WO2013151577A8 - Interrogatory cell-based assays and uses thereof - Google Patents

Interrogatory cell-based assays and uses thereof Download PDF

Info

Publication number
WO2013151577A8
WO2013151577A8 PCT/US2012/054321 US2012054321W WO2013151577A8 WO 2013151577 A8 WO2013151577 A8 WO 2013151577A8 US 2012054321 W US2012054321 W US 2012054321W WO 2013151577 A8 WO2013151577 A8 WO 2013151577A8
Authority
WO
WIPO (PCT)
Prior art keywords
based assays
interrogatory
cell
interrogatory cell
cancer
Prior art date
Application number
PCT/US2012/054321
Other languages
French (fr)
Other versions
WO2013151577A1 (en
WO2013151577A9 (en
Inventor
Niven Rajin Narain
Rangaprasad Sarangarajan
Vivek K. VISHNUDAS
Min DU
Tony WALSHE
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020147030700A priority Critical patent/KR102149070B1/en
Priority to EP12873625.3A priority patent/EP2834366B1/en
Priority to CA2869296A priority patent/CA2869296A1/en
Priority to CN201711192165.3A priority patent/CN108048521B/en
Priority to AU2012376214A priority patent/AU2012376214B2/en
Priority to KR1020207023974A priority patent/KR20200105524A/en
Priority to CN201280073683.2A priority patent/CN104520435A/en
Application filed by Berg Llc filed Critical Berg Llc
Priority to JP2015503185A priority patent/JP6189926B2/en
Priority to NZ700647A priority patent/NZ700647B2/en
Priority to SG11201406201YA priority patent/SG11201406201YA/en
Priority to BR112014024537A priority patent/BR112014024537A2/en
Priority to EA201491833A priority patent/EA038600B1/en
Priority to MX2014011797A priority patent/MX357392B/en
Publication of WO2013151577A1 publication Critical patent/WO2013151577A1/en
Priority to IL234920A priority patent/IL234920B/en
Publication of WO2013151577A9 publication Critical patent/WO2013151577A9/en
Publication of WO2013151577A8 publication Critical patent/WO2013151577A8/en
Priority to HK15109778.2A priority patent/HK1209161A1/en
Priority to AU2019200670A priority patent/AU2019200670B2/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)

Abstract

Described herein is a discovery Platform Technology for analyzing a biological system or process (e.g., a disease condition, such as cancer) via model building.
PCT/US2012/054321 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof WO2013151577A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
MX2014011797A MX357392B (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof.
CA2869296A CA2869296A1 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
CN201711192165.3A CN108048521B (en) 2012-04-02 2012-09-07 Interrogative cell-based assays and uses thereof
AU2012376214A AU2012376214B2 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
KR1020207023974A KR20200105524A (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
CN201280073683.2A CN104520435A (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
SG11201406201YA SG11201406201YA (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
JP2015503185A JP6189926B2 (en) 2012-04-02 2012-09-07 Cell-based assays with matching and uses thereof
NZ700647A NZ700647B2 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
KR1020147030700A KR102149070B1 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
BR112014024537A BR112014024537A2 (en) 2012-04-02 2012-09-07 methods to identify modulators of a biological system, a disease process, and angiogenesis
EA201491833A EA038600B1 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
EP12873625.3A EP2834366B1 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof
IL234920A IL234920B (en) 2012-04-02 2014-10-01 Interrogatory cell-based assays and uses thereof
HK15109778.2A HK1209161A1 (en) 2012-04-02 2015-10-07 Interrogatory cell-based assays and uses thereof
AU2019200670A AU2019200670B2 (en) 2012-04-02 2019-01-31 Interrogatory cell-based assays and uses thereof

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201261619326P 2012-04-02 2012-04-02
US61/619,326 2012-04-02
US201261620305P 2012-04-04 2012-04-04
US61/620,305 2012-04-04
US201261665631P 2012-06-28 2012-06-28
US61/665,631 2012-06-28
US201261668617P 2012-07-06 2012-07-06
US61/668,617 2012-07-06
US201261678596P 2012-08-01 2012-08-01
US201261678590P 2012-08-01 2012-08-01
US61/678,596 2012-08-01
US61/678,590 2012-08-01

Publications (3)

Publication Number Publication Date
WO2013151577A1 WO2013151577A1 (en) 2013-10-10
WO2013151577A9 WO2013151577A9 (en) 2014-11-20
WO2013151577A8 true WO2013151577A8 (en) 2014-12-31

Family

ID=49235335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/054321 WO2013151577A1 (en) 2012-04-02 2012-09-07 Interrogatory cell-based assays and uses thereof

Country Status (14)

