WO2013048169A3 - Method for preparing taxane derivatives - Google Patents
Method for preparing taxane derivatives Download PDFInfo
- Publication number
- WO2013048169A3 WO2013048169A3 PCT/KR2012/007885 KR2012007885W WO2013048169A3 WO 2013048169 A3 WO2013048169 A3 WO 2013048169A3 KR 2012007885 W KR2012007885 W KR 2012007885W WO 2013048169 A3 WO2013048169 A3 WO 2013048169A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- docetaxel
- preparing
- taxane derivatives
- specific structure
- preparing taxane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
There is provided a method for preparing docetaxel that is a taxane derivative, and more specifically, a method for preparing docetaxel in which since the docetaxel having high purity can be prepared at a high yield through a simple production method including preparing an intermediate having a specific structure of a steric configuration that is the same type as the docetaxel that is a final product from a taxane compound having a specific structure and then semi-synthesizing the docetaxel using them, the method is very suitable for industrial manufacturing.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014533210A JP5870197B2 (en) | 2011-09-30 | 2012-09-28 | Method for producing taxane derivative |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110099780A KR101379694B1 (en) | 2011-09-30 | 2011-09-30 | Method for preparing taxane derivatives |
KR10-2011-0099780 | 2011-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013048169A2 WO2013048169A2 (en) | 2013-04-04 |
WO2013048169A3 true WO2013048169A3 (en) | 2013-06-13 |
Family
ID=47996638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2012/007885 WO2013048169A2 (en) | 2011-09-30 | 2012-09-28 | Method for preparing taxane derivatives |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP5870197B2 (en) |
KR (1) | KR101379694B1 (en) |
WO (1) | WO2013048169A2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100255460B1 (en) * | 1992-10-30 | 2000-05-01 | 자끄 사비나 | Method for preparing taxane derivatives |
KR100297197B1 (en) * | 1992-10-05 | 2001-11-26 | 자끄 사비나 | Manufacturing method of taxane derivative |
US20040073044A1 (en) * | 2002-05-10 | 2004-04-15 | Sharma Arun Prakash | Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof |
KR20080054986A (en) * | 2006-12-14 | 2008-06-19 | 한미약품 주식회사 | Method of preparing docetaxel and intermediates used therein |
-
2011
- 2011-09-30 KR KR1020110099780A patent/KR101379694B1/en active IP Right Grant
-
2012
- 2012-09-28 WO PCT/KR2012/007885 patent/WO2013048169A2/en active Application Filing
- 2012-09-28 JP JP2014533210A patent/JP5870197B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100297197B1 (en) * | 1992-10-05 | 2001-11-26 | 자끄 사비나 | Manufacturing method of taxane derivative |
KR100255460B1 (en) * | 1992-10-30 | 2000-05-01 | 자끄 사비나 | Method for preparing taxane derivatives |
US20040073044A1 (en) * | 2002-05-10 | 2004-04-15 | Sharma Arun Prakash | Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof |
KR20080054986A (en) * | 2006-12-14 | 2008-06-19 | 한미약품 주식회사 | Method of preparing docetaxel and intermediates used therein |
Non-Patent Citations (1)
Title |
---|
QI, C. M. ET AL.: "A novel method to synthesize docetaxel and its isomer with high yields.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 42, no. 4, 2005, pages 679 - 684, XP002482597 * |
Also Published As
Publication number | Publication date |
---|---|
JP5870197B2 (en) | 2016-02-24 |
JP2014528408A (en) | 2014-10-27 |
KR101379694B1 (en) | 2014-03-31 |
WO2013048169A2 (en) | 2013-04-04 |
KR20130035466A (en) | 2013-04-09 |
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