WO2011021896A2 - Diagnostic system of using diagnostic kit - Google Patents
Diagnostic system of using diagnostic kit Download PDFInfo
- Publication number
- WO2011021896A2 WO2011021896A2 PCT/KR2010/005551 KR2010005551W WO2011021896A2 WO 2011021896 A2 WO2011021896 A2 WO 2011021896A2 KR 2010005551 W KR2010005551 W KR 2010005551W WO 2011021896 A2 WO2011021896 A2 WO 2011021896A2
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- WIPO (PCT)
- Prior art keywords
- diagnostic
- magnetic
- specimen
- diagnostic kit
- sensor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
Definitions
- the diagnostic kit includes a sampling pad on which a specimen is dropped; and a conjugation pad on which the specimen dropped on the sample pad is moved by capillary phenomenon.
- the diagnostic sensor unit may include a magnetic resistance (MR) sensor configured to detect magnetic components of a specimen to which magnetic particles are coupled; a first application unit configured to apply a magnetic field to the magnetic resistance sensor toward a horizontal direction (Y axis), and a second application unit configured to apply a magnetic field to the magnetic resistance sensor toward a vertical direction (Z axis), whereby the detection efficiency can be maximized, where the magnetic resistance sensor may be a GiantMagnetoresistance sensor (GMR).
- GMR GiantMagnetoresistance sensor
- the system may include a diagnostic kit mounting unit (300) configured to mount the diagnostic kit within a measuring device, and a coupling induction unit (400) for controlling mobility of magnetic particles of the specimen is preferably formed at the diagnostic kit mounting unit (300). More preferably, the system further include a diagnostic sensor unit (500) configured to detect magnetic components.
- the conjugation pad (220) is where magnetic particles and detection-antibody capable of specifically coupled with analytes are fixed, and where the analyte forms an immuno-complex using a conjugate coupled by the detection antibody and the magnetic particles specifically reacting.
- the analyte that has failed to react passes a shift pad (230) area of the diagnostic kit by the capillary phenomenon to move to a detection pad (240), whereby an accurate analysis cannot be implemented.
- the specimen is moved to the detection pad (240) through the shift pad (230) to combine with substance such as capture antibody that captures the specimen (immuno-complex) formed at the detection pad (240) and form a secondary immuno-complex for fixation at the detection pad.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Abstract
Disclosed is a diagnostic system of using a diagnostic kit, characterized by: a diagnostic kit accommodating a specimen including magnetic particles; a diagnostic kit mounting unit configured to mount the diagnostic kit; a coupling induction unit configured to control mobility of the magnetic particles in the specimen; and a diagnostic sensor unit configured to detect magnetic components of the specimen.
Description
The present invention relates to an immunochromatography(ICG) quantitative analysis capable of detecting a specimen including magnetic particles.
Generally, a device for detecting or investigating presence of a single material or a plurality of materials in, for example, urine or blood specimen is called a diagnostic kit. To be more specific, the modern diagnostic business field is integrated into a POCT (Point-Of-Care-Testing). The POCT, which is a testing implemented outside of a centralized testing room, is a device that can be used by ordinary people who have no technical or professional knowledge. Currently, the trend is that a diagnostic area is being expanded from hospitals to individuals and on-site areas.
For example, the trendy examples may include a case where there is a need for investigating whether an adequate quantity of antibiotic substance is present in blood by collecting a small quantity of blood after a patient has received a large quantity of antibiotic substances in a hospital to cope with contamination, or a case where types of medicines ingested to guarantee an adequate remedial dosage are needed to be quickly investigated for a recognition function-damaged patient who has ingested an overdose of medicines or an infant who lacks mental capacity to express his or her intention.
Particularly, a rapid diagnostic test represented by an immunochromatography(ICG) quantitative analysis is used in a health-medical field for checking diseases or for grasping changes in diseases, and has been developed as a simple method for quantatively and qualitatively testing a very small quantity of analyte in such fields as food, biological process and environmental fields. Application scope of the immunochromatography(ICG) quantitative analysis is largely expanded to health-medical fields to check pregnancy, ovulation, contagious diseases, overdose of medicines, acute myocardial infarction and cancer.
