WO2009100591A1 - Use of hydrochloric acid for the manufacture of medicine in treating vascular disease - Google Patents

Use of hydrochloric acid for the manufacture of medicine in treating vascular disease Download PDF

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Publication number
WO2009100591A1
WO2009100591A1 PCT/CN2008/000409 CN2008000409W WO2009100591A1 WO 2009100591 A1 WO2009100591 A1 WO 2009100591A1 CN 2008000409 W CN2008000409 W CN 2008000409W WO 2009100591 A1 WO2009100591 A1 WO 2009100591A1
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hydrochloric acid
medicament
acid according
preparation
blood vessels
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PCT/CN2008/000409
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French (fr)
Chinese (zh)
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Deshou Wang
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Deshou Wang
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Definitions

  • the present invention relates to the use of hydrochloric acid for the preparation of a medicament for the treatment of vascular diseases, in particular an aqueous solution containing hydrochloric acid, which can be used for injection or drinking.
  • the long-organized, unscientific diet of the human body has formed capillary occlusion and arterial vascular hardening.
  • the blockage and hardening become more and more serious, destroying the normal function of the human organs, leading to a large number of vascular diseases.
  • stomach acid is hydrochloric acid
  • plaque on the wall of blood vessels called thrombosis, atheroma in the medical community
  • internal stones in organs should not and never contain calcium carbonate, calcium oxalate, calcium phosphate, etc. Alkaline substance.
  • hydrochloric acid in the stomach described in the physiology textbook is the synthesis of hydrochloric acid by the ammonia ion in the stomach and the chloride ion in the plasma. There is absolutely no chlorine ion in the plasma, and people with chloride ions will die of poisoning. The chlorine in sodium chloride is never released separately and combines with hydrogen ions to form hydrochloric acid.
  • the human body is "three high," and the blood is acidified. Its root is scaling at the entrance of capillaries and cells (calcified by the medical community), so that the nutrients in the blood cannot be absorbed and consumed by the cells.
  • the binder binds the metabolites in the blood vessels (all acidic substances do not bind; the blocked blood vessels that must be bonded must be alkaline substances).
  • the medical community treats the phenomenon of blood acidification as a disease. Calling people to eat the essentially bonded theophylline, spirulina, and propolis to control the acidification of blood in diabetes. When starting to take it, neutralizing the acid in the blood temporarily relieves the condition, but at the same time accelerates the blockage of blood vessels and capillaries. Accelerate death.
  • Decomposition of calcium carbonate in water and food can form a bond, bonding metabolites (such as cholesterol) and solid matter to arteries and capillaries, scaling with arteries and capillaries with age. Thicker and thicker, the pore size of the blood vessels becomes thinner and finer, so that the blood flow is smoother and the blood/ ⁇ is raised.
  • the scale on the blood vessel wall weakens the elasticity of the blood vessels and limits the automatic adjustment of blood pressure.
  • the scale on the wall of the blood vessel destroys the blood vessel and is reduced in its own elasticity.
  • the drugs and therapeutic instruments for treating hypertension in human vascular diseases are all dilating arterial blood vessels, repeatedly expanding blood vessels to accelerate the aging of arterial blood vessels, and while repeatedly expanding, deposits of blood vessel walls may fall off and block blood vessels, causing myocardial infarction. And other diseases.
  • the object of the present invention is to propose the use of a certain concentration of hydrochloric acid water in the treatment of vascular diseases, Taking the hydrochloric acid water medicine, the calcium carbonate oxalate can be dissolved, and other bonded particulate matter can be separated and discharged to remove the scale on the blood vessel, so that the blood vessel returns to normal.
  • hydrochloric acid is the most ideal substance for dissolving calcium carbonate and calcium oxalate in the body, and that hydrochloric acid is adsorbed on the inner wall by the vascular protective membrane, which can repair damaged blood vessels and restore blood pressure to normal.
  • the technical solution of the present invention is the application of hydrochloric acid in the preparation of a medicament for treating vascular diseases.
  • the drug is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is controlled at 4-7.
  • the pH of the aqueous solution is controlled at 6.5-7. More precisely, the PH value is controlled at 3. 5 - 5. 5, and the best PH value is 3. 5.
  • the drug is an oral liquid dosage form or an injection dosage form.
  • the medicament may also be added to a physiological saline or glucose solution beverage, or may be composed of medical salicylic acid + mineral water containing a large amount of trace elements + various vitamins + amino acids + nutrients.
  • the production of the drug includes the following processes:
  • One-to-one mixing generator (adding vitamins) - one mixing generator (adding amino acids) - one mixing generator (adding nutrients - one vessel generator (adding hydrochloric acid)
  • One-to-one aseptic mixer - one buffer tank - one ultrafiltration system - one ozone sterilization - one ultraviolet disinfection one import filling machine canned one one mouth one by one label one by one packaging one ultraviolet disinfection one by one .
  • the method for administering a hydrochloric acid preparation medicine of the present invention when treating hypertension, is applied not less than 1500 ml per day, and is divided into 3-6 drinking times, and 3-6 months is a course of treatment.
  • the injection dosage form of the medicine for injection is used for the treatment of hypertension, and the recommended amount per sputum is 500 ml, which is divided into two injections, intravenous infusion, and is continuously treated for 2-3 months.
  • the invention prepares the medicine prepared by the hydrochloric acid of the high purity hydrochloric acid invention to treat hypertension It is fully reliable, has a definite and obvious effect, and has obvious improvement effects on hypertensive patients with arteriosclerosis, and can convert calcium salts harmful to the human body into calcium required by the human body.
  • the medicament is usually an aqueous solution containing hydrochloric acid.
