WO2014064272A1 - Bloc d'appât rodenticide sans cire - Google Patents

Bloc d'appât rodenticide sans cire Download PDF

Info

Publication number
WO2014064272A1
WO2014064272A1 PCT/EP2013/072442 EP2013072442W WO2014064272A1 WO 2014064272 A1 WO2014064272 A1 WO 2014064272A1 EP 2013072442 W EP2013072442 W EP 2013072442W WO 2014064272 A1 WO2014064272 A1 WO 2014064272A1
Authority
WO
WIPO (PCT)
Prior art keywords
bait
rodenticide
seed
weight
block according
Prior art date
Application number
PCT/EP2013/072442
Other languages
English (en)
Inventor
Lars Weichel
Roland Stephen TWYDELL
Sharon Hughes
Benjamin CHARNOCK
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of WO2014064272A1 publication Critical patent/WO2014064272A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A01N25/004—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits rodenticidal

Definitions

  • the present invention relates to a wax-free rodenticidal bait block, to method of manufacturing this and to its use in the control of rodents, particularly rats and mice.
  • Rodent populations especially those of rats and mice, are controlled principally because of the economic damage they cause. Rats and mice are responsible for large scale food/feed consumption and spoilage and cause structural damage to buildings and other damage resulting from their habits of chewing and digging. Infestations by rats and mice are often controlled by the administration of poison formulations. Bait blocks are often used to avoid the scattering of poisoned bait and because they are generally more resistant to damp or wet conditions.
  • Rodenticidal block baits have traditionally been manufactured by dispersing feed materials and one or more rodenticides in a hard or semi-sofid wax, typically paraffin wax, binder. The mixture is then moulded or formed into suitably sized and shaped blocks which can be placed in a location close to signs of rodent activity but inaccessible to children and non-target animals or in tamper-proof bait stations.
  • Rodents have continuously growing incisors and the natural behaviour of rodents is to gnaw hard materials in order to wear down these teeth to keep them short.
  • Conventional wax-based rodent blocks do not have sufficient hardness to satisfy the rodents' natural desire to gnaw.
  • GB-A-21 15698 discloses a rodenticidal block bait consisting essentially of brittle-hard polyvinyl acetate, or of a brittle- hard copolymer of vinyl acetate and acrylic acid ester, methacrylic acid ester and/or acrylonitrile, and a foodstuff treated with a rodenticidal poison and dispersed in the polymer carrier.
  • the polymer component constitutes 4 to 30% by weight of the block bait and the actual examples described in the document describe baits comprising 20% by weight of polyvinyl acetate, or vinyl acetate/acrylic acid ester copolymer or vinyl acetate/acrylonitrile copolymer.
  • the block bait has adequate brittle hardness suitable for gnawing and has a high level of patentability.
  • WO-A-96/03037 discloses a rodenticidal bait in the form of agglomerated granules comprising a cereal base comprising a ground cereal, an anticoagulant rodenticide and water-soluble film-forming binder.
  • the process of manufacture of the rodenticidal bait according to WO-A-96/03037 typically comprises mixing the dry ground cereals with rodenticide and then spraying the mixture with an aqueous solution of the film-forming binder.
  • the wet granular mixture may then be formed into blocks and allowed to dry or, alternatively, may be dried and then mixed with molten fat or wax and then moulded into blocks which are then allowed to cool and solidify.
  • film-forming binders examples include cellulose ethers, starch, polyvinyl alcohol, polyvinyl pyrrolidone, various gums such as guar, xanthan and locust bean gum, and polyacrylates although the preferred film- forming binder is said to be hydroxypropyl cellulose.
  • US-A-2005/0048095 discloses a pesticide consisting of disc-shaped pellets formed from a composition comprising, inter alia, starch and an aqueous dispersion of polyacrylate.
  • the bait blocks of the prior art and their methods of manufacture are found to suffer from various disadvantages.
  • a large amount, e.g. 20% by weight, of polymer is used to prepare a brittle-hard block.
  • the hardness of the bait blocks in WO-A-96/03037 and in US-A- 2005/0048095 is not discussed.
  • Bait blocks containing wax or fat not only fail to satisfy hardness requirements but also lack stability at elevated temperatures.
  • many of the bait blocks according to the prior art are still not sufficiently palatable to rodents to ensure that they retain an on-going interest in the bait.
  • some processes for manufacturing prior art bait blocks require extended drying times or hardening times and are not sufficiently simple and/or reliable for industrial operation. It is the object of the present invention to provide rodenticidal bait blocks and a method for manufacturing these which overcome the disadvantages of the prior art.
  • the present invention provides wax-free bait blocks which contain low amounts of polymeric binder and which have good palatability and hardness properties and which have high temperature stability.
  • the present invention provides a rodenticidal bait block comprising a foodstuff for the rodent comprising edible seed and/or cereal, at least one rodenticide, and a polymeric binder wherein the polymeric binder comprises a polymer based on an acrylic ester and acrylonitrile and is present in an amount of from 1 to 18% by weight, preferably 1 to 10%, more preferably 1 to 5% by weight, based on the total weight of the bait block.
