WO2009040274A3 - Automated positioning of a removal tool for removing cell objects - Google Patents

Automated positioning of a removal tool for removing cell objects Download PDF

Info

Publication number
WO2009040274A3
WO2009040274A3 PCT/EP2008/062322 EP2008062322W WO2009040274A3 WO 2009040274 A3 WO2009040274 A3 WO 2009040274A3 EP 2008062322 W EP2008062322 W EP 2008062322W WO 2009040274 A3 WO2009040274 A3 WO 2009040274A3
Authority
WO
WIPO (PCT)
Prior art keywords
removal tool
cell object
automated positioning
removing cell
cell objects
Prior art date
Application number
PCT/EP2008/062322
Other languages
German (de)
French (fr)
Other versions
WO2009040274A2 (en
Inventor
Gerd Bornmann
Hardy Neupert
Marco Meinhardt
Marcel Kretschmann
Original Assignee
Aviso Gmbh Mechatronic Systems
Gerd Bornmann
Hardy Neupert
Marco Meinhardt
Marcel Kretschmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aviso Gmbh Mechatronic Systems, Gerd Bornmann, Hardy Neupert, Marco Meinhardt, Marcel Kretschmann filed Critical Aviso Gmbh Mechatronic Systems
Publication of WO2009040274A2 publication Critical patent/WO2009040274A2/en
Publication of WO2009040274A3 publication Critical patent/WO2009040274A3/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/32—Micromanipulators structurally combined with microscopes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/288—Filter punches
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microscoopes, Condenser (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Machine Tool Sensing Apparatuses (AREA)

Abstract

The invention relates to a method for automated positioning of a removal tool for removing cell objects, wherein the removal tool is mounted in a mounting element on a toolholder, the spatial position of the cell object in a sample container being detected by means of an imaging unit and an image interpretation unit, and the removal tool being moved by means of a control and memory unit and a moving mechanism, first into a calibration position, then into a position above the cell object. In order to allow more precise positioning of the removal tool relative to the cell object to be removed, the imaging unit and the image interpretation unit subsequently detect the spatial position of the removal tool above the cell object and determine a deviation from the required position. The control and memory unit then corrects the position of the removal tool by means of the moving mechanism.
PCT/EP2008/062322 2007-09-20 2008-09-16 Automated positioning of a removal tool for removing cell objects WO2009040274A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007046267.2 2007-09-20
DE200710046267 DE102007046267A1 (en) 2007-09-20 2007-09-20 Automatic positioning of a removal tool for removal of cell objects

Publications (2)

Publication Number Publication Date
WO2009040274A2 WO2009040274A2 (en) 2009-04-02
WO2009040274A3 true WO2009040274A3 (en) 2009-08-06

Family

ID=40343699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/062322 WO2009040274A2 (en) 2007-09-20 2008-09-16 Automated positioning of a removal tool for removing cell objects

Country Status (2)

Country Link
DE (1) DE102007046267A1 (en)
WO (1) WO2009040274A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112146954B (en) * 2020-09-22 2021-05-11 广州海研生物科技有限公司 Biological sealing piece equipment

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2378341A1 (en) 2010-04-15 2011-10-19 Mmi Ag Method for collision-free positioning of a micromanipulation tool
CN102918376B (en) * 2010-05-28 2015-07-15 奥林巴斯株式会社 Cell sorter, cell sorting system, and cell sorting method
DE102010035104A1 (en) * 2010-08-23 2012-04-05 Euroimmun Medizinische Labordiagnostika Ag Automatic focusing apparatus and method for low luminance microscopy microscopy
DE102012104708B3 (en) * 2012-05-31 2013-07-18 Dionex Softron Gmbh Method for handling liquid kept in vessel for sample receiver, involves controlling oscillation of sample receiver and monitoring oscillated sample receiver for change in frequency or amplitude to detect immersion in liquid
DE102013216938B3 (en) 2013-08-26 2015-01-08 Leica Microsystems Cms Gmbh Method for calibrating a laser deflector of a laser microdissection system and laser microdissection system
CN106995779B (en) * 2017-05-03 2023-06-02 浙江天科高新技术发展有限公司 Microorganism sampler for inner wall and crack surface of pipeline and sampling method thereof
DE102017117789A1 (en) * 2017-08-04 2019-02-07 Als Automated Lab Solutions Gmbh Adapter for receiving a capillary and its use
DE102022102711A1 (en) 2022-02-04 2023-08-10 Lpkf Laser & Electronics Aktiengesellschaft Device and a method intended to be carried out for examining and/or treating a particularly biological or medical sample

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10136572A1 (en) * 2001-07-27 2003-02-13 Eppendorf Ag Micro-manipulation of biological cell or tissue specimens for microscope, comprising coupling between drive motors for micro-manipulators, and microscope focusing system, operated from a common control panel
DE10253939A1 (en) * 2002-11-19 2004-06-17 Cetoni Gmbh Innovative Informationssysteme Process for the exact three-dimensional micropositioning of bodies of different geometry and / or dimensions in space
US20040257561A1 (en) * 2000-11-24 2004-12-23 Takao Nakagawa Apparatus and method for sampling
DE102005053669A1 (en) * 2005-11-08 2007-05-16 Roland Kilper Sample manipulation device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004046740B4 (en) 2004-06-07 2006-07-06 Aviso Gmbh Mechatronic Systems Tool head for a device for the automatic isolation and treatment of cell clones

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040257561A1 (en) * 2000-11-24 2004-12-23 Takao Nakagawa Apparatus and method for sampling
DE10136572A1 (en) * 2001-07-27 2003-02-13 Eppendorf Ag Micro-manipulation of biological cell or tissue specimens for microscope, comprising coupling between drive motors for micro-manipulators, and microscope focusing system, operated from a common control panel
DE10253939A1 (en) * 2002-11-19 2004-06-17 Cetoni Gmbh Innovative Informationssysteme Process for the exact three-dimensional micropositioning of bodies of different geometry and / or dimensions in space
DE102005053669A1 (en) * 2005-11-08 2007-05-16 Roland Kilper Sample manipulation device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112146954B (en) * 2020-09-22 2021-05-11 广州海研生物科技有限公司 Biological sealing piece equipment

Also Published As

Publication number Publication date
WO2009040274A2 (en) 2009-04-02
DE102007046267A1 (en) 2009-04-02

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