Country Link
US (2) US10061887B2 (en)
EP (1) EP2834366B1 (en)
JP (3) JP6189926B2 (en)
KR (2) KR20200105524A (en)
CN (3) CN104520435A (en)
AU (2) AU2012376214B2 (en)
BR (1) BR112014024537A2 (en)
CA (1) CA2869296A1 (en)
EA (1) EA038600B1 (en)
HK (1) HK1209161A1 (en)
IL (1) IL234920B (en)
MX (1) MX357392B (en)
SG (2) SG10201608234UA (en)
WO (1) WO2013151577A1 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107273712B (en) 2011-03-02 2021-12-03 博格有限责任公司 Interrogative cell-based assays and uses thereof
EP2668945A1 (en) * 2012-06-01 2013-12-04 Bayer Technology Services GmbH Genotype and phenotype-based medicinal formulations
US9449284B2 (en) * 2012-10-04 2016-09-20 Nec Corporation Methods and systems for dependency network analysis using a multitask learning graphical lasso objective function
CN103558354B (en) * 2013-11-15 2015-07-15 南京大学 Water toxicity analysis method based on biologic omics integrated technology
WO2015196080A1 (en) * 2014-06-20 2015-12-23 Connecticut Children's Medical Center Automated cell culture system and corresponding methods
EP3191975A4 (en) 2014-09-11 2018-04-18 Berg LLC Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
CN105624275B (en) * 2014-11-06 2020-03-27 上海市东方医院 Application of EIF4G1 in diagnosis and treatment of squamous cell carcinoma
JP6270221B2 (en) * 2015-02-13 2018-01-31 国立研究開発法人産業技術総合研究所 Biomarker search method, biomarker search device, and program
KR101786859B1 (en) * 2015-04-30 2017-10-17 서울대학교산학협력단 Method for monitoring clinical and pathological alzheimer's disease using amyloid beta concentration in plasma
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
US10351845B2 (en) * 2015-05-28 2019-07-16 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Assays to identify genetic elements affecting phenotype
CN106250717B (en) * 2015-06-04 2019-03-12 徐勇 The miRNA of acute myeloid leukaemia and the system of transcription factor and its construction method and application
US20160363567A1 (en) * 2015-06-15 2016-12-15 Lunatech, Llc Vapor Device For Stressing And Analyzing Compounds
WO2017065127A1 (en) * 2015-10-14 2017-04-20 公立大学法人横浜市立大学 Blood biomarker for use in evaluation of effect of drug therapy on kidney cancer
JP7075126B2 (en) 2016-06-10 2022-05-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Image-based cell sorting system and method
WO2018090054A1 (en) 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
CN106834105A (en) * 2017-02-21 2017-06-13 齐齐哈尔医学院 A kind of apparatus and method for epigenetic analysis
US11636917B2 (en) * 2017-06-28 2023-04-25 The Regents Of The University Of California Simulating the metabolic pathway dynamics of an organism
CN107475346B (en) * 2017-08-11 2021-08-06 北京汉典制药有限公司 Method for in vitro screening of diabetic nephropathy medicine
JP6902977B2 (en) * 2017-09-22 2021-07-14 新日本無線株式会社 How to detect a failure in the startup circuit
EP3697925A4 (en) * 2017-10-18 2021-06-23 Venn Biosciences Corporation Identification and use of biological parameters for diagnosis and treatment monitoring
JP2021073432A (en) * 2018-03-02 2021-05-13 国立研究開発法人医薬基盤・健康・栄養研究所 Screening method of activated kinase being therapeutic target
JP7176381B2 (en) * 2018-12-03 2022-11-22 富士通株式会社 Structure search method for cyclic molecule, structure search device, and program
CN109536473A (en) * 2018-12-19 2019-03-29 华中科技大学鄂州工业技术研究院 The method for integrating key protein matter kinases in multiple groups data-speculative cells transdifferentiate
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. Data compression and communication using machine learning
US20210080466A1 (en) * 2019-06-26 2021-03-18 Berg Llc Markers for the diagnosis of prostate cancer
CN115298702A (en) * 2020-03-10 2022-11-04 Ai:On创新公司 Systems and methods for mammalian transfer learning
US11227690B1 (en) * 2020-09-14 2022-01-18 Opendna Ltd. Machine learning prediction of therapy response
CN113035298B (en) * 2021-04-02 2023-06-20 南京信息工程大学 Drug clinical trial design method for recursively generating large-order line limiting coverage array
CN113138249B (en) * 2021-04-12 2021-11-23 北京蛋白质组研究中心 Micro-sample metabolome, proteome and phosphoproteome multi-group chemical analysis method based on micropore array chip
EP4338163A1 (en) * 2021-05-13 2024-03-20 Scipher Medicine Corporation Assessing responsiveness to therapy
CN113943720A (en) * 2021-11-03 2022-01-18 江苏省农业科学院 Apolygus lucorum GRK gene, dsRNA thereof, synthetic method and application thereof
WO2023230268A1 (en) * 2022-05-27 2023-11-30 Memorial Sloan-Kettering Cancer Center Systems and methods for metabolite imputation
CN117417914A (en) * 2022-07-18 2024-01-19 华东师范大学 Marker for preventing and protecting cerebral ischemia diseases and application of aspirin derivative in preventing and protecting cerebral ischemia diseases
WO2024081570A1 (en) * 2022-10-10 2024-04-18 Eli Lilly And Company Methods and systems for using causal networks to develop models for evaluating biological processes
WO2024081740A1 (en) * 2022-10-13 2024-04-18 Somalogic Operating Co., Inc. Systems and methods for validation of proteomic models

