WO2009118761A2 - Metallized paper based lidding material for blister packaging & process thereof - Google Patents
Metallized paper based lidding material for blister packaging & process thereof Download PDFInfo
- Publication number
- WO2009118761A2 WO2009118761A2 PCT/IN2009/000196 IN2009000196W WO2009118761A2 WO 2009118761 A2 WO2009118761 A2 WO 2009118761A2 IN 2009000196 W IN2009000196 W IN 2009000196W WO 2009118761 A2 WO2009118761 A2 WO 2009118761A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- paper
- lidding material
- coat
- multilayered
- layer
- Prior art date
Links
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Classifications
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- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/70—Food packaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
Definitions
- the present invention relates to lidding material.
- the present invention relates to lidding material for blister packaging.
- Blister packing is a common form of packaging used for a wide variety of products such as food articles, pharmaceutical preparations, toys and the like. Blister packing is safe and easy to use and can allow the consumer to see the packaged contents without opening the pack when at least one surface of said blister pack is made of a transparent material such as PVC plastics.
- a commonly available blister pack has two surfaces. One surface has cavities at predetermined places to hold the desired article and the other surface acts as a lid.
- the lidding material in the form of, for example a foil, is attached or fixed over the open surface of the cavity.
- the lidding material may be burst opened or torn in a suitable fashion to release the article off.
- packing can be made, especially with respect to the material and the releasing mechanism used to arrive at a suitable blister pack.
- the most commonly used materials for forming blister are polymer based, such as PVC (polyvinyl chloride) plastics.
- PVC polyvinyl chloride
- blisters may be transparent, semi- transparent or opaque.
- polymeric films or aluminium foils are used as lidding materials.
- One side of the lidding material is also used for printing the product information and usage instructions. The lidding material is fixed to the surface having cavities through heat sealing mechanism or just by application of adhesive.
- Completely paper-based lidding materials are suitable for articles that are insensitive to moisture or surrounding environment, such as plastic toys, batteries and the like.
- purely paper based lidding materials do not have enough strength and barrier properties required for packaging of articles that are sensitive to environment such as food items and pharmaceutical preparations.
- the use of such materials like paper have serious disadvantage that these materials does not provide optimum barrier towards moisture, which is the one of the most essential requirements of the lidding material used in packaging of pharmaceutical products.
- Such articles are often packed in blisters that use aluminium foil as lidding material due to its higher barrier properties.
- Such foils can provide adequate moisture or gas barrier, a thin gauge material with eventual printability and desirable push through characteristics.
- such lidding materials also have disadvantages of high cost, the necessity of treatment or surface coating to achieve printability, difficulty in recycling the entire package after use and curling of finished packages.
- paper As discussed above, the use of paper as lidding material in the pharmaceutical product application is limited till date due to stringent packaging requirements. Paper offers very less resistance to the water vapour due its inherent highly porous nature; also it has less tear strength.
- lidding material is made from polyamide or polyurethane or PVC. Although such lidding materials solve many of the problems listed above, their primary disadvantage is the difficulty encountered in recycling of the empty blister package.
- lidding materials that have strength and barrier properties comparable to aluminum foils, but are cheaper than the currently used aluminum foils and can be easily recycled also.
- WO 2005/123515 relates to a multilayered material which is peelable and heat-sealable, suitable to bonding with variety of substrates that can be used as a lid on a container, said multilayered material consisting of a solid substrate which is joined to an aliphatic- aromatic co-polyester film.
- One of the components of aliphatic-aromatic co-polyester film may be biodegradable, and further consists of inorganic fillers of size 0.5 to 10 micrometer and other polymers and copolymers containing butane- 1 polymer and ethylene-vinyl acetate copolymer.
- Said lidding material can be easily bonded to polystyrene, PP, PE, PVC, PET and PVdC packaging containers.
- the invention mainly relates to a lidding material for the container for packing contact lenses having saline solution.
- the lidding material prepared in this prior art is meant for easy peelable property.
- WO 82/03202 relates to a multilayer metallized paper based material.
- a layer of thermoplastic resin is extruded above the paper substrate.
- the thermoplastic layer is sandwiched between the paper layer and the metal layer.
- the function of the thermoplastic layer is to aid in the metallization of paper substrate as paper substrate by itself has difficulties in the process metallization. However, this adds to the cost of manufacturing of the metallized paper.
- EP Patent Application 0 267 395 relates to preparation of glossy paper material for metallization purpose.
- the glossy appearance of paper was attainted by laminating an interleaving film and programmed flowable thermoplastic resin material with paper substrate.
- the programming of flowability of the thermoplastic resin was maintained by applying proper pressure and temperature.
- interleaving film was stripped away to leave glossy thermoplastic resin coated paper substrate for metallization.
- Metallization of paper can be achieved both by direct and indirect metallization processes.
- This Patent application necessarily relates to a process to be carried out to get glossy substrate before metallization of the paper substrate.
- metallization of paper substrate in the above patent has a layer of glossy thermoplastic resin over paper substrate, which further adds to the cost and complexity of the process.
- US Patent 4,434,259 deals with an improved base coating that can be used on the paper substrate which can be further vacuum metallized.
- the inventors used copolymer of vinyl acetate and acrylic acid in the weight ratio of 97.5-99: 1-2.5 or 94-97 % weight and 3-6% weight of monoethyl maleate.
- the base coat thus prepared enhances the adhering of metal to the paper substrate and the metallized paper is further used for the decorative purpose or as label for bottles.
- such coated papers are not suitable for use as lidding material for blister packs to be used in pharmaceutical industry.
- US Patent 6,086,988 deals with a recyclable lidding material with Polyvinyl Chloride (PVC) bottom in push through packages.
- the lidding material disclosed in this US Patent uses a rigid PVC base resin with addition of two types of filler materials. These filler materials regulate the frangibility of the lidding material and its vapour barrier characteristics.
- One of the filler materials used in this invention is calcium carbonate with irregular particles shape and sizes while second filler material is magnesium silicate hydrate or talc. Function of first filler material is to regulate initiation of tearing in the lidding material while the second material governs the brittleness of lidding material and completion of tearing process.
- the process disclosed in the aforementioned prior art is a tedious one and is also costly.
- US Patent application 3,938,659 relates to a making a sterilized package.
- the sterilized package is made up of a base paper joined with polymeric closure using heat sealing process.
- a blush lacquer is used between the heat seal lacquer and the paper layer.
- the blush lacquer forms cohesive bond with heat seal lacquer so that when the peeling of the package is done, the peeling process will occur only at the blush lacquer layer and not at the paper layer. This ensures the breaking of bond between blush lacquer and heat seal lacquer and avoid peeling of paper.
- US patent application 6254570 relates to method of making a substrate for heat transfer label.
- Heat transfer labels are used to transfer printing on substrate by heat transfer process.
- the substrate to be printed is typically a polymer surface where the printing ink is transferred from a carrier to the substrate to be printed.
- the label is a multilayer material which comprises a carrier substrate which included a support carrier substrate in the form a paper and an adhesive which is UV or EB curable, a transfer release agent in the form a low melting wax and printing ink layer.
- a wax coating acts as a releasing agent that releases the printing ink to the substrate at high temperature.
- One object of the present invention is to provide a lidding material.
- Another object of the present invention is to provide a lidding material for blister packaging.
- Yet another object of the present invention is to provide a lidding material for blister packaging that is suitable for application in pharmaceutical industries, food industries and the like, particularly for packaging of those commodities which are sensitive to surrounding environment.
- Still another object of the present invention is to provide a lidding material which possesses good barrier property against water vapour, moisture and the like.
- Still another object of the present invention is to provide a lidding material which is inert in nature and does not alter the properties of the contents packed.
- Still another object of the present invention is to provide a lidding material which can easily be sealed to the blister pack and provides good resistance to high temperature and pressure.
- Still another object of the present invention is to provide a lidding material which possesses significantly higher push through strength and tearing strength making it more child resistant package and more challenging for children to access the medication from the package.
- Still another object of the present invention is to provide a lidding material which is cheaper than the existing lidding materials. Still another object of the present invention is to provide a lidding material which can easily be recycled besides being aesthetic.
- a high temperature and pressure resistant multilayered lidding material for packaging of pharmaceutical products comprising: a) a paper layer having a mass per unit area of about 20 to 100 g/m 2 , said paper layer defined by an operative inner surface facing the product to be packed and an operative outer surface; b) a primer coat applied on said outer surface; c) a metal layer of thickness of about 0.02 to 0.1 microns deposited on said primer coat; d) a high temperature and pressure resistant lacquer coat applied on said metal layer; e) optionally a printing layer applied between said metal layer and said lacquer coat; f) a sealing coat applied on said operative inner surface of said paper; and g) optionally a barrier coat between said paper and sealing coat
- said paper is selected from a group of materials consisting of glassine paper, craft paper, poster paper, map litho paper and sulphated paper.
- said primer is a polymer selected from a group of polymers consisting of nitrocellulose based polymers, acrylic based polymers and polyester based polymers.
- said primer coat has a thickness of about 0.5 to 10 gsm.
- said metal is selected from a group of metals consisting of aluminum, gold, silver, copper, platinum, palladium, tin, and metal alloys viz., brass and bronze.
- said metal layer is deposited by a method selected from a group consisting of a plurality of methods viz., direct vacuum metallization process, indirect metallization process and application of a metallic ink lacquer. ,
- said lacquer coating is a polymeric substance selected from a group of polymers consisting of nitrocellulose, polyester and acrylic based polymers.
- said lacquer coating is mixed with the release lacquer composition for indirect metallization process, applied directly on the metallized side of the paper after direct metallization of the paper or during the printing of the surface.
- said printing layer has a thickness in the range of about 0.5 to 10 gsm.
- said printing layer is a coloured layer.
