WO2014162439A1

WO2014162439A1 - Syringe

Info

Publication number: WO2014162439A1
Application number: PCT/JP2013/059911
Authority: WO
Inventors: 亜莉紗山下
Original assignee: テルモ株式会社
Priority date: 2013-04-01
Filing date: 2013-04-01
Publication date: 2014-10-09

Abstract

Provided is a syringe which does not have a plunger, is small and has excellent portability, and is capable of discharging a drug solution with simple operation. The syringe (10) comprises a tube (30) that is provided with a nozzle (31) on a distal end and an opening (34) on a base end, a gasket (42) that is inserted into the tube (30) and slides by being pressed, and a drug solution (41) that is contained inside the tube (30) between the nozzle (31) and the gasket (42) and is discharged from the nozzle (31) by the sliding of the gasket (42). The syringe (10) further comprises a tube inner magnet (43) that is inserted inside the tube (30) and an opposing magnet (46) that is fixed to the tube (30) or surrounds the tube (30) and produces bias with a magnetic repulsive force that is generated by causing the opposing magnet (46) and the tube inner magnet (43) to oppose each other by like poles to cause sliding of the gasket (42) toward the distal end of the tube (30). At least one of the tube inner magnet (43) and the opposing magnet (46) is locked by the tube (30), and pressing is started by loading up bias until the lock is released or by producing bias after the lock is released.

Description

Syringe

The present invention relates to a syringe in which a gasket slides by magnetic repulsion without having a plunger.

The syringe is used when injecting a drug solution into a patient or the like. The syringe has a cylinder having an injection needle attached to the distal end and an opening at the proximal end, and a gasket that is inserted into and slides there. A plunger is attached to the gasket. When the plunger protruding from the opening of the syringe is pushed, the gasket slides, and the medicine previously stored in the cylinder can be discharged and injected. This plunger needs to have a length equal to or longer than that of the cylinder so that the gasket can reach the end of the cylinder in order to reliably discharge the chemical solution.

Syringes are used not only by medical doctors and nurses in medical practice, but also when self-injecting medicinal solutions by diabetics and rheumatic patients. Among these, prefilled syringes are prestored in a cylinder in order to prevent contamination of the bacteria of the chemical and simplify the preparation of the chemical.

In Patent Document 1, one end of an ampoule containing a drug suspension is closed with a piston, a metal-containing fixing member is provided on the piston, and a magnetic member such as a bead in the suspension is attracted magnetically, and shaken manually. An administration device is then disclosed in which the mixing member is released to diffuse the suspension. These syringes and administration devices require a plunger to slide the gasket in the cylinder.

The conventional syringe is long due to the plunger. In addition, a flange at the base end of the cylinder to which a finger is applied when the plunger is pushed has to be provided, and the entire width of the syringe is large by this flange.

Such a syringe requires an operation of pressing the proximal end of the plunger with the thumb and pushing it into the cylinder with force while placing the index finger and the middle finger on the front end of the flange during injection. In recent years, needles used for self-injection have been devised to reduce the tip of the needle in order to reduce pain during injection. In addition, a liquid medicine may be injected with a small-diameter injection needle into the upper layer of the skin such as the epidermis or dermis where many immunocompetent cells are present so that the injection amount of a biologic such as a vaccine may be small. When these thin injection needles are used, resistance when the drug solution passes through the injection needle is increased, and strong injection force is required.

It is difficult for patients who have difficulty in this movement because their hands become inconvenient due to illness or because they are old and do not have enough force.

When a syringe is used for self-injection, it is desired that the syringe be small and light so that the patient can inject it in a timely manner, and can be easily injected with little force even when high injection input is required, and easy to carry.

JP-T-2001-511033

The present invention has been made to solve the above-described problems, and an object of the present invention is to provide a syringe that does not have a plunger, is small and excellent in portability, and can discharge a chemical solution with a simple operation.

The syringe of the present invention, which has been made to achieve the above object, includes a cylinder having a cylinder tip at the tip and an opening at the base, a gasket that is inserted into the cylinder and slides by pressing, and the cylinder A syringe that is contained between the cylinder tip and the gasket and is discharged from the cylinder tip by sliding of the gasket, and is fixed to the cylinder and an in-cylinder magnet inserted into the cylinder. Alternatively, a counter magnet that surrounds the cylinder and generates a bias with a magnetic repulsive force generated by causing the same magnetic pole to face the in-cylinder magnet to induce the sliding of the gasket to the tip portion. And at least one of the in-cylinder magnet and the counter magnet is locked to the cylinder, and the bias is accumulated until the locking is released, or the locking is released and then the locking is released. Cause energization So, in which to start the press.

The syringe generates the bias by pressing the in-cylinder magnet and the counter magnet against the magnetic repulsive force while facing each other with the same magnetic poles, and the stopper includes the in-cylinder magnet. It is preferable that the urging force is accumulated by locking.

