WO2014002114A3 - Process for preparation of saxagliptin and hydrates thereof - Google Patents

Process for preparation of saxagliptin and hydrates thereof Download PDF

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Publication number
WO2014002114A3
WO2014002114A3 PCT/IN2013/000375 IN2013000375W WO2014002114A3 WO 2014002114 A3 WO2014002114 A3 WO 2014002114A3 IN 2013000375 W IN2013000375 W IN 2013000375W WO 2014002114 A3 WO2014002114 A3 WO 2014002114A3
Authority
WO
WIPO (PCT)
Prior art keywords
saxagliptin
preparation
hydrates
monohydrate
imolar
Prior art date
Application number
PCT/IN2013/000375
Other languages
French (fr)
Other versions
WO2014002114A2 (en
Inventor
Shekhar Bhaskar Bhirud
Kumar Hari Bhushan
Hiremath Veerabhadra Swamy
Dilipkumar Jibhau PATIL
Original Assignee
Glenmark Pharmaceuticals Limited; Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Limited; Glenmark Generics Limited filed Critical Glenmark Pharmaceuticals Limited; Glenmark Generics Limited
Publication of WO2014002114A2 publication Critical patent/WO2014002114A2/en
Publication of WO2014002114A3 publication Critical patent/WO2014002114A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Abstract

A process for the preparation of saxagliptin monohydrate is provided, comprising: a) reacting saxagliptin salt, b) adding more than 4 Imolar equivalent of water, and c) isolating saxagliptin monohydrate.
PCT/IN2013/000375 2012-06-29 2013-06-17 Process for the preparation of saxagliptin and hydrates thereof WO2014002114A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN1883MU2012 2012-06-29
IN1883/MUM/2012 2012-06-29
IN2232/MUM/2012 2012-08-02
IN2232MU2012 2012-08-02
US201261702857P 2012-09-19 2012-09-19
US61/702,857 2012-09-19

Publications (2)

Publication Number Publication Date
WO2014002114A2 WO2014002114A2 (en) 2014-01-03
WO2014002114A3 true WO2014002114A3 (en) 2014-02-20

Family

ID=49783963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000375 WO2014002114A2 (en) 2012-06-29 2013-06-17 Process for the preparation of saxagliptin and hydrates thereof

Country Status (1)

Country Link
WO (1) WO2014002114A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013175297A1 (en) 2012-05-24 2013-11-28 Apotex Pharmachem India Pvt. Ltd Salts of saxagliptin with organic acids
CN110940757B (en) * 2019-12-21 2022-07-29 尚科生物医药（上海）有限公司 High performance liquid chromatography detection method for saxagliptin intermediate and isomer thereof
CN114113419A (en) * 2020-08-26 2022-03-01 尚科生物医药（上海）有限公司 Chromatographic separation method of saxagliptin and isomer thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131149A2 (en) * 2007-04-20 2008-10-30 Bristol-Myers Squibb Company Crystal forms of saxagliptin and processes for preparing same
WO2012017028A1 (en) * 2010-08-06 2012-02-09 Sandoz Ag A novel crystalline compound comprising saxagliptin and phosphoric acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131149A2 (en) * 2007-04-20 2008-10-30 Bristol-Myers Squibb Company Crystal forms of saxagliptin and processes for preparing same
WO2012017028A1 (en) * 2010-08-06 2012-02-09 Sandoz Ag A novel crystalline compound comprising saxagliptin and phosphoric acid

Also Published As

Publication number Publication date
WO2014002114A2 (en) 2014-01-03

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