  • the pH value is controlled at 4-7, and the solution having a pH of 6. 5-7 can be directly cited as a beverage, and oral liquid and injection solution and other dosage forms can be prepared.
  • the daily application of edible oral liquid for the treatment of hypertension is preferably no less than 1500ml, divided into 3-6 times, and 3-6 months is a course of treatment.
  • the recommended daily dose is 500ml, divided into two injections.
  • Intravenous infusion, for 2 to 3 months for a course of treatment according to the above usage and dosage of high blood pressure, the general dose can be reduced by 1 / 4 after one year, halved after two years, .. generally only maintained after three years The amount or free of antihypertensive drugs, blood pressure returned to normal.
  • the oral liquid can be prepared manually as follows: Hydrochloric acid is added to the drinking water and stirred evenly. The accurate detection before filling and sterilization is controlled at 4-7; the pH value of edible hydrochloric acid water is controlled at 6.5-7.
  • the pH control device can be used to continuously, stably and in large quantities prepare the above aqueous solution containing hydrochloric acid.
  • the injection can be prepared by a pharmaceutically acceptable method using hydrochloric acid as long as the pH of the injection is controlled to be 4 - 7.
  • the hydrochloric acid of the present invention can also be used in other solutions, such as physiological saline, dextrose solution beverage, etc., and the preparation method is the same as above, and only the pH value of the oral liquid or the injection can be controlled.
  • the edible hydrochloric acid water of the present invention generally does not allow heating reference, because heating causes the hydrochloric acid to volatilize and loses its therapeutic effect, and does not drink beverages and tea which are easily scaled, and the neutralization of theophylline and hydrochloric acid loses its effect.
  • PH 3. 5-35. 5
  • a certain concentration of hydrochloric acid water after entering the human body, through the metabolic system to enter the human blood vessels, can effectively soften the blood vessels and eliminate, dissolve vascular blockage and hardening, and restore the normal function of human organs, Effective treatment of various vascular diseases.
  • the high-purity hydrochloric acid is added to a hydrochloric acid solution diluted to 2% in drinking water, and filled in a hydrochloric acid solution tank with a flow controller, and the hydrochloric acid solution and the drinking water are mixed at a certain flow ratio through a pipeline, and the end of the pipeline is set.
  • the pH detector is controlled to control the pH of the aqueous hydrochloric acid solution at 3.5 - 5. 5 to obtain medicinal hydrochloric acid water.
  • 11 140/90 76 After taking the drug for 3 years, I stopped taking the drug for 1 year. I have not taken the blood pressure lowering drug for 1 year. The blood pressure is stable at 120/80. 12 150/100 58 After taking 2 years, after 1 year, the dose is reduced by 1/4, the dose is reduced by half in 2 years, the medication is stopped after 3 years, and the blood pressure is stable at 130/85.
  • the dose is halved, the drug is taken after 3 and a half years, and the blood pressure is stable at 130/80.
  • the practical drug for vascular disease is safe and reliable. It has exact and obvious. The effect is also obvious to the hypertensive patients with arteriosclerosis, and can convert the calcium salts that harm the human body into the calcium needed by the human body. Therefore, the present invention has industrial applicability.

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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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Abstract

An application of hydrochloric acid in the manufacture of medicine for treating vascular disease. The medicine comprising HCl, is in the form of aqueous composition, with pH 4-7, or an oral liquid composition with pH 6.5-7.

Description

一定浓度的盐酸水在治疗血管疾病中的应用 技术领域  Application of a certain concentration of hydrochloric acid in the treatment of vascular diseases
本发明涉及盐酸在制备治疗血管疾病药物中的应用, 所述的药物特别 为含有盐酸的水溶液, 可用于注射或饮用。  The present invention relates to the use of hydrochloric acid for the preparation of a medicament for the treatment of vascular diseases, in particular an aqueous solution containing hydrochloric acid, which can be used for injection or drinking.
背景技术 Background technique
人体血管疾病的形成, 到目前为止, 还没有根治的方法。 也就是说, 人一旦得了血管疾病(心肌梗塞、 高血压、糖尿病、前列腺炎、脉管炎等), 就很难能彻底治愈了, 必须靠药物终生维护。  The formation of human vascular disease, so far, there is no cure. In other words, once a person has vascular disease (myocardial infarction, hypertension, diabetes, prostatitis, vasculitis, etc.), it is difficult to completely cure, and must rely on the drug for life maintenance.
人体长期以来无序、 不科学的饮食形成了毛细血管堵塞和动脉血管硬 化现象。 随着年龄的增大, 堵塞和硬化现象越来越严重, 破坏人体器官正 常功能, 导致血管疾病地大量出现。  The long-organized, unscientific diet of the human body has formed capillary occlusion and arterial vascular hardening. As the age increases, the blockage and hardening become more and more serious, destroying the normal function of the human organs, leading to a large number of vascular diseases.
人体血管疾病的形成, 医学界存在诸多学说, 遗传因素, 内分泌失调, 饮食不良等,但无论是哪一种学说都难以找到一种能治愈血管疾病的方法。  The formation of human vascular diseases, the medical community has many doctrines, genetic factors, endocrine disorders, poor diet, etc., but no matter which theory is difficult to find a way to cure vascular diseases.
