WO2010040803A3 - Kv1.3 channel blocking substances for the treatment of diseases associated with intimal hyperplasia - Google Patents
Kv1.3 channel blocking substances for the treatment of diseases associated with intimal hyperplasia Download PDFInfo
- Publication number
- WO2010040803A3 WO2010040803A3 PCT/EP2009/063099 EP2009063099W WO2010040803A3 WO 2010040803 A3 WO2010040803 A3 WO 2010040803A3 EP 2009063099 W EP2009063099 W EP 2009063099W WO 2010040803 A3 WO2010040803 A3 WO 2010040803A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- channel blocking
- intimal hyperplasia
- diseases associated
- blocking substances
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a therapeutic tool against intimal hyperplasia consisting of the use of Kv1.3 channel blocking substances, able to selectively stop cell migration and multiplication of VSMCs.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09783852.8A EP2346503B1 (en) | 2008-10-08 | 2009-10-08 | Kv1.3 channel blocking substances for the treatment of diseases associated with intimal hyperplasia |
US13/123,220 US8629110B2 (en) | 2008-10-08 | 2009-10-08 | Kv1.3 channel blocking substances for the treatment of diseases associated with intimal hyperplasia |
ES09783852T ES2436035T3 (en) | 2008-10-08 | 2009-10-08 | Kv1.3 channel blocking substances for the treatment of diseases associated with intimal hyperplasia |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08105518 | 2008-10-08 | ||
EP08105518.8 | 2008-10-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010040803A2 WO2010040803A2 (en) | 2010-04-15 |
WO2010040803A3 true WO2010040803A3 (en) | 2010-06-03 |
Family
ID=41360303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/063099 WO2010040803A2 (en) | 2008-10-08 | 2009-10-08 | Kv1.3 channel blocking substances for the treatment of diseases associated with intimal hyperplasia |
Country Status (4)
Country | Link |
---|---|
US (1) | US8629110B2 (en) |
EP (1) | EP2346503B1 (en) |
ES (2) | ES2345527B1 (en) |
WO (1) | WO2010040803A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014028502A1 (en) * | 2012-08-13 | 2014-02-20 | ImmunGene Inc. | Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases |
TW201427947A (en) | 2012-10-12 | 2014-07-16 | Lundbeck & Co As H | Cyclic amines |
TWI598325B (en) * | 2012-10-12 | 2017-09-11 | H 朗德貝克公司 | Benzamides |
TWI698438B (en) | 2015-03-13 | 2020-07-11 | 德商4Sc製藥公司 | Kv1.3 inhibitors and their medical application |
TWI701249B (en) | 2015-03-13 | 2020-08-11 | 德商4Sc製藥公司 | Kv1.3 inhibitors and their medical application |
CA3149158A1 (en) * | 2019-07-31 | 2021-02-04 | Sea4Us - Biotecnologia E Recursos Marinhos, Lda. | Kv1.3 antagonists for use in the treatment of chronic and acute pain |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5116864A (en) * | 1991-04-09 | 1992-05-26 | Indiana University Foundation | Method for preventing restenosis following reconfiguration of body vessels |
WO1993007748A2 (en) * | 1991-10-23 | 1993-04-29 | The General Hospital Corporation | Laser-based inhibition of smooth muscle cell hyperproliferation |
WO1997005127A1 (en) * | 1995-07-27 | 1997-02-13 | Pdt Systems, Inc. | Photoactivatable compounds for the prevention of intimal hyperplasia and other diseases |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5354774A (en) * | 1992-12-24 | 1994-10-11 | Yale University | Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light |
PE20081140A1 (en) | 2006-10-25 | 2008-09-22 | Amgen Inc | THERAPEUTIC AGENTS BASED ON PEPTIDES DERIVED FROM TOXINS |
-
2009
- 2009-01-30 ES ES200900281A patent/ES2345527B1/en not_active Expired - Fee Related
- 2009-10-08 EP EP09783852.8A patent/EP2346503B1/en not_active Not-in-force
- 2009-10-08 US US13/123,220 patent/US8629110B2/en not_active Expired - Fee Related
- 2009-10-08 WO PCT/EP2009/063099 patent/WO2010040803A2/en active Application Filing
- 2009-10-08 ES ES09783852T patent/ES2436035T3/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5116864A (en) * | 1991-04-09 | 1992-05-26 | Indiana University Foundation | Method for preventing restenosis following reconfiguration of body vessels |
WO1993007748A2 (en) * | 1991-10-23 | 1993-04-29 | The General Hospital Corporation | Laser-based inhibition of smooth muscle cell hyperproliferation |
WO1997005127A1 (en) * | 1995-07-27 | 1997-02-13 | Pdt Systems, Inc. | Photoactivatable compounds for the prevention of intimal hyperplasia and other diseases |
Non-Patent Citations (1)
Title |
---|
CHEONG ALEX ET AL: "Blockers of Kv1.3 channel suppress smooth muscle response to injury and neointimal hyperplasia", April 2007, FASEB JOURNAL, VOL. 21, NR. 5, PAGE(S) A69, EXPERIMENTAL BIOLOGY 2007 ANNUAL MEETING; WASHINGTON, DC, USA; APRIL 28 -MAY 02, 2007, ISSN: 0892-6638, XP009126798 * |
Also Published As
Publication number | Publication date |
---|---|
ES2345527B1 (en) | 2011-09-08 |
US8629110B2 (en) | 2014-01-14 |
ES2436035T3 (en) | 2013-12-26 |
EP2346503B1 (en) | 2013-07-17 |
EP2346503A2 (en) | 2011-07-27 |
US20110275571A1 (en) | 2011-11-10 |
ES2345527A1 (en) | 2010-09-24 |
WO2010040803A2 (en) | 2010-04-15 |
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