WO2012035492A1 - Robotic control of an endoscope from blood vessel tree images - Google Patents
Robotic control of an endoscope from blood vessel tree images Download PDFInfo
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- WO2012035492A1 WO2012035492A1 PCT/IB2011/053998 IB2011053998W WO2012035492A1 WO 2012035492 A1 WO2012035492 A1 WO 2012035492A1 IB 2011053998 W IB2011053998 W IB 2011053998W WO 2012035492 A1 WO2012035492 A1 WO 2012035492A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00147—Holding or positioning arrangements
- A61B1/00149—Holding or positioning arrangements using articulated arms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
- A61B1/00006—Operational features of endoscopes characterised by electronic signal processing of control signals
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00043—Operational features of endoscopes provided with output arrangements
- A61B1/00045—Display arrangement
- A61B1/0005—Display arrangement combining images e.g. side-by-side, superimposed or tiled
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/313—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
- A61B1/3137—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes for examination of the interior of blood vessels
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- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
- A61B2017/00252—Making holes in the wall of the heart, e.g. laser Myocardial revascularization for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
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- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
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- G06T2207/30004—Biomedical image processing
- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
Definitions
- the present invention generally relates to robotic control of an endoscope during a minimally invasive surgical procedure (e.g., a minimally invasive coronary bypass grafting surgery).
- the present invention specifically relates to a matching of a graphical representation of a pre-operative three-dimensional ("3D") blood vessel tree image to a graphical representation of an intra-operative endoscopic blood vessel tree image as a basis for robotic guiding of an endoscope.
- 3D three-dimensional
- Coronary artery bypass grafting (“CABG”) is a surgical procedure for CABG.
- minimally invasive CABG In minimally invasive CABG, the aforementioned problem of conventional CABG is amplified because a surgeon cannot palpate the heart surface. Additionally, the length of surgical instruments used in minimally invasive CABG prevents any tactile feedback from the proximal end of the tool.
- One known technique for addressing the problems with conventional CABG is to register an intra-operative site with a pre-operative 3D coronary artery tree.
- an optically tracked pointer is used to digitalize position of the arteries in an open heart setting and the position data is registered to pre-operative tree using an Iterative Closest Point ("ICP") algorithm known in art.
- ICP Iterative Closest Point
- this technique as with any related approach matching digitized arteries and pre-operative data, is impractical for minimally invasive CABG because of spatial constraints imposed by a small port access. Also, this technique requires most of the arteries to be either visible or palpated by the surgeon, which is impossible in minimally invasive CABG.
- One known technique for addressing the problems with minimally invasive CABG is to implement a registration method in which the heart surface is reconstructed using an optically tracked endoscope and matched to pre-operative computer tomography ("CT") data of the same surface.
- CT computer tomography
- this technique may fail if the endoscope view used to derive the surface is too small.
- the algorithm of this technique more often than not operates in a suboptimal local maximum of the algorithm.
- Another known technique for addressing the problems with minimally invasive CABG is to label a coronary tree extracted from a new patient using a database of previously labeled cases and graph based matching.
- this technique works only if a complete tree is available and it's goal is to label the tree rather to match the geometry.
- a further problem of minimally invasive CABG is an orientation and a guidance of the endoscope once the global positioning with respect to pre-operative 3D images is reached.
- the goal of registration is to facilitate localization of the anastomosis site and the stenosis.
- the endoscope In a standard setup, the endoscope is being held by an assistant, while the surgeon holds two instruments. The surgeon issues commands to the assistant and the assistant moves the endoscope accordingly.
- This kind of setup hinders hand-eye coordination of the surgeon, because the assistant needs to intuitively translate surgeon's commands, typically issued in the surgeon's frame of reference, to the assistant's frame of reference and the endoscope's frame of reference.
- Plurality of coordinate systems may cause various handling errors, prolong the surgery or cause misidentification of the coronary arteries.
- a surgical endoscope assistant designed to allow a surgeon to directly control an endoscope via a sensed movement of the surgeon head may solve some of those problems by removing the assistant from the control loop, but the problem of transformation between the surgeon's frame of reference and the endoscope's frame of reference remains.