发明人在研究人类消化系统、 高血压和糖尿病的过程中, 发现了 1 8 33 年美国生理学之父鲍芒确定的胃酸即盐酸的理论是错误的, 由于该理论的 错误阻碍了医学界对高血压、 糖尿病的解剖。 接着发现了医学界根据细胞 里有血糖, 而且有些糖尿病的人血液中的血糖高, 胰岛素也高的现象, 认 为胰岛素是降解血糖的, 事实证明它也是错误的。 发明人最大的发现是碳 酸氢钙不稳定, 容易分解生成的碳酸钙有二大性质; 一是薄色沉淀物, 二 是在一定的温度和环境条件下是粘结剂。 根据钟乳石的形成就足以证明该 性质的存在。 至今为止, 所有教科书上都没有这个性质。 由于本人发现了 碳酸氢钙分解后生成的碳酸钙具有粘结剂的功能, 才导致发现了人类高血 压、 糖尿病等一系列疾病的形成机理和根治方法。  In the process of studying human digestive system, hypertension and diabetes, the inventors discovered that the theory of gastric acid, namely hydrochloric acid, determined by Bowman, the father of American physiology in 1983, was wrong, because the mistake of the theory hindered the medical profession. Anatomy of blood pressure and diabetes. Then, it was discovered that the medical community has blood sugar in the cells, and some people with diabetes have high blood sugar and high insulin in the blood. It is considered that insulin is degrading blood sugar, which proves to be wrong. The inventor's biggest finding is that calcium hydrogencarbonate is unstable, and calcium carbonate which is easily decomposed has two major properties; one is a thin color precipitate, and the other is a binder under certain temperature and environmental conditions. According to the formation of stalactites, it is enough to prove the existence of this property. So far, there is no such property in all textbooks. Since I discovered that the calcium carbonate formed by the decomposition of calcium bicarbonate has the function of a binder, it has led to the discovery of a formation mechanism and a cure method for a series of diseases such as human hypertension and diabetes.
所有医学教科书上都认为胃酸即盐酸, 那么它为什么是错误的呢? All medical textbooks think that stomach acid is hydrochloric acid, so why is it wrong?
1. 如果胃酸即盐酸, 那么血管壁上的斑块(医学界称血栓、 粥样斑块) 和器官内在的结石中不应该而且永远不会含有碳酸钙、 草酸钙、 磷酸钙等 碱性物质。 1. If stomach acid is hydrochloric acid, plaque on the wall of blood vessels (called thrombosis, atheroma in the medical community) and internal stones in organs should not and never contain calcium carbonate, calcium oxalate, calcium phosphate, etc. Alkaline substance.
2 . 使用含有盐酸的溶液 (其含量只要达到和接近教科书中所谓胃酸 的量), 所有胃病都会痊愈, 既然胃内有盐酸, 那么人类就不应该得胃病。  2. Using a solution containing hydrochloric acid (as long as it reaches and approaches the amount of so-called gastric acid in the textbook), all stomach problems will heal. Since there is hydrochloric acid in the stomach, humans should not get stomach problems.
3 . 生理学教科书中阐述的胃内盐酸的生成, 是胃内的氨离子和血浆 中氯离子合成生成盐酸。 血浆中绝对没有氯离子, 有氯离子人就会中毒死 亡。 氯化钠中的氯绝对不会单独游离出来和氢离子结合生成盐酸。  3. The formation of hydrochloric acid in the stomach described in the physiology textbook is the synthesis of hydrochloric acid by the ammonia ion in the stomach and the chloride ion in the plasma. There is absolutely no chlorine ion in the plasma, and people with chloride ions will die of poisoning. The chlorine in sodium chloride is never released separately and combines with hydrogen ions to form hydrochloric acid.
4 . 1883年是绝对没有这样的设备能检测每立方米胃液中含有 (胃液 中含有有机酸、 氢离子、 碳酸) 20-25 摩尔的盐酸, 就是现在也没有这样 的设备。  4. In 1883, there was absolutely no such equipment capable of detecting 20-25 moles of hydrochloric acid per stomach cubic meter of gastric juice (organic acid, hydrogen ion, carbonic acid in gastric juice), and there is no such equipment.
人体 "三高,, , 血液酸性化, 它的病根是在毛细血管、 细胞入口处结 垢 (医学界称钙化) , 使血液中的营养无法供细胞吸收、 消耗所至。 血管 阻塞是碱性粘结剂把代谢物粘结在血管内 (所有酸性物质是不会粘结的;: 要粘结起来的阻塞血管的一定是碱性物质) 。 医学界把血液酸性化的现象 当病治, 号召人们食用极其会粘结的茶碱、 螺旋藻、 蜂胶来控制糖尿病 血液酸性化。 开始服用时, 中和血液中的酸, 暂时緩解了病情, 但同时加 速血管及毛细血管的阻塞, 使人加速死亡。  The human body is "three high," and the blood is acidified. Its root is scaling at the entrance of capillaries and cells (calcified by the medical community), so that the nutrients in the blood cannot be absorbed and consumed by the cells. The binder binds the metabolites in the blood vessels (all acidic substances do not bind; the blocked blood vessels that must be bonded must be alkaline substances). The medical community treats the phenomenon of blood acidification as a disease. Calling people to eat the essentially bonded theophylline, spirulina, and propolis to control the acidification of blood in diabetes. When starting to take it, neutralizing the acid in the blood temporarily relieves the condition, but at the same time accelerates the blockage of blood vessels and capillaries. Accelerate death.
例如, 人体血管疾病中的高血压病的形成有以下原因:  For example, the formation of hypertension in human vascular disease has the following reasons:
1 .水中和食物中的碳酸钙分解可生成粘接物,将代谢物(如胆固醇等) 和固态物粘接在动脉血管和毛细血管上, 随年龄增大, 动脉血管和毛细血 管的结垢越来越厚, 血管孔径越来越细, 从而使血流补畅, 血/ ί升高。  1. Decomposition of calcium carbonate in water and food can form a bond, bonding metabolites (such as cholesterol) and solid matter to arteries and capillaries, scaling with arteries and capillaries with age. Thicker and thicker, the pore size of the blood vessels becomes thinner and finer, so that the blood flow is smoother and the blood/ί is raised.