In the conventional immunochromatography(ICG) analysis system, detection antibody polymerized with markers is accumulated in a dry state on a conjugation pad, and in a case a specimen is added, conjugate is dissolved to react with analyte in a liquid state. The reaction occurs where a specimen solution is in a mobile state resultant from liquid flow generated by capillary phenomenon, and an immuno-complex is formed between the conjugate and the analyte (antigen). The immuno-complex moves upwards of a membrane to be captured by a fixed antibody specifically reacting with analyte and to generate a signal proportionate to the concentration of analyte.
However, there occurs a problem in the conventional membrane chromatography method using a marker and an antibody conjugate, the coupling efficiency of antigen and antibody deteriorates due to diffusion in a laminar flow that is generated through fine pores in the membrane. The problem is caused by a short reaction time for coupling or failure to adjust the reaction time.
Particularly, in order to enhance the reaction between the conventional immuno-chromatography analyte and antibody-conjugate, a special protein is coupled to a marker and antibody conjugate, fixed on a membrane of a diagnostic kit and reacted with analyte (antibody) to form an initial immuno-complex, which is a work to fully obtain a reaction time for forming the initial immuno-complex. The intention is that the initial immuno-complex is formed at a fixed state to restrict the mobility whereby the reaction time can be further obtained.
Thereafter, the initial immuno-complex is desorbed using strong acid or strong base, and the desorbed initial immuno-complex is coupled with secondary antibody to increase the reaction efficiency. However, the process of forming the initial immuno-complex for enhancing the reaction efficiency with analyte (antibody), and the substances such as strong acid and strong base used in the process of desorbing initial immuno-complex can create a negative reaction to a secondary immuno-reaction, thereby making it difficult to perform the quantitative analysis.
The present invention is disclosed to provide a diagnostic system of using diagnostic kit having a high sensitivity analytic performance in which a coupling induction unit that applies a magnetic force capable of controlling mobility of magnetic particles is formed at a measuring system of a diagnostic kit capable of diagnosing a specimen capable of being fixed to magnetic particles to a magnetic force to adjust a reaction time of immuno-complex, whereby a formation rate can be maximized.
Technical problems to be solved by the present invention are not restricted to the above-mentioned, and any other technical problems not mentioned so far will be clearly appreciated from the following description by skill in the art.
An object of the invention is to solve at least one or more of the above problems and/or disadvantages in a whole or in part and to provide at least the advantages described hereinafter. In order to achieve at least the above objects, in whole or in part, and in accordance with the purposes of the disclosure, as embodied and broadly described, there is provided a diagnostic system of using a diagnostic kit, characterized by: a diagnostic kit accommodating a specimen including magnetic particles; a diagnostic kit mounting unit configured to mount the diagnostic kit; a coupling induction unit configured to control mobility of the magnetic particles in the specimen; and a diagnostic sensor unit configured to detect magnetic components of the specimen.
In some exemplary embodiments of the present invention, the diagnostic kit may include a fixation stage; and a feeding unit capable of moving underneath the diagnostic sensor unit by mounting the diagnostic kit at an upper surface of the fixation stage.
In some exemplary embodiments of the present invention, the diagnostic sensor unit may be formed by a magnetic field applying module formed in one or more selected from a solenoid coil, a Helmholtz coil, an electromagnetic yoke and a permanent magnet, whereby a magnetic field is applied to control mobility of reaction time of immuno-complex, and whereby the coupling induction unit is positioned at a bottom surface of the conjugation pad of the diagnostic kit.
In some exemplary embodiments of the present invention, the diagnostic kit includes a sampling pad on which a specimen is dropped; and a conjugation pad on which the specimen dropped on the sample pad is moved by capillary phenomenon.
In some exemplary embodiments of the present invention, the coupling induction unit of the diagnostic system may further include a time-controller configured to control a magnetic force application time.
In some exemplary embodiments of the present invention, the diagnostic sensor unit may include a magnetic resistance (MR) sensor configured to detect magnetic components of a specimen to which magnetic particles are coupled; a first application unit configured to apply a magnetic field to the magnetic resistance sensor toward a horizontal direction (Y axis), and a second application unit configured to apply a magnetic field to the magnetic resistance sensor toward a vertical direction (Z axis), whereby the detection efficiency can be maximized, where the magnetic resistance sensor may be a GiantMagnetoresistance sensor (GMR).
Furthermore, in some exemplary embodiments of the present invention, the coupling induction unit may include a permanent magnet.
