WO2009111476A3 - Assay for systematic lupus erthematosus - Google Patents

Assay for systematic lupus erthematosus Download PDF

Info

Publication number
WO2009111476A3
WO2009111476A3 PCT/US2009/035882 US2009035882W WO2009111476A3 WO 2009111476 A3 WO2009111476 A3 WO 2009111476A3 US 2009035882 W US2009035882 W US 2009035882W WO 2009111476 A3 WO2009111476 A3 WO 2009111476A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
nucleic acid
assay
formation
immunoreaction
Prior art date
Application number
PCT/US2009/035882
Other languages
French (fr)
Other versions
WO2009111476A2 (en
Inventor
Charles A. Kallick
Original Assignee
Sphingomonas Research Partners, L.P.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sphingomonas Research Partners, L.P. filed Critical Sphingomonas Research Partners, L.P.
Publication of WO2009111476A2 publication Critical patent/WO2009111476A2/en
Publication of WO2009111476A3 publication Critical patent/WO2009111476A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

An assay for the presence of systemic lupus erythematosus (SLE) is disclosed. In one aspect, a specific a specific bacterial nucleic acid sequence of one or more of SEQ ID NOs: 1-9 is admixed with an analyte from the human to be diagnosed and the presence or absence of nucleic acid hybrid formation is determined. In another embodiment, antibodies from the human to be diagnosed are admixed with a promyelocyte Ehrlichiae Ep group antigen to form an antigen/antibody admixture that is maintained for a time period sufficient for immunoreaction and formation of an immunoreaction product, and the presence or absence of the immunoreaction product is determined. In each respective instance, nucleic acid hybrid formation or immunoreaction product formation indicates that the human has SLE.
PCT/US2009/035882 2008-03-03 2009-03-03 Assay for systematic lupus erthematosus WO2009111476A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3325308P 2008-03-03 2008-03-03
US61/033,253 2008-03-03

Publications (2)

Publication Number Publication Date
WO2009111476A2 WO2009111476A2 (en) 2009-09-11
WO2009111476A3 true WO2009111476A3 (en) 2009-12-30

Family

ID=41056606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/035882 WO2009111476A2 (en) 2008-03-03 2009-03-03 Assay for systematic lupus erthematosus

Country Status (1)

Country Link
WO (1) WO2009111476A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955359A (en) * 1995-08-25 1999-09-21 University Of Maryland At Baltimore Method of growing granulocytic ehrlichiae of the Ehrlichia phagocytophila genogroup in promyelocytic leukemia cell culture, and preparing antigens and vaccines of said granulocytic ehrlichiae
US20060051778A1 (en) * 2004-03-31 2006-03-09 Kallick Charles A Diagnosis of systemic lupus erythematosus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955359A (en) * 1995-08-25 1999-09-21 University Of Maryland At Baltimore Method of growing granulocytic ehrlichiae of the Ehrlichia phagocytophila genogroup in promyelocytic leukemia cell culture, and preparing antigens and vaccines of said granulocytic ehrlichiae
US20060051778A1 (en) * 2004-03-31 2006-03-09 Kallick Charles A Diagnosis of systemic lupus erythematosus

Also Published As

Publication number Publication date
WO2009111476A2 (en) 2009-09-11

Similar Documents

Publication Publication Date Title
WO2013113699A3 (en) Hyperthermophilic polymerase enabled proximity extension assay
WO2006050499A3 (en) Single step detection assay
WO2008086335A3 (en) Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
WO2008003116A3 (en) Method for engineering immunoglobulins
WO2011022077A3 (en) A nucleic acid cassette for producing recombinant antibodies
NZ610267A (en) A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
AR077594A1 (en) COMPLETELY HUMAN ANTIBODIES FOR BTLA (ATTENUANT OF B AND T LYMPHOCYTES)
WO2012019187A3 (en) Ligation-based detection of genetic variants
WO2011087916A3 (en) Force mediated assays
WO2008035205A3 (en) Recombinase polymerase amplification
WO2009052400A8 (en) Antibodies that bind to mammalian ngal and uses thereof
WO2008070082A3 (en) Stem-progenitor cell specific micro-ribonucleic acids and uses thereof
WO2004081174A3 (en) Marker for detecting mesenchymal stem cell and method of distinguishing mesenchymal stem cell using the marker
BRPI0812878C1 (en) isolated antibody or functional part thereof, vector, method for producing an antibody or a functional part thereof, for producing an antibody-producing cell and for producing an antibody capable of specifically binding to rsv, composition, and use of an antibody or functional part of it or of a composition or vector
AU2009209251A8 (en) Stabilized Angiopoietin-2 antibodies and uses thereof
WO2010118411A3 (en) Improved methods for conducting assays
WO2008122793A3 (en) Blood group antibody screening
WO2012038820A3 (en) Immunochromatography devices, methods and kits
NZ598770A (en) Monoclonal antibodies
WO2008005880A3 (en) Antibodies for norovirus
WO2010009203A3 (en) Lateral flow nucleic acid detector
WO2008008858A3 (en) Cellspot™ applications
WO2007087521A3 (en) Cd86 and cd80 receptor competition assays
WO2011142781A3 (en) Pore-limit electrophoresis (ple) microchannel assays
WO2011161420A3 (en) Coincidence detection

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09716538

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09716538

Country of ref document: EP

Kind code of ref document: A2