WO2009058690A3 - Nell-1 compositions - Google Patents

Nell-1 compositions Download PDF

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Publication number
WO2009058690A3
WO2009058690A3 PCT/US2008/081168 US2008081168W WO2009058690A3 WO 2009058690 A3 WO2009058690 A3 WO 2009058690A3 US 2008081168 W US2008081168 W US 2008081168W WO 2009058690 A3 WO2009058690 A3 WO 2009058690A3
Authority
WO
WIPO (PCT)
Prior art keywords
nell
compositions
antiangiogenesis
angiogenesis
protein
Prior art date
Application number
PCT/US2008/081168
Other languages
French (fr)
Other versions
WO2009058690A2 (en
Inventor
Kang Ting
Chia Soo
Xinli Zhang
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to CA2704190A priority Critical patent/CA2704190A1/en
Priority to EP08844676A priority patent/EP2214697A4/en
Publication of WO2009058690A2 publication Critical patent/WO2009058690A2/en
Publication of WO2009058690A3 publication Critical patent/WO2009058690A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides an angiogenesis or antiangiogenesis composition including a Nell-1 protein and methods of making and using the same.
PCT/US2008/081168 2007-10-30 2008-10-24 Nell-1 compositions WO2009058690A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2704190A CA2704190A1 (en) 2007-10-30 2008-10-24 Nell-1 compositions
EP08844676A EP2214697A4 (en) 2007-10-30 2008-10-24 Nell-1 compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98390307P 2007-10-30 2007-10-30
US60/983,903 2007-10-30

Publications (2)

Publication Number Publication Date
WO2009058690A2 WO2009058690A2 (en) 2009-05-07
WO2009058690A3 true WO2009058690A3 (en) 2009-09-24

Family

ID=40591716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/081168 WO2009058690A2 (en) 2007-10-30 2008-10-24 Nell-1 compositions

Country Status (3)

Country Link
EP (1) EP2214697A4 (en)
CA (1) CA2704190A1 (en)
WO (1) WO2009058690A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2756168A1 (en) * 2009-03-25 2010-09-30 Kang Ting Isoform nell-1 peptide
WO2019210080A1 (en) * 2018-04-25 2019-10-31 The Regents Of The University Of California Methods and compositions for skeletal and neurological disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060053503A1 (en) * 2004-07-30 2006-03-09 Ut-Battelle, Llc Cranial and vertebral defects associated with loss-of-function of Nell
US20060292670A1 (en) * 2003-02-07 2006-12-28 The Regents Of The University Of California Nell peptide expression systems and bone formation activity of nell peptide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
KR20070121669A (en) * 2005-02-16 2007-12-27 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 Pharmaceutical compositions for treating or preventing bone conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060292670A1 (en) * 2003-02-07 2006-12-28 The Regents Of The University Of California Nell peptide expression systems and bone formation activity of nell peptide
US20060053503A1 (en) * 2004-07-30 2006-03-09 Ut-Battelle, Llc Cranial and vertebral defects associated with loss-of-function of Nell

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KARAGIANNIS, E. D. ET AL.: "Anti-angiogenic peptides identified in thrombospondin type I domains", BIOCHEM. BIOPHY. RES. COM., vol. 359, 2007, pages 63 - 69, XP022103143 *
KURODA, S. ET AL.: "Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2", BIOCHEM. BIOPHY. RES. COM., vol. 265, 1999, pages 79 - 86, XP005100839 *
See also references of EP2214697A4 *
ZHANG, X. ET AL.: "Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development", J. BONE MINER. RES., vol. 18, no. 12, 2003, pages 2126 - 2134, XP009057038 *

Also Published As

Publication number Publication date
EP2214697A4 (en) 2011-05-18
EP2214697A2 (en) 2010-08-11
CA2704190A1 (en) 2009-05-07
WO2009058690A2 (en) 2009-05-07

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