2 .血管壁上的积垢使血管弹性减弱, 限制血压的自动调节。  2. The scale on the blood vessel wall weakens the elasticity of the blood vessels and limits the automatic adjustment of blood pressure.
3. 血管壁上的积垢破坏了血管, 是其本身的弹性降低。  3. The scale on the wall of the blood vessel destroys the blood vessel and is reduced in its own elasticity.
目前, 治疗人体血管疾病中的高血压的药物和治疗仪器都是扩张动脉 血管, 反复扩张血管加速动脉血管的老化, 并且在反复扩张的同时, 血管 壁的沉积物会脱落阻塞血管, 造成心肌梗塞等疾病。  At present, the drugs and therapeutic instruments for treating hypertension in human vascular diseases are all dilating arterial blood vessels, repeatedly expanding blood vessels to accelerate the aging of arterial blood vessels, and while repeatedly expanding, deposits of blood vessel walls may fall off and block blood vessels, causing myocardial infarction. And other diseases.
发明内容 Summary of the invention
本发明的目的是提出使用一定浓度的盐酸水在治疗血管疾病中的应用, 服用该盐酸水药物, 可以把粘结物碳酸钙河草酸钙溶解, 使其他粘结的颗 粒物质分离排出体外, 以去掉血管上的积垢, 使血管恢复正常。 The object of the present invention is to propose the use of a certain concentration of hydrochloric acid water in the treatment of vascular diseases, Taking the hydrochloric acid water medicine, the calcium carbonate oxalate can be dissolved, and other bonded particulate matter can be separated and discharged to remove the scale on the blood vessel, so that the blood vessel returns to normal.
发明人发现, 盐酸是最理想的溶解体内碳酸钙和草酸钙的物质, 同时 盐酸被血管保护膜吸附在内壁上, 能够修复损伤的血管, 使血压恢复正常。  The inventors have found that hydrochloric acid is the most ideal substance for dissolving calcium carbonate and calcium oxalate in the body, and that hydrochloric acid is adsorbed on the inner wall by the vascular protective membrane, which can repair damaged blood vessels and restore blood pressure to normal.
本发明的技术方案是盐酸在制备治疗血管疾病药物中的应用。  The technical solution of the present invention is the application of hydrochloric acid in the preparation of a medicament for treating vascular diseases.
所述的药物为含有盐酸的水溶液, 所述水溶液的 PH值控制在 4- 7。 作 为口服液, 所述水溶液的 PH值控制在 6. 5-7。 更精确为 PH值控制在 3. 5 - 5. 5, 最佳为 PH值是 3. 5。  The drug is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is controlled at 4-7. As an oral solution, the pH of the aqueous solution is controlled at 6.5-7. More precisely, the PH value is controlled at 3. 5 - 5. 5, and the best PH value is 3. 5.
所述的药物为口服液剂型或注射剂剂型。  The drug is an oral liquid dosage form or an injection dosage form.
所述的药物还可以加入生理盐水或葡萄糖溶液饮料中, 或采用医用盐 酸 +含有大量微量元素的矿泉水 +各种维生素 +氨基酸 +营养素组成。  The medicament may also be added to a physiological saline or glucose solution beverage, or may be composed of medical salicylic acid + mineral water containing a large amount of trace elements + various vitamins + amino acids + nutrients.
所述的药物的生产包括如下工艺:  The production of the drug includes the following processes:
原水一机械过滤器一活性碳过滤器—— 5 u m精密过滤—— 1 u m精密过 滤一一中控纤维超滤系统一一反渗透装置一一緩沖器一一混合发生器 (添 加铁、 锌、 锰、 电、 钴、 锶、 铬、 硒等微量元素) 一一混合发生器 (添加 维生素) 一一混合发生器 (添加氨基酸) 一一混合发生器 (添加营养素 一一器皿发生器 (添加盐酸) 一一无菌混合器一一緩沖罐一一超滤系统一 一臭氧杀菌一一紫外线杀菌一一进口灌装机罐装一一封口一一贴商标一一 包装一一紫外线杀菌照射一一入库。  Raw water-mechanical filter-activated carbon filter - 5 um precision filtration - 1 um precision filtration - one central control fiber ultrafiltration system - one reverse osmosis device - one buffer one by one mixing generator (add iron, zinc, Manganese, electricity, cobalt, antimony, chromium, selenium and other trace elements) One-to-one mixing generator (adding vitamins) - one mixing generator (adding amino acids) - one mixing generator (adding nutrients - one vessel generator (adding hydrochloric acid) One-to-one aseptic mixer - one buffer tank - one ultrafiltration system - one ozone sterilization - one ultraviolet disinfection one import filling machine canned one one mouth one by one label one by one packaging one ultraviolet disinfection one by one .
本发明的盐酸制备药物的服用方法, 在治疗高血压时, 每日应用不少 于 1500m l, 分为 3-6次饮用, 3— 6个月为一个疗程。  The method for administering a hydrochloric acid preparation medicine of the present invention, when treating hypertension, is applied not less than 1500 ml per day, and is divided into 3-6 drinking times, and 3-6 months is a course of treatment.
最好每日饮用 2000m l, 分三次饮用, 早中餐前一小时各饮 500m l ,晚餐 前饮 1000m l , —年后一般服药量可减少 1 /4 , 二年后减半, 三年后一般只 服维持量或免服降压药。 所述口服液剂不容许加热饮用。  It is best to drink 2000ml per day, drink it in three portions. Drink 500m l one hour before breakfast and lunch, and 1000m l before dinner. After the year, the general dose can be reduced by 1/4, and after two years, it will be halved. After three years, generally Only take maintenance dose or exempt from antihypertensive drugs. The oral liquid is not allowed to be heated for drinking.