In the syringe, the in-cylinder magnet is embedded in an in-cylinder holder having a fitting portion on a side surface, and the stopper is fitted in the fitting portion, thereby locking the in-cylinder magnet. Also good.

In the syringe, the fitting portion is recessed in the circumferential direction of the in-cylinder holder, and a groove for locking the in-cylinder holder together with the in-cylinder magnet is depressed in the central axis direction of the in-cylinder holder. It is preferable that the groove to be released is connected.

The syringe may be provided with a hook for releasing the locking by removing the fitting between the stopper and the fitting portion from the outside of the cylinder.

In the syringe, the in-cylinder magnet and the annular counter magnet that surrounds the cylinder together with the in-cylinder magnet are magnetized in the circumferential direction of the respective side surfaces, and magnetic attractive force is generated by opposing the different magnetic poles. On the other hand, it is preferable that the urging is generated after the stopper is released by stopping the counter magnet in a non-rotatable manner.

In the syringe, the in-cylinder magnet and the counter magnet may be radial anisotropic magnets.

In the syringe, the in-cylinder magnet may be embedded in an in-cylinder holder.

The syringe liquid discharge method includes: a cylinder tip at the tip, and a cylinder provided with an opening at the base end; a gasket that is inserted into the cylinder and slides by pressing; and the cylinder tip and the gasket in the cylinder A method of discharging the chemical liquid from a syringe having a chemical liquid stored and discharged from the tip of the cylinder by sliding of the gasket, the step of inserting an in-cylinder magnet into the cylinder, The step of fixing the opposing magnets to be opposed to each other by the magnetic repulsive force so as to be energized or energized by the magnetic repulsive force, or enclosing at least one of the in-cylinder magnet and the opposing magnet. Then, the biasing is accumulated until the locking is released, or the step of generating the biasing after the locking is released, the biasing is performed by the in-cylinder magnet according to the release of the locking. The gasket Said to induce the sliding movement of the tip, and has a step of discharging the chemical solution causing the pressing.

In the syringe of the present invention, the in-cylinder magnet is urged by the magnetic repulsion between the opposing magnet fixed to the cylinder or surrounding the in-cylinder magnet and the in-cylinder magnet inserted in the cylinder, Since it is slid, a plunger inserted into the cylinder and a flange protruding at the base end of the cylinder are not required. Therefore, since the syringe can be shortened and made small, it is particularly convenient for a patient who performs self-injection to carry.

Even if the syringe is a handicapped patient or an elderly person with weak finger strength, the syringe that holds the in-cylinder magnet or the opposing magnet is pushed with a slight force or a finger is applied. The drug solution can be easily discharged and injected simply by pulling or picking and rotating. In addition, it is possible to simply inject at a medical site by a quick and simple operation without malfunction.

This syringe can stop the sliding of the gasket by simply rotating the stopper, and discharge the medicine into small doses for each required dose for injection.

According to the method of discharging the chemical solution from the syringe, the discharge operation of the chemical solution can be easily performed with a simple operation.

It is the disassembled perspective view and perspective view which show one form of the syringe to which this invention is applied. It is a partial notch partial perspective view which shows one form of the syringe to which this invention is applied. It is a perspective view which shows another form of the syringe to which this invention is applied. It is a fragmentary perspective view which shows another form of the syringe to which this invention is applied. It is a fragmentary perspective view which shows another form of the syringe to which this invention is applied. It is a fragmentary perspective view which shows another form of the syringe to which this invention is applied. It is a perspective view which shows another form of the syringe to which this invention is applied, and a model perspective view explaining the position of a magnetic pole.

Hereinafter, modes for carrying out the present invention will be described in detail, but the scope of the present invention is not limited to these embodiments.

FIG. 1 shows an embodiment of the syringe 10 of the present invention. FIG. 1A is an exploded perspective view of the syringe 10, and FIG. 1B is a perspective view showing a state in which the syringe 10 is assembled. The syringe 10 includes a cylinder 30, an injection needle 22 joined to the cylinder tip 31, a fixed holder 47 fitted in the opening 34 of the cylinder 30, and a stopper 51 that surrounds a part of the side wall of the cylinder 30. ing.

The cylinder 30 is formed of a transparent material so that the inside can be visually confirmed. The tube 30 is formed with a tube tip 31 having a reduced diameter at a distal end portion and an opening 34 provided at a proximal end portion. A gasket 42 is inserted into the cylinder 30. A chemical solution 41 is accommodated between the tube tip 31 and the gasket 42 in the tube 30. The gasket 42 is in close contact with the inner wall surface of the cylinder 30 in an airtight manner, thereby preventing the chemical liquid 41 from leaking. The gasket 42 is integrated with a substantially cylindrical in-cylinder holder 44 in which an in-cylinder magnet 43 is embedded.