A diagnostic system of using diagnostic kit having a high sensitivity analytic performance according to the present invention has an advantageous effect in that a coupling induction unit that applies a magnetic force capable of controlling mobility of magnetic particles is formed at a measuring system of a diagnostic kit capable of diagnosing a specimen capable of being fixed to magnetic particles to a magnetic force to adjust a reaction time of immuno-complex, whereby a formation rate can be maximized.
FIG.1 is a block diagram illustrating a configuration of a detection system according to the present invention.
FIG.2 is a schematic perspective view illustrating a separated diagnostic system of diagnostic kit according to the present invention.
FIG.3 is a schematic view illustrating an operational status of diagnostic system according to the present invention.
FIGS.4 and 5 are schematic views illustrating a diagnostic difference between application of magnetic force and non-application of magnetic force.
The advantages, features and methods for achieving the foregoing will be apparent from the accompanying drawings that follow.
FIG.1 is a block diagram illustrating a configuration of a detection system according to the present invention.
Referring to FIG.1, a diagnostic system may accommodate a specimen including magnetic particles, and the accommodated specimen may form an immuno-complex on a conjugation pad, where a diagnostic kit (200) is used to analyze through magnetic reaction of magnetic particles of the immuno-complex.
Particularly, to this end, the system may include a diagnostic kit mounting unit (300) configured to mount the diagnostic kit within a measuring device, and a coupling induction unit (400) for controlling mobility of magnetic particles of the specimen is preferably formed at the diagnostic kit mounting unit (300). More preferably, the system further include a diagnostic sensor unit (500) configured to detect magnetic components.
FIG.2 is a schematic perspective view illustrating a separated diagnostic system of diagnostic kit according to the present invention.
The diagnostic kit according to the present invention may apply various structural kits used for application of immuno-chromatography.
Now, referring to the illustrated diagram of the conventional diagnostic kit, a sample pad (210) at a position where a specimen including analyte is dropped, and a specimen dropped on the sample pad (210) move to a conjugation pad (220) by capillary phenomenon.
The conjugation pad (220) is where magnetic particles and detection-antibody capable of specifically coupled with analytes are fixed, and where the analyte forms an immuno-complex using a conjugate coupled by the detection antibody and the magnetic particles specifically reacting. In order to form the immuno-complex, there is needed a sufficient time between the analyte and the conjugate, and if no reaction time is obtained, the analyte that has failed to react passes a shift pad (230) area of the diagnostic kit by the capillary phenomenon to move to a detection pad (240), whereby an accurate analysis cannot be implemented.
Therefore, it is an subject matter of the present invention to provide a measuring device at a coupling induction unit (400) capable of sufficiently obtaining a reaction time of a corporate body (hereinafter referred to as "specimen") of a conjugate in which the analyte, the detection antibody and the magnetic particles are coupled at the conjugation pad (220), or controlling a desired reaction time.
The diagnostic system according to the present invention may be mounted with the diagnostic kit mounting unit (300) inside the measuring device (P) in order to allow the diagnostic kit (200) to be mounted, and the diagnostic kit mounting unit (300) is preferably mounted with the coupling induction unit (400).
As illustrated in the figure, the diagnostic kit mounting unit (300) may include a fixation stage (310); and a feeding unit (320) capable of moving underneath a diagnostic sensor unit (500) by mounting the diagnostic kit (200) at an upper surface of the fixation stage (310). It should be apparent that the feeding unit is integrally formed with the fixation stage. The feeding unit is preferably formed in a sliding manner so as to move underneath the diagnostic sensor unit (500). The coupling induction unit (400) is preferably formed at the fixation stage in this structure.
At the same time, in a case the coupling induction unit (400) is mounted with a diagnostic kit for analysis, the coupling induction unit is more preferably formed at a lower surface of the conjugation pad (220) area. The configuration is to control a coupled time in which the analyte, the detection antibody and the magnetic particles are coupled. That is, the coupling induction unit (400) is intended to apply a magnetic force to the magnetic particles, thereby controlling mobility of the analyte that is coupled with the magnetic particles.
Furthermore, the diagnostic sensor unit (500) can utilize various magnetic field application modules configured to apply a magnetic force. For example, the coupling induction unit may be formed by a magnetic field applying module formed in one or more selected from a solenoid coil, a Helmholtz coil, an electromagnetic yoke and a permanent magnet.