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
DE3689123T2 (en) 1985-11-01 1994-03-03 Xoma Corp MODULAR UNIT OF ANTIBODY GENES, ANTIBODIES MADE THEREOF AND USE.
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US6121424A (en) 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
DE768377T1 (en) 1988-09-02 1998-01-02 Dyax Corp Production and selection of recombinant proteins with different binding sites
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (en) 1990-07-10 2000-02-16 Medical Res Council PROCEDURES FOR THE PRODUCTION OF SPECIFIC UNION COUPLE MEMBERS.
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ES2108048T3 (en) 1990-08-29 1997-12-16 Genpharm Int PRODUCTION AND USE OF LOWER TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGICAL ANTIBODIES.
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech Inc METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
ES2315612T3 (en) 1991-04-10 2009-04-01 The Scripps Research Institute GENOTECAS OF HETERODYMERIC RECEPTORS USING PHAGEMIDS.
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
DE69233501T2 (en) 1991-11-22 2006-02-23 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Combinatorial strategies for polymer synthesis
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
ATE267877T1 (en) 1993-01-07 2004-06-15 Sequenom Inc DNA SEQUENCING THROUGH MASS SPECTRONOMY
EP0689610B1 (en) 1993-03-19 2002-07-03 Sequenom, Inc. Dna sequencing by mass spectrometry via exonuclease degradation
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc Nucleic acid analysis techniques
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6033860A (en) 1997-10-31 2000-03-07 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
WO2002072871A2 (en) 2001-03-13 2002-09-19 Ashni Naturaceuticals, Inc. Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes
US8000949B2 (en) * 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
ATE398808T1 (en) 2002-08-29 2008-07-15 Gene Network Sciences Inc SYSTEMS AND METHODS FOR INFERENCE ON BIOLOGICAL NETWORKS
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
JP4288345B2 (en) * 2003-06-19 2009-07-01 独立行政法人産業技術総合研究所 New epilepsy model animal
EP1512970A1 (en) 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
US20070134734A1 (en) 2003-10-14 2007-06-14 Cellfree Sciences Co., Ltd. Novel screening method of indicator substance
WO2005107412A2 (en) 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
EP1607898A3 (en) * 2004-05-18 2006-03-29 Neal E. Solomon A bioinformatics system for functional proteomics modelling
US20100316629A1 (en) 2004-09-01 2010-12-16 Shaughnessy Jr John D Use of gene expression profiling to predict survival in cancer patient
WO2006054991A1 (en) * 2004-11-17 2006-05-26 Immunivest Corporation Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection
EP1842147A2 (en) * 2005-01-24 2007-10-10 The Board of Trustees of The Leland Stanford Junior University Method for modeling cell signaling systems by means of bayesian networks
WO2006129401A1 (en) * 2005-05-31 2006-12-07 Jcl Bioassay Corporation Screening method for specific protein in proteome comprehensive analysis
US7906116B2 (en) * 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
CA2622852A1 (en) 2005-09-30 2007-04-12 Universiteit Maastricht Tumor angiogenesis associated genes and a method for their identification
US8571803B2 (en) * 2006-11-15 2013-10-29 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
JP2009050171A (en) * 2007-08-23 2009-03-12 Toyobo Co Ltd Method for detecting phosphorylation on substrate by surface plasmon resonance
CA2930393C (en) 2007-12-04 2022-11-29 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
UA104868C2 (en) * 2008-08-15 2014-03-25 Меррімак Фармасьютікалз, Інк. Method for treating patient having neoplastic tumor according to predicted reaction
EP2356258A4 (en) * 2008-11-17 2012-12-26 Veracyte Inc Methods and compositions of molecular profiling for disease diagnostics
EA201101522A1 (en) * 2009-05-11 2012-09-28 БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи METHODS OF TREATMENT OF DISEASES WITH THE USE OF EPIMETABOLIC SWITCH (COENZIM Q10)
US20130023574A1 (en) 2010-03-31 2013-01-24 National University Corporation Kumamoto University Method for generating data set for integrated proteomics, integrated proteomics method using data set for integrated proteomics that is generated by the generation method, and method for identifying causative substance using same
CN107273712B (en) 2011-03-02 2021-12-03 博格有限责任公司 Interrogative cell-based assays and uses thereof