In the syringe, the in-cylinder holder 44 and the inner wall surface of the cylinder 30 are hooked so as not to rotate. For example, a linear rotation piece 32 a parallel to the central axis of the cylinder 30 slightly protrudes from the inner wall surface of the cylinder 30. The latching portion 44a that is recessed on the side surface of the in-cylinder holder 44 is provided in parallel with the central axis of the in-cylinder holder 44 and is hooked to the rotation piece 32a. Thereby, the rotation piece 32a and the latching portion 44a prevent the in-cylinder holder 44 from rotating as the stopper 51 rotates. The rotation stop piece 32a forms a smooth arc so as not to damage the gasket 42.

The tube tip 31 has a diameter smaller than that of the body portion 32. The injection needle 22 protrudes from the tip. The injection needle 22 penetrates the tube tip 31 and communicates the inside and outside of the tube 30. A cap 21 that is an elastic body is attached to the tube tip 31. The cap 21 is pierced with an injection needle 22. Thereby, the cylinder 30 is sealed, and the chemical solution 41 in the cylinder 30 is prevented from leaking or being contaminated when the syringe 10 is transported or stored.

FIG. 2 (a) shows a partially cutaway partial perspective view of the syringe 10. FIG. On the end face of the in-cylinder holder 44 on the gasket 42 side, a flange portion 44b having a T-shaped cross section protrudes. The flange portion 44b is inserted into a hole 42a formed in the end surface of the gasket 42 on the cylinder holder 44 side. The gasket 42 is molded from an elastic material and is highly flexible. Thereby, the collar part 44b can be easily pushed into the hole 42a. The in-cylinder holder 44 is inserted into the cylinder 30 together with the gasket 42.

The in-cylinder magnet 43 is a permanent magnet having magnetic poles at both end surfaces, and the surface on the distal end side of the cylinder 30 is an S pole and the surface on the proximal end side is an N pole.

The cylinder holder 44 has a fitting portion 45 on the side surface. The fitting portion 45 is a groove in which a locking groove 45 a that is recessed in the circumferential direction of the in-cylinder holder 44 and a release groove 45 b that is recessed in the central axis direction of the in-cylinder holder 44 are connected at a substantially right angle. Two fitting portions 45 are provided in line symmetry with the central axis of the in-cylinder holder 44 as the symmetry axis. A locking groove 45a is exposed from the through hole 33 penetrating the side wall of the cylinder 30 (see FIG. 1B).

A fixed holder 47 in which a counter magnet 46 is embedded is fitted in the opening 34 and fixed by adhesion or heat welding. The counter magnet 46 is a permanent magnet having magnetic poles at both end surfaces, and the surface on the distal end side of the cylinder 30 is an N pole and the surface on the proximal end side is an S pole. The counter magnet 46 generates a magnetic repulsive force that generates a mutual repelling force by causing the in-cylinder magnet 43 and the N poles to face each other. The in-cylinder magnet 43 is urged by being pressed against the opposing magnet 46 against this magnetic repulsion.

The stopper 51 has a semi-cylindrical shape. On the inner wall surface of the stopper 51, two locking projections 52 protrude in symmetrical positions. The locking projection 52 is fitted into the locking groove 45 a through the through hole 33. Thereby, the stopper 51 holds the in-cylinder magnet 43 and keeps the bias of the in-cylinder magnet 43 so that the gasket 42 is not pressed until the chemical solution 41 is discharged. The stopper 51 can be rotated in the direction of the arrow shown in FIG. The outer periphery of the stopper 51 is recessed so that it can be easily picked with a finger.

As shown in FIG. 2A, the locking projection 52 of the stopper 51 is locked to the locking groove 45a, but can be moved to the release groove 45b by the rotation of the stopper 51. FIG. 2B shows a partially cutaway partial perspective view of the syringe 10 released from the locking by the stopper 51. When the latching is released, the in-cylinder magnet 43 presses and slides the gasket 42 together with the in-cylinder holder 44 toward the distal end portion of the cylinder 30 by the accumulated bias. The drug solution 41 can be discharged from the injection needle 22 through the tube tip 31 by the sliding gasket 42.

Thus, even if the syringe 10 does not have a plunger that presses the gasket 42 and a proximal flange that hooks a finger when the plunger 10 is pressed, the syringe 41 can discharge the chemical solution 41 contained in the cylinder 30. . As a result, the overall length of the syringe 10 can be shortened compared to the case where a plunger is used. Moreover, since there is no possibility that the plunger is accidentally pulled out, the chemical solution 41 is not contaminated while being sealed, and the syringe 10 is safe.

