WO2011141721A3 - Compositions - Google Patents

Compositions Download PDF

Info

Publication number
WO2011141721A3
WO2011141721A3 PCT/GB2011/000747 GB2011000747W WO2011141721A3 WO 2011141721 A3 WO2011141721 A3 WO 2011141721A3 GB 2011000747 W GB2011000747 W GB 2011000747W WO 2011141721 A3 WO2011141721 A3 WO 2011141721A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
water
active ingredient
insoluble
solvent
Prior art date
Application number
PCT/GB2011/000747
Other languages
French (fr)
Other versions
WO2011141721A2 (en
Inventor
Doris Angus
David John Duncalf
Alison Jayne Foster
Andrew Ian Cooper
Steven Paul Rannard
Dong Wang
Haifei Zhang
Original Assignee
Iota Nanosolutions Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iota Nanosolutions Limited filed Critical Iota Nanosolutions Limited
Publication of WO2011141721A2 publication Critical patent/WO2011141721A2/en
Publication of WO2011141721A3 publication Critical patent/WO2011141721A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)

Abstract

A method for the preparation of a composition comprising a water-soluble porous matrix having a water-insoluble active ingredient dispersed throughout the matrix in the form of nano-particles having a z-average particle size of up to 1000 nm, which process comprises the steps of: (i) providing a preformed porous, water-soluble matrix; (ii) treating the matrix with a solution of the water-insoluble active ingredient in a solvent, wherein the solvent is a non-aqueous solvent in which the matrix is insoluble, whereby the solution permeates through the pores of the matrix; and (iii) removing the solvent by evaporation, thereby leaving the water-insoluble active ingredient in nano- disperse form throughout the matrix. Also disclosed is an identical method using a water-insoluble porous matrix and a water-soluble active ingredient.
PCT/GB2011/000747 2010-05-14 2011-05-13 Compositions WO2011141721A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1008043.0 2010-05-14
GBGB1008043.0A GB201008043D0 (en) 2010-05-14 2010-05-14 Compositions

Publications (2)

Publication Number Publication Date
WO2011141721A2 WO2011141721A2 (en) 2011-11-17
WO2011141721A3 true WO2011141721A3 (en) 2012-02-02

Family

ID=42334754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/000747 WO2011141721A2 (en) 2010-05-14 2011-05-13 Compositions

Country Status (2)

Country Link
GB (1) GB201008043D0 (en)
WO (1) WO2011141721A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109722673B (en) * 2017-10-31 2021-03-12 中国石油化工股份有限公司 Cleaning agent, cleaning agent composition, application thereof and method for treating circulating water system with leaked oil

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003063835A1 (en) * 2002-01-28 2003-08-07 Phares Pharmaceutical Research N.V. Composition comprising low water soluble compounds within porous carriers
US20050048116A1 (en) * 1999-05-27 2005-03-03 Julie Straub Porous drug matrices and methods of manufacture thereof
WO2007133758A1 (en) * 2006-05-15 2007-11-22 Physical Pharmaceutica, Llc Composition and improved method for preparation of small particles
WO2009040818A1 (en) * 2007-09-25 2009-04-02 Solubest Ltd Compositions comprising lipophilic active compounds and method for their preparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050048116A1 (en) * 1999-05-27 2005-03-03 Julie Straub Porous drug matrices and methods of manufacture thereof
WO2003063835A1 (en) * 2002-01-28 2003-08-07 Phares Pharmaceutical Research N.V. Composition comprising low water soluble compounds within porous carriers
WO2007133758A1 (en) * 2006-05-15 2007-11-22 Physical Pharmaceutica, Llc Composition and improved method for preparation of small particles
WO2009040818A1 (en) * 2007-09-25 2009-04-02 Solubest Ltd Compositions comprising lipophilic active compounds and method for their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARELLI V ET AL: "A study of controlled-release systems for progesterone based on crosslinked poly(ethylene oxides)", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 94, no. 1-3, 21 June 1993 (1993-06-21), pages 103 - 113, XP025565534, ISSN: 0378-5173, [retrieved on 19930621], DOI: 10.1016/0378-5173(93)90014-7 *
GANDER B ET AL: "Crosslinked poly(alkylene oxides) for the preparation of controlled release micromatrices", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 5, no. 3, 1 January 1988 (1988-01-01), pages 271 - 283, XP025484168, ISSN: 0168-3659, [retrieved on 19880101], DOI: 10.1016/0168-3659(88)90026-0 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109722673B (en) * 2017-10-31 2021-03-12 中国石油化工股份有限公司 Cleaning agent, cleaning agent composition, application thereof and method for treating circulating water system with leaked oil

Also Published As

Publication number Publication date
GB201008043D0 (en) 2010-06-30
WO2011141721A2 (en) 2011-11-17

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