Also Published As

Publication number Publication date
IL234920B (en) 2019-12-31
JP6767320B2 (en) 2020-10-14
AU2012376214A1 (en) 2014-10-30
EA201491833A1 (en) 2015-01-30
JP6189926B2 (en) 2017-08-30
NZ718138A (en) 2017-11-24
US10061887B2 (en) 2018-08-28
AU2019200670B2 (en) 2021-09-23
SG10201608234UA (en) 2016-11-29
NZ700647A (en) 2016-08-26
AU2012376214B2 (en) 2019-02-14
WO2013151577A1 (en) 2013-10-10
IL234920A0 (en) 2014-12-31
EP2834366B1 (en) 2024-05-29
AU2019200670A1 (en) 2019-02-21
KR102149070B1 (en) 2020-10-15
EP2834366A1 (en) 2015-02-11
SG11201406201YA (en) 2014-10-30
CN108048521A (en) 2018-05-18
CN110456035A (en) 2019-11-15
KR20200105524A (en) 2020-09-07
JP2021003121A (en) 2021-01-14
JP2018033448A (en) 2018-03-08
EP2834366A4 (en) 2016-04-27
US20190279736A1 (en) 2019-09-12
MX357392B (en) 2018-07-06
MX2014011797A (en) 2014-12-10
HK1209161A1 (en) 2016-03-24
EA038600B1 (en) 2021-09-21
BR112014024537A2 (en) 2017-08-08
US20130259847A1 (en) 2013-10-03
KR20140142357A (en) 2014-12-11
CN104520435A (en) 2015-04-15
WO2013151577A9 (en) 2014-11-20
CA2869296A1 (en) 2013-10-10
JP2015519876A (en) 2015-07-16
CN108048521B (en) 2022-05-27

Similar Documents

Publication Publication Date Title
WO2013151577A8 (en) Interrogatory cell-based assays and uses thereof
SG193006A1 (en) Interrogatory cell-based assays and uses thereof
WO2013176694A8 (en) Interrogatory cell-based assays for identifying drug-induced toxicity markers
WO2012047618A3 (en) Mesothelioma biomarkers and uses thereof
WO2013070756A3 (en) System and method for processing samples
WO2011120006A8 (en) Detection system for droplet-based assays
WO2012024658A3 (en) Integrated analysis system
GB201014805D0 (en) Microfluidics based assay device
EP2649447A4 (en) Sample analysis system
WO2014083435A3 (en) Handling liquid samples
BR112012006055A2 (en) methods for use in predicting sand production from a geomechanical reservoir system, for producing sand from a geomechanical reservoir system, and for operating a geomechanical reservoir system to control sand production from the geomechanical reservoir system
WO2013121342A3 (en) Lighting configuration apparatus and methods utilizing distance sensors
WO2014007308A3 (en) Positioning by a moving communication system
WO2014028378A3 (en) Methods and systems for detecting biological components
BR112015001592A8 (en) image analysis and measurements of biological samples
WO2012012725A3 (en) Methods of detecting diseases or conditions using phagocytic cells
WO2012015904A3 (en) Biomarkers for prostate cancer and methods using the same
WO2011100749A3 (en) Methods and materials for detecting viral or microbial infections
WO2009075554A3 (en) Patent information providing method and system
MY164162A (en) System validation
WO2012047941A3 (en) Hemagglutinin polypeptides, and reagents and methods relating thereto
BR112014032114A2 (en) biomass conversion system and method.
FR2964331B1 (en) CHEMICALLY STABILIZED MEMBRANE, PROCESS FOR PREPARING THE SAME AND USES THEREOF
EP2672270A4 (en) Specimen analysis system, specimen analysis device, and specimen analysis method
EP2476069A4 (en) Database searching method, system and controller

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12873625

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2015503185

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: MX/A/2014/011797

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2869296

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112014024537

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 2012873625

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2012376214

Country of ref document: AU

Date of ref document: 20120907

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20147030700

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 201491833

Country of ref document: EA

ENP Entry into the national phase

Ref document number: 112014024537

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20141001