The strength of the magnetic repulsion generated between the in-cylinder magnet 43 and the counter magnet 46 depends on the surface magnetic flux density of the magnet under the condition that the shape and surface area of the magnets are constant. The higher the surface magnetic flux density, the stronger the magnetic repulsion, and vice versa. For this reason, the surface magnetic flux density exerts an urging force on the in-cylinder magnet 43 and affects the force that presses and slides the gasket 42. The surface magnetic flux density of the magnet is preferably from 100 to 30000 G, more preferably from 100 to 20000 G, and even more preferably from 1000 to 10000 G. If the surface magnetic flux density is smaller than this range, the magnetic repulsive force is insufficient, and the in-cylinder magnet 43 cannot be sufficiently biased, so that the gasket 42 cannot be pressed. On the other hand, if it is larger than this range, the magnet is a strong magnetic force, so that it becomes expensive and not economically practical, and there is a risk of causing malfunctions in peripheral medical devices due to the magnetism of the magnet. The magnetic flux density of the magnet is appropriately set according to the outer diameter of the cylinder 30, the sliding resistance of the gasket 34, the viscosity of the drug solution 33, the inner diameter and length of the injection needle 21, the site to be injected, and the like.

As the magnets of the in-cylinder magnet 43 and the counter magnet 46, a neodymium magnet, an alnico magnet, a samarium cobalt magnet, or a ferrite magnet can be given. Among these, neodymium magnets have the advantage of large magnetic repulsion. Alnico magnets have excellent mechanical strength and can be molded into any shape. Since the surface magnetic flux density hardly changes depending on the temperature, the samarium cobalt magnet can be used at any temperature.

The syringe 10 shown in FIG. 1 is manufactured as follows. First, the injection needle 22 is directly joined to the tube tip 31 while the tube 30 is formed by insert molding. The cap 21, which is an elastic body, is attached to the tube tip 31 by piercing the injection needle 22 straight, and the needle tip of the injection needle 22 is sealed. This is subjected to sterilization such as high-pressure steam sterilization. Next, a desired chemical solution 41 is filled into the cylinder 30. The flange portion 44b of the in-cylinder holder 44 is pushed into the hole 42a of the gasket 42 to integrate them. The gasket 42 and the in-cylinder holder 44 are pushed into the cylinder 30 and the drug solution 41 is sealed while the rotation piece 32a is fitted in the latching portion 44a that is recessed on the side surface of the in-cylinder holder 44. The material of the stopper 51 is somewhat more flexible than the material of the cylinder 30. The stopper 51 is bent once and pushed open, and both locking projections 52 are fitted into the locking grooves 45 a through the through holes 33 of the cylinder 30. Then, the stopper 51 is restored by its own elasticity. Both the locking projections 52 are caught in the locking groove 45 a, and the in-cylinder holder 44 is locked together with the in-cylinder magnet 43. A fixing holder 47 integrated with the counter magnet 46 is fitted from the opening 34, pushed in so as to oppose the magnetic repulsive force, and fixed by bonding or heat welding with an adhesive. The syringe 10 is housed in a blister packaging material and sterilized as necessary. The syringe 10 filled with the chemical solution 41 may be sterilized and then stored in the blister packaging material.

The syringe 10 is used as follows when the patient himself uses it for self-injection. The doctor / nurse or the patient to be self-injected removes the mount of the blister packaging material, takes out the syringe 10, and removes the cap 21 fitted to the tube tip 31. The body 10 is held and the syringe 10 is held. The injection needle 22 is punctured, for example, subcutaneously at a site to be injected, such as the upper arm, abdomen, or thigh. The stopper 51 is rotated in the direction of the arrow shown in FIG. 2A while fixing the syringe 10 so that the injection needle 22 does not come out of the site to be injected. The locking projection 52 moves from the locking groove 45a to the release groove 45b to release the lock, slides on the release groove 45b, and finally comes out of the release groove 45b. As a result, the in-cylinder magnet 43 is unlocked, and the in-cylinder magnet 43 presses the gasket 42 together with the in-cylinder holder 44 by urging by the magnetic repulsive force, and the gasket 42 slides toward the cylinder tip 31. The drug solution 41 is discharged from the cylinder 30 through the injection needle 22 and injected into the patient's body. The syringe 10 together with the injection needle 22 is removed from the body. The syringe 10 is discarded as infectious medical waste. The stopper 51 may be removed from the cylinder 30 and reused before the syringe 10 is discarded. In this case, the chemical solution 41 may be in a cartridge-type refill form.

1 and 2 show an example in which the in-cylinder holder 44 in which the in-cylinder magnet 43 is embedded and the gasket 42 are integrated. However, both are separated in an unused state, and the in-cylinder magnet 43 is It may be inserted between the gasket 42 and the opening 34 (not shown). In this case, when the in-cylinder holder 43 is released from being locked by the rotation of the stopper 51, the in-cylinder holder 44 abuts on the gasket 42 by this urging and presses the gasket 42. Slide. Thereby, the chemical liquid 41 is discharged.

A slit (not shown) that connects the through hole 33 and the periphery of the opening 34 may be provided on the side wall of the body portion 32. By fitting the locking projection 52 into the slit from the opening 34 and sliding it to the tip of the cylinder 30, the locking projection 52 can be fitted into the locking groove 45a without spreading.