- said coloured layer is obtained by colouring said printing layer with a coloured pigment or coloured lacquer.
- said sealing coat is a polymer coat selected from a group of polymers and copolymers consisting of vinylic polymer, vinylic copolymer, copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
- said sealing coat is a heat sealing coat.
- said sealing coat has a thickness of about 1 to 10 gsm.
- said barrier coat is a PVdC coat having a thickness in the range of about 5 to 40 gsm.
- said barrier coat is applied by a process selected from a group of processes consisting of gravure coating, reverse gravure coating and doctoring.
- a blister packaging comprising a combination of a polymer blistered laminate and said lidding material.
- Fig. 1 illustrates a partial sectional view of a typical lidding material in accordance with the present invention.
- the inventors of the present invention have comprehensively and successfully investigated the possibility of developing such a highly desired cheaper lidding material and have unexpectedly developed a paper based lidding material for blister pack having excellent strength, barrier properties and look like aluminium foil which provide an opaque surface for printing and are cheaper than aluminium foils. They provide good resistance towards high temperature and pressure.
- the inventors of this invention have come up with a paper based lidding material which is aesthetically appealing, provides a printable surface with opacity of more than 90% for proper legibility of printed matter. Further, the paper and the printed matter are able to withstand high temperature and pressure during the sealing as well as printing operations and also withstand possible abrasions during transit.
- the present invention provides a high temperature and pressure resistant multilayered lidding material for packaging of pharmaceutical products generally indicated by reference numeral 100 as shown in Fig. 1, said lidding material comprising:
- pharmaceutical product refers to various types of drugs including food and nutritional supplements.
- paper refers to a sheet of paper having one or more stratum of paper.
- coating includes applying, layering and pressing or deposition of metal by vacuum evaporation process or by indirect metallization process or by using metallic ink pigment.
- Various types of paper suitable for the preparation of high temperature and pressure resistant multilayered lidding material in accordance with this invention include glassine paper, craft paper, poster paper, map litho paper and sulphated paper.
- the primer used for coating the operative outer surface of the paper is a polymer.
- Nitrocellulose based polymers, acrylic based polymers and polyester based polymers are some examples of such polymers suitable for primer coating.
- the primer coat has a thickness of about 0.5 to 10 gsm.
- the paper can be metallized with different types of metals like aluminum, gold, silver, copper, platinum, palladium, tin, etc. Further, metal alloys like brass and bronze may also be used for metallization of the paper.
- the metal layer may be deposited by any suitable methods known in the prior art such as direct vacuum metallization process, indirect metallization process and application of metallic ink lacquer/pigment.
- a high temperature and pressure resistant lacquer coat of a polymeric substance is applied on to the metal layer, which is of utmost importance during the formation of blister packages since blister packaging involves employment of high temperatures and pressure at various stages of development of the package.
- the lacquer coat of the polymeric substance is a resinous material like nitrocellulose, polyester and acrylic based polymers.
- the method used for coating the lacquer on the metallized paper may vary depending on the type of metallization method used.
- the lacquer coating is mixed with the release lacquer composition for Indirect metallization process, whereas the lacquer coating is applied directly on the metallized side of the paper after Direct metallization of the paper.
- the lacquer coating can also be applied during the printing of the surface. Printing of the information pertaining to the contents of the package is of utmost importance for the manufacturers as well as the consumers. In this regard, a good printing layer is necessary for any blister packaging system. A. printing layer of a thickness of about 0.5 to 10 gsm is found to be optimum for this purpose.
- the printing layer is preferably chosen to be a coloured layer. This can be achieved by colouring the printing layer with a coloured pigment or a coloured lacquer.
- the final sealing of the lidding material to the blister pack containing the pharmaceutical products is one of the most important steps during blister packaging. Such sealing should be air-tight inorder to preserve the contents of the package.
- the sealing coat used in this invention is a polymer coat like vinylic polymer, vinylic copolymer, copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
- the sealing coat is a heat sealing coat and has a thickness of about 1 to 10 gsm.
- a barrier coat between the paper and the sealing coat is optional. However, it is advisable to provide at least one such barrier coat in order to increase the strength of the paper and its shielding capacity against water vapour, gases and other material which will influence the activity of the pharmaceutical or food product.
- a polyvinyl dichloride layer (PVdC) coat having a thickness in the range of about 5 to 40 gsm is found to be a good choice for such as barrier.
- the barrier coat may be applied by any process known to a person skilled in the art like gravure coating, reverse gravure coating and doctoring.
- a blister packaging comprising a combination of a polymer blistered laminate and said lidding material.
- this invention provides a multilayered lidding material for blister packaging comprising a paper layer having first operative layer (facing the cavity or inner surface) coated with optional barrier layer and sealing layer while, second surface (facing opposite to the cavity or outer surface) coated with metallized layer by a method of indirect metallization process or direct vacuum metallization process. Further, the metallized paper is optionally coated with lacquer layer for obtaining printable surface.
- the lidding material according to this invention comprises a paper layer sandwiched between a barrier coat and sealing coat on one side and a metal layer and an optional lacquer coat suitable for printing on the other side.
- the present invention provides a lidding material for blister pack comprising a paper layer coated with a primer coat, metal layer, a temperature resistant lacquer coat, a heat seal lacquer coat and optionally coated with at least one barrier coat on sealing side of the paper prior to heat seal lacquer coat, a color lacquer coat on metallized side.
- the paper layer comprises at least one paper selected from a group consisting of glassine paper, craft paper, yellow parchmentine paper, tracing paper, super calendared paper, poster paper, chromed paper, white super calendared glassine paper, red super calendared glassine paper and white poster paper.
- the thickness of the paper layer depends on the desired properties. Preferably, the thickness of the paper layer is about 25 to 100 gsm. However, thickness outside this range may also be advantageously employed if desired.
- Lidding material is essential part of blister packaging.
- the lidding part provides the Hd to the product enclosed in the cavity of packaging as well as it also provides barrier against water vapour, gases and other material which will influence the activity of the pharmaceutical or food product.
- the lidding material in this invention is used for the packaging of pharmaceutical product therefore, it is utmost important that the material used should be biocompatible and the does not release any hazardous constituents during the storage of the product.
- paper and polymeric materials are generally used.
- the lidding material should also provide enough strength and easy tearing property so that user or consumer can easily have access to the packaged product.
- paper has it's own disadvantages such as it is porous in nature which restricts the use of paper as lidding material in pharmaceutical product packaging as water vapour and other gases can easily pass through the paper which deteriorates the pharmaceutical product. Also, it can be easily attacked by acid and alkali atmosphere.
- the inventors in the present invention have come out with a new paper based lidding material in which a metal layer is deposited or provided on one side of the paper lidding material.
- the inventors have prepared a paper based lidding material without the use of any polymeric film.
- a metallized paper based lidding material can be prepared by coating the paper by a metal pigment nitrocellulose based ink.
- the metal ink provides a matte finish to paper. Further, it also improves the opacity of the paper and provides an opaque printable surface. Generally, the opacity of paper is required to be above 90%. To achieve this opacity, the percentage of metal pigment in ink is between 15 to 17%. Below this percentage the opacity of the paper will be low and above which the uniform layer of metal ink will not be obtained and can give printing problems such as mottling effect. Therefore, the optimum working range of the ink is 15 to 17%.
- the base of the ink is nitrocellulose resin which is around 10 to 12%, and it has temperature and pressure resistant property.
- a silicon oil based slip additive is mixed with the ink.
- This slip additive ensures the uniform spreading of ink on the paper surface, usually intermolecular friction is present in the pigment. This friction leads to nonuniform layer formation of metal ink on the surface, however, when slip additives are added to ink, the slip additive reduces the friction and forms a uniform layer of ink. Amount more than 0.05% of slip additive will pose a difficulty in printing operation.
- a printing ink lacquer is applied by the known method of gravure coating process. However, during the sealing operation, the printing ink is usually unable to withstand the sealing temperature and is leached out from the metal surface. To avoid this, an overcoat of nitrocellulose based lacquer of thickness between 0.5 to 10 GSM is applied.
- Metallization of the paper lidding material was carried out by two different methods like direct metallization and indirect metallization.
- direct metallization a metal layer was directly deposited on paper lidding material while in case of indirect metallization, the metallization of paper was carried out by transferring a metal layer from metallized biaxially oriented polyethylene terphthalate film.
- a specially developed primer coat was applied on the paper.
- the primer coat imparts adhesion of the metal layer on paper uniformly and ensures strong adhesion of the metal layer on the paper even after the processing for sealing with polymeric blisters. Further, it improves the glossy appearance of the metallized paper.
- Special nitrocellulose based primer coat was developed for direct metallization process and thickness of the primer coat was between 0.5 to lOgsm.
- Vacuum metallization is a process in which an ulra-thin layer of metal deposited on a substrate such as plastic, glass, paper and the like to achieve a metallic surface appearance.
- Metallizing directly on paper results in a totally unacceptable material, i.e. paper with dull surface. This is due to the rough texture of paper surface. Since the deposited metal adheres directly to the surface of the substrate being metallized and also since the resulting metal coating thickness is about 250 to 300 A, the direct deposition of metal on paper yields an unacceptable product.
- the surface of paper is typically coated with a base coating can be called as a 'primer coat' which fills minor surface imperfections and provides smooth surface to receive metal deposition.
- the properties which are important in base coat or primer coat are adhesion, water resistance and block resistance.
- the metal is deposited on paper substrate by two different processes such as direct metallization and indirect metallization and surprisingly the inventors found that the two metallization processes imparted different metallic appearances to the paper substrate and this may be due a role played by primer coat used.
- the inventor used nitrocellulose based base coat in both the types of metal deposition process.