  • the polymeric binder consists essentially of a polymer based on an acrylic ester and acrylonitrile, preferably one based on an alkyl acrylic ester, acrylonitrile and (meth)acrylic acid.
  • the bait block of the invention does not contain a wax binder. Accordingly, disadvantages noted in the prior art arising from the use of a wax binder are thereby avoided.
  • rodenticidal bait blocks according to the invention are highly palatable to rodents, particularly rats, yet and have adequate hardness and high stability despite the use of only a low content of polymeric binder.
  • the rodenticidal bait block of the present invention comprises a foodstuff for the rodent.
  • the foodstuff contains edible seed or cereal or their mixtures.
  • edible seeds include poppy seed, sunflower seed and sesame seed.
  • cereal we mean the edible grain or seed of crops, generally those of the family Poaceae, that are harvested for their dry grain or seed.
  • cereals include, but are not limited to, wheat, barley, maize, sorghum, oats, rice, rye, millet and canary seed.
  • the bait block of the invention will contain more than one seed and/or cereal in order to present the rodent with different flavours in the same block.
  • the cereal used in the bait block will be in the form of whole grains or seeds, ground grains or seeds, cut or comminuted grains or seeds and mixtures of these.
  • cut or comminuted grains include pinhead oatmeal, cut wheat and corn grits.
  • the bait block of the invention is in the form of whole grains or seeds, ground grains or seeds, cut or comminuted grains or seeds and mixtures of these. Examples of cut or comminuted grains include pinhead oatmeal, cut wheat and corn grits.
  • the bait block of the invention will be in the form of whole grains or seeds, ground grains or seeds, cut or comminuted grains or seeds and mixtures of these. Examples of cut or comminuted grains include pinhead oatmeal, cut wheat and corn grits.
  • 5 will contain a mixture of whole grain or seed with ground or cut grain or seed in order to present the rodent with a variety of chew and bite textures in the same block.
  • a mixture of canary seed with cut wheat grains presents the rodent with a mixture of flavours and textures which is sufficiently attractive to the rodent to retain interest.
  • the total content of cereal in the bait blocks is typically from 50 to 99% by weight, preferably from 70 to 98% and more preferably from 80 to 98% by weight.
  • the bait blocks of the present invention contain at least one rodenticidally-active substance.
  • the rodenticidally-active substance may be i s an anticoagulant rodenticide or a non-anticoagulant rodenticide.
  • anticoagulant rodenticides that may be used in the bait block of the invention include one or more of difenacoum, brodifacoum, flocoumafen, bromadiolone, difethialone, warfarin, coumatetralyl, chlorophacinone, diphacinone, coumachlor, coumafuryl and pindone.
  • a preferred anticoagulant rodenticide 0 for use in the present invention is difenacoum.
  • non- anticoagulant rodenticides examples include vitamin D, including ergocalciferol (vitamin D 2 ) or cholecalciferol (vitamin D 3 ), and alphachlorolose.
  • the non-anticoagulant rodenticide, if used is ergocalciferol or cholecalciferol or a mixture thereof.5
  • the rodenticidally-active substance used in the bait block of the invention will be selected from difenacoum and vitamin D.
  • an anticoagulant rodenticide will be used in the present invention in an amount in the range of from 0.001 to 0.03% by weight, preferably 0.001 to 0.025% and more preferably 0.0025 to 0.025% by weight,0 based on the total weight of the bait block.
  • Vitamin D cholesterol
  • the actual amount used will, of course, depend on the identity of the rodenticidally-active substance and on the target species.
  • the rodenticidally-active substance is provided, in the bait block, on or in the, or part of the, seed or cereal. It is generally known in the art to use, as a rodent bait, wheat grains or cut wheat grains treated with a rodenticide such as difenacoum. Thus, according to such an embodiment, the seed, grain or cut grain in the bait block is pre- treated with the rodenticidally-active substance prior to incorporation into the block.
  • WO 2007/031796 It has been shown in WO 2007/031796 that the payability and efficacy of a rodent bait is increased by the presentation to the rodent of a mixture of a plurality of bait particles (i.e. particles containing rodenticide) with a plurality of non-bait particles (particles not containing rodenticide) wherein the non-bait particles have a flavour different from the flavour of the bait particles and wherein the non-bait particles are distinguished from the bait particles by at least one physical characteristic selected from size, shape, surface texture and internal texture.
  • This concept may be utilised in the bait block of the present invention.
  • the bait block contains a plurality of bait particles, such as seed or cereal, treated with a rodenticide and a plurality of no n- bait particles, such as seed or cereal, which do not contain rodenticide, wherein the non-bait particles have a flavour different from the flavour of the bait particles and wherein the non-bait particles are distinguished from the bait particles by at least one physical characteristic selected from size, shape, surface texture and internal texture.