The injection needle 22 may be joined to a needle base (not shown). The needle 22 is connected to the inside and outside of the cylinder 30 by attaching the needle base to the cylinder tip 31.

FIG. 3 shows a perspective view of another embodiment of the syringe 10. The fixed holder 47 has two claws 47a projecting symmetrically from the peripheral edge of the end of the tube tip. The fixing holder 47 is fixed by adhesion or welding by being fitted into the opening 34 while the claw 47a is fitted in the release groove 45b. The claw 47 a prevents the in-cylinder holder 44 from rotating as the stopper 51 rotates. The release groove 45b has a function of preventing the in-cylinder holder 44 from rotating when the stopper 51 is rotated, and a function of moving the in-cylinder holder 44 by sliding the locking projection 52 when the stopper 51 is fully rotated. Have both. Therefore, the number of parts can be reduced.

FIG. 4 shows a perspective view of another embodiment of the syringe 10. The syringe 10 can slide the gasket 42 in stages. The syringe 10 is fixed to the cylinder 30, the gasket 42 inserted therein, the cylinder holder 44 in which the cylinder magnet 43 is embedded, and the opening magnet 34, and the counter magnet 46 is embedded. A fixed holder 47 and a stopper 51 are provided. The in-cylinder magnet 43 and the counter magnet 46 are opposed to each other with N poles. The in-cylinder magnet 43 is urged by a magnetic repulsion generated between the magnets.

A fitting portion 45 is provided on the side surface of the in-cylinder holder 44. The fitting portion 45 is a groove having locking

grooves

45 a and 45 c that are recessed in the circumferential direction of the in-cylinder holder 44 and

release grooves

45 b and 45 d that are recessed in the central axis direction of the in-cylinder holder 44. Two fitting portions 45 are provided in line symmetry on the side surface of the in-cylinder holder 44. The fitting portion 45 is connected to the gasket 42 from the side of the first locking groove 45a, the first release groove 45b, the second lock groove 45c, and the second release groove 45d in a substantially right angle. Yes.

As shown in FIG. 4A, the locking protrusion 52 locks the in-cylinder holder 44 together with the in-cylinder magnet 43 by being fitted in the first locking groove 45a. The in-cylinder magnet 43 accumulates urging force by being pressed and locked against the magnetic repulsive force generated between the opposing magnet 46. When the stopper 51 rotates in the direction of the arrow, the locking projection 52 moves to a substantially right angle portion where the first locking groove 45a and the first release groove 45b are connected (FIG. 4B). . The in-cylinder magnet 43 thus released from the lock presses the gasket 42 toward the cylinder tip 31 by the accumulated bias. The locking projection 52 slides on the first release groove 45b, moves to a substantially right angle portion where the second locking groove 45c is connected, and comes into contact with the locking groove 45c (FIG. 4C). )). Thereby, the in-cylinder magnet 43 is locked again. Half of the amount of the chemical solution 41 initially contained in the cylinder 30 is discharged.

In FIG. 4C, the in-cylinder magnet 43 locked by the stopper 51 is separated from the opposing magnet 46 as compared with FIG. The magnet 43 is still accumulating bias due to magnetic repulsion. When the stopper 51 is rotated in the direction of the arrow shown in FIG. 4 (c), the locking projection 52 is positioned at a substantially right angle portion where the second locking groove 45c and the second release groove 45d are connected. Move (FIG. 4D). The locking projection 52 slides in the second release groove 45 b and does not fit into the fitting portion 45 through the proximal end of the in-cylinder holder 44. When the gasket 42 is pressed and slid by the in-cylinder magnet 43 and reaches the tip of the cylinder 30, the discharge of the chemical liquid 41 is completed (FIG. 4 (e)).

Thus, the syringe 10 can discharge | release the chemical | medical solution 41 in steps by rotating the stopper 51 in multiple numbers, when the fitting part 45 has multiple locking grooves and cancellation | release grooves. Therefore, the gasket 42 that slides when the stopper 51 is rotated once can set the amount of the chemical solution 41 to be discharged to a dose per time. As a result, several doses of the drug solution 41 can be stored in the cylinder 30 in advance, and can be discharged and injected for each dose without confirming the discharge amount with a scale or the like.

FIG. 5 shows another embodiment of the syringe 10. FIG. 5A is a perspective view showing the manufacturing process of the syringe 10. The stopper 51 has an arch shape, and the locking projection 52 and the support projection 53 protrude from the inner peripheral surface thereof. The

protrusions

52 and 53 protrude from the stopper 51 in correspondence with the through hole 33 opened in the cylinder 30 and the recessed portion 32b that is recessed. The locking projection 52 is fitted into the fitting portion 45 through the through hole 33 to lock the in-cylinder holder 44. The support protrusion 53 is fitted into a recessed portion 32 b that is recessed in a part of the outer wall of the body portion 32. The stopper 51 is supported by the support protrusion 53 so that it does not fall off even when the locking protrusion 52 is removed. One end of the stopper 51 on the side of the locking projection 52 is connected to a pressing hook 54 that has warped from an arch-shaped curve. Anti-slip ribs are provided on the surface of the pressing hook 54. Since the stopper 51 is formed of a flexible material, it can be restored to its original shape even if it is slightly bent.