- Indirect metallization process of paper based lidding paper material is carried out by lamination and delamination process. Initially bi-axially oriented polyester film is coated with release coat of silicon based material, followed by metallization of desired thickness. Subsequently, this metallized film is laminated with paper substrate to be metallized and polyester film is separated from paper substrate by delamination method. This delamination process ensures transfer of metal from polyester film to the paper substrate. Also, as the surface of the oriented polymeric film is very smooth, this enhances the gloss of the metallized paper.
- the barrier coat imparts barrier properties to the lidding material.
- the barrier coat comprises at least one polymer.
- the barrier coat comprises PVdC.
- the thickness of the barrier coat depends on the desired barrier properties. Preferably, the thickness of the barrier coat is about 5 to 40 gsm. However, thickness outside this range may also be advantageously employed if desired.
- the heat sealing coat is useful in sealing the lidding material with the base material of the blister.
- the heat sealing coat comprises at least one vinylic polymer or a vinylic copolymer.
- the heat sealing coat comprises at least one material selected from a group consisting of copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
- the inventors have also modified the path of the sealing machine by adding "an addler" in the path of the heater and the paper roll unwinder. This addition ensures short contact time of metallized paper with heater. The path is so modified that, the sealing time is sufficient to seal the metallized paper lidding material with polymeric blister at the same time avoid the de-lamination of metal from paper surface due to presence of high temperature.
- the thickness of the heat sealing depends on the desired sealing properties.
- the thickness of the heat sealing coat is about 1 to 10 gsm. However, thickness outside this range may also be advantageously employed if desired. It is found that during sealing operation, temperature of sealing heater is above 200° C which results in delamination of metal from the paper surface. The inventors found that the thickness of the sealing coat decides the stability of metal layer. Generally thickness of the sealing coat is ⁇ 5 GSM, however, at this thickness, the metal layer leached out. Therefore, inventors varied the thickness of sealing coat from 5 GSM up to 10 GSM.
- temperature and pressure resistant lacquer on metal layer.
- Application of temperature and pressure resistant lacquer on the metallized paper can be achieved either by directly coating the lacquer layer on metal by known processes such gravure coating process or adding temperature and pressure resistant resins in the release lacquer which is used in indirect metallization process.
- the release lacquer comprises of silicon based lacquer which is mixed with temperature and pressure resistant resins.
- Temperature and pressure resins comprise resins from a group of resins selected from nitrocellulose based resins, acrylic and polyester based resins and of nitrocellulose and cellulose acetate propylene (CAP) base.
- the thickness of temperature and pressure resistant resin is between 0.5 to 10 gsm.
- Inventors principally used combination of nitrocellulose and cellulose acetate propylene based temperature and pressure based resin which offered excellent results towards protecting metal layer from delamination or leaching during the sealing operation..
- Various composition of above combinations can be used, however, the ratio of the composition of nitrocellulose to cellulose acetate propylene (CAP) as 80:20 provided best results which allows operating at high temperature above 210 0 C.
- the thickness of individual layer in the multi-layer laminate can vary depending on specific intended use and also on the ease of operation. Also, the multi-layer laminate may additionally comprise additional layers of polymer, resin or other substances, if desired.
- the novel metallized lidding paper material for blister pack is characterized in that it comprises a paper layer coated with a primer coat, a metal layer, a heat seal lacquer coat and optionally coated with at least one barrier coat on sealing side and an optional color lacquer coat on the other side and a high temperature and pressure resistant lacquer coat applied on the metallized side of the paper.
- the optional lacquer coat is a colored lacquer coat.
- the optional lacquer coat comprises at least one pigment. More preferably, the optional lacquer coat is a colored lacquer coat.
- the thickness of the heat sealing depends on the desired properties. Preferably, the thickness of the heat sealing coat is about 1 to 10 gsm. However, thickness outside this range may also be advantageously employed if desired.
- the novel lidding material according to the present invention is used in the blister packaging of food or pharmaceutical preparations.
- the invention provides a material of a maximum of 45 gsm(40 gsm paper +.27 metal + max 5 gsm print and adhesives) affording a minimum of 22% increase in yield and thus increase in mileage of material. Hence a minimum of 22% increase in units that will be lidded is available, and may reach upto 37% if compared to the higher thickness material.
- Inventors in the present invention have coated the paper material with thin layer of metal by the method of direct metal deposition or by indirect method of deposition (transfer metallization) i.e. MetNova or using metal ink pigment based lacquers i.e. SilNova.
- the metal coating on paper provides a printable opaque, aesthetic material that can be used as a viable option as a lidding material for pharmaceutical blister packaging.
- the quality of printing afforded by paper allows the printing and statutory messages including details about the medication/product to be more clearly read than the glossy print on aluminium. Also the scuff resistance of the material is higher, affording easy readability upto the end of the life cycle of use.
- CAP Cellulose Acetate Propylene
- a process for preparing multilayer metallized paper lidding material by indirect metallization process comprises steps as: a) Release coating and metallization on polyester film; b) Conditioning of the paper at 65% RH and 23 °C for 24 h; c) Lamination of metallized polymeric film with paper; d) Delamination of laminated composite on delamination machine to transfer metal from polyester film and separate out polyester film; e) Applying a barrier coating on the paper; f) Drying the barrier coat; g) Applying heat sealing coating on the side opposite to the metal layer; h) Drying of the heat sealing coat; i) Applying a printing ink layer on outer surface of the metallized paper; j) Drying of the printing layer; and k) Applying temperature and pressure resistant coat on the metallized surface of the metallized paper.
- a typical process for preparing multilayer metallized paper lidding material by direct metallization comprises steps as: a) Conditioning of the paper at 65% RH and 23 0 C for 24 h; b) Applying primer coats on the surface of paper; c) Drying of the primer coat; d) Unwinding paper role on unwinder of the vacuum metallization machine; e) Metallization of the paper by direct metallization process in vacuum metallization chamber; f) Applying a barrier coating on the paper; g) Drying the barrier coat; h) Applying a heat sealing coat on side opposite to metallized side; i) Drying of heat sealing coat; j) Applying a printing ink layer on outer surface of the metallized paper; k) Drying of the printing layer; and
- a process of making metallized paper by process of applying a metal pigment based ink on paper typically comprises the following steps:
- the novel metallized paper lidding materials according to the present invention can be blister packaging of several articles.
- the novel lidding materials according to the present invention can be advantageously used in blister packaging of several articles. Due to high strength and good barrier properties, the lidding materials according to the present invention are particularly suitable for packaging of desired environment sensitive products such as food and pharmaceutical preparations.
- a white super calendared Glassine paper (40 GSM) was kept ready for indirect metallization purpose.
- 23 micron BOPET film was coated with silicon based coating with GSM lesser than 0.1.
- the film roll was then mounted on the unwinder and passed over the series of rollers and brought to the rewinder of the vacuum metallizer.
- the guard over the ceramic evaporation boats and beneath the chilled roll was adjusted to the desired width.
- Aluminium wire of 99.7% purity was fed to the spools and brought to the evaporation boats.
- the chamber was closed and allowed to reach vacuum to the tune of 10 "4 Torr.
- the evaporation boats were heated with the help of A.C. voltage. The temperature was adjusted and maintained at a range sufficient so that the aluminium started evaporating.
- the film was transferred from the unwinder to the rewinder with the help of D. C. drives to the metallization chamber.
- the flapper mounted between the evaporation boats and the chilled drum was removed with the help of remote switch.
- the speed of the machine and the rate of evaporation of the aluminium were adjusted so that an optical density of 3.0 was achieved.
- the aluminium metallization on BOPET film was completed for the desired length under controlled parameters.
- the heating of the ceramic evaporation boat was stopped to stop the metallization process. Air was introduced to remove the vacuum inside the machine.
- the metallized BOPET film roll on the rewinder was taken on the lamination machine and mounted on the unwinder at the rewinder side.
- the paper was mounted on the unwinder roll on the unwinder side.
- 3.0 to 4.0 GSM Poly urethane based adhesive was deposited by the gravure roll process on the paper.
- the ethyl acetate used as carrier was evaporated in the oven between 105 and HO 0 C.
- the dry paper with adhesive was then laminated to the metallized BOPET film by pressing between the two rollers.
- the laminated film was taken to the rewinder to wind the two ply laminate.
- the laminate roll was kept at an ambient temperature for about 24 to 36 hrs.
- the laminate roll was then taken to the delamination machine where the BOPET film was removed and wound on one rewinder and the metallized paper was wound on the other rewinder.
- the metallized paper was then tested for the desired properties and resulted into the following properties:
- An acrylic based primer of thickness 0.5 microns in two pass was coated by gravure coating process on a supercalendered glassine paper roll of 40 gsm using ethyl acetate as a carrier.
- the acrylic based polymer coated glassine paper was then passed through a series of drying oven, mounted and passed over a series of rollers and brought to the rewinder of the vacuum metallizer.
- the guard over the ceramic evaporation boats and beneath the chilled roll was adjusted to the desired width. Aluminium wire of 99.7% purity was fed to the spools and brought to the evaporation boats.
- the chamber was closed and allowed to reach vacuum to the tune of 10 ⁇ Torr.
- the evaporation boats were heated with the help of A.C. voltage.
- the temperature was adjusted in the range sufficient such that the aluminium started evaporating.
- the film was transferred from the unwinder to rewinder with the help of D. C. drives to the metallization chamber.
- the flapper mounted between the evaporation boats and chilled drum was removed with the help of remote switch.
- the speed of the machine and the rate of evaporation of the aluminium were adjusted so that the optical density of 3.0 was achieved.
- the resulting material, after drying had the following properties:
- a metallized lidding material as in example 2 was prepared except that the paper layer used was chromo art paper of thickness 80 gsm. The metallized paper was then tested for the desired properties and resulted into the following properties:
- a metallized lidding paper material was prepared as in example 3, except that the paper layer used was chromo art paper of 80 gsm thickness. The metallized paper was then tested for the desired properties and resulted into the following properties.