- the present invention provides methods for matching graphical representations of a blood vessel tree (e.g., furcation of arteries, capillaries or veins) as shown in a pre-operative three-dimensional (“3D") image (e.g., a CT image, a cone beam CT image, a 3D X-Ray images or a MRI image) and in an intra-operative endoscopic image, overlaying the blood vessel tree from the pre-operative 3D image to the intra-operative endoscopic image, and using the overlay to guide a robot holding an endoscope toward a location as defined in the pre-operative 3D image.
- 3D three-dimensional
- One form of the present invention is a robotic guiding system employing a robot unit and a control unit.
- a robot guiding system employs a robot unit and a control unit.
- the robot unit includes an endoscope for generating an intra-operative endoscopic image of a blood vessel tree within an anatomical region, and a robot for moving the endoscope within the anatomical region.
- the control unit includes an endoscope controller for generating an endoscopic path within the anatomical region, wherein the endoscopic path is derived from a matching of a graphical representation of the intra-operative endoscopic image of the blood vessel tree to a graphical representation of a pre-operative three-dimensional image of the blood vessel tree.
- the control unit further includes a robot controller for commanding the robot to move the endoscope within the anatomical region in accordance with the endoscopic path.
- a second form of the present invention is a robot guiding method involving a generation of an intra-operative endoscopic image of a blood vessel tree within an anatomical region and a generation of an endoscopic path within the anatomical region, wherein the endoscopic path is derived from a matching of a graphical representation of the intra- operative endoscopic image of the blood vessel tree to a graphical representation of a preoperative three-dimensional image of the blood vessel tree.
- the robot guiding method further involves a commanding of a robot to move an endoscope within the anatomical region in accordance with the endoscopic path.
- pre-operative as used herein is broadly defined to describe any activity executed before, during or after an endoscopic imaging of an anatomical region for purposes of acquiring a three-dimensional image of the anatomical region
- intraoperative as used herein is broadly defined to describe any activity executed by the robot unit and the control unit during an endoscopic imaging of the anatomical region.
- Examples of an endoscopic imaging of an anatomical region include, but are not limited to, a CABG, a bronchoscopy, a colonscopy, a laparascopy, and a brain endoscopy.
- FIG. 1 illustrates an exemplary embodiment of a robotic guiding system in
- FIG. 2 illustrates a flowchart representative of an exemplary embodiment of a robotic guidance method in accordance with the present invention.
- FIG. 3 illustrates an exemplary surgical implementation of the flowchart shown in
- FIG. 4 illustrates a flowchart representative of an exemplary embodiment of a graph matching method in accordance with the present invention.
- FIGS. 5 and 6 illustrate an exemplary ordering of main graphs of a blood vessel tree in accordance with the present invention.
- FIG. 7 illustrates an exemplary overlay of geometrical representation on an endoscopic image accordance with the present invention.
- FIG. 8 illustrates an exemplary robot paths within the overlay shown in FIG. 7 in accordance with the present invention.
- a robotic guiding system employs a robot unit 10 and a control unit 20 for any endoscopic procedure involving an endoscopic imaging of a blood vessel tree having one or more furcations (i.e., branches).
- endoscopic procedures include, but are not limited to, minimally invasive cardiac surgery (e.g., coronary artery bypass grafting or mitral valve replacement).
- Robot unit 10 includes a robot 1 1, an endoscope 12 rigidly attached to robot 11 and a video capture device 13 attached to the endoscope 12.
- Robot 11 is broadly defined herein as any robotic device structurally configured with motorized control of one or more joints for maneuvering an end-effector as desired for the particular endoscopic procedure.
- robot 11 may have four (4) degrees-of- freedom, such as, for example, a serial robot having joints serially connected with rigid segments, a parallel robot having joints and rigid segments mounted in parallel order (e.g., a Stewart platform known in the art) or any hybrid combination of serial and parallel kinematics.
- Endoscope 12 is broadly defined herein as any device structurally configured with ability to image from inside a body.
- Examples of endoscope 12 for purposes of the present invention include, but are not limited to, any type of scope, flexible or rigid (e.g., endoscope, arthroscope, bronchoscope, choledochoscope, colonoscope, cystoscope, duodenoscope, gastroscope, hysteroscope, laparoscope, laryngoscope, neuroscope, otoscope, push enteroscope, rhino laryngoscope, sigmoidoscope, sinuscope, thorascope, etc.) and any device similar to a scope that is equipped with an image system (e.g., a nested cannula with imaging).