The stopper 51 is attached after the chemical solution 41, the gasket 42 and the in-cylinder holder 44 are inserted into the cylinder 30. First, the support protrusion 53 is fitted into the recess 32b. With this fitting as a fulcrum, the locking projection 52 is fitted into the fitting portion 45 while the stopper 51 is expanded and bent. The in-cylinder magnet 43 is locked by the stopper 51. Next, the fixing holder 47 in which the counter magnet 46 is embedded is fitted into the opening 34 and fixed by adhesion or heat welding, with the in-cylinder magnet 43 and the N poles facing each other. The in-cylinder magnet 43 is urged by a magnetic repulsion generated between the counter magnet 46 and the urging force is accumulated by the locking by the stopper 51.

For example, when self-injecting the drug solution 41, the patient punctures the skin with the injection needle 22, and then presses the pressing hook 54 in the direction of the arrow as shown in FIG. The locking projection 52 is detached from the fitting portion 45 when the stopper 51 is bent with the fitting portion of the support projection 53 and the recess 32b as a fulcrum. As a result, the in-cylinder magnet 43 is unlocked and presses the gasket 42 with the accumulated bias. As shown in FIG. 5C, the stopper 51 returns to its original shape due to its flexibility. The chemical liquid 41 is discharged by the gasket 42 that slides with the bias of the in-cylinder magnet 43.

The cylindrical holder 44 is provided with two symmetrical fitting portions 45 as the through holes 33 instead of the recesses 32b and as the locking projections 52 instead of the support projections 53, so that the in-cylinder holders are provided at a plurality of locations. The in-cylinder magnet 43 may be locked together with 44. The in-cylinder magnet 43 can be more reliably locked by fitting the locking protrusions 52 and the fitting portions 45 in a plurality.

FIG. 6 shows another embodiment of the syringe 10. The stopper 51 has a pull-out hook 56 and a locking pin 55 connected on the outer periphery thereof. The pull-out hook 56 has a ring shape so that it can be easily pulled by hooking a finger. Two through holes 33 are formed symmetrically on the side wall of the cylinder 30. The fitting portion 45 is a hole that penetrates the in-cylinder holder 44. The locking pin 55 is fitted through the fitting portion 45 through the one through hole 33, and the tip of the locking pin 55 projects out of the cylinder 30 through the other through hole 33. As a result, the in-cylinder magnet 43 urged by the magnetic repulsion generated between the counter magnet 46 is locked and accumulated. The tip of the locking pin 55 is slightly bent. When the force in the direction of the arrow is unexpectedly applied to the pulling hook 56, the bent tip prevents the locking pin 55 from being pulled out unexpectedly by being caught by the fitting portion 45.

When the extraction hook 56 is pulled in the direction of the arrow during the discharge of the chemical solution 41, the tip of the locking pin 55 is bent and pulled into the fitting portion 45, and finally the stopper 51 comes off and comes off. As a result, the in-cylinder magnet 43 is unlocked, and presses and slides the gasket 42. The drug solution 41 is discharged from the injection needle 22 through the tube tip 31. Note that the pull-out hook 56 may be formed to have a large inner diameter or a hook shape so that several fingers can be hooked.

As shown in FIGS. 5 and 6, if the stopper 51 has a pressing hook 54 and a pulling hook 56, the drug solution 41 can be discharged and injected simply by pushing or pulling the stopper. Therefore, even patients with rheumatism, such as patients with hand movement difficulties or weak grip, and elderly people can easily inject themselves without the assistance of their family members. The burden on the patient during self-injection can be reduced.

FIG. 7 shows a perspective view and a schematic perspective view of another embodiment of the syringe 10. As shown to Fig.7 (a), the syringe 10 has the cylinder 30 which accommodated the chemical | medical solution 41, and the cylindrical stopper 51. As shown in FIG. A gasket 42 and an in-cylinder holder 44 in which an in-cylinder magnet 43 is embedded are inserted into the cylinder 30. A counter magnet 46 having an annular shape is embedded in the stopper 51 coaxially with the stopper 51. Both the in-cylinder magnet 43 and the counter magnet 46 are radial anisotropic magnets magnetized to four poles in the respective circumferential directions. On the side wall of the cylinder 30, the collar portion 32c protrudes.

The stopper 51 is inserted into the cylinder 30 from the base end of the cylinder 30, and the end surface of the cylinder 30 on the distal end side is brought into contact with the flange portion 32c. The stopper 51 can rotate coaxially with the cylinder 30. The outer periphery of the stopper 51 is recessed in the middle so that it can be easily picked or pinched with fingers and rotated.