- a metallized lidding paper material was prepared as in example 3, except that the paper layer used was wet strength paper of 62 gsm thickness. The metallized paper was then tested for the desired properties and resulted into the following properties.
- a metallized lidding paper material was prepared as in example 2, except that the paper layer used was wet strength paper with thickness 80 gsm. The metallized paper was then tested for the desired properties and the following properties were observed.
- a metallized lidding paper material was prepared as in example 2 and a barrier coat of PVdC 15 micron was applied by gravure coating process on the side opposite to metal layer.
- the resulting multilayered metallized paper lidding material was tested for the desired properties and resulted in to following properties
- a metallized lidding paper material was prepared as in example 3 and a barrier coat of PVdC of thickness 12 gsm was applied by gravure coating process on the side opposite to the metal layer.
- the resulting multilayered metallized paper material was tested for desired properties and the results were as follows:
- a metallized paper lidding material was prepared as in example 8 and a yellow color lacquer of thickness 1.5 microns was applied by gravure coating process. The resulting material was tested for the desired properties and the results were as follows:
- the instant invention offers several technical advancements as mentioned below:
- the instant invention provides a much better ease of manufacture with better resistance to puncture and better scuff resistance, reducing damages during high speed manufacturing processes
- the metallized paper based lidding material in accordance with this invention possesses good barrier property.
- the lidding material can easily be sealed to the blister pack.
- Paper is a better biodegradable product and can be more effectively recycled when compared to aluminium based lidding material.
- the metallized paper based lidding material provided in this invention is cost effective than the existing lidding materials including Aluminum lidding foil. • The metallized paper based lidding material in accordance with this invention is more stable and has significantly lower damages during transit as the paper has much lesser malleability than aluminum.
- the inventors have made an improvement in the sealing machine to avoid leaching of metal by modifying the path of sealing machine by adding an addler in the sealing machine. This improvement reduced the contact time of metallized paper with heater and reduced the probability of leaching out of the metal from paper.
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Abstract
The present invention provides a high temperature and pressure resistant multilayered lidding material for blister packaging.
Description
METALLIZED PAPER BASED LIDDING MATERIAL FOR BLISTER PACKAGING & PROCESS THEREOF
FIELD OF THE INVENTION
The present invention relates to lidding material.
Particularly, the present invention relates to lidding material for blister packaging.
BACKGROUND OF THE INVENTION & PRIOR ART
Blister packing is a common form of packaging used for a wide variety of products such as food articles, pharmaceutical preparations, toys and the like. Blister packing is safe and easy to use and can allow the consumer to see the packaged contents without opening the pack when at least one surface of said blister pack is made of a transparent material such as PVC plastics.
A commonly available blister pack has two surfaces. One surface has cavities at predetermined places to hold the desired article and the other surface acts as a lid. During the process of packaging, the article to be packed is put into the cavity and the lidding material in the form of, for example a foil, is attached or fixed over the open surface of the cavity. To take the article out of the cavity, the lidding material may be burst opened or torn in a suitable fashion to release the article off.
Depending on the specific requirements, a variety of modification of such a conventional blister , packing can be made, especially with respect to the material and the releasing mechanism used to arrive at a suitable blister pack. The most commonly used materials for forming blister are polymer based, such as PVC (polyvinyl chloride) plastics. Depending on the material used and its thickness, such blisters may be transparent, semi- transparent or opaque. Often, polymeric films or aluminium foils are used as lidding materials. One side of the lidding material is also used for printing the product
information and usage instructions. The lidding material is fixed to the surface having cavities through heat sealing mechanism or just by application of adhesive.
Completely paper-based lidding materials are suitable for articles that are insensitive to moisture or surrounding environment, such as plastic toys, batteries and the like. However, purely paper based lidding materials do not have enough strength and barrier properties required for packaging of articles that are sensitive to environment such as food items and pharmaceutical preparations. However, the use of such materials like paper have serious disadvantage that these materials does not provide optimum barrier towards moisture, which is the one of the most essential requirements of the lidding material used in packaging of pharmaceutical products. Such articles are often packed in blisters that use aluminium foil as lidding material due to its higher barrier properties. Such foils can provide adequate moisture or gas barrier, a thin gauge material with eventual printability and desirable push through characteristics. However, such lidding materials also have disadvantages of high cost, the necessity of treatment or surface coating to achieve printability, difficulty in recycling the entire package after use and curling of finished packages.
As discussed above, the use of paper as lidding material in the pharmaceutical product application is limited till date due to stringent packaging requirements. Paper offers very less resistance to the water vapour due its inherent highly porous nature; also it has less tear strength.
To increase the aesthetic appearance of the lidding material, researchers in the field have used many coatings such as coating the paper with Poly vinyl di-chloride (PVdC), or by laminating the paper with PE or PP which increased the barrier property but however, failed to increase the aesthetic appearance of the paper. In other cases, researchers have used pearlized based lacquers, color lacquers and the like which improved the aesthetic appearance of the paper packaging material, however, failed to improve the barrier property of the material.
Also, in many applications the paper is coated with metal pigment based inks or by method of deposition of metal by process of direct metallization or indirect metallization.
More often than not, it is found that during the forming operation of the blister pack with paper based lidding material, problems due to presence of high temperature and pressure are encountered. Due to high temperature and pressure, the metal layer on the lidding material is found to get delaminated from specific areas of the lidding material due to loose anchoring of the metal layer with paper surface. This delamination of metal layer from paper poses serious problems with the package as the aesthetic appearance of the package is threatened.
Another type of lidding material is made from polyamide or polyurethane or PVC. Although such lidding materials solve many of the problems listed above, their primary disadvantage is the difficulty encountered in recycling of the empty blister package.
Economic and environmental reasons require alternative lidding materials that have strength and barrier properties comparable to aluminum foils, but are cheaper than the currently used aluminum foils and can be easily recycled also.
WO 2005/123515 relates to a multilayered material which is peelable and heat-sealable, suitable to bonding with variety of substrates that can be used as a lid on a container, said multilayered material consisting of a solid substrate which is joined to an aliphatic- aromatic co-polyester film. One of the components of aliphatic-aromatic co-polyester film may be biodegradable, and further consists of inorganic fillers of size 0.5 to 10 micrometer and other polymers and copolymers containing butane- 1 polymer and ethylene-vinyl acetate copolymer. Said lidding material can be easily bonded to polystyrene, PP, PE, PVC, PET and PVdC packaging containers. The invention mainly relates to a lidding material for the container for packing contact lenses having saline solution. However, the lidding material prepared in this prior art is meant for easy peelable property.
WO 82/03202 relates to a multilayer metallized paper based material. In this invention, prior to metallization of paper, a layer of thermoplastic resin is extruded above the paper substrate. Thus, the thermoplastic layer is sandwiched between the paper layer and the metal layer. The function of the thermoplastic layer is to aid in the metallization of paper substrate as paper substrate by itself has difficulties in the process metallization. However, this adds to the cost of manufacturing of the metallized paper.
EP Patent Application 0 267 395 relates to preparation of glossy paper material for metallization purpose. The glossy appearance of paper was attainted by laminating an interleaving film and programmed flowable thermoplastic resin material with paper substrate. The programming of flowability of the thermoplastic resin was maintained by applying proper pressure and temperature. During metallization, interleaving film was stripped away to leave glossy thermoplastic resin coated paper substrate for metallization. Metallization of paper can be achieved both by direct and indirect metallization processes. This Patent application necessarily relates to a process to be carried out to get glossy substrate before metallization of the paper substrate. Thus, metallization of paper substrate in the above patent has a layer of glossy thermoplastic resin over paper substrate, which further adds to the cost and complexity of the process.
US Patent 4,434,259 deals with an improved base coating that can be used on the paper substrate which can be further vacuum metallized. The inventors used copolymer of vinyl acetate and acrylic acid in the weight ratio of 97.5-99: 1-2.5 or 94-97 % weight and 3-6% weight of monoethyl maleate. The base coat thus prepared enhances the adhering of metal to the paper substrate and the metallized paper is further used for the decorative purpose or as label for bottles. However, such coated papers are not suitable for use as lidding material for blister packs to be used in pharmaceutical industry.
US Patent 6,086,988 deals with a recyclable lidding material with Polyvinyl Chloride (PVC) bottom in push through packages. The lidding material disclosed in this US Patent uses a rigid PVC base resin with addition of two types of filler materials. These filler materials regulate the frangibility of the lidding material and its vapour barrier
characteristics. One of the filler materials used in this invention is calcium carbonate with irregular particles shape and sizes while second filler material is magnesium silicate hydrate or talc. Function of first filler material is to regulate initiation of tearing in the lidding material while the second material governs the brittleness of lidding material and completion of tearing process. The process disclosed in the aforementioned prior art is a tedious one and is also costly.
US Patent application 3,938,659 relates to a making a sterilized package. The sterilized package is made up of a base paper joined with polymeric closure using heat sealing process. To avoid contamination of paper fibers during peeling of the package to remove satirized product, a blush lacquer is used between the heat seal lacquer and the paper layer. The blush lacquer forms cohesive bond with heat seal lacquer so that when the peeling of the package is done, the peeling process will occur only at the blush lacquer layer and not at the paper layer. This ensures the breaking of bond between blush lacquer and heat seal lacquer and avoid peeling of paper.
US patent application 6254570 relates to method of making a substrate for heat transfer label. Heat transfer labels are used to transfer printing on substrate by heat transfer process. The substrate to be printed is typically a polymer surface where the printing ink is transferred from a carrier to the substrate to be printed. The label is a multilayer material which comprises a carrier substrate which included a support carrier substrate in the form a paper and an adhesive which is UV or EB curable, a transfer release agent in the form a low melting wax and printing ink layer. To carry out transfer of the ink on the substrate, a wax coating acts as a releasing agent that releases the printing ink to the substrate at high temperature.
