WO2008052088A8 - Chromane derivatives, synthesis thereof, and intermediates thereto - Google Patents
Chromane derivatives, synthesis thereof, and intermediates theretoInfo
- Publication number
- WO2008052088A8 WO2008052088A8 PCT/US2007/082452 US2007082452W WO2008052088A8 WO 2008052088 A8 WO2008052088 A8 WO 2008052088A8 US 2007082452 W US2007082452 W US 2007082452W WO 2008052088 A8 WO2008052088 A8 WO 2008052088A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- intermediates
- synthesis
- compounds
- chromane derivatives
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Abstract
Methods of preparing compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85438206P | 2006-10-25 | 2006-10-25 | |
US60/854,382 | 2006-10-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008052088A1 WO2008052088A1 (en) | 2008-05-02 |
WO2008052088A8 true WO2008052088A8 (en) | 2008-09-25 |
Family
ID=39029809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/082452 WO2008052088A1 (en) | 2006-10-25 | 2007-10-24 | Chromane derivatives, synthesis thereof, and intermediates thereto |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR063372A1 (en) |
CL (1) | CL2007003066A1 (en) |
PE (1) | PE20081139A1 (en) |
TW (1) | TW200831478A (en) |
WO (1) | WO2008052088A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2216023A4 (en) | 2007-11-15 | 2013-03-13 | Takeda Pharmaceutical | Condensed pyridine derivative and use thereof |
US20120253036A1 (en) | 2009-12-11 | 2012-10-04 | Yukinori Nagakura | Agent for treating fibromyalgia |
CN102329199B (en) * | 2011-07-19 | 2014-04-02 | 黑龙江大学 | Method for synthesizing biphenyl compounds under composite catalytic actions of Pd/C and crown ether |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
CN103553859B (en) * | 2013-11-14 | 2015-09-16 | 竺叶洪 | A kind of method being prepared aminated compounds intermediate by acid amides |
CN104591939B (en) * | 2015-01-31 | 2016-06-15 | 台州学院 | A kind of method preparing xenyl acrylic acid ether compound |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4135474A1 (en) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-AMINOMETHYL-chromans |
BR0213094A (en) * | 2001-10-04 | 2004-10-13 | Wyeth Corp | Chroman derivatives as 5-hydroxy tryptamine-6 ligands |
WO2003029239A1 (en) * | 2001-10-04 | 2003-04-10 | Wyeth | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands |
WO2003031439A1 (en) * | 2001-10-05 | 2003-04-17 | Wyeth | Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
CA2605587A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Chromane and chromene derivatives and uses thereof |
-
2007
- 2007-10-24 WO PCT/US2007/082452 patent/WO2008052088A1/en active Application Filing
- 2007-10-24 AR ARP070104704A patent/AR063372A1/en unknown
- 2007-10-24 CL CL2007003066A patent/CL2007003066A1/en unknown
- 2007-10-24 PE PE2007001449A patent/PE20081139A1/en not_active Application Discontinuation
- 2007-10-24 TW TW096139839A patent/TW200831478A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR063372A1 (en) | 2009-01-21 |
PE20081139A1 (en) | 2008-09-18 |
CL2007003066A1 (en) | 2008-01-25 |
WO2008052088A1 (en) | 2008-05-02 |
TW200831478A (en) | 2008-08-01 |
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