The opening 34 is closed with a lid 57 fitted. The lid 57 has a shape in which the base end of the ring portion 57a fitted in the opening 34 is connected to the presser portion 57b having a larger diameter. An air hole 57 c is opened at the center of the lid 57. The air hole 57c is for introducing air into the cylinder 30 on the base end side of the gasket 42 when the gasket 42 slides toward the cylinder tip 31, so that the gasket 42 slides smoothly. is there. The presser portion 57 b protrudes slightly from the side wall of the cylinder 30 and is in contact with the stopper 51. The stopper 51 does not fall out of the cylinder 30 by being sandwiched between the collar portion 32c and the pressing portion 57b.

The in-cylinder magnet 43 is restricted in rotation within the cylinder 30 by the hooking portion 44 a that is recessed on the side surface of the in-cylinder holder 44 and the locking piece 32 a that protrudes from the inner wall of the cylinder 30 being engaged with each other. Yes.

7 (b) and 7 (c) are schematic perspective views showing the positions of the magnetic poles of the in-cylinder magnet 43 and the counter magnet 46. FIG. As shown in FIG. 7B, the counter magnet 46 surrounds the in-cylinder magnet 43 while the in-cylinder magnet 43 and the different magnetic poles are opposed to each other. The rotation of the in-cylinder magnet 43 is prevented by the hooking of the stop piece 32a and the hooking portion 44a, and the magnetic repulsive force generated between the in-cylinder magnet 43 is attracted. The counter magnet 46 is locked so as not to rotate. The in-cylinder magnet 43 protrudes somewhat toward the cylinder tip side than the counter magnet 46.

When the stopper 51 is rotated, the opposing magnet 46 is unlocked. As shown in FIG. 7C, the counter magnet 46 is opposed to the cylinder magnet 43 with the same magnetic poles. The in-cylinder magnet 43 generates a magnetic repulsive force with the counter magnet 46 and is biased thereby to press the gasket 42. The drug solution 41 is discharged from the injection needle 22 through the tube tip 31 by sliding of the pressed gasket.

In this way, the syringe 10 can discharge the liquid medicine 41 simply by pinching the stopper 51 with a finger and moving the wrist with a slight force. Therefore, even a patient who is difficult to perform a fine operation with a fingertip can be easily injected. Further, since it is not necessary to use an adhesive to fix the fixing holder 47 in which the opposing magnet 46 is embedded to the cylinder 30, there is no possibility of contaminating the chemical liquid 41, and the syringe 10 is hygienic.

FIG. 7 shows an example in which the in-cylinder magnet 43 and the counter magnet 46 are magnetized with four poles in their circumferential direction. However, these magnets only need to be magnetized with at least two poles, It may be 6 poles or more.

Although the example which suppresses rotation of the gasket 42 by the rotation piece 32a and the latching | locking part 44a or the nail | claw 47a was shown, these are rotation of the gasket 42 by friction with the gasket 42 and the inner wall of the cylinder 30. If it does not occur, it may not be provided.

The drug solution 41 accommodated in the cylinder 30 is, for example, a sugar solution injection solution such as glucose, an electrolyte correction injection solution such as sodium chloride or potassium lactate, an antiarrhythmic agent, an anticonvulsant, an insulin preparation, a protein preparation, an antibody drug, Antirheumatic drugs, bronchodilators, contrast agents, steroids, proteolytic enzyme inhibitors, fat emulsions, antibiotics, anticancer agents, heparin calcium, anesthetics, antibody drugs and the like can be mentioned. Influenza, tetanus, pneumococci, polio, Japanese encephalitis, rubella, measles, yellow fever, hives, hepatitis, chickenpox, rabies, rotavirus, mumps, cervical cancer prevention, MQ, DT and DPT vaccines Such biopharmaceuticals.

The inner diameter of the cylinder 30 is preferably 5 to 30 mm. If the inner diameter is smaller than this range, it is difficult to mold the cylinder 30. If it is larger than this range, the force for sliding the gasket 42 becomes large and a strong magnetic repulsive force is required. Therefore, the in-cylinder magnet 43 and the counter magnet 46 must be enlarged, and the syringe 10 becomes heavy. Portability is impaired.

The syringe 10 may be sterilized by any of ethylene oxide gas, γ rays, electron beams, and high pressure steam in an autoclave. The sterilization method and procedure are appropriately selected according to the material of the cylinder 30, the type and stability of the liquid medicine 41 to be injected, the size and shape of the syringe 10, and the like.