Various methods disclosed in the prior art are time consuming and complicated. Further, high cost of manufacturing adds to the cost of the final product available to the consumers. Further, difficulty in recycling of the used blister packages is also a matter of concern. Thus, a cheap yet efficient lidding material for blister packaging is the need of the hour.
OBJECTS OF THE INVENTION
One object of the present invention is to provide a lidding material.
Another object of the present invention is to provide a lidding material for blister packaging.
Yet another object of the present invention is to provide a lidding material for blister packaging that is suitable for application in pharmaceutical industries, food industries and the like, particularly for packaging of those commodities which are sensitive to surrounding environment.
Still another object of the present invention is to provide a lidding material which possesses good barrier property against water vapour, moisture and the like.
Still another object of the present invention is to provide a lidding material which is inert in nature and does not alter the properties of the contents packed.
Still another object of the present invention is to provide a lidding material which can easily be sealed to the blister pack and provides good resistance to high temperature and pressure.
Still another object of the present invention is to provide a lidding material which possesses significantly higher push through strength and tearing strength making it more child resistant package and more challenging for children to access the medication from the package.
Still another object of the present invention is to provide a lidding material which is cheaper than the existing lidding materials.
Still another object of the present invention is to provide a lidding material which can easily be recycled besides being aesthetic.
STATEMENT OF THE INVENTION
In accordance with this invention, there is provided a high temperature and pressure resistant multilayered lidding material for packaging of pharmaceutical products, said lidding material comprising: a) a paper layer having a mass per unit area of about 20 to 100 g/m2, said paper layer defined by an operative inner surface facing the product to be packed and an operative outer surface; b) a primer coat applied on said outer surface; c) a metal layer of thickness of about 0.02 to 0.1 microns deposited on said primer coat; d) a high temperature and pressure resistant lacquer coat applied on said metal layer; e) optionally a printing layer applied between said metal layer and said lacquer coat; f) a sealing coat applied on said operative inner surface of said paper; and g) optionally a barrier coat between said paper and sealing coat
to obtain said multilayered lidding material.
Typically, said paper is selected from a group of materials consisting of glassine paper, craft paper, poster paper, map litho paper and sulphated paper.
Typically, in accordance with this invention, said primer is a polymer selected from a group of polymers consisting of nitrocellulose based polymers, acrylic based polymers and polyester based polymers.
Typically, said primer coat has a thickness of about 0.5 to 10 gsm.
Typically, said metal is selected from a group of metals consisting of aluminum, gold, silver, copper, platinum, palladium, tin, and metal alloys viz., brass and bronze.
Typically, said metal layer is deposited by a method selected from a group consisting of a plurality of methods viz., direct vacuum metallization process, indirect metallization process and application of a metallic ink lacquer. ,
Typically, in accordance with this invention, said lacquer coating is a polymeric substance selected from a group of polymers consisting of nitrocellulose, polyester and acrylic based polymers.
Typically, said lacquer coating is mixed with the release lacquer composition for indirect metallization process, applied directly on the metallized side of the paper after direct metallization of the paper or during the printing of the surface.
Typically, said printing layer has a thickness in the range of about 0.5 to 10 gsm.
In a preferred embodiment of the present invention, said printing layer is a coloured layer.
Typically, said coloured layer is obtained by colouring said printing layer with a coloured pigment or coloured lacquer.
Typically, said sealing coat is a polymer coat selected from a group of polymers and copolymers consisting of vinylic polymer, vinylic copolymer, copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
Typically, said sealing coat is a heat sealing coat.
Preferably, said sealing coat has a thickness of about 1 to 10 gsm.
Typically, said barrier coat is a PVdC coat having a thickness in the range of about 5 to 40 gsm.
Typically, said barrier coat is applied by a process selected from a group of processes consisting of gravure coating, reverse gravure coating and doctoring.
In a yet another preferred embodiment of the present invention, there is provided a blister packaging comprising a combination of a polymer blistered laminate and said lidding material.
BRIEF DESCRIPTION OF ACCOMPANYING DRAWINGS
The invention will now be described with the help of following drawing in which:
Fig. 1 illustrates a partial sectional view of a typical lidding material in accordance with the present invention.
DETAILED DESCRIPTION OF THE INVENTION
The inventors of the present invention have comprehensively and successfully investigated the possibility of developing such a highly desired cheaper lidding material and have unexpectedly developed a paper based lidding material for blister pack having excellent strength, barrier properties and look like aluminium foil which provide an opaque surface for printing and are cheaper than aluminium foils. They provide good resistance towards high temperature and pressure.
Further, the inventors of this invention have come up with a paper based lidding material which is aesthetically appealing, provides a printable surface with opacity of more than 90% for proper legibility of printed matter. Further, the paper and the printed matter are
able to withstand high temperature and pressure during the sealing as well as printing operations and also withstand possible abrasions during transit.
The present invention provides a high temperature and pressure resistant multilayered lidding material for packaging of pharmaceutical products generally indicated by reference numeral 100 as shown in Fig. 1, said lidding material comprising:
a) a paper layer (10) having a mass per unit area of about 20 to 100 g/m2, said paper layer defined by an operative inner surface facing the product to be packed and an operative outer surface; b) a primer coat applied on said outer surface; c) a metal layer (12) of thickness of about 0.02 to 0.1 microns deposited on said primer coat; d) a high temperature and pressure resistant lacquer (14) coat applied on said metal layer; e) optionally a printing layer applied between said metal layer and said lacquer coat; f) a sealing coat (18) applied on said operative inner surface of said paper; and g) optionally a barrier coat (16) between said paper and sealing coat
to obtain said multilayered lidding material.
The term "pharmaceutical product" as mentioned in the specification refers to various types of drugs including food and nutritional supplements.
The term "paper" as mentioned in the specification refers to a sheet of paper having one or more stratum of paper.
The term "coating" as used in the present text includes applying, layering and pressing or deposition of metal by vacuum evaporation process or by indirect metallization process or by using metallic ink pigment.
Various types of paper suitable for the preparation of high temperature and pressure resistant multilayered lidding material in accordance with this invention include glassine paper, craft paper, poster paper, map litho paper and sulphated paper.
Typically, the primer used for coating the operative outer surface of the paper is a polymer. Nitrocellulose based polymers, acrylic based polymers and polyester based polymers are some examples of such polymers suitable for primer coating.
Typically, the primer coat has a thickness of about 0.5 to 10 gsm.
The paper can be metallized with different types of metals like aluminum, gold, silver, copper, platinum, palladium, tin, etc. Further, metal alloys like brass and bronze may also be used for metallization of the paper.
The metal layer may be deposited by any suitable methods known in the prior art such as direct vacuum metallization process, indirect metallization process and application of metallic ink lacquer/pigment.
A high temperature and pressure resistant lacquer coat of a polymeric substance is applied on to the metal layer, which is of utmost importance during the formation of blister packages since blister packaging involves employment of high temperatures and pressure at various stages of development of the package. Generally, the lacquer coat of the polymeric substance is a resinous material like nitrocellulose, polyester and acrylic based polymers.
The method used for coating the lacquer on the metallized paper may vary depending on the type of metallization method used. For example, the lacquer coating is mixed with the release lacquer composition for Indirect metallization process, whereas the lacquer coating is applied directly on the metallized side of the paper after Direct metallization of the paper. Further, the lacquer coating can also be applied during the printing of the surface.
Printing of the information pertaining to the contents of the package is of utmost importance for the manufacturers as well as the consumers. In this regard, a good printing layer is necessary for any blister packaging system. A. printing layer of a thickness of about 0.5 to 10 gsm is found to be optimum for this purpose.
Inorder to enhance the aesthetic appearance of the blister package, the printing layer is preferably chosen to be a coloured layer. This can be achieved by colouring the printing layer with a coloured pigment or a coloured lacquer.
The final sealing of the lidding material to the blister pack containing the pharmaceutical products is one of the most important steps during blister packaging. Such sealing should be air-tight inorder to preserve the contents of the package. The sealing coat used in this invention is a polymer coat like vinylic polymer, vinylic copolymer, copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
Typically, the sealing coat is a heat sealing coat and has a thickness of about 1 to 10 gsm.
A barrier coat between the paper and the sealing coat is optional. However, it is advisable to provide at least one such barrier coat in order to increase the strength of the paper and its shielding capacity against water vapour, gases and other material which will influence the activity of the pharmaceutical or food product. A polyvinyl dichloride layer (PVdC) coat having a thickness in the range of about 5 to 40 gsm is found to be a good choice for such as barrier.
The barrier coat may be applied by any process known to a person skilled in the art like gravure coating, reverse gravure coating and doctoring.
In still another preferred embodiment of the present invention, there is provided a blister packaging comprising a combination of a polymer blistered laminate and said lidding material.
Accordingly, this invention provides a multilayered lidding material for blister packaging comprising a paper layer having first operative layer (facing the cavity or inner surface) coated with optional barrier layer and sealing layer while, second surface (facing opposite to the cavity or outer surface) coated with metallized layer by a method of indirect metallization process or direct vacuum metallization process. Further, the metallized paper is optionally coated with lacquer layer for obtaining printable surface. Thus, the lidding material according to this invention comprises a paper layer sandwiched between a barrier coat and sealing coat on one side and a metal layer and an optional lacquer coat suitable for printing on the other side.
As discussed above, the present invention provides a lidding material for blister pack comprising a paper layer coated with a primer coat, metal layer, a temperature resistant lacquer coat, a heat seal lacquer coat and optionally coated with at least one barrier coat on sealing side of the paper prior to heat seal lacquer coat, a color lacquer coat on metallized side.
