WO2009075768A3 - Optical device and method for real-time chemosensitivity testing - Google Patents

Optical device and method for real-time chemosensitivity testing Download PDF

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Publication number
WO2009075768A3
WO2009075768A3 PCT/US2008/013371 US2008013371W WO2009075768A3 WO 2009075768 A3 WO2009075768 A3 WO 2009075768A3 US 2008013371 W US2008013371 W US 2008013371W WO 2009075768 A3 WO2009075768 A3 WO 2009075768A3
Authority
WO
WIPO (PCT)
Prior art keywords
real
time
tumor
optical device
chemosensitivity testing
Prior art date
Application number
PCT/US2008/013371
Other languages
French (fr)
Other versions
WO2009075768A2 (en
Inventor
Chad Allen Lieber
Mustafa Husen Kabeer
Original Assignee
Children S Hospital Of Orange
Chad Allen Lieber
Mustafa Husen Kabeer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Children S Hospital Of Orange, Chad Allen Lieber, Mustafa Husen Kabeer filed Critical Children S Hospital Of Orange
Publication of WO2009075768A2 publication Critical patent/WO2009075768A2/en
Publication of WO2009075768A3 publication Critical patent/WO2009075768A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons

Abstract

Optical systems and methods for real-time chemosensitivity testing of an in-vivo tumor are described. In one embodiment of the invention, the system comprises a probe (104) that can be inserted near a tumor. Radiation is incident on the tumor and the scattered photons from the tumor are detected by a photonic detector (107). The photonic detector (107) records a Raman spectrum which is compared to one or more Raman spectra in a database.
PCT/US2008/013371 2007-12-07 2008-12-05 Optical device and method for real-time chemosensitivity testing WO2009075768A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1216307P 2007-12-07 2007-12-07
US61/012,163 2007-12-07

Publications (2)

Publication Number Publication Date
WO2009075768A2 WO2009075768A2 (en) 2009-06-18
WO2009075768A3 true WO2009075768A3 (en) 2009-08-20

Family

ID=40756029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013371 WO2009075768A2 (en) 2007-12-07 2008-12-05 Optical device and method for real-time chemosensitivity testing

Country Status (1)

Country Link
WO (1) WO2009075768A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060427A1 (en) * 2017-09-19 2019-03-28 Pendar Technologies, Llc In-vivo monitoring of cellular energetics with raman spectroscopy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039186A1 (en) * 2000-03-10 2002-04-04 Rosenberg Charles W. Von Optical probes and methods for spectral analysis
US20060294604A1 (en) * 2003-02-17 2006-12-28 Fridman Jordan S Model for studying the role of genes in tumor resistance to chemotherapy
US20070264193A1 (en) * 2006-03-29 2007-11-15 Genentech, Inc. Diagnostics and treatments for tumors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039186A1 (en) * 2000-03-10 2002-04-04 Rosenberg Charles W. Von Optical probes and methods for spectral analysis
US20060294604A1 (en) * 2003-02-17 2006-12-28 Fridman Jordan S Model for studying the role of genes in tumor resistance to chemotherapy
US20070264193A1 (en) * 2006-03-29 2007-11-15 Genentech, Inc. Diagnostics and treatments for tumors

Also Published As

Publication number Publication date
WO2009075768A2 (en) 2009-06-18

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