  • Particulate rodent bait comprising such a mixture of bait and non-bait particles is available under the name "FortecTM" from BASF pic.
  • the foodstuff comprising seed and/or cereal is bound together by a polymeric binder.
  • the polymeric binder used in the present invention comprises a copolymer based on an acrylic ester and acrylonitrile.
  • the polymeric binder comprises a copolymer based on an acrylic ester, acrylonitrile and (meth)acrylic acid.
  • the polymeric binder comprises at least 50% by weight of the acrylic ester component, preferably at least 70% and more preferably at least 80% by weight.
  • the acrylonitrile component of the copolymer of the polymeric binder is typically present in an amount not greater than 40% by weight, preferably up to and including 20% and more preferably not greater than 15% by weight.
  • the copolymer of the polymeric binder may also comprise (meth)acrylic acid.
  • (meth)acrylic acid we mean acrylic acid, methacrylic acid and mixtures thereof.
  • the (meth)acrylic acid component of the copolymer is typically present in the copolymer in an amount of not greater than 20% by weight, preferably not greater than 10% and more preferably not greater than 5% by weight.
  • the acrylic ester component is preferably a 1 to 12C alkyl ester of acrylic ester, more preferably a 1 to 6C alkyl ester.
  • the acrylic ester component of the copolymer described above is n -butyl acrylate.
  • the polymeric binder described above, is present in an amount of from 1 to 18% by weight based on the total weight of the bait block, preferably from 1 to 15% and more preferably 1 to 10% by weight. Since, as mentioned above, good hardness and high stability of the bait blocks of the present invention can be achieved using only a low content of polymeric binder, the polymeric binder is present, according to a particularly preferred embodiment of the invention, in an amount of 1 to 5% by weight based on the total weight of the bait block, especially 1 .5 to 4% and more especially 1 .5 to 3.5% by weight.
  • the bait block may also contain one or more components such as sweetening agents (e.g. sugar), vegetable oil, additional food components, pigments or dyes, flavouring agents, preservatives, taste deterrent (e.g. denatonium benzoate) and release agent (e.g. magnesium stearate).
  • sweetening agents e.g. sugar
  • vegetable oil additional food components
  • pigments or dyes e.g
  • the, or part of the, seed or cereal may be pre-treated with the rodenticidally-active substance before being mixed with the aqueous dispersion of the polymeric binder and any other components.
  • the polymeric binder as described above, is added in the manufacturing process in the form of an aqueous dispersion.
  • the aqueous dispersion will have a polymeric binder content (i.e. solids content) in the range of from 50 to 80% by weight, preferably 55 to 70%, more preferably 60 to 65% and most preferably 61 to 63% by weight and a pH in the range of from 5.5 to 6.5.
  • the aqueous dispersion is typically added in an amount such that final block contains 1 to 8%, preferably 1 to 15%, more preferably 1 to 10%, even more preferably 1 to 5%, especially 1 .5 to 4% and more especially 1.5 to 3.5% by weight of polymeric binder based on the total weight of the bait block.
  • final block contains 1 to 8%, preferably 1 to 15%, more preferably 1 to 10%, even more preferably 1 to 5%, especially 1 .5 to 4% and more especially 1.5 to 3.5% by weight of polymeric binder based on the total weight of the bait block.
  • we have found that good results are obtained by the use of 3% by weight (based on the total weight of the formulation) of an aqueous dispersion containing 63% by weight of polymeric binder.
  • the actual amount of polymeric binder is less than 2% by weight based on the total weight of the formulation.
  • the aqueous dispersion of the polymeric binder may be mixed with the other components of the bait block formulation in an industrial mixer or blender to ensure that the binder dispersion is distributed homogenously throughout the mixture.
  • Mixers or blenders of this type that may be used in the invention are well known to the person skilled in the art.
  • the mixture when formed, may be fed to moulds of the desired dimensions or extruded and cut into blocks.
  • the moulded, shaped or formed blocks will then be subjected to drying conditions to remove excess moisture.
  • the drying stage may be carried out at room temperature or may be assisted by the application of heat, if desired.
  • the present invention further provides a method for controlling rodents which comprises placing a rodenticidal bait block according to any one of claims 1 to 11 in the vicinity of rodent activity.
  • a wax-free rodenticidal bait block was made using the formulation shown in the table below.
  • the binder aqueous dispersion is an aqueous dispersion containing 62% by weight of polymer composition comprising 87 wt% n-butyl acrylate, 10 wt% acrylonitrile and 3 wt% acrylic acid, having pH of about 6.
  • the formulation above was mixed thoroughly and then compacted into a prepared mould. The moulded mixture was then removed from the mould and subjected to drying. The bait block, thus produced, possessed integrity and did not crumble or break easily.