A wide variety of paper can be used. Typically, the paper layer comprises at least one paper selected from a group consisting of glassine paper, craft paper, yellow parchmentine paper, tracing paper, super calendared paper, poster paper, chromed paper, white super calendared glassine paper, red super calendared glassine paper and white poster paper. The thickness of the paper layer depends on the desired properties. Preferably, the thickness of the paper layer is about 25 to 100 gsm. However, thickness outside this range may also be advantageously employed if desired.
Lidding material is essential part of blister packaging. The lidding part provides the Hd to the product enclosed in the cavity of packaging as well as it also provides barrier against water vapour, gases and other material which will influence the activity of the pharmaceutical or food product. As the lidding material in this invention is used for the packaging of pharmaceutical product therefore, it is utmost important that the material used should be biocompatible and the does not release any hazardous constituents during the storage of the product. To pass the biocompatibility, paper and polymeric materials
are generally used. However, the lidding material should also provide enough strength and easy tearing property so that user or consumer can easily have access to the packaged product. Many polymeric laminates and aluminum foils are used for the lidding application but had some or other problems and these laminates are not cheap, so people mainly prefer to use paper as lidding material. However, paper has it's own disadvantages such as it is porous in nature which restricts the use of paper as lidding material in pharmaceutical product packaging as water vapour and other gases can easily pass through the paper which deteriorates the pharmaceutical product. Also, it can be easily attacked by acid and alkali atmosphere.
Many processes are carried out to overcome these problems with paper, of which one is to coat the paper with waxy organic layer to make it hydrophobic and to reduce the porous nature of paper. However, as paper is porous in nature, to get a uniform coating of organic layer lot of efforts and materials have to be consumed. Other way is to make a multilayered paper laminate in which one of the layer is polymeric layer.
The inventors in the present invention have come out with a new paper based lidding material in which a metal layer is deposited or provided on one side of the paper lidding material. Here, the inventors have prepared a paper based lidding material without the use of any polymeric film.
A metallized paper based lidding material can be prepared by coating the paper by a metal pigment nitrocellulose based ink. The metal ink provides a matte finish to paper. Further, it also improves the opacity of the paper and provides an opaque printable surface. Generally, the opacity of paper is required to be above 90%. To achieve this opacity, the percentage of metal pigment in ink is between 15 to 17%. Below this percentage the opacity of the paper will be low and above which the uniform layer of metal ink will not be obtained and can give printing problems such as mottling effect. Therefore, the optimum working range of the ink is 15 to 17%. The base of the ink is nitrocellulose resin which is around 10 to 12%, and it has temperature and pressure resistant property. A silicon oil based slip additive is mixed with the ink. This slip
additive ensures the uniform spreading of ink on the paper surface, usually intermolecular friction is present in the pigment. This friction leads to nonuniform layer formation of metal ink on the surface, however, when slip additives are added to ink, the slip additive reduces the friction and forms a uniform layer of ink. Amount more than 0.05% of slip additive will pose a difficulty in printing operation. Above this metal ink layer, a printing ink lacquer is applied by the known method of gravure coating process. However, during the sealing operation, the printing ink is usually unable to withstand the sealing temperature and is leached out from the metal surface. To avoid this, an overcoat of nitrocellulose based lacquer of thickness between 0.5 to 10 GSM is applied.
Metallization of the paper lidding material was carried out by two different methods like direct metallization and indirect metallization. In the direct metallization process, a metal layer was directly deposited on paper lidding material while in case of indirect metallization, the metallization of paper was carried out by transferring a metal layer from metallized biaxially oriented polyethylene terphthalate film. ,
Prior to metallization, a specially developed primer coat was applied on the paper. The primer coat imparts adhesion of the metal layer on paper uniformly and ensures strong adhesion of the metal layer on the paper even after the processing for sealing with polymeric blisters. Further, it improves the glossy appearance of the metallized paper. Special nitrocellulose based primer coat was developed for direct metallization process and thickness of the primer coat was between 0.5 to lOgsm.
Vacuum metallization is a process in which an ulra-thin layer of metal deposited on a substrate such as plastic, glass, paper and the like to achieve a metallic surface appearance. Metallizing directly on paper however results in a totally unacceptable material, i.e. paper with dull surface. This is due to the rough texture of paper surface. Since the deposited metal adheres directly to the surface of the substrate being metallized and also since the resulting metal coating thickness is about 250 to 300 A, the direct deposition of metal on paper yields an unacceptable product. Hence the surface of paper is typically coated with a base coating can be called as a 'primer coat' which fills minor
surface imperfections and provides smooth surface to receive metal deposition. Among the properties which are important in base coat or primer coat are adhesion, water resistance and block resistance.
In the present invention, the metal is deposited on paper substrate by two different processes such as direct metallization and indirect metallization and surprisingly the inventors found that the two metallization processes imparted different metallic appearances to the paper substrate and this may be due a role played by primer coat used. In present invention, the inventor used nitrocellulose based base coat in both the types of metal deposition process.
Indirect metallization process of paper based lidding paper material is carried out by lamination and delamination process. Initially bi-axially oriented polyester film is coated with release coat of silicon based material, followed by metallization of desired thickness. Subsequently, this metallized film is laminated with paper substrate to be metallized and polyester film is separated from paper substrate by delamination method. This delamination process ensures transfer of metal from polyester film to the paper substrate. Also, as the surface of the oriented polymeric film is very smooth, this enhances the gloss of the metallized paper.
The barrier coat imparts barrier properties to the lidding material. Typically, the barrier coat comprises at least one polymer. Preferably, the barrier coat comprises PVdC. The thickness of the barrier coat depends on the desired barrier properties. Preferably, the thickness of the barrier coat is about 5 to 40 gsm. However, thickness outside this range may also be advantageously employed if desired.
The heat sealing coat is useful in sealing the lidding material with the base material of the blister. Typically, the heat sealing coat comprises at least one vinylic polymer or a vinylic copolymer. Preferably, the heat sealing coat comprises at least one material selected from a group consisting of copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
The inventors have also modified the path of the sealing machine by adding "an addler" in the path of the heater and the paper roll unwinder. This addition ensures short contact time of metallized paper with heater. The path is so modified that, the sealing time is sufficient to seal the metallized paper lidding material with polymeric blister at the same time avoid the de-lamination of metal from paper surface due to presence of high temperature.
The thickness of the heat sealing depends on the desired sealing properties. Preferably, the thickness of the heat sealing coat is about 1 to 10 gsm. However, thickness outside this range may also be advantageously employed if desired. It is found that during sealing operation, temperature of sealing heater is above 200° C which results in delamination of metal from the paper surface. The inventors found that the thickness of the sealing coat decides the stability of metal layer. Generally thickness of the sealing coat is ~ 5 GSM, however, at this thickness, the metal layer leached out. Therefore, inventors varied the thickness of sealing coat from 5 GSM up to 10 GSM. At 6 GSM thicknesses, there was no improvement in the performance of the paper and at 7 GSM, excellent results were obtained where the metal layer remained on the paper i.e., the amount of metal delamination was minimum. For thickness above 7 GSM, it was found that operating temperature of sealing machine has to be increased above 210°C to obtain sealing, which is not advisable. At this temperature, the metal starts leaching out and further, the paper cannot withstand this temperature. At a thickness of 7 GSM, it is observed that the amount of heat transferred from the heating plate to the paper is lesser when compared to the amount of heat transferred at the thickness of 5 or 6 GSM.
During the forming process, the material is exposed to high temperature and pressure. Due to high temperature and pressure and the basic property of paper, the metal layer present on the paper easily get delaminated from paper surfaces which leads to unwanted removal of metal and loss of aesthetic appearance of lidding material. Therefore, it is desirable to use a temperature and pressure resistant lacquer on metal layer. Application of temperature and pressure resistant lacquer on the metallized paper can be achieved either by directly coating the lacquer layer on metal by known processes such gravure
coating process or adding temperature and pressure resistant resins in the release lacquer which is used in indirect metallization process. In the Indirect metallization process, the release lacquer comprises of silicon based lacquer which is mixed with temperature and pressure resistant resins. These resins specifically transferred on the metal surface during indirect metallization process. Thus in any case temperature and pressure resistant resin protects the metal from delamination. Temperature and pressure resins comprise resins from a group of resins selected from nitrocellulose based resins, acrylic and polyester based resins and of nitrocellulose and cellulose acetate propylene (CAP) base. The thickness of temperature and pressure resistant resin is between 0.5 to 10 gsm. Inventors principally used combination of nitrocellulose and cellulose acetate propylene based temperature and pressure based resin which offered excellent results towards protecting metal layer from delamination or leaching during the sealing operation.. Various composition of above combinations can be used, however, the ratio of the composition of nitrocellulose to cellulose acetate propylene (CAP) as 80:20 provided best results which allows operating at high temperature above 2100C.
The thickness of individual layer in the multi-layer laminate can vary depending on specific intended use and also on the ease of operation. Also, the multi-layer laminate may additionally comprise additional layers of polymer, resin or other substances, if desired.
The novel metallized lidding paper material for blister pack is characterized in that it comprises a paper layer coated with a primer coat, a metal layer, a heat seal lacquer coat and optionally coated with at least one barrier coat on sealing side and an optional color lacquer coat on the other side and a high temperature and pressure resistant lacquer coat applied on the metallized side of the paper. Typically, the optional lacquer coat is a colored lacquer coat. Preferably, the optional lacquer coat comprises at least one pigment. More preferably, the optional lacquer coat is a colored lacquer coat.
The thickness of the heat sealing depends on the desired properties. Preferably, the thickness of the heat sealing coat is about 1 to 10 gsm. However, thickness outside this range may also be advantageously employed if desired.
Preferably, the novel lidding material according to the present invention is used in the blister packaging of food or pharmaceutical preparations.
