WO2009091904A3 - Microrna based methods and compositions for the treatment of cancer - Google Patents

Microrna based methods and compositions for the treatment of cancer Download PDF

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Publication number
WO2009091904A3
WO2009091904A3 PCT/US2009/031125 US2009031125W WO2009091904A3 WO 2009091904 A3 WO2009091904 A3 WO 2009091904A3 US 2009031125 W US2009031125 W US 2009031125W WO 2009091904 A3 WO2009091904 A3 WO 2009091904A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
mir
compositions
treatment
based methods
Prior art date
Application number
PCT/US2009/031125
Other languages
French (fr)
Other versions
WO2009091904A2 (en
Inventor
Curt I. Civin
Original Assignee
The Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University filed Critical The Johns Hopkins University
Publication of WO2009091904A2 publication Critical patent/WO2009091904A2/en
Publication of WO2009091904A3 publication Critical patent/WO2009091904A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present disclosure relates to the discovery that microRNAs of the invention, in particular miR-10a and miR-27a and functional variants thereof, inhibit cancer cell growth and enhance spontaneous, chemotherapy-induced, and growth factor deprivation-induced apoptosis in hematopoietic cancer cells, but not in normal hematopoietic progenitor/stem cells. Disclosed herein are methods, compositions and kits for the use of microRNAs of the invention, miR-10a and miR- 27a and functional variants thereof, in the treatment of cancer.
PCT/US2009/031125 2008-01-15 2009-01-15 Microrna based methods and compositions for the treatment of cancer WO2009091904A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1119608P 2008-01-15 2008-01-15
US61/011,196 2008-01-15

Publications (2)

Publication Number Publication Date
WO2009091904A2 WO2009091904A2 (en) 2009-07-23
WO2009091904A3 true WO2009091904A3 (en) 2009-10-08

Family

ID=40885883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/031125 WO2009091904A2 (en) 2008-01-15 2009-01-15 Microrna based methods and compositions for the treatment of cancer

Country Status (1)

Country Link
WO (1) WO2009091904A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2460877A1 (en) * 2010-12-01 2012-06-06 Miltenyi Biotec GmbH Modulation of CD133+ hematopoietic stem cells
CN102743765A (en) * 2012-05-24 2012-10-24 上海大学 Application of miR-10a gene in non-small cell lung cancer
CN103966327B (en) * 2014-05-07 2016-02-03 济宁医学院 The application of a kind of miR-27a and diagnostic kit thereof
CA3018221C (en) * 2016-03-31 2023-03-21 Asieris Pharmaceutical Technologies Co., Ltd. Combinational uses of nitroxoline and its analogues with chemotherapies and immunotherapies in the treatment of cancers
CN114366814B (en) * 2022-01-24 2023-05-02 南通大学 Inhibitors of miR-27a-3p and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006048553A1 (en) * 2004-11-03 2006-05-11 Centre National De La Recherche Scientifique - Cnrs Identification and use of mirnas for differentiating myelogenous leukaemia cells
WO2007109236A2 (en) * 2006-03-20 2007-09-27 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006048553A1 (en) * 2004-11-03 2006-05-11 Centre National De La Recherche Scientifique - Cnrs Identification and use of mirnas for differentiating myelogenous leukaemia cells
WO2007109236A2 (en) * 2006-03-20 2007-09-27 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis

Also Published As

Publication number Publication date
WO2009091904A2 (en) 2009-07-23

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