- the imaging is local, and surface images may be obtained optically with fiber optics, lenses, and miniaturized (e.g. CCD based) imaging systems.
- endoscope 12 is mounted to the end-effector of robot 11.
- a pose of the end-effector of robot 11 is a position and an orientation of the end-effector within a coordinate system of robot 11 actuators.
- any given pose of the field-of-view of endoscope 12 within an anatomical region corresponds to a distinct pose of the end-effector of robot 11 within the robotic coordinate system. Consequently, each individual endoscopic image of a blood vessel tree generated by endoscope 12 may be linked to a corresponding pose of endoscope 12 within the anatomical region.
- Video capture device 13 is broadly defined herein as any device structurally configured with a capability to convert an intra-operative endoscopic video signal from endoscope 12 into a computer readable temporal sequence of intra-operative endoscopic image ("IOEI") 14.
- video capture device 13 may employ a frame grabber of any type for capturing individual digital still frames from the intra-operative endoscopic video signal.
- control unit 20 includes a robot controller 21 and an endoscope controller 22.
- Robot controller 21 is broadly defined herein as any controller structurally configured to provide one or more robot actuator commands (“RAC”) 26 to robot 11 for controlling a pose of the end-effector of robot 11 as desired for the endoscopic procedure. More particularly, robot controller 21 converts endoscope position commands (“EPC") 25 from endoscope controller 22 into robot actuator commands 26.
- EPC endoscope position commands
- endoscope position commands 25 may indicate an endoscopic path leading to desired 3D position of a field-of- view of endoscope 12 within an anatomical region whereby robot controller 21 converts command 25 into commands 26 including an actuation current for each motor of robot 11 as needed to move endoscope 12 to the desired 3D position.
- Endoscope controller 22 is broadly defined herein as any controller structurally configured for implementing a robotic guidance method in accordance with the present invention and exemplary shown in FIG. 2.
- endoscope controller 22 may incorporate an image processing module ("IPM") 23, which is broadly defined herein as any module structurally configured for executing an anatomical object image registration of the present invention.
- IPM image processing module
- Endoscope controller 22 may further incorporate a visual servo module ("VSM”) 24, which is broadly defined herein as any module structurally configured for generating endoscope position commands 25 indicating an endoscopic path leading to desired 3D position of a field-of-view of endoscope 12 within an anatomical region.
- VSM visual servo module
- endoscope position commands 25 are derived from the blood vessel tree image registration as exemplarily implemented by a stage S34 of flowchart 30 shown in FIG. 2.
- a stage S31 of flowchart 30 encompasses an extraction of a geometrical representation of a blood vessel tree from a pre-operative 3D image.
- a 3D imaging device e.g., a CT device, an X-ray device, or a MRI device
- a blood vessel tree extractor 43 is operated to extract a geometrical representation 44 of a coronary arterial tree from image 42, which may be stored in a database 45.
- a Brilliance iCT scanner sold by Philips may be used to generate image 42 and to extract a 3D dataset of the coronary arterial tree from image 42.
- a stage S32 of flowchart 30 encompasses image processing module 23 matching the graphical representation of one or more intra-operative endoscopic images 14 (FIG. 1) of the blood vessel tree to a graphical representation of pre-operative 3D image 44 (FIG. 1) of the blood vessel tree.
- endoscope 12 generates an intra-operative endoscopy video of a chest region of patient 50 that is captured by video capture device 13 and converted into intra-operative endoscopic images 14 whereby image processing module 23 of endoscope controller 22 matches a graphical representation of the intra-operative endoscopic image(s) 14 of the coronary arterial tree to a graphical representation of pre-operative 3D image 44 of the coronary arterial tree.
- image processing module 23 executes a blood vessel tree image matching method of the present invention as exemplarily represented by a flowchart 60 shown in FIG. 4, which will be described herein in the context of the blood vessel tree being a coronary arterial tree.
- a stage S61 of flowchart 60 encompasses image processing module 23 generating a coronary arterial tree main graph from a geometrical representation of the coronary arterial tree in accordance with any representation method known in the art.
- a geometrical representation 70 of a coronary arterial tree is converted into a main graph 71 having nodes represented of each furcation (e.g., a bifurcation or trifurcation) of coronary arterial tree geometrical representation 70 and further having branch connections between nodes.