SilNova:
• Use of metallic pigment based nitrocellulose inks in which metal % is between 15-17 %
• Use of slip additives in the % of 0.05 which will ensure the formation of uniform layer of metal ink on paper.
The invention provides a material of a maximum of 45 gsm(40 gsm paper +.27 metal + max 5 gsm print and adhesives) affording a minimum of 22% increase in yield and thus increase in mileage of material. Hence a minimum of 22% increase in units that will be lidded is available, and may reach upto 37% if compared to the higher thickness material.
Inventors in the present invention have coated the paper material with thin layer of metal by the method of direct metal deposition or by indirect method of deposition (transfer metallization) i.e. MetNova or using metal ink pigment based lacquers i.e. SilNova. The metal coating on paper provides a printable opaque, aesthetic material that can be used as a viable option as a lidding material for pharmaceutical blister packaging.
However, it was found that the metal layer that is deposited on the paper can not withstand the temperature of sealing and printing, it got delaminated from paper surface. The reason for de-lamination is the weakening of the physical bond between the metal layer and the paper at the time of sealing and printing operation due to presence of high temperature. Therefore, inventors used high temperature and pressure resistant lacquers as a coating on the metal layer as well as on printing layer to protect them from de- lamination. High temperature and pressure lacquers which are normally nitrocellulose
base, or polyester or acrylic base material can be used in transfer resin material as one of the constituents which will specifically get transferred on the metal layer during transfer (indirect) metallization process, or it can be applied directly as a coating on the metal layer after direct metallization process.
The quality of printing afforded by paper allows the printing and statutory messages including details about the medication/product to be more clearly read than the glossy print on aluminium. Also the scuff resistance of the material is higher, affording easy readability upto the end of the life cycle of use.
Further, as discussed earlier, the inventors have used modified nitrocellulose temperature and pressure resin in which inventors have added Cellulose Acetate Propylene (CAP) in specific ratios. Use of CAP has improved the temperature and pressure resistance capacity of nitrocellulose.
In SilNova, the inventors have used a slip additive in the nitrocellulose based metal ink which will ensure the formation of uniform layer of metal ink on the paper surface. Metal ink will provide a matt finish to paper.
Typically, a process for preparing multilayer metallized paper lidding material by indirect metallization process comprises steps as: a) Release coating and metallization on polyester film; b) Conditioning of the paper at 65% RH and 23 °C for 24 h; c) Lamination of metallized polymeric film with paper; d) Delamination of laminated composite on delamination machine to transfer metal from polyester film and separate out polyester film; e) Applying a barrier coating on the paper; f) Drying the barrier coat; g) Applying heat sealing coating on the side opposite to the metal layer; h) Drying of the heat sealing coat; i) Applying a printing ink layer on outer surface of the metallized paper;
j) Drying of the printing layer; and k) Applying temperature and pressure resistant coat on the metallized surface of the metallized paper.
Further, a typical process for preparing multilayer metallized paper lidding material by direct metallization comprises steps as: a) Conditioning of the paper at 65% RH and 23 0C for 24 h; b) Applying primer coats on the surface of paper; c) Drying of the primer coat; d) Unwinding paper role on unwinder of the vacuum metallization machine; e) Metallization of the paper by direct metallization process in vacuum metallization chamber; f) Applying a barrier coating on the paper; g) Drying the barrier coat; h) Applying a heat sealing coat on side opposite to metallized side; i) Drying of heat sealing coat; j) Applying a printing ink layer on outer surface of the metallized paper; k) Drying of the printing layer; and
1) Applying temperature and pressure resistant resin coat on the inner surface of the metallized paper.
Further, a process of making metallized paper by process of applying a metal pigment based ink on paper typically comprises the following steps:
a) Conditioning of the paper at 65% RH at 23° C for 24 hours; b) Applying a metal pigment based ink lacquer of thickness between 0.5 to 5 Gsm on paper by known coating process like gravure coating process; c) Drying of the metallic pigment based ink lacquer coat; d) Applying a printing lacquer coat of thickness between 0.5 to 5 Gsm is applied over metallic ink lacquer coat; e) Drying of printing ink lacquer coat;
f) Applying a temperature and pressure resistant lacquer over coat on printing ink lacquer coat; g) Drying temperature and pressure based lacquer coat; h) Applying a barrier coat on the side opposite to the metal ink layer; i) Drying of the barrier coat; and j) Applying heat seal lacquer coat on barrier coat.
The novel metallized paper lidding materials according to the present invention can be blister packaging of several articles. Typically, the novel lidding materials according to the present invention can be advantageously used in blister packaging of several articles. Due to high strength and good barrier properties, the lidding materials according to the present invention are particularly suitable for packaging of desired environment sensitive products such as food and pharmaceutical preparations.
The invention is further elaborated with the help of following examples; however, these examples should not be construed to limit the scope of the present invention.
EXAMPLE 1
An aluminium hard tempered foil (20 micron thickness) was first coated with PVdC - Diofan 736@ barrier coat to achieve a barrier coating thickness of 12 GSM with the help of Air Knife coating process (at an air pressure of 30-50 bar, speed of coating being 50m/min. and at oven temperature of 1150C. The specific gravity of barrier dispersion solution was between 1.1-1.6). The resulting material, after drying had the following properties:
• Average WVTR @38D.C. and 90% RH: 0 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 1.4 Kg
• WVTR for 0 size blister - 9.1 g/m2/day
EXAMPLE 2
A white super calendared Glassine paper (40 GSM) was kept ready for indirect metallization purpose. 23 micron BOPET film was coated with silicon based coating with GSM lesser than 0.1. The film roll was then mounted on the unwinder and passed over the series of rollers and brought to the rewinder of the vacuum metallizer. The guard over the ceramic evaporation boats and beneath the chilled roll was adjusted to the desired width. Aluminium wire of 99.7% purity was fed to the spools and brought to the evaporation boats. The chamber was closed and allowed to reach vacuum to the tune of 10"4 Torr. The evaporation boats were heated with the help of A.C. voltage. The temperature was adjusted and maintained at a range sufficient so that the aluminium started evaporating. At the same time, the film was transferred from the unwinder to the rewinder with the help of D. C. drives to the metallization chamber. After the stabilization of the vacuum and uniform heating of the evaporation boats, the flapper mounted between the evaporation boats and the chilled drum was removed with the help of remote switch. The speed of the machine and the rate of evaporation of the aluminium were adjusted so that an optical density of 3.0 was achieved. The aluminium metallization on BOPET film was completed for the desired length under controlled parameters. The heating of the ceramic evaporation boat was stopped to stop the metallization process. Air was introduced to remove the vacuum inside the machine. The metallized BOPET film roll on the rewinder was taken on the lamination machine and mounted on the unwinder at the rewinder side. The paper was mounted on the unwinder roll on the unwinder side. 3.0 to 4.0 GSM Poly urethane based adhesive was deposited by the gravure roll process on the paper. The ethyl acetate used as carrier was evaporated in the oven between 105 and HO0C. The dry paper with adhesive was then laminated to the metallized BOPET film by pressing between the two rollers. The laminated film was taken to the rewinder to wind the two ply laminate.
The laminate roll was kept at an ambient temperature for about 24 to 36 hrs. The laminate roll was then taken to the delamination machine where the BOPET film was removed and wound on one rewinder and the metallized paper was wound on the other rewinder.
The metallized paper was then tested for the desired properties and resulted into the following properties:
• Average WVTR @38D.C. and 90% RH: 50g/m2/day
• Opacity -100%
• Sealing Strength— 0.2 Kg/cm(With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 3
An acrylic based primer of thickness 0.5 microns in two pass was coated by gravure coating process on a supercalendered glassine paper roll of 40 gsm using ethyl acetate as a carrier. The acrylic based polymer coated glassine paper was then passed through a series of drying oven, mounted and passed over a series of rollers and brought to the rewinder of the vacuum metallizer. The guard over the ceramic evaporation boats and beneath the chilled roll was adjusted to the desired width. Aluminium wire of 99.7% purity was fed to the spools and brought to the evaporation boats. The chamber was closed and allowed to reach vacuum to the tune of 10 ^ Torr. The evaporation boats were heated with the help of A.C. voltage. The temperature was adjusted in the range sufficient such that the aluminium started evaporating. At the same time, the film was transferred from the unwinder to rewinder with the help of D. C. drives to the metallization chamber. After the stabilization of the vacuum and uniform heating of the evaporation boats, the flapper mounted between the evaporation boats and chilled drum was removed with the help of remote switch. The speed of the machine and the rate of evaporation of the aluminium were adjusted so that the optical density of 3.0 was achieved. The resulting material, after drying had the following properties:
• Average WVTR @ 38D.C. and 90% RH: 50 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 4
A metallized lidding material as in example 2 was prepared except that the paper layer used was chromo art paper of thickness 80 gsm. The metallized paper was then tested for the desired properties and resulted into the following properties:
• Average WVTR @ 38D.C. and 90% RH: 50 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm(With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 5
A metallized lidding paper material was prepared as in example 3, except that the paper layer used was chromo art paper of 80 gsm thickness. The metallized paper was then tested for the desired properties and resulted into the following properties.
• Average WVTR @38D.C. and 90% RH: 50 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 6
A metallized lidding paper material was prepared as in example 3, except that the paper layer used was wet strength paper of 62 gsm thickness. The metallized paper was then tested for the desired properties and resulted into the following properties.
• Average WVTR @ 38D.C. and 90% RH: 50 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.95 Kg
EXAMPLE 7
A metallized lidding paper material was prepared as in example 2, except that the paper layer used was wet strength paper with thickness 80 gsm. The metallized paper was then tested for the desired properties and the following properties were observed.
