that the first constant pressure tank 10 is lower than the liquid level lower limit, the feeding is stopped and the exhaust pressure is released, and the second constant pressure tank 20 takes over the feeding;
Figure PCTCN2015095752-appb-000003
In the case where the second constant pressure tank 20 is being filtered, the first constant pressure tank 10 is no longer fed.
类似地，本发明中的两点式液位传感器可改用超声波液位传感器或称重传感器来对第一恒压罐10和第二恒压罐20内的液体体积进行连续精确地监控。Similarly, the two-point liquid level sensor of the present invention can use an ultrasonic level sensor or a load cell to continuously and accurately monitor the liquid volume in the first constant pressure tank 10 and the second constant pressure tank 20.
类似地，本发明中进料方式除依靠重力进料外，可改用抽真空进料与泵进料。Similarly, in the present invention, the feed mode can be switched to vacuum feed and pump feed in addition to gravity feed.
上述实施例仅为本发明的较佳实施例，并非依此限制本发明的保护范围，故：凡依本发明的结构、形状、原理所做的等效变化，均应涵盖于本发明的保护范围之内。 The above embodiments are merely preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. Therefore, equivalent changes made to the structures, shapes, and principles of the present invention should be covered by the present invention. Within the scope.

Claims (7)

  1. 气动恒压的液体连续送料装置，其特征在于：包括第一恒压罐，第一恒压罐的上壁或侧壁上设置有与第一恒压罐内腔连通的通气导管，通气导管的外端部通过三通连通的进气管上安装有进气阀、通过三通连通的排空管上安装有排空阀，第一恒压罐的罐壁的底壁上设置有与第一恒压罐内腔连通的出液导管、上壁或侧壁上设置有与第一恒压罐内腔连通的第一进液导管，第一进液导管和出液导管上均设置有阀门；其中的第一进液导管上有下述两种外接部件之一：A pneumatic constant pressure liquid continuous feeding device, comprising: a first constant pressure tank, wherein an upper wall or a side wall of the first constant pressure tank is provided with a ventilation duct communicating with the inner chamber of the first constant pressure tank, the ventilation duct An air intake valve is connected to the intake pipe through the three-way communication portion, and an air discharge valve is installed on the air discharge pipe connected through the three-way. The bottom wall of the tank wall of the first constant pressure tank is provided with the first constant a first inlet conduit communicating with the inner chamber of the first constant pressure tank is disposed on the outlet conduit, the upper wall or the side wall of the pressure vessel inner cavity, and the first inlet conduit and the outlet conduit are respectively provided with a valve; The first inlet conduit has one of the following two external components:
    第一进液导管上的第一种外接部件的结构是：第二恒压罐的上壁或侧壁上设置有与第二恒压罐内腔连通的通气导管，通气导管的外端部通过三通连通的进气管上安装有进气阀、通过三通连通的排空管上安装有排空阀，第二恒压罐的罐壁的底壁上设置有与第二恒压罐内腔连通的出液导管、上壁或侧壁上设置有与第二恒压罐内腔连通的第二进液导管，第二进液导管和出液导管上均设置有阀门，第一恒压罐与第二恒压罐上的第一、第二进液导管的外端部通过三通连接，第一恒压罐与第二恒压罐上的出液导管的外端部通过三通连接；The first external connecting member on the first inlet conduit is configured such that a ventilation duct communicating with the inner chamber of the second constant pressure tank is disposed on the upper wall or the side wall of the second constant pressure tank, and the outer end portion of the ventilation conduit is passed An intake valve is installed on the intake pipe connected to the three-way, and an emptying valve is connected to the exhaust pipe through the three-way communication, and the bottom wall of the tank wall of the second constant pressure tank is provided with the second constant pressure tank inner cavity a second liquid inlet conduit communicating with the inner chamber of the second constant pressure tank is disposed on the outlet conduit, the upper wall or the side wall, and the second inlet conduit and the outlet conduit are respectively provided with a valve, the first constant pressure tank The outer end portions of the first and second liquid inlet conduits on the second constant pressure tank are connected by a three-way connection, and the outer ends of the first constant pressure tank and the second constant pressure tank are connected by a three-way joint;
    第一进液导管上的第二种外接部件的结构是：缓冲罐的上壁或侧壁上设置有第三进液管和通气导管，第三进液管上安装有阀门，通气导管的外端部通过三通连通的进气管上安装有进气阀、通过三通连通的排空管上安装有排空阀，设置有阀门的第一进液导管通过缓冲罐的底壁与缓冲罐的内腔连通，缓冲罐和第一恒压罐的上壁或侧壁通过均压管与缓冲罐和第一恒压罐的内腔连通，均压管上设置有阀门。The second external component on the first inlet conduit has a structure in which a third inlet pipe and a ventilation conduit are disposed on the upper wall or the side wall of the buffer tank, and a valve is installed on the third inlet pipe, and the ventilation conduit is externally An intake valve is installed on the intake pipe through which the end is connected through the three-way, and an emptying pipe is connected to the exhaust pipe through the three-way communication, and the first inlet conduit provided with the valve passes through the bottom wall of the buffer tank and the buffer tank The inner chamber is connected, and the buffer tank and the upper wall or the side wall of the first constant pressure tank are connected to the buffer tank and the inner chamber of the first constant pressure tank through the pressure equalizing tube, and the equalizing tube is provided with a valve.