所述的注射剂剂型药物在注射用治疗高血压时, 每曰的推荐量为 500m l , 分两次注射, 静脉滴注, 连续 2— 3个月为一个疗程。  The injection dosage form of the medicine for injection is used for the treatment of hypertension, and the recommended amount per sputum is 500 ml, which is divided into two injections, intravenous infusion, and is continuously treated for 2-3 months.
本发明将高纯度的盐酸发明所述的盐酸制备制得的药物治疗高血压安 全可靠, 有着确切、 明显的效杲, 对动脉血管硬化的高血压患者也有明显 的改善作用, 并可以使危害人体的钙盐转化为人体需要的钙。 The invention prepares the medicine prepared by the hydrochloric acid of the high purity hydrochloric acid invention to treat hypertension It is fully reliable, has a definite and obvious effect, and has obvious improvement effects on hypertensive patients with arteriosclerosis, and can convert calcium salts harmful to the human body into calcium required by the human body.
为说明本发明的治疗效果,对 132例使用食用盐酸水的血管病 患者进 行临床观察。 其中男 97例, 女 35例, 平均年龄 67. 5岁, 年龄范围 52— 84岁。 使用结果表明, 食用盐酸水或配合其他药物, 如降压药, 患者治愈 89例, 血压控制在正常范围的 30例, 服降压药达不到正常范围和高血压 患者, 食用盐酸水一年半后, 在服用同样的降压药, 血压能控制在正常范 围的 1 3例。  To illustrate the therapeutic effect of the present invention, 132 patients with vascular disease using edible hydrochloric acid water were clinically observed. There were 97 males and 35 females with an average age of 67. 5 years old and an age range of 52-84 years old. The results showed that the consumption of hydrochloric acid water or other drugs, such as antihypertensive drugs, patients cured 89 cases, blood pressure control in the normal range of 30 cases, taking antihypertensive drugs can not reach the normal range and high blood pressure patients, drinking hydrochloric acid for one year After half, taking the same antihypertensive drug, blood pressure can be controlled in the normal range of 13 cases.
具体实施方式 detailed description
本发明在制备药物时, 通常药物是含有盐酸的水溶液 PH值控制在 4一 7, PH值在 6. 5— 7的溶液可作为饮料直接引用, 可以制备口服液和注射液 以及其他剂型。 食用口服液治疗高血压时每日应用最好不少于 1500ml , 分 为 3- 6次饮用, 3— 6个月为一个疗程。 在注射用治疗高血压时, 每日的推 荐量为 500ml , 分两次注射。 静脉滴注, 连续 2— 3个月为一个疗程, 按上 述用法及用量治疗高血压, 一年后一般服药量可减少 1 /4 , 二年后减半,.. 三年后一般只服维持量或免服降压药, 血压恢复正常。  In the preparation of the medicament, the medicament is usually an aqueous solution containing hydrochloric acid. The pH value is controlled at 4-7, and the solution having a pH of 6. 5-7 can be directly cited as a beverage, and oral liquid and injection solution and other dosage forms can be prepared. The daily application of edible oral liquid for the treatment of hypertension is preferably no less than 1500ml, divided into 3-6 times, and 3-6 months is a course of treatment. In the treatment of hypertension for injection, the recommended daily dose is 500ml, divided into two injections. Intravenous infusion, for 2 to 3 months for a course of treatment, according to the above usage and dosage of high blood pressure, the general dose can be reduced by 1 / 4 after one year, halved after two years, .. generally only maintained after three years The amount or free of antihypertensive drugs, blood pressure returned to normal.
可以按如下方法人工制备口服液: 盐酸加入饮用水中搅拌均匀, 灌装 灭菌前精确检测 PH值控制在 4一 7; 食用盐酸水的 PH值控制在 6. 5— 7。  The oral liquid can be prepared manually as follows: Hydrochloric acid is added to the drinking water and stirred evenly. The accurate detection before filling and sterilization is controlled at 4-7; the pH value of edible hydrochloric acid water is controlled at 6.5-7.
工业配制时, 可采用 PH值控制装置来进行连续、 稳定、 大批量地制备 上述含有盐酸的水溶液。  In the industrial preparation, the pH control device can be used to continuously, stably and in large quantities prepare the above aqueous solution containing hydrochloric acid.
可以用盐酸按药学上通常的方法制备注射剂,只要控制注射剂 PH值在 4 - 7即可。  The injection can be prepared by a pharmaceutically acceptable method using hydrochloric acid as long as the pH of the injection is controlled to be 4 - 7.
采用自来水制备盐酸水时, 一般应在前端设置净化装置使其达到国家 饮用水的卫生标准。  When using tap water to prepare hydrochloric acid water, it is generally necessary to provide a purification device at the front end to meet the national sanitary standard for drinking water.
为了治疗血管病的目的, 本发明所述的盐酸也可以用于其他溶液中, 如生理盐水, 葡萄糖溶液饮料等, 其配制方法同上, 只须控制口服液或注 剂的 PH值即可。 本发明食用盐酸水一般不容许加热引用, 因为加热使盐酸挥发而失去 疗效, 也不要饮用容易结垢的饮料和茶水, 茶碱和盐酸中和失去作用。 For the purpose of treating vascular diseases, the hydrochloric acid of the present invention can also be used in other solutions, such as physiological saline, dextrose solution beverage, etc., and the preparation method is the same as above, and only the pH value of the oral liquid or the injection can be controlled. The edible hydrochloric acid water of the present invention generally does not allow heating reference, because heating causes the hydrochloric acid to volatilize and loses its therapeutic effect, and does not drink beverages and tea which are easily scaled, and the neutralization of theophylline and hydrochloric acid loses its effect.
