WO2008112297A3 - Methods of treating cancer by interfering with igf-i receptor signaling - Google Patents
Methods of treating cancer by interfering with igf-i receptor signaling Download PDFInfo
- Publication number
- WO2008112297A3 WO2008112297A3 PCT/US2008/003393 US2008003393W WO2008112297A3 WO 2008112297 A3 WO2008112297 A3 WO 2008112297A3 US 2008003393 W US2008003393 W US 2008003393W WO 2008112297 A3 WO2008112297 A3 WO 2008112297A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- igf
- treating cancer
- interfering
- methods
- receptor signaling
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000011664 signaling Effects 0.000 title abstract 2
- 102000038455 IGF Type 1 Receptor Human genes 0.000 title 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 title 1
- 230000002452 interceptive effect Effects 0.000 title 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 abstract 1
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 abstract 1
- QTDMGAWIBXJNRR-UHFFFAOYSA-N Mangostin Natural products CC(=CCc1c(O)cc2Oc3cc(C)c(O)c(CC=C(C)C)c3C(=O)c2c1O)C QTDMGAWIBXJNRR-UHFFFAOYSA-N 0.000 abstract 1
- 108020004459 Small interfering RNA Proteins 0.000 abstract 1
- GNRIZKKCNOBBMO-UHFFFAOYSA-N alpha-mangostin Chemical compound OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3OC2=C1 GNRIZKKCNOBBMO-UHFFFAOYSA-N 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- 150000001783 ceramides Chemical class 0.000 abstract 1
- 229960004606 clomipramine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003914 desipramine Drugs 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- -1 siRNA Chemical class 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention includes methods of reducing proliferation, causing apoptosis and treating cancer through the inhibition of ASM, the disruption of lipid rafts and the interference with IGF-IR and Racl signaling using a variety of compounds including siRNA, anti-ASM antibodies, anti-ceramide antibodies, short- chain ceramide derivatives, desipramine, clomipramine, mangostin and/or sphingomyelin substrate analogues.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90667307P | 2007-03-13 | 2007-03-13 | |
US60/906,673 | 2007-03-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008112297A2 WO2008112297A2 (en) | 2008-09-18 |
WO2008112297A3 true WO2008112297A3 (en) | 2008-10-30 |
Family
ID=39760296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/003393 WO2008112297A2 (en) | 2007-03-13 | 2008-03-13 | Methods of treating cancer by interfering with igf-i receptor signaling |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008112297A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2363394B2 (en) * | 2010-01-19 | 2012-01-31 | Universidad De Sevilla | USE OF AMITRIPTILINE AS AN ANTITUMORAL AGENT FOR THE TREATMENT OF LUNG CANCER. |
WO2012036180A1 (en) * | 2010-09-16 | 2012-03-22 | 株式会社エコリソース研究所 | Xanthone derivative and use thereof |
CL2011000273A1 (en) | 2011-02-08 | 2011-06-17 | Univ Pontificia Catolica Chile | Use of a phosphatidic acid phosphohydrolase enzyme (pap) inhibitor or combination of inhibitors, in which the inhibitor is d (+) propranolol, and the combination is racemic mixture of propranolol od (+) propranolol together with desipramine, to prepare a Useful medicine in the treatment of cancer. |
CN105218507B (en) * | 2015-09-30 | 2020-10-02 | 中国药科大学 | 1, 3, 6, 7-tetrahydroxy xanthone derivative and preparation method and application thereof |
EP4349866A1 (en) * | 2021-05-27 | 2024-04-10 | Isu Abxis Co., Ltd. | Antibody specifically binding to asm protein |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030228276A1 (en) * | 2002-04-09 | 2003-12-11 | Pitossi Fernando Juan | Neuroprotective and neurogenerative effects of the long-term expression of TNF alpha in the substantia nigra and a new animal model for Parkinson's disease |
US20040247603A1 (en) * | 2000-12-22 | 2004-12-09 | Medlyte, Inc. | Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation |
US20040259816A1 (en) * | 2002-10-01 | 2004-12-23 | Pandol Stephen J. | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
US20050002865A1 (en) * | 1996-10-28 | 2005-01-06 | Amersham Health As | Diagnostic/therapeutic agents |
US20050209219A1 (en) * | 2002-08-23 | 2005-09-22 | Erich Gulbins | Prophylaxis and treatment of infectious diseases |
US20060003968A1 (en) * | 2004-04-02 | 2006-01-05 | Jeremy Green | Azaindoles useful as inhibitors of rock and other protein kinases |
-
2008
- 2008-03-13 WO PCT/US2008/003393 patent/WO2008112297A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050002865A1 (en) * | 1996-10-28 | 2005-01-06 | Amersham Health As | Diagnostic/therapeutic agents |
US20040247603A1 (en) * | 2000-12-22 | 2004-12-09 | Medlyte, Inc. | Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation |
US20030228276A1 (en) * | 2002-04-09 | 2003-12-11 | Pitossi Fernando Juan | Neuroprotective and neurogenerative effects of the long-term expression of TNF alpha in the substantia nigra and a new animal model for Parkinson's disease |
US20050209219A1 (en) * | 2002-08-23 | 2005-09-22 | Erich Gulbins | Prophylaxis and treatment of infectious diseases |
US20040259816A1 (en) * | 2002-10-01 | 2004-12-23 | Pandol Stephen J. | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
US20060003968A1 (en) * | 2004-04-02 | 2006-01-05 | Jeremy Green | Azaindoles useful as inhibitors of rock and other protein kinases |
Non-Patent Citations (2)
Title |
---|
HAMADA ET AL.: "Biological Activities of a-Mangostin Derivatives against Acidic Sphingomyelinase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pages 3151 - 3153, XP002728402, DOI: doi:10.1016/S0960-894X(03)00719-4 * |
OKAMOTO ET AL.: "Inhibitory Regulation of Rac Activation, Membrane Ruffting, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but not EDG1 Or EDG3", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 24, 2000, pages 9247 - 9261, XP002951031 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008112297A2 (en) | 2008-09-18 |
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