In addition, the coupling induction unit (400) may include a permanent magnet. The reaction time of the coupling induction unit (400) may be adjusted by setting up a desired reaction time to allow automatically escaping from the magnetic force, in a case the permanent magnet is to be used to cause the diagnostic kit to move underneath the diagnostic sensor unit (500) through the feeding unit (320) of the diagnostic kit mounting unit (300).
In a case of using a unit that generates a magnetic force by applying an outside current, for example, a solenoid coil or a Helmholtz coil, the method of adjusting the reaction time through the feeding unit (320) as in the case of using the permanent magnet may be utilized. However, the interruption of current may also simply adjust the reaction time.
Now, referring to FIGS. 2 and 3, an operational status of diagnostic system according to the present invention will be schematically described.
The diagnostic kit mounting unit (300) may be formed inside the measuring device (P), where the diagnostic kit mounting unit (300) may be formed in a structure drawable to the outside. At the same time, in a case the diagnostic kit (200) is installed at an upper surface of the feeding unit (320) of the diagnostic kit mounting unit (300), a specimen (S) including the analyte is dropped on the sample pad (210), and a reaction is implemented where the analyte is coupled by the magnetic particles and immunogloblin by capillary phenomenon at the conjugation pad (220) to form a specimen (immuno-complex).
The coupling reaction time may be adjusted by restricting the mobility of the magnetic particles using the coupling induction unit (400) that applies magnetic force. Following the lapse of sufficient reaction time, the feeding unit (320) is moved toward the diagnostic sensor unit (500) to remove the magnetic force, or to interrupt the current to adjust the reaction time in a case the coupling induction unit that generates the magnetic force through the current is formed.
In a case the magnetic force is removed by the coupling induction unit (400), the specimen (immuno-complex including the magnetic particles) is moved to the detection pad (240) through the shift pad (230) to combine with substance such as capture antibody that captures the specimen (immuno-complex) formed at the detection pad (240) and form a secondary immuno-complex for fixation at the detection pad.
Successively, the magnetic force change in the magnetic particles is detected by the diagnostic sensor unit (500) or the color of the magnetic particles is detected to detect a coloring signal (coloring signal is generated in proportion to concentration of analyte), whereby the analyte is grasped.
In case of implementing the quantatative analysis during detection process, it is preferable to constantly maintain the reaction time for accurate measurement, and to this end, the coupling induction unit (400) according to the present invention may further include a time-controller configured to control a magnetic force application time.
The time-controller may adjust the magnetic force application time through a function of controlling a time to remove the magnetic force of the coupling induction unit or a time to remove supply of current by moving the feeding unit.
At the same time, the diagnostic sensor unit (500) according to the present invention may use a sensor configured to detect a coloring signal of the magnetic particles using the magnetic particles as marker, and may further use a sensor configured to use the magnetic resistance (MR)sensor. Particularly, the method of using the magnetic resistance sensor is a method of detecting the magnetic force change of the magnetic particles having a specimen by applying magnetic force to the specimen from outside, where the magnetic resistance sensor may further include an outside magnetic field application device that applies magnetic field to the magnetic resistance sensor from the outside.
In this case, the magnetic resistance sensor configured to detect the magnetic components of the specimen coupled with magnetic particles may include a first application unit configured to apply a magnetic field to the magnetic resistance sensor toward a horizontal direction (Y axis), and a second application unit configured to apply a magnetic field to the magnetic resistance sensor toward a vertical direction (Z axis), whereby the detection efficiency can be maximized, because much-reinforced magnetic force can be obtained by the magnetic field applied from two axial (vertical and horizontal) directions.
Preferably, the magnetic resistance sensor may be selected from one of a group comprising an OMR (Ordinary Magnetoresistance) sensor, an AMR (Anisotropic Magnetoresistance) sensor, a GMR (GiantMagnetoresistance) sensor, a CMR (Colossal Magnetoresistance) sensor, a TMR (Tunnelling Magnetoresistance) sensor, a MJT (Magnetic Tunnelling Junction) sensor, and a planar Hall resistance sensor. Particularly, the magnetic resistance sensor may be a GiantMagnetoresistance sensor (GMR).
With reference to FIGS. 4 and 5, FIGS.4 and 5 are schematic views illustrating a comparative experimental data between obtainment of reaction time by application of magnetic force and non-obtainment of reaction time by application of magnetic force using the coupling induction unit according to the present invention.