The material of the cylinder 30, the in-cylinder holder 44, the fixing holder 47, the stopper 51, the pressing hook 54, the locking pin 55, the pulling hook 56, and the lid 57 is chemical resistance, gas / bacteria barrier property, and safety to living bodies. Are selected from the viewpoint of For example, polyolefin resin such as polyethylene, polypropylene and cyclic polyolefin; polystyrene; polycarbonate; polyester such as polyethylene terephthalate; In particular, when sterilization is performed in an autoclave, it is preferable to use a resin having high heat resistance, such as polypropylene or polycarbonate, as these materials. Further, as the material of the cylinder 30, it has a high transparency so that the drug solution 41 accommodated in the cylinder 30 can be visually recognized from the outside, has little interaction with the drug solution 41, and is strongly gripped when the drug solution 41 is administered. It is preferable to use a cyclic olefin homopolymer or a cyclic olefin copolymer, which is a resin that does not bend and does not collapse even when pressed. As the molding method, an injection molding method, a blow molding method, a thermoforming method, or the like can be used, and among these, the injection molding method is preferable.

The materials of the cap 21 and the gasket 42 are selected from the same viewpoint as described above. For example, rubber materials such as olefin-based, polyurethane-based, polyester-based, polyamide-based or styrene-based thermoplastic elastomers, natural rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber are used.

The syringe of the present invention is used for injecting a drug solution into a patient.

The chemical solution discharging method of the present invention is used for self-injection or injection at a medical institution.

10: Syringe, 21: Cap, 22: Injection needle, 30: Tube, 31: Tube tip, 32: Body, 32a: Rotating piece, 32b: Recess, 32c: Gutter, 33: Through hole, 34: Opening, 41: chemical solution, 42: gasket, 42a: hole, 43: in-cylinder magnet, 44: in-cylinder holder, 44a: latching part, 44b: collar part, 45: fitting part, 45a, 45c: locking groove, 45b , 45d: release groove, 46: counter magnet, 47: fixed holder, 47a: claw, 51: stopper, 52: locking protrusion, 53: support protrusion, 54: pressing hook, 55: locking pin, 56: pulling hook 57: lid, 57a: ring part, 57b: presser part, 57c: air hole

Claims

A cylinder having a tube tip at the distal end and an opening at the base end, a gasket that is inserted into the cylinder and slides by pressing, and is accommodated in the cylinder between the tube tip and the gasket and slides on the gasket. A syringe having a liquid medicine discharged from the tube tip by movement,
An in-cylinder magnet inserted into the cylinder;
A magnetic repulsive force that is fixed to or surrounds the cylinder and is caused to face each other by the same magnetic pole as the in-cylinder magnet, and generates a bias to induce the sliding of the gasket to the tip portion. An opposing magnet to
And at least one of the in-cylinder magnet and the counter magnet is locked to the cylinder, and the urging is accumulated until the locking is released, or the locking is released and then the attachment is performed. A syringe characterized by causing a force to start the pressing.
The in-cylinder magnet and the counter magnet are pressed against each other against the magnetic repulsive force while facing each other with the same magnetic poles, and the bias is generated, and a stopper locks the in-cylinder magnet. The syringe according to claim 1, wherein the urging force is accumulated.
The in-cylinder magnet is embedded in an in-cylinder holder having a fitting portion on a side surface, and the stopper is engaged with the fitting portion, thereby locking the in-cylinder magnet. The syringe according to claim 2.
A groove in which the fitting portion is recessed in the circumferential direction of the in-cylinder holder and the in-cylinder magnet is locked with the in-cylinder magnet, and a groove is recessed in the central axis direction of the in-cylinder holder and the locking is released. The syringe according to claim 3, which is connected to each other.
4. The syringe according to claim 3, wherein the stopper is provided with a hook for releasing the engagement by removing the fitting of the stopper and the fitting portion from the outside of the cylinder.
The in-cylinder magnet and the annular counter magnet surrounding the cylinder together with the in-cylinder magnet are magnetized in the circumferential direction of the respective side surfaces, and a magnetic attractive force is generated by opposing the different magnetic poles, and a stopper The syringe according to claim 1, wherein the biasing is generated after the locking is released by locking the counter magnet in a non-rotatable manner.
The syringe according to claim 6, wherein the in-cylinder magnet and the counter magnet are radial anisotropic magnets.
The syringe according to claim 7, wherein the in-cylinder magnet is embedded in an in-cylinder holder.
A cylinder with a tube tip at the tip and an opening at the base end, a gasket that is inserted into the cylinder and slides by pressing, and a sliding of the gasket that is accommodated between the cylinder tip and the gasket in the cylinder And a method for discharging the chemical solution from a syringe having the chemical solution discharged from the tube tip,
Inserting an in-cylinder magnet into the cylinder;
A step of fixing the opposing magnets facing the in-cylinder magnets with the same magnetic poles to be energized or energized by their magnetic repulsive force or surrounding the cylinders;
Locking at least one of the in-cylinder magnet and the counter magnet, storing the bias until the lock is released, or generating the bias after releasing the lock;
In response to the release of the locking, the biasing has a step of inducing the sliding of the gasket to the tip by the in-cylinder magnet to cause the pressing to discharge the chemical solution. A method for discharging a chemical solution.