Abstract

L'invention concerne un bloc d'appât rodenticide qui comprend une denrée alimentaire pour le rongeur comprenant une graine et/ou une céréale comestible, au moins un rodenticide et un liant polymère, le liant polymère comprenant un polymère à base d'un ester acrylique et de l'acrylonitrile et étant présent en une quantité comprise entre 1 et 18 % en poids, de préférence entre 1 et 10 %, et de préférence encore entre 1 et 5 % en poids, par rapport au poids total du bloc d'appât. Le bloc d'appât ne contient pas de cire et les liants polymères préférés utiles dans la présente invention comprennent un polymère à base d'un acrylate d'alkyle, de l'acrylonitrile et un acide (méth)acrylique. Les blocs d'appât selon l'invention ont un goût très agréable pour les rongeurs, en particulier les rats, présentent une dureté adéquate et une haute stabilité malgré l'utilisation d'une faible teneur en liant polymère.
PCT/EP2013/072442 2012-10-26 2013-10-25 Bloc d'appât rodenticide sans cire WO2014064272A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12190281 2012-10-26
EP12190281.1 2012-10-26
US201361759838P 2013-02-01 2013-02-01
US61/759,838 2013-02-01

Publications (1)

Publication Number Publication Date
WO2014064272A1 true WO2014064272A1 (fr) 2014-05-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/072442 WO2014064272A1 (fr) 2012-10-26 2013-10-25 Bloc d'appât rodenticide sans cire

Country Status (2)

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AR (1) AR093167A1 (fr)
WO (1) WO2014064272A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9700039B2 (en) 2013-03-27 2017-07-11 BASF Agro B.V. Rodenticidal soft bait composition
US9809364B2 (en) 2013-05-02 2017-11-07 BASF Agro B.V. Packaged rodenticidal bait
ITUA20164617A1 (it) * 2016-06-23 2017-12-23 Dr Tezza S R L Nuove composizioni rodenticide agglomerate
EP4070658A1 (fr) 2021-04-06 2022-10-12 BIORoxx GmbH Utilisation de composés anticoagulants comme rodenticides
US11678659B2 (en) 2014-06-11 2023-06-20 Dietrich Gulba Use as rodenticides of compounds that inhibit blood coagulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2115698A (en) 1982-02-26 1983-09-14 Ciba Geigy Ag Rodenticidal bait
WO1996003037A1 (fr) 1994-07-28 1996-02-08 Zeneca Limited Appat rodenticide
US20050048095A1 (en) 2001-10-04 2005-03-03 Juergen Friedel Pesticide and method for the production thereof
WO2007031796A2 (fr) 2005-09-15 2007-03-22 Sorex Limited Lutte contre les rongeurs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2115698A (en) 1982-02-26 1983-09-14 Ciba Geigy Ag Rodenticidal bait
WO1996003037A1 (fr) 1994-07-28 1996-02-08 Zeneca Limited Appat rodenticide
US20050048095A1 (en) 2001-10-04 2005-03-03 Juergen Friedel Pesticide and method for the production thereof
WO2007031796A2 (fr) 2005-09-15 2007-03-22 Sorex Limited Lutte contre les rongeurs

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9700039B2 (en) 2013-03-27 2017-07-11 BASF Agro B.V. Rodenticidal soft bait composition
US9809364B2 (en) 2013-05-02 2017-11-07 BASF Agro B.V. Packaged rodenticidal bait
US11678659B2 (en) 2014-06-11 2023-06-20 Dietrich Gulba Use as rodenticides of compounds that inhibit blood coagulation
ITUA20164617A1 (it) * 2016-06-23 2017-12-23 Dr Tezza S R L Nuove composizioni rodenticide agglomerate
EP3259988A1 (fr) * 2016-06-23 2017-12-27 Dr Tezza S.R.L. Nouvelles compositions d'agglomérats rodenticides
EP4070658A1 (fr) 2021-04-06 2022-10-12 BIORoxx GmbH Utilisation de composés anticoagulants comme rodenticides
WO2022214485A1 (fr) 2021-04-06 2022-10-13 Bioroxx Gmbh Utilisation de composés inhibiteurs de coagulation sanguine comme rodenticides

Also Published As

Publication number Publication date
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