• Average WVTR @38D.C. and90% RH: 50 g/ni2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 8
A metallized lidding paper material was prepared as in example 2 and a barrier coat of PVdC 15 micron was applied by gravure coating process on the side opposite to metal layer. The resulting multilayered metallized paper lidding material was tested for the desired properties and resulted in to following properties
• Average WVTR @ 38D.C. and 90% RH: 12 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 9
A metallized lidding paper material was prepared as in example 3 and a barrier coat of PVdC of thickness 12 gsm was applied by gravure coating process on the side opposite to the metal layer. The resulting multilayered metallized paper material was tested for desired properties and the results were as follows:
• Average WVTR @ 38D.C. and 90% RH: 19g/m2/day
• Opacity -100%
• Sealing^Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.8 Kg
EXAMPLE 10
A metallized paper lidding material was prepared as in example 8 and a yellow color lacquer of thickness 1.5 microns was applied by gravure coating process. The resulting material was tested for the desired properties and the results were as follows:
• Average WVTR @ 38D.C. and 90% RH: 12 g/m2/day
• Opacity -100%
• Sealing Strength - 0.2 Kg/cm (With PVC film)
• Push through force for blister - 2.8 Kg
TECHNICAL ADVANCEMENTS & ECONOMIC SIGNIFICANCE
The instant invention offers several technical advancements as mentioned below:
• The instant invention provides a much better ease of manufacture with better resistance to puncture and better scuff resistance, reducing damages during high speed manufacturing processes
• The metallized paper based lidding material in accordance with this invention possesses good barrier property.
• The lidding material can easily be sealed to the blister pack.
• It has significantly better readability due to lower reflectability.
• It offers significantly higher push through strength and tearing strength making it more child resistant package and more challenging for children to access the medication from the package.
• Paper is a better biodegradable product and can be more effectively recycled when compared to aluminium based lidding material.
• The metallized paper based lidding material provided in this invention is cost effective than the existing lidding materials including Aluminum lidding foil.
• The metallized paper based lidding material in accordance with this invention is more stable and has significantly lower damages during transit as the paper has much lesser malleability than aluminum.
• Use of high temperature and pressure resistant nitrocellulose base lacquer with modification i.e., use of Cellulose acetate Propylene (CAP) in the specified ratios increases the temperature and pressure resistance of the lidding material.
• The change in thickness of the heat seal lacquer form 5 GSM to 7 GSM results in lesser amount of heat transferred from the heater to the lidding material.
• Also, the inventors have made an improvement in the sealing machine to avoid leaching of metal by modifying the path of sealing machine by adding an addler in the sealing machine. This improvement reduced the contact time of metallized paper with heater and reduced the probability of leaching out of the metal from paper.
Claims
1. A high temperature and pressure resistant multilayered lidding material for packaging of pharmaceutical products, said lidding material comprising: a) a paper layer having a mass per unit area of about 20 to 100 g/m2, said paper layer defined by an operative inner surface facing the product to be packed and an operative outer surface; b) a primer coat applied on said outer surface; c) a metal layer of thickness of about 0.02 to 0.1 microns deposited on said primer coat; d) a high temperature and pressure resistant lacquer coat applied on said metal layer; e) optionally a printing layer applied between said metal layer and said lacquer coat; f) a sealing coat applied on said operative inner surface of said paper; and g) optionally a barrier coat between said paper and sealing coat
to obtain said multilayered lidding material.
2. The multilayered lidding material as claimed in Claim 1, wherein said paper is selected from a group of materials consisting of glassine paper, craft paper, poster paper, map litho paper and sulphated paper.
3. The multilayered lidding material as claimed in Claim 1, wherein said primer is a polymer selected from a group of polymers consisting of nitrocellulose based polymers, acrylic based polymers and polyester based polymers.
4. The multilayered lidding material as claimed in Claim 1, wherein said primer coat has a thickness of about 0.5 to 10 gsm.
5. The multilayered lidding material as claimed in Claim 1, wherein said metal is selected from a group of metals consisting of aluminum, gold, silver, copper, platinum, palladium, tin, and metal alloys viz., brass and bronze.
6. The multilayered lidding material as claimed in Claim 1, wherein said metal layer is deposited by a method selected from a group consisting of a plurality of methods viz., direct vacuum metallization process, indirect metallization process and application of a metallic ink lacquer.
7. The multilayered lidding material as claimed in Claim 1, wherein said lacquer coating is a polymeric substance selected from a group of polymers consisting of nitrocellulose, polyester and acrylic based polymers.
8. The multilayered lidding material as claimed in Claim 1, wherein said lacquer coating is mixed with the release lacquer composition for indirect metallization process, applied directly on the metallized side of the paper after direct metallization of the paper or during the printing of the surface.
9. The multilayered lidding material as claimed in Claim 1, wherein said printing layer has a thickness in the range of about 0.5 to 10 gsm.
10. The multilayered lidding material as claimed in Claim 1, wherein said printing layer is a coloured layer.
11. The multilayered lidding material as claimed in Claim 10 wherein said coloured layer is obtained by colouring said printing layer with a coloured pigment or coloured lacquer.
12. The multilayered lidding material as claimed in Claim 1, wherein said sealing coat is a polymer coat selected from a group of polymers and co-polymers consisting of vinylic polymer, vinylic copolymer, copolymer of vinylchloride- vinyl acetate and butyl methacrylate.
13. The multilayered lidding material as claimed in Claim 1, wherein said sealing coat is a heat sealing coat.
14. The multilayered lidding material as claimed in Claim 1, wherein said sealing coat has a thickness of about 1 to 10 gsm.
15. The multilayered lidding material as claimed in Claim 1, wherein said barrier coat is a PVdC coat having a thickness in the range of about 5 to 40 gsm.
16. The multilayered lidding material as claimed in Claim 1, wherein said barrier coat is applied by a process selected from a group of processes consisting of gravure coating, reverse gravure coating and doctoring.
17. A blister packaging comprising a combination of a polymer blistered laminate and said lidding material in accordance with any one of the Claims 1 to 16.
18. The high temperature and pressure resistant multilayered lidding material and the blister packaging as substantially herein described with reference to examples and drawing.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN595/MUM/2008 | 2008-03-24 | ||
| IN595MU2008 | 2008-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009118761A2 true WO2009118761A2 (en) | 2009-10-01 |
| WO2009118761A3 WO2009118761A3 (en) | 2011-08-11 |
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ID=41114418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2009/000196 WO2009118761A2 (en) | 2008-03-24 | 2009-03-24 | Metallized paper based lidding material for blister packaging & process thereof |
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| Country | Link |
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| WO (1) | WO2009118761A2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015050438A1 (en) * | 2013-10-01 | 2015-04-09 | Coldenhove Know How B.V. | Lidding material for blister packaging and the like |
| JP2016002706A (en) * | 2014-06-17 | 2016-01-12 | 凸版印刷株式会社 | Packaging material and packaging container using the same as lid material |
| US9416495B2 (en) | 2009-12-23 | 2016-08-16 | Arjo Wiggins Fine Papers Limited | Printable sheet that is ultra-smooth and recyclable, and its method of fabrication |
| US9648751B2 (en) | 2012-01-13 | 2017-05-09 | Arjo Wiggins Fine Papers Limited | Method for producing a sheet |
| IT201700033470A1 (en) * | 2017-03-27 | 2018-09-27 | Adercarta S P A | ANTIBACTERIAL FOOD PACKAGE |
| CN116676814A (en) * | 2023-06-07 | 2023-09-01 | 安姆科科技研发有限公司 | High-barrier degradable paper package and preparation method thereof |
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| US6537680B1 (en) * | 1998-09-03 | 2003-03-25 | Stora Kopparbergs Bergslags Aktiebolag (Publ) | Paper or paperboard laminate and method to produce such a laminate |
| WO2004093883A2 (en) * | 2003-04-23 | 2004-11-04 | Ferring B.V. | Sachet for a pharmaceutical composition |
| JP2006142597A (en) * | 2004-11-18 | 2006-06-08 | Toppan Printing Co Ltd | Packaging laminate, packaging bag using it and package using packaging bag |
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| US4360550A (en) * | 1979-09-12 | 1982-11-23 | Toyo Kagaku Kabushiki Kaisha | Composite packing film and packing bag made of the same |
| US4340141A (en) * | 1981-02-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | Unit dose drug control package |
| US6537680B1 (en) * | 1998-09-03 | 2003-03-25 | Stora Kopparbergs Bergslags Aktiebolag (Publ) | Paper or paperboard laminate and method to produce such a laminate |
| WO2004093883A2 (en) * | 2003-04-23 | 2004-11-04 | Ferring B.V. | Sachet for a pharmaceutical composition |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9416495B2 (en) | 2009-12-23 | 2016-08-16 | Arjo Wiggins Fine Papers Limited | Printable sheet that is ultra-smooth and recyclable, and its method of fabrication |
| US9648751B2 (en) | 2012-01-13 | 2017-05-09 | Arjo Wiggins Fine Papers Limited | Method for producing a sheet |
| WO2015050438A1 (en) * | 2013-10-01 | 2015-04-09 | Coldenhove Know How B.V. | Lidding material for blister packaging and the like |
| US9487918B2 (en) | 2013-10-01 | 2016-11-08 | Coldenhove Know How B.V. | Lidding material for blister packaging and the like |
| CN106414846A (en) * | 2013-10-01 | 2017-02-15 | 科尔登霍夫路浩有限公司 | Lidding material for blister packaging and the like |
| JP2016002706A (en) * | 2014-06-17 | 2016-01-12 | 凸版印刷株式会社 | Packaging material and packaging container using the same as lid material |
| IT201700033470A1 (en) * | 2017-03-27 | 2018-09-27 | Adercarta S P A | ANTIBACTERIAL FOOD PACKAGE |
| CN116676814A (en) * | 2023-06-07 | 2023-09-01 | 安姆科科技研发有限公司 | High-barrier degradable paper package and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009118761A3 (en) | 2011-08-11 |
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