通过临床观察浓度在 PH=3. 5时治疗效果最好,但是由于人体的个性化 差异, 推广浓度在 PH=3. 5- 5. 5都是比较有效的、 安全的。  The clinical observation concentration is best at PH=3.5, but due to the individualized differences of the human body, the promotion concentration is relatively effective and safe at PH=3.5- 5.5.
PH=3. 5-35. 5的一定浓度的盐酸水, 在进入人体后, 通过代谢体统进 取人体血管中, 能有效地软化血管和消除、 溶解血管堵塞和硬化现象, 恢 复人体器官正常功能, 有效治疗各种血管疾病。  PH=3. 5-35. 5 A certain concentration of hydrochloric acid water, after entering the human body, through the metabolic system to enter the human blood vessels, can effectively soften the blood vessels and eliminate, dissolve vascular blockage and hardening, and restore the normal function of human organs, Effective treatment of various vascular diseases.
为了是治疗效果更好。 提供一种本发明的产品成分配方:  In order to be better therapeutic. A product ingredient formulation of the invention is provided:
医用盐酸 +矿泉水 (含有大量微量元素) +维生素 (AECBD ) +氨基酸 + 其它营养素等组成。  Medical hydrochloric acid + mineral water (containing a large amount of trace elements) + vitamins (AECBD) + amino acids + other nutrients.
实施例 1  Example 1
将高纯度的盐酸加入饮用水中搅拌, 精确控制值 6. 5-7, 可以直接服 用。  Add high-purity hydrochloric acid to the drinking water and stir it. The precise control value is 6. 5-7, which can be used directly.
实施例 1  Example 1
将高纯度的盐酸加入饮用水稀释至 2 %的盐酸溶液, 灌装于带有流量 控制器的盐酸溶液罐中, 将上述盐酸溶液和饮用水以一定流量比经管道混 合,所述管道末端设置 PH值检测器;控制盐酸水溶液的 PH值在 3. 5 - 5. 5 , 制得药用盐酸水。  The high-purity hydrochloric acid is added to a hydrochloric acid solution diluted to 2% in drinking water, and filled in a hydrochloric acid solution tank with a flow controller, and the hydrochloric acid solution and the drinking water are mixed at a certain flow ratio through a pipeline, and the end of the pipeline is set. The pH detector is controlled to control the pH of the aqueous hydrochloric acid solution at 3.5 - 5. 5 to obtain medicinal hydrochloric acid water.
本产品完全按照国际 ISO-9001质量认证标准执行。采用科学的配伍方 法, 把人体所必需的营养元素按照一定比例、 一定量地配合起来, 经过 24 道工艺流程生产而成, 其生产工艺如下:  This product is fully implemented in accordance with international ISO-9001 quality certification standards. Using the scientific compatibility method, the essential nutrients of the human body are matched according to a certain proportion and quantitatively, and are produced through 24 processes. The production process is as follows:
原水一机械过滤器一活性碳过滤器一一 5um精密过滤一一 lum精密过 滤一一中控纤维超滤系统一一反渗透装置一一緩冲器一一混合发生器 (添 加铁、 锌、 锰、 电、 钴、 锶、 铬、 硒等微量元素) 一一混合发生器 (添加 维生素) 一一混合发生器 (添加氨基酸) 一一混合发生器 (添加营养素) 一一器皿发生器 (添加盐酸) 一一无菌混合器一一緩沖罐一一超滤系统一 一臭氧杀菌一一紫外线杀菌一一进口灌装机罐装一一封口一一贴商标一一 包装一一紫外线杀菌照射一一入库 Raw water, mechanical filter, activated carbon filter, one by one, 5um precision filtration, one lum precision filtration, one central control fiber ultrafiltration system, one reverse osmosis device, one buffer, one hybrid generator (adding iron, zinc, manganese , electric, cobalt, antimony, chromium, selenium and other trace elements) one-mix generator (add vitamins) one-mix generator (add amino acid) one-mix generator (add nutrients) one-of-a-kind generator (add hydrochloric acid) One-to-one aseptic mixer, one buffer tank, one ultrafiltration system, one ozone sterilization, one ultraviolet sterilization, one imported filling machine, one can be one, one mouth, one trademark, one trademark Packaging one by one ultraviolet sterilization irradiation into the library
采用上述制得的盐酸水对 17例高血压患者进行治疗观察, 患者每曰饮 用 2000ml, 分三次饮用, 早中餐前一小时各饮 500ml,晚餐前饮 1000ml。 其疗效如表 1所述: 患者编号 原血压 年龄 疾病治疗情况  Seventeen patients with hypertension were treated with the hydrochloric acid water prepared above. The patient used 2000 ml per sip, divided into three drinks, 500 ml each one hour before the morning meal, and 1000 ml before dinner. The efficacy is as described in Table 1: Patient number, original blood pressure, age, disease treatment
1 130/110 65 服用 2年后,药量减半, 3年后停止服药,血 压稳定在 110/80  1 130/110 65 After taking 2 years, the dose was halved, and after 3 years, the medication was stopped and the blood pressure was stable at 110/80.
2 180/110 62 服用 3年后,药量减半,血压稳定在 130/90 2 180/110 62 After taking 3 years, the dose is halved and the blood pressure is stable at 130/90
3 180/105 72 服用 2年, 1年后药量减少 1/4,现已一年 不服降血压,血压稳定在 140/95 3 180/105 72 After taking 2 years, after 1 year, the dose is reduced by 1/4. Now it is not taking blood pressure for one year, and the blood pressure is stable at 140/95.