As noted from data in FIGS.4 and 5, detection sensitivity based on concentration of analyte is abruptly increased by application of magnetic force (2 minutes).
The diagnostic system of using a diagnostic kit according to the present invention has industrial applicability in that a diagnostic system can be provided that is capable of adjusting a reaction time of an immuno-complex.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, the general inventive concept is not limited to the above-described embodiments. It will be understood by those of ordinary skill in the art that various changes and variations in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the following claims.
Claims (9)
- A diagnostic system of using a diagnostic kit, characterized by: a diagnostic kit accommodating a specimen including magnetic particles; a diagnostic kit mounting unit configured to mount the diagnostic kit; a coupling induction unit configured to control mobility of the magnetic particles in the specimen; and a diagnostic sensor unit configured to detect magnetic components of the specimen.
- The diagnostic system of claim 1, characterized in that the diagnostic kit includes a fixation stage; and a feeding unit capable of moving underneath the diagnostic sensor unit by mounting the diagnostic kit at an upper surface of the fixation stage.
- The diagnostic system of claim 1, characterized in that the diagnostic sensor unit is formed by a magnetic field applying module formed in one or more selected from a solenoid coil, a Helmholtz coil, an electromagnetic yoke and a permanent magnet.
- The diagnostic system of claim 1, characterized in that the diagnostic kit includes a sampling pad on which a specimen is dropped; and a conjugation pad on which the specimen dropped on the sample pad is moved by capillary phenomenon.
- The diagnostic system of claim 4, characterized in that the coupling induction unit is positioned at a bottom surface of the conjugation pad of the diagnostic kit.
- The diagnostic system of claim 5, characterized in that the coupling induction unit further includes a time-controller configured to control a magnetic force application time.
- The diagnostic system of claim 6, characterized in that the diagnostic sensor unit includes a magnetic resistance (MR) sensor configured to detect magnetic components of a specimen to which magnetic particles are coupled; a first application unit configured to apply a magnetic field to the magnetic resistance sensor toward a horizontal direction (Y axis), and a second application unit configured to apply a magnetic field to the magnetic resistance sensor toward a vertical direction (Z axis).
- The diagnostic system of claim 7, characterized in that the magnetic resistance sensor is a GiantMagnetoresistance sensor (GMR).
- The diagnostic system of claim 4, characterized in that the coupling induction unit includes a permanent magnet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2009-0077428 | 2009-08-21 | ||
| KR1020090077428A KR20110019843A (en) | 2009-08-21 | 2009-08-21 | Diagnostic system of using diagnostic kit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2011021896A2 true WO2011021896A2 (en) | 2011-02-24 |
| WO2011021896A3 WO2011021896A3 (en) | 2011-07-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2010/005551 WO2011021896A2 (en) | 2009-08-21 | 2010-08-20 | Diagnostic system of using diagnostic kit |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR20110019843A (en) |
| WO (1) | WO2011021896A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11366065B2 (en) | 2017-02-03 | 2022-06-21 | Samsung Life Public Welfare Foundation | Point-of-care system and method for diagnosing acute febrile illness |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102256775B1 (en) * | 2016-09-29 | 2021-05-27 | (주)바이오니아 | Apparatus of treating biological sample |
| WO2018143684A1 (en) * | 2017-02-03 | 2018-08-09 | 사회복지법인 삼성생명공익재단 | Point-of-care system and method for diagnosing acute febrile illness |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238810A (en) * | 1986-09-22 | 1993-08-24 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus thereof |
| JP4090722B2 (en) * | 2001-10-23 | 2008-05-28 | 純一 小川 | Magnetic fluid detection device |
| US6571934B1 (en) * | 2001-11-14 | 2003-06-03 | Dade Behring Inc. | Bi-directional magnetic sample rack conveying system |
| US8936946B2 (en) * | 2007-06-20 | 2015-01-20 | Board Of Trustees Of Michigan State University | Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications |
-
2009
- 2009-08-21 KR KR1020090077428A patent/KR20110019843A/en not_active Application Discontinuation
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- 2010-08-20 WO PCT/KR2010/005551 patent/WO2011021896A2/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11366065B2 (en) | 2017-02-03 | 2022-06-21 | Samsung Life Public Welfare Foundation | Point-of-care system and method for diagnosing acute febrile illness |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110019843A (en) | 2011-03-02 |
| WO2011021896A3 (en) | 2011-07-07 |
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