- Stage S61 may be performed pre-operatively (e.g., days before the endoscopic surgery or any time prior to an introduction of endoscope 12 within patient 50), or intra-operatively by means of a C-arm angiography or other suitable system.
- a stage S62 of flowchart 60 encompasses image processing module 23 generating a coronary arterial tree subgraph from a portion of a coronary arterial tree visible in an intra- operative endoscopic image 14 in accordance with any graphical representation method known in the art.
- endoscope 12 is introduced into patient 50 whereby image processing module 23 performs a detection of a coronary arterial structure within the intraoperative endoscopic image 14.
- some arterial structures may be visible while other arterial structures may be hidden by a layer of fatty tissue.
- image processing module 23 may implement an automatic detection of visible coronary arterial structure(s) by known image processing operations (e.g., threshold detection by the distinct red color of the visible coronary arterial structure(s)), or a surgeon may manually use an input device to outline the visible coronary arterial structure(s) on the computer display.
- image processing module 23 Upon a detection of the arterial structure(s), image processing module 23 generates the coronary arterial tree graph in a similar manner to the generation of the coronary arterial tree main graph.
- a geometrical representation 72 of coronary arterial structure(s) is converted into a graph 73 having nodes represented of each furcation (e.g., a bifurcation or trifurcation) of coronary arterial tree geometrical representation 72 and further having branch connections between nodes. Since both trees are coming from the same person, it is understood that the graph derived from endoscopy images is a subgraph of the graph derived from 3D images.
- a stage S63 of flowchart 60 encompasses image processing module 23 matching the subgraph to the maingraph in accordance with any known graph matching methods (e.g., maximum common subgraph or McGregor common subgraph). For example, as shown in stage S63, the nodes of subgraph 73 are matched to a subset of nodes of main graph 71.
- any known graph matching methods e.g., maximum common subgraph or McGregor common subgraph.
- subgraph 73 may only be partially detected within intra-operative endoscopic image 14 or some nodes/connections of subgraph 73 may be missing from intraoperative endoscopic image 14. To improve upon the matching accuracy of stage S62, an additional ordering of main graph 71 and subgraph 73 may be implemented.
- a vertical node ordering of main graph 71 is implemented based on a known orientation of patient 50 during the image scanning of stage S61.
- the main graph nodes may be directionally linked to preserve a top-bottom order as exemplarily shown in FIG. 5 via the solid arrows.
- the orientation of patient 50 relative to endoscope 12 may not be known. However, knowing that branches of the coronary arterial tree reduce in diameter as they expand top-bottom, then varying arterial sizes of the arterial branches in intra-operative endoscopic image 14 may indicate orientation.
- a horizontal node ordering of main graph 70 may be implemented based on the known orientation of patient 50 during the image scanning of stage S61. Specifically, the main graph nodes may be directionally linked to preserve a left-right node order as exemplarily shown in FIG. 6 via the dashed arrows. For subgraph 73, with the orientation of patient 50 to endoscope 12 more than likely being unknown, the horizontal node order of subgraph 73 may be set by the operating surgeon or an assistant via a graphical user interface.
- a stage S33 of flowchart encompasses an overlay of the geometrical representation of pre-operative 3D image 44 (FIG. 1) of the blood vessel tree on the intra-operative endoscopic image 14 of the blood vessel tree. This is done by using the geometrical representation uniquely associated to the maingraph.
- the entire geometry may be directly translated to intra-operative endoscopic image 14 using a perspective transformation.
- the perspective transformation may be detected from intra-operative endoscopic image 14 and nodes in pre-operative 3D image 44 using matching algorithms known in art, such as, of example, homography matching.
- FIG. 7 illustrates a geometrical representation 80 of a coronary arterial tree having nodes matched to nodes 91-95 with an intra-operative endoscopic image 90.
- the distance between each node pair among nodes 91-95 may be used to determine a scaling factor for geometrical representation 80 to thereby enable geometrical representation 80 to overlay intra-operative endoscopic image 90 as shown.
- stage S32 (FIG. 2) yields multiple results, then all possible overlays may be displayed to the surgeon whereby the surgeon may select the matching result the surgeon believes is the most likely match via a graphical user interface. Given that the surgeon knows the position of endoscope 12 relative to at least some structures in intra-operative endoscopic image 14, the selection may be relatively straightforward.