4 150/90 74 服用 2年后,药量减半, 4年后停止服药, 现已一年不服降血压,血压稳定在 110/75 4 150/90 74 After taking 2 years, the dose is halved, and after 4 years, the medicine is stopped. It has not been taken for one year to lower blood pressure, and the blood pressure is stable at 110/75.
5 200/100 83 服用 2年后,药量减半, 2年半后断服药, 现已一年不服降血压,血压稳定在 140/855 200/100 83 After taking 2 years, the dose is halved. After 2 and a half years, the medicine is broken. It has not been taken for one year to lower blood pressure, and the blood pressure is stable at 140/85.
6 180/90 86 服用 2年, 1年后药量减少 1/4, 3年后 停止服药,血压稳定在 130/80 6 180/90 86 After taking 2 years, the dose is reduced by 1/4 after 1 year. After 3 years, the medicine is stopped and the blood pressure is stable at 130/80.
7 160/100 63 服用 1年后,药量减半, 2年后停止服药,血 压稳定在 120/70  7 160/100 63 After taking 1 year, the dose is halved. After 2 years, the medicine is stopped and the blood pressure is stable at 120/70.
8 150/90 82 服用 2年后,药量减半, 3年后停止服药, 现已一年不服降血压,血压稳定在 110/70 8 150/90 82 After taking 2 years, the dose is halved, and after 3 years, the medicine is stopped. It has not been taken for one year to lower blood pressure, and the blood pressure is stable at 110/70.
9 170/110 75 服用 1年半后,药量减半, 4年后断药,血压 稳定在 130/80 9 170/110 75 After 1 and a half years, the dose was halved, and after 4 years, the drug was broken and the blood pressure was stable at 130/80.
10 160/95 56 2000年开始服用, 2年后药量减半,血压稳 定在 125/80  10 160/95 56 started taking in 2000, after half a year, the dose was halved and the blood pressure was stable at 125/80
11 140/90 76 服用 3年后停止服药, 现已 1年不服降血 压药,血压稳定在 120/80 12 150/100 58 服用 2年, 1年后药量减少 1/4, 2年药 量减半, 3年后停止服药,血压稳定在 130/8511 140/90 76 After taking the drug for 3 years, I stopped taking the drug for 1 year. I have not taken the blood pressure lowering drug for 1 year. The blood pressure is stable at 120/80. 12 150/100 58 After taking 2 years, after 1 year, the dose is reduced by 1/4, the dose is reduced by half in 2 years, the medication is stopped after 3 years, and the blood pressure is stable at 130/85.
13 190/110 73 服用 2年半后,药量减半, 3年后断药,血压 稳定在 140/90 13 190/110 73 After taking 2 and a half years, the dose is halved, and after 3 years, the drug is broken and the blood pressure is stable at 140/90.
14 160/95 81 服用 1年半后,药量减半, 4年后停止服药, 现已一年不服降血压,血压稳定在 130/85 14 160/95 81 After taking one and a half years, the dose is halved, and after 4 years, the medicine is stopped. It has not been taken for one year to lower blood pressure, and the blood pressure is stable at 130/85.
15 170/100 59 服用 2年后,药量减半,血压稳定在 135/7515 170/100 59 After taking 2 years, the dose is halved and the blood pressure is stable at 135/75
16 180/90 67 服用 2年后,药量减半,血压稳定在 140/8516 180/90 67 After taking 2 years, the dose is halved and the blood pressure is stable at 140/85
17 160/90 76 服用 1年后,药量减半, 3年半后断服药,血 压稳定在 130/80 工业实用性 血管疾病的药物, 所述药物治疗高血压安全可靠, 有着确切、 明显的效果, 对动脉血管硬化的高血压患者也有明显的改善作用, 并可以使危害人体的 钙盐转化为人体需要的钙。 因此, 本发明具有工业实用性。 17 160/90 76 After taking 1 year, the dose is halved, the drug is taken after 3 and a half years, and the blood pressure is stable at 130/80. The practical drug for vascular disease is safe and reliable. It has exact and obvious. The effect is also obvious to the hypertensive patients with arteriosclerosis, and can convert the calcium salts that harm the human body into the calcium needed by the human body. Therefore, the present invention has industrial applicability.

Claims

权利要求 Rights request
1 . 盐酸在制备治疗血管疾病药物中的应用。 1. The use of hydrochloric acid in the preparation of a medicament for treating vascular diseases.
2. 如权利要求 1所述的盐酸在制备治疗血管药物中的应用,所述的药物为 含有盐酸的水溶液, 所述水溶液的 PH值控制在 4 - 7。  The use of hydrochloric acid according to claim 1 for the preparation of a medicament for treating blood vessels, wherein the medicament is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is controlled to 4-7.
3. 如权利要求 1所述的盐酸在制备治疗血管药物中的应用, 其特征在于, 所述的药物为含有盐酸的氷溶液, 所述水溶液的 PH值控制在 6. 5-7。  3. The use of hydrochloric acid according to claim 1 for the preparation of a medicament for treating blood vessels, characterized in that the medicament is an ice solution containing hydrochloric acid, and the pH of the aqueous solution is controlled at 6.5-7.
4. 如权利要求 1所述的盐酸在制备治疗血管药物中的应用, 其特征在于, 所述的药物为含有盐酸的水溶液, 所述水溶液的 PH 值控制在 3. 5 -5. 5。  5。 The pH of the aqueous solution is controlled at 3. 5 -5. 5, the pH of the aqueous solution is controlled to 3. 5 -5.
5. 如权利要求 1所述的盐酸在制备治疗血管药物中的应用, 其特征在于, 所述的药物为含有盐酸的水溶液, 所述水溶液的 PH值为 3. 5。  The use of hydrochloric acid according to claim 1, wherein the drug is an aqueous solution containing hydrochloric acid, and the pH of the aqueous solution is 5.3.