  2. 根据权利要求1所述的气动恒压的液体连续送料装置，其特征在于：所述的第一恒压罐、第二恒压罐和缓冲罐的上方内壁上均设置有一圈挂钩或周向 均布有挂钩，洁净的塑料袋的上端开口部镶嵌或挂设在挂钩上，塑料袋的底壁上设置有与塑料袋的内腔连通的硬质且中空的插管，插管的外径与第二恒压罐、第一恒压罐或/和缓冲罐底壁上的中空的连接管的内径相配合，插管的内径与外接插头的外径相配合，插管的内径与外接插头的外径之间设置有密封圈，插管与外接插头通过内外径配合，辅以密封圈连接，所述的出液导管连接在外接插头上。The pneumatic constant pressure liquid continuous feeding device according to claim 1, wherein a hook or a circumferential direction is arranged on the upper inner wall of the first constant pressure tank, the second constant pressure tank and the buffer tank. The hooks are evenly distributed, and the upper end of the clean plastic bag is inlaid or hung on the hook, and the bottom wall of the plastic bag is provided with a rigid and hollow cannula communicating with the inner cavity of the plastic bag, and the outer diameter of the cannula Cooperating with the inner diameter of the second constant pressure tank, the first constant pressure tank or/and the hollow connecting pipe on the bottom wall of the buffer tank, the inner diameter of the cannula is matched with the outer diameter of the external plug, the inner diameter of the cannula and the external plug A sealing ring is disposed between the outer diameters, and the insertion tube and the external plug are matched by the inner and outer diameters, and are connected by a sealing ring, and the liquid outlet conduit is connected to the external plug.
  3. 根据权利要求2所述的气动恒压的液体连续送料装置，其特征在于：所述的外接插头与连接管之间通过法兰盘或螺纹连接部或快装接头连接。The pneumatic constant pressure liquid continuous feeding device according to claim 2, wherein the external plug and the connecting pipe are connected by a flange or a screw connection or a quick connector.
  4. 根据权利要求1-3任一项所述的气动恒压的液体连续送料装置，其特征在于：所述的第一恒压罐与第二恒压罐上的出液导管的外端部通过三通连接后的三通的第三通连接的导管上连接有过滤器；或出液导管的外端部上连接有过滤器。The pneumatic constant pressure liquid continuous feeding device according to any one of claims 1 to 3, wherein the outer end portions of the first constant pressure tank and the second constant pressure tank are passed through three A filter is connected to the third-connected conduit of the connected tee; or a filter is connected to the outer end of the outlet conduit.
  5. 根据权利要求1-3任一项所述的气动恒压的液体连续送料装置，其特征在于：所述的第一恒压罐与第二恒压罐上的进气管共用一个压缩气体源，压缩气体源提供的压缩气体的压力根据工艺需求可以调节设定。The pneumatic constant pressure liquid continuous feeding device according to any one of claims 1 to 3, wherein the first constant pressure tank and the intake pipe on the second constant pressure tank share a compressed gas source and are compressed. The pressure of the compressed gas supplied by the gas source can be adjusted according to the process requirements.
  6. 根据权利要求1-3任一项所述的气动恒压的液体连续送料装置，其特征在于：所述的第一恒压罐与缓冲罐上的进气管共用一个压缩气源，压缩气体源提供的压缩气体的压力根据工艺需求可以调节设定。The pneumatic constant pressure liquid continuous feeding device according to any one of claims 1 to 3, wherein the first constant pressure tank shares a compressed air source with the intake pipe on the buffer tank, and the compressed gas source provides The pressure of the compressed gas can be adjusted according to the process requirements.
  7. 根据权利要求1-3任一项所述的气动恒压的液体连续送料装置的连续送料方法，其特征在于：具有所述的第一恒压罐和第二恒压罐的液体连续送料装置中：当第一恒压罐常压进料时，第二恒压罐通入一定压力的压缩气体连续供料，当第二恒压罐常压进料时，第一恒压罐通入一定压力的压缩气体连续供 料，第一恒压罐与第二恒压罐交替地进料和送料，从而实现气动恒压的液体连续送料；或具有所述的第一恒压罐和缓冲罐的液体连续送料装置中：由缓冲罐周期性地进料并周期性地为第一恒压罐补充进料，由第一恒压罐通入一定压力的压缩气体并连续供料，从而实现气动恒压的液体连续送料。 A continuous feeding method of a pneumatic constant pressure liquid continuous feeding device according to any one of claims 1 to 3, characterized in that, in the liquid continuous feeding device having the first constant pressure tank and the second constant pressure tank When the first constant pressure tank is fed at normal pressure, the second constant pressure tank is continuously supplied with a compressed gas of a certain pressure, and when the second constant pressure tank is fed at a normal pressure, the first constant pressure tank is fed with a certain pressure. Compressed gas continuously supplied The first constant pressure tank and the second constant pressure tank are alternately fed and fed to realize continuous feeding of the pneumatic constant pressure liquid; or the liquid continuous feeding device having the first constant pressure tank and the buffer tank: The buffer tank is periodically fed and periodically replenishes the first constant pressure tank, and the first constant pressure tank is supplied with a compressed gas of a certain pressure and continuously supplied, thereby achieving continuous feeding of the pneumatic constant pressure liquid.
PCT/CN2015/095752 2014-12-20 2015-11-27 Pneumatic constant pressure continuous liquid feeding device and method WO2016095685A1 (en)

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