- a stage S34 of flowchart 30 encompasses visual servo module 32 generates an endoscopic path within the overlay of the geometrical representation of pre-operative 3D image 44 (FIG. 1) of the blood vessel tree on intra-operative endoscopic image 14 (FIG. 1) of the blood vessel tree. Based on the endoscopic path, visual servo module 32 generates endoscope position commands 25 to robot controller 21 to thereby guide endoscope 12 (FIG. 1) along the endoscopic path to a desired position within the anatomical region. Specifically, once the exact overlay is found, robot 11 may be commanded to guide endoscope 12 to positions the surgeon selects on pre-operative 3D image 44.
- the surgeon or the assistant may select a point of blood vessel tree, and robot 11 may guide endoscope 12 towards that desired position along any suitable path.
- robot 11 may move endoscope 12 along a shortest path 101 to a desired position 100 or along an coronary arterial path 102 to desired position 100.
- Coronary arterial path 102 is the preferred embodiment, because coronary arterial path 102 allows the surgeon to observe visible arteries as robot 11 moves endoscope 12. In addition, it might help the surgeon to decide if the matching was successful.
- Coronary arterial path 102 may be defined using methods known in art (e.g., Dijkstra shortest path algorithm).
- the movement of robot 11 may be commanded using uncalibrated visual servo ing with remote center of motion, and the field of view of endoscope 12 may be extended to enable a larger subgraph during matching stage S32.
- stages S32-S34 may either be executed one time, or on a periodical basis until such time robot 11 has moved endoscope 12 to the desired position within the anatomical region, or multiple times as dictated by the surgeon.
- modules 23 and 24 may be implemented by hardware, software and/or firmware integrated within endoscope controller 22 as shown.
- FIGS. 1-8 From the description of FIGS. 1-8 herein, those having ordinary skill in the art will appreciate the numerous benefits of the present invention including, but not limited to, an application of the present invention to any type of endoscopy surgery performed on any type of blood vessels.
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Abstract
Description
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Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013528806A JP5955847B2 (en) | 2010-09-15 | 2011-09-13 | Endoscopic robot control based on blood vessel tree image |
RU2013116901/14A RU2594813C2 (en) | 2010-09-15 | 2011-09-13 | Robot control for an endoscope from blood vessel tree images |
US13/822,001 US9615886B2 (en) | 2010-09-15 | 2011-09-13 | Robotic control of an endoscope from blood vessel tree images |
BR112013005879A BR112013005879A2 (en) | 2010-09-15 | 2011-09-13 | '' Robot guidance system, control units for an endoscope and robot guidance method '' |
EP11764337.9A EP2615993B1 (en) | 2010-09-15 | 2011-09-13 | Robotic control of an endoscope from blood vessel tree images |
CN201180044480.6A CN103108602B (en) | 2010-09-15 | 2011-09-13 | From the robot controlling of vascular tree image endoscope |
US15/483,615 US10182704B2 (en) | 2010-09-15 | 2017-04-10 | Robotic control of an endoscope from blood vessel tree images |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US38298010P | 2010-09-15 | 2010-09-15 | |
US61/382,980 | 2010-09-15 |
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US13/822,001 A-371-Of-International US9615886B2 (en) | 2010-09-15 | 2011-09-13 | Robotic control of an endoscope from blood vessel tree images |
US15/483,615 Continuation US10182704B2 (en) | 2010-09-15 | 2017-04-10 | Robotic control of an endoscope from blood vessel tree images |
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WO2012035492A1 true WO2012035492A1 (en) | 2012-03-22 |
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Also Published As
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US20170209028A1 (en) | 2017-07-27 |
EP2615993B1 (en) | 2015-03-18 |
US9615886B2 (en) | 2017-04-11 |
US20130165948A1 (en) | 2013-06-27 |
CN103108602B (en) | 2015-09-30 |
EP2615993A1 (en) | 2013-07-24 |
JP2013541365A (en) | 2013-11-14 |
CN103108602A (en) | 2013-05-15 |
RU2013116901A (en) | 2014-10-20 |
US10182704B2 (en) | 2019-01-22 |
BR112013005879A2 (en) | 2016-05-10 |
JP5955847B2 (en) | 2016-07-20 |
RU2594813C2 (en) | 2016-08-20 |
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