WO2015160842A8 - Methods and formulations of capsaicinoids and capsinoids - Google Patents

Methods and formulations of capsaicinoids and capsinoids Download PDF

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Publication number
WO2015160842A8
WO2015160842A8 PCT/US2015/025810 US2015025810W WO2015160842A8 WO 2015160842 A8 WO2015160842 A8 WO 2015160842A8 US 2015025810 W US2015025810 W US 2015025810W WO 2015160842 A8 WO2015160842 A8 WO 2015160842A8
Authority
WO
WIPO (PCT)
Prior art keywords
capsinoids
capsaicinoids
methods
formulations
compositions
Prior art date
Application number
PCT/US2015/025810
Other languages
French (fr)
Other versions
WO2015160842A1 (en
Inventor
Christoph Westphal
Jennifer CERMAK
Roderic O. COLE
Glenn F. Short, Iii
Robert Perni
Sridevi PONDURU
Original Assignee
Flex Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flex Pharma, Inc. filed Critical Flex Pharma, Inc.
Publication of WO2015160842A1 publication Critical patent/WO2015160842A1/en
Publication of WO2015160842A8 publication Critical patent/WO2015160842A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/262—Cellulose; Derivatives thereof, e.g. ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to compositions of capsaicinoids, capsinoids, or related analogs or combinations thereof, and methods of preparation, formulation, and the medical use of these compositions. In one aspect, the present invention features a composition formulated for oral administration, said composition comprising an effective amount of a capsaicinoid, capsinoid, or related analog or combination thereof.
PCT/US2015/025810 2014-04-14 2015-04-14 Methods and formulatiions of capsaicinoids and capsinoids WO2015160842A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461979405P 2014-04-14 2014-04-14
US61/979,405 2014-04-14
US201462073129P 2014-10-31 2014-10-31
US201462073258P 2014-10-31 2014-10-31
US62/073,258 2014-10-31
US62/073,129 2014-10-31

Publications (2)

Publication Number Publication Date
WO2015160842A1 WO2015160842A1 (en) 2015-10-22
WO2015160842A8 true WO2015160842A8 (en) 2016-03-17

Family

ID=54324507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/025810 WO2015160842A1 (en) 2014-04-14 2015-04-14 Methods and formulatiions of capsaicinoids and capsinoids

Country Status (1)

Country Link
WO (1) WO2015160842A1 (en)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
ES2759360T3 (en) 2015-10-09 2020-05-08 Axichem Ab Feed for poultry, and in particular feed for poultry, comprising synthetic capsaicinoid derivatives and feed of this type for prophylactic use or treatment of salmonella infection
KR20180101445A (en) * 2016-01-07 2018-09-12 코나겐 인크. Method for producing capcinoid by biosynthesis process
CA3017367A1 (en) * 2016-03-15 2017-09-21 Vitality Biopharma, Inc. Methods and compositions for the treatment of demyelinating disorders
WO2017160156A1 (en) * 2016-03-18 2017-09-21 Axichem Ab Synthetic capasaicin analogs as trpv1 agonists
BR112019000895A2 (en) 2016-07-19 2019-04-30 Conagen Inc. method for microbial production of specific natural capsaicinoids
EP3534961A4 (en) * 2016-11-02 2020-05-27 Centrexion Therapeutics Corporation Stable aqueous capsaicin injectable formulations and medical uses thereof
CA3043605A1 (en) * 2016-11-14 2018-05-17 Farm To Farma, Inc. Cannabinoid formulations and method of making the same
US11253493B2 (en) 2017-01-23 2022-02-22 Cliff-Cartwright Corporation Compositions and methods affecting exercise performance
JP2020506207A (en) * 2017-02-09 2020-02-27 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ Compositions and methods for the treatment of peripheral artery disease
EP3401307A1 (en) * 2017-05-11 2018-11-14 Antalgenics, S.L. Trpv1 modulator compounds
US11471429B2 (en) * 2017-10-20 2022-10-18 Axichem Ab Synthetic capsaicin analogues as bioenhancers
US11872231B2 (en) 2019-12-09 2024-01-16 Nicoventures Trading Limited Moist oral product comprising an active ingredient
US11793230B2 (en) 2019-12-09 2023-10-24 Nicoventures Trading Limited Oral products with improved binding of active ingredients
US11969502B2 (en) 2019-12-09 2024-04-30 Nicoventures Trading Limited Oral products
US11883527B2 (en) * 2019-12-09 2024-01-30 Nicoventures Trading Limited Oral composition and method of manufacture
US11826462B2 (en) 2019-12-09 2023-11-28 Nicoventures Trading Limited Oral product with sustained flavor release
CN115768270A (en) * 2020-07-01 2023-03-07 比利时胶囊公司 Dietary compositions and methods
CN112194592A (en) * 2020-11-11 2021-01-08 刘晓珍 Capsaicin salt and preparation method thereof
NO346587B1 (en) * 2021-06-02 2022-10-17 Axichem Ab Capsaicin derivatives in the treatment of idiopathic pulmonary fibrosis
CN115636767A (en) * 2021-07-20 2023-01-24 中国石油天然气股份有限公司 Biosurfactant for oil displacement and fracturing and preparation method thereof
CN115282134B (en) * 2022-07-20 2023-06-23 天津中医药大学 Application of capsaicin in preparation of medicine for treating fragile X syndrome
WO2024079518A1 (en) * 2022-10-14 2024-04-18 Nutriventia Limited Modified release formulation comprising capsaicinoids and a process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE285769T1 (en) * 1998-12-04 2005-01-15 Neurosearch As USE OF ISATINE DERIVATIVES AS ION CHANNEL ACTIVATION AGENTS
AU2005272802B2 (en) * 2004-08-11 2009-07-02 Intercontinental Great Brands Llc Sensate compositions and delivery systems therefor
EP1933813A4 (en) * 2005-10-11 2013-02-27 Univ Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
EP2629610B1 (en) * 2010-07-27 2017-09-06 Flex Pharma, Inc. Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
US9211274B2 (en) * 2012-02-01 2015-12-15 Warsaw Orthopedic, Inc. TRPV1 compounds in a biodegradable polymer carrier

Also Published As

Publication number Publication date
WO2015160842A1 (en) 2015-10-22

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