6. 如权利要求 1所述的盐酸在制备治疗血管药物中的应用,所述的药物为 口服液剂型。  6. The use of hydrochloric acid according to claim 1 for the preparation of a medicament for treating blood vessels, said medicament being an oral liquid dosage form.
7. 如权利要求 1所述的盐酸在制备治疗血管药物中的应用, 所述的药物为 注射剂剂型。 7. The use of hydrochloric acid according to claim 1 for the preparation of a medicament for treating blood vessels, said medicament being an injection dosage form.
8. 如权利要求 6或 7所述的盐酸在制备治疗血管药物中的应用, 所述的药 物加入生理盐水或葡萄糖溶液饮料中, 分别控制口服液或注射剂的 PH 值。  The use of hydrochloric acid according to claim 6 or 7 for the preparation of a medicament for treating blood vessels, wherein the medicament is added to a physiological saline or a glucose solution beverage, and the pH of the oral solution or the injection is separately controlled.
9. 如权利要求 6或 7所述的盐酸在制备治疗血管药物中的应用, 所述的药 物采用医用盐酸 +含有大量微量元素的矿泉水 +各种维生素 +氨基酸 +营 养素组成。 The use of hydrochloric acid according to claim 6 or 7 for the preparation of a medicament for treating blood vessels, wherein the medicament comprises medical hydrochloric acid + mineral water containing a large amount of trace elements + various vitamins + amino acids + nutrients.
1 0. 如权利要求 9所述的盐酸在制备治疗血管药物中的应用, 所述的药物 的生产包括如下工艺:  The use of hydrochloric acid according to claim 9 for the preparation of a medicament for treating blood vessels, the production of which comprises the following processes:
原水一机械过滤器一活性碳过滤器一一 5 um精密过滤一一 1 um精密 过滤一一中控纤维超滤系统一一反渗透装置一一緩冲器一一混合发生. 器, 添加铁、 锌、 锰、 电、 钴、 锶、 铬、 硒等微量元素一" "混合发生 器, 添加维生素——混合发生器, 添加氨基酸——混合发生器, 添加 营养素一一器皿发生器, 添加盐酸一一无菌混合器一一緩沖罐一一超 滤系统一一臭氧杀菌一一紫外线杀菌一一进口灌装机罐装一一封口一 一贴商标——包装——紫外线杀菌照射——入库。 Raw water one mechanical filter-activated carbon filter one by one 5 um precision filtration one by one um precision Filtration - a medium-controlled fiber ultrafiltration system - a reverse osmosis device - a buffer - one mixing occurs. The device, adding iron, zinc, manganese, electricity, cobalt, bismuth, chromium, selenium and other trace elements - "mixing occurs , adding vitamins - mixing generator, adding amino acids - mixing generator, adding nutrients - one vessel generator, adding hydrochloric acid - one sterile mixer - one buffer tank - one ultrafiltration system - one ozone sterilization one ultraviolet Sterilization one-by-one imported filling machine canned one mouth one by one label - packaging - ultraviolet sterilization - into the warehouse.
11. 如权利要求 6所述的盐酸制备药物的服用方法, 其特征在于, 所述的 口服液剂型药物在治疗高血压时, 每日应用不少于 1500m l, 分为 3飞 次饮用, 3— 6个月为一个疗程。 The method for administering a preparation of a hydrochloric acid according to claim 6, wherein the oral liquid dosage form is used in the treatment of hypertension, and the application is not less than 1500 ml per day, and is divided into 3 flying times, 3 — 6 months for a course of treatment.
12. 如权利要求 11所述的盐酸制备药物的服用方法, 其特征在于,每日饮 用 2000ml ,分三次饮用,早中餐前一小时各饮 500m l ,晚餐前饮 OOOm l , 一年后一般服药量可减少 1 /4 , 二年后减半, 三年后一般只服维持量 或免服降压药。 12. The method for administering a medicament for preparing hydrochloric acid according to claim 11, wherein the drinking is 2000 ml, three times, and 500 ml each one hour before the morning and middle meal, and the OOOm l before the dinner, and the medicine is taken one year later. The amount can be reduced by 1 / 4, halved after two years, after three years, generally only to maintain the amount or free of antihypertensive drugs.
1 3. 如权利要求 11或 12所述的盐酸制备药物的服用方法, 其特征在于, 所述口服液剂不容许加热饮用。  The method of administering a medicament for preparing hydrochloric acid according to claim 11 or 12, wherein the oral solution is not allowed to be heated and consumed.
14. 如权利要求 7所述的盐酸制备药物的使用方法, 其特征在于, 所述的 注射剂剂型药物在注射用治疗高血压时, 每日的推荐量为 500m l, 分 两次注射, 静脉滴注, 连续 2—3个月为一个疗程。  The method for preparing a medicament for preparing hydrochloric acid according to claim 7, wherein the injectable dosage form has a daily recommended amount of 500 ml in the treatment of hypertension for injection, and is divided into two injections, an intravenous drip. Note, for 2 to 3 months for a course of treatment.
PCT/CN2008/000409 2008-02-02 2008-02-28 Use of hydrochloric acid for the manufacture of medicine in treating vascular disease WO2009100591A1 (en)

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CN101234123A (en) * 2008-02-02 2008-08-06 王德寿 Application of certain concentration hydrochloric acid water for treating blood vessel disease
CN105902565A (en) * 2016-05-11 2016-08-31 吴健忠 Method for reversing sclerosis of artery and other soft tissues
CN106038592A (en) * 2016-06-29 2016-10-26 李仁山 Compound for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof

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